연구성과로 돌아가기
2020 연구성과 (174 / 270)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Effect of fermented oyster extract on growth promotion in Sprague-Dawley rats | Background: Oysters (Crassostrea gigas) are a popular marine product worldwide and have the advantage of nutritional benefits. This study aimed to investigate the effect of fermented oyster extract (FO) on growth promotion, including analysis of body size, bone microarchitecture, hematology and biochemistry in vivo. Methods: The amount of nutrients and gamma aminobutyric acid (GABA) were determined. Sprague-Dawley rats were randomly divided into four groups: the control group, FO 50 group (FO 50 mg/kg), and FO 100 group (FO 100 mg/kg) were administered orally once daily and the recombinant human growth hormone (rhGH) group (200 mu g/kg) was intraperitoneally injected once daily for 14 days. Results: Oral administration of FO 100 significantly increased body length and had no effect on organ damage or hematological profiles. However, administration of rhGH significantly induced hypertrophy of the liver, kidney and spleen along with a marked increase in body length. Tibia length and the growth plate were increased, and bone morphometric parameters were slightly improved by FO and rhGH administration. Serum analysis showed that the levels of GH and insulin like growth factor-1 (IGF-1) were slightly upregulated by FO administration. Nevertheless, the protein expression of hepatic IGF-1 was markedly increased by FO 100 and rhGH administration. Conclusions: FO have high content of GABA, and induced positive effects on body length, tibial length, growth-plate length and hepatic IGF-1 synthesis in SD rats with no toxicity or alterations of hematological profile. Therefore, these results suggest that GABA-enriched FO could be considered a potential alternative treatment for growth stimulation. (C) 2020 Korea Institute of Oriental Medicine. Publishing services by Elsevier B.V. | Lee, Hyesook; Hwang-Bo, Hyun; Ji, Seon Yeong; Kim, Min Yeong; Kim, So Young; Woo, Minji; Keum, Young-Sam; Noh, Jeong Sook; Park, Joung-Hyun; Lee, Bae-Jin; Kim, Gi-Young; Park, Eui Kyun; Chang, Young-Chae; Jeon, You-Jin; Choi, Yung Hyun | Dong Eui Univ, Antiaging Res Ctr, Busan, South Korea; Busan Innovat Inst Ind Sci & Technol Planning, Busan, South Korea; Dongguk Univ, Coll Pharm, Goyang, South Korea; Dongguk Univ, Integrated Res Inst Drug Dev, Goyang, South Korea; Tongmyong Univ, Dept Food Sci & Nutr, Busan, South Korea; Marine Bioproc Co Ltd, Ocean Fisheries & Biol Ctr, Busan, South Korea; Jeju Natl Univ, Dept Marine Life Sci, Jeju, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Pathol & Regenerat Med, Daegu, South Korea; Catholic Univ Daegu, Sch Med, Res Inst Biomed Engn, Daegu, South Korea; Catholic Univ Daegu, Sch Med, Dept Med, Daegu, South Korea | Kim, Kyoungmi/AEP-3965-2022; Kim, Kyoung-Sook/A-7768-2017; Kim, So-Young/JFS-7698-2023; Jeon, You-Jin/AAD-3452-2021 | 57192499270; 57194275375; 57196357007; 57196352735; 57190262437; 56645860400; 7006621910; 33067955700; 53871782200; 35620558000; 7403063801; 37071072400; 7501843107; 55782690600; 57211727369 | choiyh@deu.ac.kr; | INTEGRATIVE MEDICINE RESEARCH | INTEGR MED RES | 2213-4220 | 2213-4239 | 9 | 4 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE | 2020 | 2.379 | 55.4 | 0.85 | 2025-06-25 | 5 | 7 | Fermented oyster (FO); Recombinant human growth hormone (rhGH); Insulin like growth factor-1; Tibial growth plate; Gamma aminobutyric acid (GABA) | AROMATASE INHIBITORS; BONE; ACID | Fermented oyster (FO); Gamma aminobutyric acid (GABA); Insulin like growth factor-1; Recombinant human growth hormone (rhGH); Tibial growth plate | 4 aminobutyric acid; alanine aminotransferase; aspartate aminotransferase; calcium; creatinine; growth hormone; hemoglobin; human growth hormone; oyster extract; somatomedin binding protein 3; somatomedin C; alanine aminotransferase blood level; animal experiment; Article; aspartate aminotransferase blood level; blood analysis; blood biochemistry; body height; body size; body weight; bone microarchitecture; calcium blood level; controlled study; Crassostrea gigas; creatinine blood level; epiphysis plate; erythrocyte count; female; fermented product; growth hormone blood level; hematocrit; hemoglobin blood level; in vivo study; kidney hypertrophy; leukocyte count; liver hypertrophy; mean corpuscular hemoglobin; mean corpuscular volume; nonhuman; platelet count; protein expression; rat; splenomegaly; Sprague Dawley rat; upregulation; urea nitrogen blood level | English | 2020 | 2020-12 | 10.1016/j.imr.2020.100412 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Porcine deltacoronavirus activates the Raf/MEK/ERK pathway to promote its replication | Porcine deltacoronavirus (PDCoV) is a newly emerged swine coronavirus that causes acute enteritis in neonatal piglets. To date, little is known about the host factors or cellular signaling mechanisms associated with PDCoV replication. Since the Raf/MEK/ERK pathway is involved in modulation of various important cellular functions, numerous DNA and RNA viruses coopt this pathway for efficient propagation. In the present study, we found that PDCoV induces the activation of ERK1/2 and its downstream substrate Elk-1 early in infection irrespective of viral biosynthesis. Chemical inhibition or knockdown of ERK1/2 significantly suppressed viral replication, whereas treatment with an ERK activator increased viral yields. Direct pharmacological inhibition of ERK activation had no effect on the viral entry process but sequentially affected the post-entry steps of the virus life cycle. In addition, pharmacological sequestration of cellular or viral cholesterol downregulated PDCoV-induced ERK signaling, highlighting the significance of the cholesterol contents in ERK