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| ○ | ○ | Article | Neutralizing Antibody Responses to SARS-CoV-2 in Korean Patients Who Have Recovered from COVID-19 | Purpose: Neutralizing antibodies (NAbs) have been considered effective in preventing and treating viral infections. However, until now, the duration and clinical implications of antibody-mediated nature immunity in Koreans have remained unknown. Therefore, we examined NAbs levels and clinical characteristics in recovered coronavirus disease 2019 (COVID-19) patients. Materials and Methods: Blood samples were collected from 143 adult patients who had been diagnosed with and had recovered from COVID-19 from February to March in 2020 at a tertiary-care university-affiliated hospital in Daegu, Korea. A plaque reduction neutralization test was conducted to analyze NAb titers. Individualized questionnaires were used to identify patient clinical information. Results: The median number of days from symptom onset to the blood collection date was 109.0 (104.0; 115.0). The NAb titers ranged from 10 to 2560. The median NAb titer value was 40. Of the 143 patients, 68 (47.6%) patients had NAb titers >= 80, and 31 (21.7%) patients had NAb titers >= 160. The higher the age or disease severity, the higher the NAb titer. In univariate logistic regression, statistically significant predictors of high NAb titers (>= 80) were age, myalgia, nausea or vomiting, dyspnea, and disease severity (p= 50 years (p=0.013) and moderate or higher disease severity (p= 80). None of the patients had reinfection of COVID-19. Conclusion: All recovered patients were found to have NAbs regardless of the NAb titers maintained by natural immunity. Age and disease severity during COVID-19 infection were associated with high NAb titers. | Kim, Yoon-Jung; Bae, Joon-Yong; Bae, Sohyun; Hwang, Soyoon; Kwon, Ki Tae; Chang, Hyun-Ha; Lee, Won Kee; Cui, Chunguang; Lee, Gee Eun; Kim, Shin-Woo; Park, Man-Seong | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Korea Univ, Coll Med, Inst Viral Dis, Dept Microbiol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Med Informat, Daegu, South Korea | ; Kim, Hanjin/KYP-2633-2024; Hwang, Soyoon/HHM-5762-2022; Kim, Sooyeon/AAA-8521-2022; Kim, Ji Hoon/AAB-4602-2022 | 57203160508; 55201437800; 57219699506; 57203160675; 9733850500; 7407521688; 22953484700; 57222076048; 57222339643; 57189703358; 7404491121 | ksw2kms@knu.ac.kr;ms0392@korea.ac.kr; | YONSEI MEDICAL JOURNAL | YONSEI MED J | 0513-5796 | 1976-2437 | 62 | 7 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 3.052 | 48.0 | 1.03 | 2025-07-30 | 9 | 9 | COVID-19; SARS-CoV-2; neutralizing antibodies; immunity; neutralization assay | CONVALESCENT PLASMA; DISEASE | COVID-19; Immunity; Neutralization assay; Neutralizing antibodies; SARS-CoV-2 | Adult; Antibodies, Neutralizing; Antibodies, Viral; COVID-19; Humans; Middle Aged; Republic of Korea; SARS-CoV-2; neutralizing antibody; neutralizing antibody; virus antibody; adult; ageusia; allergic rhinitis; anosmia; antibody response; Article; artificial ventilation; blood sampling; body height; body temperature; body weight; cognitive defect; controlled study; coronavirus disease 2019; diabetes mellitus; diarrhea; disease duration; disease severity; dizziness; dyspnea; erythema; fatigue; female; fever; headache; heart arrhythmia; heart failure; heart palpitation; hematologic malignancy; human; hypertension; ID50; immunity; insomnia; intensive care unit; Korean (people); major clinical study; male; mental disease; myalgia; nausea and vomiting; oxygen therapy; oxygenation; paresthesia; plaque reduction neutralization test; pneumonia; polymerase chain reaction; questionnaire; real time reverse transcription polymerase chain reaction; reinfection; rhinorrhea; Severe acute respiratory syndrome coronavirus 2; sore throat; thorax pain; virus neutralization; middle aged; South Korea | English | 2021 | 2021-07 | 10.3349/ymj.2021.62.7.584 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | New Scoring System for Predicting Mortality in Patients with COVID-19 | Purpose: We aimed to develop a novel mortality scoring system for inpatients with COVID-19 based on simple demographic factors and laboratory findings. Materials and Methods: We reviewed and analyzed data from patients who were admitted and diagnosed with COVID-19 at 10 hospitals in Daegu, South Korea, between January and July 2020. We randomized and assigned patients to the development and validation groups at a 70% to 30% ratio. Each point scored for selected risk factors helped build a new mortality scoring system using Cox regression analysis. We evaluated the accuracy of the new scoring system in the development and validation groups using the area under the curve. Results: The development group included 1232 patients, whereas the validation group included 528 patients. In the development group, predictors for the new scoring system as selected by Cox proportional hazards model were age >₇₀ years, diabetes, chronic kidney disease, dementia, C-reactive protein levels >4 mg/dL, infiltration on chest X-rays at the initial diagnosis, and the need for oxygen support on admission. The areas under the curve for the development and validation groups were 0.914 [95% confidence interval (CI) 0.891-0.937] and 0.898 (95% CI 0.854-0.941), respectively. According to our scoring system, COVID-19 mortality was 0.4% for the low-risk group (score 0-3) and 53.7% for the very high-risk group (score >₁₁). Conclusion: We developed a new scoring system for quickly and easily predicting COVID-19 mortality using simple predictors. This scoring system can help physicians provide the proper therapy and strategy for each patient. | Bae, Sohyun; Kim, Yoonjung; Hwang, Soyoon; Kwon, Ki Tae; Chang, Hyun-Ha; Kim, Shin-Woo | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis, 130 Dongdeok Ro, Daegu 41944, South Korea | ; Kim, Ji Hoon/AAB-4602-2022; Kim, Sooyeon/AAA-8521-2022; Kim, Hanjin/KYP-2633-2024; Hwang, Soyoon/HHM-5762-2022 | 57219699506; 57203160508; 57203160675; 9733850500; 7407521688; 8710731500 | ksw2kms@knu.ac.kr; | YONSEI MEDICAL JOURNAL | YONSEI MED J | 0513-5796 | 1976-2437 | 62 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 3.052 | 48.0 | 0.8 | 2025-07-30 | 9 | 8 | COVID-19; mortality; scoring