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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | AI Model for Detection of Abdominal Hemorrhage Lesions in Abdominal CT Images | Information technology has been actively utilized in the field of imaging diagnosis using artificial intelligence (AI), which provides benefits to human health. Readings of abdominal hemorrhage lesions using AI can be utilized in situations where lesions cannot be read due to emergencies or the absence of specialists; however, there is a lack of related research due to the difficulty in collecting and acquiring images. In this study, we processed the abdominal computed tomography (CT) database provided by multiple hospitals for utilization in deep learning and detected abdominal hemorrhage lesions in real time using an AI model designed in a cascade structure using deep learning, a subfield of AI. The AI model was used a detection model to detect lesions distributed in various sizes with high accuracy, and a classification model that could screen out images without lesions was placed before the detection model to solve the problem of increasing false positives owing to the input of images without lesions in actual clinical cases. The developed method achieved 93.22% sensitivity and 99.60% specificity. | Park, Young-Jin; Cho, Hui-Sup; Kim, Myoung-Nam | Daegu Gyeongbuk Inst Sci & Technol DGIST, Div Elect & Informat Syst, Daegu 42988, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Engn, Daegu 41566, South Korea | Kim, Sunghoon/Z-2981-2019 | 55753545900; 55321104300; 57212315655 | kimmn@knu.ac.kr;mozart73@dgist.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 10 | 4 | SCIE | ENGINEERING, BIOMEDICAL | 2023 | 3.8 | 35.4 | 0.78 | 2025-06-25 | 6 | 6 | abdominal CT; abdominal hemorrhage; classification; detection lesion; deep learning | abdominal CT; abdominal hemorrhage; classification; deep learning; detection lesion | English | 2023 | 2023-04 | 10.3390/bioengineering10040502 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Biomechanical Effects of Different Sitting Postures and Physiologic Movements on the Lumbar Spine: A Finite Element Study | This study used the finite element method(FEM) to investigate how pressure on the lumbar spine changes during dynamic movements in different postures: standing, erect sitting on a chair, slumped sitting on a chair, and sitting on the floor. Three load modes (flexion, lateral bending, and axial rotation) were applied to the FEM, simulating movements of the lumbar spine. Results showed no significant difference in pressure distribution on the annulus fiber and nucleus pulposus, representing intradiscal pressure, as well as on the cortical bone during movements between standing and erect sitting postures. However, both slumped sitting on a chair and sitting on the floor postures significantly increased pressure on the nucleus pulposus, annulus fibrosus, and cortical bone in all three movements when compared to standing or erect sitting on a chair. Notably, sitting on the floor resulted in even higher pressure on the nucleus pulposus and annulus fibers compared to slumped sitting on a chair. The decreased lumbar lordosis while sitting on the floor led to the highest increase in pressure on the annulus fiber and nucleus pulposus in the lumbar spine. In conclusion, maintaining an erect sitting position with increased lumbar lordosis during seated activities can effectively reduce intradiscal pressure and cortical bone stress associated with degenerative disc diseases and spinal deformities. | Cho, Mingoo; Han, Jun-Sang; Kang, Sungwook; Ahn, Chang-Hwan; Kim, Dong-Hee; Kim, Chul-Hyun; Kim, Kyoung-Tae; Kim, Ae-Ryoung; Hwang, Jong-Moon | Korea Inst Ind Technol, Precis Mech Proc & Control R&D Grp, Jinju Si 52845, South Korea; Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu 41944, South Korea; Gyeongsang Natl Univ, Coll Med, Dept Orthopaed Surg, Jinju Si 52727, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu 41944, South Korea | ; KANG, SUNGWOOK/AAF-6339-2021 | 57556834700; 58288967700; 55611458600; 58076572400; 56648475900; 59603554500; 57201369790; 57196257330; 56367634000 | cmg0142@kitech.re.kr;goodream123@gmail.com;swkang@kitech.re.kr;ach3011@naver.com;dhkim8311@gnu.ac.kr;chgim@knu.ac.kr;nskimkt7@gmail.com;ryoung20@hanmail.net;hti82@hanmail.net; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 10 | 9 | SCIE | ENGINEERING, BIOMEDICAL | 2023 | 3.8 | 35.4 | 0.65 | 2025-06-25 | 5 | 6 | degenerative disc disease; posture; lordosis | degenerative disc disease; lordosis; posture | English | 2023 | 2023-09 | 10.3390/bioengineering10091051 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Current Role of Intra-Articular Injections of Platelet-Rich Plasma in Adhesive Capsulitis of Shoulder: A Systematic Review | Adhesive capsulitis shoulder is a common problem of patients presenting with shoulder pain and disability. The approach to such patients includes a variety of modalities. This systematic review evaluates the efficacy of intra-articular injections of