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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Proposal of a Novel Serological Algorithm Combining FIB-4 and Serum M2BPGi for Advanced Fibrosis in Nonalcoholic Fatty Liver Disease | Background/Aims: Noninvasive methods have become increasingly critical in the diagnosis of fibrosis in chronic liver diseases. Herein, we compared the diagnostic performance of serum Mac2 binding protein glycosylation isomer (M2BPGi) and other serological panels for fibrosis in patients with nonalcoholic fatty liver disease (NAFLD) and proposed an improved two-step diag-nostic algorithm for advanced fibrosis.Methods: We enrolled 231 patients diagnosed with NAFLD who underwent a liver biopsy. We subsequently evaluated the diagnostic performance of serological panels, including serum M2B-PGi, a fibrosis index based on four factors (FIB-4), aspartate aminotransferase-to-platelet ratio index (APRI), and NAFLD fibrosis score (NFS), in predicting the stage of liver fibrosis. We then constructed a two-step algorithm to better differentiate advanced fibrosis.Results: The areas under the receiver operating characteristic curves of serum M2BPGi, FIB-4, APRI, and NFS for advanced fibrosis (& GE;F3) were 0.823, 0.858, 0.779, and 0.827, respectively. To reduce the performance of unnecessary liver biopsy, we propose a two-step algorithm using FIB-4 as an initial diagnostic tool and serum M2BPGi (& GE;0.6) as an additional diagnostic method for patients classified as intermediate (23%). Using the proposed algorithm, the sensitivity, speci-ficity, accuracy, positive predictive value, and negative predictive value were 0.812, 0.814, 0.814, 0.600, and 0.927, respectively.Conclusions: Serum M2BPGi is a simple and effective test for advanced fibrosis in patients with NAFLD. Application of the two-step algorithm based on FIB-4 and M2BPGi proposed here can improve diagnostic performance and reduce unnecessary tests, making diagnosis easily acces-sible, especially in primary medical centers. (Gut Liver, Published online August 14, 2023) | Moon, Sang Yi; Baek, Yang Hyun; Jang, Se Young; Jun, Dae Won; Yoon, Ki Tae; Cho, Young Youn; Jo, Hoon Gil; Jo, Ae Jeong | Dong A Univ, Dept Internal Med, Coll Med, Busan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Hanyang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Hanyang Univ, Hanyang Inst Biosci & Biotechnol, Seoul, South Korea; Pusan Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Pusan Natl Univ, Liver Ctr, Yangsan Hosp, Yangsan, South Korea; Chung Ang Univ Hosp, Dept Internal Med, Seoul, South Korea; Wonkwang Univ, Wonkwang Univ Hosp, Dept Internal Med, Div Gastroenterol,Coll Med, Iksan, South Korea; Andong Natl Univ, Dept Informat Stat, Andong, South Korea | ; Jun, Dae Won/O-4529-2017 | 56393618900; 15844799800; 57202881977; 57226004346; 14820137300; 55850994200; 57217410042; 57190185428 | p100100@dau.ac.kr;magnolia1103@naver.com; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 18 | 2 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.2 | 35.7 | 2.4 | 2025-05-07 | 6 | 5 | Non-alcoholic fatty liver disease; Mac-2 binding protein glycosylation isomer; Liver fibrosis | SIMPLE NONINVASIVE INDEX; NAFLD; STAGE; MORTALITY; SCORE; PREVALENCE; PREDICTION; SYSTEM; RISK | Liver fibrosis; Mac-2 binding protein glycosylation isomer; Non-alcoholic fatty liver disease | Aspartate Aminotransferases; Biomarkers; Biopsy; Glycosylation; Humans; Liver; Liver Cirrhosis; Liver Function Tests; Non-alcoholic Fatty Liver Disease; Predictive Value of Tests; ROC Curve; aspartate aminotransferase; binding protein; mac2 binding protein glycosylation isomer; unclassified drug; aspartate aminotransferase; biological marker; adult; Article; aspartate aminotransferase to platelet ratio index; classification algorithm; clinical assessment; computer assisted tomography; correlational study; diagnostic accuracy; diagnostic test accuracy study; female; Fibrosis-4 Index; human; liver biopsy; liver fibrosis; major clinical study; male; middle aged; NAFLD Fibrosis Score; nonalcoholic fatty liver; patient coding; prediction; predictive value; retrospective study; risk assessment; risk factor; sensitivity and specificity; transient elastography; unnecessary procedure; biopsy; glycosylation; liver; liver cirrhosis; liver function test; nonalcoholic fatty liver; pathology; receiver operating characteristic | English | 2024 | 2024-03 | 10.5009/gnl230128 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Quality Indicators of Endoscopic Retrograde Cholangiopancreatography in Korea | Endoscopic retrograde cholangiopancreatography (ERCP) is a procedure that requires significant experiences and skills and has various procedure-related complications, some of which can be severe and even result in the death of patients. Expanding ERCP availability has the advantage of increasing accessibility for patients. However, ERCP poses a substantial risk if performed without proper quality management. ERCP quality management is essential for both ensuring safe and successful procedures and meeting the social demands for enhanced healthcare competitiveness and quality assurance. To address these concerns, the Korean Pancreatobiliary Association established a task force to develop ERCP quality indicators (QIs) tailored to the Korean medical environment. Key questions for five pre-procedure, three intra-procedure, and four post-procedure measures were formulated based on a literature search related to ERCP QIs and a comprehensive clinical review conducted by experts. The statements and recommendations regarding each QI item were selected through peer review. The developed ERCP QIs were reviewed by external experts based on the latest available evidence at the time of development. These domestically tailored ERCP QIs are expected to contribute considerably to improving ERCP quality in Korea. (Gut Liver 2024;18:564-577) | Chon, Hyung Ku; Kim, Ki-Hyun; Song, Tae Jun; Ahn, Dong-Won; Lee, Eaum Seok; Lee, Yun Nah; Lee, Yoon Suk; Jeon, Tae Joo; Park, Chang Hwan; Cho, Kwang Bum; Lee, Dong Wook; Park, Jin-Seok; Yoon, Seung Bae; Chung, Kwang Hyun; Lee, Jin; Choi, Miyoung | Wonkwang Univ, Coll Med, Dept Internal Med, Iksan, South Korea; Inst Wonkwang Med Sci, Iksan, South Korea; Chonnam Natl Univ, Med Sch, Dept Internal Med, Gwangju, South Korea; Univ Ulsan, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul Metropolitan Govt, Seoul, South Korea; Chungnam Natl Univ, Coll Med, Dept Internal Med, Daejeon, South Korea; Soonchunhyang Univ, Sch Med, Dept Internal Med, Bucheon, South Korea; Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Internal Med, Goyang, South Korea; Inje Univ, Sanggye Paik Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Inha Univ, Sch Med, Dept Internal Med, Incheon, South Korea; Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Eulji Univ, Uijeongbu Eulji Med Ctr, Sch Med, Dept Internal Med, Uijongbu, South Korea; Hallym Univ, Dongtan Sacred Heart Hosp, Coll Med, Dept Internal Med,Div Gastroenterol, Hwaseong, South Korea; Natl Evidence based Healthcare Collaborating Agcy, Seoul, South Korea; Shihwa Med Ctr, Dept Internal Med, Shihung, South Korea; Soonchunhyang Univ, Coll Med, Seoul Hosp, Dept Internal Med,Div Gastroenterol, Seoul, South Korea | Lee, Yun/J-1260-2014; LEE, Yoon-Suk/D-1827-2019; Choi, Miyoung/HZH-8501-2023; Chon, Hyung ku/AGO-1334-2022; Lee, Yoon Suk/D-1827-2019; Song, Taejun/JVZ-2733-2024 | 57191108189; 57145000000; 26028951400; 14022272100; 41461392000; 57129189700; 57219432560; 57217483767; 57207441931; 7403956834; 57202974895; 16241892100; 35217323900; 57217552216; 7601478166; 57129603200 | p1052ccy@hanmail.net; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 18 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.2 | 35.7 | 0.48 | 2025-05-07 | 0 | 2 | Cholangiopancreatography; endoscopic retrograde; Quality improvement; Republic of Korea | POST-ERCP PANCREATITIS; RISK-FACTORS; GASTROINTESTINAL ENDOSCOPY; ANTIBIOTIC-PROPHYLAXIS; EUROPEAN-SOCIETY; INFECTIOUS COMPLICATIONS; SPHINCTEROTOMY; MANAGEMENT; CANNULATION; BACTEREMIA | Cholangiopancreatography; endoscopic retrograde; Quality improvement; Republic of Korea | Cholangiopancreatography, Endoscopic Retrograde; Humans; Quality Indicators, Health Care; Republic of Korea; acute pancreatitis; Article; biliary tract disease; bleeding; clinical effectiveness; common bile duct stone; endoscopic retrograde cholangiopancreatography; evidence based practice; health care quality; health care system; human; outcome assessment; pancreas disease; peer review; perforation; practice guideline; quality control; safety; South Korea; total quality management; procedures | English | 2024 | 2024-07 | 10.5009/gnl230427 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Therapeutic Effects of (+)-Afzelechin on Particulate Matter-Induced Pulmonary Injury | Particulate matter (PM) constitutes a hazardous blend of organic and inorganic particles that poses health risks. Inhalation of fine airborne PM with a diameter of <= 2.5 mu m (PM2.5) can lead to significant lung impairments. (+)-afzelechin (AZC), a natural compound sourced from Bergenia ligulata, boasts a range of attributes, including antioxidant, antimicrobial, anticancer, and cardiovascular effects. However, knowledge about the therapeutic potential of AZC for patients with PM2.5-induced lung injuries remains limited. Thus, in this study, we investigated the protective attributes of AZC against lung damage caused by PM2.5 exposure. AZC was administered to the mice 30 min after intratracheal instillation of PM2.5. Various parameters, such as changes in lung tissue wet/dry (W/D) weight ratio, total protein/total cell ratio, lymphocyte counts, levels of inflammatory cytokines in bronchoalveolar lavage fluid (BALF), vascular permeability, and histology, were evaluated in mice exposed to PM2.5. Data demonstrated that AZC mitigated lung damage, reduced W/D weight ratio, and curbed hyperpermeability induced by PM2.5 exposure. Furthermore, AZC effectively lowered plasma levels of inflammatory cytokines produced by PM2.5 exposure. It reduced the total protein concentration in BALF and successfully alleviated PM2.5-induced lymphocytosis. Additionally, AZC substantially diminished the expression levels of Toll-like receptors 4 (TLR4), MyD88, and autophagy-related proteins LC3 II and Beclin 1. In contrast, it elevated the protein phosphorylation of the mammalian target of rapamycin (mTOR). Consequently, the anti-inflammatory attribute of AZC positions it as a promising therapeutic agent for mitigating PM2.5-induced lung injuries by modulating the TLR4-MyD88 and mTOR-autophagy pathways. | Cho, Sanghee; Park, Yun Jin; Bae, Jong-Sup | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea | 58784915200; 58784741900; 16021543200 | baejs@knu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 32 | 1 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3.2 | 35.7 | 1.04 | 2025-04-16 | 1 | 2 | (+)-afzelechin; Particulate matter; Lung injury; TLR4-mTOR-autophagy pathway | NF-KAPPA-B; LUNG INJURY; ACTIVATION; PM2.5; GROWTH; CANCER; MTOR | (+)-afzelechin; Lung injury; Particulate matter; TLR4–mTOR–autophagy pathway | afzelechin; beclin 1; chemical compound; cytokine; dexamethasone; interleukin 1beta; mammalian target of rapamycin; mitogen activated protein kinase p38; myeloperoxidase; nitrous oxide; small interfering RNA; toll like receptor 4; tumor necrosis factor; unclassified drug; Akt/mTOR signaling; animal experiment; animal tissue; antiinflammatory activity; Article; autophagy (cellular); bicinchoninic acid assay; blood vessel permeability; bronchoalveolar lavage fluid; capillary endothelial cell; cell count; controlled study; enzyme linked immunosorbent assay; genetic transfection; histology; infant; inflammation; lung injury; lymphocyte count; lymphocytosis; male; mouse; nonhuman; particulate matter; particulate matter 2.5; particulate matter induced pulmonary injury; permeability; phosphorylation; post hoc analysis; protein expression level; therapy effect; Western blotting | English | 2024 | 2024-01 | 10.4062/biomolther.2023.187 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | A usability evaluation of a metaverse library: A case study of the “Community Virtual Library” | The purpose of this case study is to examine the usability evaluation of the metaverse library, with a central focus on designing around the needs of library users. To achieve this, our study delved into the usability of one such platform, the Community Virtual Library (CVL), focusing on aligning its features with user needs. We assessed the CVL based on Jacob Nielsen’s usability criteria: satisfaction, memorability, learnability, efficiency, and error tolerance, through specific tasks. Our methodology combined interviews, observations, and the System Usability Scale (SUS) to fully grasp the user experience. Furthermore, we explored users’ emotional responses using the Pleasure-Arousal-Dominance (PAD) model, enriching our understanding of their interaction with the platform. Throughout the analysis, we found that participants with metaverse experience showed higher success rates and spent less time on tasks compared to those who did not have such experience. Notably, while the tasks for learnability, focusing on basic functionalities, demonstrated relatively shorter durations, the slightly more intricate efficiency tasks took twice as long, regardless of metaverse familiarity. However, tasks for memorability, involving repetition of efficiency tasks, showed a marginal reduction in task duration. This underscores the potential to enhance usability and efficiency through education and learning initiatives. Meanwhile, the analysis indicated a high level of arousal according to the PAD model, underscoring the metaverse’s appeal in providing unrestricted access to diverse media and creating an engaging and novel environment. This study is expected to contribute significantly to evaluating and improving the usability of metaverse libraries, ultimately increasing user satisfaction and encouraging continued usage. By identifying areas for improvement through comprehensive assessments, we anticipate fostering a more enjoyable and efficient user experience within these virtual library environments. © The Author(s) 2024. | Kim, Yumi; Kim, Yeonhee; Kwon, Nuri; Kim, Heesop | Kyungpook National University, South Korea; Kyungpook National University, South Korea; Kyungpook National University, South Korea; Kyungpook National University, South Korea, National Library of Korea, South Korea | 59052191800; 59494040600; 59494040700; 8865330100 | heesop@knu.ac.kr; | Journal of Librarianship and Information Science | J LIBR INF SCI | 0961-0006 | 1741-6477 | SSCI | INFORMATION SCIENCE & LIBRARY SCIENCE | 2024 | 2.1 | 35.8 | 0.52 | 2025-05-07 | 2 | Case study; Community Virtual Library (CVL); metaverse library; Pleasure-Arousal-Dominance (PAD); System Usability Scale (SUS); usability evaluation | English | Article in press | 2024 | 10.1177/09610006241307389 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Complete chloroplast genome sequence of Artemisia littoricola (Asteraceae) from Dokdo Island Korea: genome structure, phylogenetic analysis, and biogeography study | The Asteraceae family, particularly the Artemisia genus, presents taxonomic challenges due to limited morphological characteristics and frequent natural hybridization. Molecular tools, such as chloroplast genome analysis, offer solutions for accurate species identification. In this study, we sequenced and annotated the chloroplast genome of Artemisia littoricola sourced from Dokdo Island, employing comparative analyses across six diverse Artemisia species. Our findings reveal conserved genome structures with variations in repeat sequences and junction boundaries. Notably, the chloroplast genome of A. littoricola spans 150,985 bp, consistent with other Artemisia species, and comprises 131 genes, including 86 protein-coding, 37 tRNA, and 8 rRNA genes. Among these genes, 16 possess a single intron, while clpP and ycf3 exhibit two introns each. Furthermore, 18 genes display duplicated copies within the IR regions. Moreover, the genome possesses 42 Simple Sequence Repeats (SSRs), predominantly abundant in A/T content and located within intergenic spacer regions. The analysis of codon usage revealed that the codons for leucine were the most frequent, with a preference for ending with A/U. While the chloroplast genome exhibited conservation overall, non-coding regions showed lower conservation compared to coding regions, with the Inverted Repeat (IR) region displaying higher conservation than single-copy regions. Phylogenetic analyses position A. littoricola within subgenus Dracunculus, indicating a close relationship with A. scoparia and A. desertorum. Additionally, biogeographic reconstructions suggest ancestral origins in East Asia, emphasizing Mongolia, China (North East and North Central and South Central China), and Korea. This study underscores the importance of chloroplast genomics in understanding Artemisia diversity and evolution, offering valuable insights into taxonomy, evolutionary patterns, and biogeographic history. These findings not only enhance our understanding of Artemisia's intricate biology but also contribute to conservation efforts and facilitate the development of molecular markers for further research and applications in medicine and agriculture. | Kadam, Suhas K.; Youn, Jin-Suk; Tamboli, Asif S.; Yang, Jiyoung; Pak, Jae Hong; Choo, Yeon-Sik | Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, Sch Life Sci, Dept Biol, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, Dept Biol, 80 Daehak Ro, Daegu 41566, South Korea | Kadam, Dr. Suhas/HNI-6437-2023; Tamboli, Asif/HJB-2803-2022 | 57188723669; 57210840807; 56974034100; 55193226000; 7102232932; 26040458100 | yschoo@knu.ac.kr; | FUNCTIONAL & INTEGRATIVE GENOMICS | FUNCT INTEGR GENOMIC | 1438-793X | 1438-7948 | 24 | 5 | SCIE | GENETICS & HEREDITY | 2024 | 3.1 | 35.9 | 0.44 | 2025-05-07 | 1 | 1 | Artemisia littoricola; Biogeography; Chloroplast genome; Dokdo Island; Phylogeny | NUCLEAR RIBOSOMAL DNA; GENUS ARTEMISIA; MOLECULAR PHYLOGENY; ANTHEMIDEAE; EVOLUTION; HYBRIDIZATION; TRIDENTATA; ALLIES; NRDNA; TOOL | Artemisia littoricola; Biogeography; Chloroplast genome; Dokdo Island; Phylogeny | Artemisia; Genome, Chloroplast; Microsatellite Repeats; Phylogeny; Phylogeography; Republic of Korea; Whole Genome Sequencing; cytochrome b6; cytochrome c; DNA directed RNA polymerase; proton transporting adenosine triphosphate synthase; reduced nicotinamide adenine dinucleotide dehydrogenase; ribulosebisphosphate carboxylase; microsatellite DNA; agar gel electrophoresis; Artemisia; Artemisia dracunculus; Artemisia littoricola; Artemisia scoparia; Article; carbon metabolism; cell hybridization; chloroplast; comparative effectiveness; controlled study; DNA extraction; fatty acid synthesis; gene sequence; gene structure; genetic transcription; genetic variability; genetic variation; high throughput sequencing; island biogeography; Markov chain Monte Carlo method; nonhuman; photosynthesis; photosystem I; photosystem II; phylogeny; plant structures; protein degradation; chloroplast genome; classification; genetics; phylogeography; South Korea; whole genome sequencing | English | 2024 | 2024-10 | 10.1007/s10142-024-01464-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Efficacy and safety of oral sulfate tablet vs. polyethylene glycol and ascorbate for bowel preparation in children | Background and aim Bowel preparation for pediatric colonoscopy presents several challenges. However, no bowel preparation regimen is universally preferred for children. We aimed to investigate the efficacy and safety of oral sulfate tablet (OST) in pediatric bowel preparation. Methods This study retrospectively analyzed data from children who received 2l of polyethylene glycol and ascorbate (PEG/Asc) or OST for bowel preparation between 2021 and 2023. A comparative analysis was conducted between the two groups. Results A total of 146 patients were included (2l PEG/Asc: 115, 73.0% vs. OST: 31). No significant difference was observed in the total BBPS score (median 8.0 vs. 8.0, P = 0.152) and the total OBPS score (median 5.0 vs. 3.0, P = 0.152) between the two groups. No significant difference was noted in the ratio of a bubble score of 0 (73.0% vs. 93.5%, P = 0.132). The incidence of abdominal pain was significantly lower in the OST group (32.2% vs. 3.2%, P = 0.002). The VAS score for overall satisfaction was significantly higher in the OST group (4.0 vs. 7.0, P < 0.001). For the next colonoscopy bowel preparation, a higher proportion of patients in the OST group showed a willingness to use the same preparation regimen (33.9% vs. 83.9%, P < 0.001). Conclusion OST was as efficacious and safe as 2 L of PEG/Asc for pediatric bowel preparation. The satisfaction level was higher with OST than with 2 L of PEG/Asc. OST may be considered a good alternative for children with poor compliance during bowel preparation. | Choi, Sujin; Kim, Ji Sook; Choe, Byung-Ho; Kang, Ben | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea | Choe, Byung-Ho/KSM-6251-2024; 康, 奔/JMQ-0812-2023 | 57223972405; 57194705685; 57574977300; 57194823199 | benkang@knu.ac.kr; | FRONTIERS IN PEDIATRICS | FRONT PEDIATR | 2296-2360 | 12 | SCIE | PEDIATRICS | 2024 | 2 | 35.9 | 0 | 2025-05-07 | 0 | 0 | bowel preparation; oral sulfate tablet; child; efficacy; safety | SODIUM-PHOSPHATE