system | Mortality; Scoring system; COVID-19 | Aged; COVID-19; Hospitalization; Humans; Proportional Hazards Models; Risk Factors; SARS-CoV-2; alanine aminotransferase; aspartate aminotransferase; bilirubin; C reactive protein; creatinine; glucose; hemoglobin; lactate dehydrogenase; adult; aged; Article; asthma; body temperature; case fatality rate; chronic kidney failure; chronic liver disease; chronic obstructive lung disease; cohort analysis; controlled study; coronavirus disease 2019; dementia; diabetes mellitus; disease severity; female; heart failure; hematologic disease; hospitalization; human; hypertension; intensive care unit; leukocyte count; major clinical study; male; malignant neoplasm; measurement accuracy; mental disease; mortality; mortality rate; neurologic disease; oxygen therapy; platelet count; predictive value; real time reverse transcription polymerase chain reaction; receiver operating characteristic; retrospective study; risk factor; scoring system; sensitivity and specificity; thorax radiography; urea nitrogen blood level; proportional hazards model; randomized controlled trial | English | 2021 | 2021-09 | 10.3349/ymj.2021.62.9.806 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prognostic Value of Alpha-Fetoprotein in Patients Who Achieve a Complete Response to Transarterial Chemoembolization for Hepatocellular Carcinoma | Purpose: Alpha-fetoprotein (AFP) is a prognostic marker for hepatocellular carcinoma (HCC). We investigated the prognostic value of AR levels in patients who achieved complete response (CR) to transarterial chemoembolization (TACE) for HCC. Materials and Methods: Between 2005 and 2018, 890 patients with HCC who achieved a CR to TACE were recruited. An MP responder was defined as a patient who showed elevated levels of APP (>10 ng/mL) during 'FACE, but showed normalization or a >50% reduction in AFP levels after achieving a CR. Results: Among the recruited patients, 569 (63.9%) with naive 11a: and 321 (36.1%) with recurrent HCC after complete resection were treated. Before TACE, 305 (34.3%) patients had multiple tumors, 219 (24.6%) had a maximal tumor size >3 cm, and 22 (2.5%) had portal vein tumor thrombosis. The median All' level after achieving a CR was 6.36 ng/mL. After a CR, 473 (53.1%) patients experienced recurrence, and 417 (46.9%) died [median progression-free survival (PFS) and overall survival (OS) of 1 6.3 and 62.8 months, respectively]. High AFT levels at CR (>20 ng/mL) were independently associated with a shorter PFS [hazard ratio (HR)=1.403] and OS (H R=1.2114), together with tumor multiplicity at 'FACE (H R=1.51.8 and 1.666, respectively). AR non-responders at CR (76.2%, n=359 of 471) showed a shorter PPS (median 10.5 months vs. 15.5 months, HR=1.375) and OS (median 41.4 months vs. 61.8 months, HR=1.424) than AFP responders (all p=0.001). Conclusion: High AFP levels and AFP non-responders were 'independently associated with poor outcomes after TACE. AFP holds clinical implications for detailed risk stratification upon achieving a CR after TACE. | Lee, Jae Seung; Chon, Young Eun; Kim, Beom Kyung; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Han, Kwang-Hyub; Kang, Wonseok; Choi, Moon Seok; Gwak, Geum-Youn; Paik, Yong-Han; Lee, Joon Hyeok; Koh, Kwang Cheol; Paik, Seung Woon; Kim, Hwi Young; Kim, Tae Hun; Yoo, Kwon; Ha, Yeonjung; Kim, Mi Na; Lee, Joo Ho; Hwang, Seong Gyu; Kim, Soon Sun; Cho, Hyo Jung; Cheong, Jae Youn; Cho, Sung Won; Park, Seung Ha; Heo, Nae-Yun; Hong, Young Mi; Yoon, Ki Tae; Cho, Mong; Park, Jung Gil; Kang, Min Kyu; Park, Soo Young; Kweon, Young Oh; Tak, Won Young; Jang, Se Young; Sinn, Dong Hyun; Kim, Seung Up | Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Seongnam, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, 81 Irwon Ro, Seoul 06351, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Ajou Univ, Sch Med, Dept Gastroenterol, Suwon, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea; Pusan Natl Univ, Yangsan Hosp, Liver Ctr, Yangsan, South Korea; Yeungnam Univ, Med Ctr, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Kim, Yoon/G-6633-2015; Park, Jung/AAK-5167-2020; KIM, JEONGSEON/AAA-4643-2022; Kim, Jung/L-9791-2019; Gwak, Geum/F-4605-2014; Ahn, Sang Hoon/AFM-2603-2022; Kim, Heui-Soo/ABF-3773-2021; Park, Jun/H-7127-2019; Kim, Nayoung/J-5387-2012; Heo, Nae-Yun/LUY-9667-2024; Lee, Joo/AAS-2614-2021; Kim, Yoon/J-2746-2012; Sinn, Dong/JAC-4247-2023; Ha, Yeonjung/AAZ-4724-2021; Kang, Min/U-8050-2018; Kim, Sun/L-4239-2013 | 57204060462; 36089768300; 35302925200; 47861376300; 56119929100; 7401989551; 7402963689; 19640141000; 55661123900; 6506218992; 8423833300; 59454469400; 7202345168; 7102643032; 56493773500; 57125156300; 7202592827; 55948230400; 57202910894; 57193413533; 7404626618; 36056907800; 55338517000; 7004933299; 56454583800; 35171133100; 14022750600; 56405847000; 14820137300; 7401727448; 57216816399; 59142854300; 57191674344; 7004694832; 7004074582; 57202881977; 23493891100; 54933821200 | dh.sinn@samsung.com;ksukorea@yuhs.ac; | YONSEI MEDICAL JOURNAL | YONSEI MED J | 0513-5796 | 1976-2437 | 62 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2021 | 3.052 | 48.0 | 0.8 | 2025-07-30 | 7 | 7 | Carcinoma; hepatocellular; alpha-fetoprotein; prognosis; treatment outcome; transarterial chemoembolization | TUMOR-MARKERS; INVASION; MRECIST; STAGE | Alpha-fetoprotein; Prognosis; Transarterial chemoembolization; Treatment outcome; Carcinoma, hepatocellular | Adult; Aged; alpha-Fetoproteins; Arteries; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Female; Humans; Liver Neoplasms; Male; Middle Aged; Prognosis; Proportional Hazards Models; Recurrence; Treatment Outcome; Venous Thrombosis; alpha fetoprotein; contrast medium; entecavir; alpha fetoprotein; aged; Article; cancer prognosis; cancer recurrence; cancer size; cancer surgery; cancer survival; chemoembolization; computer assisted tomography; female; follow up; gene expression; hepatic portal vein; histology; human; liver cell carcinoma; major clinical study; male; medical record; mortality; nuclear magnetic resonance imaging; outcome assessment; portal vein tumor thrombosis; progression free survival; protein expression; radiofrequency ablation; treatment outcome; treatment response; tumor thrombus; tumor volume; vascular