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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Review Future prospects and development strategies of insect industry for food and feed in Korea In the last two decades, there was a sharp increase of utilizing insects as a biological resource. In Korea especially, the insect industrialization developed rapidly in relation to the governmental legislation on the utilization of insect resources. This review provides the future prospects and development strategies of the insect industry for food and feed in Korea. Kwon, Ohseok Kyungpook Natl Univ, Sch Appl Biosci, Coll Agr & Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Plant Protect & Quarantine, Daegu, South Korea 56323648400 ecoento@knu.ac.kr; ENTOMOLOGICAL RESEARCH ENTOMOL RES 1738-2297 1748-5967 52 8 SCIE ENTOMOLOGY 2022 1.3 50.5 0.17 2025-06-25 2 3 biological resource; edible insect; food insect; insect feed; insect industrialization biological resource; edible insect; food insect; insect feed; insect industrialization English 2022 2022-08 10.1111/1748-5967.12611 바로가기 바로가기 바로가기 바로가기
Article Genetic variation of chigger mites in the Republic of Korea The chigger mite is a known vector for the zoonotic disease, Tsutsugamushi, which affects more than 4,000 patients each year in the Republic of Korea (ROK) since 2004. However, molecular data is only available for a few species of chigger mite, compared to the numbers of known species. This study focused on securing molecular data for six species (Leptotrombidium pallidum, Leptotrombidium scutellare, Leptotrombidium palpale, Leptotrombidium orientale, Neotrombicula gardellai, and Eushoengastia koreaensis) of chigger mites in the ROK from cytochrome c oxidase subunit I (COI) and internal transcribed spacer 2 (ITS2). In the results, there were each two genotypes in L. pallidum and L. palpale, and three genotypes in L. scutellae in the COI, whereas the ITS2 sequence was identical within the species. The other three species were identical from COI and ITS2. This study first revealed the genetic variation in the COI sequences of chigger mites in the ROK. Further studies could determine how this variation is related to ecological behavior and disease transmission. Lee, Hyeon Seung; Choi, Kwang Shik Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pnylogen & Evolut, Daegu, South Korea Lee, Seunghwan/E-4992-2011 57225171629; 36602283400 ksc@knu.ac.kr; ENTOMOLOGICAL RESEARCH ENTOMOL RES 1738-2297 1748-5967 52 9 SCIE ENTOMOLOGY 2022 1.3 50.5 0.39 2025-06-25 3 2 Chigger mite; COI; Genetic variation; ITS2 COI AMPLIFICATION; SCRUB TYPHUS; ITS2; PRIMERS; DIVERSITY; SET Chigger mite; COI; Genetic variation; ITS2 English 2022 2022-09 10.1111/1748-5967.12612 바로가기 바로가기 바로가기 바로가기
Article Hadronotus pubescens (Motschoulsky) (Hymenoptera, Scelionidae): Redescription, biological attributes, and parasitism on eggs of Riptortus pedestris (Fab.) (Hemiptera, Alydidae) Riptortus pedestris (Fab.) (Hemiptera, Alydidae) is one of the most damaging insects of leguminous crops in Eastern Asia but has only recently emerged as a pest in Bangladesh. Eggs, nymphs and adults of R. pedestris are here reported from mung bean (Vigna radiata (L.)) fields in Bangladesh. Two parasitoid species were reared from field-collected eggs of R. pedestris, the solitary Hadronotus pubescens (Motschoulsky) (Hyme-noptera, Scelionidae) and a gregarious species of Ooencyrtus Ashmead (Hymenoptera, Encyrtidae). Here we redescribe H. pubescens, treat H. hogenakalensis (Sharma) as a junior synonym, and report aspects of its biology that were investigated under laboratory conditions. lhe number of eggs parasitized by H. pubescens was constant with eggs up to 48 hours in age, decreasing by 14% for 96 hour-old eggs. As host egg age increased, the parasitoid mean development time increased and the longevity of the parasitoids decreased. Raju, Rasel; Arifunnahar; Mostafiz, Munir; Alim, Abdul; Hossain, Alamgir; Talamas, Elijah J. Hajee Mohammad Danesh Sci & Technol Univ, Dept Entomol, Dinajpur 5200, Bangladesh; Kyungpook Natl Univ, Coll Agr & Life Sci, Div Appl Biosci, Daegu Gwangyeogsi 41566, South Korea; Florida State Dept Agr, Consumer Serv, Div Plant Ind, Gainesville, FL 32608 USA Hossain, Md. Alamgir/A-5284-2018; Mostafiz, Md. Munir/AAD-7664-2019 58066696500; 57188716838; 57204895546; 59578238000; 59603809400; 42262998100 alim@hstu.ac.bd;elijah.talamas@fdacs.gov; JOURNAL OF HYMENOPTERA RESEARCH J HYMENOPT RES 1070-9428 1314-2607 94 SCIE ENTOMOLOGY 2022 1.3 50.5 0.35 2025-06-25 2 2 bean bug; biological control; egg parasitoid; mass rearing; mung bean CLAVATUS THUNBERG HETEROPTERA; OOENCYRTUS-NEZARAE ISHII; SEASONAL OCCURRENCE; PHYTOPHAGOUS BUGS; CONTROL AGENTS; BEAN BUG; BEHAVIOR; PLATYGASTROIDEA; PHEROMONE; SOYBEANS bean bug; biological control; egg parasitoid; mass rearing; mung bean English 2022 2022-12-20 10.3897/jhr.94.93512 바로가기 바로가기 바로가기 바로가기
