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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Mycophenolic Acid Trough Concentration and Dose Are Associated with Hematologic Abnormalities but Not Rejection in Kidney Transplant Recipients | Background: Little is known regarding the safe fixed dose of mycophenolic acid (MPA) for preventing biopsy-proven acute rejection (BPAR) in kidney transplant recipients (KTRs). We investigated the correlation of MPA trough concentration (MPA C-0 ) and dose with renal transplant outcomes and adverse events. Methods: This study included 79 consecutive KTRs who received MPA with tacrolimus (TAC) and corticosteroids. The MPA C-0 of all the enrolled KTRs was measured, which was determined monthly by using particle-enhanced turbidimetric inhibition immunoassay for 12 months, and clinical data were collected at each time point. The clinical endpoints included BPAR, any cytopenia, and BK or cytomegalovirus infections. Results: No differences in MPA C-0 and dose were observed between KTRs with or without BPAR or viral infections under statistically comparable TAC concentrations. MPA C-0 was significantly higher in patients with leukopenia (P = 0.021) and anemia (P = 0.002) compared with those without cytopenia. The MPA dose was significantly higher in patients with thrombocytopenia (P = 0.002) compared with those without thrombocytopenia. MPA C-0 >= 3.5 mu g/mL was an independent risk factor for leukopenia (adjusted odds ratio [AOR], 3.80; 95% confidence interval [CI], 1.24-11.64; P = 0.019) and anemia (AOR, 5.90; 95% CI, 1.27-27.51; P = 0.024). An MPA dose greater than the mean value of 1,188.8 mg/day was an independent risk factor for thrombocytopenia (AOR, 3.83; 95% CI, 1.15-12.78; P = 0.029). However, an MPA dose less than the mean value of 1,137.3 mg/day did not increase the risk of BPAR. Conclusion: Either a higher MPA C-0 or dose is associated with an increased risk of cytopenia, but neither a lower MPA C-0 nor dose is associated with BPAR within the first year of transplantation. Hence, a reduced MPA dose with TAC and corticosteroids might be safe in terms of reducing hematologic abnormalities without causing rejection. | Jung, Hee-Yeon; Lee, Sukyung; Jeon, Yena; Choi, Ji-Young; Cho, Jang-Hee; Park, Sun-Hee; Kim, Yong-Lim; Kim, Hyung-Kee; Huh, Seung; Won, Dong Il; Kim, Chan-Duck | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Pohang St Marys Hosp, Dept Internal Med, Pohang, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Stat, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Clin Pathol, Daegu, South Korea | ; Jung, Hee-Yeon/AFB-8578-2022; Kim, Hyung-Kee/JBR-8125-2023; Kim, Yong-Lim/AGK-3172-2022; Cho, Jang-hee/ABD-3534-2020 | 57196396467; 57202883548; 57209909350; 7501393222; 7403536291; 7501831741; 55633533600; 35169819900; 7101832929; 57217128608; 8558530700 | drcdkim@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 24 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 0.4 | 2025-06-25 | 6 | 8 | Mycophenolic Acid; Kidney Transplantation; Drug Monitoring; Dose; Graft Rejection | AFRICAN-AMERICAN; MOFETIL; PHARMACOKINETICS; TACROLIMUS; PHARMACODYNAMICS; EFFICACY; EVENTS; SODIUM; SAFETY; GRAFT | Dose; Drug monitoring; Graft rejection; Kidney transplantation; Mycophenolic acid | Adrenal Cortex Hormones; Adult; Anemia; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Graft Rejection; Hematologic Diseases; Humans; Immunosuppressive Agents; Kidney Transplantation; Leukopenia; Logistic Models; Male; Middle Aged; Mycophenolic Acid; Odds Ratio; Risk Factors; Tacrolimus; Thrombocytopenia; corticosteroid; immunosuppressive agent; mycophenolic acid; tacrolimus; adult; adverse event; anemia; combination drug therapy; dose response; female; graft rejection; hematologic disease; human; kidney transplantation; leukopenia; male; middle aged; odds ratio; risk factor; statistical model; thrombocytopenia | English | 2020 | 2020-06-22 | 10.3346/jkms.2020.35.e185 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Olfactory and Gustatory Dysfunction in a COVID-19 Patient with Ankylosing Spondylitis Treated with Etanercept: Case Report | The neurologic manifestations concerning coronavirus disease 2019 (COVID-19) are highly penetrated. Anosmia and ageusia are one of the common acute neurologic symptoms, which develop in the early stage of COVID-19. However, it is not reported that how immunosuppressive agents affect these symptoms. We report olfactory and gustatory dysfunctions in a patient with ankylosing spondylitis (AS) treated with etanercept during COVID-19. A 53-year-old female showing AS controlled with tumor necrosis factor-alpha inhibitor, etanercept, had been diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, presenting cough and rhinorrhea. One month after diagnosis, she complained about hyposmia and hypogeusia two days before the seronegative conversion of SARS-CoV-2, which were confirmed by a neurological examination. We speculate that the etanercept may have delayed the development of olfactory and gustatory dysfunction in the patient. | Lee, Jong-Mok; Lee, Sang Jin | Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Rheumatol, Daegu, South Korea; Kyungpook Natl Univ, Dept Internal Med, Div Rheumatol, 130 Dongdeok Ro, Daegu 41944, South Korea | Lee, Jong-Mok/KVY-9550-2024 | 57192075673; 57192516055 | dream1331@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 21 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 1.19 | 2025-06-25 | 17 | 15 | Severe Acute Respiratory Syndrome Coronavirus 2; Tumor Necrosis Factor-alpha; Neurologic Manifestations | Neurologic manifestations; Severe acute respiratory syndrome coronavirus 2; Tumor necrosis factor-alpha | Betacoronavirus; Coronavirus Infections; Etanercept; Female; Humans; Middle Aged; Olfaction Disorders; Pandemics; Pneumonia, Viral; Spondylitis, Ankylosing; Taste Disorders; etanercept; ankylosing