연구성과로 돌아가기
2024 연구성과 (172 / 286)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Effect of the number and distribution of Al2O3 atomic layer deposition cycles within HfO2 layer on ferroelectric characteristics | We comprehensively analyze the effects of the number and distribution of All(2)O(3) atomic layer deposition (ALD) cycles into a 10-nm-thick HfO2 matrix on the ferroelectric switching behavior. An ALD cycle containing one pulse for Hf (or Al) precursor and one pulse of water as reactant is repeated 150 times for the given thickness of 10 nm. Spontaneous remnant polarization (Pr) is enabled through the formation of crystalline Al-doped HfO2 (Al:HfO2) by incorporating at least two All(2)O(3) ALD cycles evenly into the HfO2 film under annealing at 600 degrees C for 3 min following W top electrode (TE) deposition. When more than four All(2)O(3) cycles are used, the Al elements function as leakage sources rather than stressors, resulting in an open hysteresis loop and a weak endurance of 105 cycles. Notably, an improved 2 P-r of similar to 9 mu C/cm(2) is achieved when the All(2)O(3) layers are concentrated near the lower region of the HfO2. On the other hand, as the All(2)O(3) layers are intensively located in the upper region of the HfO2, a dielectric response is observed in the polarization-voltage and current-voltage measurements. Our results indicate that the two mechanical stresses induced by the Al dopant with a size smaller than Hf and the difference in the thermal expansion coefficient between TE and Al:HfO2 effectively activate both the lower and upper sites. Therefore, many dipoles are observed to participate in the polarization owing to the stresses that are applied evenly throughout the Al:HfO2 layer to form the orthorhombic phase. | Park, Hyoungjin; Jeong, Jiae; Kim, Hyun Wook; Hong, Eunryeong; Kim, Nayeon; Jeon, Seonuk; Kim, Yunsur; Choi, Hyeonsik; Woo, Jiyong | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 58964076600; 58963433800; 57557016000; 57556070800; 59884547500; 57955098300; 58847712800; 58835686900; 53985749100 | jiyong.woo@knu.ac.kr; | APPLIED PHYSICS LETTERS | APPL PHYS LETT | 0003-6951 | 1077-3118 | 124 | 13 | SCIE | PHYSICS, APPLIED | 2024 | 3.6 | 35.6 | 1.14 | 2025-05-07 | 3 | 2 | LOW THERMAL-BUDGET; THIN-FILMS; TRANSISTORS; MEMORY | Alumina; Aluminum; Aluminum oxide; Atomic layer deposition; Ferroelectricity; Hafnium oxides; Thermal expansion; Al-doped; Atomic-layer deposition; Deposition cycles; Ferroelectric characteristics; Ferroelectric switching; HfO 2; Is-enabled; matrix; Remnant polarizations; Switching behaviors; Polarization | English | 2024 | 2024-03-25 | 10.1063/5.0202549 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A Multicenter Survey of Percutaneous Endoscopic Gastrostomy in 2019 at Korean Medical Institutions | Background/Aims: This study aimed to review the indications, methods, cooperation, complications, and outcomes of percutaneous endoscopic gastrostomy (PEG). Methods: Questionnaires were sent to 200 hospitals, of which 62 returned their questionnaires, with a response rate of approximately 30%. Descriptive statistics were calculated to analyze the responses to the questionnaires. Results: In 2019, a total of 1,052 PEGs were performed in 1,017 patients at 62 hospitals. The main group who underwent PEG was older adult patients with brain disease, particularly stroke. Nutritional supply was an important purpose of the PEG procedure. "The pull method" was the most commonly used for initial PEG insertion. The complications related to PEG were mostly mild, with leakage being the most common. Patients who underwent PEG procedures were primarily educated regarding the post-procedure management and complications related to PEG. Preoperative meetings were skipped at >50% of the institutions. Regarding the cooperation between the nutrition support team (NST) and the physician performing PEG, few endoscopists answered that they cooperated with NST before and after PEG. Moreover, the rate of NST certification obtained by physicians performing PEG and the frequency of attendance at NST-related conferences were relatively low. Conclusions: This study shows a similar trend to that found in the previous PEG guidelines. However, it covers new aspects, including team-based work for PEG procedure, nutrition support, and education for patients and guardians. Therefore, each medical institution needs to select an appropriate method considering the medical environment and doctor's abilities. | Park, Jun Woo; Kim, Tae Gyun; Cho, Kwang Bum; Kim, Jeong Seok; Cho, Jin Woong; Jeon, Jung Won; Lim, Sun Gyo; Kim, Chan Gyoo; Park, Hong Jun; Kim, Tae Jun; Kim, Eun Sun; Jeong, Su Jin; Kwon, Yong Hwan | Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Presbyterian Med Ctr, Dept Internal Med, Jeonju, South Korea; Kyung Hee Univ, Dept Internal Med, Med Ctr, Seoul, South Korea; Ajou Univ, Dept Gastroenterol, Sch Med, Suwon, South Korea; Natl Canc Ctr, Ctr Gastr Canc, Goyang, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med, Seoul, South Korea; Korea Univ, Coll Med, Dept Gastroenterol, Seoul, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Pediat Gastroenterol, Seongnam, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | ; Kim, Sun/C-2026-2011; Lim, Sun Gyo/GZL-8052-2022; Kim, TaeHeon/KIC-2380-2024 | 58815179800; 58815129100; 7403956834; 55636277000; 53163643000; 57215598164; 14621830600; 57218674652; 57096148200; 57189389501; 56308204100; 57192812021; 55775556800 | tear1480@hanmail.net; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 18 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.2 | 35.7 | 0 | 2025-04-16 | 1 | 1 | Surveys and questionnaires; Percutaneous endoscopic gastrostomy; Enteral nutrition | ENTERAL NUTRITION; PARENTERAL-NUTRITION; ADULT PATIENTS; GUIDELINES; PLACEMENT; MORTALITY; OUTCOMES; SOCIETY; HEAD | Enteral nutrition; Percutaneous endoscopic gastrostomy; Surveys and questionnaires | Aged; Enteral Nutrition; Gastroscopy; Gastrostomy; Humans; Republic of Korea; Retrospective Studies; Surveys and Questionnaires; antacid agent; antibiotic agent; cholinergic receptor blocking agent; adult; age distribution; Article; aspiration pneumonia; brain disease; buried bumper syndrome; calculation; cerebrovascular accident; certification; clinical feature; clinical outcome; consensus development; constipation; controlled study; cooperation; data analysis; device migration; diarrhea; dietitian; educational status; endoscopist; enteric feeding; female; gastrointestinal hemorrhage; granulation tissue; health care survey; hospital; human; infection; leakage; major clinical study; male; middle aged; nutrition support team; patient education; percutaneous endoscopic gastrostomy; physician; pneumonia; pneumoperitoneum; postoperative complication; preoperative period; questionnaire; South Korea; statistical analysis; surgical infection; surgical technique; treatment indication; tube displacement; vomiting; young adult; aged; clinical trial; enteric feeding; gastroscopy; gastrostomy; multicenter study; procedures; retrospective study; South Korea | English | 2024 | 2024-01 | 10.5009/gnl230174 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Anti-Inflammatory Activities of (+)-Afzelechin against Lipopolysaccharide-Induced Inflammation | In this study, we investigated the potential protective effects of (+)-afzelechin (AZC), a natural compound that is derived from Bergenia ligulata, on lipopolysaccharide (LPS)-induced inflammatory