TABLETS; PEDIATRIC COLONOSCOPY; QUALITY STANDARDS; ENDOSCOPY; MULTICENTER; INDICATORS; PATTERNS; SCALES | bowel preparation; child; efficacy; oral sulfate tablet; safety | ascorbic acid; chloride; coolprep; electrolyte; macrogol; magnesium sulfate; orafang; potassium chloride; potassium sulfate; simethicone; sodium chloride; sodium sulfate; sulfate; abdominal pain; adolescent; Article; body mass; child; chloride blood level; colonoscopy; drug efficacy; drug safety; electrolyte blood level; female; human; intestine preparation; kidney function; kidney function test; laboratory test; major clinical study; male; nausea; retrospective study; risk assessment; satisfaction; tablet; visual analog scale | English | 2024 | 2024-02-08 | 10.3389/fped.2024.1277083 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Evaluating the performance of egami, kobayashi and sano scores in predicting IVIG resistance in infant kawasaki disease | Background This study aimed to evaluate the effectiveness of Egami, Kobayashi and Sano scores in predicting intravenous immunoglobulin (IVIG) resistance in infant Kawasaki disease (KD), considering its unique clinical presentation. Methods We retrospectively analysed 143 infants aged < 12 months and diagnosed with KD at a single centre from 2019 to 2023. Patients were divided into IVIG-resistant and IVIG-responsive groups. Demographic, clinical and laboratory data were compared between the groups. The diagnostic performance of Egami, Kobayashi and Sano scores in predicting IVIG resistance was evaluated using sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and area under the receiver operating characteristic curve (AUC). Additionally, we developed a new scoring system based on significant predictors identified in our cohort. Results Among 143 infants, 45 (31.5%) showed IVIG resistance. The IVIG-resistant group had a significantly higher rate of coronary artery lesions (15.6% vs. 5.1%, p = 0.036). Incomplete KD was observed in 61.5% of cases. Egami, Kobayashi and Sano scores exhibited low sensitivity (35.6%, 55.6% and 20%, respectively) and moderate specificity (77.6%, 63.3% and 95.9%, respectively) in predicting IVIG resistance. The AUC ranged from 0.583 to 0.674, indicating poor to fair discriminative ability. Our newly developed scoring system, based on total bilirubin and albumin levels, showed similar performance (AUC 0.633) to existing scores. Conclusions Existing Japanese risk scoring systems and our newly developed score showed limited effectiveness in predicting IVIG resistance in infant KD. The high proportion of incomplete presentation and IVIG resistance in infants highlights the need for age-specific risk assessment and management. Further research is necessary to develop more sophisticated, dedicated prediction model for IVIG resistance in infants with KD. | Lim, Young Tae; Kwon, Jung Eun; Kim, Yeo Hyang | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Div Pediat Cardiol, Childrens Hosp, Daegu, South Korea | 57197274340; 57194002366; 57032023800 | kimyhped@gmail.com; | BMC PEDIATRICS | BMC PEDIATR | 1471-2431 | 24 | 1 | SCIE | PEDIATRICS | 2024 | 2 | 35.9 | 1.07 | 2025-05-07 | 2 | 2 | Kawasaki disease; Infants; Intravenous immunoglobulin; IVIG resistance; Risk scores; Egami score; Kobayashi score; Sano score | INTRAVENOUS IMMUNOGLOBULIN; DIAGNOSIS | Egami score; Infants; Intravenous immunoglobulin; IVIG resistance; Kawasaki disease; Kobayashi score; Risk scores; Sano score | Drug Resistance; Female; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Infant; Male; Mucocutaneous Lymph Node Syndrome; Predictive Value of Tests; Retrospective Studies; ROC Curve; Sensitivity and Specificity; acetylsalicylic acid; alanine aminotransferase; albumin; aspartate aminotransferase; bilirubin; C reactive protein; immunoglobulin; methylprednisolone; immunoglobulin; immunologic factor; area under the curve; Article; cervical lymphadenopathy; cohort analysis; controlled study; diagnostic test accuracy study; drug dose reduction; echocardiography; egami score; erythrocyte sedimentation rate; female; hospitalization; human; infant; kobayashi score; major clinical study; male; mucocutaneous lymph node syndrome; predictive value; receiver operating characteristic; retrospective study; risk factor; sano score; scoring system; sensitivity and specificity; drug resistance; drug therapy; mucocutaneous lymph node syndrome | English | 2024 | 2024-09-28 | 10.1186/s12887-024-05035-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Glycinamide Facilitates Nanocomplex Formation and Functions Synergistically with Bone Morphogenetic Protein 2 to Promote Osteoblast Differentiation In Vitro and Bone Regeneration in a Mouse Calvarial Defect Model | Background: This study aimed to identify glycine analogs conducive to the formation of cell-absorbable nanocomplexes, enhancing collagen synthesis and subsequent osteogenesis in combination with BMP2 for improved bone regeneration. Methods: Glycine and its derivatives were assessed for their effects on osteogenic differentiation in MC3T3-E1 cells and human bone marrow mesenchymal stem cells (BMSCs) under osteogenic conditions or with BMP2. Osteogenic differentiation was assessed through alkaline phosphatase staining and real-time quantitative polymerase chain reaction (RT-qPCR). Nanocomplex formation was examined via scanning electron microscopy, circular dichroism, and ultraviolet-visible spectroscopy. In vivo osteogenic effects were validated using a mouse calvarial defect model, and bone regeneration was evaluated through micro-computed tomography and histomorphometric analysis. Results: Glycine, glycine methyl ester, and glycinamide significantly enhanced collagen synthesis and ALP activity in conjunction with an osteogenic medium (OSM). GA emerged as the most effective inducer of osteoblast differentiation marker genes. Combining GA with BMP2 synergistically stimulated ALP activity and the expression of osteoblast markers in both cell lines. GA readily formed nanocomplexes, facilitating cellular uptake through strong electrostatic interactions. In an in vivo calvarial defect mouse model, the GA and BMP2 combination demonstrated enhanced bone volume, bone volume/tissue volume ratio, trabecular numbers, and mature bone formation compared to other combinations. Conclusion: GA and BMP2 synergistically promoted in vitro osteoblast differentiation and in vivo bone regeneration through nanocomplex formation. This combination holds therapeutic promise for individuals with bone defects, showcasing its potential for clinical intervention. | Nam, Sang-Hyeon; Kim, Ju Ang; Lim, Soomin; Lee, Su Jeong; Kim, Chun-Ho; Bae, Jong-Sup; Boo, Yong Chool; Kim, Young-Jin; Park, Eui Kyun | Kyungpook Natl Univ, Inst Hard Tissue & Biotooth Regenerat, Sch Dent, Dept Oral Pathol & Regenerat Med, Daegu 41940, South Korea; Korea Inst Radiol & Med Sci, Lab Tissue Engn, Seoul 01812, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Daegu Catholic Univ, Dept Biomed Engn, Gyongsan 38430, South Korea | Kim, Yon/J-2743-2012; Kim, Ju Ang/LWI-0914-2024; Lee, Su-Jeong/AAH-8467-2021; Kim, Young-jin/GSD-3168-2022 | 57209806061; 55991948000; 57202647759; 57219236074; 