platelet-rich plasma (PRP) in the treatment. A literature search was performed between January 2010 and 30 May 2022. MeSH terms used were 'Platelet-rich plasma' OR 'PRP' AND 'Frozen shoulder' OR 'Adhesive capsulitis shoulder' OR 'Periarthritis shoulder'. The search included published articles in the English language involving human subjects. Studies evaluating other types of shoulder disorders, in vitro studies, review articles, animal-model studies, and pre-clinical trials were excluded. The data regarding study characteristics, efficacy, and safety outcomes were analyzed. A total of 11 studies with 347 patients over 10 years were finally included in this review. Most publications were in 2019 and 2020, mostly from India. This review included seven comparative studies, three case series, and one case report. In seven studies, a single intra-articular PRP injection was administered, whereas in the rest of the studies two or multiple injections were given. Only one study demonstrated an equivocal efficacy of PRP and steroid intra-articular injection. The rest all depicted better clinical and functional outcomes with the PRP injection. Only one study compared the outcomes of hydro-dissection treatment in adhesive capsulitis with the intra-articular PRP injection. The rest all either examined PRP alone or compared it with the steroid intra-articular injection. None of the studies showed any major side effects. The intra-articular injections of PRP in the management of adhesive capsulitis of the shoulder provide a new treatment approach. Further studies are required to ascertain the efficacy and safety of the PRP intraarticular injection as a management alternative in adhesive capsulitis. | Harna, Bushu; Gupta, Vijay; Arya, Shivali; Jeyaraman, Naveen; Rajendran, Ramya Lakshmi; Jeyaraman, Madhan; Gangadaran, Prakash; Khanna, Manish; Hong, Chae Moon; Ahn, Byeong-Cheol | Indian Orthoaped Rheumatol Assoc IORA, Lucknow 226010, Uttar Pradesh, India; Indian Stem Cell Study Grp ISCSG Assoc, Lucknow 226010, Uttar Pradesh, India; Max Super Special Hosp, Dept Orthopaed, New Delhi 110017, India; Elite Clin Orthopaed & Crit Care Ctr, Delhi Gate Agra 282002, Uttar Pradesh, India; Post Grad Inst Med Educ & Res, Dept Radiodiag, Chandigarh 160012, India; Rathimed Special Hosp, Dept Orthopaed, Chennai 600040, Tamil Nadu, India; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Dr MGR Educ & Res Inst, ACS Med Coll & Hosp, Dept Orthopaed, Chennai 600056, Tamil Nadu, India; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea | ; Jeyaraman, Madhan/ABB-8464-2020; Rajendran, Ramya/AAV-6338-2021; Gangadaran, Prakash/AAV-3102-2021 | 57192976510; 58076556900; 57218775221; 57219306833; 57195318729; 57216926503; 54393130400; 57220576074; 37050876700; 7202791511 | madhanjeyaraman@gmail.com;prakashg@knu.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 10 | 1 | SCIE | ENGINEERING, BIOMEDICAL | 2023 | 3.8 | 35.4 | 0.34 | 2025-06-25 | 6 | 6 | periarthritis shoulder; platelet-rich plasma; adhesive capsulitis; frozen shoulder; steroid | adhesive capsulitis; frozen shoulder; periarthritis shoulder; platelet-rich plasma; steroid | English | 2023 | 2023-01 | 10.3390/bioengineering10010021 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Early Osteogenic-Induced Adipose-Derived Stem Cells and Canine Bone Regeneration Potential Analyzed Using Biodegradable Scaffolds | The complex process of bone regeneration is influenced by factors such as inflammatory responses, tissue interactions, and progenitor cells. Currently, multiple traumas can interfere with fracture healing, causing the prolonging or failure of healing. In these cases, bone grafting is the most effective treatment. However, there are several drawbacks, such as morbidity at the donor site and availability of suitable materials. Advantages have been provided in this field by a variety of stem cell types. Adipose-derived stem cells (ASCs) show promise. In the radiological examination of this study, it was confirmed that the C/S group showed faster regeneration than the other groups, and Micro-CT also showed that the degree of bone formation in the defect area was highest in the C/S group. Compared to the control group, the change in cortical bone area in the defect area decreased in the sham group (0.874), while it slightly increased in the C/S group (1.027). An increase in relative vascularity indicates a decrease in overall bone density, but a weak depression filled with fibrous tissue was observed outside the compact bone. It was confirmed that newly formed cortical bone showed a slight difference in bone density compared to surrounding normal bone tissue due to increased distribution of cortical bone. In this study, we investigated the effect of bone regeneration by ADMSCs measured by radiation and pathological effects. These data can ultimately be applied to humans with important clinical applications in various bone diseases, regenerative, and early stages of formative