Article Improvement of IgA Nephropathy and Kidney Regeneration by Functionalized Hyaluronic Acid and Gelatin Hydrogel Background: Immunoglobulin A (IgA) nephropathy (IgAN) is one of an important cause of progressive kidney disease and occurs when IgA settles in the kidney resulted in disrupts kidney's ability to filter waste and excess water. Hydrogels are promising material for medical applications owing to their excellent adaptability and filling ability. Herein, we proposed a hyaluronic acid/gelatin (CHO-HA/Gel-NH2) bioactive hydrogel as a cell carrier for therapeutic kidney regeneration in IgAN. Methods: CHO-HA/Gel-NH2 hydrogel was fabricated by Schiff-base reaction without any additional crosslinking agents. The hydrogel concentrations and ratios were evaluated to enhance adequate mechanical properties and biocompatibility for further in vivo study. High serum IgA ddY mice kidneys were treated with human urine-derived renal progenitor cells encapsulated in the hydrogel to investigate the improvement of IgA nephropathy and kidney regeneration. Results: The stiffness of the hydrogel was significantly enhanced and could be modulated by altering the concentrations and ratios of hydrogel. CHO-HA/Gel-NH2 at a ratio of 3/7 provided a promising milieu for cells viability and cells proliferation. From week four onwards, there was a significant reduction in blood urea nitrogen and serum creatinine level in Cell/Gel group, as well as well-organized glomeruli and tubules. Moreover, the expression of pro-inflammatory and pro-fibrotic molecules significantly decreased in the Gel/Cell group, whereas anti-inflammatory gene expression was elevated compared to the Cell group. Conclusion: Based on in vivo studies, the renal regenerative ability of the progenitor cells could be further increased by this hydrogel system. Khunmanee, Sureerat; Chun, So Young; Ha, Yun-Sok; Lee, Jun Nyung; Kim, Bum Soo; Gao, Wei-Wei; Kim, In Yong; Han, Dong Keun; You, Seungkwon; Kwon, Tae Gyun; Park, Hansoo Chung Ang Univ, Dept Integrat Engn, 221 Heukseok Dong, Seoul 06974, South Korea; Kyungpook Natl Univ Hosp, BioMed Res Inst, Daegu 41940, South Korea; Kyungpook Natl Univ Hosp, Dept Urol, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Urol, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41566, South Korea; Korea Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 02841, South Korea; CHA Univ, Coll Life Sci, Dept Biomed Sci, 335 Pangyo Ro, Seongnam Si 13488, Gyeonggi, South Korea Kim, Soo-Yeon/ADR-9663-2022; Kim, In Yong/GWD-0161-2022 56991092800; 8688166900; 35487226400; 16301364600; 57202817150; 57371096300; 57193935011; 7403219478; 7201516933; 15073765400; 55799330700 tgkwon@knu.ac.kr;heyshoo@cau.ac.kr; TISSUE ENGINEERING AND REGENERATIVE MEDICINE TISSUE ENG REGEN MED 1738-2696 2212-5469 19 3 SCIE CELL & TISSUE ENGINEERING;ENGINEERING, BIOMEDICAL 2022 3.6 50.5 0.65 2025-06-25 5 6 Injectable hydrogel; Urine-derived renal progenitor cells; IgA nephropathy RENAL PROGENITOR CELLS; STEM-CELLS; INJECTABLE HYDROGEL; CHITOSAN; DESIGN IgA nephropathy; Injectable hydrogel; Urine-derived renal progenitor cells Animals; Gelatin; Glomerulonephritis, IGA; Hyaluronic Acid; Hydrogels; Immunoglobulin A; Kidney; Mice; Regeneration; Biocompatibility; Biomechanics; Crosslinking; Cytology; Gene expression; Hyaluronic acid; Mammals; Medical applications; Organic acids; Tissue; Urea; creatinine; gelatin; hyaluronic acid; hydrogel; Schiff base; gelatin; hyaluronic acid; immunoglobulin A; Functionalized; Gelatin hydrogels; Hyaluronic acid hydrogels; Immunoglobulin A nephropathy; In-vivo; Injectable hydrogels; Nephropathy; Progenitor cell; Urine-derived renal progenitor cell; Vivo studies; animal tissue; Article; cell culture; cell proliferation; cell viability; concentration (parameter); controlled study; creatinine blood level; cross linking; embryo; female; Fourier transform infrared spectroscopy; gene expression; histopathology; human; human cell; immunoglobulin A nephropathy; immunohistochemistry; in vivo study; kidney function; kidney regeneration; mouse; nanoencapsulation; nanofabrication; nonhuman; real time polymerase chain reaction; stem cell; stem cell transplantation; tissue regeneration; urea nitrogen blood level; urine derived renal progenitor cell; urine derived renal progenitor cell transplantation; animal; hydrogel; immunoglobulin A nephropathy; kidney; regeneration; Hydrogels English 2022 2022-06 10.1007/s13770-022-00442-8 바로가기 바로가기 바로가기 바로가기
Article Pollen metabarcoding reveals the floral resources and niche overlap of honeybees in forest areas We investigated the floral resources of the honeybee (Apis mellifera) by pollen DNA metabarcoding as the first step in honeybee conservation. We attempted to identify as many floral resources and as wide resource availability as possible in areas and compared the richness of floral resources between forests and national parks. We found that both forest and national parks can sufficiently support honeybee floral resources; however, national parks were more stable habitats with more complex vegetation structure than those of forests. Also, honeybee's preferences for floral resources were determined using niche breadth, niche overlap, and network analysis among the floral resources in forest areas. Quercus and Actinidia were the most frequently detected taxa of pollen resources in both forests and national parks by pollen metabarcoding. Even though we anticipated that more various pollen resource taxa would be found in national parks than forests, no differences in the number pollen resource taxa were detected between them. According to the niche overlap analysis result, the honeybee preferred the pollen resources in both forests and national parks, and the co-occurrence pattern analysis of pollen resource taxa in both forests and national parks showed a simple network. Altogether, our findings suggested that DNA metabarcoding