16304279500; 16021543200; 6602899130; 56195058400; 37071072400 | yjkim@cu.ac.kr;epark@knu.ac.kr; | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | TISSUE ENG REGEN MED | 1738-2696 | 2212-5469 | 21 | 7 | SCIE | CELL & TISSUE ENGINEERING;ENGINEERING, BIOMEDICAL | 2024 | 4.1 | 35.9 | 0.57 | 2025-05-07 | 1 | 1 | Bone morphogenetic protein 2; Glycinamide HCl; Bone regeneration | SCAFFOLDS | Bone morphogenetic protein 2; Bone regeneration; Glycinamide HCl | Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Cell Differentiation; Cell Line; Disease Models, Animal; Glycine; Humans; Mesenchymal Stem Cells; Mice; Osteoblasts; Osteogenesis; Skull; Bone; Cell culture; Chlorine compounds; Collagen; Computerized tomography; Defects; Dichroism; Phosphatases; Polymerase chain reaction; Scanning electron microscopy; Stem cells; alkaline phosphatase; bone morphogenetic protein 2; cell marker; collagen; glycinamide; glycine derivative; glycine methyl ester; bone morphogenetic protein 2; glycine; Bone morphogenetic protein-2; Bone regeneration; Calvarial defects; Defect model; Glycinamide; Glycinamide HCl; In-vitro; In-vivo; Nanocomplexes; Osteoblast differentiation; animal experiment; animal model; animal tissue; Article; bone development; bone marrow mesenchymal stem cell; bone regeneration; bone volume fraction; calvaria; cell differentiation; circular dichroism; collagen synthesis; complex formation; controlled study; enzyme activity; human; human cell; in vitro study; in vivo study; male; marker gene; MC3T3-E1 cell line; micro-computed tomography; morphometry; mouse; nonhuman; osteoblast; protein expression; real time polymerase chain reaction; scanning electron microscopy; skull defect; staining; static electricity; synergistic effect; trabecular number; ultraviolet visible spectroscopy; animal; bone development; cell line; chemistry; disease model; drug effect; mesenchymal stem cell; metabolism; skull; Amino acids | English | 2024 | 2024-10 | 10.1007/s13770-024-00657-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | High-Speed Clearing and High-Resolution Staining for Analysis of Various Markers for Neurons and Vessels | Background:Tissue clearing enables deep imaging in various tissues by increasing the transparency of tissues, but there were limitations of immunostaining of the large-volume tissues such as the whole brain.Methods:Here, we cleared and immune-stained whole mouse brain tissues using a novel clearing technique termed high-speed clearing and high-resolution staining (HCHS). We observed neural structures within the cleared brains using both a confocal microscope and a light-sheet fluorescence microscope (LSFM). The reconstructed 3D images were analyzed using a computational reconstruction algorithm.Results:Various neural structures were well observed in three-dimensional (3D) images of the cleared brains from Gad-green fluorescent protein (GFP) mice and Thy 1-yellow fluorescent protein (YFP) mice. The intrinsic fluorescence signals of both transgenic mice were preserved after HCHS. In addition, large-scale 3D imaging of brains, immune-stained by the HCHS method using a mild detergent-based solution, allowed for the global topological analysis of several neuronal markers such as c-Fos, neuronal nuclear protein (NeuN), Microtubule-associated protein 2 (Map2), Tuj1, glial fibrillary acidic protein (GFAP), and tyrosine hydroxylase (TH) in various anatomical regions in the whole mouse brain tissues. Finally, through comparisons with various existing tissue clearing methodologies such as CUBIC, Visikol, and 3DISCO, it was confirmed that the HCHS methodology results in relatively less tissue deformation and higher fluorescence retention.Conclusion:In conclusion, the development of 3D imaging based on novel tissue-clearing techniques (HCHS) will enable detailed spatial analysis of neural and vascular networks present within the brain. | Park, Jung Min; Choi, Seock Hwan; Lee, Eun-Shil; Gum, Sang-Il; Hong, Sungkuk; Kim, Dong Sun; Han, Man-Hoon; Lee, Soung-Hoon; Oh, Ji Won | Yonsei Univ, Coll Med, Dept Anat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Anat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, BK21 Plus KNU Biomed Convergence Program, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Kyungpook Natl Univ, Biomed Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu, South Korea; Binaree Inc, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Yonsei Univ, Coll Med, Grad Sch Med Sci, Brain Korea 21 Project, Seoul, South Korea | ; Oh, Ji/AAZ-3153-2020; Lee, Seung/AAI-1191-2020; Kim, Dae/AAJ-7518-2021 | 57195987554; 9742645500; 25925922900; 57899021400; 57899203100; 57125070500; 57194067936; 26322530000; 36093206200 | greateondal84@yuhs.ac;G1@yuhs.ac; | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | TISSUE ENG REGEN MED | 1738-2696 | 2212-5469 | 21 | 7 | SCIE | CELL & TISSUE ENGINEERING;ENGINEERING, BIOMEDICAL | 2024 | 4.1 | 35.9 | 0 | 2025-05-07 | 0 | 0 | Ultrafast tissue clearing; High-resolution staining; 3D mapping; Neuroimaging; Vasculature | VIRTUAL-REALITY; BRAIN; ANATOMY; ORGANS | 3D mapping; High-resolution staining; Neuroimaging; Ultrafast tissue clearing; Vasculature | Animals; Biomarkers; Blood Vessels; Brain; Imaging, Three-Dimensional; Mice; Mice, Transgenic; Microscopy, Confocal; Microscopy, Fluorescence; Neurons; Staining and Labeling; Amino acids; Fluorescence; Histology; Imaging systems; Mammals; Neuroimaging; Neurons; Proteins; Tissue; Topology; glial fibrillary acidic protein; green fluorescent protein; membrane protein; microtubule associated protein 2; neuronal nuclear protein; protein c fos; protein Tuj1; tyrosine 3 monooxygenase; unclassified drug; yellow fluorescent protein; biological marker; 3-D mapping; Brain tissue; High resolution; High Speed; High-resolution staining; Mouse brain; Neural structures; Ultra-fast; Ultrafast tissue clearing; Vasculature; animal cell; animal tissue; Article; blood vessel; brain region; brain tissue; cerebellum; controlled study; fluorescence; high speed clearing and high resolution staining; hippocampus; hydrophilicity; image reconstruction; immunohistochemistry; mesencephalon; mouse; nerve cell; neuroimaging; nonhuman; process optimization; protein expression; reconstruction algorithm; three-dimensional imaging; animal; blood vessel; brain; confocal microscopy; fluorescence microscopy; metabolism; procedures; staining; three-dimensional imaging; transgenic mouse; Brain | English | 2024 | 2024-10 | 10.1007/s13770-024-00658-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Imaging of the vascular distribution of the outer ear using optical coherence tomography angiography for highly accurate positioning of a hearable sensor | Novel hearable technology is securely and comfortably positioned within the ear canal minimizing inaccuracies caused by accessory movements during activities. Despite extensive research on hearable technologies within the outer ear, there is a lack of research in the field of vascular imaging and quantitative analysis in the outer ear in vivo, which is one of the crucial factors to select the appropriate sensor position. Therefore, in this paper, we introduced optical