spondylitis; Betacoronavirus; case report; complication; coronavirus disease 2019; Coronavirus infection; female; human; middle aged; pandemic; Severe acute respiratory syndrome coronavirus 2; smelling disorder; taste disorder; virus pneumonia | English | 2020 | 2020-06-01 | 10.3346/jkms.2020.35.e201 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Potential Utility of Therapeutic Drug Monitoring of Adalimumab in Predicting Short-Term Mucosal Healing and Histologic Remission in Pediatric Crohn's Disease Patients | Background: Limited data exist regarding mucosal healing (MH) and therapeutic drug monitoring (TDM) in pediatric Crohn's disease (CD) patients treated with adalimumab (ADL). We aimed to investigate the associations between ADL trough levels (TLs) and MH, and between ADL TLs and histologic remission (HR) at 16 weeks from ADL treatment in pediatric CD patients. Methods: This was a prospective study on moderate-to-severe lumina! pediatric CD patients receiving ADL. Ileocolonoscopies and biopsies, as well as clinical activity assessments, laboratory examinations, including tests for ADL TLs and antibody to ADL, were performed 16 weeks after ADL initiation. MH was defined as a Simple Endoscopic Score for CD of 0. HR was defined as the complete absence of microscopic inflammation. Results: Seventeen subjects (13 males, 4 females) were included. At 16 weeks from ADL initiation, 14 (82.4%), 8 (47.1%), and 4 (23.5%) patients achieved clinical remission, MH, and HR, respectively. ADL TLs were significantly higher in patients who achieved MH compared to those who did not (13.0 +/- 6.5 vs. 6.2 +/- 2.6 mu g/mL, respectively; P= 0.023) and also significantly higher in patients who achieved HR compared to those who did not (17.9 +/- 5.3 vs. 6.8 +/- 2.5 mu g/mL, respectively; P= 0.02). The optimal TL for predicting MH was 8.76 mu g/mL. Conclusion: Serum ADL TLs at 16 weeks were significantly higher in pediatric patients with CD who achieved MH and HR, respectively. TDM may guide in optimizing treatment efficacy and better target MH in the era of treat-to-target. | Choi, So Yoon; Choi, Young Ok; Choe, Yon Ho; Kang, Ben | Inje Univ, Haeundae Paik Hosp, Dept Pediat, Coll Med, Busan, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pediat, 81 Irwon Ro, Seoul 06351, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, 680 Gukchaebosang Ro, Daegu 41944, South Korea | ; 康, 奔/JMQ-0812-2023 | 57207282105; 57202305551; 21333712100; 57194823199 | yonho.choe@samsung.com;benkang@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 16 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 0.96 | 2025-06-25 | 14 | 13 | Therapeutic Drug Monitoring; Mucosal Healing; Adalimumab | INFLAMMATORY-BOWEL-DISEASE; MAINTENANCE TREATMENT; INFLIXIMAB; EFFICACY; PHARMACOKINETICS; ASSOCIATION; COMBINATION; VALIDATION; DIAGNOSIS; CHILDREN | Adalimumab; Mucosal healing; Therapeutic drug monitoring | Adalimumab; Adolescent; Area Under Curve; Child; Crohn Disease; Drug Monitoring; Female; Humans; Intestinal Mucosa; Male; Prospective Studies; ROC Curve; Severity of Illness Index; Treatment Outcome; Wound Healing; adalimumab; adolescent; area under the curve; child; Crohn disease; drug monitoring; female; human; intestine mucosa; male; pathology; procedures; prospective study; receiver operating characteristic; severity of illness index; treatment outcome; wound healing | English | 2020 | 2020-04-27 | 10.3346/jkms.2020.35.e114 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Pregnancy and Epilepsy: a Korean Tertiary Epilepsy Center Review | Background: Pregnancy in women with epilepsy (WWE) is known to have a higher risk for fetal development complications, which may include congenital malformations. Unfortunately, information pertaining to pregnancy in WWE is difficult to obtain because there are considerable ethical issues preventing these studies from being conducted on pregnant women. Therefore, this study investigated the pregnancies of Korean WWE in a tertiary epilepsy center to observe data resulting from the outcome of the pregnancies. Methods: This was a retrospective study of 48 pregnant WWE who were treated at the regional tertiary epilepsy center. All records of hospital visits before and after the period of pregnancy were analyzed to obtain information about the seizures as well as pregnancy-related outcomes, including the status of the newborns' conditions. Results: The subject group consisted of 31 (63.3%) with partial epilepsy, 6 (12.5%) with generalized epilepsy, and 11 (22.9%) with unclassified epilepsy. There were 27 subjects who took one antiepileptic drug (AEU), and 12 who took two AEDs. The most commonly used drug was lamotrigine (29.8%). Of the 48 WWE involved in the study, 31 underwent caesarian sections and 17 opted for natural birth. Thirty-nine (81.3%) delivered at full-term, but 9 (18.7%) delivered at preterm. Compared to full-term infants, pre-mature infants showed lower birth weight, smaller head circumference, shorter height, and lower 1-minute Apgar scores, but seizure frequencies of the mothers did not differ. Conclusion: In WWE, epilepsy classification, number of AEDs taken, and frequency of seizures are not significantly correlated with delivery and fetal condition. This data could be used as a clinical reference for physicians to provide useful information to WWE if they are concerned about their pregnancies. | Jeon, Ji-Ye; Bae, Jin Gon; Kim, Keun Tae; Cho, Yong Won | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Obstet & Gynecol, Sch Med, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurol, Sch Med, 1095 Dalgubeol Daero, Daegu 42601, South Korea | Kim, Keun Tae/IQU-1105-2023 | 57194943660; 57215844401; 57204465615; 55080335000 | neurocho@gmail.