responses. AZC is known to have antioxidant, anticancer, antimicrobial, and cardiovascular protective properties. However, knowledge regarding the therapeutic potential of AZC against LPS-induced inflammatory responses is limited. Thus, we investigated the protective attributes of AZC against inflammatory damage caused by LPS exposure. We examined the effects of AZC on heme oxygenase (HO)-1, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) in LPS-activated human umbilical vein endothelial cells (HUVECs). In addition, the effects of AZC on the expression of iNOS, tumor necrosis factor (TNF)-a, and interleukin (IL)-18 were analyzed in the lung tissues of LPSinjected mice. Data revealed that AZC promoted the production of HO-1, inhibited the interaction between luciferase and nuclear factor (NF)-KB, and reduced the levels of COX-2/PGE2 and iNOS/NO, thereby leading to a decrease in the signal transducer and activator of transcription (STAT)-1 phosphorylation. Moreover, AZC facilitated the nuclear translocation of Nrf2, increased the binding activity between Nrf2 and the antioxidant response elements (AREs), and lowered the expression of IL-18 in the LPS-treated HUVECs. In the animal model, AZC significantly reduced the expression of iNOS in the lung tissue structure and the TNF-a level in the bronchoalveolar lavage fluid. These findings demonstrate that AZC possesses anti-inflammatory properties that regulate iNOS through the inhibition of both NF-KB expression and p-STAT-1. Consequently, AZC has potential as a future candidate for the development of new clinical substances for the treatment of pathological inflammation. | Lee, In-Chul; Bae, Jong-Sup | Seowon Univ, Dept Cosmet Sci & Technol, Cheongju 28674, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea | 56390536600; 16021543200 | baejs@knu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 32 | 4 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3.2 | 35.7 | 0.93 | 2025-05-07 | 2 | 2 | (+)-Afzelechin; Endothelium; iNOS; p-STAT-1 | NF-KAPPA-B; CARBON-MONOXIDE; IN-VITRO; INHIBITION; THERAPY; RELEASE; PATHWAY; COX-2 | (+)-Afzelechin; Endothelium; iNOS; p-STAT-1 | afzelechin; chemical compound; cyclooxygenase 2 inhibitor; heme oxygenase; heme oxygenase 1; interleukin 1beta; lipopolysaccharide; nitric oxide; nitric oxide synthase; nitrite; prostaglandin synthase; STAT1 protein; transcription factor Nrf2; tumor necrosis factor; unclassified drug; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant responsive element; Article; bronchoalveolar lavage fluid; cell fractionation; cell viability assay; clinical outcome; controlled study; down regulation; endothelium; enzyme linked immunosorbent assay; gene expression; genetic transfection; histology; histopathology; human; human cell; HUVEC cell line; immunoblotting; infant; intracellular fractionation; JAK-STAT signaling; lipopolysaccharide-induced acute lung injury; lipopolysaccharide-induced inflammation; luciferase assay; lung injury; lung parenchyma; mouse; MTT assay; NF kB signaling; nonhuman; protein expression; protein phosphorylation; real time polymerase chain reaction; signal transduction | English | 2024 | 2024-07 | 10.4062/biomolther.2023.204 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Current Diagnosis and Treatment of Acute Pancreatitis in Korea: A Nationwide Survey | Background/Aims: Acute pancreatitis (AP) is a leading cause of emergency hospitalization. We present the current diagnostic and therapeutic status of AP as revealed by analysis of a large multicenter dataset. Methods: The medical records of patients diagnosed with AP between 2018 and 2019 in 12 tertiary medical centers in Korea were retrospectively reviewed. Results: In total, 676 patients were included, of whom 388 (57.4%) were male, and the mean age of all patients was 58.6 years. There were 355 (52.5%), 301 (44.5%), and 20 (3.0%) patients with mild, moderate, and severe AP, respectively, as assessed by the revised Atlanta classification. The most common etiologies of AP were biliary issues (41.6%) and alcohol consumption (24.6%), followed by hypertriglyceridemia (6.8%). The etiology was not identified in 111 (16.4%) patients at the time of initial admission. The overall mortality rate was 3.3%, increasing up to 45.0% among patients with severe AP. Notably, 70.0% (14/20) of patients with severe AP and 81.5% (154/189) of patients with systemic inflammatory response syndrome had received <4 L per day during the initial 24 hours of admission. Only 23.8% (67/281) of acute biliary pancreatitis patients underwent cholecystectomy during their initial admission. In total, 17.8% of patients experienced recurrent attacks during follow-up. However, none of the patients with acute biliary pancreatitis experienced recurrent attacks if they had undergone cholecystectomy during their initial admission. Conclusions: This study provides insights into the current status of AP in Korea, including its etiology, severity, and management. Results reveal disparities between clinical guidelines and their practical implementation for AP treatment. | Kim, Eui Joo; Lee, Sang Hyub; Jung, Min Kyu; Jang, Dong Kee; Jo, Jung Hyun; Lee, Jae Min; Choe, Jung Wan; Han, Sung Yong; Choi, Young Hoon; Kim, Seong-Hun; Park, Jin Myung; Paik, Kyu-Hyun | Gachon Univ, Coll Med, Gil Med Ctr, Dept Internal Med, Incheon, South Korea; Inha Univ, Grad Sch, Dept Med, Incheon, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Liver Res Inst, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul Metropolitan Govt,Coll Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Changwon Hosp, Chang Won, South Korea; Korea Univ, Coll Med, Dept Internal Med, Ansan Hosp, Ansan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Dept Internal Med, Busan, South Korea; Pusan Natl Univ Sch Med, Busan, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Jeonbuk Natl Univ, Dept Internal Med, Res Inst Clin Med, Biomed Res Inst,Jeonbuk Natl Univ Hosp, Jeonju, South Korea; Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Dept Internal Med, Chunchon, South Korea; Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Dept Internal Med, Daejeon, South Korea | ; Jo, Jung Hyun/V-8316-2019; Lee, Jun Young/CAI-2335-2022; KANG, MIN KYU/ACI-8824-2022; Kim, Eui/P-8348-2019 | 36102878900; 36062488800; 56783168100; 56091787300; 55532796800; 8636426500; 56481120200; 57190127827; 57212256431; 57206878084; 57205232842; 56828960800 | gidoctor@snu.ac.kr;minky1973@knu.