patency; vascularization; adult; adverse event; artery; liver cell carcinoma; liver tumor; metabolism; middle aged; prognosis; proportional hazards model; recurrent disease; vein thrombosis | English | 2021 | 2021-01 | 10.3349/ymj.2021.62.1.12 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Arbuscular mycorrhizal symbiosis: plant growth improvement and induction of resistance under stressful conditions | The impact of stress on crop productivity and the ecosystem have been magnified by climate changes and mispractices in the agriculture field. Soil microbiome is a diverse system consisting of various microorganisms. Environmental control techniques like the use of arbuscular mycorrhizal fungi (AMF) are necessary to enhance crop productivity. AMF is known as stress regulating organisms that help plants within the nutrient uptake, biotic and abiotic stress management, plant protection, and consequently enhancement on crop yields. Also, host plants can tolerate many difficult situations such as water problems, salt stress, heavy metals, and temperature changes through AMF inoculation. Arbuscular mycorrhizae (AM) enhance plant growth under stress by mediating a series of complex contact events between the two symbiotic partners resulting in a good photosynthetic and gas exchange amelioration. Plants have several tolerance mechanisms to deal with the constraints of environmental changes. The antioxidant ability is the principal tolerance mechanism; it is assisted by osmolytes accumulation and exacting absorption of ions. In this review, we will discuss the effect of AMF colonization on the host plants at different stages of growth, with comprehensively updated knowledge, their roles, and applications for plant growth enhancement and mycorrhizae role on plant resistance induction and stress management. | Mitra, Debasis; Djebaili, Rihab; Pellegrini, Marika; Mahakur, Bhaswatimayee; Sarker, Aniruddha; Chaudhary, Priya; Khoshru, Bahman; Del Gallo, Maddalena; Kitouni, Mahmoud; Barik, Durga P.; Panneerselvam, Periyasamy; Das Mohapatra, Pradeep K. | Raiganj Univ, Dept Microbiol, Uttar Dinajpur 733134, W Bengal, India; Univ Bros Mentouri, Lab Microbiol Engn & Applicat, Constantine, Algeria; Univ Aquila, Dept Life Hlth & Environm Sci, Laquila, Italy; Ravenshaw Univ, Dept Bot & Biotechnol, Cuttack, Odisha, India; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu, South Korea; Banasthali Univ, Dept Biosci & Biotechnol, Vanasthali, Rajasthan, India; Univ Tabriz, Dept Soil Biol & Biotechnol, Tabriz, Iran; ICAR Natl Rice Res Inst, Dept Soil Sci & Microbiol, Crop Prod Div, Cuttack 753006, Odisha, India; Raiganj Univ, Prof AK Bothra Environm Conservat Ctr, Uttar Dinajpur, W Bengal, India | Djebaili, Rihab/AAE-4612-2022; Mitra, Debasis/AAP-1925-2020; Pellegrini, Marika/AAA-9802-2020; Chaudhary, Priya/JZC-8108-2024; del Gallo, Maddalena/AAG-1644-2020; Sarker, Aniruddha/GYQ-6800-2022; Khoshru, Bahman/P-8665-2018; Panneerselvam, Periyasamy/AAD-3311-2022 | 57211477848; 57217137548; 57195574945; 57215041699; 57211874397; 57225013823; 57189714397; 6603216241; 56828998100; 8910746200; 16302206400; 59339918700 | panneerccri@rediffmail.com;pkdmvu@gmail.com; | JOURNAL OF PLANT NUTRITION | J PLANT NUTR | 0190-4167 | 1532-4087 | 44 | 13 | SCIE | PLANT SCIENCES | 2021 | 2.277 | 48.3 | 2.65 | 2025-07-30 | 60 | 87 | arbuscular mycorrhizal fungi; biotic and abiotic stress; colonization; plant growth; resistance; stress management | RESPONSES; FUNGI | arbuscular mycorrhizal fungi; biotic and abiotic stress; colonization; plant growth; resistance; stress management | English | 2021 | 2021-08-09 | 10.1080/01904167.2021.1881552 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of sand liquefaction in cyclic triaxial and simple shear tests | The liquefaction resistance and correction factors K-sigma and K-alpha of Nakdong River sand obtained from cyclic triaxial (CTX) tests were compared with those determined by cyclic simple shear (CSS) tests to ascertain the importance of the reduction factor C-r and correction factors K-sigma and K-alpha in liquefaction evaluations, especially in view of the lack of comparative liquefaction assessments based on different laboratory test apparatuses. All samples used for the comparisons were obtained from the same type of sand by using similar preparation methods and they were subjected to similar stress states to minimize the number of factors influencing the comparison results; moreover, the apparatuses used in the two tests were manufactured by the same company and all tests were conducted by a single operator. It was found that the liquefaction resistance in CTX tests was always greater than that in CSS tests. Furthermore, C-r varied from 0.63 to 0.36, and it depended on the relative density D-r and initial static shear ratio alpha. K-sigma, which increased with the normal effective stress sigma(nc)' in CTX tests, was identical to K-sigma observed in CSS tests when alpha was increased up to 0.1. By contrast, K-alpha in the CSS tests was 58%-97% of K-alpha measured in the CTX tests, and it depended on the combined effect of D-r, sigma(nc)', and alpha. The relationship between K-alpha and alpha in both CTX and CSS tests was well represented by a parabolic function. Moreover, the differences in K-alpha values between the CTX and CSS tests were also found to be a parabolic function of alpha. This information can be used for converting CTX (or CSS) values into equivalent CSS (or CTX) values. (C) 2021 Production and hosting by Elsevier B.V. on behalf of The Japanese Geotechnical Society. | Nong, Zhen-Zhen; Park, Sung-Sik; Lee, Dong-Eun | Jiangsu Univ Sci & Technol, Sch Naval Architecture & Ocean Engn, Zhenjiang, Jiangsu, Peoples R China; Kyungpook Natl Univ, Dept Civil Engn, 1370 Sangyeok Dong, Daegu 702701, South Korea; Kyungpook Natl Univ, Dept Architectural Engn, 1370 Sangyeok Dong, Daegu 702701, South Korea | 57211377923; 36241850300; 56605563300 | zznong@foxmail.com;sungpark@knu.ac.kr;dolee@knu.ac.kr; | SOILS AND FOUNDATIONS | SOILS FOUND | 0038-0806 | 61 | 4 | SCIE | ENGINEERING, GEOLOGICAL;GEOSCIENCES, MULTIDISCIPLINARY | 2021 | 3.098 | 48.3 | 2.53 | 2025-07-30 | 41 | 40 | Sand liquefaction; Cyclic triaxial test; Cyclic simple shear test | STRESS; RESISTANCE; BEHAVIOR; SOILS | Cyclic simple shear test; Cyclic