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 19 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 0.16 | 2025-06-25 | 3 | 4 | Pregnancy; Epilepsy; Antiepileptic Drugs | SEIZURE CONTROL; WOMEN | Antiepileptic drugs; Epilepsy; Pregnancy | Adult; Anticonvulsants; Cesarean Section; Electroencephalography; Epilepsy; Female; Gestational Age; Head; Humans; Infant, Low Birth Weight; Infant, Newborn; Lamotrigine; Pregnancy; Pregnancy Outcome; Premature Birth; Republic of Korea; Retrospective Studies; Severity of Illness Index; anticonvulsive agent; lamotrigine; adult; cesarean section; electroencephalography; epilepsy; female; gestational age; head; human; low birth weight; newborn; pathology; physiology; pregnancy; pregnancy outcome; prematurity; retrospective study; severity of illness index; South Korea | English | 2020 | 2020-05-18 | 10.3346/jkms.2020.35.e119 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients | Initially, acute loss of smell (anosmia) and taste (ageusia) was not considered important symptoms for coronavirus disease 2019 (COVID-19). To determine the prevalence of these symptoms and to evaluate their diagnostic significance, we (approximately 150 physicians of the Daegu Medical Association) prospectively collected data of cases of anosmia and ageusia from March 8, 2020, via telephone interview among 3,191 patients in Daegu, Korea. Acute anosmia or ageusia was observed in 15.3%(488/3,191) patients in the early stage of COVID-19 and in 15.7% (367/2,342) patients with asymptomatic-to-mild disease severity. Their prevalence was significantly more common among females and younger individuals (P= 0.01 and P< 0.001, respectively). Most patients with anosmia or ageusia recovered within 3 weeks. The median time to recovery was 7 days for both symptoms. Anosmia and ageusia seem to be part of important symptoms and clues for the diagnosis of COVID-19, particularly in the early stage of the disease. | Lee, Yonghyun; Min, Pokkee; Lee, Seonggu; Kim, Shin-Woo | Daegu Med Assoc, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea | Kim, Sooyeon/AAA-8521-2022 | 57216729192; 57216726622; 57216732146; 8710731500 | ksw2kms@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 18 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 28.5 | 2025-06-25 | 338 | 395 | Loss of Smell; Anosmia; Loss of Taste; Ageusia; COVID-19 | Ageusia; Anosmia; COVID-19; Loss of smell; Loss of taste | Adult; Age Distribution; Ageusia; Betacoronavirus; Clinical Laboratory Techniques; Coronavirus; Coronavirus Infections; Female; Humans; Male; Olfaction Disorders; Pandemics; Pneumonia, Viral; Polymerase Chain Reaction; Prevalence; Republic of Korea; Sex Distribution; Smell; Taste; adult; age distribution; ageusia; Betacoronavirus; complication; Coronavirinae; coronavirus disease 2019; Coronavirus infection; female; genetics; human; isolation and purification; laboratory technique; male; odor; pandemic; polymerase chain reaction; prevalence; Severe acute respiratory syndrome coronavirus 2; sex ratio; smelling disorder; South Korea; taste; virus pneumonia | English | 2020 | 2020-05-11 | 10.3346/jkms.2020.35.e174 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Psychosocial Support during the COVID-19 Outbreak in Korea: Activities of Multidisciplinary Mental Health Professionals | As of April 18, 2020, there have been a total of 10,653 confirmed cases and 232 deaths due to coronavirus disease 2019 (COVID-19) in Korea. The pathogen spread quickly, and the outbreak caused nationwide anxiety and shock. This study presented the anecdotal records that provided a detailed process of the multidisciplinary teamwork in mental health during the COVID-19 outbreak in the country. Psychosocial support is no less important than infection control during an epidemic, and collaboration and networking are at the core of disaster management. Thus, a multidisciplinary team of mental health professionals was immediately established and has collaborated effectively with its internal and external stakeholders for psychosocial support during the COVID-19 outbreak. | Hyun, Jinhee; You, Sungeun; Sohn, Sunju; Kim, Seok-Joo; Bae, Jeongyee; Baik, Myungjae; Cho, In Hee; Choi, Hyunjung; Choi, Kyeong-Sook; Chung, Chan-Seung; Jeong, Chanyoung; Joo, Hyesun; Kim, Eunji; Kim, Heeguk; Kim, Hyun Soo; Ko, Jinsun; Lee, Jung Hyun; Lee, Sang Min; Lee, So Hee; Chung, Un Sun | Daegu Univ, Dept Social Welf, Coll Social Sci, Gyongsan, South Korea; Chungbuk Natl Univ, Dept Psychol, Coll Social Sci, Cheongju, South Korea; Cheongju Univ, Dept Social Welf, Coll Humanities & Social Sci, Cheongju, South Korea; Inje Univ, Sch Nursing, Busan, South Korea; Armed Forces Capital Hosp, Mental Hlth Ctr, Seongnam, South Korea; WIM Psychiat Clin, Dept Psychiat, Seongnam, South Korea; Eulji Univ, Dept Neuropsychiat, Sch Med, Daejeon, South Korea; Maum Dream Clin, Dept Psychiat, Seoul, South Korea; Saemirae Hosp, Dept Psychiat, Gwangju, South Korea; Korea Trauma Res & Educ Inst, Seoul, South Korea; MaumToDoc Psychiat Clin, Ansan, South Korea; Sangji Univ, Coll Humanities & Social Sci, Dept Social Welf, Wonju, South Korea; Myongji Hosp, Dept Psychiat, Goyang, South Korea; Our Neighborhood Mental Hlth Res Inst, Seoul, South Korea; Natl Ctr Mental Hlth, Natl Ctr Disaster Trauma, Seoul, South Korea; Kyung Hee Univ Hosp, Dept Psychiat, Seoul, South Korea; Natl Med Ctr, Dept Psychiat, Seoul, South Korea; Kyungpook Natl Univ, Dept Psychiat, Childrens Hosp, 807 Hoguk Ro, Daegu 41404, South Korea | ; Lee, Heewoo/AAN-4968-2020; Lee, So Hee/B-5940-2016; Lee, Sang Min/ABH-6121-2020; Chung, Chan-Seung/AAT-3048-2021 | 57217111296; 23988271500; 22935798400; 57217113122; 23494910300; 57200520126; 57217111809; 57217112788; 55217204300; 57217111374; 57217112666; 57217112281; 57196153776; 57217112203; 57204359154; 57217112725; 55512320600; 57194189841; 56442744300; 24477437300 | unsunchung@gmail.com; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 22 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 2.31 | 2025-06-25 | 38 | 35 | COVID-19; Psychosocial Support; Multidisciplinary; Mental Health; Disaster | COVID-19; Disaster; Mental health; Multidisciplinary; Psychosocial support | Betacoronavirus; Coronavirus Infections; Health Personnel; Humans; Interprofessional Relations; Mental Health; Pandemics; Pneumonia, Viral; Psychosocial Support Systems; Republic of Korea; Betacoronavirus; coronavirus disease 2019; Coronavirus infection; health care personnel; human; mental health; pandemic; psychology; psychosocial care; public relations; South Korea; virus pneumonia | English | 2020 | 2020-06-08 | 10.3346/jkms.2020.35.e211 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Revised Triage and Surveillance Protocols for Temporary Emergency Department Closures in Tertiary Hospitals as a Response to COVID-19 Crisis in Daegu Metropolitan City | Background: When an emergency-care patient is diagnosed with an emerging infectious disease, hospitals in Korea may temporarily close their emergency departments (Ells) to prevent nosocomial transmission. Since February 2020, multiple, consecutive Ell closures have occurred due to the coronavirus disease 2019 (COVID-19) crisis in llaegu. However, sudden Ell closures are in contravention of laws for the provision of emergency medical care that enable the public to avail prompt, appropriate, and 24-hour emergency medical care. Therefore, this study ascertained the vulnerability of the ED at tertiary hospitals in Daegu with regard to the current standards. A revised triage and surveillance protocol has been proposed to tackle the current crisis. Methods: This study was retrospectively conducted at 6 level 1 or 2 EDs in a metropolitan city where ED closure due to COVID-19 occurred from February 18 to March 26, 2020. The present status of ED closure and patient characteristics and findings from chest radiography and laboratory investigations were assessed. Based on the experience from repeated Ell closures and the modified systems that are currently used in Ells, revised triage and surveillance protocols have been developed and proposed. Results: During the study period, 6 level 1 or 2 emergency rooms included in the study were shut down 27 times for 769 hours. Thirty-one confirmed COVID-19 cases, of whom 7 died, were associated with the incidence of ED closure. Typical patient presentation with respiratory symptoms of COVID-19 was seen in less than 50% of patients, whereas abnormal findings on chest imaging investigations were detected in 93.5% of the study population. The chest radiography facility, resuscitation rooms, and triage area were moved to locations outside the ED, and a new surveillance protocol was applied to determine the factors warranting quarantine, including symptoms, chest radiographic findings, and exposure to a source of infection. The incidence of Ell closures decreased after the implementation of the revised triage and surveillance protocols. Conclusion: Triage screening by emergency physicians and surveillance protocols with an externally located chest imaging facility were effective in the early isolation of COVID-19 patients. In future outbreaks of emerging infectious diseases, efforts should be focused toward the provision of continued Ell treatment with the implementation of revised triage and surveillance protocols. | Chung, Han Sol; Lee, Dong Eun; Kim, Jong Kun; Yeo, In Hwan; Kim, Changho; Park, Jungbae; Seo, Kang Suk; Park, Sin-Yul; Kim, Jung Ho; Kim, Gyunmoo; Lee, Suk Hee; Cheon, Jeon Jae; Kim, Yang Hun | Kyungpook Natl Univ, Sch Med, Dept Emergency Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Yeungnam Univ, Coll Med, Dept Emergency Med, Daegu, South Korea; Daegu Catholic Univ, Dept Emergency Med, Sch Med, Daegu, South Korea; Keimyung Univ, Dept Emergency Med, Dongsan Hosp, Daegu, South Korea; Daegu Fatima Hosp, Dept Emergency Med, Daegu, South Korea | Kim, Jung Ho/LDE-9088-2024; Park, Jae Yong/ISS-5916-2023; Lee, Dong Eun/HTN-4501-2023; Yeo, Inhwan/GXZ-7024-2022; Kim, Jungho/LDE-9088-2024; Kim, Joo/JAZ-0897-2023 | 57216815984; 57202299238; 55915816900; 57216816807; 56441824200; 57189030435; 57204305189; 56184913500; 57205704177; 57216815900; 57205602138; 57216817091; 57216816375 | kim7155@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 19 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 3.18 | 2025-06-25 | 43 | 45 | COVID-19 Crisis; Temporary ED Closure; Nosocomial Transmission; Revised Triage; Surveillance Protocol; Chest X-ray | Chest x-ray; COVID-19 crisis; Nosocomial transmission; Revised triage; Surveillance protocol; Temporary ED closure | Adult; Betacoronavirus; Communicable Diseases, Emerging; Coronavirus Infections; Disease Outbreaks; Emergency Medical Services; Emergency Service, Hospital; Female; Health Facility Closure; Humans; Male; Middle Aged; Pandemics; Pneumonia, Viral; Republic of Korea; Retrospective Studies; Tertiary Care Centers; Triage; adult; Betacoronavirus; communicable disease; coronavirus disease 2019; Coronavirus infection; emergency health service; epidemic; female; health care facility; hospital emergency service; human; male; middle aged; pandemic; retrospective study; South Korea; tertiary care center; virus pneumonia | English | 2020 | 2020-05-18 | 10.3346/jkms.2020.35.e189 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Risk Factors for Mortality and Respiratory Support in Elderly Patients Hospitalized with COVID-19 in Korea | Background: The mortality risk of coronavirus disease 2019 (COVID-19) is higher in patients with older age, and many elderly patients are reported to require advanced respiratory support. Methods: We reviewed medical records of 98 patients aged >= 65 years who were hospitalized with COVID-19 during a regional outbreak in Daegu/Gyeongsangbuk-do province of Korea. The outcome measures were in-hospital mortality and the treatment with mechanical ventilation (MV) or high-flow nasal cannula (HFNC). Results: The median age of the patients was 72 years; 55.1% were female. Most (74.5%) had at least one underlying condition. Overall case fatality rate (CFR) was 20.4%, and median time to death after admission was 8 days. The CFR was 6.1% among patients aged 65-69 years, 22.7% among those aged 70-79 years, and 38.1% among those aged >= 80 years. The CFR among patients who required MV was 43.8%, and the proportion of patients received MV/HFNC was 28.6%. Nosocomial acquisition, diabetes, chronic lung diseases, and chronic neurologic diseases were significant risk factors for both death and MV/HFNC. Hypotension, hypoxia, and altered mental status on admission were also associated with poor outcome. CRP > 8.0 mg/dL was strongly associated with MV/HFNC (odds ratio, 26.31; 95% confidence interval, 7.78-88.92; P = 80 years had a high risk of requiring MV/HFNC, and mortality among those severe patients was very high. Severe initial presentation and laboratory abnormalities, especially high CRP, were identified as risk factors for mortality and severe hospital course. | Lee, Ji Yeon; Kim, Hyun Ah; Huh, Kyungmin; Hyun, Miri; Rhee, Ji-Young; Jang, Sukbin; Kim, Ji-Yeon; Peck, Kyong Ran; Chang, Hyun-Ha | Keimyung Univ, Sch Med, Dept Med, Div Infect Dis,Dongsan Hosp, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Infect Dis,Sch Med, Seoul, South Korea; Dankook Univ, Dept Med, Div Infect Dis, Sch Med, Cheonan, South Korea; Seongnam Citizens Med Ctr, Dept Med, Div Infect Dis, Seongnam, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis, 130 Dongdeok Ro, Daegu 41944, South Korea | Peck, Kyong Ran/AGV-5205-2022; Huh, Kyungmin/N-3405-2018 | 57216774221; 57059615500; 55569009500; 55927698200; 55264248300; 57217060526; 59910950100; 55664295200; 7407521688 | krpeck@skku.edu;changhha@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 23 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 6.69 | 2025-06-25 | 66 | 90 | COVID-19; Outcome; Elderly; Risk Factors | COVID-19; Elderly; Outcome; Risk factors | Age Factors; Aged; Aged, 80 and over; Betacoronavirus; C-Reactive Protein; Coronavirus Infections; Female; Hospitalization; Humans; Hypoxia; Intensive Care Units; Male; Pandemics; Pneumonia, Viral; Republic of Korea; Respiration, Artificial; Respiratory Insufficiency; Retrospective Studies; Risk Factors; Treatment Outcome; Ventilators, Mechanical; C reactive protein; age; aged; artificial ventilation; Betacoronavirus; coronavirus disease 2019; Coronavirus infection; female; hospitalization; human; hypoxia; intensive care unit; male; mechanical ventilator; mortality; pandemic; pathology; respiratory failure; retrospective study; risk factor; South Korea; treatment outcome; very elderly; virus pneumonia | English | 2020 | 2020-06-15 | 10.3346/jkms.2020.35.e223 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Significance of Decreasing Rate of HIV and HBV Co-infection in a Nationwide Korean HIV/AIDS Cohort | From December 2006 to December 2016, 1093 human immunodeficiency virus (HIV) individuals < 70 years enrolled in Korea human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) cohort were analyzed to investigate the prevalence of HIV/HBV co-infection rate and hepatitis B virus surface antibody (HBsAb) positive rate based on birth year. The HBV co-infection prevalence rate was the highest (8.8%) in patients born between 1960 and 1964 and the lowest (0%) among those born between 1995 and 1999. A decreasing linear trend of HBV co-infection rate was observed according to the 5-year interval changes. HBsAb-positive rate was only 58.1% in our study. The national HBV vaccination programs have effectively lowered the HBV co-infection rate in HIV population. However, it is identified that the HIV population has low HBsAb positive rate. Further evidences supporting efficacy of booster immunization for HBsAb negative HIV patients are required and efforts should be made to increase HBsAb positive rates among HIV patients to prevent horizontal transmission. | Kim, Yoonjung; Kim, Shin-Woo; Kwon, Ki Tae; Chang, Hyun-Ha; Jun, Yoonhee; Sohn, Jang Wook; Park, Dae Won; Song, Joon Young; Choi, Jun Yong; Kim, Hyo Youl; Kim, June Myung; Choi, Bo Youl; Choi, Yunsu; Kee, Mee-Kyung; Yoo, Myeong Su; Lee, Jung Gyu | Kyungpook Natl Univ, Dept Internal Med, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Div Infect Dis,Dept Internal Med, Seoul, South Korea; Korea Univ, Dept Internal Med, Div Infect Dis, Coll Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Coll Med, AIDS Res Inst, Seoul, South Korea; Hanyang Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; Korea Natl Inst Hlth, Ctr Infect Dis Res, Div Viral Dis Res, Cheongju, South Korea | Choi, Jah/AAA-4835-2022; Choi, Yunsu/AAH-1260-2021; Hwang, Soyoon/HHM-5762-2022; Kim, Jung/S-5543-2017; Kim, Ji Hoon/AAB-4602-2022; Kim, Sun/G-3451-2013 | 57203160508; 8710731500; 9733850500; 7407521688; 55187716200; 7201641941; 55724785200; 57214400146; 57791298700; 56819456800; 57205254273; 55663343300; 57195931031; 8212011900; 57211186635; 57221621997 | ksw2kms@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 3 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 0.32 | 2025-06-25 | 3 | 6 | Hepatitis B Virus; HIV Infection; Co-Infection; Vaccination; National Cohort | HEPATITIS-B VACCINATION; INFECTED PATIENTS; PREVALENCE | Co-infection; Hepatitis B virus; HIV infection; National cohort; Vaccination | Adult; Cohort Studies; Coinfection; Female; Hepatitis B; Hepatitis B Surface Antigens; HIV Infections; Humans; Male; Middle Aged; Republic of Korea; Vaccination; hepatitis B surface antigen; adult; blood; cohort analysis; complication; female; hepatitis B; human; Human immunodeficiency virus infection; male; middle aged; mixed infection; South Korea; vaccination | English | 2020 | 2020-01-20 | 10.3346/jkms.2020.35.e7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | The Author's Response: COVID-19 Antibody Test at Population Level: Why Timing Is the Key | Song, Suk-Kyoon; Lee, Duk-Hee; Cho, Myung-Rae | Daegu Catholic Univ Hosp, Dept Orthoped, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu, South Korea | 57215009048; 57211851121; 35145207900 | cmr0426@cu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 38 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 0 | 2025-06-25 | 0 | 0 | Betacoronavirus; Clinical Laboratory Techniques; Coronavirus; Coronavirus Infections; Humans; Immunoglobulin G; Pandemics; Pneumonia, Viral; Republic of Korea; Seroepidemiologic Studies; immunoglobulin G; Betacoronavirus; Coronavirinae; Coronavirus infection; human; laboratory technique; pandemic; seroepidemiology; South Korea; virus pneumonia | English | 2020 | 2020-09-28 | 10.3346/jkms.2020.35.e339 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Therapeutic Drug Level Monitoring of Teicoplanin in Korean Pediatric Patients with Normal versus Impaired Renal Function | Background: Teicoplanin is used to treat serious gram-positive infections. Optimal teicoplanin trough levels are considered to be >= 10 mu g/mL. Despite its wide use in various clinical settings, data on teicoplanin trough level in pediatric patients are limited. Therefore, the aim of this study was to investigate the therapeutic drug level monitoring of teicoplanin in Korean pediatric patients, including those with impaired renal function. Methods: A retrospective study was performed in pediatric patients (age <= 18 years old) who received teicoplanin from September 2014 to April 2018. The regimen included a loading dose of 10 mg/kg/dose at 12 hours' interval three times in a row, and a maintenance dose of 10 mg/kg/dose commenced at 24 hours of interval after the loading dose, with a maximum of 400 mg/dose, respectively. The first therapeutic drug levels were measured. Distribution and characteristics of trough levels in patients with decreased renal function and those with bacteremia were also assessed. Results: A total of 187 trough levels were collected from 143 patients. Hematologic and oncologic diseases were the most common underlying diseases (83.2%, n = 119). One hundred eighty trough levels were first measured, and their median value was 16.2 mu g/mL (range, 2.3-100 mu g/mL) and the median interval between initial teicoplanin injection and 1st trough level was 96.5 hours (range 47.6-179.3 hours). Lower steady-state levels were observed in younger age group (median, 13.5 vs. 18.0 mu g/mL, P = 0.038). Median trough levels were higher in patients with decreased renal functions (P < 0.001). In addition, among eight with gram-positive bacteremia, seven of them had a favorable outcome. Conclusion: This study provides additive information on trough level monitoring of teicoplanin in children with impaired renal function and treatment effect in patients with gram-positive bacteremia. Careful monitoring for steady state trough levels of teicoplanin is warranted. | Choi, Joon-sik; Kim, Jong Min; Kim, Dongsub; Kim, Si-Ho; Cho, Heeyeon; Park, Hyung-Doo; Lee, Soo-Youn; Kang, Cheol-In; Kim, Yae-Jean | Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, 81 Irwon Ro, Seoul 06351, South Korea; Yonsei Univ Med, Yongin Severance Hosp, Dept Pediat, Yongin, South Korea; Myongji Hosp, Dept Pediat, Goyang, South Korea; Kyungpook Natl Univ Hosp, Dept Pediat, Daegu, South Korea; Samsung Changwon Hosp, Dept Infect Dis, Chang Won, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Lab Med & Genet, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Infect Dis, Seoul, South Korea | ; Kim, Heui-Soo/ABF-3773-2021; Kim, Jong-Min/J-5435-2012; Kim, Junetae/AAS-1234-2021; Lee, YuRim/ITU-1407-2023 | 57205245521; 57022641100; 57205248455; 57194288787; 15724272900; 35206456500; 7601413957; 7402312652; 7410198066 | yaejeankim@skku.edu; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 46 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 0.16 | 2025-06-25 | 1 | 4 | Teicoplanin; Therapeutic Drug Level Monitoring; Children; Impaired Renal Function; Bacteremia | CRITICALLY-ILL PATIENTS; DOSAGE RECOMMENDATIONS; TROUGH CONCENTRATION; VARYING DEGREES; PHARMACOKINETICS; CHILDREN; SAFETY; POPULATION | Bacteremia; Children; Impaired Renal Function; Teicoplanin; Therapeutic Drug Level Monitoring | Administration, Intravenous; Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Female; Glomerular Filtration Rate; Gram-Positive Bacterial Infections; Hematologic Diseases; Humans; Infant; Infant, Newborn; Kidney; Male; Republic of Korea; Retrospective Studies; Tandem Mass Spectrometry; Teicoplanin; antiinfective agent; teicoplanin; adolescent; blood; child; drug administration; female; glomerulus filtration rate; Gram positive infection; hematologic disease; high performance liquid chromatography; human; infant; intravenous drug administration; kidney; male; newborn; physiology; preschool child; retrospective study; South Korea; tandem mass spectrometry | English | 2020 | 2020-11-30 | 10.3346/jkms.2020.35.e376 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Trends of Cause of Death among Human Immunodeficiency Virus Patients and the Impact of Low CD4 Counts on Diagnosis to Death: a Retrospective Cohort Study | Background: Monitoring the full spectrum of causes of death among human immunodeficiency virus (HIV) patients has become increasingly important as survival improves because of highly active antiretroviral therapy. However, there are no recently published data regarding the changes in the causes of death among HIV patients based on year of HIV diagnosis, and the impact of low CD4 count at the time of HIV diagnosis on the clinical outcome is still unclear in Korea. Methods: A retrospective cohort study was conducted with 801 patients with HIV infection who were followed up at a tertiary university hospital and diagnosed with HIV between July 1984 and October 2019. The causes of death were analyzed by descriptive analysis based on CD4 count and the year of HIV diagnosis. Kaplan-Meier and log rank tests were performed to compare the prognosis between the CD4 = 200 cells/me groups. Results: Among 801 patients, 67 patients were eligible for the death cause analysis. Infection-related death accounted for 44 patients (65.7%) and non-infection related death accounted for 23 patients (32.4%). Pneumotystis pneumonia (29.9%) was the single most common cause of death in both past and present cases, and tuberculosis (19.4%) was the second leading cause of death from infections, but the frequency has declined in recent years. Causes of infection-related death have decreased, whereas non-infection related causes of death have increased remarkably. Malignancy-related death was the most common cause of non-infection related death. Acquired immunodeficiency syndrome (AIDS) non-related malignancy accounted for 11.9%, whereas AIDS-related malignancy accounted for 6.0% of the total death among HIV patients. No significant statistical differences were found in mortality rate (P= 0.228), causes of death (P= 0.771), or survival analysis (P= 0.089) between the CD4 = 200 cells/mm(3) groups. Conclusion: Being diagnosed with CD4 = 200 cells/mm(3) group. Malignant tumors have become an important cause of death in recent years, and an increasing tendency of AIDS-non-related malignancy causes has been observed. | Kim, Yoonjung; Kim, Shin-Woo; Chang, Hyun-Ha; Kwon, Ki Tae; Bae, Sohyun; Hwang, Soyoon | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis, 680 Gukchaebosang Ro, Daegu 41944, South Korea | ; Kim, Ji Hoon/AAB-4602-2022; Kim, Hanjin/KYP-2633-2024; Hwang, Soyoon/HHM-5762-2022; Kim, Ik-Sang/J-5425-2012 | 57203160508; 8710731500; 7407521688; 9733850500; 57219699506; 57203160675 | ksw2kms@knu.ac.kr; | JOURNAL OF KOREAN MEDICAL SCIENCE | J KOREAN MED SCI | 1011-8934 | 1598-6357 | 35 | 41 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.153 | 54.8 | 0.16 | 2025-06-25 | 7 | 7 | Cause of Death; Human Immunodeficiency Virus; Human Immunodeficiency Virus Infection; Mortality; Retrospective Cohort | COMBINATION ANTIRETROVIRAL THERAPY; HIV-INFECTED PATIENTS; MORTALITY; KOREA; OUTCOMES; PEOPLE; AIDS; ERA | Cause of Death; Human Immunodeficiency Virus; Human Immunodeficiency Virus Infection; Mortality; Retrospective Cohort | Acquired Immunodeficiency Syndrome; Adult; Anti-Retroviral Agents; Cause of Death; CD4 Lymphocyte Count; Female; HIV Infections; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Pneumonia, Pneumocystis; Retrospective Studies; Risk Factors; Young Adult; antiretrovirus agent; acquired immune deficiency syndrome; adult; cause of death; CD4 lymphocyte count; complication; female; human; Human immunodeficiency virus infection; Kaplan Meier method; male; middle aged; mortality; Pneumocystis pneumonia; retrospective study; risk factor; young adult | English | 2020 | 2020-10-26 | 10.3346/jkms.2020.35.e355 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Magnetic ion-imprinted polymer based on mesoporous silica for selective removal of Co(II) from radioactive wastewater | A magnetically separable Co(II)-imprinted polymer based on mesoporous silica (mag@silica-CIP) was synthesized for use as an adsorbent for the selective removal of Co(II). The optimal pH for Co(II) adsorption was found to be 5. Increasing the amount of the Co(II)-imprinted polymer layer on the surface of mag@silica led to an increase in the maximum adsorption capacity for Co(II). The mag@silica-CIP selectively adsorbed Co(II) even in the presence of competing species such as Fe(II), Ni(II), and Mn(II) ions. Thermodynamic experiments revealed that the adsorption of Co(II) by mag@silica-CIP is an endothermic and spontaneous process. © 2020, © 2020 Taylor & Francis. | Lee, Hyun-Kyu; Choi, Jung-Weon; Choi, Sang-June | Research Institute of Advanced Energy Technology, Kyungpook National University, Daegu, South Korea; School of Architectural, Civil, Environmental, and Energy Engineering, Kyungpook National University, Daegu, South Korea; Research Institute of Advanced Energy Technology, Kyungpook National University, Daegu, South Korea, School of Architectural, Civil, Environmental, and Energy Engineering, Kyungpook National University, Daegu, South Korea | 36465457300; 56996378900; 56605563600 | sjchoi@knu.ac.kr; | Separation Science and Technology (Philadelphia) | SEP SCI TECHNOL | 0149-6395 | 1520-5754 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2020 | 2.475 | 54.9 | 0.62 | 2025-06-25 | 12 | adsorption; Cobalt; ion-imprinted polymer; mesoporous silica; selectivity | Adsorption; Ions; Iron compounds; Manganese compounds; Nickel compounds; Polymers; Radioactive wastes; Silica; Adsorption capacities; Imprinted polymers; Magnetic ions; Magnetically separable; Mesoporous Silica; Radioactive wastewater; Selective removal; Spontaneous process; Cobalt compounds | English | Final | 2020 | 10.1080/01496395.2020.1797798 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Changes of ultrasonographic pattern of the spleen examined with a high-frequency linear transducer during growth in puppies | A normal spleen is a homogeneous, finely textured, and hyperechoic organ. The development of high-frequency transducers has enabled the examination of the structural features of the spleen. Thus, the spleen can appear mildly mottled, even in normal dogs, and this could be misinterpreted as an abnormality. The purpose of this prospective, longitudinal, descriptive study was to describe the ultrasonographic pattern of the splenic parenchyma using a high-frequency transducer in puppies. The study included nine, normal, client-owned puppies that were born healthy. Transabdominal ultrasonographic examination was performed from 4 to 60 weeks serially every 4 weeks. Ultrasonographic patterns of the spleen were graded as