differentiation. | Yun, Hyun-Ho; Kim, Seong-Gon; Park, Se-Il; Jo, Woori; Kang, Kyung-Ku; Lee, Eun-Joo; Kim, Dong-Kyu; Jung, Hoe-Su; Son, Ji-Yoon; Park, Jae-Min; Park, Hyun-Sook; Lee, Sunray; Shin, Hong-In; Hong, Il-Hwa; Jeong, Kyu-Shik | Kyungpook Natl Univ, Dept Vet Pathol, Coll Vet Med, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Preclin Res Ctr, Daegu 41061, South Korea; Yonsei Univ, Coll Med, Cardiovasc Prod Evaluat Ctr, Seoul 03722, South Korea; Cell Engn Origin Res Ctr, Seoul 03150, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Pathol & Regenerat Med, Daegu 41940, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Dept Vet Pathol, Jinju 52828, South Korea; Hoseo Univ, Inst Next Generat Unified Technol, Asan 31499, South Korea | ; Kim, Dong/AEG-4375-2022; park, seil/KLD-0847-2024; Kim, Sung-Soo/ABD-3771-2021 | 57211248080; 55718780800; 35076447300; 55848825000; 57215079376; 58363110000; 57779034700; 58728242200; 57211247483; 57221334299; 57198844113; 41861684400; 24377179200; 8702273100; 7201556460 | hyun6551@kmedihub.re.kr;sgkim@kmedihub.re.kr;seil-park@hanmail.ne;c2dar@kmedihub.re.kr;qzpmqzpm@naver.com;miffy525@hanmail.net;dgkim728@kmedihub.re.kr;unghs2000@kmedihub.re.kr;iyoon1095@naver.com;kow612@naver.com;hsparkkwon@hotmail.com;sunray@cefobio.com;hishin@knu.ac.kr;ihhong@gnu.ac.kr;jeongks@knu.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 10 | 11 | SCIE | ENGINEERING, BIOMEDICAL | 2023 | 3.8 | 35.4 | 0.26 | 2025-06-25 | 2 | 2 | canine adipose-derived mesenchymal stem cells; adipose-derived stem cells; osteodifferentiation | adipose-derived stem cells; canine adipose-derived mesenchymal stem cells; osteodifferentiation | English | 2023 | 2023-11 | 10.3390/bioengineering10111311 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effect of Electrocautery and Laser Treatment on the Composition and Morphology of Surface-Modified Titanium Implants | The purpose of this study was to investigate the effects of different peri-implantitis treatment methods (Er,Cr:YSGG laser, diode laser, and electrocautery) on various titanium implant surfaces: machined; sandblasted, large-grit, and acid-etched; and femtosecond laser-treated surfaces. Grade 4 titanium (Ti) disks, with a diameter of 10 mm and a thickness of 1 mm, were fabricated and treated using the aforementioned techniques. Subsequently, each treated group of disks underwent different peri-implantitis treatment methods: Er,Cr:YSGG laser (Biolase, Inc., Foothill Ranch, CA, USA), diode laser (Biolase, Inc., Foothill Ranch, CA, USA), and electrocautery (Ellman, Hicksville, NY, USA). Scanning electron microscopy, energy-dispersive X-ray spectroscopy, and wettability were used to characterize the chemical compositions and surfaces of the treated titanium surfaces. Significant changes in surface roughness were observed in both the electrocautery (Sa value of machined surface = 0.469, SLA surface = 1.569, femtosecond laser surface = 1.741, and p = 0.025) and Er,Cr:YSGG laser (Ra value of machined surface = 1.034, SLA surface = 1.380, femtosecond laser surface = 1.437, and p = 0.025) groups. On femtosecond laser-treated titanium implant surfaces, all three treatment methods significantly reduced the surface contact angle (control = 82.2 degrees, diode laser = 74.3 degrees, Er,Cr:YSGG laser = 73.8 degrees, electrocautery = 76.2 degrees, and p = 0.039). Overall, Er,Cr:YSGG laser and electrocautery treatments significantly altered the surface roughness of titanium implant surfaces. As a result of surface composition after different peri-implantitis treatment methods, relative to the diode laser and electrocautery, the Er,Cr:YSGG laser increased oxygen concentration. The most dramatic change was observed after Er:Cr;YSGG laser treatment, urging caution for clinical applications. Changes in surface composition and wettability were observed but were not statistically significant. Further research is needed to understand the biological implications of these peri-implantitis treatment methods. | Lee, Jin-Seok; Son, Keunbada; Hwang, Sung-Min; Son, Young-Tak; Kim, Yong-Gun; Suh, Jo-Young; Hwang, Jun Ho; Kwon, Sung-Min; Lee, Jong Hoon; Kim, Hyun Deok; Lee, Kyu-Bok; Lee, Jae-Mok | Kyungpook Natl Univ, Sch Dent, Dept Periodontol, Daegu 41940, South Korea; Kyungpook Natl Univ, Adv Dent Device Dev Inst A3DI, Daegu 41940, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, Daegu 41940, South Korea; Kyungpook Natl Univ, Inst Adv Convergence Technol, Daegu 41061, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu 41940, South Korea | Son, Keunbada/AAG-8089-2019; SON, Keunbada/AAG-8089-2019; Kim, Yong Joon/IQS-7291-2023; Lee, Jin-Seok/J-5608-2012 | 58727981800; 57202916520; 57870525500; 57219111205; 55622694400; 7201514992; 57204783286; 56949626400; 57204786073; 55663858300; 15925571200; 17346330000 | jin5586@gmail.com;oceanson@knu.ac.kr;lhwangl89@naver.com;dudxkr741@naver.com;periokyg@knu.ac.kr;jysuh@knu.ac.kr;hjh@iact.or.kr;sungmin@iact.or.kr;laser@knu.ac.kr;hdkim@knu.ac.kr;kblee@knu.ac.kr;leejm@knu.