of pollen collected by the honeybee can provide useful information on the flowering plants in a given area. As the use of floral pollen resources varies spatially and temporally, periodic monitoring of pollen resources can identify which pollen is required to maintain the health of honeybee colonies. Do, Yuno; Park, Woong-Bae; Park, Jun-Kyu; Kim, Chang-Jun; Kim, Il-Kwon; Choi, Moon Bo Kongju Natl Univ, Dept Biol Sci, Gongju, South Korea; Korea Natl Arboretum, Res Panning & Coordinat Team, Gyeonggi, Pocheon, South Korea; Korea Natl Arboretum, Div Forest Biodivers, Pochon, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea KIm, Changjun/GZM-7308-2022; Park, Junkyu/AAE-1509-2020 52163435800; 57537588500; 57216365592; 55286588300; 55477687300; 51863232400 ilkwons91@korea.kr;kosinchoi@hanmail.net; ENTOMOLOGICAL RESEARCH ENTOMOL RES 1738-2297 1748-5967 52 12 SCIE ENTOMOLOGY 2022 1.3 50.5 0 2025-06-25 1 1 A; mellifera; DNA metabarcoding; niche; pollen BEE POLLEN; HABITAT; LANDSCAPE; TRENDS A. mellifera; DNA metabarcoding; niche; pollen English 2022 2022-12 10.1111/1748-5967.12625 바로가기 바로가기 바로가기 바로가기
Article Restoration of Immune Privilege in Human Dermal Papillae Controlling Epithelial-Mesenchymal Interactions in Hair Formation BACKGROUND: Hair follicles are among a handful of organs that exhibit immune privilege. Dysfunction of the hair follicle immune system underlies the development of inflammatory diseases, such as alopecia areata. METHODS: Quantitative reverse transcription PCR and immunostaining was used to confirm the expression of major histocompatibility complex class I in human dermal papilla cells. Through transcriptomic analyses of human keratinocyte stem cells, major histocompatibility complex class I was identified as differentially expressed genes. Organ culture and patch assay were performed to assess the ability of WNT3a conditioned media to rescue immune privilege. Lastly, CD8+ T cells were detected near the hair bulb in alopecia areata patients through immunohistochemistry. RESULTS: Inflammatory factors such as tumor necrosis factor alpha and interferon gamma were verified to induce the expression of major histocompatibility complex class I proteins in dermal papilla cells. Additionally, loss of immune privilege of hair follicles was rescued following treatment with conditioned media from outer root sheath cells. Transcriptomic analyses found 58 up-regulated genes and 183 down-regulated genes related in MHC class I+ cells. Using newborn hair patch assay, we demonstrated that WNT3a conditioned media with epidermal growth factor can restore hair growth. In alopecia areata patients, CD8+ T cells were increased during the transition from mid-anagen to late catagen. CONCLUSION: Identification of mechanisms governing epithelial and mesenchymal interactions of the hair follicle facilitates an improved understanding of the regulation of hair follicle immune privilege. Park, Jung Min; Jun, Mee Sook; Kim, Jung-A.; Mali, Nanda Maya; Hsi, Tsai-Ching; Cho, Areum; Kim, Jung Chul; Kim, Jun Young; Seo, Incheol; Kim, Jungmin; Kim, Moonkyu; Oh, Ji Won Kyungpook Natl Univ, Dept Anat, Sch Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Dept Microbiol, Sch Med, Daegu, South Korea; Immune Sq Inc, Daegu, South Korea; Kyungpook Natl Univ, Dept Immunol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Hair Transplantat Ctr, Daegu, South Korea; Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea; Dongguk Univ, Dept Microbiol, Coll Med, Gyeongju, South Korea ; Kim, Jung-Ae/B-1389-2013; Oh, Ji/AAZ-3153-2020 57195987554; 7006544857; 57289436200; 57195987350; 55912960800; 57289612400; 57207436677; 35310922800; 56022683900; 57211297681; 57199748390; 36093206200 moonkim@knu.ac.kr;ohjiwon@knu.ac.kr; TISSUE ENGINEERING AND REGENERATIVE MEDICINE TISSUE ENG REGEN MED 1738-2696 2212-5469 19 1 SCIE CELL & TISSUE ENGINEERING;ENGINEERING, BIOMEDICAL 2022 3.6 50.5 0.65 2025-06-25 6 6 Immune privilege; Hair follicle; MHC molecule; Epithelial-mesenchymal interaction EPIDERMAL-GROWTH-FACTOR; CLASS-I EXPRESSION; STEM-CELLS; FOLLICLE; LYMPHOCYTES; CYTOKINES; RECEPTOR; TARGET; GENES; VITRO Epithelial-mesenchymal interaction; Hair follicle; Immune privilege; MHC molecule Alopecia Areata; Epidermal Growth Factor; Hair Follicle; Histocompatibility Antigens Class I; Humans; Immune Privilege; Infant, Newborn; Cell death; Glycoproteins; Restoration; Stem cells; Transcription; cytokine; epidermal growth factor; gamma interferon; major histocompatibility antigen class 1; tumor necrosis factor; Wnt3a protein; epidermal growth factor; HLA antigen class 1; Class I; Conditioned medium; Dermal papilla; Epithelial-mesenchymal interaction; Hair follicles; Immune privilege; Major histocompatibility complex class; MHC molecule; Papilla cells; Transcriptomics; alopecia areata; Article; bioassay; CD8+ T lymphocyte; cellular distribution; controlled study; dermal papilla cell; differential gene expression; down regulation; epithelial mesenchymal transition; gene identification; hair follicle; hair growth; hair patch assay; hair root; human; human cell; human tissue; immune privilege; immune response; immune response gene; immune restoration; immune system; immunohistochemistry; in vitro study; keratinocyte; keratinocyte stem cell; major histocompatibility complex class I gene; organ culture; protein expression; reverse transcription polymerase chain reaction; skin cell; stem cell; transcriptomics; upregulation; alopecia areata; genetics; metabolism; newborn; T-cells English 2022 2022-02 10.1007/s13770-021-00392-7 바로가기 바로가기 바로가기 바로가기
