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| ○ | ○ | Article | Impact of COVID-19 outbreak on acute gallbladder disease in the emergency department | Objective Acute gallbladder disease (AGD) is frequent in the emergency department (ED) and usually requires emergency surgery. However, only a few studies have reported the impact of COVID-19 on AGD. The goal of this study was to evaluate the time between symptom onset and surgery and the perioperative severity of AGD during the COVID-19 pandemic compared to be-fore the era of COVID-19. Methods This retrospective, single-center cohort study included patients who presented to the ED with suspected AGD and who underwent emergency cholecystectomy. We designed a before -after comparative study, and the intervention was the COVID-19 outbreak. The 6-month period after the COVID-19 outbreak was defined as the post-COVID group, whereas the pre-COVID group consisted of the same period in the previous year. The primary outcome was the time from symptoms to surgery. We evaluated the time intervals between symptom onset and ED arrival and between ED arrival and surgery. The secondary outcomes were preoperative and postopera-tive severity indexes. Results A total of 316 patients was analyzed. The post-COVID group showed longer duration from symptom onset to ED arrival (34.0 hours vs. 15.0 hours, P< 0.001) and longer time interval from ED arrival to surgery (16.2 hours vs. 10.2 hours, P< 0.001) than the pre-COVID group. The overall time interval between symptom onset to surgery was longer in the post-COVID group than the pre-COVID group (71.5 hours vs. 33.5 hours, P< 0.001). The post-COVID group showed higher preoperative Simplified Acute Physiology Score II scores than the pre-COVID group (20.1 vs. 18.2, P=0.045). The proportion of moderate or severe disease increased in the post-COVID group (78% vs. 65%, P=0.017). The durations of hospital stay (7.0 days vs. 5.0 days, P< 0.001) and intensive care unit stay (27.1 hours vs. 10.8 hours, P= 0.008) were longer in the post-COVID group than in the pre-COVID group. Conclusion During the pandemic, the time interval between symptom onset to surgery was sig-nificantly increased among patients with AGD. Concomitantly, higher preoperative severity in-dexes and longer hospital stay were reported with a delay in emergency surgery. | Sakong, Dal; Choe, Michael Sung Pil; Nho, Woo Young; Park, Chang Won | CHA Univ, CHA Bundang Med Ctr, Dept Emergency Med, Seongnam, South Korea; CHA Univ, CHA Gumi Med Ctr, Dept Emergency Med, Sch Med, Gumi, South Korea; Kyungpook Natl Univ, Dept Emergency Med, Sch Med, Daegu, South Korea; Daegu Fatima Hosp, Dept Emergency Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Emergency Med, Sch Med, 680 Gukchaebosang Ro, Daegu, South Korea | Nho, Woo Young/JLN-0752-2023 | 58195284800; 57189643732; 57215831839; 57917945800 | wooyoung.nho@gmail.com; | CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE | CLIN EXP EMERG MED | 2383-4625 | 10 | 1 | ESCI | EMERGENCY MEDICINE | 2023 | 1.9 | 38.0 | 2.13 | 2025-06-25 | 6 | 6 | Acute cholecystitis; COVID-19; Pandemics; Cholecystectomy | ACUTE CHOLECYSTITIS; MANAGEMENT; OUTCOMES | Acute cholecystitis; Cholecystectomy; COVID-19; Pandemics | acute acalculous cholecystitis; acute calculous cholecystitis; acute cholecystitis; acute disease; acute gangrenous cholecystitis; acute suppurative cholecystitis; adult; aged; APACHE; Article; cholecystectomy; cohort analysis; comparative study; complicated acute cholecystitis; coronavirus disease 2019; disease severity; emergency surgery; emergency ward; gallbladder disease; hospital readmission; hospitalization; human; intensive care unit; length of stay; male; operation duration; pandemic; postoperative severity index; preoperative period; preoperative severity index; preoperative simplified acute physiology score 2; retrospective study; Sequential Organ Failure Assessment Score; Simplified Acute Physiology Score; time from symptoms to surgery; time intervals between emergency department arrival and surgery; time intervals between symptom onset and emergency department arrival | English | 2023 | 2023-03 | 10.15441/ceem.22.239 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Resistant hypertension: consensus document from the Korean society of hypertension | Although reports vary, the prevalence of true resistant hypertension and apparent treatment-resistant hypertension (aTRH) has been reported to be 10.3% and 14.7%, respectively. As there is a rapid increase in the prevalence of obesity, chronic kidney disease, and diabetes mellitus, factors that are associated with resistant hypertension, the prevalence of resistant hypertension is expected to rise as well. Frequently, patients with aTRH have pseudoresistant hypertension [aTRH due to white-coat uncontrolled hypertension (WUCH), drug underdosing, poor adherence, and inaccurate office blood pressure (BP) measurements]. As the prevalence of WUCH is high among patients with aTRH, the use of out-of-office BP measurements, both ambulatory blood pressure monitoring (ABPM) and home blood pressure monitoring (HBPM), is essential to exclude WUCH. Non-adherence is especially problematic, and methods to assess adherence remain limited and often not clinically feasible. Therefore, the use of HBPM and higher utilization of single-pill fixed-dose combination treatments should be emphasized to improve drug adherence. In addition, primary aldosteronism and symptomatic obstructive sleep apnea are quite common in patients with hypertension and more so in patients with resistant hypertension. Screening for these diseases is essential, as the treatment of these secondary causes may help control BP in patients who are otherwise difficult to