activation. However, ERK inhibition had no effect on PDCoV-triggered apoptosis through activation of the cytochrome c-mediated intrinsic mitochondrial pathway, suggesting the irrelevance of ERK activation to the apoptosis pathway during PDCoV infection. Altogether, our findings indicate that the ERK signaling pathway plays a pivotal role in viral biosynthesis to facilitate the optimal replication of PDCoV. | Jeon, Ji Hyun; Lee, Yoo Jin; Lee, Changhee | Kyungpook Natl Univ, Sch Life Sci, Anim Virol Lab, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Korea Brain Res Inst, Dept Neural Dev & Dis, Daegu 41068, South Korea | 57189574512; 59630220900; 55700560700 | changhee@knu.ac.kr; | VIRUS RESEARCH | VIRUS RES | 0168-1702 | 1872-7492 | 283 | SCIE | VIROLOGY | 2020 | 3.303 | 55.4 | 0.64 | 2025-06-25 | 15 | 16 | PDCoV; ERK1/2; Signal transduction; Cholesterol; Viral replication | VIRUS-REPLICATION; GENE-EXPRESSION; ERK ACTIVATION; CELL-DEATH; PROTEIN; IDENTIFICATION; INHIBITION; DIARRHEA; GENOME; PHOSPHORYLATION | Cholesterol; ERK1/2; PDCoV; Signal transduction; Viral replication | Active Transport, Cell Nucleus; Animals; Cell Nucleus; Cells, Cultured; Cholesterol; Coronavirus; Coronavirus Infections; ets-Domain Protein Elk-1; Host-Pathogen Interactions; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Signal Transduction; Swine; Virus Replication; 1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene; cholesterol; cytochrome c; mitogen activated protein kinase 1; mitogen activated protein kinase 3; transcription factor Elk 1; cholesterol; mitogen activated protein kinase 1; mitogen activated protein kinase 3; transcription factor Elk 1; animal cell; apoptosis; Article; cell nucleus; controlled study; Coronavirinae; Coronavirus infection; down regulation; enzyme activation; enzyme inhibition; enzyme phosphorylation; gene knockdown; MAPK signaling; mitochondrion; mouse; nonhuman; Porcine deltacoronavirus; priority journal; protein transport; virion; virus entry; virus replication; animal; cell culture; Coronavirinae; genetics; host pathogen interaction; metabolism; nucleocytoplasmic transport; phosphorylation; physiology; pig; signal transduction; virology | English | 2020 | 2020-07-02 | 10.1016/j.virusres.2020.197961 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Antiepileptic Drug Selection According to Seizure Type in Adult Patients with Epilepsy | Epilepsy is a common neurological disorder that is mainly treated using antiepileptic drugs. Several antiepileptic drugs such as phenobarbital, phenytoin, primidone, and ethosuximide were developed in the early 20th century. More than 10 types of antiepileptic drugs have been developed since the 1990s, and there are now more than 20 antiepileptic drugs in active clinical use. The choice of antiepileptic drugs is based on the clinical features of the seizure types, electroencephalogram findings, epileptic syndrome, and drug stability. Currently there are 19 antiepileptic drugs approved by the Korean Food and Drug Administration, 18 of which (with the exclusion of brivaracetam) are covered by the National Health Insurance Service in Korea. We reviewed the selection of antiepileptic drugs according to the classification of epileptic seizures. | Kim, Hyeyun; Kim, Dong Wook; Lee, Soon Tae; Byun, Jung Ick; Seo, Jong Geun; No, Young Joo; Kang, Kyung Wook; Kim, Daeyoung; Kim, Keun Tae; Cho, Yong Won; Yang, Kwang Ik | Catholic Kwandong Univ, Dept Neurol, Coll Med, Int St Marys Hosp, Incheon, South Korea; Konkuk Univ, Dept Neurol, Sch Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Neurol, Seoul, South Korea; Kyunghee Univ Hosp Gangdong, Dept Neurol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Samsung Noble Cty, Dept Neurol, Yongin, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Neurol, Sch Med, Gwangju, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Neurol, Sch Med, Daejeon, South Korea; Keimyung Univ, Sch Med, Dept Neurol, 1095 Dalgubeol Daero, Daegu 42601, South Korea; Soonchunhyang Univ, Cheonan Hosp, Dept Neurol, Coll Med, Cheonan, South Korea | ; Kim, Keun Tae/IQU-1105-2023; Lee, Soon-Tae/C-4663-2013 | 57199073222; 57075285300; 8527655300; 55896913500; 16040307500; 6701791454; 57211333312; 57191361218; 57204465615; 55080335000; 55328263200 | neurocho@gmail.com;neurofan@schmc.ac.kr; | JOURNAL OF CLINICAL NEUROLOGY | J CLIN NEUROL | 1738-6586 | 2005-5013 | 16 | 4 | SCIE | CLINICAL NEUROLOGY | 2020 | 3.077 | 55.5 | 0.57 | 2025-06-25 | 20 | 22 | antiepileptics; seizure; epilepsy; adults | ADD-ON THERAPY; IDIOPATHIC GENERALIZED EPILEPSY; LENNOX-GASTAUT SYNDROME; OPEN-LABEL; DOUBLE-BLIND; MYOCLONIC EPILEPSY; FOCAL SEIZURES; VALPROIC ACID; LEVETIRACETAM; LAMOTRIGINE | Adults; Antiepileptics; Epilepsy; Seizure | anticonvulsive agent; benzodiazepine; brivaracetam; carbamazepine; clobazam; eslicarbazepine acetate; ethosuximide; felbamate; gabapentin; lacosamide; lamotrigine; levetiracetam; oxcarbazepine; perampanel; phenobarbital; phenytoin; pregabalin; primidone; tiagabine; topiramate; valproic acid; vigabatrin; zonisamide; anticonvulsant activity; augmentation index; awareness; bioavailability; consciousness; drug absorption; drug efficacy; drug metabolism; drug safety; drug stability; electroencephalography; epilepsy; focal epilepsy; Food and Drug Administration; human; Lennox Gastaut syndrome; liver cell carcinoma; long QT syndrome; mental disease; monotherapy; neurologic disease; pharmacodynamic parameters; pregnancy; prescription; protein binding; Review; seizure | English | 2020 | 2020-10 | 10.3988/jcn.2020.16.4.547 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Cefepime-Induced Encephalopathy in a Tertiary Medical Center in Korea | Background and Purpose Cefepime is a widely used fourth-generation cephalosporin. It is commonly used as a first-line antibiotic