triaxial test; Sand liquefaction | Liquefaction; Comparison result; Correction factors; Cyclic simple shear; Liquefaction evaluation; Liquefaction resistance; Parabolic functions; Preparation method; Simple shear test; Chromium | English | 2021 | 2021-08 | 10.1016/j.sandf.2021.05.002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Dietary supplementation with Ceriporia lacerata improves learning and memory in a scopolamine-induced amnesia mouse model | Ceriporia lacerata (CL) is a species of white rot fungi. In this study, we have examined the beneficial effect of CL on scopolamine-induced memory impairment in mice. A freeze-dried CL mycelial culture broth was dissolved and orally administered to scopolamine-treated C57BL/6J mice followed by behavioral tests using the Y-maze, passive avoidance, and Morris water maze tasks. CL administration at a daily dose of 200 mg/kg body weight resulted in restoration of exploration reduction and improvement of associative and spatial learning and memory impairment in scopolamine-treated mice. Concomitantly, heme oxygenase-1 was highly expressed in the hippocampal region of CL-administered mice. Moreover, the ethanolic extract of CL significantly increased the transcriptional activity of antioxidant response element and attenuated the glutamate-induced cytotoxicity in HT22 mouse hippocampal neuronal cells. These findings suggest that the CL intake can confer a beneficial effect on learning and memory presumably through protecting hippocampal neuronal cells from oxidative stress-induced damage. | Lee, Sujin; Lim, Ji Sun; Yun, Hyun Seok; Kim, Yoonsu; Jeong, Soojung; Hwang, Seong Deok; Kim, Jong Won; Oh, Jisun; Kim, Jong-Sang | Kyungpook Natl Univ, Sch Food Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Fugencelltech Co Ltd, Gyeongsangbuk Do 37272, South Korea; Fugenbio Co Ltd, Seoul 06746, South Korea | 57210888405; 57202909530; 57222627199; 57219254485; 57218488343; 57226091282; 57226096573; 56311554100; 37106950100 | drg725@naver.com;lzsunny@daum.net;tkdldjstm011@naver.com;yunsu531@gmail.com;okok9625@naver.com;sd.hwang@fugenbio.co.kr;jongwon.kim@fugenbio.com;j.oh@knu.ac.kr;vision@knu.ac.kr; | FOOD SCIENCE AND BIOTECHNOLOGY | FOOD SCI BIOTECHNOL | 1226-7708 | 2092-6456 | 30 | 8 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 3.231 | 48.3 | 0.49 | 2025-07-30 | 7 | 7 | Ceriporia lacerata; Neuroprotection; Learning and memory; Hippocampal neuron; Heme oxygenase-1 | OXIDATIVE STRESS; CLINICAL-SIGNIFICANCE; ANTIOXIDANT ACTIVITY; ENDOPHYTIC FUNGUS; GUT MICROBIOTA; CELL-DEATH; EXTRACT; GLUTAMATE; MUSHROOMS; DEMENTIA | Ceriporia lacerata; Heme oxygenase-1; Hippocampal neuron; Learning and memory; Neuroprotection | Fungi; Neurons; Porphyrins; Beneficial effects; Ceriporion lacerata; Dietary supplementation; Heme oxygenase-1; Hippocampal neurons; Learning and memory; Mice models; Neuronal cell; Neuroprotection; White rot fungi; Mammals | English | 2021 | 2021-08 | 10.1007/s10068-021-00945-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Microbial inactivation in fresh and minimally processed foods by intense pulsed light (IPL) treatment | The purposes of this study were to evaluate the inactivation effects of intense pulsed light (IPL) on indigenous and inoculated microorganisms in fresh and minimally processed foods and the industrial applicability of this nonthermal sterilization method. The samples were treated with IPL by varying the treatment time and voltage. The inactivation effect tended to increase as the treatment conditions increased. Further, indigenous microorganisms showed a lower inactivation level than inoculated microorganisms, E. coli ATCC 25922, due to the variability of indigenous microorganisms and their properties. Chopped garlic showed a higher E. coli inactivation effect (2.65 log reduction after 0.185 J/cm(2) of IPL) than peeled garlic (1.21 log reduction) due to its larger surface area. The manila clam showed a lower E. coli inactivation (0.93 log reduction) effect than squid (1.84 log reduction) due to its rougher surface. After the IPL treatment, there was no significant difference in temperature, moisture content, and color. | Hwang, Hee-Jeong; Park, Ju-Yeon; Chung, Myong-Soo; Cheigh, Chan-Ick | Dongguk Univ, Res Inst Biotechnol & Med Converged Sci, Goyang 10326, South Korea; Ewha Womans Univ, Dept Food Sci & Engn, Seoul 03760, South Korea; Kyungpook Natl Univ, Dept Food & Food Serv Ind, Sangju 37131, South Korea | ; Park, Ju-Yeon/MYR-6366-2025 | 55855585400; 57226115599; 15057605800; 6506587023 | piatop@hanmail.net;wnwn1995@naver.com;mschung@ewha.ac.kr;cic@knu.ac.kr; | FOOD SCIENCE AND BIOTECHNOLOGY | FOOD SCI BIOTECHNOL | 1226-7708 | 2092-6456 | 30 | 7 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 3.231 | 48.3 | 0.57 | 2025-07-30 | 6 | 9 | Intense pulsed light; Minimally processed food; Indigenous microorganism; Garlic; Manila clam; Squid | ESCHERICHIA-COLI O157-H7; LISTERIA-MONOCYTOGENES; ULTRAVIOLET-LIGHT; UV-LIGHT; DECONTAMINATION; SALMONELLA; EFFICACY; COMBINATION; QUALITY; PRODUCE | Garlic; Indigenous microorganism; Intense pulsed light; Manila clam; Minimally processed food; Squid | Escherichia coli; Molluscs; Processed foods; Shellfish; E.Coli inactivation; Inactivation effect; Intense pulsed light; Log reductions; Microbial inactivation; Minimally processed foods; Treatment conditions; Treatment time; Food microbiology | English | 2021 | 2021-07 | 10.1007/s10068-021-00937-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Mineral-rich Jeju lava sea water suppresses lipid accumulation in 3T3-L1 adipocytes and ameliorates high-fat diet-induced obesity in C57BL/6 J mice | This research aimed to evaluate the potential inhibitory effect of mineral-rich Jeju lava sea water (JLSW) on lipid accumulation. This study optimized the calcium (Ca): magnesium (Mg) ratio (5:1, 2.5:1, 1:1) of JLSW and evaluated the effect on lipid accumulation in 3T3-L1 cells using Oil Red O staining. JLSW with a high Ca:Mg ratio (5:1) suppressed lipid accumulation in 3T3-L1 adipocytes. Based on these in-vitro results, the effects of JLSW on lipid accumulation were investigated in C57BL/6 J mice fed high-fat diets for 14 weeks. Epididymal adipose tissue weight was significantly decreased in mice that received JLSW with a hardness of 800 