treat. Finally, a proper drug regimen combined with lifestyle modifications is essential to control BP in these patients. | Park, Sungha; Shin, Jinho; Ihm, Sang Hyun; Kim, Kwang-il; Kim, Hack-Lyoung; Kim, Hyeon Chang; Lee, Eun Mi; Lee, Jang Hoon; Ahn, Shin Young; Cho, Eun Joo; Kim, Ju Han; Kang, Hee-Taik; Lee, Hae-Young; Lee, Sunki; Kim, Woohyeun; Park, Jong-Moo | Yonsei Univ, Severance Cardiovasc Hosp, Integrat Res Ctr Cerebrovasc & Cardiovasc Dis, Div Cardiol,Coll Med, Seoul, South Korea; Hanyang Univ, Seoul Hosp, Dept Internal Med, Div Cardiol, Seoul, South Korea; Catholic Univ Korea, Bucheon St Marys Hosp, Dept Internal Med, Div Cardiol,Coll Med, Bucheon, South Korea; Catholic Univ Korea, Bucheon St Marys Hosp, Catholic Res Inst Intractable Cardiovasc Dis, Coll Med, 327 Sosa Ro, Bucheon Si 14647, Gyunggi Do, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, Seongnam, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Div Cardiol,Coll Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; Wonkwang Univ, Sanbon Hosp, Coll Med, Div Cardiol,Dept Internal Med, Gunpo, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Div Nephrol, Seoul, South Korea; Catholic Univ Korea, Dept Internal Med, Div Cardiol, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Cardiovasc Med, Gwangju, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Dept Family Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Hallym Univ, Dongtan Hosp, Gyeonggi Do, South Korea; Hanyang Univ, Dept Internal Med, Div Cardiol, Seoul Hosp, Seoul, South Korea; Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Neurol, Uijongbu, South Korea | Kim, Kwang-il/AAP-7315-2021; Lee, Jae/W-5616-2018; Kim, Hack-Lyoung/AAL-5038-2020; Kim, Hyeon/F-8796-2019; Kim, Hyeon Chang/F-8796-2019; CHIA, YOOK CHIN/B-8379-2010 | 8556278400; 54791393300; 7005028587; 57193847032; 17135448100; 8540942600; 57199433199; 54581258000; 55313081300; 57212426414; 57196169644; 37101607600; 56151235500; 55642622400; 55642474800; 8407334400 | limsh@catholic.ac.kr; | CLINICAL HYPERTENSION | CLIN HYPERTENS | 2056-5909 | 29 | 1 | ESCI | PERIPHERAL VASCULAR DISEASE | 2023 | 2.6 | 38.0 | 0.84 | 2025-06-25 | 9 | 9 | Ambulatory blood pressure monitoring; Home blood pressure monitoring; Hypertension; Refractory hypertension; Resistant hypertension | OBSTRUCTIVE SLEEP-APNEA; HIGH-BLOOD-PRESSURE; ROSTRAL FLUID SHIFT; RENAL DENERVATION; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; MEDICATION ADHERENCE; HIGH PREVALENCE; DIETARY-SODIUM; RISK-FACTORS | Ambulatory blood pressure monitoring; Home blood pressure monitoring; Hypertension; Refractory hypertension; Resistant hypertension | adolescent; adult; aerobic exercise; alcohol consumption; aldosterone blood level; aldosterone release; antihypertensive therapy; arterial stiffness; blood pressure; blood pressure measurement; blood pressure monitoring; body mass; body position; computed tomographic angiography; consensus; evaluation study; fluid retention; follow up; general practitioner; glomerulus filtration; healthy lifestyle; human; hydrocortisone urine level; laboratory test; lifestyle modification; magnetic resonance angiography; medical examination; medical society; medication compliance; parathyroid gland; passive smoking; physical activity; physical examination; physical inactivity; plasma renin activity; polypharmacy; pressoreceptor reflex; prevalence; renin angiotensin aldosterone system; resistant hypertension; Review; salt intake; screening test; sleep quality; smokeless tobacco; sodium intake; tertiary care center; treadmill exercise; treatment refusal; tunica albuginea | English | 2023 | 2023-11-01 | 10.1186/s40885-023-00255-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | The 2022 focused update of the 2018 Korean Hypertension Society Guidelines for the management of hypertension | Hypertension is the leading cause of death in human being, which shows high prevalence and associated complications that increase the mortality and morbidity. Controlling blood pressure (BP) is very important because it is well known that lowering high BP effectively improves patients' prognosis. This review aims to provide a focused update of the 2018 Korean Hypertension Society Guidelines for the management of hypertension. The importance of ambulatory BP and home BP monitoring was further emphasized not only for the diagnosis but also for treatment target. By adopting corresponding BPs, the updated guideline recommended out-of-office BP targets for both standard and intensive treatment. Based on the consensus on corresponding BPs and Systolic Blood Pressure Intervention Trial (SPRINT) revisit, the updated guidelines recommended target BP in high-risk patients below 130/80 mmHg and it applies to hypertensive patients with three or more additional cardiovascular risk factors, one or more risk factors with diabetes, or hypertensive patients with subclinical organ damages, coronary or vascular diseases, heart failure, chronic kidney disease with proteinuria, and cerebral lacunar infarction. Cerebral infarction and chronic kidney disease are also high-risk factors for cardiovascular disease. However, due to lack of evidence, the target BP was generally determined at < 140/90 mmHg in patients with those conditions as well as in the elderly. Updated contents regarding the management of hypertension in special situations are also discussed. | Kim, Hack-Lyoung; Lee, Eun Mi; Ahn, Shin Young; Kim, Kwang-il; Kim, Hyeon Chang; Kim, Ju Han; Lee, Hae-Young; Lee, Jang Hoon; Park, Jong-Moo; Cho, Eun Joo; Park, Sungha; Shin, Jinho; Kim, Young-Kwon | Seoul Natl Univ, Seoul Metropolitan Govt Seoul Natl Univ Boramae Me, Dept Internal Med, Coll Med, Seoul, South Korea; Wonkwang Univ, Sanbon Hosp, Dept Internal Med, Sch