Article Selective Serotonin Reuptake Inhibitor Promotes Bone-Tendon Interface Healing in a Rotator Cuff Tear Rat Model Background: Selective serotonin reuptake inhibitor (SSRI) is believed to accelerate wound healing, and thus expected to have a positive effect on rotator cuff repair. We hypothesized that SSRI has a positive effect on the healing of the bone-tendon interface (BTI), and improved rotator cuff tear healing would be confirmed by mechanical strength measurements and histological assessment of the restored tendon. Methods: The study used 40 adult male Sprague-Dawley wild-type rats. The animals were divided into two groups: group-SSRI, the supraspinatus repair with SSRI injection group, and group-C, conventional supraspinatus repair only without SSRI. Biomechanical and histological analyses were performed 8 weeks after index rotator cuff surgery. Results: The ultimate load (N) was significantly higher in group-SSRI than in group-C (54.8 +/- 56.9 Vs 25.1 +/- 11.1, p = .031). In the histological evaluation, the Bonar score confirmed significant differences in collagen fiber density (group-C: 0.6 +/- 0.5, group-SSRI: 1.1 +/- 0.6, p = .024), vascularity (group-C: 0.1 +/- 0.2, group-SSRI: 0.3 +/- 0.4, p = .024) and cellularity (group-C: 1.7 +/- 0.4, group-SSRI: 2.0 +/- 0.0, p = .023) between the groups. Based on the total score, group-SSRI was significantly better compared with group-C (6.3 +/- 2.7 Vs 4.3 +/- 1.9, p = .019). Conclusion: Our study demonstrated that SSRI could facilitate improved biomechanical and histological outcomes 8 weeks after rotator cuff repair in a rat model. Consequently, SSRI may improve healing after rotator cuff repair. Yoon, Jong Pil; Yoon, Jee Wook; Kim, Hun-Min; Oh, Joo Han Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, Daegu 41944, South Korea; Korea Dyeing & Finishing Technol Inst, Funct Mat R&D Grp, Daegu 41706, South Korea; Seoul Natl Univ, Sch Med, Dept Orthoped Surg, 101 Daehak Ro, Seoul 03080, South Korea Kim, Sae/AAR-3907-2020 36098548400; 57188967905; 57210831160; 7402155166 ohjh1@snu.ac.kr; TISSUE ENGINEERING AND REGENERATIVE MEDICINE TISSUE ENG REGEN MED 1738-2696 2212-5469 19 4 SCIE CELL & TISSUE ENGINEERING;ENGINEERING, BIOMEDICAL 2022 3.6 50.5 0.86 2025-06-25 8 8 Serotonin uptake inhibitors; Anti-inflammatory agents; Histology; Biomechanics; Rotator cuff healing FLUOXETINE; STRESS; REPAIR; ACTIVATION; CYTOKINES; GROWTH Anti-inflammatory agents; Biomechanics; Histology; Rotator cuff healing; Serotonin uptake inhibitors Animals; Biomechanical Phenomena; Male; Rats; Rats, Sprague-Dawley; Rotator Cuff Injuries; Serotonin Uptake Inhibitors; Tendons; Wound Healing; Biomechanics; Rats; Repair; sertraline; serotonin uptake inhibitor; Anti-inflammatory agents; Group-selective; Interface healing; Rat model; Rotator cuff; Rotator cuff healing; Rotator cuff repairs; Selective serotonin re-uptake inhibitors; Serotonin uptake inhibitor; Wound healing; adult; animal experiment; animal model; Article; biomechanics; bone maturation; collagen fiber; controlled study; drug determination; drug effect; healing; male; nonhuman; rat; rotator cuff repair; rotator cuff rupture; supraspinatus muscle; tendon; vascularization; animal; biomechanics; pathology; rotator cuff injury; Sprague Dawley rat; tendon; wound healing; Tendons English 2022 2022-08 10.1007/s13770-022-00444-6 바로가기 바로가기 바로가기 바로가기
Article Species diversity of the Culex pipiens complex in the Republic of Korea The Culex pipiens complex, a common species in urban areas, has not yet caused a disease in the Republic of Korea, although it is abundant across residential areas. This complex is a major vector of West Nile virus in the United States. Additionally, Culex pipiens molestus and Culex pipiens pallens in the Republic of Korea are known to have vector competence. However, it is difficult to morphologically distinguish Culex pipiens complex species in the Republic of Korea. In this study, samples were collected from 48 sites near residential areas in the Republic of Korea, and the distribution of Culex pipiens complex species was firstly analyzed using species-specific primers. Culex p. molestus and Cx. p. pallens were collected in large numbers in all the study regions except Ulleungdo, where the number of samples collected was five. Of the total 1063 samples, 70.1% were Cx. p. molestus and 29.9% were Cx. p. pallens. As there has been no research on the diversity of these species in the Republic of Korea, the results of this study would provide important baseline data for further studies on the Culex pipiens complex. Ryu, Jihun; Choi, Kwang Shik Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, Daegu, South Korea; Kyungpook Natl Univ, Inst Phylogen & Evolut, Daegu, South Korea Ryu, Jihun/MSY-6008-2025 57210884178; 36602283400 ksc@knu.ac.kr; ENTOMOLOGICAL RESEARCH ENTOMOL RES 1738-2297 1748-5967 52 8 SCIE ENTOMOLOGY 2022 1.3 50.5 1.55 2025-06-25 8 8 Culex pipiens complex; Culex pipiens molestus; Culex pipiens pallens; Species diversity WEST NILE VIRUS; DIPTERA-CULICIDAE; VECTOR; INTROGRESSION; TRANSMISSION; DYNAMICS; DISEASE; AREAS; URBAN Culex pipiens complex; Culex pipiens molestus; Culex pipiens pallens; Species diversity English 2022 2022-08 10.1111/1748-5967.12610 바로가기 바로가기 바로가기 바로가기