coherence tomography angiography (OCTA)-based qualitative and quantitative analyses to visualize the inner vasculature of the outer ear to acquire vascular maps for microvascular assessments in vivo. By generating maximum amplitude projection images from three-dimensional blood vascular volume, we identified variations of blood vessel signal caused by the different biological characteristics and curvature of the ear among individuals. The performance of micro-vascular mapping using the proposed method was validated through the comparison and analysis of individual vascular parameters using extracted 20 vascular-related variables. In addition, we extracted pulsatile blood flow signals, demonstrating its potential to provide photoplethysmographic signals and ear blood maps simultaneously. Therefore, our proposed OCTA-based method for ear vascular mapping successfully provides quantitative information about ear vasculature, which is potentially used for determining the position of system-on-chip sensors for health monitoring in hearable devices. (c) 2024 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | Hong, Juyeon; Seong, Daewoon; Kang, Dongwan; Kim, Hyunmo; Jang, Jeong Hun; Jeon, Mansik; Kim, Jeehyun | Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea; Ajou Univ, Sch Med, Dept Otolaryngol, 206 World Cup Ro, Suwon 16499, South Korea | 58157239900; 57212512353; 58079924200; 58078407800; 26639429600; 24171094000; 7601373350 | jhj@ajou.ac.kr;msjeon@knu.ac.kr; | APL BIOENGINEERING | APL BIOENG | 2473-2877 | 8 | 2 | SCIE | ENGINEERING, BIOMEDICAL | 2024 | 4.1 | 35.9 | 0 | 2025-05-07 | 1 | 1 | HEART-RATE; TECHNOLOGY | Angiography; Blood; Blood vessels; Mapping; System-on-chip; Ear canal; Highly accurate; In-vivo; Maximum amplitude; Microvascular; Projection image; Qualitative and quantitative analysis; Sensor position; Vascular imaging; Vasculature; Optical tomography | English | 2024 | 2024-06-01 | 10.1063/5.0203582 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Implantation of Culture-Expanded Bone Marrow Derived Mesenchymal Stromal Cells for Treatment of Osteonecrosis of the Femoral Head | BACKGROUND: Although core decompression (CD) with stem cell for the treatment of osteonecrosis of the femoral head (ONFH) showed promising results in many reports, the efficacy remains uncertain. We aimed to evaluate the efficacy of CD with culture-expanded autologous bone marrow-derived mesenchymal stem cell (BM-MSC) implantation in early stage ONFH. METHODS: A total of 18 patients (22 hips) with ONFH who underwent CD with culture-expanded BM-MSC implantation from September 2013 to July 2020 were retrospectively reviewed. The median age was 35.0 years [interquartile range (IQR), 28.5-42.0], and the median follow-up period was 4.0 years (IQR, 2.0-5.3). The median number of MSCs was 1.06x10(8). To evaluate radiographic and clinical outcomes, Association Research Circulation Osseous (ARCO) classifications, Japanese Investigation Committee classification, combined necrotic angle (CNA) visual analogue scale (VAS) and Harris Hip Score (HHS) were checked at each follow-up. RESULTS: The preoperative stage of ONFH was ARCO 2 in 14 hips and ARCO 3a in 8 hips. The ARCO staging was maintained in 7 hips in ARCO 2 and 4 hips in ARCO 3a. The radiographic failure rate of ARCO 2 and 3a was 14.3 and 50%, respectively. Furthermore, CNA decreased to more than 20 degrees in 6 hips (four were ARCO 2 and two were ARCO 3a).There was no significant difference in the VAS and HHS (P = 0.052 and P = 0.535, respectively). Total hip arthroplasty was performed in 4 hips. CONCLUSION: CD with culture-expanded autologous BM-MSCs showed promising results for the treatment of early stage ONFH. | Yoon, Seong-Dae; Shim, Bum-Jin; Baek, Seung-Hoon; Kim, Shin-Yoon | Kyungpook Natl Univ, Dept Orthoped Surg, Coll Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Orthoped Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Yeungnam Univ, Yeungnam Univ Hosp, Dept Orthoped Surg, Coll Med, 170 Hyeonchung Ro, Daegu 42415, South Korea | Kim, Soo/J-5411-2012 | 56655786400; 57201499293; 56232924900; 26663842900 | syukim@knu.ac.kr; | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | TISSUE ENG REGEN MED | 1738-2696 | 2212-5469 | 21 | 6 | SCIE | CELL & TISSUE ENGINEERING;ENGINEERING, BIOMEDICAL | 2024 | 4.1 | 35.9 | 1.15 | 2025-05-07 | 1 | 2 | Core decompression; Femoral head; Osteonecrosis; Stem cell | CORE-DECOMPRESSION; AVASCULAR NECROSIS; STEM-CELLS; HIP OSTEONECROSIS; FOLLOW-UP; COLLAPSE; THERAPY; CLASSIFICATION; PREDICTION | Core decompression; Femoral head; Osteonecrosis; Stem cell | Adult; Bone Marrow Cells; Cells, Cultured; Decompression, Surgical; Female; Femur Head Necrosis; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Middle Aged; Retrospective Studies; Transplantation, Autologous; Treatment Outcome; Arthroplasty; Bone; Cell culture; Clinical research; Failure analysis; Flowcharting; Orthopedics; Bone marrow-derived mesenchymal stem cells; Bone-marrow-derived mesenchymal stem cells; Core decompression; Femoral heads; Follow up; Inter quartile ranges; Osteonecrosis; Stem cell implantation; Stem-cell; Visual analog scale; adult; Article; bone radiography; clinical article; clinical outcome; female; femur head necrosis; follow up; Harris hip score; human; male; mesenchymal stromal cell therapy; middle aged; preoperative care; retrospective study; total hip replacement; treatment planning; trend study; visual analog scale; weight bearing; autotransplantation; bone marrow cell; cell culture; cytology; decompression surgery; femur head necrosis; mesenchymal stem cell; mesenchymal stem cell transplantation; metabolism; procedures; therapy; treatment outcome; Stem cells | English | 2024 | 2024-08 | 10.1007/s13770-024-00647-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Incidence and survival rates of primary cutaneous malignancies in Korea, 1999-2019: A nationwide population-based study | Primary cutaneous malignancies are among the most commonly diagnosed types of cancer worldwide. We aimed to examine the incidence and 5-year survival rates of all types of primary cutaneous malignancies in the Korean population. Data from the Korean Nationwide Cancer Registry from 1999 to 2019 were analyzed. The crude incidence rates, age-standardized incidence rates, and 5-year relative survival rates of each type of skin cancer were calculated. A total of 89 965 patients were diagnosed with primary cutaneous malignancies, which was a 7-fold increase from 1999 to 2019. The age-standardized incidence rates increased 3.4-fold in basal cell carcinoma (3.7/100 000 person-years), 2.0-fold in squamous cell carcinoma (1.6/100 000 person-years), 12.0-fold in Bowen disease (1.2/100 000 person-years), and 1.8-fold in malignant melanoma (0.7/10 000 person-years) in 2019. Average annual percentage changes in age-standardized incidence rates were statistically significant in basal cell carcinoma (15.8%), Bowen disease (5.8%), squamous cell carcinoma (5.1%), malignant melanoma (1.2%), melanoma in situ (1.1%), dermatofibrosarcoma protuberans (1.2%), mycosis fungoides (0.5%), primary cutaneous CD30+ T-cell proliferations (0.5%), adnexal and