to treat various infectious diseases such as hospital-acquired pneumonia, urinary tract infections, and bacterial meningitis. The primary outcome of this study was the development of cefepime-induced encephalopathy (CIE) at a tertiary medical center in Korea. We also aimed to describe the clinical features of CIE. Methods We enrolled 1,793 consecutive patients treated with cefepime. The CIE group included 44 patients who experienced altered consciousness after receiving cefepime without any other obvious cause and showed full recovery after stopping cefepime. This study collected demographic data, laboratory findings, and clinical data including the cause of infection, duration for onset of altered consciousness, duration of cefepime treatment, dosage of cefepime, duration of recovering consciousness after stopping cefepime, sequelae after encephalopathy, and electroencephalography data. Results Forty-four (2.5%) patients were included in the CIE group. The age was significantly higher in the CIE group than in the control group (71.2 +/- 10.8 years vs. 64.7 +/- 16.1 years, mean +/- standard deviation; p=0.007), and females constituted a significantly large proportion in the CIE group (27 of 44, 61.4%). The CIE group had higher blood urea nitrogen (34.7 +/- 22.6 mg/dL vs. 23.0 +/- 17.5 mg/dL, p<0.001) and creatinine (2.2 +/- 2.5 mg/dL vs. 1.1 +/- 1.3 mg/dL, p<0.001), and lower estimated glomerular filtration rate (eGFR) (56.3 +/- 46.0 mL/min/1.73 mm(2) vs. 98.8 +/- 66.3 mL/min/1.73 mm(2), p<0.001). Multivariate analysis showed that only eGFR was significantly related to CIE. Conclusions The incidence of CIE was 2.5% in this study. It is essential to consider the possibility of CIE occurring, especially in patients with lower values of eGFR and dialysis. | Jeon, Ji-Ye; Cho, Yong Won; Moon, Hye-Jin | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurol, Sch Med, Daegu, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Neurol, Coll Med, 170 Jomaru Ro, Bucheon 14584, South Korea | 57194943660; 55080335000; 55201533100 | moonhyejin21@gmail.com; | JOURNAL OF CLINICAL NEUROLOGY | J CLIN NEUROL | 1738-6586 | 2005-5013 | 16 | 3 | SCIE | CLINICAL NEUROLOGY | 2020 | 3.077 | 55.5 | 0.08 | 2025-06-25 | 6 | 5 | encephalopathy; cefepime; epilepsy; incidence; electroencephalography | PATIENT | Cefepime; Electroencephalography; Epilepsy; Incidence; Encephalopathy | albumin; bilirubin; C reactive protein; cefepime; ceftriaxone; clindamycin; creatinine; levetiracetam; lorazepam; adult; aged; aphasia; Article; brain disease; case report; cefepime induced encephalopathy; chronic kidney failure; clinical article; comatose patient; confusion; consciousness; controlled study; creatinine clearance; diabetes mellitus; drowsiness; drug substitution; drug withdrawal; dyspnea; electroencephalography; epileptic state; estimated glomerular filtration rate; female; follow up; Glasgow coma scale; glucose blood level; heart palpitation; hospital admission; human; hypertension; Korea; major clinical study; male; mental health; multivariate analysis; peritoneal dialysis; platelet count; psychosis; Rankin scale; respiratory tract infection; risk factor; seizure; stupor; tertiary health care; urea nitrogen blood level; urinary tract infection | English | 2020 | 2020-07 | 10.3988/jcn.2020.16.3.408 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Clinical Approach to Autoimmune Epilepsy | Autoimmune epilepsy is a newly emerging area of epilepsy. The concept of "autoimmune" as an etiology has recently been revisited thanks to advances in autoimmune encephalitis and precision medicine with immunotherapies. Autoimmune epilepsy presents with specific clinical manifestations, and various diagnostic approaches including cerebrospinal fluid analysis, neuroimaging, and autoantibody tests are essential for its differential diagnosis. The diagnosis is often indeterminate despite performing a thorough evaluation, and therefore empirical immunotherapy may be applied according to the judgment of the clinician. Autoimmune epilepsy often manifests as new-onset refractory status epilepticus (NORSE). A patient classified as NORSE should receive empirical immunotherapy as soon as possible. On the other hand, a more cautious, stepwise approach is recommended for autoimmune epilepsy that presents with episodic events. The type of autoimmune epilepsy is also an important factor to consider when choosing from among various immunotherapy options. Clinicians should additionally take the characteristics of antiepileptic drugs into account when using them as an adjuvant therapy. This expert opinion discusses the diagnostic and treatment approaches for autoimmune epilepsy from a practical point of view. | Jang, Yoonhyuk; Kim, Dong Wook; Yang, Kwang Ik; Byun, Jung-Ick; Seo, Jong-Geun; No, Young Joo; Kang, Kyung Wook; Kim, Daeyoung; Kim, Keun Tae; Cho, Yong Won; Lee, Soon-Tae | Seoul Natl Univ Hosp, Dept Neurol, 101 Daehak Ro, Seoul 03080, South Korea; Konkuk Univ, Sch Med, Dept Neurol, Seoul, South Korea; Soonchunhyang Univ, Cheonan Hosp, Coll Med, Dept Neurol, Cheonan, South Korea; Kyunghee Univ Hosp Gangdong, Dept Neurol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Samsung Noble Cty, Dept Neurol, Yongin, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Neurol, Sch Med, Gwangju, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Neurol, Sch Med, Daejeon, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurol, 1095 Dalgubeol Daero, Daegu 42601, South Korea | ; Lee, Sang/J-5578-2012; Jang, Yoonhyuk/AAY-2940-2021; Kim, Keun Tae/IQU-1105-2023 | 57193923303; 57075285300; 55328263200; 55896913500; 16040307500; 6701791454; 57211333312; 57191361218; 57204465615; 55080335000; 8527655300 | neurocho@gmail.com;staelee@snu.ac.kr; | JOURNAL OF CLINICAL NEUROLOGY | J CLIN NEUROL | 