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 10 | 11 | SCIE | ENGINEERING, BIOMEDICAL | 2023 | 3.8 | 35.4 | 0.52 | 2025-06-25 | 5 | 4 | dental implant; electrocautery treatment; laser treatment; surface roughness | dental implant; electrocautery treatment; laser treatment; surface roughness | English | 2023 | 2023-11 | 10.3390/bioengineering10111251 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effects of Alterations in Resting-State Neural Networks on the Severity of Neuropathic Pain after Spinal Cord Injury | Neuropathic pain (NP) following spinal cord injury (SCI) is refractory to pain control strategies, and the underlying neuronal mechanisms remain poorly understood. This study aimed to determine the brain regions engaged in maintaining a spontaneous resting state and the link between those regions and the severity of NP in patients with incomplete SCI. Seventy-three subjects (41 patients and 32 age- and sex-matched healthy controls) participated in this retrospective study. Regarding the neurological level of injury, patients with incomplete SCI experienced at-level or below-level NP. The severity of NP was evaluated using a visual analog scale (VAS), and patients were divided into mild and moderate-severe NP groups based on VAS scores. Graph theory and fractional amplitude of low-frequency fluctuation (fALFF) analyses were performed to compare resting-state functional magnetic resonance imaging (fMRI) analysis results among the three groups. Graph theory analysis was performed through a region of interest (ROI)-to-ROI analysis and then fALFF analysis was performed in the brain regions demonstrating significant differences among the three groups analyzed using the graph theory. We evaluated whether the brain regions showing significant differences using graph theory and fALFF correlated with the VAS scores. Patients with moderate-severe NP showed reduced node degree and fALFF in the left middle frontal gyrus compared with those with mild NP and healthy controls. Furthermore, patients with severe NP demonstrated increased average path lengths and reduced fALFF values in the posterior cingulate gyrus. This study found that changes in intrinsic oscillations of fMRI signals in the middle frontal gyrus and posterior cingulate gyrus were significant considering the severity of NP. | Park, Eunhee; Park, Jang Woo; Kim, Eunji; Min, Yu-Sun; Lee, Hui Joong; Jung, Tae-Du; Chang, Yongmin | Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Rehabil Med, Chilgok Hosp, Daegu 41404, South Korea; Korea Inst Radiol & Med Sci, Korea Radioisotope Ctr Pharmaceut, Seoul 01812, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu 41944, South Korea | 56107216400; 57202928230; 57215273419; 48061349800; 23485776600; 36622364500; 7501840633 | ehmdpark@knu.ac.kr;giantstar.jw@gmail.com;geekimeun@gmail.com;ssuni119@naver.com;leehuijoong@knu.ac.kr;teeed0522@knu.ac.kr;ychang@knu.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 10 | 7 | SCIE | ENGINEERING, BIOMEDICAL | 2023 | 3.8 | 35.4 | 0.26 | 2025-06-25 | 2 | 2 | neuropathic pain; resting-state fMRI; spinal cord injury | neuropathic pain; resting-state fMRI; spinal cord injury | English | 2023 | 2023-07 | 10.3390/bioengineering10070860 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Estimating the impact of environmental management on strawberry yield using publicly available agricultural data in South Korea | Advanced information and communication technologies (ICTs) have made data collection more efficient for agricultural studies. Using publicly available database in South Korea, we estimated the relationship between the management of air temperature and relative humidity and the strawberry yield during two harvest seasons. Longitudinal data of multiple greenhouses were merged and processed, and mixed-effects models were applied to account both observed and unobserved factors across the greenhouses. The averages of air temperature and relative humidity inside each greenhouse do not take volatility of the time-varying variables into consideration, so we assessed the management of each greenhouse by the percent of time that air temperature between 15 degrees C and 20 degrees C (denoted as T%) and the percent of time that relative humidity between 0% and 50% (denoted by H%). The statistical models estimated that the strawberry yield decreases with respect to the number of days since harvest began and the rate of decrease is slower when T% and H% are higher. This study used large-scale multilocation data to provide the practical suggestion that air temperature and relative humidity should be maintained within the optimal ranges to mitigate the loss of strawberry yield especially at the later phase of a harvest season. | Kim, Steven; Jo, Jung Su; Luk, Vicky; Kim, Sung Kyeom; Kim, Dong Sub | Calif State Univ, Math & Stat, Seaside, CA USA; Kyungpook Natl Univ, Hort Sci, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea; Calif State Univ, Appl Environm Sci, Seaside, CA USA; Kongju Natl Univ, Hort, Yesan, South Korea | Kim, Sung Kyeom/AAD-9230-2019 | 55243558900; 57197337268; 57874138000; 50262290200; 15760138600 | skkim76@knu.ac.kr;dongsub@kongju.ac.kr; | PEERJ | PEERJ | 2167-8359 | 11 | SCIE | MULTIDISCIPLINARY SCIENCES | 2023 | 2.3 | 35.4 | 0.17 | 2025-06-25 | 1 | 1 | Relative humidity; Air temperature; Open API; Mixed-effects model | FRUIT-SET; TOMATO PLANTS; LEAF WEIGHT; GROWTH; TEMPERATURE; HUMIDITY; GREENHOUSE; QUALITY; POLLEN; AREA | Air temperature; Mixed-effects model; Open API; Relative humidity | air temperature; article; environmental management; greenhouse; nonhuman; relative humidity; season; South Korea; strawberry | English | 2023 | 2023-05-11 | 10.7717/peerj.15390 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Evolution and Clinical Advances of Platelet-Rich Fibrin in Musculoskeletal Regeneration | Over the past few decades, various forms of platelet concentrates have evolved with significant clinical utility. The newer generation products, including leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF), have shown superior biological properties in musculoskeletal regeneration than the first-generation concentrates, such as platelet-rich plasma (PRP) and plasma rich in growth factors. These newer platelet concentrates have a complete matrix of physiological fibrin that acts as a scaffold with a three-dimensional (3D) architecture. Further, it facilitates intercellular signaling and migration, thereby promoting angiogenic, chondrogenic, and osteogenic activities. A-PRF with higher leukocyte inclusion possesses antimicrobial activity than the first generations. Due to the presence of enormous amounts of growth factors and anti-inflammatory cytokines that are released, A-PRF has the potential to replicate the various physiological and immunological factors of wound healing. In addition, there are more neutrophils, monocytes, and macrophages, all of which secrete essential chemotactic molecules. As a result, both L-PRF and A-PRF are used in the management of musculoskeletal conditions, such as chondral injuries, tendinopathies, tissue regeneration, and other sports-related injuries. In addition to this, its applications have been expanded to include the fields of reconstructive cosmetic surgery, wound healing in diabetic patients, and maxillofacial surgeries. | Narayanaswamy, Ragunanthan; Patro, Bishnu Prasad; Jeyaraman, Naveen; Gangadaran, Prakash; Rajendran, Ramya Lakshmi; Nallakumarasamy, Arulkumar; Jeyaraman, Madhan; Ramani, Prasanna; Ahn, Byeong-Cheol | Rathimed Special Hosp, Dept Orthopaed, Chennai 600040, India; All India Inst Med Sci, Dept Orthopaed, Bhubaneswar 751019, India; Indian Stem Cell Study Grp ISCSG Assoc, Lucknow 226010, India; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea; ACS Med Coll & Hosp, Dr MGR Educ & Res Inst, Dept Orthopaed, Chennai 600056, India; Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, India; Amrita Vishwa Vidyapeetham, Amrita Sch Phys Sci, Dept Sci, Dhanvanthri Lab, Coimbatore 641112, India; Amrita Vishwa Vidyapeetham, Ctr Excellence Adv Mat & Green Technol CoE AMGT, Amrita Sch Engn, Coimbatore 641112, India | ; Ramani, Prasanna/ABZ-7862-2022; Rajendran, Ramya/AAV-6338-2021; Jeyaraman, Madhan/ABB-8464-2020; Gangadaran, Prakash/AAV-3102-2021 | 57857662300; 57207798394; 57219306833; 54393130400; 57195318729; 57434698100; 57216926503; 55761773500; 7202791511 | arulmmcian@gmail.com;madhanjeyaraman@gmail.com; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 10 | 1 | SCIE | ENGINEERING, BIOMEDICAL | 2023 | 3.8 | 35.4 | 2.11 | 2025-06-25 | 34 | 37 | platelet-rich fibrin; cytokines; intercellular signaling; growth factors | cytokines; growth factors; intercellular signaling; platelet-rich fibrin | English | 2023 | 2023-01 | 10.3390/bioengineering10010058 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Method for Solving Difficulties in Rhythm Classification Caused by Few Samples and Similar Characteristics in Electrocardiograms | A method for accurately analyzing electrocardiograms (ECGs), which are obtained from electrical signals generated by cardiac activity, is essential in heart disease diagnosis. However, rhythms are typically obtained with relatively few data samples and similar characteristics, making them difficult to classify. To solve these issues, we proposed a novel method that distinguishes a given ECG rhythm using a beat score map (BSM) image. Through the proposed method, the associations between beats and previously used features, such as the R-R interval, were considered. Rhythm classification was implemented by training a convolutional neural network model and using transfer learning with the created BSM image. As a result, the proposed method for ECG rhythms with small data samples showed significant results. It also showed good performance in differentiating atrial fibrillation (AFIB) and atrial flutter (AFL) rhythms, which are difficult to distinguish due to their similar characteristics. The performance for rhythms with a small number of samples of the proposed method is 20% better than an existing method. In addition, the performance based on the F-1 score for classifying AFIB and AFL of the proposed method is 30% better than the existing method. This study solved the previous limitations caused by small sample numbers and similar rhythms. | Lee, Jaewon; Shin, Miyoung | Kyungpook Natl Univ, Sch Elect & Elect Engn, Biointelligence & Data Min Lab, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 58377059800; 7401536642 | shinmy@knu.