skin appendage carcinoma (0.4%), extramammary Paget's disease (0.2%), and Merkel cell carcinoma (0.2%). The 5-year relative survival rates were the highest in basal cell carcinoma (103.3%), followed by dermatofibrosarcoma protuberans (99.7%) and mycosis fungoides (96.6%), and lowest in angiosarcoma (24.7%). The 5-year relative survival rates steadily increased in extramammary Paget's disease (23.6%), cutaneous B-cell lymphoma (21.3%), mycosis fungoides (20.2%), extranodal NK/T-cell lymphoma, nasal type (18.1%), and malignant melanoma (16.1%) from 1996-2000 to 2015-2019. Most primary cutaneous malignancies have increased in incidence and survival rates in the Korean population, but to varying extents depending on the type of skin cancer. | Kwon, Soon-Hyo; Choi, Sangmin; Kim, Joung Soo; Kim, Sang Seok; Jue, Mihn-Sook; Seo, Soo Hong; Park, Jihye; Roh, Mi Ryung; Mun, Je-Ho; Kim, Jun Young; Choi, Jee Woong; Byun, Ji Won; Park, Sanghyun; Kim, Min Sung; Lee, Seok-Jong | Kyung Hee Univ, Sch Med, Dept Dermatol, Kyung Hee Univ Hosp Gangdong, Seoul, South Korea; Hanyang Univ, Guri Hosp, Dept Dermatol, Guri, South Korea; Hallym Univ, Coll Med, Kangdong Sacred Heart Hosp, Dept Dermatol, Seoul, South Korea; Hanyang Univ Hosp, Dept Dermatol, Seoul, South Korea; Korea Univ, Anam Hosp, Dept Dermatol, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Dermatol, Seoul, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Dermatol, Coll Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Dermatol, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Dermatol, Daegu, South Korea; Ajou Univ, Dept Dermatol, Sch Med, Suwon, South Korea; Inha Univ, Sch Med, Dept Dermatol, Incheon, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Dermatol, Hwasun, Jeollanam Do, South Korea; Chosun Univ, Sch Med, Dept Dermatol, Gwangju, South Korea | ; Kim, Hak-Jae/Q-9368-2019; Roh, Mi/ABG-7059-2020; Kwon, Soon-Hyo/ABG-9309-2020; Lee, Joong/A-5417-2013 | 50861268500; 57956718200; 35102450900; 14519479500; 35102158500; 7202469834; 57211684961; 7005347908; 37052613800; 35310922800; 57212392317; 36128418100; 57290278400; 57205109104; 56013454400 | seokjong@knu.ac.kr; | JOURNAL OF DERMATOLOGY | J DERMATOL | 0385-2407 | 1346-8138 | 51 | 4 | SCIE | DERMATOLOGY | 2024 | 2.7 | 35.9 | 0 | 2025-05-07 | 0 | 0 | epidemiology; incidence; skin neoplasms; survival rate | CELL CARCINOMA; SKIN CANCERS; PREVALENCE; MORTALITY; MELANOMA | epidemiology; incidence; skin neoplasms; survival rate | Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Child, Preschool; Dermatofibrosarcoma; Humans; Incidence; Melanoma; Mycosis Fungoides; Paget Disease, Extramammary; Republic of Korea; Skin Neoplasms; Survival Rate; adult; age; and skin appendage carcinoma; angiosarcoma; Article; average annual perceptage; basal cell carcinoma; Bowen disease; cancer incidence; cancer registry; controlled study; crude incidence rate; cutaneous B cell lymphoma; dermatofibrosarcoma protuberans; extranodal nasal NK/T cell lymphoma; female; human; Korea; major clinical study; male; mathematical analysis; melanoma; melanoma in situ; mycosis fungoides; Paget skin disease; population based case control study; primary cutaneous CD30+ T cell lymphoproliferative disorder; primary cutaneous malignancy; skin cancer; squamous cell carcinoma; standardized incidence ratio; statistical significance; survival rate; survival time; basal cell carcinoma; Bowen disease; dermatofibrosarcoma protuberans; incidence; melanoma; mycosis fungoides; Paget skin disease; preschool child; skin tumor; South Korea; squamous cell carcinoma; survival rate | English | 2024 | 2024-04 | 10.1111/1346-8138.17118 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Platelet-Rich Plasma-Embedded Porous Polycaprolactone Film with a Large Surface Area for Effective Hemostasis | Background:Uncontrollable and widespread bleeding caused by surgery or sudden accidents can lead to death if not treated with appropriate hemostasis. To prevent excessive life-threatening bleeding, various hemostatic agents based on polymeric biomaterials with various additives for accelerated blood coagulation have been adopted in clinical fields. In particular, platelet-rich plasma (PRP), which contains many blood coagulation factors that can accelerate blood clot formation, is considered as one of the most effective hemostatic additives.Methods:We investigated a PRP-embedded porous film using discarded (expired) PRP and a film with a leaf-stacked structure (FLSS), as a hemostatic agent to induce rapid hemostasis. The film, which contained an LSS on one side (PCL-FLSS), was fabricated by a simple heating-cooling technique using tetraglycol and polycaprolactone (PCL) film. Activated PRP was obtained by the thawing of frozen PRP at the end of its expiration date (the platelet cell membrane is disrupted during the freezing and thawing of PRP, thus releasing various coagulation factors) and embedded in the PCL-FLSS (PRP-FLSS).Results:From in vitro and in vivo experiments using a rat hepatic bleeding model, it was recognized that PRP-FLSS is not only biocompatible but also significantly accelerates blood clotting and thus prevents rapid bleeding, probably due to a synergistic effect of the sufficient supply of various blood coagulants from activated PRP embedded in the LSS layer and the large surface area of the LSS itself.Conclusion:The study suggests that PRP-FLSS, a combination of a porous polymer matrix with a unique morphology and discarded biofunctional resources, can be an advanced hemostatic agent as well as an upcycling platform to avoid the waste of biofunctional resources. | Kim, Min Ji; Song, Ye Jin; Kwon, Tae Gyun; Lee, Jin Ho; Chun, So Young; Oh, Se Heang | Dankook Univ, Dept Nanobiomed Sci, Cheonan 31116, South Korea; Kyungpook Natl Univ, Chilgok Kyungpook Natl Univ Hosp, Sch Med, Dept Urol, Daegu 41404, South Korea; Hannam Univ, Dept Adv Mat, Daejeon 34054, South Korea; Kyungpook Natl Univ Hosp, BioMed Res Inst, Daegu 41404, South Korea | Lee, Jin-Ho/AEE-5544-2022 | 58366170000; 59177392800; 15073765400; 57210580076; 8688166900; 7404104355 | seheangoh@dankook.ac.kr; | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | TISSUE ENG REGEN MED | 1738-2696 | 2212-5469 | 21 | 7 | SCIE | CELL & TISSUE ENGINEERING;ENGINEERING, BIOMEDICAL | 2024 | 4.1 | 35.9 | 0.57 | 2025-05-07 | 0 | 1 | Platelet-rich plasma; Hemostatic agent; Blood recycling; Leaf-stacked structure | COAGULATION; AGENTS; MODEL | Blood recycling; Hemostatic agent; Leaf-stacked structure; Platelet-rich plasma | Animals; Blood Coagulation; Hemorrhage; Hemostasis; Hemostatics; Humans; Male; Platelet-Rich Plasma; Polyesters; Porosity; Rats; Rats, Sprague-Dawley; Additives; Biocompatibility; Coagulation; Cytology; Morphology; Thawing; blood clotting factor; glycol; hemostatic agent; polycaprolactone; tetraglycol; unclassified drug; hemostatic agent; polycaprolactone; polyester; Bleedings; Blood coagulation; Blood recycling; Haemostasis; Hemostatic agents; Large surface area; Leaf-stacked structure; Platelet rich plasma; Polycaprolactone films; Stacked structure; animal cell; animal experiment; animal model; Article; blood clot; blood clotting; cell membrane; clinical