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 18 | 5 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.2 | 35.7 | 0.48 | 2025-05-07 | 1 | 1 | Pancreatitis; Epidemiology; Diagnosis; Therapeutics | OBESITY; ADMISSION | Diagnosis; Epidemiology; Pancreatitis; Therapeutics | Acute Disease; Adult; Aged; Female; Humans; Male; Middle Aged; Pancreatitis; Republic of Korea; Retrospective Studies; Severity of Illness Index; antibiotic agent; proton pump inhibitor; acute biliary pancreatitis; acute pancreatitis; adult; age distribution; alcohol consumption; Article; biliary tract disease; cholangitis; cholecystectomy; cholecystitis; controlled study; convalescence; disease classification; disease severity; female; fever; fluid resuscitation; follow up; health care delivery; health disparity; health survey; hospital admission; human; hypertriglyceridemia; infection; major clinical study; male; medical record review; mortality rate; necrosis; nose feeding; population research; practice guideline; recurrent disease; retrospective study; sex ratio; shock; South Korea; systemic inflammatory response syndrome; tertiary care center; acute disease; aged; clinical trial; diagnosis; epidemiology; etiology; middle aged; mortality; multicenter study; pancreatitis; severity of illness index; therapy | English | 2024 | 2024-09 | 10.5009/gnl230350 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Diagnosis and Treatment of Perihilar Cholangiocarcinoma: A National Survey from the Korean Pancreatobiliary Association | Background/Aims: Based on their anatomy, cholangiocarcinomas (CCAs) are classified into intrahepatic, hilar, and distal CCAs. Although the diagnosis and treatment of each type of CCA are thought to be different, real-world data studies on the current practice are limited. Therefore, this study was designed to capture the current practice of diagnosing and treating perihilar CCA in Korea.Methods: We conducted a survey using an online platform. The questionnaire consisted of 18 questions designed to evaluate the current practice of diagnosing and treating perihilar CCA in Korea. The targets of this survey were biliary endoscopists who are members of the Korean Pancreatobiliary Association.Results: In total, 119 biliary endoscopists completed the survey. Of the respondents, 89.9% thought that the use of the International Classification of Diseases, 11th Revision (ICD-11) system is necessary to classify CCA. Approximately half of the respondents would recommend surgery or chemotherapy until patients were 80 years of age. For the pathological diagnosis of CCA, endo-scopic retrograde cholangiopancreatography with biopsy was the most preferred modality. Routine preoperative biliary drainage was performed by 44.5% of the respondents. For operable CCAs, 64.7% of the respondents preferred endoscopic biliary drainage using plastic stents. For palliative biliary drainage, 69.7% of the respondents used plastic stents. For palliative endoscopic biliary drainage using metal stents, 63% of the respondents preferred the stent-in-stent method.Conclusions: A new coding system using the ICD-11 is needed for classifying CCAs. Guidelines for diagnosing and treating CCA based on the clinical situation in Korea are needed. (Gut Liver, Published online April 20, 2023) | Cho, Eunae; Kim, Seong-Hun; Choi, Seong Ji; Jung, Min Kyu; Song, Byeong Jun; Park, Jin Myung; Kang, Jingu; Park, Won Suk; Park, Joo Kyung; Woo, Sang Myung; Kim, Hyo Jung | Chonnam Natl Univ, Med Sch, Dept Internal Med, Div Gastroenterol, Gwangju, South Korea; Jeonbuk Natl Univ, Med Sch, Div Gastroenterol, Dept Internal Med, Jeonju, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Biomed Res Inst, Res Inst Clin Med, Jeonju, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Daegu, South Korea; Myongji Hosp, Dept Internal Med, Div Gastroenterol, Goyang, South Korea; Kangwon Natl Univ, Dept Internal Med, Sch Med, Chunchon, South Korea; Kangdong Sacred Heart Hosp, Dept Gastroenterol, Seoul, South Korea; Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Dept Internal Med, Daejeon, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Internal Med,Div gastroenterol, Seoul, South Korea; Natl Canc Ctr, Res Inst, Ctr Liver & Pancreatobiliary Canc, Goyang, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Seoul, South Korea | Choi, Won/V-2730-2017; Kim, Young/J-5414-2012 | 57225705236; 57206878084; 57202151295; 56783168100; 57194420427; 57205232842; 57030966000; 58815177000; 57203537385; 14038271300; 56995392900 | hjkimmd@korea.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 18 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.2 | 35.7 | 0 | 2025-04-16 | 2 | 1 | Cholangiocarcinoma; Diagnosis; Treatment; Surveys and questionnaires | PREOPERATIVE BILIARY DRAINAGE; MULTICENTER; CHEMOTHERAPY; STRICTURES; CANCER | Cholangiocarcinoma; Diagnosis; questionnaires; Surveys; Treatment | Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Cholangiopancreatography, Endoscopic Retrograde; Drainage; Humans; Klatskin Tumor; Republic of Korea; Stents; antineoplastic agent; adult; aged; Article; biliary tract drainage; cancer chemotherapy; cholangioscopy; endoscopic nasobiliary drainage; endoscopic retrograde biliary drainage; endoscopic retrograde cholangiopancreatography; endoscopist; female; groups by age; human; ICD-11; Klatskin tumor; male; medical society; palliative therapy; percutaneous transhepatic biliary drainage; South Korea; stent in stent method; surgical technique; tumor biopsy; ultrasound guided fine needle aspiration; bile duct carcinoma; bile duct tumor; intrahepatic bile duct; Klatskin tumor; pathology; procedures; surgery | English | 2024 | 2024-01 | 10.5009/gnl220413 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effect of Kaempferol on Modulation of Vascular Contractility Mainly through PKC and CPI-17 Inactivation | In this study, we investigated the efficacy of kaempferol (a flavonoid found in plants and plant-derived foods such as kale, beans, tea, spinach and broccoli) on vascular contractibility and aimed to clarify the detailed mechanism underlying the relaxation. Isometric contractions of divested muscles were stored and linked with western blot analysis which was carried out to estimate the phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) and phosphorylation-dependent inhibitory protein for myosin phosphatase (CPI-17) and to estimate the effect of kaempferol on the RhoA/ROCK/CPI-17 pathway. Kaempferol conspicuously impeded phorbol ester-, fluoride- and a thromboxane mimetic-derived contractions regardless of endothelial nitric oxide synthesis, indicating its direct effect on smooth muscles. It also conspicuously impeded the fluoride-derived elevation in phospho-MYPT1 rather than phospho-CPI-17 levels and phorbol 12,13-dibutyrate-derived increase in phospho-CPI-17 and phospho-ERK1/2 levels, suggesting the depression of PKC and MEK activities and subsequent phosphorylation of CPI-17 and ERK1/2. Taken together, these outcomes suggest that kaempferol-derived relaxation incorporates myosin phosphatase retrieval and calcium desensitization, which appear to be modulated by CPI-17 dephosphorylation mainly through PKC inactivation. | Yoon, Hyuk-Jun; Moon, Heui Woong; Min, Young Sil; Jin, Fanxue; Bang, Joon Seok; Sohn, Uy Dong; Je, Hyun Dong | Daegu Catholic Univ, Coll Pharm, Dept Pharm, Gyongsan 38430, South Korea; Jungwon Univ, Dept Pharmaceut Sci, Goesan 28024, South Korea; Kyungpook Natl Univ, Sch Med, Daegu 41944, South Korea; Sookmyung Womens Univ, Coll Pharm, Seoul 04310, South Korea; Chung Ang Univ, Coll Pharm, Dept Pharmacol, Seoul 06974, South Korea | 57201590819; 59125904400; 7202198543; 12788216300; 36855449200; 57188573852; 57221755247 | hyundong@cu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 32 | 3 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3.2 | 35.7 | 0 | 2025-05-07 | 1 | 1 | CPI-17; Fluoride; Kaempferol; MYPT1; Phorbol ester; PKC | LIGHT-CHAIN PHOSPHATASE; SMOOTH-MUSCLE; RHO-KINASE; CA2+ SENSITIZATION; TARGET SUBUNIT-1; MYOSIN; PHOSPHORYLATION; ACTIVATION; MYPT1; PROTEIN | CPI-17; Fluoride; Kaempferol; MYPT1; Phorbol ester; PKC | etomidate; fluoride; kaempferol; myosin; nitric oxide; phosphorylation dependent inhibitory protein for myosin phosphatase; protein kinase C; unclassified drug; vasoconstrictor agent; animal experiment; animal model; animal tissue; Article; chemoluminescence; controlled study; immunoblotting; muscle contraction; nonhuman; polyacrylamide gel electrophoresis; protein