1738-6586 | 2005-5013 | 16 | 4 | SCIE | CLINICAL NEUROLOGY | 2020 | 3.077 | 55.5 | 0.61 | 2025-06-25 | 17 | 18 | autoimmune epilepsy; autoimmune encephalitis; NORSE; autoimmune epilepsy treatment; autoimmune epilepsy immunotherapy; refractory status epilepticus | FACIOBRACHIAL DYSTONIC SEIZURES; NMDA RECEPTOR ENCEPHALITIS; MYCOPHENOLATE-MOFETIL; LIMBIC ENCEPHALITIS; RITUXIMAB; IMMUNOTHERAPY; TOCILIZUMAB; MECHANISMS; ANTIBODIES; DIAGNOSIS | Autoimmune encephalitis; Autoimmune epilepsy; Autoimmune epilepsy immunotherapy; Autoimmune epilepsy treatment; NORSE; Refractory status epilepticus | autoantibody; azathioprine; bortezomib; corticosteroid; cyclophosphamide; cytochrome P450 2C9; dexamethasone; interleukin 17; lacosamide; lamotrigine; methotrexate; methylprednisolone; mycophenolate mofetil; rituximab; tocilizumab; adjuvant chemotherapy; bipolar disorder; brain biopsy; cellular immunity; cerebrospinal fluid; cerebrospinal fluid analysis; computer assisted tomography; cortical dysplasia; cytopenia; decision making; demyelinating disease; differential diagnosis; disease duration; disease severity; electroencephalography; epilepsy; hippocampus; immunosuppressive treatment; immunotherapy; medical decision making; Mini Mental State Examination; multiple myeloma; neuroimaging; neurologic examination; nuclear magnetic resonance imaging; pathogenesis; personalized medicine; plasma exchange; positron emission tomography; rash; Review; treatment response | English | 2020 | 2020-10 | 10.3988/jcn.2020.16.4.519 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Eye Movements and Vestibulo-Ocular Reflex in Periventricular Leukomalacia | Kim, Sung-Hee; Kim, Ji-Soo | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, 807 Hoguk Ro, Daegu 41404, South Korea; Seoul Natl Univ, Coll Med, Dept Neurol, Bundang Hosp, Seoul, South Korea | Kim, Ji-Soo/D-8744-2012 | 55718655600; 8055087900 | sefirot36@naver.com; | JOURNAL OF CLINICAL NEUROLOGY | J CLIN NEUROL | 1738-6586 | 2005-5013 | 16 | 1 | SCIE | CLINICAL NEUROLOGY | 2020 | 3.077 | 55.5 | 0 | 2025-06-25 | 0 | 0 | VISUAL IMPAIRMENT; CHILDREN | adult; Bell palsy; case report; clinical article; encephalomalacia; eye movement; female; gestational age; heart left ventricle hypertrophy; human; learning disorder; Letter; nuclear magnetic resonance imaging; ophthalmoscopy; placenta previa; strabismus; vestibuloocular reflex; visual acuity | English | 2020 | 2020-01 | 10.3988/jcn.2020.16.1.172 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Gate Architecture Effects on the Gate Leakage Characteristics of GaN Wrap-gate Nanowire Transistors | Gate leakage current in lateral GaN wrap-gate nanowire transistors (WG-NWT) was investigated using current density-voltage (J(g)-V-g) characteristics at room temperature. We found that the gate leakage current is strongly dependent on the top corner angle of the gate architecture. This leakage current was characterized by considering hopping (Poole-Frenkel emission) and trap-assisted thermionic emission mechanisms. Despite its smaller gate area, the gate leakage current of the lateral GaN WG-NWT without a 2DEG channel was higher than that of the device with a 2DEG channel for all applied gate biases. The reason for this is that the lateral GaN WG-NWT without 2DEG channel has a triangular cross-section with a sharp top corner angle resulting in a strong electric field due to geometrical field enhancement. | Mallem, Siva Pratap Reddy; Im, Ki-Sik; Thingujam, Terirama; Lee, Jung-Hee; Caulmilone, Raphael; Cristoloveanu, Sorin | Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Kumoh Natl Inst Technol, Adv Mat Res Ctr, Gumi 39177, South Korea; SOITEC, F-38190 Bernin, France; Minatec, Grenoble Polytech Inst, Inst Microelect Electromagnetism & Photon, F-38016 Grenoble, France | 55422639100; 8679677600; 57194828103; 57196140713; 57190580569; 15076615300 | ksim3492@gmail.com;jlee@ee.knu.ac.kr; | ELECTRONIC MATERIALS LETTERS | ELECTRON MATER LETT | 1738-8090 | 2093-6788 | 16 | 5 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 3.017 | 55.5 | 0.16 | 2025-06-25 | 2 | 2 | GaNOI; Nanowire; Wrap-gate transistor; Triangular; trapezoidal architectures; Corner angle | ALGAN/GAN | Corner angle; GaNOI; Nanowire; Triangular/trapezoidal architectures; Wrap-gate transistor | Electric fields; Gallium nitride; III-V semiconductors; Nanowires; Thermionic emission; Corner angle; Gate bias; Gate leakages; Gate-leakage current; Geometrical field enhancement; Nanowire transistors; Strong electric fields; Triangular cross-sections; Leakage currents | English | 2020 | 2020-09 | 10.1007/s13391-020-00229-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Intercorrelated Relationship Between the Thermoelectric Performance and Mechanical Reliability of Mg2Si-Reduced Graphene Oxide Nanocomposites | We fabricated Mg2Si-based thermoelectric nanocomposites with reduced graphene oxide using ultrasonic-based wet chemical pulverizing-mixing and spark plasma sintering to improve the trade-off relationship between thermoelectric properties and mechanical reliability. The dependence of thermoelectric properties and mechanical reliability on the nanophase morphologies has been systemically investigated, demonstrating the fracture toughness of the nanocomposite with thin reduced graphene oxide significantly increased. Moreover, the introduction of the few-layered reduced graphene oxide with high interface density was more effective in improving the trade-off relationship. This result suggests that an in-depth research on the dependence of the thermoelectric properties and mechanical reliability on the intrinsic properties of the nanophases is required to prepare efficient thermoelectric nanocomposites. Graphic | Kim, Gwansik; Kim, Wonkyung; Lee, Wooyoung | Yonsei Univ, Dept Mat Sci, Engn, Seoul, South