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 10 | 2 | SCIE | ENGINEERING, BIOMEDICAL | 2023 | 3.8 | 35.4 | 0.91 | 2025-06-25 | 4 | 7 | ECG rhythms; rhythm classification; deep learning; convolutional neural network (CNN) | convolutional neural network (CNN); deep learning; ECG rhythms; rhythm classification | English | 2023 | 2023-02 | 10.3390/bioengineering10020196 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Multivariate CNN Model for Human Locomotion Activity Recognition with a Wearable Exoskeleton Robot | This study introduces a novel convolutional neural network (CNN) architecture, encompassing both single and multi-head designs, developed to identify a user's locomotion activity while using a wearable lower limb robot. Our research involved 500 healthy adult participants in an activities of daily living (ADL) space, conducted from 1 September to 30 November 2022. We collected prospective data to identify five locomotion activities (level ground walking, stair ascent/descent, and ramp ascent/descent) across three terrains: flat ground, staircase, and ramp. To evaluate the predictive capabilities of the proposed CNN architectures, we compared its performance with three other models: one CNN and two hybrid models (CNN-LSTM and LSTM-CNN). Experiments were conducted using multivariate signals of various types obtained from electromyograms (EMGs) and the wearable robot. Our results reveal that the deeper CNN architecture significantly surpasses the performance of the three competing models. The proposed model, leveraging encoder data such as hip angles and velocities, along with postural signals such as roll, pitch, and yaw from the wearable lower limb robot, achieved superior performance with an inference speed of 1.14 s. Specifically, the F-measure performance of the proposed model reached 96.17%, compared to 90.68% for DDLMI, 94.41% for DeepConvLSTM, and 95.57% for LSTM-CNN, respectively. | Son, Chang-Sik; Kang, Won-Seok | Daegu Gyeongbuk Inst Sci & Technol DGIST, Div Intelligent Robot, Daegu 42988, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu 41944, South Korea | ; Son, Chang-Sik/AAQ-3214-2021; Kang, Won-Seok/Q-4994-2018 | 56438989900; 35332405500 | wskang@dgist.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 10 | 9 | SCIE | ENGINEERING, BIOMEDICAL | 2023 | 3.8 | 35.4 | 0.39 | 2025-06-25 | 2 | 4 | human activity recognition; wearable robot; single-head CNN; multi-head CNN; hyperparameter optimization; time series classification | human activity recognition; hyperparameter optimization; multi-head CNN; single-head CNN; time series classification; wearable robot | English | 2023 | 2023-09 | 10.3390/bioengineering10091082 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Speech Perception Improvement Algorithm Based on a Dual-Path Long Short-Term Memory Network | Current deep learning-based speech enhancement methods focus on enhancing the time-frequency representation of the signal. However, conventional methods can lead to speech damage due to resolution mismatch problems that emphasize only specific information in the time or frequency domain. To address these challenges, this paper introduces a speech enhancement model designed with a dual-path structure that identifies key speech characteristics in both the time and time-frequency domains. Specifically, the time path aims to model semantic features hidden in the waveform, while the time-frequency path attempts to compensate for the spectral details via a spectral extension block. These two paths enhance temporal and spectral features via mask functions modeled as LSTM, respectively, offering a comprehensive approach to speech enhancement. Experimental results show that the proposed dual-path LSTM network consistently outperforms conventional single-domain speech enhancement methods in terms of speech quality and intelligibility. | Koh, Hyeong Il; Na, Sungdae; Kim, Myoung Nam; Ieracitano, Cosimo; Zhang, Xuejun | Kyungpook Natl Univ, Grad Sch, Dept Med & Biol Engn, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Biomed Engn, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Engn, Daegu 41944, South Korea | Kim, Sunghoon/Z-2981-2019; Ieracitano, Cosimo/AAB-9583-2019 | 58728754000; 56366244500; 57212315655 | bluepoison14@knu.ac.kr;kimmn@knu.