Article The Neuropeptide Spexin Promotes the Osteoblast Differentiation of MC3T3-E1 Cells via the MEK/ERK Pathway and Bone Regeneration in a Mouse Calvarial Defect Model BACKGROUND: The neural regulation of bone regeneration has emerged recently. Spexin (SPX) is a novel neuropeptide and regulates multiple biological functions. However, the effects of SPX on osteogenic differentiation need to be further investigated. Therefore, the aim of this study is to investigate the effects of SPX on osteogenic differentiation, possible underlying mechanisms, and bone regeneration. METHODS: In this study, MC3T3-E1 cells were treated with various concentrations of SPX. Cell proliferation, osteogenic differentiation marker expressions, alkaline phosphatase (ALP) activity, and mineralization were evaluated using the CCK-8 assay, reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR), ALP staining, and alizarin red S staining, respectively. To determine the underlying molecular mechanism of SPX, the phosphorylation levels of signaling molecules were examined via western blot analysis. Moreover, in vivo bone regeneration by SPX (0.5 and 1 mu g/mu l) was evaluated in a calvarial defect model. New bone formation was analyzed using micro-computed tomography (micro-CT) and histology. RESULTS: The results indicated that cell proliferation was not affected by SPX. However, SPX significantly increased ALP activity, mineralization, and the expression of genes for osteogenic differentiation markers, including runt-related transcription factor 2 (Runx2), Alp, collagen alpha-1(I) chain (Col1a1), osteocalcin (Oc), and bone sialoprotein (Bsp). In contrast, SPX downregulated the expression of ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1). Moreover, SPX upregulated phosphorylated mitogen-activated protein kinase kinase (MEK1/2) and extracellular signal-regulated kinase (ERK1/2). In vivo studies, micro-CT and histologic analysis revealed that SPX markedly increased a new bone formation. CONCLUSION: Overall, these results demonstrated that SPX stimulated osteogenic differentiation in vitro and increased in vivo bone regeneration via the MEK/ERK pathway. Assefa, Freshet; Kim, Ju Ang; Lim, Jiwon; Nam, Sang-Hyeon; Shin, Hong-In; Park, Eui Kyun Kyungpook Natl Univ, Sch Dent, Dept Oral Pathol & Regenerat Med, 2177 Dalgubeol Daero, Daegu 41940, South Korea ; Kim, Ju Ang/LWI-0914-2024 57219236123; 55991948000; 13404844200; 57209806061; 24377179200; 37071072400 epark@knu.ac.kr; TISSUE ENGINEERING AND REGENERATIVE MEDICINE TISSUE ENG REGEN MED 1738-2696 2212-5469 19 1 SCIE CELL & TISSUE ENGINEERING;ENGINEERING, BIOMEDICAL 2022 3.6 50.5 1.29 2025-06-25 13 12 Neuropeptide; Spexin; Bone regeneration; MEK; ERK pathway SENSORY INNERVATION; GENE-EXPRESSION; PEPTIDE; RAT; MINERALIZATION; RECEPTOR; REGULATOR Bone regeneration; MEK/ERK pathway; Neuropeptide; Spexin Animals; Bone Regeneration; Cell Differentiation; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Neuropeptides; Osteoblasts; Osteogenesis; X-Ray Microtomography; Bone; Computerized tomography; Defects; Electrophoresis; Mineralogy; Phosphatases; Phosphorylation; Polymerase chain reaction; Transcription; alizarin red s; alkaline phosphatase; collagen type I alpha 1 chain; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; neuropeptide; osteocalcin; spexin; transcription factor RUNX2; unclassified drug; mitogen activated protein kinase kinase; neuropeptide; Bone regeneration; Calvarial defects; Defect model; Differentiation markers; In-vivo; MC3T3-E1 cell; MEK/ERK pathway; Neuropeptides; Osteogenic differentiation; Spexin; Alp gene; animal cell; animal experiment; animal model; animal tissue; Article; bone regeneration; Bsp gene; cell differentiation; cell proliferation; Col1a1 gene; controlled study; down regulation; drug effect; Enpp1 gene; enzyme phosphorylation; gene expression; histology; in vivo study; male; MAPK signaling; MC3T3-E1 cell line; micro-computed tomography; mineralization; mouse; nonhuman; Oc gene; ossification; osteoblast; quantitative analysis; reverse transcription polymerase chain reaction; Runx2 gene; skull defect; staining; upregulation; Western blotting; animal; bone development; bone regeneration; cell differentiation; MAPK signaling; metabolism; osteoblast; Cell proliferation English 2022 2022-02 10.1007/s13770-021-00408-2 바로가기 바로가기 바로가기 바로가기
Article A Novel Front-hauling Architecture under Centralized Radio Access Network (C-RAN) power line is considered a cost-effective communication media for building a digital indoor distributed network thanks to its ubiquity in the indoor environment. This paper investigates a front-hauling system under the split centralized radio access network (C-RAN) architecture, aiming to examine the feasibility of implementing common public radio interface (CPRI) over power line communication (PLC) channels. Particularly, we introduce a novel device called CPRI-PLC gateway (CPG) that provides a virtual CPRI link over the PLC channel to ensure high reliability and efficiency in delivering the CPRI hyper-frames (HFs) between the data unit (DU) and radio unit (RU). We examine the proposed CPRI over PLC system via extensive simulations in terms of the achievable throughput and reliability. Mei, Haoran; Hassan, Mai; Peng, Limei; Ho, Pin -Han Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea; Univ Waterloo, Dept Elect & Comp Engn, Waterloo, ON, Canada ; Ibrahim, Mai/JTT-3093-2023 57208655106; 58276785000; 7201574271; 7402211578 auroraplm@knu.ac.kr;p4ho@uwaterloo.ca; JOURNAL OF COMMUNICATIONS AND NETWORKS J COMMUN NETW-S KOR 1229-2370 1976-5541 24 3 SCIE COMPUTER SCIENCE, INFORMATION SYSTEMS;TELECOMMUNICATIONS 2022 3.6 50.6 0.08 2025-06-25 1 1 Centralized radio access network (C-RAN); common public radio interface (CPRI); front-haul; hybrid automatic repeat request (H-ARQ); impulsive noise detection & re-transmission (IND-Re); power line communication (PLC) IMPULSIVE NOISE Centralized radio access network (C-RAN); common public radio interface (CPRI); front-haul; hybrid automatic repeat request (H-ARQ); impulsive noise detection & re-transmission (IND-Re); power line communication (PLC) Carrier transmission on power lines; Electric power transmission; Error correction; Gateways (computer networks); Impulse noise; Network architecture; Radio access networks; Radio transmission; Centralised; Centralized radio access network; Common public radio interface; Front-haul; Hybrid automatic repeat request; Hybrid-automatic repeat request; Impulsive noise detection; Impulsive noise detection & re-transmission; Power line communication; Power lines; Radio access networks; Radio interface; Cost effectiveness English 2022 2022-06 10.23919/jcn.2022.000003 바로가기 바로가기 바로가기 바로가기
Article Blockchain-enabled secure communication mechanism for IoT-driven personal health records The information system of healthcare operates through various frameworks, like wireless body area network, telecare medical information system, and mobile or electronic healthcare. All these systems need to maintain the personal health records (PHRs) for various users (ie, patients, doctors, and nurses). In such systems, we need to process and store the health related sensitive data (ie, PHRs). In this article, we aim to provide a robust security mechanism to secure exchange and storage of healthcare data, especially PHRs. We present a generic architecture of blockchain-enabled secure communication mechanism for Internet of Things-driven personal health records (BIPHRS). We then discuss various threats and security attacks of healthcare system along with different available security mechanisms. The conducted security analysis and detailed comparative study of the state of art blockchain enabled security schemes for PHR systems show that the proposed BIPHRS provides a better security and more functionality features as compared to other similar existing approaches. Wazid, Mohammad; Das, Ashok Kumar; Park, Youngho Graph Era Deemed Univ, Dept Comp Sci & Engn, Dehra Dun, Uttarakhand, India; Int Inst Informat Technol, Ctr Secur Theory & Algorithm Res, Hyderabad 500032, India; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea WAZID, MOHAMMAD/X-4211-2018; Das, Ashok Kumar/U-2790-2019 55480987400; 55450732800; 56962990300 iitkgp.akdas@gmail.com; TRANSACTIONS ON EMERGING TELECOMMUNICATIONS TECHNOLOGIES T EMERG TELECOMMUN T 2161-3915 33 4 SCIE TELECOMMUNICATIONS 2022 3.6 50.6 0.63 2025-06-25 7 8 USER AUTHENTICATION SCHEME; PROTOCOL; MANAGEMENT; INTERNET Data communication systems; Digital storage; Health care; Information use; Internet of things; Medical information systems; Network security; Secure communication; Wireless networks; Block-chain; Communication mechanisms; Electronic healthcare; Generic architecture; Personal health record; Robust security; Security mechanism; Sensitive datas; Telecare; Wireless body area network; Blockchain English 2022 2022-04 10.1002/ett.4421 바로가기 바로가기 바로가기 바로가기
Article Coordinated throughput optimization for mobile sensor networks under heterogeneous fading conditions This paper considers the P2P throughput optimization of mobile wireless sensor networks under a Rician/Rayleigh heterogeneous fading environment. The Rician/Rayleigh fading scenarios considers both extreme cases of signal propagation, that is, dominant line of sight (LOS) signal and No LOS (NLOS) signal. We focus on a type of P2P communication between wireless sensor nodes where the desired signal experiences Rician fading channel and the interfering signals undergoes Rayleigh fading channel. The coordinated link quality- and position-aware route (C-LPAR) reconfiguration strategy is proposed to exploit the multipath fading characteristics and mobility of nodes in order to provide optimal end-to-end throughput routes in presence of path loss, fading and interference. We studied the performance of proposed strategy under different environmental conditions and investigated the achievable throughput as well as number of hops and euclidean distance of the routes. Fida, Adnan; Iftikhar, Adnan; Azfar Yaqub, Muhammad; Kim, Dongkyun COMSATS Univ, Dept Elect & Comp Engn, Islamabad, Pakistan; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea ; Yaqub, Muhammad Azfar/A-6965-2015 56437999500; 55605583300; 56735926100; 35753648800 dongkyun@knu.ac.kr; TRANSACTIONS ON EMERGING TELECOMMUNICATIONS TECHNOLOGIES T EMERG TELECOMMUN T 2161-3915 33 2 SCIE TELECOMMUNICATIONS 2022 3.6 50.6 0.08 2025-06-25 0 1 Communication aware routing; Mobility; Particle swarm optimization; Rician; Rayleigh fading channel; Throughput optimization WIRELESS; COMMUNICATION; CAPACITY; SYSTEMS Communication aware routing; Mobility; Particle swarm optimization; Rician/Rayleigh fading channel; Throughput optimization Fading channels; Peer to peer networks; Sensor nodes; Achievable throughputs; Environmental conditions; Fading characteristics; Line of sight signals; Mobile sensor networks; Mobile wireless sensor network; Rician fading channel; Throughput optimization; Rayleigh fading English 2022 2022-02 10.1002/ett.4096 바로가기 바로가기 바로가기 바로가기