or 100 mg/L compared to HFD. Adipocyte size was significantly reduced in mice treated with JLSW with a hardness of 20 mg/L in comparison with HFD. Thus, long-term intake of JLSW may be expected to have anti-obesity effects due to the reduction of lipid accumulation. | Hyun, Ye Ji; Kim, Ju Gyeong; Kim, Min Jeong; Jung, Sung Keun; Kim, Ji Yeon | Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, 232 Gongneung Ro, Seoul 01811, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Jung, SUNG KEUN/AGR-2623-2022; Kim, Joo/X-7562-2019; Kim, Yun Hak/ABF-3331-2021 | 57221908866; 57216640718; 57215818497; 35310491400; 55873676800 | yj0706hyun@naver.com;jgrla23@naver.com;minjung8128@gmail.com;skjung04@knu.ac.kr;jiyeonk@seoultech.ac.kr; | FOOD SCIENCE AND BIOTECHNOLOGY | FOOD SCI BIOTECHNOL | 1226-7708 | 2092-6456 | 30 | 2 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 3.231 | 48.3 | 0.41 | 2025-07-30 | 5 | 5 | Jeju lava sea water; Adipogenesis; High-fat diet; Adipocyte size | 3T3-L1; Adipocyte size; Adipogenesis; High-fat diet; Jeju lava sea water | Hardness; Mammals; Nutrition; 3T3-L1 adipocytes; Adipocytes; Adipose tissue; High-fat diet; In-vitro; Inhibitory effect; Lipid accumulations; Oil red o staining; Seawater | English | 2021 | 2021-02 | 10.1007/s10068-020-00859-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prediction of moisture content in steamed and dried purple sweet potato using hyperspectral imaging analysis | Partial least squares regression (PLSR) modeling was performed to predict the moisture content in steamed, dried purple sweet potato based on spectral data obtained from hyperspectral imaging analysis. The PLSR model with a combination of multiplicative scatter correction, Savitzky-Golay, and first derivative exhibited the highest accuracy (R-P(2) = 0.9754). The wavelengths found that strongly affected the PLSR model were 961.12, 1065.50, 1083.93, 1173.23, and 1233.89 nm. These wavelengths were associated with the O-H second overtone and the second overtone of C-H, C-H-2, and C-H-3. When PLSR modeling was performed using these selected wavelengths, the prediction accuracy of the PLSR model exhibited high accuracy (R-P(2) = 0.9521). Therefore, the moisture content could be predicted with high accuracy using only five wavelengths rather than the full spectrum. | Heo, Suhyeon; Choi, Ji-Young; Kim, Jiyoon; Moon, Kwang-Deog | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, 80 Daehak Ro, Daegu 41566, South Korea | 57201391632; 57219113098; 57208110209; 55999192900 | sewt1024@naver.com;chjiyeng91@naver.com;fuocoso95@naver.com;kdmoon@knu.ac.kr; | FOOD SCIENCE AND BIOTECHNOLOGY | FOOD SCI BIOTECHNOL | 1226-7708 | 2092-6456 | 30 | 6 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2021 | 3.231 | 48.3 | 1.55 | 2025-07-30 | 19 | 23 | Hyperspectral imaging analysis; Partial least squares regression modeling; Selected wavelengths; Moisture content; Purple sweet potato | QUALITY; CLASSIFICATION; SPECTROSCOPY; OIL | Hyperspectral imaging analysis; Moisture content; Partial least squares regression modeling; Purple sweet potato; Selected wavelengths | Forecasting; Least squares approximations; Moisture; Moisture determination; Spectroscopy; First derivative; Full spectrum; High-accuracy; Multiplicative scatter correction; Partial least squares regressions (PLSR); Prediction accuracy; Purple sweet potatoes; Spectral data; Hyperspectral imaging | English | 2021 | 2021-06 | 10.1007/s10068-021-00921-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Safety and Effectiveness of an In-Hospital Screening Station for Coronavirus Disease 2019 in Response to the Massive Community Outbreak | Purpose: To evaluate the results of operating an in-hospital coronavirus disease 2019 screening station on an outpatient basis and to identify the effectiveness and necessity of such a screening station. Patients and Methods: This cross-sectional study included 1345 individuals who were tested for COVID-19 using real-time reverse transcription polymerase chain reaction (RTPCR) at an in-hospital screening station on an outpatient basis. The subjects were healthcare workers (HCWs) with suspected COVID-19 symptoms or exposure to patients with confirmed COVID-19, caregivers at the hospital for complete enumeration, and patients who were scheduled to be admitted to a nonrestricted area in the hospital or to visit for outpatient treatment, but had suspected COVID-19 symptoms. The subjects were divided and compared as follows: HCW versus non-HCW groups and RT-PCR positive versus negative groups. Results: A total of 140 had symptoms, 291 wanted to be tested, and 664 were asymptomatic but were screened. Seven subjects had positive results for COVID-19. Compared with the non-HCWs, the HCWs were younger and had a lower rate of underlying medical conditions. In addition, there were more women, individuals with exposure to confirmed cases, and individuals with symptoms or those who just wanted to be tested. The frequency of all symptoms was high among the HCWs. The results of the logistic regression analysis showed that the HCWs were significantly associated with the presence of symptoms, having an odds ratio of 23.317 (confidence interval, 15.142-35.907L; P < 0.001). The positive group had a high rate of exposure to patients with confirmed COVID-19 and had more subjects with symptoms or those who wanted to be tested. Conclusion: In-hospital screening stations are a relatively safe way to protect and support HCWs and to reduce and manage the spread of infection within the hospital effectively during an outbreak in the community. | Choi, Hye-In; Ko, Hae-Jin; Song, Ji-Eun; Park, Ji-Yeon; Kim, Jin-Hee | Kyungpook Natl Univ Hosp, Dept Family Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Family Med, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Chilgok Hosp, Dept Family Med, Daegu, South Korea | ; Song, Jieun/LLM-7026-2024; kim, juhee/HKV-6163-2023 | 57202001023; 54393415700; 57217295366; 57226386288; 57223134282 | liveforme@knu.ac.kr; | RISK MANAGEMENT AND HEALTHCARE POLICY | RISK MANAG HEALTHC P | 1179-1594 | 14 | SCIE;SSCI | HEALTH CARE SCIENCES & SERVICES;HEALTH POLICY & SERVICES | 2021 | 2.853 | 48.3 | 0.21 | 2025-07-30 | 2 | 2 | coronavirus disease 2019; healthcare workers; nocebo effect; hospital