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 10 | 11 | SCIE | ENGINEERING, BIOMEDICAL | 2023 | 3.8 | 35.4 | 0.39 | 2025-06-25 | 1 | 3 | speech enhancement; STFT; LSTM; encoder-decoder structure; dual-path network; spectral extension block; mel-filter banks; merge algorithm | dual-path network; encoder–decoder structure; LSTM; mel-filter banks; merge algorithm; spectral extension block; speech enhancement; STFT | English | 2023 | 2023-11 | 10.3390/bioengineering10111325 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Depression of Synaptic N-methyl-D-Aspartate Responses by Xenon and Nitrous Oxide | In "synapse bouton preparation" of rat hippocampal CA3 neurons, we examined how Xe and N2O modulate N-methyl-D-aspartate (NMDA) receptor-mediated spontaneous and evoked excitatory post-synaptic currents (sEPSC(NMDA) and eEPSC(NMDA)). This preparation is a mechanically isolated single neuron attached with nerve endings (boutons) preserving normal physiologic function and promoting the exact evaluation of sEPSC(NMDA) and eEPSC(NMDA) responses without influence of extrasynaptic, glial, and other neuronal tonic currents. These sEPSCs and eEPSCs are elicited by spontaneous glutamate release from many homologous glutamatergic boutons and by focal paired-pulse electric stimulation of a single bouton, respectively. The s/eEPSC(AMPA/KA) and s/eEPSC(NMDA) were isolated pharmacologically by their specific antagonists. Thus, independent contributions of pre- and postsynaptic responses could also be quantified. All kinetic properties of s/eEPSC(AMPA/KA) and s/eEPSC(NMDA) were detected clearly. The s/eEPSC(NMDA) showed smaller amplitude and slower rise and 1/e decay time constant (tau(Decay)) than s/eEPSC(AMPA/KA). Xe (70%) and N2O (70%) significantly decreased the frequency and amplitude without altering the tau(Decay) of sEPSC(NMDA). They also decreased the amplitude but increased the Rf and PPR without altering the tau(Decay) of the eEPSC(NMDA). These data show clearly that "synapse bouton preparation" can be an accurate model for evaluating s/eEPSC(NMDA). Such inhibitory effects of gas anesthetics are primarily due to presynaptic mechanisms. Present results may explain partially the powerful analgesic effects of Xe and N2O. | Kotani, Naoki; Jang, Il-Sung; Nakamura, Michiko; Nonaka, Kiku; Nagami, Hideaki; Akaike, Norio | Kitamoto Hosp, Saitama, Japan; Kyungpook Natl Univ, Daegu, South Korea; Kumamoto Hlth Sci Univ, Kumamoto, Japan; Kumamoto Kinoh Hosp, Kumamoto, Japan | 56708285400; 7102177910; 36051866000; 9436836200; 57083820600; 57194502749 | akaike.sachin715@juryo.or.jp; | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | J PHARMACOL EXP THER | 0022-3565 | 1521-0103 | 384 | 1 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 3.1 | 35.5 | 0.97 | 2025-06-25 | 6 | 6 | ACID RECEPTOR ANTAGONISTS; NMDA RECEPTOR; DEVELOPMENTAL REGULATION; PRESYNAPTIC BOUTONS; TRANSMISSION; GLUTAMATE; CURRENTS; PAIN; NEURONS; NEUROTRANSMISSION | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; N-Methylaspartate; Nitrous Oxide; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Xenon; AMPA receptor; glutamic acid; kainic acid receptor; n methyl dextro aspartic acid receptor; nitrous oxide; xenon; alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid; n methyl dextro aspartic acid receptor; n methylaspartic acid; xenon; analgesic activity; animal experiment; animal model; animal tissue; Article; cell function; controlled study; current amplitude; decay time constant; drug effect; electrostimulation; evoked response; excitatory postsynaptic potential; female; frequency; glia cell; hippocampal CA3 region; male; mouse; nerve ending; nonhuman; protein function; synaptic membrane; animal; rat; synaptic transmission; Wistar rat | English | 2023 | 2023-01-01 | 10.1124/jpet.122.001346 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Protein Kinase A Is Responsible for the Presynaptic Inhibition of Glycinergic and Glutamatergic Transmissions by Xenon in Rat Spinal Cord and Hippocampal CA3 Neurons | The effects of a general anesthetic xenon (Xe) on spontaneous, miniature, electrically evoked synaptic transmissions were ex-amined using the "synapse bouton preparation," with which we can clearly evaluate pure synaptic responses and accurately quantify pre-and postsynaptic transmissions. Glycinergic and glutamatergic transmissions were investigated in rat spinal sa-cral dorsal commissural nucleus and hippocampal CA3 neu-rons, respectively. Xe presynaptically inhibited spontaneous glycinergic transmission, the effect of which was resistant to te-trodotoxin, Cd2+, extracellular Ca2+, thapsigargin (a selective sarcoplasmic/endoplasmic reticulum Ca2+-ATPase inhibitor), SQ22536 (an adenylate cyclase inhibitor), 8-Br-cAMP (mem-brane-permeable cAMP analog), ZD7288 (an hyperpolarization-activated cyclic nucleotide-gated channel blocker), chelerythr-ine (a PKC inhibitor), and KN-93 (a CaMKII inhibitor) while being sensitive to PKA inhibitors (H-89, KT5720, and Rp-cAMPS). Moreover, Xe inhibited evoked glycinergic transmission, which was canceled by KT5720. Like glycinergic transmission, spon-taneous and evoked glutamatergic transmissions were also inhibited by Xe in a KT5720-sensitive manner. Our results sug-gest that Xe decreases glycinergic and glutamatergic sponta-neous and evoked transmissions at the presynaptic level in a PKA-dependent manner. These presynaptic responses are in-dependent of Ca2+ dynamics. We conclude that PKA can be the main molecular target of Xe in the inhibitory