follows: granular, mild reticulonodular, moderate reticulonodular, and marked reticulonodular pattern. The examinations were performed by one veterinary clinician, and the grades of the ultrasonographic patterns were determined by two veterinary clinicians experienced in ultrasonography, based on consensus. Differences and associations between time and the grade of the splenic parenchyma were determined using the pairedt-test and scatter plots. There was a strong quadratic relationship between time and the grade of the splenic parenchyma. It was found that the splenic parenchymal patterns changed with increasing age, with a granular appearance initially at 4 weeks, followed by a reticulonodular pattern with well-defined hypoechoic nodules-most marked between 28 and 36 weeks, after which this pattern decreased until there was a homogeneous granular pattern again at 60 weeks. These findings should not be misinterpreted as being indicative of a disease in normal puppies, particularly those aged between 28 and 36 weeks. | Hwang, Youngsun; Noh, Daji; Choi, Sooyoung; Choi, Hojung; Lee, Youngwon; Lee, Kija | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kangwon Natl Univ, Coll Vet Med, Chunchon, South Korea; Chungnam Natl Univ, Coll Vet Med, Daejeon, South Korea | 57217144595; 57188552722; 55736574600; 35202930200; 8983566800; 35311016000 | leekj@knu.ac.kr; | VETERINARY RADIOLOGY & ULTRASOUND | VET RADIOL ULTRASOUN | 1058-8183 | 1740-8261 | 61 | 5 | SCIE | VETERINARY SCIENCES | 2020 | 1.363 | 55.1 | 1.1 | 2025-06-25 | 5 | 7 | reticulonodular; splenic echotexture; ultrasound; young dogs | IMMUNE-SYSTEM DEVELOPMENT; SEX-HORMONES; APPEARANCE; AGE; DOG | reticulonodular; splenic echotexture; ultrasound; young dogs | Animals; Dogs; Female; Longitudinal Studies; Male; Parenchymal Tissue; Prospective Studies; Reference Values; Spleen; Transducers; Ultrasonography; adult; Article; body weight; echography; female; image analysis; inguinal region; male; nonhuman; parenchyma; prospective study; puppy; spleen; veterinary medicine; animal; diagnostic imaging; dog; echography; longitudinal study; reference value; spleen; transducer; veterinary medicine | English | 2020 | 2020-09 | 10.1111/vru.12873 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Association of FOSB exon 4 unmethylation with poor prognosis in patients with late-stage non-small cell lung cancer | Alterations in DNA methylation have a central role in the development and outcome of most human malignancies. Non-small cell lung cancer (NSCLC), the most common lung cancer, leads to the largest number of cancer-related deaths worldwide. FBJ murine osteosarcoma viral oncogene homolog B (FOSB) is a key component of the activator protein-1 transcription factor and regulates gene networks associated within oncogenic transformation. The role of FOSB in the development of NSCLC is still elusive. Therefore, the methylation status of the FOSB gene was investigated in NSCLC and its clinical significance in NSCLC progression was evaluated. The methylation status of the promoter and exon 4 regions of the FOSB gene were analyzed in 176 NSCLC specimens by bisulfite pyrosequencing and the association between FOSB methylation status and patient survival was investigated. Compared to adjacent non-malignant tissues, FOSB promoter exhibited exclusive unmethylation in all malignant tissues and the exon 4 region was found unmethylated in 18 (10.2% of the total) tumor samples. Exon 4 unmethylation was associated with downregulation of its mRNA and tended to occur in patients with lymph node metastasis. Univariate and multivariate analyses revealed that exon 4 unmethylation was significantly associated with unfavorable overall survival in patients with stage II-IIIA NSCLC (log-rank P=0.05, adjusted hazard ratio=2.43, 95% confidence interval=1.04-5.68, P=0.04). FOSB was identified as a novel gene with tumor-specific gene body unmethylation in NSCLC and a novel predictive biomarker for NSCLC prognosis. Moreover, the present results indicated that FOSB may have a tumor suppressor function in the progression of NSCLC. | Kim, Dong Sun; Lee, Won Kee; Park, Jae Yong | Kyungpook Natl Univ, Sch Med, Dept Anat, Daegu 702422, South Korea; Kyungpook Natl Univ, Sch Med, BK21 Plus KNU Biomed Convergence Program, Daegu 702422, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu 702422, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, 2-101 Dongin Dong, Daegu 702422, South Korea | ; Kim, Dae/AAJ-7518-2021 | 57125070500; 22953484700; 58360293800 | jaeyong@knu.ac.kr; | ONCOLOGY REPORTS | ONCOL REP | 1021-335X | 1791-2431 | 43 | 2 | SCIE | ONCOLOGY | 2020 | 3.906 | 55.2 | 0.13 | 2025-06-25 | 4 | 3 | promoter; exon; unmethylation; FOSB; NSCLC; prognosis | DNA METHYLATION; TRANSCRIPTION FACTORS; INVASION; MIGRATION; ADENOCARCINOMA; EXPRESSION; FAMILY; GENES; AP-1 | Exon; FOSB; NSCLC; Prognosis; Promoter; Unmethylation | Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; DNA Methylation; Exons; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Sequence Analysis, DNA; Survival Analysis; messenger RNA; FOSB protein, human; protein c fos; adult; aged; Article; bisulfite pyrosequencing; cancer growth; cancer prognosis; cancer staging; controlled study; DNA methylation; down regulation; exon; female; FOSB gene; gene; genetic association; human; human cell; human tissue; lymph node metastasis; major clinical study; male; non small cell lung cancer; overall survival; priority journal; promoter region; risk factor; survival rate; cancer staging; DNA sequence; exon; gene expression regulation; genetics; lung tumor; middle aged; mortality; non small cell lung cancer; pathology; procedures; prognosis; survival analysis; tumor cell line; very elderly | English | 2020 | 2020-02 | 10.3892/or.2019.7431 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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