infection; screening | RESPIRATORY SYNDROME; WORKERS; INFECTION | Coronavirus disease 2019; Healthcare workers; Hospital infection; Nocebo effect; Screening | adult; age; aged; Article; asymptomatic coronavirus disease 2019; caregiver; controlled study; coronavirus disease 2019; cross-sectional study; epidemic; female; health care personnel; hospital care; human; major clinical study; male; middle aged; nurse; outpatient care; patient safety; real time reverse transcription polymerase chain reaction; retrospective study; screening; young adult | English | 2021 | 2021 | 10.2147/rmhp.s287213 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Short-term wind speed prediction using Extended Kalman filter and machine learning | Wind speed prediction could play an important role in improving the performance of wind turbine control and condition monitoring. For example, by predicting or forecasting the upcoming wind in advance, fluctuations in wind power output in above rated wind speed could be reduced without causing an increase in pitch activity, and anomalies such as an extreme gust could be detected before it reaches the wind turbine, allowing appropriate control actions to take place to minimise any potential damage that could be incurred by the anomalies. A novel wind speed prediction scheme is presented in this paper that comprises mainly two stages, estimation and prediction. Estimation is first carried out using an Extended Kalman filter, which is designed based on a 3 dimensional wind field model and a nonlinear rotor model. Prediction is subsequently performed in two steps, extrapolation and machine learning. The wind speed prediction scheme is tested using data obtained from a high-fidelity aeroelastic model. (C) 2020 The Author(s). Published by Elsevier Ltd. | Hur, Sung-ho | Kyungpook Natl Univ, Sch Elect Engn, Daegu, South Korea | 36455858700 | hur.s.h@ieee.org; | ENERGY REPORTS | ENERGY REP | 2352-4847 | 7 | SCIE | ENERGY & FUELS | 2021 | 4.937 | 48.3 | 3.56 | 2025-07-30 | 59 | 76 | Wind speed prediction; Wind speed estimation; Extended Kalman filter; Neural Network; Wind turbine control | Extended Kalman filter; Neural Network; Wind speed estimation; Wind speed prediction; Wind turbine control | Condition monitoring; Damage detection; Extended Kalman filters; Forecasting; Machine learning; Predictive analytics; Speed; Wind power; Wind turbines; Aeroelastic modeling; Estimation and predictions; Nonlinear rotor models; Rated wind speed; Short-term wind speed predictions; Wind field modeling; Wind speed prediction; Wind turbine control; Wind | English | 2021 | 2021-11 | 10.1016/j.egyr.2020.12.020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Analysis of genomic pathogenesis according to the revised Bethesda guidelines and additional criteria | Purpose As few genotype-phenotype correlations are available for nonsyndromic hereditary colorectal cancer (CRC), we implemented genomic analysis on the basis of the revised Bethesda guideline (RBG) and extended (12 items) to verify possible subtypes. Methods Patients with sporadic CRC (n = 249) were enrolled, stratified according to the revised Bethesda guidelines (RBG+ and RBG- groups) plus additional criteria. Exome/transcriptome analyses (n = 98) and cell-based functional assays were conducted. Results We detected 469 somatic and 830 germline gene mutations differing significantly between the positive and negative groups, associated with 12 RBG items/additional criteria. Twenty-one genes had significantly higher mutation rates in left, relative to right, colon cancer, whileUSP40,HCFC1, andHSPG2mutation rates were higher in rectal than colon cancer.FAT4mutation rates were lower in early-onset CRC, in contrast to increased rates in microsatellite instability (MSI)-positive tumors, potentially defining an early-onset microsatellite-stable subtype. The mutation rates ofCOL6A5andMGAM2were significantly andSETD5was assumably, associated CRC pedigree with concurrent gastric cancer (GC). The predicted deleterious/damaging germline variants,SH2D4Ars35647122, was associated with synchronous/metachronous CRC with related tumors, whileNUP160rs381660 andKRTAP27-1rs2244485 were potentially associated with a GC pedigree and less strictly defined hereditary CRC, respectively.SH2D4AandNUP160acted as oncogenic facilitators. Conclusion Our limited genomic analysis for RBG and additional items suggested that specific somatic alterations in the respective items may enlighten relevant pathogenesis along with the knowledge of germline mutations. Further validation is needed to indicate appropriate surveillance in suspected individuals. | Kim, Jin Cheon; Kim, Jong Hwan; Ha, Ye Jin; Kim, Chan Wook; Tak, Ka Hee; Yoon, Yong Sik; Kwon, Yi Hong; Roh, Seon Ae; Cho, Dong-Hyung; Kim, Seon-Kyu; Kim, Seon-Young; Kim, Yong Sung | Univ Ulsan, Dept Surg, Coll Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Asan Med Ctr, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Univ Ulsan, Inst Innovat Canc Res, Coll Med, Seoul 05505, South Korea; Korea Res Inst Biosci & Biotechnol, Genome Editing Res Ctr, Personalized Genom Med Res Ctr, 52 Eoeun Dong, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea | Kim, Seon-Kyu/KBA-0395-2024; Bin Kim, Hong/J-5452-2012; KIM, SEON HAHN/JTU-1415-2023; Choi, Hye Rin/JDV-9065-2023; Kim, Heui-Soo/ABF-3773-2021; Kim, Seul Kee/A-6076-2015 | 55664401800; 56046884400; 38561431400; 55966571500; 55363346300; 8423860200; 57189294417; 35201933500; 35093684400; 13410554000; 55146733100; 56570975100 | jckim@amc.seoul.kr;kimsy@kribb.re.kr; | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | J CANCER RES CLIN | 0171-5216 | 1432-1335 | 147 | 1 | SCIE | ONCOLOGY | 2021 | 4.322 | 48.4 | 0.41 | 2025-07-30 | 6 | 6 | Hereditary colorectal cancer; Revised Bethesda guideline; Nonsyndromic; NGS; SNP | NONPOLYPOSIS COLORECTAL-CANCER; MICROSATELLITE INSTABILITY; LYNCH-SYNDROME; SPECTRUM; PART | Hereditary colorectal cancer; NGS; Nonsyndromic; Revised Bethesda guideline; SNP | Biomarkers, Tumor; Colorectal Neoplasms; Genetic Testing; High-Throughput Nucleotide Sequencing; Humans; Microsatellite Instability; Mutation; Prognosis; ankk1 protein; anks1a protein; beclin 1; bmpr2 protein; c2orf16 protein; cacna1d protein; calcium release activated calcium channel 1; ccdc122 