Korea; Kyungpook Natl Univ, Sch Nano, Mat Sci, Engn, 2559 Gyeongsang-daero, Daegu, Daegu Gwang'yeo, South Korea | 57143208300; 55492072500; 55498383000 | happ20@daum.net;wooyoung@yonsei.ac.kr; | ELECTRONIC MATERIALS LETTERS | ELECTRON MATER LETT | 1738-8090 | 2093-6788 | 16 | 2 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 3.017 | 55.5 | 0.31 | 2025-06-25 | 4 | 6 | Thermoelectric; Mg2Si; Fracture toughness; Trade-off relationship | MG2SI; SKUTTERUDITE; TOUGHNESS; AL; BI | Fracture toughness; Mg<sub>2</sub>Si; Thermoelectric; Trade-off relationship | Economic and social effects; Fracture toughness; Graphene; Nanocomposites; Reliability; Spark plasma sintering; Thermoelectric equipment; Mechanical reliability; Mg2Si; Nanophase morphology; Reduced graphene oxides; Thermoelectric; Thermoelectric performance; Thermoelectric properties; Trade-off relationship; Thermoelectricity | English | 2020 | 2020-03 | 10.1007/s13391-019-00193-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Pharmacological Treatment of Epilepsy in Elderly Patients | The incidence and prevalence of epilepsy are highest in elderly people, and the etiologies of epilepsy in the elderly differ from those in other age groups. Moreover, diagnosing and treating epilepsy in elderly people may be challenging due to differences in clinical characteristics and physiological changes associated with aging. This review focuses on the pharmacological treatment of epilepsy in elderly patients. | Seo, Jong-Geun; Cho, Yong Won; Kim, Keun Tae; Kim, Dong Wook; Yang, Kwang Ik; Lee, Soon-Tae; Byun, Jung-Ick; No, Young Joo; Kang, Kyung Wook; Kim, Daeyoung | Kyungpook Natl Univ, Sch Med, Dept Neurol, 680 Gukchaebosang Ro, Daegu 42911, South Korea; Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Neurol, Daegu, South Korea; Konkuk Univ, Sch Med, Dept Neurol, Seoul, South Korea; Soonchunhyang Univ, Cheonan Hosp, Coll Med, Dept Neurol, Cheonan, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Neurol, Seoul, South Korea; Kyung Hee Univ Hosp Gangdong, Dept Neurol, Seoul, South Korea; Samsung Noble Cty, Dept Neurol, Yongin, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Sch Med, Dept Neurol, Gwangju, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Sch Med, Dept Neurol, Daejeon, South Korea | ; Kim, Keun Tae/IQU-1105-2023; Lee, Soon-Tae/C-4663-2013 | 16040307500; 55080335000; 57204465615; 57075285300; 55328263200; 8527655300; 55896913500; 6701791454; 57211333312; 57191361218 | jonggeun.seo@gmail.com;neurocho@gmail.com; | JOURNAL OF CLINICAL NEUROLOGY | J CLIN NEUROL | 1738-6586 | 2005-5013 | 16 | 4 | SCIE | CLINICAL NEUROLOGY | 2020 | 3.077 | 55.5 | 0.44 | 2025-06-25 | 15 | 17 | epilepsy; elderly; treatment | NEW-ONSET EPILEPSY; NEWLY-DIAGNOSED EPILEPSY; ANTIEPILEPTIC DRUG; RISK-FACTORS; DOUBLE-BLIND; OPTIMIZING THERAPY; SEIZURES; LEVETIRACETAM; CARBAMAZEPINE; LAMOTRIGINE | Elderly; Treatment; epilepsy | alkaline phosphatase; antidepressant agent; carbamazepine; creatinine; furosemide; gabapentin; hydroxymethylglutaryl coenzyme A reductase inhibitor; lamotrigine; levetiracetam; oxcarbazepine; phenobarbital; phenytoin; pregabalin; tolvaptan; topiramate; trihexyphenidyl; valproic acid; zonisamide; aged; Alzheimer disease; astrocytoma; atrioventricular conduction; bone density; brain hemorrhage; brain infarction; cerebrovascular disease; cognitive defect; creatinine clearance; dementia; diplopia; drug efficacy; drug tolerability; electroencephalography; epilepsy; head injury; human; hypertension; hyponatremia; incidence; liver toxicity; meningioma; neuroimaging; prescription; prevalence; Review; risk factor; seizure; somnolence; tonic clonic seizure; urolithiasis | English | 2020 | 2020-10 | 10.3988/jcn.2020.16.4.556 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Real-Life Effectiveness and Tolerability of Perampanel in Pediatric Patients Aged 4 Years or Older with Epilepsy: A Korean National Multicenter Study | Background and Purpose The US Food and Drug Administration approval for perampanel has only recently been expanded to patients as young as 4 years, and so there have been few real-life studies of the effects of perampanel in pediatric patients. The aim of this study was to determine the long-term efficacy, factors affecting treatment response, and tolerability of perampanel as an add-on therapy in pediatric patients aged 4 years or epilepsy. Methods This multicenter retrospective observational study collected data from pediatric epilepsy centers of four Korean national universities. Changes in the seizure frequency from baseline, adverse events, and retention rates were obtained at 3, 6, and 12 months. Adverse events and discontinuation profiles were obtained to assess tolerability. Results This study included 220 children and adolescents (117 males and 103 females) aged 4 to 20 years. The overall response rate was 43.6%, and the seizure-freedom rate was 17.7%. Factors affecting a good treatment response were the absence of intellectual disability, small number of concomitant antiepileptic drugs, and low baseline seizure frequency. Eighty-eight patients (40%) experienced adverse events, but they mostly were of mild severity and resolved after the dose reduction or discontinuation of perampanel. The retention rates at 3, 6, and 12 months were 85.0%, 71.8%, and 50.5%, respectively. Conclusions Adjunctive treatment with perampanel was efficacious and tolerated in pediatric patients aged 4 years or older with epilepsy. Early perampanel treatment may help to reduce the burden of their seizures and improve their quality of life. | Hwang, Su-Kyeong; Lee, Yun-Jin; Nam, Sang Ook; Kim, Won Seop; Kim, Jon Soo; Kim, Sun Jun; Lee, Yun-Jeong; Kwon, Soonhak | Kyungpook Natl Univ, Sch Med, Dept Pediat, 807 Hoguk Ro, Daegu 41404, South Korea; Pusan Natl Univ, Childrens