Med, Gunpo, South Korea; Korea Univ, Coll Med, Dept Internal Med, Guro Hosp, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Yonsei Univ, Dept Prevent Med, Coll Med, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju, South Korea; Seoul Natl Univ Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Neurol, Uijongbu, South Korea; Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Internal Med, Yeouido St, Seoul, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Med Ctr, Seoul, South Korea; Dongguk Univ, Sch Med, Dept Internal Med, Ilsan Hosp, Seoul, South Korea | Kim, Kwang-il/D-8024-2012; Lee, Hye-Young/JEP-8044-2023; Kim, Hyeon/F-8796-2019; CHIA, YOOK CHIN/B-8379-2010; Kim, Hack-Lyoung/AAL-5038-2020; Kim, Kwang-il/AAP-7315-2021; Kim, Hyeon Chang/F-8796-2019; Lee, Jae/W-5616-2018 | 17135448100; 57199433199; 55313081300; 57193847032; 8540942600; 57196169644; 56151235500; 54581258000; 8407334400; 57212426414; 8556278400; 57222486697; 36078857300 | e-ykkim@hanmail.net; | CLINICAL HYPERTENSION | CLIN HYPERTENS | 2056-5909 | 29 | 1 | ESCI | PERIPHERAL VASCULAR DISEASE | 2023 | 2.6 | 38.0 | 7.39 | 2025-06-25 | 82 | 80 | Blood pressure; Guideline; Hypertension; Korea | AMBULATORY BLOOD-PRESSURE; FIXED-DOSE COMBINATIONS; CHRONIC KIDNEY-DISEASE; MASKED UNCONTROLLED HYPERTENSION; ANGIOTENSIN SYSTEM INHIBITORS; CONVERTING ENZYME-INHIBITOR; CALCIUM-CHANNEL BLOCKER; WHITE-COAT HYPERTENSION; DOUBLE-BLIND; ATRIAL-FIBRILLATION | Blood pressure; Guideline; Hypertension; Korea | antihypertensive agent; antihypertensive therapy; blood pressure measurement; blood pressure monitoring; cardiovascular risk factor; chronic kidney failure; consensus; coronary artery disease; diabetes mellitus; heart failure; high risk patient; human; hypertension; hypertensive patient; Korea; lacunar infarction; medical society; morbidity; mortality; practice guideline; prevalence; prognosis; proteinuria; Review; risk assessment; systolic blood pressure; treatment planning | English | 2023 | 2023-02-15 | 10.1186/s40885-023-00234-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Complementary FET (CFET) Standard Cell Design for Low Parasitics and Its Impact on VLSI Prediction at 3-nm Process | Complementary field-effect transistor (CFET) is a future transistor type with a high potential to be used beyond 3-nm technology nodes. Despite its high future value, studies related to CFETs mostly focused on the device aspects. In other words, the path of CFET full-chip IC design is not fully demystified, knowing that various design factors/steps (such as schematic, layout, parasitics, design flow) must be considered on top of device traits for full-chip level IC. Therefore, this study focuses on enlightening the remaining factors/steps for full-chip IC design. In detail, we notify the importance of parasitics from various aspects of CFET design and provide optimization solutions. Compared to nanosheet FET (NSFET) on the full-chip scale, CFET shows a reduction of the area by -48.2%, power by -29.4%, total wirelength by -32.5%, and the number of cells by -18.1%. © 1993-2012 IEEE. | Park, Eunbin; Song, Taigon | Pohang University of Science and Technology (POSTECH), Department of Electrical Engineering, Pohang, 37673, South Korea; Kyungpook National University (KNU), School of Electronics Engineering, Daegu, 41566, South Korea | 57424580800; 36005021000 | tsong@knu.ac.kr; | IEEE Transactions on Very Large Scale Integration (VLSI) Systems | IEEE T VLSI SYST | 1063-8210 | 1557-9999 | 31 | 2 | SCIE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;ENGINEERING, ELECTRICAL & ELECTRONIC | 2023 | 2.8 | 38.1 | 2.08 | 2025-06-25 | 18 | Complementary field-effect transistor (CFET); library; N3; parasitic analysis; process design kit (PDK); standard cell | FinFET; Integrated circuit layout; Latexes; Business process reengineering; Complementary field-effect transistor; Field-effect transistor; FinFETs; Layout; Parasitic analyse; Parasitics; Performances evaluation; Process design kit; Resistance; Standard-cell; Verylarge-scale integrations (VLSI); Integrated circuits | English | Final | 2023 | 10.1109/tvlsi.2022.3220339 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | Article | NS3K: A 3-nm Nanosheet FET Standard Cell Library Development and its Impact | Nanosheet FETs (NSFETs) are attracting attention as promising devices that can replace FinFETs beyond the 5-nm node. Despite the importance of the devices, few studies analyze the impact of NSFETs at the block-level. In this article, we introduce NS3K, the first 3-nm NSFET standard cell library, and examine the results on a block-level scale. In addition to the overall process of designing a full library, we extended the scope of the buried power rail (BPR) to better layout designs. We showed that BPR, originally proposed to overcome power delivery problems, is also an effective solution for standard cell hegith reductions. Using BPR, we highlight that 4-track height standard cell designs have a negligible impact on power delivery and signal routing. Overall chip results show that the 3-nm NSFET outperforms the 5-nm FinFET by -27.4% in power, -25.8% in total wirelength, -8.5% in the number of cells, -47.6% in area, and 34.7% performance, respectively, owing to better device performance and interconnect scaling. However, careful device/layout designs and new interconnect structures must be applied to continue the scaling trend and maximize the advantages of 3-nm technology. © 1993-2012 IEEE. | Kim, Taehak; Jeong, Jaehoon; Woo, Seungmin; Yang, Jeonggyu; Kim, Hyunwoo; Nam, Ahyeon; Lee, Changdong; Seo, Jinmin; Kim, Minji; Ryu, Siwon; Oh, Yoonju; Song, Taigon | Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronics Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronics Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronics Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronics Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronics Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronics Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronics Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronics Engineering, Daegu, 41566, South Korea; Kyungpook National University (KNU), School of Electronic and Electrical Engineering, Daegu, 41566, South Korea | 57225038681; 57226881576; 58064515100; 57221952581; 59862730600; 57225056284; 57225047441; 57225045041; 57127351600; 57225053925; 58459110300; 36005021000 | tsong@knu.ac.kr; | IEEE Transactions on Very Large Scale Integration (VLSI) Systems | IEEE T VLSI SYST | 1063-8210 | 1557-9999 | 31 | 2 | SCIE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;ENGINEERING, ELECTRICAL & ELECTRONIC | 2023 | 2.8 | 38.1 | 1.5 | 2025-06-25 | 13 | Buried power rail (BPR); FinFET; library; nanosheet; nanosheet FET (NSFET); standard cell | Nanosheets; Buried power rail; Business process reengineering; FinFETs; Layout; Layout designs; Nanosheet FET; Power delivery; Power rails; Routings; Standard-cell; FinFET | English | Final | 2023 | 10.1109/tvlsi.2022.3229442 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Application of optimized time domain reflectometry probe for estimating contaminants in saline soil | Monitoring contaminants in waste landfills on a seabed is important because the leachate affects the marine ecosystem and facility stability. The objective of this study is to optimize a time-domain reflectometry (TDR) probe using different coating materials and several electrodes to estimate contaminants in saline soil. Copper concentrations ranging from 0 mg/L to 10 mg/L were mixed in 3% salinity water to simulate contaminants in the ocean environment. Epoxy, top-coat, and varnish were used as coating materials, and two to seven electrodes were prepared to vary the number and arrangement of the electrodes. Test results showed that the varnish stably captured the increase in copper concentration, while the other coating materials became insensitive or caused leakage current. In addition, a TDR probe with more electrodes exhibited stable and distinct electromagnetic signals. Thus, the TDR probe with seven electrodes coated with varnish was effectively used to estimate contaminants in saline soil. | Lee, Dongsoo; Lee, Jong-Sub; Byun, Yong-Hoon; Kim, Sang Yeob | Korea Univ, Sch Civil Environm & Architectural Engn, 145 Anam Ro, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Agr Civil & Bioind Engn, 80 Daehak Ro, Daegu 41566, South Korea; Konkuk Univ, Dept Fire & Disaster Prevent, 268 Chungwon Daero, Chungju 27478, South Korea | Byun, Yong-Hoon/JKI-8441-2023; Lee, Jong-Sub/G-2752-2012 | 57483228200; 55690048400; 42761048000; 57202787920 | s3778@korea.ac.kr;sangyeob@kku.ac.kr; | GEOMECHANICS AND ENGINEERING | GEOMECH ENG | 2005-307X | 2092-6219 | 33 | 3 | SCIE | ENGINEERING, CIVIL;ENGINEERING, GEOLOGICAL | 2023 | 2.5 | 38.2 | 0.68 | 2025-06-25 | 5 | 6 | coating materials; copper concentration; electrodes; final converged voltage; time domain reflectometry | ELECTRICAL-CONDUCTIVITY; WATER-CONTENT; EPOXY; GROUNDWATER; PERMITTIVITY; TRANSPORT | coating materials; copper concentration; electrodes; final converged voltage; time domain reflectometry | Contamination; Ecosystems; Probes; Reflection; Reflectometers; Soils; Solvents; Coating material; Copper concentration; Final converged voltage; Leachates; Ocean environment; Saline soil; Salinity water; Time domain reflectometry; Time domain reflectometry probes; Waste landfill; Electrodes | English | 2023 | 2023-05-10 | 10.12989/gae.2023.33.3.291 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Influence of specimen height on the shear behavior of glass beads in the direct shear test | A box scale affects the shear behavior of soils in the direct shear test. The purpose of this study is to investigate the scale effect on the shear behavior of dilative granular materials by testing specimens of different heights placed in a type C shear box. Experimental tests were performed on specimens composed of glass beads with different heights and equal initial void ratios. Results showed that the peak friction and dilation angles linearly increased with the specimen height; however, the residual friction angle remained relatively constant. Similarly, the shear stiffness increased with the specimen height, rapidly reaching its peak state. Height does not have a significant effect on the total volume changes; nevertheless, a high aspect ratio can be assumed to result in global and homogeneous failure. The results and interpretations may be used as reference for recommending shear box scale in direct shear tests. | Hong, Young-Ho; Byun, Yong-Hoon; Lee, Jong-Sub | Korea Univ, Sch Civil Environm & Architectural Engn, 145 Anam Ro, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Agr Civil & Bioind Engn, 80 Daehak Ro, Daegu 41566, South Korea | Byun, Yong-Hoon/JKI-8441-2023; Lee, Jong-Sub/G-2752-2012 | 57164213100; 42761048000; 55690048400 | lovelymalpoy@korea.ac.kr;yhbyun@knu.ac.kr;jongsub@korea.ac.kr; | GEOMECHANICS AND ENGINEERING | GEOMECH ENG | 2005-307X | 2092-6219 | 34 | 4 | SCIE | ENGINEERING, CIVIL;ENGINEERING, GEOLOGICAL | 2023 | 2.5 | 38.2 | 0 | 2025-06-25 | 0 | 0 | direct shear test; glass beads; scale effect; shear behavior; shear stiffness | PLANE-STRAIN; STRENGTH; DILATANCY; SIZE; SIMULATIONS; LONDON; SANDS; CLAY; SOIL | direct shear test; glass beads; scale effect; shear behavior; shear stiffness | Aspect ratio; Friction; Glass; Shear flow; Stiffness; Different heights; Direct shear test; Experimental test; Friction angles; Glass