Article Cost- and comfort-aware aggregated modified least slack time-based domestic power scheduling for residential communities Emergence of smart grid notion has revolutionized energy consumption patterns and energy conservation strategies of end users by addressing the broadening gap between electricity demand and supply. Accordingly, domestic appliance scheduling came into the play, gaining phenomenal popularity owing to its consideration on sustainable energy, user behaviors, and varying electricity tariff. To maximize the desired benefits of appliance scheduling, herein, we propose a least slack time (LST)-based scheduling algorithm embedded with consumption thresholds, which minimizes cost on grid electricity, while maximizing user comfort and sustainable energy usage. A modified LST (M-LST) algorithm was experimented for a multiple-house scenario with 100 houses. Simulated results were compared with an instance without scheduling and an instance of an existing scheduling scheme based on value on lost load. Renewable energy sources aggregated to M-LST further improves performance through aggregated M-LST (M-LST(A)). Results confirmed the remarkable superiority of the proposed M-LST(A) in reducing electricity bill, waiting time, peak load, and peak-to-average ratio. Silva, Bhagya Nathan; Lee, Kyuchang; Yoon, Yongtak; Han, Jihun; Cao, ZhenBo; Han, Kijun Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea Silva, Bhagya/AAW-1014-2021 57192304387; 57213678506; 56996617600; 8644262600; 57145726600; 7402963670 kjhan@knu.ac.kr; TRANSACTIONS ON EMERGING TELECOMMUNICATIONS TECHNOLOGIES T EMERG TELECOMMUN T 2161-3915 33 2 SCIE TELECOMMUNICATIONS 2022 3.6 50.6 0.24 2025-06-25 4 4 DEMAND-SIDE MANAGEMENT; ENERGY MANAGEMENT; LOAD MANAGEMENT; SMART; ELECTRICITY; OPTIMIZATION; GAME; APPLIANCES; SYSTEM Behavioral research; Domestic appliances; Electric power transmission networks; Energy conservation; Energy utilization; Renewable energy resources; Scheduling; Conservation strategies; Electricity demands; Electricity tariff; Peak to average ratios; Renewable energy source; Residential communities; Scheduling schemes; Sustainable energy; Smart power grids English 2022 2022-02 10.1002/ett.3834 바로가기 바로가기 바로가기 바로가기
Article Intelligent Internet of Things gateway supporting heterogeneous energy data management and processing The requisition for electrical energy, smart grid, and renewable energy paradigm extend a new space for Electrical Energy Data Management and Processing Systems (EEDMS), in such a way that can mitigate the consumption of electrical energy. Similarly, the implementation and maintenance of the EEDMS is a challenging task. Moreover, the heterogeneous energy data generated from residential and commercial sector are the leading challenges for standard Internet of Things (IoT) architecture. This contributes enormous energy data preprocessing and analyzing solutions to IoT landscape. To overcome these challenges, we present a scalable multitasking Internet of Things Gateway (IoTGW) for the modern era of IoT by placing reliance on a new entity called Data Loading and Storing Module (DLSM). The provided DLSM module combine with the Gateway module services like orchestrator, flexibility of bridging front end grid, back end grid and fast formatted data trade between sensing domain and application domain enables a high dynamic distributed framework. Specifically, we add Adaboost-Multilayer Perceptron hybrid data classifier module to the proposed work to enhance service provision of IoT gateway toward various IoT application services and protocols to facilitate IoT demands such as multitasking, interoperability, classification, and fast data delivery between different modules. IoTGW is implemented and tested using a real-time IoT data streaming network. The experimental results confirms the superiority of proposed work in terms of scalability to serve novel applications and facilitate broad scope of IoT. Diyan, Muhammad; Silva, Bhagya Nathali; Han, Jihun; Cao, ZhenBo; Han, Kijun Kyungpook Natl Univ, Sch Comp Sci & Engn, 80 Daehakro, Daegu 41566, South Korea Cao, Zhenbo/AAA-3489-2022; Silva, Bhagya/AAW-1014-2021; Diyan, Muhammad/AAM-5848-2021 26028317800; 57192304387; 8644262600; 57145726600; 7402963670 kjhan@knu.ac.kr; TRANSACTIONS ON EMERGING TELECOMMUNICATIONS TECHNOLOGIES T EMERG TELECOMMUN T 2161-3915 33 2 SCIE TELECOMMUNICATIONS 2022 3.6 50.6 1.26 2025-06-25 18 17 ALGORITHM; SYSTEMS Adaptive boosting; Classification (of information); Data handling; Electric power transmission networks; Gateways (computer networks); Information management; Interoperability; Multilayer neural networks; Multitasking; Smart power grids; Commercial sector; Distributed framework; Energy data managements; Internet of Things (IOT); Novel applications; Processing systems; Renewable energies; Service provisions; Internet of things English 2022 2022-02 10.1002/ett.3919 바로가기 바로가기 바로가기 바로가기