evaluation; controlled study; cooling; cytotoxicity; embedding; expiration date; freeze thawing; heating; hemolysis; hemolysis assay; hemostasis; hydrophilicity; in vitro study; in vivo study; liver hemorrhage; microtechnology; nonhuman; rat; synergistic effect; thrombocyte; thrombocyte rich plasma; vascularization; animal; bleeding; chemistry; drug effect; human; male; porosity; Sprague Dawley rat; Platelets | English | 2024 | 2024-10 | 10.1007/s13770-024-00656-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ultrasonographic evaluation of nail matrix topography for preservative nail surgery of nail unit melanoma | Recently, functional or preservative surgery has been preferred for nail unit melanoma; however, complete resection of the nail unit, particularly the matrix, is challenging because of its complex structure. This study aims to measure the distance of important nail structures through ultrasonography. Herein, 14 patients without nail deformity were included. The length from the nail cuticle to the distal interphalangeal joint (distance X), to the attachment part of the extensor muscle (distance A), to the median proximal end of the nail matrix (distance B), and to the lateral proximal end of the nail matrix (distance C) were measured. In the axial plane, the length from the highest point of the nail plate to the bottom of the distal phalanx (distance Y) and to the lateral tip of the nail plate (distance D) were measured. On the first fingernail, third fingernail, first toenail, and third toenail, the mean ratio A:X, ratio B:X, ratio C:X, and ratio D:Y were 78.6%, 44.3%, 57.2%, 40.1%, and 84.6%; 55.9%, 64.9%, 40.2%, and 66.4%; 35.6%, 50.8%, 34.3%, and 81.9%; and 57.2%, 59.6%, and 31.7%, respectively. Nail units are often invisible to the naked eye; thus, this study will help identify the approximate scope of excision. | Ha, Gi Ung; Kim, Jin Ho; Ha, Dae-Lyong; Lee, Hoseok; Lee, Seok-Jong | Kyungpook Natl Univ, Sch Med, Dept Dermatol, 130 Dongdeok Ro, Daegu, South Korea; Semyung Radiol Clin, Gumi, South Korea | Lee, Joong/A-5417-2013 | 57783275400; 58508499500; 57201367090; 57200653487; 56013454400 | seokjong@knu.ac.kr; | JOURNAL OF DERMATOLOGY | J DERMATOL | 0385-2407 | 1346-8138 | 51 | 8 | SCIE | DERMATOLOGY | 2024 | 2.7 | 35.9 | 0 | 2025-05-07 | 0 | 0 | functional surgery; melanoma; nail unit melanoma; ultrasonography | MANAGEMENT | functional surgery; melanoma; nail unit melanoma; ultrasonography | Adult; Aged; Female; Humans; Male; Melanoma; Middle Aged; Nail Diseases; Nails; Skin Neoplasms; Ultrasonography; amputation; Article; clinical article; clinical assessment; cutaneous parameters; echography; finger nail; human; length from the highest point of the nail plate to the bottom of the distal phalanx; length from the nail cuticle to the attachment part of the extensor muscle; length from the nail cuticle to the distal interphalangeal joint; length from the nail cuticle to the lateral proximal end of the nail matrix; length from the nail cuticle to the median proximal end of the nail matrix; medical procedures; nail matrix topography; nail surgery; subungual melanoma; toe nail; adult; aged; diagnostic imaging; female; male; melanoma; middle aged; nail; nail disease; pathology; skin tumor; surgery | English | 2024 | 2024-08 | 10.1111/1346-8138.17340 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Differences in factors associated with insomnia symptoms between patients with epilepsy with and without depressive symptoms | Objective: To determine if insomnia-related factors differ depending on the presence of depression in patients with epilepsy. Methods: This cross-sectional multicenter study collected data on depressive symptoms, insomnia symptoms, and excessive daytime sleepiness, which were defined as a Patient Health Questionnaire-9 (PHQ-9) score of >= 10, an Insomnia Severity Index (ISI) score of >= 15, and an Epworth Sleepiness Scale (ESS) of >= 11, respectively. Further, uncontrolled seizures were defined as one or more seizures per month during antiseizure medications treatment. A stepwise logistic regression analysis was conducted, with a logistic regression with interaction terms performed to identify differences in insomnia-related factors depending on depressive symptoms. Results: Of 282 adults with epilepsy (men, 58 %; mean age, 40.4 +/- 13.9 years), a PHQ-9 score >= 10, an ISI score >= 15, an ESS score >= 11 were noted in 23.4 % (n = 66), 20.2 % (n = 57), and 12.8 % (n = 36), respectively. More patients with depressive symptoms had an ISI score >= 15 (56.1 % vs. 9.3 %; p = 15; however, this was only true in patients without depressive symptoms. In contrast, use of perampanel (OR, 0.282; p = 15 only in patients with depressive symptoms. Conclusions: Insomnia-related factors in patients with epilepsy may differ between patients with and without depression. Our findings of different insomnia-related factors based on the presence of depression may facilitate the management of patients with epilepsy. | Lee, Sang-Ahm; Choi, Eun Ju; Kim, Hyun-Woo; Jeon, Ji-Ye; Han, Su-Hyun; Lee, Gha-Hyun; Ryu, Han Uk; Kim, Boyoung; Kim, Tae-Young | Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Chung Ang Univ, Coll Med, Dept Neurol, Seoul, South Korea; Pusan Natl Univ Hosp, Dept Neurol, Biomed Res Inst, Pusan, South Korea; Jeonbuk Natl Univ, Sch Med & Hosp, Dept Neurol, Jeonju, South Korea; Jeonbuk Natl Univ, Sch Med & Hosp, Res Inst Clin Med, Jeonju, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, 88 Olymp Ro 43 Gil, Seoul 138736, South Korea | Kim, Yong-Tae/HQZ-0240-2023; Lee, Gha-hyun/HHN-8692-2022; Lee, Dong/J-2778-2012; Choi, Eunju/IUO-8098-2023 | 57190211641; 56309158700; 57226027023; 57194943660; 12784871800; 37661749600; 56516063800; 58895301200; 58895524100 | salee@amc.seoul.kr; | EPILEPSY & BEHAVIOR | EPILEPSY BEHAV | 1525-5050 | 1525-5069 | 156 | SCIE | BEHAVIORAL SCIENCES;CLINICAL NEUROLOGY;PSYCHIATRY | 2024 | 2.3 | 36.0 | 0 | 2025-05-07 | 0 | 0 | Epilepsy; Sleep disturbance; Insomnia; Depression; Daytime sleepiness; Perampanel | SUBJECTIVE SLEEP DISTURBANCE; ADJUNCTIVE PERAMPANEL; DAYTIME SLEEPINESS; QUALITY; PREVALENCE; VALIDATION; SEVERITY; ARCHITECTURE; LAMOTRIGINE; DISORDERS | Daytime sleepiness; Depression; Epilepsy; Insomnia; Perampanel; Sleep disturbance | Adult; Anticonvulsants; Cross-Sectional Studies; Depression; Epilepsy; Female; Humans; Logistic Models; Male; Middle Aged; Severity of Illness Index; Sleep Initiation and Maintenance Disorders; Surveys and Questionnaires; Young Adult; perampanel; anticonvulsive agent; adult; Article; cross-sectional study; depression; disease association; drug use; epilepsy; Epworth sleepiness scale; excessive daytime sleepiness; female; human; insomnia; Insomnia Severity Index; male; medical history; multicenter study (topic); Patient Health Questionnaire 9; seizure; uncontrolled seizure; clinical trial; complication; epidemiology; middle aged; multicenter study; psychology; questionnaire; severity of illness index; statistical model; young adult | English | 2024 | 2024-07 | 10.1016/j.yebeh.2024.109781 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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