bead; Initial void ratios; Scale effects; Shear behaviour; Shear box; Shear stiffness; Granular materials | English | 2023 | 2023-08-25 | 10.12989/gae.2023.34.4.461 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | 3D simulation of interosseous interference in sagittal split ramus osteotomy for mandibular asymmetry | Background The purpose of this study was to evaluate the pattern of predicted interosseous interference and to determine the influencing factor to volume of bony interference using a computer-assisted simulation system. This retrospective study recruited 116 patients with mandibular prognathism who had undergone sagittal split ramus osteotomy (SSRO) with or without maxillary osteotomy. The patients were divided into 3 groups according to the amount of menton (Me) deviation: less than 2 mm (Group 1), 2-4 mm (Group 2), and more than 4 mm (Group 3). Changes in the distal segments following BSSRO and the volume of the interosseous interference between the proximal and distal segments were simulated after matching preoperative occlusion and postoperative expected occlusion with the cone-beam computed tomography data. Ramal inclinations and other skeletal measurements were analyzed before surgery, immediately after surgery, and at least 6 months after surgery. Results The anticipated interosseous interference was more frequently noted on the contralateral side of chin deviation (long side) than the deviated site (short side) in Groups 2 and 3. More interference volume was predicted at the long side (186 +/- 343.9 mm(3)) rather than the short side (54.4 +/- 124.4 mm(3)) in Group 3 (p = 0.033). The bilateral difference in the volume of the interosseous interference of the osteotomized mandible was significantly correlated with the Me deviation (r = - 0.257, p = 0.009) and bilateral ramal inclination (r = 0.361, p < 0.001). The predictor variable that affected the volume of the osseous interference at each side was the amount of Me deviation (p = 0.010). Conclusion By using the 3D simulation system, the potential site of bony collision could be visualized and successfully reduced intraoperatively. Since the osseous interference can be existed on any side, unilaterally or bilaterally, 3D surgical simulation is necessary before surgery to predict the osseous interference and improve the ramal inclination. | Udayakumar, Santhiya Iswarya Vinothini; Kim, Dohyoung; Choi, So-Young; Kwon, Tae-Geon | Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, 2177 Dalgubeol Daero, Daegu 41940, South Korea | Udayakumar, Santhiya Iswarya Vinothini/AAR-2150-2021 | 57746259400; 58582057800; 57202918688; 35205433300 | kwondk@knu.ac.kr; | MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY | MAX PLAST RECONSTR S | 2288-8101 | 2288-8586 | 45 | 1 | ESCI | DENTISTRY, ORAL SURGERY & MEDICINE | 2023 | 2 | 38.3 | 0 | 2025-06-25 | 0 | 0 | Osteotomy; Sagittal split ramus; Asymmetry; Facial; Three-dimensional imaging; Computer assisted | ORTHOGNATHIC SURGERY; FACIAL ASYMMETRY; STABILITY; POSITION; SETBACK | Asymmetry; Computer assisted; Facial; Osteotomy; Sagittal split ramus; Three-dimensional imaging | adult; anatomical concepts; Article; computer simulation; cone beam computed tomography; face asymmetry; female; human; interosseous interference; major clinical study; male; mandible; medical parameters; occlusion; osteotomy; outcome assessment; prediction; predictor variable; preoperative evaluation; regression analysis; retrospective study; sagittal split osteotomy; simulation; skeletal measurement; software; three-dimensional imaging | English | 2023 | 2023-09-18 | 10.1186/s40902-023-00400-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Application of tree-based machine learning classification methods to detect signals of fluoroquinolones using the Korea Adverse Event Reporting System (KAERS) database | BackgroundSafety issues for fluoroquinolones have been provided by regulatory agencies. This study was conducted to identify signals of fluoroquinolones reported in the Korea Adverse Event Reporting System (KAERS) using tree-based machine learning (ML) methods.Research design and methodsAll adverse events (AEs) associated with the target drugs reported in the KAERS from 2013 to 2017 were matched with drug label information. A dataset containing label-positive and -negative AEs was arbitrarily divided into training and test sets. Decision tree, random forest (RF), bagging, and gradient boosting machine (GBM) were fitted on the training set with hyperparameters tuned using five-fold cross-validation and applied to the test set. The ML method with the highest area under the curve (AUC) scores was selected as the final ML model.ResultsBagging was selected as the final ML model for gemifloxacin (AUC score: 1) and levofloxacin (AUC: 0.9987). RF was selected in ciprofloxacin, moxifloxacin, and ofloxacin (AUC scores: 0.9859, 0.9974, and 0.9999 respectively). We found that the final ML methods detected additional signals that were not detected using the disproportionality analysis (DPA) methods.ConclusionsThe bagging-or-RF-based ML methods performed better than DPA and detected novel AE signals previously unidentified using the DPA methods. | Jang, Min-Gyo; Cha, SangHun; Kim, Seunghwak; Lee, Sojung; Lee, Kyeong Eun; Shin, Kwang-Hee | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Stat, Daegu, South Korea | 58125773600; 57638252600; 58126149100; 58126891900; 56041259000; 35216279300 | kshin@knu.ac.kr; | EXPERT OPINION ON DRUG SAFETY | EXPERT OPIN DRUG SAF | 1474-0338 | 1744-764X | 22 | 7 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 3 | 38.3 | 0.84 | 2025-06-25 | 2 | 3 | Disproportionality analysis; fluoroquinolones; signal detection; spontaneous reporting system; tree-based