Hosp, Sch Med, Dept Pediat, Yangsan, South Korea; Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea; Chungbuk Natl Univ, Coll Med, Dept Pediat, Cheongju, South Korea; Chonbuk Natl Univ, Med Sch, Dept Pediat, Jeonju, South Korea | ; KIM, JOO YEOL/HRC-8018-2023; Kim, Sae/AAR-3907-2020; Kim, Siwon/KHX-9078-2024 | 37761570400; 55786639400; 36461383000; 36677553400; 55425902600; 57193955312; 55978748900; 55468232200 | shkwon@knu.ac.kr; | JOURNAL OF CLINICAL NEUROLOGY | J CLIN NEUROL | 1738-6586 | 2005-5013 | 16 | 1 | SCIE | CLINICAL NEUROLOGY | 2020 | 3.077 | 55.5 | 1.22 | 2025-06-25 | 31 | 28 | perampanel; children; treatment efficacy; adverse drug reactions | ADJUNCTIVE PERAMPANEL; REFRACTORY EPILEPSIES; ADOLESCENTS; CHILDREN; AMPA; EFFICACY; FOCUS; SEIZURES | Adverse drug reactions; Children; Treatment efficacy; Perampanel | anticonvulsive agent; perampanel; add on therapy; adolescent; adult; alpha thalassemia-mental retardation syndrome X-linked; anger; appetite disorder; Article; ataxia; bipolar disorder; child; clinical effectiveness; comparative study; controlled study; depression; dizziness; drug dose increase; drug dose reduction; drug tolerability; drug withdrawal; epilepsy; female; focal epilepsy; generalized epilepsy; genetic heterogeneity; headache; human; infection; insomnia; intellectual impairment; ketogenic diet; long term care; major clinical study; male; mild cognitive impairment; multicenter study; nausea and vomiting; observational study; pediatric patient; preschool child; quality of life assessment; recurrent disease; retrospective study; school child; somnolence; suicide attempt; survival analysis; treatment response time; vagus nerve stimulation; violence; wrist injury; young adult | English | 2020 | 2020-01 | 10.3988/jcn.2020.16.1.53 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Refining General Principles of Antiepileptic Drug Treatments for Epilepsy | Antiepileptic drugs (AEDs) are the primary treatment strategy for epilepsy. As the use of AEDs has become more widespread and diverse over the past century, it has become necessary to refine the associated prescription strategies. This prompted the Drug Committee of the Korean Epilepsy Society to perform a systemic review of both international and domestic guidelines as well as literature related to medical treatment of epilepsy, and prepared a series of reviews to provide practical guidelines for clinicians to follow. This article is the first in a series on AED treatments for epilepsy in South Korea. | Kim, Keun Tae; Kim, Dong Wook; Yang, Kwang Ik; Lee, Soon-Tae; Byun, Jung-Ick; Seo, Jong-Geun; No, Young Joo; Kang, Kyung Wook; Kim, Daeyoung; Cho, Yong Won | Keimyung Univ, Dept Neurol, Sch Med, 1095 Dalgubeol Daero, Daegu 42601, South Korea; Konkuk Univ, Dept Neurol, Sch Med, Seoul, South Korea; Soonchunhyang Univ, Cheonan Hosp, Dept Neurol, Coll Med, Cheonan, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Kyunghee Univ Hosp Gangdong, Dept Neurol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Samsung Noble Cty, Dept Neurol, Yongin, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Neurol, Sch Med, Gwangju, South Korea; Chungnam Natl Univ, Sch Med, Chungnam Natl Univ Hosp, Dept Neurol, Daejeon, South Korea | Kim, Keun Tae/IQU-1105-2023; Lee, Soon-Tae/C-4663-2013 | 57204465615; 57075285300; 55328263200; 8527655300; 55896913500; 16040307500; 6701791454; 57211333312; 57191361218; 55080335000 | neurocho@gmail.com; | JOURNAL OF CLINICAL NEUROLOGY | J CLIN NEUROL | 1738-6586 | 2005-5013 | 16 | 3 | SCIE | CLINICAL NEUROLOGY | 2020 | 3.077 | 55.5 | 0.26 | 2025-06-25 | 10 | 12 | epilepsy; antiepileptic drugs; anticonvulsants; therapeutics | WELL-CONTROLLED EPILEPSY; SEIZURE-FREE PATIENTS; STATUS EPILEPTICUS; ILAE COMMISSION; RISK; DEFINITION; RECURRENCE; MANAGEMENT; CLASSIFICATION; IMMEDIATE | Anticonvulsants; Antiepileptic drugs; Therapeutics; epilepsy | anticonvulsive agent; carbamazepine; ethosuximide; gabapentin; HLA B antigen; lacosamide; lamotrigine; levetiracetam; lorazepam; oxcarbazepine; perampanel; phenobarbital; phenytoin; pregabalin; topiramate; valproic acid; vigabatrin; zonisamide; agranulocytosis; alopecia; anemia; anorexia; aplastic anemia; arthralgia; aseptic meningitis; ataxia; balance impairment; behavior disorder; bone density; cerebellum atrophy; clinician; cognitive defect; depression; diplopia; dizziness; drug dose; drug efficacy; drug tolerability; edema; electroencephalogram; epilepsy; epileptic state; focal epilepsy; gastrointestinal disease; gingiva hypertrophy; headache; heart arrhythmia; human; hyperammonemia; hypertransaminasemia; hyponatremia; lethargy; leukopenia; liver dysfunction; lymphadenopathy; mood disorder; myoclonus epilepsy; neurologic examination; nystagmus; obesity; osteoporosis; pancytopenia; pharmacokinetic parameters; practice guideline; prescription; psychosis; quality of life; rash; Review; seizure; somnolence; Stevens Johnson syndrome; systematic review; thrombocytopenia; tonic clonic seizure; tremor; wasting syndrome; xerostomia | English | 2020 | 2020-07 | 10.3988/jcn.2020.16.3.383 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Reliability and Validity of the Korean Version of the Spinal and Bulbar Muscular Atrophy Functional Rating Scale | Background and Purpose The Spinal and Bulbar Muscular Atrophy Functional Rating Scale (SBMAFRS) is a reliable and valid instrument for evaluating the functional status of patients with spinal and bulbar muscular atrophy (SBMA). This study aimed to validate a Korean version of the SBMAFRS in an SBMA population. Methods We applied the SBMAFRS to 64 SBMA patients at their regular follow-up clinical visits. The patients underwent clinical evaluations that included the 6-minute walking test (6MWT), forced vital capacity (FVC), manual muscle test, and the