protein; cdh10 protein; cenpt protein; cnot1 protein; complementary DNA; ctbp2 protein; dclk1 protein; dgkh protein; dlgap5 protein; dnhd1 protein; dst protein; elmo3 protein; ephrin receptor A3; epidermal growth factor receptor 4; erich3 protein; fat1 protein; fat4 protein; frem2 protein; fscn3 protein; golgb1 protein; hcfc1 protein; helz2 protein; high mobility group A protein; ino80 protein; K ras protein; kazn protein; krt76 protein; krtap27 1 protein; lc3 protein; lrrc7 protein; matrix metalloproteinase; matrix metalloproteinase 27; megf8 protein; messenger RNA; ms4a14 protein; muc12; muc16 protein; MutL protein homolog 1; nerve cell adhesion molecule; nup160 protein; oncoprotein; or5a2 protein; pcdh17 protein; pcdh19 protein; pericentrin; perlecan; prdm2 protein; protein MSH3; ptprq protein; rbbp8 protein; retinoblastoma binding protein 2; rev3l protein; rims2 protein; scaf4 protein; sec31a protein; setd5 protein; sh2d4a protein; si protein; siglec12 protein; slc8a1 protein; spta1 protein; syne1 protein; tas2r4 protein; thsd7a protein; top2b protein; transcriptome; trio protein; ttn protein; ubr5 protein; unc79 protein; unclassified drug; usp40 protein; uvomorulin; vimentin; vps13c protein; wars2 protein; xpot protein; zc3h13 protein; znf366 protein; tumor marker; adult; Article; cell proliferation; clinical feature; cohort analysis; colon cancer; colon carcinogenesis; copy number variation; DNA content; DNA sequencing; early cancer; epithelial mesenchymal transition; exome; family history; first-degree relative; gene expression level; gene frequency; gene overexpression; genome analysis; genotype phenotype correlation; germline mutation; hereditary colorectal cancer; hereditary nonpolyposis colorectal cancer; high throughput sequencing; human; human cell; human tissue; immunohistochemistry; major clinical study; microsatellite instability; middle aged; mismatch repair; molecular pathology; mRNA expression level; pedigree; practice guideline; priority journal; promoter region; RNA sequencing; second-degree relative; single nucleotide polymorphism; somatic mutation; stomach cancer; transcriptomics; tumor associated leukocyte; colorectal tumor; genetic screening; genetics; microsatellite instability; mutation; pathology; procedures; prognosis | English | 2021 | 2021-01 | 10.1007/s00432-020-03391-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Real-world outcomes of anti-PD1 antibodies in platinum-refractory, PD-L1-positive recurrent and/or metastatic non-small cell lung cancer, and its potential practical predictors: first report from Korean Cancer Study Group LU19-05 | Purpose Although immune-checkpoint inhibitors have become a new therapeutic option for recurrent/metastatic non-small cell lung cancers (R/M-NSCLC), its clinical benefit in the real-world is still unclear. Methods We investigated 1181 Korean patients with programmed death-1 ligand 1 (PD-L1)-positive [tumor proportion score (TPS) >= 10% by the SP263 assay or >= 50% by the 22C3 assay] R/M-NSCLC treated with pembrolizumab or nivolumab after failure of platinum-based chemotherapy. Results The median age was 67 years, 13% of patients had ECOG-PS >= 2, and 27% were never-smokers. Adenocarcinoma was predominant (61%) and 18.1% harbored an EGFR activating mutation or ALK rearrangement. Pembrolizumab and nivolumab were administered to 51.3% and 48.7, respectively, and 42% received them beyond the third-line chemotherapy. Objective response rate (ORR) was 28.6%. Pembrolizumab group showed numerically higher ORR (30.7%) than the nivolumab group (26.4%), but it was comparable with that of the nivolumab group having PD-L1 TPS >= 50% (32.4%). Median progression-free survival (PFS) and overall survival (OS) were 2.9 (95% CI 0-27.9) and 10.7 months (95% CI 0-28.2), respectively. In multivariable analysis, concordance of TPS >= 50% in both PD-L1 assays and the development of immune-related adverse events (irAEs) were two significant predictors of better ORR, PFS, and OS. EGFR mutation could also predict significantly worse OS outcomes. Conclusion The real-world benefit of later-line anti-PD1 antibodies was comparable to clinical trials in patients with R/M-NSCLC, although patients generally were more heavily pretreated and had poorer ECOG-PS. Concordantly high PD-L1 TPS >= 50% and development of irAE could independently predict better treatment outcomes, while EGFR mutation negatively affected OS. | Park, Ji Hyun; You, Gun Lyung; Ahn, Myung-Ju; Kim, Sang-We; Hong, Min Hee; Han, Ji-Youn; Ock, Chan-Young; Lee, Jong-Seok; Oh, In Jae; Lee, Shin Yup; Kim, Cheol Hyeon; Min, Young Joo; Choi, Yoon Hee; Ryu, Jeong-Seon; Park, Sun Hyo; Ahn, Hee Kyung; Shim, Byoung-Yong; Lee, Ki Hyeong; Lee, Sung Yong; Kim, Jin-Soo; Yi, Jiun; Choi, Su Kyung; An, Hyonggin; Kang, Jin Hyoung | Univ Konkuk, Coll Med, Konkuk Med Ctr, Dept Hematooncol, Seoul, South Korea; Korea Univ, Dept Biostat, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Med Oncol, Seoul, South Korea; Yonsei Univ, Coll Med, Yonsei Canc Ctr, Dept Internal Med, Seoul, South Korea; Natl Canc Ctr, Res Inst & Hosp, Ctr Lung Canc, Goyang, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Chonnam Natl Univ, Dept Internal Med, Hwasun Hosp, Gwangju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Korea Canc Ctr Hosp, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Internal Med, Ulsan, South Korea; Dongnam Inst Radiol & Med Sci, Busan, South Korea; Inha Univ Hosp, Dept Internal Med, Incheon, South Korea; Keimyung Univ, Dept Internal Med, Dongsan Hosp, Daegu, South Korea; Gachon Univ, Gil Med Ctr, Coll Med, Incheon, South Korea; Catholic Univ Korea, St Vincent Hosp, Dept Med Oncol, Suwon, South Korea; Chungbuk Natl Univ, Div Med Oncol, Dept Med, Coll Med, Cheongju, South Korea; Korea Univ, Dept Internal Med, Guro Hosp, Seoul, South Korea; Seoul Natl Univ, Boramae Med Ctr, Seoul Metropolitan Govt, Dept Internal Med, Seoul, South Korea; Hlth Insurance Review & Assessment Pharmaceut Ben, Wonju, South Korea; Catholic Univ, Seoul St Marys Hosp, Dept Med Oncol, 222 Banpo Daero, Seoul 06591, South Korea | Lee, Hyoungjin/GRR-7154-2022; Kang, Jin Hyoung/KYQ-2256-2024; Kim, Tae-Hee/AAN-9079-2021; Oh, In-Jae/AAG-5919-2020; Park, Sun Hyo/JVN-6216-2024; Kim, Jin-Soo/AAF-3359-2019; choi, Yoon/AAK-5172-2021; Kim, Sanghoon/ABA-6994-2020 | 56648383500; 57221761353; 7103352186; 49061131600; 57211695522; 18042023400; 36667082500; 8622005400; 58754601500; 49863712700; 57223021245; 7202197178; 34879646000; 7401868634; 57191525804; 50261094700; 8086955700; 57196253114; 56734650000; 57049824000; 57221763530; 57221763311; 7202277445; 56656852000 | oncologykang@naver.com; | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | J CANCER RES CLIN | 0171-5216 | 1432-1335 | 147 | 8 | SCIE | ONCOLOGY | 2021 | 4.322 | 48.4 | 0.41 | 2025-07-30 | 8 | 6 | Immune-checkpoint inhibitor; Non-small cell lung cancer; Real-world; Biomarkers; PD-L1; irAE | Biomarkers; Immune-checkpoint inhibitor; irAE; Non-small cell lung cancer; PD-L1; Real-world | Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Cisplatin; Drug Resistance, Neoplasm; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nivolumab; Prognosis; Programmed Cell Death 1 Receptor; Republic of Korea; Survival Analysis; Treatment Outcome; anaplastic lymphoma kinase; antineoplastic metal complex; corticosteroid; epidermal growth factor receptor; nivolumab; pembrolizumab; programmed death 1 ligand 1; CD274 protein, human; cisplatin; immunological antineoplastic agent; monoclonal antibody; nivolumab; PDCD1 protein, human; pembrolizumab; programmed death 1 ligand 1; programmed death 1 receptor; adult; aged; Article; asthenia; cancer growth; cancer immunotherapy; cancer recurrence; cancer resistance; cancer survival; chemoradiotherapy; clinical outcome; corticosteroid therapy; diarrhea; drug efficacy; drug safety; drug withdrawal; dyspnea; eczema; EGFR signaling; fatigue; female; gene mutation; gene rearrangement; hepatitis; human; human cell; hypothyroidism; immunopathology; Korean (people); lung adenocarcinoma; major clinical study; male; multicenter study; never smoker; non small cell lung cancer; overall survival; pneumonia; progression free survival; pruritus; psoriasis; rash; retrospective study; skin disease; smoking; squamous cell lung carcinoma; treatment response; treatment response time; ulcerative colitis; diagnosis; drug effect; drug resistance; epidemiology; genetics; immunology; lung tumor; metabolism; metastasis; middle aged; mortality; non small cell lung cancer; pathology; prognosis; South Korea; survival analysis; treatment outcome; tumor recurrence; very elderly | English | 2021 | 2021-08 | 10.1007/s00432-021-03527-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Complete 3D Foot Scanning System Using 360 Degree Rotational and Translational Laser Triangulation Sensors | This paper proposes a new type of 3D foot scanning system using rotational and translational 3D scanning stages. Commercial 3D foot scanning systems (or scanners) mostly employ the laser triangulation method and three or more linear stages to scan the entire 3D shape of the foot. We introduce a new foot scanning method using only two laser-camera triangulation sensors. The proposed scanning system consists of a 360 degrees rotational and a linear translational 3D sensors. The rotational sensor employs two line lasers with a vision camera to solve an occlusion problem of the rotational stage and acquires the 3D shape of the upper part of the foot. The translational sensor consists of a line laser and a vision camera and acquires the 3D shape of the foot sole. The performance of the proposed scanning technique is verified using plastic models and human feet. In average, about 0.5 mm reconstruction accuracy is obtained by the proposed technique. | Lee, Ju-hwan; Lee, Min-jae; Park, Soon-Yong | Kyungpook Natl Univ, Sch Comp Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea | Park, Soon-Yong/HGV-2374-2022 | 57193725457; 57201267778; 7501834063 | sasinhwan@naver.com;suddenly90@naver.com;sypark@knu.ac.kr; | INTERNATIONAL JOURNAL OF CONTROL AUTOMATION AND SYSTEMS | INT J CONTROL AUTOM | 1598-6446 | 2005-4092 | 19 | 9 | SCIE | AUTOMATION & CONTROL SYSTEMS | 2021 | 2.964 | 48.5 | 0.83 | 2025-07-30 | 9 | 13 | Laser triangulation; rotating-type 3D sensor; sensor calibration; 3D foot scanner; 3D reconstruction | CALIBRATION | 3D foot scanner; 3D reconstruction; Laser triangulation; rotating-type 3D sensor; sensor calibration | Cameras; Imaging systems; Triangulation; Laser triangulation method; Laser triangulation sensor; Occlusion problems; Plastic models; Reconstruction accuracy; Scanning methods; Scanning systems; Scanning techniques; Scanning | English | 2021 | 2021-09 | 10.1007/s12555-020-0147-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Crystal growth and characterization of K2LiCeCl6, a novel elpasolite scintillator | This study reports on the crystal growth, luminescence, and scintillation performance of a novel elpasolite K2LiCeCl6 scintillator. The single crystal of this material was grown by the two-zone vertical Bridgman technique. The luminescence and scintillation performance were studied under X-, gamma-rays, and alpha-particles excitation at room temperature. The fast scintillation response and alpha-particles and gamma-ray separation capability reveal that this scintillator can be used as a dual-mode gamma-rays and thermal neutron detector. | Cho, J. Y.; Kim, H. J.; Khan, Arshad; Park, J. M. | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongup 56212, South Korea | Kim, Hong Joo/AAE-1178-2022 | 57204422573; 59051568100; 56017063700; 9942606600 | jmp1024@kaeri.re.kr;jmp1024@kaeri.re; | RADIATION MEASUREMENTS | RADIAT MEAS | 1350-4487 | 1879-0925 | 141 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2021 | 1.743 | 48.5 | 0.21 | 2025-07-30 | 0 | 3 | K2LiCeCl6; Elpasolite; Luminescence; Scintillation; Pulse shape discrimination | PULSE-SHAPE DISCRIMINATION; NEUTRON; LIQUID; CE3+ | Elpasolite; K<sub>2</sub>LiCeCl<sub>6</sub>; Luminescence; Pulse shape discrimination; Scintillation | Alpha particles; Cerium compounds; Chlorine compounds; Crystal growth; Crystallization; Gamma rays; Lithium compounds; Scintillation; Scintillation counters; Single crystals; Dual modes; Elpasolite; Scintillation performance; Scintillation response; Thermal neutron detectors; Vertical Bridgman technique; Potassium compounds | English | 2021 | 2021-02 | 10.1016/j.radmeas.2021.106524 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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