machine learning | DRUG-REACTIONS; ALGORITHMS | Disproportionality analysis; fluoroquinolones; signal detection; spontaneous reporting system; tree-based machine learning | Ciprofloxacin; Fluoroquinolones; Humans; Levofloxacin; Machine Learning; Republic of Korea; ciprofloxacin; gemifloxacin; levofloxacin; moxifloxacin; ofloxacin; ciprofloxacin; levofloxacin; quinolone derivative; adolescent; algorithm; area under the curve; Article; child; comparative study; controlled study; cross validation; decision tree; drug safety; feature detection; female; gastrointestinal disease; human; infant; Korea; machine learning; male; postmarketing surveillance; predictive value; random forest; respiratory tract disease; signal detection; skin disease; systematic review; machine learning; South Korea | English | 2023 | 2023-07-03 | 10.1080/14740338.2023.2181341 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Atypical lipomatous tumour/well-differentiated liposarcoma found in the buccal mucosa: A rare case report | Oral liposarcomas are uncommon diseases, the most predominant histopathological subtype being atypical lipomatous tumour/well-differentiated liposarcoma. In regard to its clinical aspects in the oral cavity, it is challenging to confirm a diagnosis and develop a treatment plan. In this case report, we present a rare case of atypical lipomatous tumour/well-differentiated liposarcoma in the right cheek of a 77-year-old male patient. Conservative surgery was performed considering the histopathological subtype of the neoplasm. Knowledge of the clinical and histopathological characteristics of this rare disease is essential to maintaining function and aesthetics through conservative treatment in older patients. © 2022 Gerodontology Association and John Wiley & Sons Ltd. | Lee, You-Jung; Choi, So-Young | Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, South Korea; Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu, South Korea | 57385615500; 57202918688 | dentalchoi@knu.ac.kr; | Gerodontology | GERODONTOLOGY | 0734-0664 | 1741-2358 | 40 | 1 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE;GERIATRICS & GERONTOLOGY | 2023 | 2 | 38.3 | 0 | 2025-06-25 | 0 | atypical lipomatous tumour/well-differentiated liposarcoma; conservative treatment, geriatric patient; histopathological subtype; oral liposarcoma | Aged; Diagnosis, Differential; Humans; Liposarcoma; Male; Mouth; Mouth Mucosa; aged; case report; differential diagnosis; human; liposarcoma; male; mouth; mouth mucosa; pathology | English | Final | 2023 | 10.1111/ger.12620 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Review | Caspase Cleavage of Receptor Tyrosine Kinases in the Dependence Receptor Family | Dependence receptors are a group of receptor proteins with shared characteristics of transducing two different signals within cells. They can transduce a positive signal of survival and differentiation in the presence of ligands. On the other hand, dependence receptors can transduce an apoptosis signal in the absence of ligands. The function of these receptors depends on the availability of their ligands. Several receptor tyrosine kinases (RTKs) have been reported as dependence receptors. When cells undergo apoptosis by dependence receptors, the intracellular domain of some RTKs is cleaved by the caspases. Among the RTKs that belong to dependence receptors, we focused on eight RTKs (RET, HER2, MET, ALK, TrkC, EphA4, EphB3, and c-KIT) that are cleaved by caspases. In this review, we describe the features of the receptors, their cleavage sites, and the fate of the cleaved products, as well as recent implications on them being used as potential therapeutics for cancer treatment. | Park, Gyu Hwan; Kang, Yoo Kyung; Paek, Seung-Mann; Shin, Chan Young; Han, Sun-Young | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Gyeongsang Natl Univ, Coll Pharm, Jinju 52828, South Korea; Gyeongsang Natl Univ, Res Inst Pharmaceut Sci, Jinju 52828, South Korea; Konkuk Univ, Sch Med, Dept Neurosci & Pharmacol, Seoul 05029, South Korea | Choi, Hayoung/AAI-8638-2020; Paek, Seung-Mann/B-2561-2008 | 9939639300; 57194053992; 35277744800; 15733168900; 55740196700 | syhan@gnu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 31 | 4 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 3 | 38.3 | 0.13 | 2025-06-25 | 1 | 2 | Dependence receptor; Cleavage; Receptor tyrosine kinase; Caspase | ANAPLASTIC LYMPHOMA KINASE; APOPTOSIS; TRKC; CANCERS; LIGAND; GROWTH; DOMAIN; ALPHA; FORMS; SITE | Caspase; Cleavage; Dependence receptor; Receptor tyrosine kinase | anaplastic lymphoma kinase; capmatinib; caspase; ephrin receptor A4; ephrin receptor B3; epidermal growth factor receptor 2; gamma urogastrone; lapatinib; neurotrophin 3 receptor; nucleophosmin; protein tyrosine kinase; stem cell factor receptor; tyrosine kinase receptor; acute myeloid leukemia; angiogenesis; apoptosis; carcinogenesis; cell aggregation; cell migration; gametogenesis; gene mutation; glioblastoma; human; mastocytosis; melanogenesis; morphogenesis; Review | English | 2023 | 2023-07 | 10.4062/biomolther.2022.133 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Functional Characterization of OsRac6 Involved in Pollen Germination in Rice | For a successful reproduction in angiosperms, pollen germination and pollen tube growth must proceed normally. The processes are regulated by transcriptional regulation and cellular activities, in which signaling proteins are the key. Ras homolog (Rho)-type GTPases (Rops), which are known as RACs, are a group of Rho small GTP-binding proteins which evolved in plants. However, the molecular mechanisms of the rice Rac family (OsRac) genes in pollen germination are not yet understood. In this investigation, the OsRac6 gene, which is only