expression; protein phosphorylation; rat; vascular contractility; Western blotting | English | 2024 | 2024-05 | 10.4062/biomolther.2023.186 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effects of Corticosterone on Beta-Amyloid-Induced Cell Death in SH-SY5Y Cells | Alzheimer's disease (AD) is a neurodegenerative disease characterized by neuronal cell death and memory impairment. Corticosterone (CORT) is a glucocorticoid hormone produced by the hypothalamic-pituitary-adrenal axis in response to a stressful condition. Excessive stress and high CORT levels are known to cause neurotoxicity and aggravate various diseases, whereas mild stress and low CORT levels exert beneficial actions under pathophysiological conditions. However, the effects of mild stress on AD have not been clearly elucidated yet. In this study, the effects of low (3 and 30 nM) CORT concentration on A beta(25-35)-induced neurotoxicity in SH-SY5Y cells and underlying molecular mechanisms have been investigated. Cytotoxicity caused by A beta(25-35) was significantly inhibited by the low concentration of CORT treatment in the cells. Furthermore, CORT pretreatment significantly reduced A beta(25-35)-mediated pro-apoptotic signals, such as increased Bim/Bcl-2 ratio and caspase-3 cleavage. Moreover, low concentration of CORT treatment inhibited the A beta(25-35)-induced cyclooxygenase-2 and pro-inflammatory cytokine expressions, including tumor necrosis factor-alpha and interleukin-1 beta. A beta(25-35) resulted in intracellular accumulation of reactive oxygen species and lipid peroxidation, which were effectively reduced by the low CORT concentration. As a molecular mechanism, low CORT concentration activated the nuclear factor-erythroid 2-related factor 2, a redox-sensitive transcription factor mediating cellular defense and upregulating the expression of antioxidant enzymes, such as NAD(P)H:quinone oxidoreductase, glutamylcysteine synthetase, and manganese superoxide dismutase. These findings suggest that low CORT concentration exerts protective actions against A beta(25-35)-induced neurotoxicity and might be used to treat and/or prevent AD. | Do, Bo Kyeong; Jang, Jung-Hee; Park, Gyu Hwan | Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Keimyung Univ, Sch Med, Dept Pharmacol, Daegu 42601, South Korea | 58785088000; 7402965470; 9939639300 | pamy202@kmu.ac.kr;park014@knu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 32 | 1 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3.2 | 35.7 | 1.04 | 2025-04-16 | 2 | 2 | Corticosterone; Beta-amyloid; Neurotoxicity; Alzheimer's disease; Oxidative stress; Inflammation | ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; OXIDATIVE STRESS; GLUCOCORTICOIDS; RESILIENCE; TOXICITY; HEALTH; YOUNG | Alzheimer’s disease; Beta-amyloid; Corticosterone; Inflammation; Neurotoxicity; Oxidative stress | amyloid beta protein; amyloid beta protein[25-35]; BIM protein; brain derived neurotrophic factor; caspase 3; corticosterone; cyclooxygenase 2; interleukin 1beta; manganese superoxide dismutase; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein bcl 2; reactive oxygen metabolite; reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone); transcription factor Nrf2; tumor necrosis factor; Alzheimer disease; apoptosis; Article; cell culture; cell death; cell survival; cell viability; cell viability assay; controlled study; cytotoxicity; drug effect; human; human cell; hypothalamus hypophysis adrenal system; inflammation; lipid peroxidation; MTT assay; nervous system inflammation; neurotoxicity; oxidative stress; pathophysiology; physiological stress; protein expression; protein phosphorylation; SH-SY5Y cell line; upregulation; Western blotting | English | 2024 | 2024-01 | 10.4062/biomolther.2023.133 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of the Efficacy and Safety of DW1903 in Patients with Gastritis: A Randomized, Double-Blind, Noninferiority, Multicenter, Phase 3 study | Background/Aims: H2 receptor antagonists (H2RA) have been used to treat gastritis by inhibit-ing gastric acid. Proton pump inhibitors (PPIs) are more potent acid suppressants than H2RA. However, the efficacy and safety of low-dose PPI for treating gastritis remain unclear. The aim was to investigate the efficacy and safety of low-dose PPI for treating gastritis.Methods: A double-blind, noninferiority, multicenter, phase 3 clinical trial randomly assigned 476 patients with endoscopic erosive gastritis to a group using esomeprazole 10 mg (DW1903) daily and a group using famotidine 20 mg (DW1903R1) daily for 2 weeks. The full-analysis set in-cluded 319 patients (DW1903, n=159; DW1903R1, n=160) and the per-protocol set included 298 patients (DW1903, n=147; DW1903R1, n=151). The primary endpoint (erosion improvement rate) and secondary endpoint (erosion and edema cure rates, improvement rates of hemorrhage, erythema, and symptoms) were assessed after the treatment. Adverse events were compared.Results: According to the full-analysis set, the erosion improvement rates in the DW1903 and DW1903R1 groups were 59.8% and 58.8%, respectively. According to the per-protocol analysis, the erosion improvement rates in the DW1903 and DW1903R1 groups were 61.9% and 59.6%, respectively. Secondary endpoints were not significantly different between two groups except that the hemorrhagic improvement rate was higher in DW1903 with statistical tendency. The number of adverse events were not statistically different.Conclusions: DW1903 of a low-dose PPI was not inferior to DW1903R1 of H2RA. Thus, low-dose PPI can be a novel option for treating gastritis (ClinicalTrials.gov Identifier: NCT05163756). (Gut Liver, Published online June 13, 2023) | Kim, Jie-Hyun; Jung, Hwoon-Yong; Yoo, In Kyung; Park, Seon-Young; Kim, Jae Gyu; Sung, Jae Kyu; Jang, Jin Seok; Cheon, Gab Jin; Kim, Kyoung Oh; Kim, Tae Oh; Lee, Soo Teik; Cho, Kwang Bum; Chun, Hoon Jai; Park, Jong-Jae; Park, Moo In; Jang, Jae-Young; Jeon, Seong Woo; Cho, Jin Woong; Kang, Dae Hwan; Kim, Gwang Ha; Kim, Jae J.; Kim, Sang Gyun; Kim, Nayoung; Lee, Yong Chan; Hong, Su Jin; Kim, Hyun-Soo; Lee, Sora; Lee, Sang Woo | Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Gastroenterol, Coll Med, Seoul, South Korea; Cha Bundang Med Ctr, Dept Internal Med, Div Gastroenterol, Seongnam, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea; Chung Ang Univ, Dept Internal Med, Div Gastroenterol, Coll Med, Seoul, South Korea; Chungnam Natl Univ, Dept Internal Med, Coll Med, Daejeon, South Korea; Dong A Univ, Dept Internal Med, Coll Med, Busan, South Korea; Univ Ulsan, Gangneung Asan Hosp, Dept Internal Med, Coll Med, Kangnung, South Korea; Gachon Univ, Gil Med Ctr, Dept Gastroenterol, Coll Med, Incheon, South Korea; Inje Univ, Coll Med, Dept Internal Med, Haeundae Paik Hosp, Busan, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Dept Internal Med, Div Gastroenterol,Med Sch, Jeonju, South Korea; Keimyung Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Sch Med, Daegu, South Korea; Korea Univ, Dept Gastroenterol, Anam Hosp, Seoul, South Korea; Korea Univ, Dept Gastroenterol, Guro Hosp, Seoul, South Korea; Kosin Univ, Dept Internal Med, Div Gastroenterol, Coll Med, Busan, South Korea; Kyung Hee Univ, Coll Med, Dept Internal Med, Div Gastroenterol & Hepatol, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Presbyterian Med Ctr, Dept Internal Med, Jeonju, South Korea; Pusan Natl Univ, Dept Internal Med, Yangsan Hosp, Yangsan, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst, Dept