Penetration-Aspiration Scale (PAS). To estimate the stability of the SBMAFRS, the scale was reapplied to a subset of 31 randomly selected patients within 4 weeks of the initial test. The convergent validity was evaluated, and correlations were examined between SBMAFRS items and the muscular force, the total and subscores on the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R), FVC, PAS score, age at onset, disease duration, and 6MWT results. Results The internal consistency of the scale was confirmed by a high Cronbach's alpha (total raw alpha=0.867, total standardized alpha=0.863). The test-retest reliability as assessed by Spearman's rho was also high. The total score and subscores of the SBMAFRS were strongly correlated with the respective items and subscores of the ALSFRS-R, respiratory function, and the 6MWT. Conclusions We have performed a validation study of the Korean version of a disease-specific functional rating scale for SBMA patients. The SBMAFRS is a useful tool for clinical practice and as a potential outcome measure for Korean SBMA patients. | Oh, Seong-il; Oh, Juyeon; Park, Donghwi; Son, Kwangjoo; Park, Jin-Sung | Inje Univ, Busan Paik Hosp, Dept Neurol, Coll Med, Busan, South Korea; Dankook Univ, Coll Nursing, Cheonan, South Korea; Ulsan Univ Hosp, Dept Phys Med & Rehabil, Ulsan, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, 807 Hoguk Ro, Daegu 41404, South Korea | Park, Donghwi/GYQ-6185-2022; Oh, Seong-il/A-8790-2019 | 47861459800; 56623729800; 56606561400; 57219471938; 44061744500 | neurojspark@gmail.com; | JOURNAL OF CLINICAL NEUROLOGY | J CLIN NEUROL | 1738-6586 | 2005-5013 | 16 | 4 | SCIE | CLINICAL NEUROLOGY | 2020 | 3.077 | 55.5 | 0 | 2025-06-25 | 3 | 3 | spinal and bulbar muscular atrophy; translations; validity and reliability | CAG REPEAT; DISEASE; EXPANSION; SBMA | Translations; Validity and reliability; spinal and bulbar muscular atrophy | creatine kinase; adult; aged; Amyotrophic Lateral Sclerosis Functional Rating Scale; Article; CAG repeat; controlled study; Cronbach alpha coefficient; demography; disease duration; English (language); follow up; forced vital capacity; human; internal consistency; Kennedy disease; language; lower limb; lung function; major clinical study; male; manual muscle test; Medical Research Council Sum Score; middle aged; motor performance; muscle examination; muscle strength; onset age; Penetration Aspiration Scale; rating scale; reliability; respiratory function; six minute walk test; spinal and bulbar muscular atrophy functional rating scale; swallowing; test retest reliability; trunk; upper limb; validation study; validity; walking | English | 2020 | 2020-10 | 10.3988/jcn.2020.16.4.586 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Spontaneous Intracerebral Hemorrhage in a Patient with Asymptomatic 2019 Novel Coronavirus Disease | Kim, Changho; Kwak, Youngseok; Hwang, Jaechun; Eun, Mi-Yeon | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Emergency Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea | Eun, Mi-Yeon/AAV-2877-2021 | 56441824200; 58253867800; 54980345300; 36463396500 | eunmiyn@gmail.com; | JOURNAL OF CLINICAL NEUROLOGY | J CLIN NEUROL | 1738-6586 | 2005-5013 | 16 | 3 | SCIE | CLINICAL NEUROLOGY | 2020 | 3.077 | 55.5 | 1.1 | 2025-06-25 | 7 | 7 | ACE2; COVID-19 | analgesic agent; anticonvulsive agent; azithromycin; dexamethasone; hydroxychloroquine; adult; asymptomatic infection; brain edema; brain hemorrhage; case report; clinical article; computer assisted tomography; coronavirus disease 2019; drowsiness; female; headache; hemiparesis; human; Letter; middle aged; quarantine; real time reverse transcription polymerase chain reaction; throat culture; vasculitis | English | 2020 | 2020-07 | 10.3988/jcn.2020.16.3.515 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A Prospective Study for Prediction of Psychotic Relapse Using the Korean Early Signs Scale in Patients With Schizophrenia | Introduction A psychotic relapse of schizophrenia is commonly preceded by nonpsychotic behavioral symptoms and signs, and detection of these early signs may enable prevention of relapse of schizophrenia. This study aimed to test the predictive validity of a Korean version of Early Signs Scale (K-ESS) for psychotic relapse for detecting the early signs. Materials and Methods In this multicenter noninterventional 52-week prospective study, outpatients diagnosed as having schizophrenia within 5 years were recruited. The K-ESS and Clinical Global Impression-Severity (CGI-S) scale were administered monthly until the end of the study or the relapse. The primary objective was to determine an optimal cutoff point of K-ESS score for prediction of psychotic relapse. The secondary objective was to assess the concurrent validity of the K-ESS using CGI-S scale. Results Among the 162 included patients, 14 (8.6%) relapsed during the 52-week study period. The optimal cutoff score of K-ESS was 15 with a sensitivity of 71.43% and a specificity of 52.70%, indicating poor predictive accuracy of K-ESS. A lower cutoff K-ESS score of 3 and a higher cutoff score of 28 were found in the subgroups with milder (CGI-S = 1-2) and severer (CGI-S = 3-4) symptom severity, respectively, with fair to good predictive accuracy. The K-ESS showed acceptable concurrent validity with CGI-S and concordance rate between self-rated and informant-rated scores. Discussion The predictive accuracy of K-ESS was limited by evaluation interval of a month. At least fortnightly follow-up would be needed for detection of early signs to prevent a psychotic relapse in schizophrenia. | Kwon, Jun Soo; Lee, Junhee; Kim, Euitae; Kim, Sung-Wan; Jung, Hee Yeon; Lee, Kyu Young; Ryu, Vin; Lee, Seung Jae; Chon, Myong-Wuk; Choi, GumJee; Koh, MinJung; Kim, SuYoun | Seoul Natl Univ, Dept