expressed only during the pollen development stage, was identified. A functional characterization of OsRac6 using gene-edited mutants exhibits male sterility due to the disruption of pollen germination. Then, to determine downstream candidate genes modulated by the OsRac6 genes during pollen development, we performed RNA-seq analysis by comparing osrac6-1 and wild-type (WT) anthers. Subsequently, we identified 652 genes with pollen-preferential expression which were upregulated compared with the WT, and 608 genes which were downregulated. Furthermore, gene ontology (GO) enrichment and MapMan analyses show that downregulated genes are closely associated with transcription, protein ubiquitination, proteolysis, cell wall modification, cell organization, cell cycle, and calcium regulation. The results of this study will help in elucidating the molecular mechanisms of pollen germination in rice mediated by OsRac6. | Lee, Su Kyoung; Hong, Woo-Jong; Kim, Eui-Jung; Moon, Sunok; Kim, Yu-Jin; Park, Soon-Ki; Jung, Ki-Hong | Kyung Hee Univ, Grad Sch Green Bio Sci, Yongin 17104, South Korea; Kyung Hee Univ, Crop Biotech Inst, Yongin 17104, South Korea; Seoul Natl Univ, Res Ctr Plant Plast, Seoul 08826, South Korea; Pusan Natl Univ, Life & Ind Convergence Res Inst, Dept Life Sci & Environm Biochem, Miryang 50463, South Korea; Kyungpook Natl Univ, Sch Appl Bio Sci, Daegu 41566, South Korea; Kyung Hee Univ, Dept Smart Farm Sci, Yongin 17104, South Korea | ; Jung, Ki/L-5570-2019; Kim, YuJin/NQE-8241-2025; Hong, Woo-Jong/HPF-0756-2023 | 57223132353; 57194418669; 57214231436; 7401616474; 57074286200; 8055974900; 56022522000 | psk@knu.ac.kr;khjung2010@khu.ac.kr; | JOURNAL OF PLANT BIOLOGY | J PLANT BIOL | 1226-9239 | 1867-0725 | 66 | 5 | SCIE | PLANT SCIENCES | 2023 | 2.2 | 38.3 | 0.55 | 2025-06-25 | 4 | 4 | Rice; Rho family GTPase; Pollen germination; Transcription analysis | PROTEINS; TARGET; ACTIN; GENE; EXPRESSION; INSIGHTS; KINASES; PATHWAY; GROWTH; GUIDE | Pollen germination; Rho family GTPase; Rice; Transcription analysis | English | 2023 | 2023-10 | 10.1007/s12374-023-09403-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | MS-5, a Naphthalene Derivative, Induces Apoptosis in Human Pancreatic Cancer BxPC-3 Cells by Modulating Reactive Oxygen Species | Pancreatic cancer is one of the most fatal cancers with a poor prognosis. Standard chemotherapies have proven largely ineffective because of their toxicity and the development of resistance. Therefore, there is an urgent need to develop novel therapies. In this study, we investigated the antitumor activity of MS-5, a naphthalene derivative, on BxPC-3, a human pancreatic cancer cell line. We observed that MS-5 was cytotoxic to BxPC-3 cells, as well as inhibited the growth of cells in a concentration-and time- dependent manner. Flow cytometry analysis revealed that the percentage of annexin V-positive cells increased after MS-5 treatment. We also observed cleavage of caspases and poly (ADP-ribose) polymerase, and downregulation of Bcl-xL protein. Flow cytometry analysis of intracellular levels of reactive oxygen species (ROS) and mitochondrial superoxide suggested that MS-5 induced the generation of mitochondrial superoxide while lowering the overall intracellular ROS levels. Thus, MS-5 may be potential candidate for pancreatic cancer treatment. | Giri, Suman; Park, Gyu Hwan; Choi, Joon-Seok; Ma, Eunsook; Chun, Kyung-Soo; Joo, Sang Hoon | Daegu Catholic Univ, Dept Pharm, Gyongsan 38430, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Keimyung Univ, Coll Pharm, Daegu 42601, South Korea | Joo, Sang/B-4116-2008 | 59790640800; 9939639300; 57203732561; 16053100300; 34876578600; 55550907200 | sjoo@cu.ac.kr;chunks@kmu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 31 | 1 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 3 | 38.3 | 0.16 | 2025-06-25 | 1 | 1 | Reactive oxygen species; Pancreatic cancer; Apoptosis | SUPEROXIDE; INHIBITION; PROMOTES | Apoptosis; Pancreatic cancer; Reactive oxygen species | adenosine diphosphate ribose; caspase; cell marker; cyclin A; cyclin dependent kinase 2; cyclin E; heme oxygenase 1; lipocortin 5; manganese superoxide dismutase; naphthalene derivative; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein bcl 2; protein bcl xl; protein p27; reactive oxygen metabolite; antineoplastic activity; apoptosis; apoptosis assay; Article; BxPC-3 cell line; cancer prognosis; cell cycle; cell growth; cell lysate; cell viability; clinical article; controlled study; cytotoxicity; down regulation; flow cytometry; human; human cell; MS-5 cell line; pancreas cancer; pancreatic cancer cell line; Western blotting; WST assay | English | 2023 | 2023 | 10.4062/biomolther.2022.127 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Skeletal structure of asymmetric mandibular prognathism and retrognathism | BackgroundThis study aimed to compare the skeletal structures between mandibular prognathism and retrognathism among patients with facial asymmetry.ResultsPatients who had mandibular asymmetry with retrognathism (Group A) in The Netherlands were compared with those with deviated mandibular prognathism (Group B) in Korea. All the data were obtained from 3D-reformatted cone-beam computed tomography images from each institute. The right and left condylar heads were located more posteriorly, inferiorly, and medially in Group B than in Group A. The deviated side of Group A and the contralateral side of Group B showed similar condylar width and height, ramus-proper height, and ramus height. Interestingly, there were no inter-group differences in the ramus-proper heights. Asymmetric mandibular body length was the most significantly correlated with chin asymmetry in retrognathic asymmetry patients whereas asymmetric