Article Predicting factor analysis of postoperative complications after robot-assisted radical cystectomy: Multicenter KORARC database study Objectives To evaluate postoperative complications following robot-assisted radical cystectomy in patients diagnosed with bladder cancer and reveal if there are predictors for postoperative complications. Methods Prospectively collected medical records of 730 robot-assisted radical cystectomy patients between 2007/04 and 2019/05 in 13 tertiary referral centers were reviewed. Perioperative outcomes were compared between two groups by postoperative complications (complication vs non-complication). We assessed recurrence-free survival, cancer-specific survival, and overall survival between groups. Regression analyses were implemented to identify factors associated with postoperative complications. Results Any total and high-grade complication (Clavien-Dindo grade >= 3) rates were 57.8% and 21.1%, respectively. Patients in complication group had significantly higher proportion of diabetes mellitus (P = 0.048), chronic kidney disease (P = 0.011), dyslipidemia (P < 0.001), longer operation time (P = 0.001), more estimated blood loss (P = 0.001), and larger intraoperative fluid volume (P < 0.001). There was a significant difference in cancer-specific survival (log-rank P = 0.038, median cancer-specific survival: both groups not reached). Dyslipidemia (odds ratio 2.59, P = 0.002) and intraoperative fluid volume (odds ratio 1.0002, P = 0.040) were significantly associated with high-grade postoperative complications. Diabetes mellitus (odds ratio 1.97, P = 0.028), chronic kidney disease (odds ratio 1.89, P = 0.046), dyslipidemia (odds ratio 5.94, P = 0.007), and intraoperative fluid volume (odds ratio 1.0002, P = 0.009) were significantly associated with any postoperative complications. Conclusions Patients with diabetes mellitus, chronic kidney disease, dyslipidemia, or a relatively large intraoperatively infused fluid volume are more likely to develop postoperative complications. Patients with postoperative complications might have a possibility of lower cancer-specific survival rate. Kim, Hwanik; Jeong, Byong Chang; Lee, Sangchul; Ku, Ja Hyeon; Kwon, Tae Gyun; Kim, Tae-Hwan; Jeon, Seung Hyun; Lee, Sang Hyub; Nam, Jong Kil; Kim, Wansuk; Lee, Ji Youl; Hong, Sung Hoo; Rha, Koon Ho; Han, Woong Kyu; Ham, Won Sik; Lee, Young Goo; Lee, Yong Seong; Park, Sung Yul; Yoon, Young Eun; Kang, Sung Gu; Kang, Seok Ho; Oh, Jong Jin Seoul Natl Univ, Dept Urol, Bundang Hosp, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Urol, Sch Med, Seoul, South Korea; Seoul Natl Univ, Dept Urol, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Urol, Sch Med, Daegu, South Korea; Kyung Hee Univ, Dept Urol, Sch Med, Seoul, South Korea; Pusan Natl Univ, Dept Urol, Yangsan Hosp, Yangsan, South Korea; Inje Univ, Busan Paik Hosp, Dept Urol, Coll Med, Busan, South Korea; Catholic Univ Korea, Dept Urol, Coll Med, Seoul St Marys Hosp, Seoul, South Korea; Yonsei Univ, Severance Hosp, Dept Urol, Coll Med, Seoul, South Korea; Hallym Univ, Sch Med, Dept Urol, Kangnam Sacred Heart Hosp, Seoul, South Korea; Hallym Univ, Coll Med, Dept Urol, Sacred Heart Hosp, Anyang, South Korea; Hanyang Univ, Dept Urol, Coll Med, Seoul, South Korea; Korea Univ, Dept Urol, Coll Med, Seoul, South Korea Yoon, Youngeun/HOC-1137-2023; Lee, Hye/J-2154-2015; Kim, Hwanik/HME-0816-2023; Ku, Ja/E-6682-2016; JY, LEE/GRS-9767-2022; Jeon, Seung Hyun/AFN-3212-2022 56080537500; 7102237943; 57202327303; 36800523000; 15073765400; 57889057300; 7203005251; 57265524000; 8653467500; 57049819200; 57202074202; 37030299600; 7003388459; 7401899857; 23097952400; 15033760000; 36068330000; 57207888185; 58825663400; 35995660400; 7405684686; 24468588100 bebsuzzang@naver.com; INTERNATIONAL JOURNAL OF UROLOGY INT J UROL 0919-8172 1442-2042 29 9 SCIE UROLOGY & NEPHROLOGY 2022 2.6 50.6 0.88 2025-06-25 5 5 bladder cancer; minimally invasive surgical procedures; postoperative complications; radical cystectomy; robotic surgical procedures BLADDER-CANCER; ENHANCED RECOVERY; OUTCOMES; CLASSIFICATION; SURGERY; IMPACT bladder cancer; minimally invasive surgical procedures; postoperative complications; radical cystectomy; robotic surgical procedures Cystectomy; Factor Analysis, Statistical; Humans; Postoperative Complications; Renal Insufficiency, Chronic; Retrospective Studies; Robotic Surgical Procedures; Robotics; Treatment Outcome; Urinary Bladder Neoplasms; adult; aged; Article; bladder cancer; cancer mortality; cancer specific survival; cancer surgery; cardiovascular disease; chronic kidney failure; comparative study; controlled study; diabetes mellitus; dyslipidemia; enhanced recovery after surgery; factor analysis; female; gastrointestinal disease; genetic database; hematologic disease; hospital readmission; human; lung complication; major clinical study; male; medical record review; neoadjuvant chemotherapy; neurologic disease; operation duration; operative blood loss; overall survival; perioperative period; postoperative complication; postoperative infection; prospective study; recurrence free survival; regression analysis; robot-assisted radical cystectomy; tertiary care center; urinary tract disease; vascular disease; wound complication; adverse event; bladder tumor; chronic kidney failure; clinical trial; cystectomy; multicenter study; postoperative complication; retrospective study; robot assisted surgery; robotics; treatment outcome English 2022 2022-09 10.1111/iju.14815 바로가기 바로가기 바로가기 바로가기
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Publication Year 논문이 출판된 연도입니다.
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