Internal Med,Coll Med, Busan, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Liver Res Inst, Dept Internal Med,Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Soonchunhyang Univ, Dept Internal Med, Coll Med, Bucheon, South Korea; Wonju Severance Christian Hosp, Dept Internal Med, Wonju, South Korea; Daewon Pharmaceut, Clin R&D Dept, Seoul, South Korea; Korea Univ, Dept Gastroenterol, Ansan Hosp, Ansan, South Korea | ; Kim, Hyung/J-5451-2012; Lee, Si/ABH-1408-2020; Jeon, Seongwoo/AAU-4618-2020; Kim, Nayoung/J-5387-2012; Kim, Sang-Hyun/J-5402-2012; Lee, Young/AAI-1932-2020; Kim, Jie-Hyun/Q-9061-2019; Kim, Gwang Ha/ABF-3932-2021; Park, Jinkyeong/GLV-1649-2022; Kang, Dae/A-4703-2011; Kim, Ji/AAU-5043-2020; Kim, Sang/J-5398-2012; Jang, Jae/AAN-1508-2020 | 49461401400; 7403029804; 56041681800; 7501833800; 57486236700; 8439931900; 8444835300; 7003953934; 12778286500; 57189056554; 7601418502; 7403956834; 7202215162; 34668368400; 8666034000; 57215881098; 9733636500; 53163643000; 23090971800; 35214772400; 36067967700; 56371524600; 57201181440; 35264717600; 35285527200; 55739553100; 58815064000; 57218683827 | leesw@korea.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 18 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.2 | 35.7 | 0.53 | 2025-04-16 | 1 | 1 | Gastritis; Phase III clinical trial; Proton pump inhibitors; Histamine H2 antagonists | SYMPTOM RELIEF; OMEPRAZOLE; DA-9601; DISEASE | Gastritis; Histamine H2 antagonists; Phase III clinical trial; Proton pump inhibitors | Double-Blind Method; Famotidine; Gastritis; Histamine H2 Antagonists; Humans; Proton Pump Inhibitors; dw 1903; dw 1903r1; esomeprazole; famotidine; placebo; famotidine; histamine H2 receptor antagonist; proton pump inhibitor; adult; aged; Article; consensus; constipation; controlled study; demography; diarrhea; disease severity; dizziness; double blind procedure; drug efficacy; drug safety; endoscopy; erosive gastritis; female; follow up; headache; human; major clinical study; male; middle aged; multicenter study; patient compliance; phase 3 clinical trial; population research; randomized controlled trial; sample size; scoring system; self report; young adult; clinical trial; gastritis | English | 2024 | 2024-01 | 10.5009/gnl220446 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Factors Associated with Reaching Mid-Parental Height in Patients Diagnosed with Inflammatory Bowel Disease in Childhood and Adolescent Period | Background/Aims: The recent update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease initiative has added normal growth in children as an intermediate target in Crohn's disease and ulcerative colitis. We aimed to investigate factors associated with reaching mid parental height (MPH) in patients diagnosed with inflammatory bowel disease in childhood and the adolescent period. Methods: This multicenter retrospective observational study included pediatric patients with inflammatory bowel disease that had reached adult height. Factors associated with reaching MPH were investigated by logistic regression analyses. Results: A total of 166 patients were included in this study (128 Crohn's disease and 38 ulcerative colitis). Among them, 54.2% (90/166) had reached their MPH. Multivariable logistic regression analysis revealed that height Z-score at diagnosis and MPH Z-score were independently associated with reaching MPH (odds ratio [OR], 8.45; 95% confidence interval [CI], 4.44 to 17.90; p<0.001 and OR, 0.11; 95% CI, 0.04 to 0.24; p<0.001, respectively). According to the receiver operating characteristic curve analysis, the optimal cutoff level of "height Z-score at diagnosis minus MPH Z-score" that was associated with reaching MPH was -0.01 with an area under the curve of 0.889 (95% CI [0.835 to 0.944], sensitivity 88.9%, specificity 84.2%, positive predictive value 87.0%, negative predictive value 86.5%, p<0.001). Conclusions: Height Z-score at diagnosis and MPH Z-score were the only factors associated with reaching MPH. Efforts should be made to restore growth in pediatric patients who present with a negative "height Z-score at diagnosis minus MPH Z-score." (Gut Liver, Published online August 28, 2023) | Choi, So Yoon; Choi, Sujin; Choe, Byung-Ho; Park, Jae Hong; Choi, Kwang-Hae; Lee, Hae Jeong; Park, Ji Sook; Seo, Ji-Hyun; Kim, Jae Young; Jang, Hyo-Jeong; Hong, Suk Jin; Kim, Eun Young; Lee, Yeoun Joo; Kang, Ben | Kosin Univ, Gospel Hosp, Dept Pediat, Coll Med, Busan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Crohns & Colitis Assoc Daegu Gyeongbuk CCAiD, Daegu, South Korea; Pusan Natl Univ, Coll Med, Yangsan Hosp, Dept Pediat, Yangsan, South Korea; Yeungnam Univ, Dept Pediat, Sch Med, Daegu, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Pediat, Sch Med, Chang Won, South Korea; Gyeongsang Natl Univ Hosp, Dept Pediat, Jinju, South Korea; Gyeongsang Natl Univ, Dept Pediat, Changwon Hosp, Chang Won, South Korea; Keimyung Univ, Dept Pediat, Sch Med, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Dept Pediat, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu, South Korea | ; 康, 奔/JMQ-0812-2023; Kim, Eun Young/JCE-3602-2023; Lee, Yeoun Joo/AGP-1813-2022; Choe, Byung-Ho/KSM-6251-2024 | 57207282105; 57223972405; 57574977300; 57202928590; 55040976900; 35722209100; 35485228600; 55712045100; 57203251636; 55355948500; 56573097000; 58889004100; 34877162300; 57194823199 | moonmissing@gmail.com;benkang@knu.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 18 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.2 | 35.7 | 1.07 | 2025-04-16 | 1 | 2 | Inflammatory bowel disease; Crohn disease; Ulcerative colitis; Height; Child | PEDIATRIC CROHNS-DISEASE; ADULT HEIGHT; GROWTH; CHILDREN; THERAPY; IMPROVEMENT; LESIONS; ONSET | Child; Crohn disease; Height; Inflammatory bowel disease; Ulcerative colitis | Adolescent; Adult; Child; Colitis, Ulcerative; Crohn Disease; Humans; Inflammatory Bowel Diseases; Parents; Retrospective Studies; C reactive protein; calgranulin; serum albumin; adolescent; age; Article; body height; childhood; Crohn disease; disease duration; erythrocyte sedimentation rate; female; follow up; hematocrit; human; inflammatory bowel disease; leukocyte count; major clinical study; male; observational study; phenotype; platelet count; predictive value; receiver operating characteristic; retrospective study; sensitivity and specificity; ulcerative colitis; adult; child; child parent relation; clinical trial; Crohn disease; inflammatory bowel disease; multicenter study; ulcerative colitis | English | 2024 | 2024-01 | 10.5009/gnl220421 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Fecal Calprotectin at Postinduction Is Capable of Predicting Persistent Remission and Endoscopic Healing after 1 Year of Treatment with Infliximab in Pediatric Patients with Crohn's Disease | Background/Aims: The recent update on Selecting Therapeutic Targets in Inflammatory Bowel Disease initiative has added a decrease in fecal calprotectin (FC) to an acceptable range as an intermediate target for Crohn's disease (CD). We aimed to investigate whether postinduction FC could predict future persistent remission (PR) and endoscopic healing (EH) after 1 year of treatment with infliximab (IFX) in pediatric patients with CD. Methods: This multicenter retrospective observational study included pediatric patients with CD who were followed up for at least 1 year after starting IFX. The association of postinduction FC with PR and EH was investigated. Results: A total of 132 patients