elongation of condylar process was the most important factor for chin asymmetry in deviated mandibular prognathism.ConclusionConsidering the 3D positional difference of gonion and large individual variations of frontal ramal inclination, significant structural deformation in deviated mandibular prognathism need to be considered in asymmetric prognathism patients. Therefore, Individually planned surgical procedures that also correct the malpositioning of the mandibular ramus are recommended especially in patients with asymmetric prognathism. | Xi, Tong; Vinayahalingam, Shankeeth; Berge, Stefaan; Maal, Thomas; Kwon, Tae-Geon | Radboud Univ Nijmegen, Nijmegen Med Ctr, Dept Oral & Maxillofacial Surg, Geert Grootepl 10, NL-6525 GA Nijmegen, Netherlands; Radboud Univ Nijmegen, Nijmegen Med Ctr, 3D Imaging Lab, Geert Grootepl 10, NL-6525 GA Nijmegen, Netherlands; Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, 2177 Dalgubeol Daero, Daegu 41940, South Korea | Xi, Tong/P-6268-2015; Vinayahalingam, Shankeeth/AAB-4733-2021; Maal, Thomas/L-4497-2015 | 36708902400; 57209450660; 7006934966; 16550153300; 35205433300 | kwondk@knu.ac.kr; | MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY | MAX PLAST RECONSTR S | 2288-8101 | 2288-8586 | 45 | 1 | ESCI | DENTISTRY, ORAL SURGERY & MEDICINE | 2023 | 2 | 38.3 | 0 | 2025-06-25 | 1 | 0 | Asymmetry; Condyle; Ramus; Mandibular prognathism; Retrognathism | CLASS-III MALOCCLUSION; FACIAL ASYMMETRY; 3-DIMENSIONAL ANALYSIS; DEVIATION; DIMENSIONS; MORPHOLOGY; POSITION; CONDYLE | Asymmetry; Condyle; Mandibular prognathism; Ramus; Retrognathism | adolescent; adult; anterio posterior depth; Article; axial condyle rotation; bilateral landmark; cephalometry; chin height; condylar head; condylar height; condylar width; cone beam computed tomography; controlled study; coronoid process; correlation analysis; demography; digital imaging and communications in medicine; face asymmetry; facial midsagittal reference plane; female; Frankfurt plane; frontal condyle inclination; frontal ramal inclination; human; image analysis; left mandibular body; major clinical study; male; mandibular asymmetry; mandibular hyperplasia; mandibular plane angle; mandibular prognathism; maxillary horizontal position; middle aged; occlusion; orthognathic surgery; ramus height; Ramus length; ramus proper height; ramus sagittal plane; reliability; reproducibility; retrognathia; sagittal ramal inclination; sigmoid notch; sigmoid notch; skeletal structure; spatial orientation; three-dimensional imaging; transverse geometric center; tube voltage; vertical condylar height | English | 2023 | 2023-08-09 | 10.1186/s40902-023-00393-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Effect of Luteolin on the Modulation of Vascular Contractility via ROCK and CPI-17 Inactivation | In this investigation, we made a study of the efficacy of luteolin (a flavonoid found in plants such as vegetables, herbs and fruits) on vascular contractibility and to elucidate the mechanism underlying the relaxation. Isometric contractions of denuded muscles were stored and combined with western blot analysis which was conducted to assess the phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) and phosphorylation-dependent inhibitory protein for myosin phosphatase (CPI-17) and to examine the effect of luteolin on the RhoA/ROCK/CPI-17 pathway. Luteolin significantly alleviated phorbol ester-, fluoride-and thrombox-ane mimetic-elicited contractions regardless of endothelial nitric oxide synthesis, implying its direct effect on smooth muscle. It also significantly alleviated the fluoride-elicited elevation in pCPI-17 and pMYPT1 levels and phorbol 12,13-dibutyrate-elicited in-crease in pERK1/2 level, suggesting depression of ROCK and PKC/MEK activity and ensuing phosphorylation of MYPT1, CPI-17 and ERK1/2. Taken together, these results suggest that luteolin-elicited relaxation includes myosin phosphatase reactivation and calcium desensitization, which seems to be arbitrated by CPI-17 dephosphorylation via ROCK/PKC inhibition. | Yoon, Hyuk-Jun; Kang, Dae Hong; Jin, Fanxue; Bang, Joon Seok; Sohn, Uy Dong; Je, Hyun Dong | Daegu Catholic Univ, Coll Pharm, Dept Pharmacol, Gyongsan 38430, South Korea; Kyungpook Natl Univ, Dept Pharmacol, Sch Med, Daegu 41944, South Korea; Sookmyung Womens Univ, Coll Pharm, Seoul 04310, South Korea; Chung Ang Univ, Coll Pharm, Dept Pharmacol, Seoul 06974, South Korea | 57201590819; 58141523500; 12788216300; 36855449200; 57188573852; 57221755247 | hyundong@cu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 31 | 2 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 3 | 38.3 | 0.62 | 2025-06-25 | 3 | 4 | CPI-17; Fluoride; Luteolin; MYPT1; Phorbol ester; ROCK | LIGHT-CHAIN PHOSPHATASE; SMOOTH-MUSCLE; RHO-KINASE; CA2+ SENSITIZATION; TARGET SUBUNIT-1; MYOSIN; PHOSPHORYLATION; ACTIVATION; MYPT1; PROTEIN | CPI-17; Fluoride; Luteolin; MYPT1; Phorbol ester; ROCK | acetylcholine; calcium; endothelial nitric oxide synthase; enzyme; etomidate; fluoride; luteolin; myosin; myosin phosphatase; myosin phosphatase targeting subunit 1; phenylephrine; phorbol ester; phosphorylation dependent inhibitory protein for myosin phosphatase; protein kinase; Rho kinase; thromboxane; unclassified drug; animal experiment; animal tissue; Article; calcium desensitization; densitometry; dephosphorylation; desensitization; drug efficacy; enzyme activity; male; muscle isometric contraction; muscle relaxation; muscle tissue; nonhuman; protein expression; protein phosphorylation; rat; smooth muscle; thoracotomy; vascular contractility; Western blotting | English | 2023 | 2023-03 | 10.4062/biomolther.2022.087 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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