effects on both inhibitory and excitatory neurotransmitter release. | Jang, Il-Sung; Nakamura, Michiko; Nonaka, Kiku; Noda, Mami; Kotani, Naoki; Katsurabayashi, Shutaro; Nagami, Hideaki; Akaike, Norio | Kyungpook Natl Univ, Daegu, South Korea; Kumamoto Hlth Sci Univ, Kumamoto, Japan; Kyushu Univ, Fukuoka, Japan; Kitamoto Hosp, Saitama, Japan; Fukuoka Univ, Fukuoka, Japan; Kumamoto Kinoh Hosp, Kumamoto, Japan; Kumamoto Kinoh Hosp, Medical Corp, Res Div Clin Pharmacol, Juryou Grp, 6-8-1 Yamamuro, Kumamoto 8608518, Japan | Noda, Mami/AAC-3949-2020; Kotani, Naoki/HSC-6226-2023 | 7102177910; 36051866000; 9436836200; 7402801567; 56708285400; 6602989100; 57083820600; 57194502749 | akaike.sachin715@juryo.or.jp; | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | J PHARMACOL EXP THER | 0022-3565 | 1521-0103 | 386 | 3 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 3.1 | 35.5 | 0.32 | 2025-06-25 | 3 | 2 | METHYL-D-ASPARTATE; SYNAPTIC-TRANSMISSION; TRANSMITTER RELEASE; INTRATERMINAL CA2+; NITROUS-OXIDE; II INHIBITOR; CALCIUM-IONS; CURRENTS; KN-93; TETRODOTOXIN | Animals; Cyclic AMP-Dependent Protein Kinases; Hippocampus; Neurons; Neurotransmitter Agents; Presynaptic Terminals; Rats; Rats, Wistar; Spinal Cord; Synaptic Transmission; Xenon; calcium calmodulin dependent protein kinase II; calcium ion; cyclic AMP; cyclic AMP dependent protein kinase; protein kinase C; xenon; agents interacting with transmitter, hormone or drug receptors; cyclic AMP dependent protein kinase; xenon; action potential; animal cell; Article; calcium transport; CaMKII signaling pathway; cell isolation; cell stimulation; controlled study; electrophysiological procedures; evoked response; glutamatergic transmission; glycinergic transmission; hippocampal CA3 region; molecular dynamics; nerve cell; neurotransmission; neurotransmitter release; nonhuman; presynaptic inhibition; presynaptic potential; rat; signal transduction; spinal cord; animal; hippocampus; metabolism; nerve cell; nerve ending; spinal cord; synaptic transmission; Wistar rat | English | 2023 | 2023-09-01 | 10.1124/jpet.123.001599 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Retraction | RETRACTION: Inhibition of NF-κB signaling and HSP70/HSP90 proteins by newly synthesized hydrazide derivatives in arthritis model (Retraction of Vol 394, Pg 1497, 2021) | Khan, Ashraf Ullah; Khan, Amna; Khan, Adnan; Shal, Bushra; Aziz, Abdul; Ahmed, Muhammad Naeem; Islam, Salman Ul; Ali, Hussain; Shehzad, Adeeb; Khan, Salman | Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Pharmacol Sci Res Lab, Islamabad, Pakistan; Univ Azad Jammu & Kashmir, Dept Chem, Muzaffarabad 13100, Pakistan; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu, South Korea; Natl Univ Sci & Technol NUST, Sch Mech & Mfg Engn SMME, Dept Biomed Engn & Sci, Islamabad, Pakistan | Ahmed, Muhammad/ABH-6137-2020; Khan, Salman/AAR-7269-2021; Shehzad, Adeeb/HHN-4847-2022; khan, shahan/M-6985-2017 | 57200756218; 57209213282; 57205082415; 57202263896; 59044921400; 15845156500; 56985186700; 56003879200; 36162526700; 58961283100 | skhan@qau.edu.pk; | NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | N-S ARCH PHARMACOL | 0028-1298 | 1432-1912 | 396 | 11 | SCIE | PHARMACOLOGY & PHARMACY | 2023 | 3.1 | 35.5 | 3.77 | 2025-06-25 | 1 | 1 | retraction notice | English | 2023 | 2023-11 | 10.1007/s00210-023-02727-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | Meeting Abstract | Busulfan plus melphalan versus high-dose melphalan as a conditioning regimen for autologous stem cell transplantation in multiple myeloma with high-risk features (KMM 2015) | Jung, Sung-Hoon; Lee, Je-Jung; Kim, Mihee; Min, Chang-Ki; Lee, Ji Yun; Jo, Jae-Cheol; Yoon, Sung-Soo; Lim, Sung-Nam; Do, Young Rok; Kim, Kihyun; Lee, Jae Hoon; Yoo, Kwai Han; Bae, Sung Hwa; Yi, Jun Ho; Jung, Jongheon; Eom, Hyeon-Seok | Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Sch Med, Hwasun, South Korea; Kyungpook Natl Univ, Dept Hematol Oncol, Sch Med, Kyungpook Natl Univ Hosp, Daegu, South Korea; Chonnam Natl Univ, Hwasun Hosp, Hwasun, South Korea; Seoul St Marys Hosp, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Seoul, South Korea; Ulsan Univ Hosp, Ulsan, South Korea; Seoul Natl Univ, Coll Med, Seoul, South Korea; Inje Univ, Coll Med, Haeundae Paik Hosp, Busan, South Korea; Keimyung Univ, Dept Hematooncol, Dongsan Med Ctr, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Seoul, South Korea; Gachon Univ, Gil Med Ctr, Seongnam, South Korea; Daegu Catholic Univ Hosp, Daegu, South Korea; Chung Ang Univ Hosp, Seoul, South Korea; Natl Canc Ctr, Goyang, South Korea; Natl Canc Ctr Korea, Dept Internal Med, Goyang, South Korea | Kim, Kihyun/D-5175-2013; Jo, Jae-Cheol/CAE-9453-2022; Hyun-Jung, Kim/E-8074-2011; KIM, JIN/I-6927-2019; Lee, Jung-Hye/F-6974-2013; Yi, Jun Ho/GXZ-8144-2022 | CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | CL LYMPH MYELOM LEUK | 2152-2650 | 2152-2669 | 23 | SCIE | HEMATOLOGY;ONCOLOGY | 2023 | 2.7 | 35.6 | 0 | English | 2023 | 2023-09 | 바로가기 | 바로가기 |
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