Psychiat, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea; Seoul Natl Univ, Dept Brain & Cognit Sci, Coll Nat Sci, 101 Daehak Ro, Seoul 03080, South Korea; Seoul Natl Univ, Inst Human Behav Med, Med Res Ctr, Seoul, South Korea; Seoul Natl Univ, Dept Psychiat, Bundang Hosp, Gyeonggi Do, South Korea; Chonnam Natl Univ, Dept Psychiat, Med Sch, Gwangju, South Korea; SMG SNU Boramae Med Ctr, Dept Psychiat, Seoul, South Korea; Eulji Univ, Dept Neuropsychiat, Sch Med, Daejeon, South Korea; Natl Ctr Mental Hlth, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Janssen Korea, Med Affairs, Seoul, South Korea | Lee, Jungmin/KHT-2438-2024; Lee, Seung/AAI-1191-2020 | 7202469012; 57196137310; 55756823600; 47962371200; 7403029787; 24376890800; 36461608800; 58509400200; 24597681800; 57210160941; 56162485500; 57218685477 | kwonjs@snu.ac.kr; | JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | J CLIN PSYCHOPHARM | 0271-0749 | 1533-712X | 40 | 5 | SCIE | PHARMACOLOGY & PHARMACY;PSYCHIATRY | 2020 | 3.153 | 55.6 | 0.09 | 2025-06-25 | 2 | 2 | early signs; prediction; relapse; schizophrenia; validity | TREATMENT RESPONSE; 1ST EPISODE | early signs; prediction; relapse; schizophrenia; validity | Adult; Antipsychotic Agents; Early Diagnosis; Female; Humans; Male; Predictive Value of Tests; Prospective Studies; Psychiatric Status Rating Scales; Recurrence; Schizophrenia; Schizophrenic Psychology; Seoul; Time Factors; Young Adult; neuroleptic agent; accuracy; adult; Article; disease severity; female; human; Korean (people); Korean Early Signs Scale; major clinical study; male; multicenter study; prediction; prospective study; relapse; schizophrenia; schizophrenia assessment; self concept; sensitivity and specificity; survival rate; survival time; clinical trial; early diagnosis; predictive value; psychological rating scale; psychology; recurrent disease; schizophrenia; South Korea; time factor; young adult | English | 2020 | 2020 (SEP-OCT) | 10.1097/jcp.0000000000001263 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Extracellular vesicles derived from macrophage promote angiogenesis In vitro and accelerate new vasculature formation In vivo | Background: Ischemia is the partial or complete blockage of blood supply to tissues. Extracellular vesicles (EVs) are emerging as a therapeutic tool for ischemic diseases. Most EV-based ischemia therapies are based on various stem cells. Here, we propose an alternative cell source for the isolation of pro-angiogenic EVs. Methods: EVs were isolated from a mouse macrophage cell line (Raw 264.7). The characteristic features of the macrophage-derived EVs (MAC-EVs) were assessed using transmission electron microscopy, nanoparticle tracking analysis, and Western blotting (WB) analysis. WB and qRT-PCR were performed to identify the proangiogenic VEGF and Wnt3a proteins and microRNAs (miR-210, miR-126, and miR-130a) in the MAC-EVs. In vitro and in vivo Matrigel plug assays were performed to investigate the capacity of the MAC-EVs for tube (blood vessel-like) formation and new blood vessel formation and assessed by histology. Results: The MAC-EVs was positive for ALIX and negative for calnexin, with a round shape and an average size of 189 +/- 65.1 nm. WB and qRT-PCR results revealed that VEGF, Wnt3a and miR-130a were more abundant in the MAC-EVs than cells. MAC-EVs treatment resulted in increased endothelial cellular proliferation, migration, and tube formation in vitro. In vivo assay results revealed that MAC-EVs increased the formation of new and larger blood vessels in the Matrigel plug of mice compared to the formation in the control group. Conclusion: Our results suggest that MAC-EVs have the potential to induce angiogenesis in vitro and in vivo, could serve as a pro-angiogenic alternative for ischemic diseases. | Gangadaran, Prakash; Rajendran, Ramya Lakshmi; Oh, Ji Min; Hong, Chae Moon; Jeong, Shin Young; Lee, Sang-Woo; Lee, Jaetae; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea | Gangadaran, Prakash/AAV-3102-2021; lee, sangwoo/KUD-1906-2024; Rajendran, Ramya/AAV-6338-2021; Lee, Jaetae/AAR-3317-2021 | 54393130400; 57195318729; 57190370462; 37050876700; 36164032500; 57196249819; 7601451907; 7202791511 | abc2000@knu.ac.kr; | EXPERIMENTAL CELL RESEARCH | EXP CELL RES | 0014-4827 | 1090-2422 | 394 | 2 | SCIE | CELL BIOLOGY;ONCOLOGY | 2020 | 3.905 | 55.6 | 1.75 | 2025-06-25 | 42 | 46 | Extracellular vesicle; Macrophage cell; miRNA; Angiogenesis | MESENCHYMAL STEM-CELLS; ACTIVATES VEGF RECEPTORS; LIMB ISCHEMIA; MOUSE MODEL; PROLIFERATION; MICRORNA; MIR-130A; INJURY | Angiogenesis; Extracellular vesicle; Macrophage cell; miRNA | Angiogenesis Inducing Agents; Animals; Cell Movement; Cell Proliferation; Collagen; Disease Models, Animal; Drug Combinations; Endothelial Cells; Extracellular Vesicles; Female; Fluorescence; Laminin; Macrophages; Mice; Mice, Nude; Neovascularization, Physiologic; Proteoglycans; RAW 264.7 Cells; calnexin; cell protein; matrigel; microRNA; microRNA 126; microRNA 130a; microRNA 210; nanoparticle; protein ALIX; unclassified drug; vasculotropin; Wnt3a protein; angiogenic factor; collagen; laminin; proteoglycan; angiogenesis; animal cell; animal experiment; animal tissue; Article; cell migration; cell proliferation; controlled study; endothelium cell; exosome; gene expression; histology; in vitro study; in vivo study; macrophage; macrophage cell line; macrophage culture; mouse; nonhuman; priority journal; protein expression; RAW 264.7 cell line; real time polymerase chain reaction; transmission electron microscopy; vascularization; Western blotting; animal; cell motion; disease model; drug combination; exosome; female; fluorescence; macrophage; metabolism; nude mouse; ultrastructure | English | 2020 | 2020-09-15 | 10.1016/j.yexcr.2020.112146 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: