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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Secure Healthcare Record Sharing Mechanism with Blockchain | The transfer of information is a demanding issue, particularly due to the presence of a large number of eavesdroppers on communication channels. Sharing medical service records between different clinical jobs is a basic and testing research topic. The particular characteristics of blockchains have attracted a large amount of attention and resulted in revolutionary changes to various business applications, including medical care. A blockchain is based on a distributed ledger, which tends to improve cyber security. A number of proposals have been made with respect to the sharing of basic medical records using a blockchain without needing earlier information or the trust of patients. Specialist service providers and insurance agencies are not secure against data breaches. The safe sharing of clinical records between different countries, to ensure an incorporated and universal medical service, is also a significant issue for patients who travel. The medical data of patients normally reside on different healthcare units around the world, thus raising many concerns. Firstly, a patient's history of treatment by different physicians is not accessible to the doctor in a single location. Secondly, it is very difficult to secure widespread data residing in different locations. This study proposed record sharing in a chain-like structure, in which every record is globally connected to the others, based on a blockchain under the suggestions and recommendations of the HL7 standards. This study focused on making medical data available, especially of patients who travel in different countries, for a specific period of time after validating the required authentication. Authorization and authentication are performed on the Shibboleth identity management system with the involvement of patient in the sanction process, thereby revealing the patient data for the specific period of time. The proposed approach improves the performance with respect to other record sharing systems, e.g., it reduces the time to read, write, delete, and revoke a record by a noticeable margin. The proposed system takes around three seconds to upload and 7.5 s to download 250 Mb of data, which can contain up to sixteen documents, over a stable network connection. The system has a latency of 413.76 ms when retrieving 100 records, compared to 447.9 and 459.3 ms in previous systems. Thus, the proposed system improved the performance and ensured seclusion by using a blockchain. | Butt, Ghulam Qadar; Sayed, Toqeer Ali; Riaz, Rabia; Rizvi, Sanam Shahla; Paul, Anand | Univ Azad Jammu & Kashmir, Dept CS&IT, Muzaffarabad 13100, Pakistan; Islamic Univ Madinah, Fac Comp & Informat Syst, Madinah 42351, Saudi Arabia; Raptor Interact Pty Ltd, Eco Blvd,Witch Hazel Ave, ZA-0157 Gauteng, South Africa; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 37224, South Korea | ; Riaz, Rabia/HJI-6429-2023; Paul, Anand/V-6724-2017; Syed, Toqeer/KLZ-7770-2024; Rizvi, Sanam Shahla/GQQ-8390-2022 | 57469761000; 57469282000; 24475180100; 25927493500; 56650522400 | ghulamqadir90@gmail.com;toqeer@iu.edu.sa;rabia.riaz@ajku.edu.pk;sanam.shahla@raptorinteractive.com;paul.editor@gmail.com; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 12 | 5 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2022 | 2.7 | 46.1 | 2.97 | 2025-06-25 | 21 | 35 | blockchain; cyber-security; medical services; cyber-attacks; data communication; distributed ledger; identity management; RAFT; HL7; electronic health record; Hyperledger Composer | PRIVACY | Blockchain; Cyber-attacks; Cyber-security; Data communication; Distributed ledger; Electronic health record; HL7; Hyperledger Composer; Identity management; Medical services; RAFT | English | 2022 | 2022-03 | 10.3390/app12052307 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Simulation of the Rollover Angle of a Self-Propelled Radish Harvester for Different Load Conditions | This study was focused on the stability analysis of the self-propelled radish harvester. A 3D simulation model was developed using RecurDyn and used to analyze the rollover angle. The rollover angle of the original radish harvester was analyzed and checked to see if it satisfied the standard overturning angle (i.e., 30 degrees). To improve it, three simulated weights (50, 100, and 150 kg) were added to three positions (front, center, and rear). The rollover angle of the radish harvester was slightly less than the criterion angle at a deflection angle of 180 degrees. This issue was solved by attaching an additional weight to the front with a deflection angle of 180 degrees. In particular, when an additional weight of 50 kg was attached to the front or an additional weight of 150 kg was attached to the center or rear, the criterion angle range satisfied all conditions. In conclusion, it is feasible that the self-propelled radish harvester prototype could satisfy the criterion angle with the additional load and could be applied to field agriculture. | Kim, Wan-Soo; Siddique, Md Abu Ayub; Kim, Yong-Joo; Jung, Yeon-Jun; Baek, Seung-Min; Baek, Seung-Yun; Kim, Yeon-Soo; Lim, Ryu-Gap | Kyungpook Natl Univ, Dept Bioind Machinery Engn, Daegu 41566, South Korea; Chungnam Natl Univ, Dept Agr Machinery Engn, Daejeon 34134, South Korea; Chungnam Natl Univ, Dept Smart Agr Syst, Daejeon 34134, South Korea; Aerzen Turbo Co Ltd, R&D Team, Sejong 30077, South Korea; Korea Inst Ind Technol KITECH, Smart Agr Machinery R&D Grp, Gimje 54325, South Korea; Korea Agr Technol Promot Agcy, Innovalley Sustantiat Team, Sangju 37127, South Korea | ; Kim, Yong-Joo/AAK-1840-2021; Siddique, PhD, Md. Abu Ayub/AAB-6607-2021 | 57192918810; 57192431042; 57204759454; 57197853993; 57204040500; 57216612175; 57192923355; 57216499874 | babina@cnu.ac.kr;limso@koat.or.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 12 | 21 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2022 | 2.7 | 46.1 | 0.87 | 2025-06-25 | 9 | 10 | radish harvester; rollover angle; stability; tilt angle; deflection angle; simulation | TRACTOR; MODEL; PREDICTION; DYNAMICS | deflection angle; radish harvester; rollover angle; simulation; stability; tilt angle | English | 2022 | 2022-11 | 10.3390/app122110733 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Soil Classification from Piezocone Penetration Test Using Fuzzy Clustering and Neuro-Fuzzy Theory | The advantage of the piezocone penetration test is a guarantee of continuous data, which are a source of reliable interpretation of the target soil layer. Much research has been carried out for several decades, and several classification charts have been developed to classify in situ soil from the cone penetration test result. Even though most present classification charts or methods were developed on the basis of data which were compiled over many countries, they should be verified to be feasible for local country. However, unfortunately, revision of those charts is quite difficult or almost impossible even though a chart provides misclassified soil class. In this research, a new method for developing soil classification model is proposed by using soft computing theory-fuzzy C-mean clustering and neuro-fuzzy theory-as a function of 5173 piezocone penetration test (PCPT) results and soil boring logs compiled from 17 local sites around Korea. Feasibility of the proposed soil classification model was verified from the viewpoint of accuracy of the classification result by comparing the classification results not only for data which were used for developing the model but also new data, which were not included in developing the model with real boring logs, other fuzzy computing classification models, and Robertson's charts. The biggest advantage of the proposed method is that it is easy to make the piezocone soil classification system more accurate by updating new data. | Moon, Joon-Shik; Kim, Chan-Hong; Kim, Young-Sang | Kyungpook Natl Univ, Dept Civil Engn, Daegu 41566, South Korea; Korea Mine Rehabil & Mineral Resources Corp, Wonju 26464, South Korea; Chonnam Natl Univ, Dept Civil Engn, Gwangju 61186, South Korea | Kim, Young-Sang/D-5083-2014 | 57149572000; 57656299000; 55699617000 | orangedreamer@gmail.com;chahkim@komir.or.kr;geoyskim@jnu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 12 | 8 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2022 | 2.7 | 46.1 | 0.17 | 2025-06-25 | 2 | 2 | piezocone; soil classification; fuzzy C-means clustering; neuro-fuzzy | fuzzy C-means clustering; neuro-fuzzy; piezocone; soil classification | English | 2022 | 2022-04 | 10.3390/app12084023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The Efficacy, Phytotoxicity, and Safety of Liquid Ethyl Formate Used to Control the Grape (Campbell Early) Quarantine Pest Pseudococcus comstocki | Featured Application Pseudococcus comstocki, a quarantine pest, was completely killed when fumigated with liquid ethyl formate (EF), without any phototoxicity or alterations in the internal condition of the grapes (Campbell Early), at EF 70 g/m(3) for 4 h, 145.85 g h/m(3) with a loading ratio of 10% at 5 degrees C. EF can be an alternative to methyl bromide (MB) in terms of safety in the workplace as well as preventing ozone depletion. Mealybugs found on grapes during quarantine in Korea are fumigated with methyl bromide (MB). However, MB is an ozone-depleting, highly toxic pesticide; therefore, the International Plant Protection Convention, a representative organization involved in quarantine, recommends using MB alternatives. We evaluated the feasibility of using liquid ethyl formate (EF), a new EF formulation, to control mealybugs (Pseudococcus comstocki) on grapes (Campbell Early). Large-scale tests and the comparative evaluation of EF and MB desorption from grapes were conducted during the simulated 72-h post-fumigation period. Dose-response tests showed that the EF concentration and time product causing 99% mortality (LCt(99)) at 5 degrees C was 47.36 and 145.85 g h/m(3) for adults and eggs, respectively. EF treatment at 70 g/m(3) for 4 h at 5 degrees C with a loading ratio of 10% achieved an LCt(99) of 145.85 g h/m(3) on P. comstocki, confirming EF efficacy on mealybugs without phytotoxic effects on grapes. EF fumigation may also be safer because EF concentrations were maintained at less than 100 ppm, the specified exposure limit of EF; meanwhile, those of MB were higher than the exposure limit (1 ppm). Therefore, liquid EF can be used as a safer alternative to MB in phytosanitary treatments of grapes to control P. comstocki. | Lee, Byung-Ho; Hong, Ki-Jeong; Park, Min-Goo | Kyungpook Natl Univ, Inst Qual & Safety Evaluat Agr Prod, Daegu 41566, South Korea; Sunchon Univ, Dept Plant Med, 255 Jungang Ro, Sunchon 57922, South Korea; Jeonbuk Natl Univ, Dept Bioenvironm Chem, Jeonju 54896, South Korea | Park, Min-Goo/AAV-5273-2020 | 57202841615; 33067733500; 57213595173 | pmg@korea.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 12 | 19 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2022 | 2.7 | 46.1 | 0.61 | 2025-06-25 | 7 | 7 | ethyl formate; post-fumigation safety; pest control; sorption rate; mealybug | METHYL-BROMIDE; TETRANYCHUS-URTICAE; FUMIGATION; PHOSPHINE; COMBINATION | ethyl formate; mealybug; pest control; post-fumigation safety; sorption rate | English | 2022 | 2022-10 | 10.3390/app12199769 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Unified Evolutionary Algorithm Framework for Hybrid Power Converter | A significant amount of the literature is focused on converters that supply the required voltage with low input-current ripple to electronic devices. A hybrid converter that combines boost and Cuk converters was developed recently. This hybrid converter achieved a relatively low input-current ripple based on earlier strategies. This paper proposes a new model that simulates a hybrid power converter system using a unified evolutionary algorithm (EA). As part of this paper, we present an improved framework for a hybrid power converter. Moreover, a unified EA is developed to incorporate differential evolution (DE) and genetic algorithm (GA) properties in order to analyze the proposed modified hybrid power converter. This research describes a modified hybrid power converter that optimizes the zero-ripple duty cycle (D-Z) through the proposed algorithm for minimizing the input-current ripple. Based on our simulation results, comparing the proposed method with the baseline algorithm reveals that the proposed approach is significantly more efficient than the baseline algorithm and achieves the minimum input-current ripple in different gain values. In addition, we observe that the proposed algorithm performs better than the DE and GA algorithms in terms of obtaining low input-current ripple results. Therefore, the proposed hybrid algorithm is becoming more efficient with hybridization. | Ghorbanpour, Samira; Seo, Mingyu; Park, Jeong-Ju; Kim, Musu; Jin, Yuwei; Han, Sekyung | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | ; Jin, Yuwei/LIR-2747-2024 | 57207109590; 57215358477; 57964023800; 57963480400; 57212253293; 36023785800 | skhan@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 12 | 21 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2022 | 2.7 | 46.1 | 0.09 | 2025-06-25 | 1 | 1 | power converter; differential evolution; genetic algorithm; unified framework | DIFFERENTIAL EVOLUTION; GENETIC ALGORITHM; OPTIMIZATION; IMPLEMENTATION; DESIGN | differential evolution; genetic algorithm; power converter; unified framework | English | 2022 | 2022-11 | 10.3390/app122111236 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | W-Band Modular Antenna/Detector Array for the Electron Cyclotron Emission Imaging System in KSTAR | A design of a modular antenna/detector array for the electron cyclotron emission (ECE) imaging system at the Korea Superconducting Tokamak Advanced Research (KSTAR) is proposed. The modular antenna/detector array is based on a unit antenna/detector module, which consists of an elliptical mini-lens, a dual-dipole antenna, an antenna balun, a low-noise amplifier, and a metal frame. The proposed modular antenna/detector array resolves the problem in the conventional antenna/detector array where one faulty channel requires the entire array to be removed for the service. With the proposed modular array, each channel module can be easily and independently removed and replaced without interference to the rest of the array, thus minimizing the interrupted service time for maintenance. Moreover, the unit channel modules can be efficiently updated under a variety of the tokamak operation conditions. The antenna/detector modules are optimized to have improved performance, and are tested in a W-band test setup, and consistently provide the gain increase by 10~20 dB as compared with the conventional antenna/detector array. A set of the proposed modular antenna/detector array is currently installed and tested in the KSTAR ECE imaging system, and will consistently produce the improved ECE imaging to monitor MHD instability activities under various plasma operation conditions. | Lee, Gwan Hui; Lee, Jung Seok; Kim, Dong Hwi; Nashuha, Syifa Haunan; Kim, Mun Ju; Min, Byung Cheol; Lee, Jae Hyun; Lee, Woo Chang; Yun, Gun Su; Kim, Tae Gyu; Kim, Bong Tae; Choi, Hyun Chul; Park, Hyeon Keo; In, Yong Kyoon; Kim, Kang Wook | Ulsan Natl Inst Sci & Technol, Ulsan 44919, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Korea Inst Fus Energy, Daejeon 34133, South Korea; Pohang Univ Sci & Technol, Dept Phys, Pohang 37673, South Korea; EM Wise Commun Co, Daegu 41566, South Korea; PEOPLEWORKS Inc, Gumi 39376, South Korea | Lee, Hye/D-9081-2016; Kim, Yong-Tae/HQZ-0240-2023; Lee, Jung-Seok/L-6826-2019; Yun, Gunsu/AGE-6943-2022; In, Yongkyoon/E-5995-2018; Lee, Hyoungjin/GRR-7154-2022 | 57201689364; 57218775544; 56975581300; 57218903778; 57478219300; 39161762500; 57269005100; 57471907200; 8961874500; 57208755321; 57477709900; 57193342681; 56415174700; 8575447100; 57204432422 | gwanhuilee@unist.ac.kr;j.seok1020@gmail.com;eastsine766@gmail.com;nsh11@knu.ac.kr;dranswn@knu.ac.kr;minbc4658@knu.ac.kr;jaehyun@kfe.re.kr;wclee@kfe.re.kr;gunsu@postech.ac.kr;ktg21@em-wise.com;galleryway@peopleworks.co.kr;hcchoi@ee.knu.ac.kr;hyeonpark@unist.ac.kr;inyongkyoon@unist.ac.kr;kang_kim@ee.knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 12 | 5 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2022 | 2.7 | 46.1 | 0.44 | 2025-06-25 | 5 | 6 | modular antenna; detector array; elliptical mini-lens; dual-dipole antenna; wideband antenna balun; maintenance; W-band; ECE; KSTAR | Dual-dipole antenna; ECE; Elliptical mini-lens; KSTAR; Maintenance; Modular antenna/detector array; W-band; Wideband antenna balun | English | 2022 | 2022-03 | 10.3390/app12052431 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Corporate social responsibility and non-GAAP reporting | This study examines the relationship between a firm's corporate social responsibility (CSR) performance and non-GAAP earnings disclosure. I find that firms with good CSR performance (i.e. CSR firms) are more likely to disclose non-GAAP earnings than firms with poor CSR performance (i.e. non-CSR firms). More importantly, I find that CSR firms provide more informative non-GAAP earnings than non-CSR firms. Furthermore, CSR firms' decisions to disclose non-GAAP earnings are less affected by the incentives to meet earnings benchmarks or constraints on other earnings management tools. These findings are consistent with the notion that CSR firms communicate with stakeholders about their sustainable earnings through non-GAAP reporting. | Hwang, Juhee | Kyungpook Natl Univ, Sch Business Adm, 80 Daehak Ro, Daegu 41566, South Korea | 57209750725 | jhhwang10@knu.ac.kr; | APPLIED ECONOMICS | APPL ECON | 0003-6846 | 1466-4283 | 54 | 34 | SSCI | ECONOMICS | 2022 | 2.2 | 46.2 | 0.27 | 2025-06-25 | 3 | 3 | Corporate social responsibility; non-GAAP reporting; voluntary disclosure; earnings management | PRO FORMA; EARNINGS MANAGEMENT; FINANCIAL PERFORMANCE; DISCLOSURE; STREET; INFORMATIVENESS; DETERMINANTS; ADJUSTMENTS; GOVERNANCE | Corporate social responsibility; earnings management; non-GAAP reporting; voluntary disclosure | benchmarking; corporate social responsibility; industrial development; industrial performance; numerical model | English | 2022 | 2022-07-21 | 10.1080/00036846.2021.2017400 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effects of business strategies on the selection of trusted taxpayers: case of South Korea | This study examines the effects of corporate business strategies on the selection of companies as trusted taxpayers in South Korea. The financial policies of companies with a prospector-type business strategy reflect inherent business uncertainties and risks, resulting in overvalued assets and profits and undervalued liabilities and expenses. By contrast, companies adopting a defender-type business strategy tend to accomplish economies of scale through various products and services, resulting in undervalued assets and profits and overvalued liabilities and expenses. Consequently, companies with a prospector-type business strategy are expected to be more likely to be selected as trusted taxpayers than companies using a defender-type business strategy. Our empirical analysis confirms that the probability of selection as a trusted taxpayer increases significantly when the company is a prospector and decreases significantly when the company is a defender. That is, prospector companies have a higher probability of selection as trusted taxpayers due to their aggressive accounting measures, whereas defender companies have a lower probability of selection as trusted taxpayers due to their conservative accounting measures. These findings have implications for tax authorities and executives by illustrating the characteristics required for companies to be selected as trusted taxpayers | Suh, Jung Hwa; Park, Si-Hun | Kyungpook Natl Univ, Sch Business Adm, 210,80 Daehak Ro, Daegu, South Korea; Myongji Univ, Dept Business Adm, Yongin, South Korea | 57489931200; 57489931300 | suzukiyu81@knu.ac.kr; | APPLIED ECONOMICS | APPL ECON | 0003-6846 | 1466-4283 | 54 | 48 | SSCI | ECONOMICS | 2022 | 2.2 | 46.2 | 0.09 | 2025-06-25 | 1 | 1 | Business strategy; prospector; defender; trusted taxpayer; H25; H20 | TAX; POLICY | Business strategy; defender; H20; H25; prospector; trusted taxpayer | South Korea; business development; financial market; financial policy; numerical model; probability; strategic approach; tax system | English | 2022 | 2022-10-14 | 10.1080/00036846.2022.2047603 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Internal and outsourced research and development: are they complements or substitutes? | A theoretically ambiguous relationship exists between internal and outsourced research and development (R&D). Along these lines, previous empirical studies report mixed results regarding the nexus between these two broad forms of R&D activity. Using a firm-level unbalanced panel dataset from South Korea for the period 2006-2018, this study investigates the relationship between internal and outsourced R&D while considering the sunk cost of internal R&D activity and the technology level of firms. We find that the relationship between internal and outsourced R&D depends on the level of industry technology and the size of firms. A complementarity exists between internal and external R&D for larger firms in high-technology industries, while a substitutive relationship is discovered for small and medium-sized firms in medium- and low-technology industries. The results suggest that the complementary or substitutive nature of the relationship between internal and external R&D depends on the industry's technology level and firm size. | Lee, Jaimin; Kim, Minjung | Kyungpook Natl Univ, Dept Int Trade, Daegu, South Korea; Chungnam Natl Univ, Dept Econ, Daejeon 34134, South Korea | Kim, Minjung/MYR-8549-2025 | 56106356700; 57819952700 | kimmj2019@cnu.ac.kr; | APPLIED ECONOMICS | APPL ECON | 0003-6846 | 1466-4283 | 54 | 56 | SSCI | ECONOMICS | 2022 | 2.2 | 46.2 | 0.09 | 2025-06-25 | 1 | 1 | Internal R&D; R&D outsourcing; complement; substitute; technology | PRODUCTIVITY; INVESTMENT; UNCERTAINTY; INNOVATION; COSTS | complement; Internal R&D; R&D outsourcing; substitute; technology | South Korea; data set; econometrics; firm size; panel data; research and development; technological change; technological development | English | 2022 | 2022-12-02 | 10.1080/00036846.2022.2066620 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Safety and Efficacy of Bleomycin Slow Infusion Sclerotherapy Using a Syringe Pump for Microcystic and Mixed Lymphatic Malformations | Purpose To evaluate the safety and efficacy of bleomycin infusion sclerotherapy using a syringe pump in microcystic and mixed (microcystic components with the presence of a cyst over 1 cm) lymphatic malformations (LMs). Materials and Methods Patients who received bleomycin sclerotherapy with a syringe pump for microcystic or mixed LMs were reviewed. Cystic components of LMs were accessed under sonographic guidance, followed by injection of an opacified bleomycin solution using a syringe pump (infusion rate, 10-20 mL/h) under fluoroscopic guidance. Imaging outcomes were graded as complete (> 90% size reduction), partial (25-90%), or no response (< 25%). Clinical outcomes and procedure-related complications were also reviewed. Results Forty-nine patients with 81 sclerotherapies were analyzed. The mean age was 17 years (range 0.1-65 y). Thirty-one (63%) patients had microcystic LMs, and 18 (37%) had mixed. A mean of 1.7 sessions (range 1-4) of sclerotherapy was performed using a mean cumulative dose of bleomycin of 10.8 U (range 1.5-39 U). The mean infusion time was 39 min (range 14-130 min). Regarding imaging outcomes, there was a complete response in 29% (n = 14), a partial response in 57% (n = 28), and no response in 14% (n = 7). Regarding clinical outcomes, there was a complete response in 39% (n = 19), a partial response in 51% (n = 25), and no response in 10% (n = 5). According to the CIRSE classification, no major complications were identified. Conclusions Bleomycin slow infusion sclerotherapy provides gradual filling of sclerosant to target microcystic components. This technique is safe and feasible for the management of microcystic or mixed LMs. | Cha, Jung Guen; Lee, Jongmin; Lee, Sang Yub; Chung, Ho Yun; Lee, Seok Jong; Huh, Seung; Kim, Ji Yoon; Hong, Jihoon | Kyungpook Natl Univ, Sch Med, Dept Radiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, CMRI, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea | Lee, Joong/A-5417-2013; Lee, Joo/C-3851-2013; Lee, Jongmin/AAR-6361-2020 | 57206855971; 55689919700; 56016177400; 7404007181; 56013454400; 7101832929; 57205408095; 57215858314 | lsyrad@gmail.com; | CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY | CARDIOVASC INTER RAD | 0174-1551 | 1432-086X | 45 | 9 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 2.9 | 46.3 | 0.13 | 2025-06-25 | 1 | 1 | Lymphatic malformation; Bleomycin; Infusion; Sclerotherapy; Microcystic | INJECTION; ELECTROSCLEROTHERAPY; COMPLICATIONS | Bleomycin; Infusion; Lymphatic malformation; Microcystic; Sclerotherapy | Adolescent; Adult; Aged; Bleomycin; Child; Child, Preschool; Cysts; Humans; Infant; Lymphatic Abnormalities; Middle Aged; Retrospective Studies; Sclerosing Solutions; Sclerotherapy; Syringes; Treatment Outcome; Young Adult; bleomycin; sclerosing agent; bleomycin; sclerosing agent; adult; Article; case report; child; clinical article; clinical outcome; computer assisted tomography; continuous infusion; coughing; dyspnea; echography; feasibility study; female; fluoroscopy; follow up; human; infusion rate; intracardiac echocardiography; lymphatic malformation; male; microcystic lymphatic malformation; nuclear magnetic resonance imaging; outcome assessment; pain; peroperative complication; radiofrequency ablation; remission; sclerotherapy; skin pigmentation; swelling; urticaria; adolescent; aged; cyst; diagnostic imaging; infant; lymphatic system disease; middle aged; preschool child; procedures; retrospective study; sclerotherapy; syringe; treatment outcome; young adult | English | 2022 | 2022-09 | 10.1007/s00270-022-03224-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Differential expression and sorting of exosomal microRNAs upon activation of the human monocyte-like cell line U937 | Extracellular vesicles such as exosomes in eukaryotes have drawn scrutiny due to their various roles in intercellular communication. Small RNAs, including microRNAs (miRNAs), are more abundant among the cargo of exosomes than other RNA types. MiRNAs loaded in secreted exosomes (or extracellular microRNAs) can be transported to recipient cells and may play a regulatory role although the miRNA loading (or sorting) mechanism in exosomes has not been clearly elucidated. Therefore, this study analyzed exosomal miRNA sequencing data from human myeloid U937 cells treated with phorbol 12-myristate 13-acetate (PMA) and compared it with data from PMA-untreated U937 cells. MiR-24 was highly expressed in the cytoplasm and exosomes of PMA-treated U937 cells. Also, miRNA pull-down and mass spectrophotometry analysis of PMA-treated U937 cells revealed that miR-24 was specifically associated with alpha-tubulin and hnRNP-E1 proteins. Furthermore, exosomal miR-24 was dramatically reduced when those proteins were inactivated with siRNAs, whereas cellular miR-24 showed no significant effect. We conclude that miR-24 is transported into exosomes from activated macrophages with the support of alpha-tubulin and hnRNP-E1. (C) 2022 Elsevier Inc. All rights reserved. | Choi, Song-Yi; Hong, Su-Hyung; Lee, Heon-Jin | Kyungpook Natl Univ, Sch Dent, Dept Microbiol & Immunol, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Craniofacial Nerve Bone Network Res Ctr, Daegu 41940, South Korea | 57210356632; 8691449100; 36462383000 | heonlee@knu.ac.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 610 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2022 | 3.1 | 46.4 | 0.09 | 2025-06-25 | 1 | 1 | Exosome; Extracellular vesicle; microRNA; Macrophage; Monocyte; U937 | SMALL RNA; BIOMARKERS; STORIES | Exosome; Extracellular vesicle; Macrophage; microRNA; Monocyte; U937 | Exosomes; Heterogeneous-Nuclear Ribonucleoproteins; Humans; MicroRNAs; Monocytes; Tetradecanoylphorbol Acetate; Tubulin; U937 Cells; alpha tubulin; heterogeneous nuclear ribonucleoprotein; microRNA; phorbol 13 acetate 12 myristate; heterogeneous nuclear ribonucleoprotein; microRNA; phorbol 13 acetate 12 myristate; tubulin; Article; cell activation; controlled study; exosome; gene expression; human; human cell; macrophage; mass spectrometry; monocyte; pull-down assay; RNA analysis; RNA sequencing; U-937 cell line; exosome; genetics; metabolism | English | 2022 | 2022-06-25 | 10.1016/j.bbrc.2022.04.048 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Feasibility of Gd-Based prostate cancer targeted magnetic resonance agents using prostate specific membrane antigen | The aim of this work was to evaluate Gd-FC705, a prostate-specific membrane antigen (PSMA)-targeted MRI contrast agent. The r(1) and r(2) relaxivities of Gd-FC705 are 5.94 mM(-1)s(-1) and 17.77 mM(-1)s(-1), respectively, in HSA solution (0.67 mM) at 3 T, which are higher than those of Gd-DOTA. Specific targeting efficacy was found with a 3-fold enhancement between PSMA-negative (PSMA-) and PSMA-positive (PSMA+) cells. The in vivo targeting and bio-distribution of Gd-FC705 were further confirmed using nude mice bearing PC3 human prostate cancer xenografts, which showed a 2-fold increase in the contrast-to-noise ratio (CNR) for PSMAthorn tumors compared to PSMA- tumors 1 h post injection and a longer circulation time than Gd-DOTA. These results demonstrate that Gd-FC705 has great potential as a diagnostic agent for prostate cancer. (C) 2022 Published by Elsevier Inc. | Yang, Ji-ung; Kim, Soyeon; Ahn, Jae Hun; Kim, Min Hwan; Kil, Hee Seup; Chi, Dae Yoon; Lee, Kyo Chul; Lee, Yong Jin; Park, Ji-Ae | Korea Inst Radiol Med Sci KIRAMS, Div Appl RI, Seoul 01812, South Korea; Kyungpook Natl Univ, Dept Med Biol Engn, Daegu 41566, South Korea; Seoul Natl Univ, Grad Sch Translat Med, Coll Med, Seoul 03080, South Korea; FutureChem Co Ltd, Res Inst Labeling, Seoul 04794, South Korea | 57212217968; 57203773250; 57191577991; 59073482400; 15622973300; 59830496500; 42661704100; 56498070500; 16319690600 | jpark@kirams.re.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 607 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2022 | 3.1 | 46.4 | 0 | 2025-06-25 | 0 | 0 | Prostate cancer; Prostate-specific membrane antigen; Human serum albumin; MRI; Contrast agent | CONTRAST AGENTS; THERAPY; PSMA; MRI | Contrast agent; Human serum albumin; MRI; Prostate cancer; Prostate-specific membrane antigen | Animals; Antigens, Surface; Cell Line, Tumor; Feasibility Studies; Glutamate Carboxypeptidase II; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Nude; Prostate; Prostatic Neoplasms; contrast medium; gadolinium; human serum albumin; prostate specific membrane antigen; glutamate carboxypeptidase II; membrane antigen; animal experiment; animal model; Article; cancer diagnosis; contrast to noise ratio; drug distribution; drug efficacy; drug targeting; feasibility study; human; human cell; in vitro study; in vivo study; male; mouse; nonhuman; nuclear magnetic resonance imaging; prostate cancer; animal; diagnostic imaging; nuclear magnetic resonance imaging; nuclear magnetic resonance spectroscopy; nude mouse; pathology; procedures; prostate; prostate tumor; tumor cell line | English | 2022 | 2022-06-04 | 10.1016/j.bbrc.2022.03.136 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Locally transplanted human urine-induced nephron progenitor cells contribute to renal repair in mice kidney with diabetic nephropathy | Chronic Kidney Disease (CKD) is increasingly recognized as a global public health issue. Diabetic ne-phropathy (DN), also known as diabetic kidney disease, is a leading cause of CKD. Regenerative medicine strategy employing nephron progenitor cells (NPCs) is worthy of consideration as an alternative to shortage of donor organs for kidney transplantation. In previous study, we successfully generated induced NPCs (iNPCs) from human urine-derived cells that resembled human embryonic stem cell -derived NPCs. Here, we aimed to investigate the therapeutic potential of iNPCs in DN animal model. The results revealed the therapeutic effect of iNPCs as follows: (1) diminished glomerular hypertrophy, (2) reduced tubulointerstitial fibrosis, (3) low blood urea nitrogen, serum creatinine and albuminuria value, (4) decreased inflammation/fibrosis, (5) enhanced renal regeneration and (6) confirmed safety. This study demonstrates that human iNPCs have a therapeutic potential as a cell source for trans-plantation in patients with kidney diseases. (c) 2022 Published by Elsevier Inc. | Gao, Wei-Wei; Chun, So Young; Kim, Bum Soo; Ha, Yun-Sok; Lee, Jun Nyung; Lee, Eun Hye; Kim, In Yong; You, Seungkwon; Kwon, Tae Gyun | Korea Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 02841, South Korea; STEMLAB Inc, Inst Future Med, Seoul 02841, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu 41405, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu 41940, South Korea; Korea Univ, Coll Life Sciencesand Biotechnol West Bldg, Dept Biotechnol, Anam dong, Seongbuk Gu, Seoul 02841, South Korea; Coll Life Sciencesand Biotechnol, Dept Biotechnol, Seongbuk Gu, Seoul 02841, South Korea | ; Kim, In Yong/GWD-0161-2022; Kim, Soo-Yeon/ADR-9663-2022 | 57371096300; 8688166900; 57202817150; 35487226400; 16301364600; 57189661699; 57193935011; 7201516933; 15073765400 | iykim@korea.ac.kr;bioseung@korea.ac.kr;tgkwon@knu.ac.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 629 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2022 | 3.1 | 46.4 | 0.81 | 2025-06-25 | 7 | 9 | Chronic kidney disease; Diabetic nephropathy; Renal repair; Induced nephron progenitor cells | MESENCHYMAL STEM-CELLS; EPITHELIAL-CELLS; OXIDATIVE STRESS; FIBROBLASTS; THERAPY; DISEASE; INJURY | Chronic kidney disease; Diabetic nephropathy; Induced nephron progenitor cells; Renal repair | Animals; Creatinine; Diabetes Mellitus; Diabetic Nephropathies; Fibrosis; Humans; Kidney; Mice; Nephrons; Renal Insufficiency, Chronic; Stem Cells; creatinine; fibroblast growth factor 9; gamma interferon; protein bcl 2; transcription factor PAX2; tumor necrosis factor; creatinine; albumin urine level; albuminuria; animal cell; animal experiment; animal model; animal tissue; Article; brain cortex; cardiovascular disease; cell differentiation; cell fate; chronic kidney failure; controlled study; creatinine blood level; cryopreservation; diabetic nephropathy; enzyme linked immunosorbent assay; glomerulosclerosis; glucose blood level; histopathology; human embryonic stem cell; immunocytochemistry; immunohistochemistry; inflammation; kidney development; kidney disease; kidney function; kidney hypertrophy; kidney transplantation; kidney tubule cell; male; mesenchymal stem cell; mouse; nephron; nonhuman; oxidative stress; podocyte; public health; real time polymerase chain reaction; regenerative medicine; stem cell; urea nitrogen blood level; urine; urine volume; animal; chronic kidney failure; diabetes mellitus; diabetic nephropathy; fibrosis; human; kidney; nephron; pathology; stem cell | English | 2022 | 2022-11-12 | 10.1016/j.bbrc.2022.09.015 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | NOLC1 knockdown suppresses prostate cancer progressions by reducing AKT phosphorylation and b-catenin accumulation | Although several studies have focused on cancer diagnosis and therapy, prostate cancer (PC) remains an intractable disease. Androgen deprivation therapy (ADT), which is used to treat early stage PC can lead to the development of castration-resistant prostate cancer (CRPC), which is highly associated with androgen receptor (AR) mutations. Nucleolar and coiled-body phosphoprotein 1 (NOLC1) is a chaperone that shuttles between the nucleus and the cytoplasm. Studies suggest that NOLC1 regulates PC pro-gression; however, the underlying mechanisms remain unclear. Herein, we showed that NOLC1 knock-down suppresses PC cell proliferation by altering the signaling pathways and the expression of various proteins involved in DNA replication, amino acid metabolism, and RNA processing. Mechanistically, NOLC1 knockdown suppressed cell cycle progression by inhibiting AKT phosphorylation and b-catenin accumulation. Finally, we showed that NOLC1 expression is higher in human PC than in human hyper -plastic prostate tissues. Altogether, we demonstrated that NOLC1 knockdown suppresses the progression of both AR-positive and AR-negative PC cells by inducing changes in the expression of several genes leading to cell cycle arrest. Thus, NOLC1 might be a novel and promising therapeutic target for PC.(c) 2022 Elsevier Inc. All rights reserved. | Kim, Wansoo; Yeo, Dong-Yeop; Choi, Seong-Kyoon; Kim, Hee-Yeon; Lee, Seoung-Woo; Han, Jee Eun; Ashim, Janbolat; Yu, Wookyung; Jeong, Hyohoon; Park, Jin-Kyu; Park, Song | DGIST, Div Biotechnol, Daegu, South Korea; DGIST, Core Prot Resources Ctr, Daegu, South Korea; DGIST, Dept Brain Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Jeju Natl Univ, Coll Vet Med, Jeju 63243, South Korea | ; Ashim, Janbolat/P-9633-2017 | 57352897900; 57936776800; 55505432500; 58368914700; 57218827581; 57221564355; 57214671240; 56410212300; 17343935400; 35213723500; 57139047900 | jinkyu820@knu.ac.kr;cristaling@dgist.ac.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 635 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2022 | 3.1 | 46.4 | 0.72 | 2025-06-25 | 10 | 8 | Prostate cancer; NOLC1; b-Catenin; AKT; Proteomics | ANDROGEN RECEPTOR; BETA-CATENIN; PATHWAY; PROTEIN; GROWTH; LOCALIZATION; TARGET; P130 | AKT; NOLC1; Prostate cancer; Proteomics; β-Catenin | Androgen Antagonists; beta Catenin; Cell Line, Tumor; Humans; Male; Nuclear Proteins; Phosphoproteins; Phosphorylation; Prostate; Prostatic Neoplasms, Castration-Resistant; Proto-Oncogene Proteins c-akt; Receptors, Androgen; androgen receptor; beta catenin; chaperone; cyclin A1; cyclin B1; cyclin D1; cyclin E; lentivirus vector; mammalian target of rapamycin; natural products and their synthetic derivatives; nucleolar and coiled-body phosphoprotein 1; peptides and proteins; phosphorus; protein kinase B; unclassified drug; androgen receptor; antiandrogen; beta catenin; NOLC1 protein, human; nuclear protein; phosphoprotein; protein kinase B; amino acid metabolism; apoptosis; Article; bioinformatics; cancer diagnosis; cancer growth; carcinogenesis; cell cycle arrest; cell cycle assay; cell cycle progression; cell growth; cell invasion; cell proliferation; chemoluminescence; colony formation; controlled study; DNA methylation; DNA replication; flow cytometry; G2 phase cell cycle checkpoint; gene expression; gene knockdown; gene ontology; gene overexpression; genetic transfection; high performance liquid chromatography; human; human cell; human tissue; immunofluorescence assay; immunoprecipitation; liquid chromatography-mass spectrometry; male; mass spectrometry; microarray analysis; prostate cancer; prostate epithelium cell; prostate tissue; protein expression; protein localization; protein phosphorylation; proteomics; reverse transcription polymerase chain reaction; RNA interference; RNA processing; signal transduction; ultra performance liquid chromatography; upregulation; Western blotting; castration resistant prostate cancer; genetics; metabolism; phosphorylation; prostate; tumor cell line | English | 2022 | 2022-12-20 | 10.1016/j.bbrc.2022.10.038 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Tone Image Classification and Weighted Learning for Visible and NIR Image Fusion | In this paper, to improve the slow processing speed of the rule-based visible and NIR (near-infrared) image synthesis method, we present a fast image fusion method using DenseFuse, one of the CNN (convolutional neural network)-based image synthesis methods. The proposed method applies a raster scan algorithm to secure visible and NIR datasets for effective learning and presents a dataset classification method using luminance and variance. Additionally, in this paper, a method for synthesizing a feature map in a fusion layer is presented and compared with the method for synthesizing a feature map in other fusion layers. The proposed method learns the superior image quality of the rule-based image synthesis method and shows a clear synthesized image with better visibility than other existing learning-based image synthesis methods. Compared with the rule-based image synthesis method used as the target image, the proposed method has an advantage in processing speed by reducing the processing time to three times or more. | Im, Chan-Gi; Son, Dong-Min; Kwon, Hyuk-Ju; Lee, Sung-Hak | Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Deahakro, Daegu 41566, South Korea | ; Son, Dong-Min/LZH-4025-2025 | 57942669400; 57216612214; 55169908300; 7601395661 | shak2@ee.knu.ac.kr; | ENTROPY | ENTROPY-SWITZ | 1099-4300 | 24 | 10 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2022 | 2.7 | 46.5 | 0.66 | 2025-06-25 | 3 | 6 | image fusion; deep learning; supervised learning; infrared image; visible image | TRANSFORM | deep learning; image fusion; infrared image; supervised learning; visible image | English | 2022 | 2022-10 | 10.3390/e24101435 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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