were included in this study. PR and EH were observed in 71.2% (94/132) and 73.9% (82/111) of the patients, respectively. In multivariate logistic regression analysis, only the postinduction FC level was associated with PR (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.08 to 0.66; p=0.009). The FC levels at initiation of IFX and postinduction were significantly associated with EH (OR, 0.73; 95% CI, 0.53 to 0.99; p=0.044 and OR, 0.20; 95% CI, 0.06 to 0.49; p=0.002, respectively). According to the receiver operating characteristic curve analysis, the optimal cutoff level for postinduction FC associated with PR was 122 mg/kg, and that associated with EH was 377 mg/kg. Conclusions: Postinduction FC was associated with PR and EH after 1 year of treatment with IFX in pediatric patients with CD. Our findings emphasize the importance of FC as an intermediate target in the treat-to-target era. (Gut Liver, Published online November 28, 2023) | Lee, Yoo Min; Kim, Eun Sil; Choi, Sujin; Jang, Hyo-Jeong; Kim, Yu Bin; Choi, So Yoon; Choe, Byung-Ho; Kang, Ben | Soonchunhyang Univ, Coll Med, Bucheon Hosp, Dept Pediat, Bucheon, South Korea; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Pediat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Crohns & Colitis Assoc Daegu Gyeongbuk CCAiD, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Pediat, Daegu, South Korea; Ajou Univ, Med Ctr, Dept Pediat, Suwon, South Korea; Kosin Univ, Coll Med, Dept Pediat, Gospel Hosp, Pusan, South Korea | ; Kim, Youngmin/C-7926-2019; 康, 奔/JMQ-0812-2023; Lee, Yong Jae/GLR-4153-2022; Choe, Byung-Ho/KSM-6251-2024 | 55588928200; 57205500267; 57223972405; 55355948500; 57212382905; 57207282105; 57574977300; 57194823199 | benkang@knu.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 18 | 3 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.2 | 35.7 | 0 | 2025-04-16 | 0 | 0 | Crohn disease; Calprotectin; Infliximab; Prognosis | INFLAMMATORY-BOWEL-DISEASE; INDUCTION THERAPY; RELAPSE; CHILDREN; MULTICENTER; MARKER; PARAMETERS; MANAGEMENT; DIAGNOSIS; CRP | Calprotectin; Crohn disease; Infliximab; Prognosis | Adolescent; Biomarkers; Child; Crohn Disease; Feces; Female; Gastrointestinal Agents; Humans; Infliximab; Leukocyte L1 Antigen Complex; Logistic Models; Male; Predictive Value of Tests; Remission Induction; Retrospective Studies; Treatment Outcome; adalimumab; azathioprine; calgranulin; infliximab; tumor necrosis factor inhibitor; biological marker; calgranulin; gastrointestinal agent; adolescent; adult; Article; controlled study; Crohn disease; drug efficacy; drug targeting; endoscopic healing; feces level; female; follow up; healing; human; ileocolonoscopy; intestine resection; major clinical study; male; observational study; outcome assessment; persistent remission; prognosis; reference value; remission; retrospective study; treatment duration; treatment response; chemistry; child; clinical trial; Crohn disease; feces; multicenter study; predictive value; statistical model; treatment outcome | English | 2024 | 2024-05 | 10.5009/gnl230022 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Local Ablation for Hepatocellular Carcinoma: 2024 Expert Consensus-Based Practical Recommendations of the Korean Liver Cancer Association | Local ablation for hepatocellular carcinoma, a non-surgical option that directly targets and destroys tumor cells, has advanced significantly since the 1990s. Therapies with different energy sources, such as radiofrequency ablation, microwave ablation, and cryoablation, employ different mechanisms to induce tumor necrosis. The precision, safety, and effectiveness of these therapies have increased with advances in guiding technologies and device improvements. Consequently, local ablation has become the first-line treatment for early-stage hepatocellular carcinoma. The lack of organized evidence and expert opinions regarding patient selection, preprocedure preparation, procedural methods, swift post-treatment evaluation, and follow-up has resulted in clinicians following varied practices. Therefore, an expert consensus-based practical recommendation for local ablation was developed by a group of experts in radiology and hepatology from the Research Committee of the Korean Liver Cancer Association in collaboration with the Korean Society of Image-Guided Tumor Ablation to provide useful information and guidance for performing local ablation and for the pre- and post-treatment management of patients. | Han, Seungchul; Sung, Pil Soo; Park, Soo Young; Kim, Jin Woong; Hong, Hyun Pyo; Yoon, Jung-Hee; Chung, Dong Jin; Kwon, Joon Ho; Lim, Sanghyeok; Kim, Jae Hyun; Shin, Seung Kak; Kim, Tae Hyung; Lee, Dong Ho; Choi, Jong Young | Samsung Med Ctr, Dept Radiol, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Coll Med, Dept Internal Med, Daegu, South Korea; Chosun Univ, Chosun Univ Hosp, Coll Med, Dept Radiol, Gwangju, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Radiol, Seoul, South Korea; Inje Univ, Haeundae Paik Hosp, Coll Med, Dept Radiol, Busan, South Korea; Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Radiol, Seoul, South Korea; Yonsei Univ, Severance Hosp, Res Inst Radiol Sci, Dept Radiol,Coll Med, Seoul, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Radiol, Coll Med, Bucheon, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Radiol, Seoul, South Korea; Gachon Univ, Coll Med, Gil Med Ctr, Dept Internal Med, Incheon, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Anyang, South Korea | ; Kim, I Tae/L-9051-2013; Kim, JaeHyun/AAA-9293-2021; Sung, Pil/K-2072-2019 | 57205345915; 57206341074; 57191674344; 57196169638; 22834834700; 55705048800; 7401719231; 55206691900; 55842755400; 57211596138; 57219944778; 57755913500; 57222878418; 57203732617 | dhlee.rad@gmail.com; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 18 | 5 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.2 | 35.7 | 0 | 2025-05-07 | 1 | 0 | Guideline; Hepatocellular carcinoma; Local ablation; Practical recommendation | PERCUTANEOUS RADIOFREQUENCY ABLATION; RANDOMIZED CONTROLLED-TRIAL; CONTRAST-ENHANCED ULTRASONOGRAPHY; THERMAL ABLATION; ANTIBIOTIC-PROPHYLAXIS; POOR CONSPICUOUSNESS; ARTIFICIAL ASCITES; HEPATIC-TUMORS; CRYOABLATION; COMPLICATIONS | Guideline; Hepatocellular carcinoma; Local ablation; Practical recommendation | Ablation Techniques; Carcinoma, Hepatocellular; Catheter Ablation; Consensus; Humans; Liver Neoplasms; Patient Selection; Radiofrequency Ablation; Republic of Korea; adult; consensus; cryoablation; drug therapy; energy resource; evaluation and follow up; first-line treatment; human; liver cancer; liver cell carcinoma; microwave thermotherapy; patient selection; radiofrequency ablation; review; therapy; tumor ablation; tumor necrosis; ablation therapy; catheter ablation; liver tumor; practice guideline; procedures; South Korea; surgery | English | 2024 | 2024-09 | 10.5009/gnl240350 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Metabolomic Profiles in Patients with Cervical Cancer Undergoing Cisplatin and Radiation Therapy | This study was aimed to evaluate endogenous metabolic changes before and after cisplatin and radiation therapy in patients with cervical cancer via untargeted metabolomic analysis using plasma samples. A total of 13 cervical cancer patients were enrolled in this study. Plasma samples were collected from each patient on two occasions: approximately one week before therapy (P1) and after completion of cisplatin and radiation therapy (P2). Of the 13 patients, 12 patients received both cisplatin and radiation therapy, whereas one patient received radiation therapy alone. The samples were analyzed using the Ultimate 3000 coupled with Q ExactiveTM Focus Hybrid Quadrupole-OrbitrapTM mass spectrometry (Thermo Fisher Scientific, Waltham, MA, USA). Chromatographic separation utilized a Kinetex C18 column 2.1x100 mm (2.6 mu m) (Phenomenex, Torrance, CA, USA), and the temperature was maintained at 40 degrees C. Following P2, there were statistically significant increases in the concentrations of indoxyl sulfate, phenylacetylglutamine, Lysophosphatidyethanolamine (LysoPE) (18:1), and indole-3-acetic acid compared with the concentrations observed at P1. Specifically, in the human papillomavirus (HPV) noninfection group, indoxyl sulfate, LysoPE (18:1), and phenylacetylglutamine showed statistically significant increases at P2 compared with P1. No significant changes in metabolite concentrations were observed in the HPV infection group. Indoxyl sulfate, LysoPE (18:1), phenylacetylglutamine, and indole-3-acetic acid were significantly increased following cisplatin and radiation therapy. | Choi, Seo-Yeon; Kim, Suin; Jeon, Ji-Young; Kim, Min-Gul; Lee, Sun-Young; Shin, Kwang-Hee | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Jeonbuk Natl Univ Hosp, Ctr Clin Pharmacol, Jeonju 54907, South Korea; Jeonbuk Natl Univ, Sch Med, Dept Pharmacol, Jeonju 54907, South Korea; Jeonbuk Natl Univ, Res Inst Clin Med, Jeonbuk Natl Univ Hosp, Biomed Res Inst, Jeonju 54907, South Korea; Jeonbuk Natl Univ, Sch Med, Dept Radiat Oncol, Jeonju 561712, South Korea | 58966816100; 58772649700; 55425864700; 38260938400; 57203597345; 35216279300 | sylee78@jbnu.ac.kr;kshin@knu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 32 | 3 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3.2 | 35.7 | 0 | 2025-05-07 | 0 | 0 | Cervical cancer; Metabolomics; Cisplatin; Biomarker | MECHANISMS; BIOMARKER; PATHWAYS; RNA; HPV | Biomarker; Cervical cancer; Cisplatin; Metabolomics | alanine; alanine aminotransferase; aspartate aminotransferase; cisplatin; creatinine; donepezil; erythropoietin; lysophosphatidyethanolamine; phenylacetylglutamine; threonine; unclassified drug; adult; aged; Article; cancer radiotherapy; clinical article; controlled study; density gradient centrifugation; discriminant analysis; electrospray; female; glomerulus filtration rate; high performance liquid chromatography; human; limit of quantitation; liquid chromatography-mass spectrometry; mass fragmentography; mass spectrometry; metabolomics; papillomavirus infection; receiver operating characteristic; ultra performance liquid chromatography; uterine cervix cancer | English | 2024 | 2024-05 | 10.4062/biomolther.2023.159 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Morroniside Protects C2C12 Myoblasts from Oxidative Damage Caused by ROS-Mediated Mitochondrial Damage and Induction of Endoplasmic Reticulum Stress | Oxidative stress contributes to the onset of chronic diseases in various organs, including muscles. Morroniside, a type of iridoid glycoside contained in Cornus officinalis, is reported to have advantages as a natural compound that prevents various diseases. However, the question of whether this phytochemical exerts any inhibitory effect against oxidative stress in muscle cells has not been well reported. Therefore, the current study aimed to evaluate whether morroniside can protect against oxidative damage induced by hydrogen peroxide (H2O2) in murine C2C12 myoblasts. Our results demonstrate that morroniside pretreatment was able to inhibit cytotoxicity while suppressing H2O2-induced DNA damage and apoptosis. Morroniside also significantly improved the antioxidant capacity in H2O2-challenged C2C12 cells by blocking the production of cellular reactive oxygen species and mitochondrial superoxide and increasing glutathione production. In addition, H2O2-induced mitochondrial damage and endoplasmic reticulum (ER) stress were effectively attenuated by morroniside pretreatment, inhibiting cytoplasmic leakage of cytochrome c and expression of ER stress -related proteins. Furthermore, morroniside neutralized H2O2-mediated calcium (Ca2+) overload in mitochondria and mitigated the expression of calpains, cytosolic Ca2+-dependent proteases. Collectively, these findings demonstrate that morroniside protected against mitochondrial impairment and Ca2+-mediated ER stress by minimizing oxidative stress, thereby inhibiting H2O2-induced cytotoxicity in C2C12 myoblasts. | Hwangbo, Hyun; Park, Cheol; Bang, Eunjin; Kim, Hyuk Soon; Bae, Sung-Jin; Kim, Eunjeong; Jung, Youngmi; Leem, Sun-Hee; Seo, Young Rok; Hong, Su Hyun; Kim, Gi-Young; Hyun, Jin Won; Choi, Yung Hyun | Dong Eui Univ, Coll Korean Med, Dept Biochem, Basic Res Lab Regulat Microplast Mediated Dis, Busan 47340, South Korea; Dong Eui Univ, Coll Liberal Studies, Dept Div Basic Sci, Busan 47340, South Korea; Dong A Univ, Coll Nat Sci, Grad Sch, Dept Biomed Sci, Busan 49315, South Korea; Dong A Univ, Grad Sch, Dept Hlth Sci, Busan 49315, South Korea; Kosin Univ, Coll Med, Dept Mol Biol & Immunol, Busan 49267, South Korea; Kyungpook Natl Univ, Coll Natl Sci, Sch Life Sci, Plus KNU Creat Biores Grp BK21, Daegu 41566, South Korea; Pusan Natl Univ, Coll Nat Sci, Dept Biol Sci, Busan 46241, South Korea; Dongguk Univ Biomed Campus, Inst Environm Med, Dept Life Sci, Goyang 10326, South Korea; Jeju Natl Univ, Dept Marine Life Sci, Lab Immunobiol, Jeju 63243, South Korea; Jeju Natl Univ, Coll Med, Dept Biochem, Jeju 63243, South Korea; Jeju Natl Univ, Jeju Res Ctr Nat Med, Jeju 63243, South Korea | Kim, Hyuk Soon/IQW-9348-2023; Bae, Sung-Jin/AAX-9144-2021 | 57201497483; 7408418079; 57200299991; 35770880400; 57199938696; 56892981600; 16238452900; 7004204972; 7402001374; 37030297500; 59130435000; 35233601800; 57211727369 | choiyh@deu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 32 | 3 | SCIE | PHARMACOLOGY & PHARMACY | 2024 | 3.2 | 35.7 | 3.25 | 2025-05-07 | 9 | 10 | Morroniside; Oxidative stress; Mitochondrial damage; ER stress; Ca2+ | CORNUS-OFFICINALIS; HYDROGEN-PEROXIDE; ER STRESS; APOPTOSIS; ACTIVATION; LOGANIN; FRUCTUS | Ca<sup>2+</sup>; ER stress; Mitochondrial damage; Morroniside; Oxidative stress | beta actin; calpain 1; calpain 2; caspase 3; cyclooxygenase 4; cytochrome c; dimethyl sulfoxide; endoplasmic reticulum chaperone BiP; endoplasmic reticulum kinase; gamma h2ax protein; growth arrest and DNA damage inducible protein 153; histone; hydrogen peroxide; iridoid; lactate dehydrogenase; Morroniside; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1; prostaglandin synthase; protein Bax; protein bcl 2; reactive oxygen metabolite; unclassified drug; animal cell; animal experiment; animal model; apoptosis; Article; C2C12 cell line; cell damage; cell death; cell viability; controlled study; disorders of mitochondrial functions; DNA damage; DNA fragmentation assay; endoplasmic reticulum stress; fluorescence microscopy; immunoblotting; immunofluorescence; mitochondrion; mouse; MTT assay; nonhuman; oxidative stress; protein expression; Western blotting | English | 2024 | 2024-05 | 10.4062/biomolther.2024.012 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Outcomes of Palliative Chemotherapy for Ampulla of Vater Adenocarcinoma: A Multicenter Cohort Study | Background/Aims: Palliative chemotherapy (PC) is not standardized for patients with advanced ampulla of Vater adenocarcinoma (AA). This multicenter, retrospective study evaluated first-line PC outcomes in patients with AA. Methods: Patients diagnosed with AA between January 2010 and December 2020 who underwent PC were enrolled from 10 institutions. Overall survival (OS) and progression-free survival (PFS) according to the chemotherapy regimen were analyzed. Results: Of 255 patients (mean age, 64.0 +/- 10.0 years; male, 57.6%), 14 (5.5%) had locally advanced AA and 241 (94.5%) had metastatic AA. Gemcitabine plus cisplatin (GP) was administered as first-line chemotherapy to 192 patients (75.3%), whereas capecitabine plus oxaliplatin (CAPOX) was administered to 39 patients (15.3%). The median OS of all patients was 19.8 months (95% confidence interval [CI], 17.3 to 22.3), and that of patients who received GP and CAPOX was 20.4 months (95% CI, 17.2 to 23.6) and 16.0 months (95% CI, 11.2 to 20.7), respectively. The median PFS of GP and CAPOX patients were 8.4 months (95% CI, 7.1 to 9.7) and 5.1 months (95% CI, 2.5 to 7.8), respectively. PC for AA demonstrated improved median outcomes in both OS and PFS compared to conventional bile duct cancers that included AA. Conclusions: While previous studies have shown mixed prognostic outcomes when AA was analyzed together with other biliary tract cancers, our study unveils a distinct clinical prognosis specific to AA on a large scale with systemic anticancer therapy. These findings suggest that AA is a distinct type of tumor, different from other biliary tract cancers, and AA itself could be expected to have a favorable response to PC. (Gut Liver, Published online December 22, 2023) | Jang, Dong Kee; Kim, So Jeong; Chung, Hwe Hoon; Lee, Jae Min; Yoon, Seung Bae; Lee, Jong-Chan; Shin, Dong Woo; Hwang, Jin-Hyeok; Jung, Min Kyu; Lee, Yoon Suk; Lee, Hee Seung; Park, Joo Kyung | Seoul Natl Univ, Seoul Metropolitan Govt, Dept Internal Med, Coll Med,Boramae Med Ctr, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Div Gastroenterol, Coll Med, Seoul, South Korea; Ewha Womans Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Internal Med, Div Gastroenterol,Sch Med, Suwon, South Korea; Korea Univ, Dept Internal Med, Anam Hosp, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Coll Med, Seongnam, South Korea; Hallym Univ, Coll Med, Hallym Univ Sacred Heart Hosp, Dept Internal Med, Anyang, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Gastroenterol, Daegu, South Korea; Inje Univ, Ilsan Paik Hosp, Dept Internal Med, Div Gastroenterol,Coll Med, Goyang, South Korea | ; Kim, Seong Cheol/ABD-1493-2022; Lee, Jong-Chan/AAJ-2401-2020; LEE, Yoon-Suk/D-1827-2019; Lee, Yoon Suk/D-1827-2019; Kim, Young/J-5414-2012 | 56091787300; 57216220912; 57385382500; 8636426500; 35217323900; 57215674737; 56258304500; 35200778600; 56783168100; 57219432560; 57278859200; 57203537385 | mdsophie@gmail.com;lhs6865@yuhs.ac; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 18 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.2 | 35.7 | 0.48 | 2025-05-07 | 1 | 1 | Ampulla of Vater; Biliary tract neoplasms; Chemotherapy; Survival | BILIARY-TRACT CANCER; INTESTINAL-TYPE; SMALL-BOWEL; OPEN-LABEL; CARCINOMA; GEMCITABINE; OXALIPLATIN; SURVIVAL; COMBINATION; CISPLATIN | Ampulla of Vater; Biliary tract neoplasms; Chemotherapy; Survival | Adenocarcinoma; Aged; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cisplatin; Common Bile Duct Neoplasms; Deoxycytidine; Female; Gemcitabine; Humans; Male; Middle Aged; Oxaliplatin; Palliative Care; Progression-Free Survival; Retrospective Studies; Treatment Outcome; capecitabine; cisplatin; gemcitabine; oxaliplatin; antineoplastic agent; capecitabine; cisplatin; doxecitine; gemcitabine; oxaliplatin; adult; Article; cancer chemotherapy; cancer growth; cancer palliative therapy; cancer prognosis; cancer recurrence; cancer survival; cohort analysis; female; gastrointestinal metastasis; human; major clinical study; male; metastatic ampulla of vater adenocarcinoma; middle aged; outcome assessment; overall survival; progression free survival; treatment response; Vater papilla carcinoma; adenocarcinoma; aged; ampulla of Vater; bile duct tumor; clinical trial; drug therapy; mortality; multicenter study; palliative therapy; pathology; procedures; retrospective study; treatment outcome | English | 2024 | 2024-07 | 10.5009/gnl230164 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Phenol Photostatic Spectra and Quantum-Classical Photodynamic Deprotonation | The spectral-luminescence properties and photochemical conversions of phenol were analyzed for an isolated molecule as well as in water solvents in a continuum implicit model and explicit atomistic surroundings. This involved employing cut-edge hybrid quantum-classical methodologies to generate static optical spectra and the excited dissipative crossing potential energy curves. A combination of electronic excitations, gradient calculations, and embedding electrostatic potential fitting charges on quantum-classical molecular dynamic propagation trajectories provided statistically averaged absorption spectra. The mixed-reference spin-flip multiconfigurational linear response method based on reference triplet preprocessed in the time-dependent density-functional theory was utilized to determine conical intersections between the lowest excited and ground states, as well as two-stage transitions from the second excitation to the ground state. Non-adiabatic quantum-classical molecular dynamics defined photodissipative trajectories of excited states, their lifetimes, and crossing points through trajectory surface hopping together with the mixed-reference spin-flip and embedding electrostatic potential fitting approaches. Dyson orbitals of the extended Koopmans' theorem were applied to reveal the nature of molecular states at conical intersections and key points on photodynamic trajectories. Potential hydroxyl group cleavage predicted with conical intersections searching turns to "swift" O-H deprotonation through |pi ->sigma(OH)*> transition along photodynamic propagations in contrast with "long" processes leading to benzene ring deformation with stable O-H bond. | Pomogaev, Vladimir; Bocharnikova, Elena; Tchaikovskaya, Olga; Avramov, Pavel | Natl Res Tomsk State Univ, Dept Phys, Lab Photophys & Photochem Mol, Tomsk, Russia; St Petersburg State Univ, St Petersburg, Russia; Russian Acad Sci, Inst Electrophys, Ural Branch, Ekaterinburg, Russia; Kyungpook Natl Univ, Dept Chem, Daegu, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu, South Korea | Pomogaev, Vladimir/E-5049-2014 | 6603016010; 57208567909; 57997675500; 7004322420 | valienpo@yandex.ru;paul.veniaminovich@knu.ac.kr; | INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY | INT J QUANTUM CHEM | 0020-7608 | 1097-461X | 124 | 21 | SCIE | CHEMISTRY, PHYSICAL;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL;QUANTUM SCIENCE & TECHNOLOGY | 2024 | 2 | 35.7 | 0 | 2025-05-07 | 1 | 1 | absorption spectra; conical intersection; MRSF methodology; phenol; quantum-classical photodynamic; TD-DFT | SET MODEL CHEMISTRY; TOTAL ENERGIES; DYNAMICS; ULTRAFAST; STATE; GRADIENT; ATOMS | absorption spectra; conical intersection; MRSF methodology; phenol; quantum-classical photodynamic; TD-DFT | Absorption spectra; Molecules; Quantum optics; Classical molecular dynamics; Conical intersection; Electrostatic potentials; Embeddings; MRSF methodology; Quantum-classical; Quantum-classical photodynamic; Spectra's; Spin flip; TD-DFT; Deprotonation | English | 2024 | 2024-11-05 | 10.1002/qua.27504 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: