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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article The role of Zur-regulated lipoprotein A in bacterial morphology, antimicrobial susceptibility, and production of outer membrane vesicles in Acinetobacter baumannii Background Zinc uptake-regulator (Zur)-regulated lipoprotein A (ZrlA) plays a role in bacterial fitness and overcoming antimicrobial exposure in Acinetobacter baumannii. This study further characterized the zrlA gene and its encoded protein and investigated the roles of the zrlA gene in bacterial morphology, antimicrobial susceptibility, and production of outer membrane vesicles (OMVs) in A. baumannii ATCC 17978. Results In silico and polymerase chain reaction analyses showed that the zrlA gene was conserved among A. baumannii strains with 97-100% sequence homology. Recombinant ZrlA protein exhibited a specific enzymatic activity of D-alanine-D-alanine carboxypeptidase. Wild-type A. baumannii exhibited more morphological heterogeneity than a Delta zrlA mutant strain during stationary phase. The Delta zrlA mutant strain was more susceptible to gentamicin than the wild-type strain. Sizes and protein profiles of OMVs were similar between the wild-type and Delta zrlA mutant strains, but the Delta zrlA mutant strain produced 9.7 times more OMV particles than the wild-type strain. OMVs from the Delta zrlA mutant were more cytotoxic in cultured epithelial cells than OMVs from the wild-type strain. Conclusions The present study demonstrated that A. baumannii ZrlA contributes to bacterial morphogenesis and antimicrobial resistance, but its deletion increases OMV production and OMV-mediated host cell cytotoxicity. Kim, Nayeong; Kim, Hyo Jeong; Oh, Man Hwan; Kim, Se Yeon; Kim, Mi Hyun; Son, Joo Hee; Kim, Seung Il; Shin, Minsang; Lee, Yoo Chul; Lee, Je Chul Kyungpook Natl Univ, Sch Med, Dept Microbiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Dankook Univ, Dept Nanobiomed Sci, Cheonan, South Korea; Korea Basic Sci Inst, Drug & Dis Target Team, Ochang, South Korea; Univ Sci & Technol UST, Dept Bioanalyt Sci, Daejeon, South Korea ; Kim, Hyo Yeol/HLP-5150-2023; Kim, Tae/B-9921-2013; Lee, JongGu/B-7384-2013 57211500281; 57221772924; 57113010400; 57209346647; 57203466774; 57201721443; 57206876176; 7401536650; 8710443700; 25930392000 leejc@knu.ac.kr; BMC MICROBIOLOGY BMC MICROBIOL 1471-2180 21 1 SCIE MICROBIOLOGY 2021 4.465 43.4 0.72 2025-07-30 11 12 Acinetobacter baumannii; Zur-regulated gene; ZrlA; Carboxypeptidase; Outer membrane vesicle Acinetobacter baumannii; Carboxypeptidase; Outer membrane vesicle; ZrlA; Zur-regulated gene A549 Cells; Acinetobacter baumannii; Anti-Bacterial Agents; Bacterial Proteins; Computational Biology; Computer Simulation; Drug Resistance, Bacterial; Extracellular Vesicles; Gentamicins; Humans; Lipoprotein(a); Mutation; Zinc; carboxypeptidase transpeptidase; gentamicin; lipoprotein A; unclassified drug; Zur regulated lipoprotein A; antiinfective agent; bacterial protein; gentamicin; lipoprotein A; zinc; Acinetobacter baumannii; antibiotic sensitivity; Article; bacterial gene; bacterial growth; bacterial strain; cell culture; cell size; chromatography by stationary phase; computer model; controlled study; cytotoxicity; enzyme activity; epithelium cell; gene deletion; gene function; gene sequence; genetic analysis; genetic heterogeneity; human; human cell; membrane vesicle; microbial morphology; morphogenesis; mutant; nonhuman; outer membrane vesicle; polymerase chain reaction; protein function; sequence analysis; sequence homology; wild type; zrlA gene; A-549 cell line; Acinetobacter baumannii; antibiotic resistance; biology; computer simulation; drug effect; exosome; genetics; metabolism; mutation; pathogenicity; procedures English 2021 2021-01-18 10.1186/s12866-020-02083-0 바로가기 바로가기 바로가기 바로가기
Article Urban Type Classification and Characteristic Analysis through Time-Series Environmental Changes for Land Use Management for 31 Satellite Cities around Seoul, South Korea The objective of the present study was to determine changes in land coverage for 31 satellite cities surrounding Seoul and changes in values of MSPA (Morphological Spatial Pattern Analysis) for a time period of about 30 years (from 1988 to 2018). Cities that showed similar environmental changes were grouped utilizing a hierarchical cluster analysis. The results of this study are summarized as follows: First, as a result of analyzing changes in land coverage, urbanized areas in all 31 cities greatly increased, whereas areas of forest, grassland, farmland, wetland, etc., greatly decreased. Second, as a result of carrying out MSPA for green areas in each city, the number of Cores, Islets as stepping-stone green areas, and Branches greatly decreased. As a result of analyzing factors in cluster analysis, 12 variables were classified into four groups. After performing a cluster analysis, the 31 cities were classified into six clusters. Cluster-6 showed the biggest decrease in wetland areas. These results could be used as basic data for establishing differentiated environmental policies for clusters of cities that show similar environmental changes, and for establishing policy priorities that break away from uniform environmental policies at the local level. Kim, Jin-Hyo; Kwon, Oh-Sung; Ra, Jung-Hwa Korea Forest Conservat Assoc, Div Forestland Spatial Planning, Daejeon 35262, South Korea; Gyeonggi Res Inst, Dept Ecol & Environm, Suwon 16207, South Korea; Kyungpook Natl Univ, Dept Landscape Architecture, Daegu 41566, South Korea 57226774198; 57226769032; 57226765126 gsjhk@kfca.re.kr;kos8282@gri.re.kr;jhra@knu.ac.kr; LAND LAND-BASEL 2073-445X 10 8 SSCI ENVIRONMENTAL STUDIES 2021 3.905 43.4 0.8 2025-07-30 10 12 land-cover change; MSPA; cluster analysis; land use management WILDLIFE CROSSING STRUCTURES; COVER CHANGE; LANDSCAPE; ECOLOGY; INDEXES; PATCH Cluster analysis; Land use management; Land-cover change; MSPA English 2021 2021-08 10.3390/land10080799 바로가기 바로가기 바로가기 바로가기
Article Characterization of an Antibacterial Agent Targeting Ferrous Iron Transport Protein FeoB against Staphylococcus aureus and Gram-Positive Bacteria The emergence of multidrug-resistant Staphylococcus aureus strains has become a serious clinical problem. Iron is absolutely required for the bacterial growth, virulence associated with colonization, and survival from the host immune system. The FeoB protein is a major iron permease in bacterial ferrous iron transport systems (Feo) that has been shown to play a crucial role in virulence of some pathogenic bacteria. However, FeoB is still uncharacterized in Gram-positive pathogens, and its effects on S. aureus pathogenesis are unknown. In this study, we identified a novel inhibitor, GW3965 center dot HCl, that targets FeoB in S. aureus. The molecule effectively inhibited FeoB in vitro enzyme activity, bacterial growth, and virulence factor expression. Genome-editing and metabolomic analyses revealed that GW3965 center dot HCl inhibited FeoB function and affected the associated mechanisms with reduced iron availability in S. aureus. Gentamicin resistance and Caenorhabditis elegans infection assays further demonstrated the power of GW3965 center dot HCl as a safe and efficient antibacterial agent. In addition to S. aureus, GW3965 center dot HCl also presented its effectiveness on inhibition of the FeoB activity and growth of Gram-positive bacteria. This novel inhibitor will provide new insight for developing a next-generation antibacterial therapy. Shin, Minhye; Jin, Yerin; Park, Jinsub; Mun, Daye; Kim, Soo Rin; Payne, Shelley M.; Kim, Kyoung Heon; Kim, Younghoon Korea Univ, Grad Sch, Dept Biotechnol, Seoul 02841, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Dept Agr Biotechnol, Seoul 08826, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Univ Texas Austin, Coll Nat Sci, Dept Mol Biosci, Austin, TX 78712 USA ; Kim, Soo Rin/X-2192-2019; Kim, Kyoung Heon/F-1059-2013; Kim, Duck-Hyun/ABI-5920-2020 57208401604; 57195262295; 57215932541; 57220577766; 36659584200; 7202815712; 34770896300; 57861979600 khekim@korea.ac.kr;ykeys2584@snu.ac.kr; ACS CHEMICAL BIOLOGY ACS CHEM BIOL 1554-8929 1554-8937 16 1 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY 2021 4.634 43.6 0.95 2025-07-30 14 15 X-RECEPTOR AGONIST; LXR AGONIST; FATTY-ACIDS; ANTIBIOTICS; VIRULENCE; MANGANESE; IDENTIFICATION; BIOSYNTHESIS; ACQUISITION; MECHANISMS Animals; Anti-Bacterial Agents; Bacterial Proteins; Benzoates; Benzylamines; Biological Transport; Caenorhabditis elegans; Drug Resistance, Bacterial; Ferrous Compounds; Gentamicins; Gram-Positive Bacteria; Staphylococcus aureus; 3 [3 [[2 chloro 3 (trifluoromethyl)benzyl](2 diphenylethyl)amino]propoxy]phenylacetic acid; antiinfective agent; iron binding protein; protein feob; unclassified drug; antiinfective agent; bacterial protein; benzoic acid; benzylamine derivative; ferrous ion; gentamicin; antibiotic therapy; Article; bacterial growth; bacterial virulence; Caenorhabditis elegans; drug targeting; gene editing; gentamicin resistance; Gram positive bacterium; in vitro study; nonhuman; priority journal; protein expression; Staphylococcus aureus; animal; antibiotic resistance; chemistry; drug effect; Gram positive bacterium; growth, development and aging; metabolism; Staphylococcus aureus; transport at the cellular level English 2021 2021-01-15 10.1021/acschembio.0c00842 바로가기 바로가기 바로가기 바로가기
Meeting Abstract A qualitative study of the psychosocial distress of health care workers during the COVID-19 outbreak Lee, So Hee; Lee, Ju-yeon; Lee, Ji Yeon; Kim, Jang Rae; Park, Hye Yoon; Kim, Yeonjae; Kwon, Ki Tae Natl Med Ctr, Dept Psychiat, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Psychiat, Seoul, South Korea; Hankuk Univ Foreign Studies, Grad Sch Educ, Dept Conselling, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Psychiat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea Kim, Hanjin/KYP-2633-2024; Lee, Jung-Seok/L-6826-2019 ASIA-PACIFIC PSYCHIATRY ASIA-PAC PSYCHIAT 1758-5864 1758-5872 13 SCIE;SSCI PSYCHIATRY 2021 3.788 43.7 0 English 2021 2021-04 바로가기 바로가기
Meeting Abstract Comparison of face emotional recognition deficits in remitted schizophrenia and euthymic bipolar I disorder Bae, Min Jae; Jin, Bo Hyun; Rim, Hyo-Deog; Won, Seunghee Kyungpook Natl Univ Hosp, Dept Psychiat, Daegu, South Korea ASIA-PACIFIC PSYCHIATRY ASIA-PAC PSYCHIAT 1758-5864 1758-5872 13 SCIE;SSCI PSYCHIATRY 2021 3.788 43.7 0 English 2021 2021-04 바로가기 바로가기
Meeting Abstract Exploring the neurobiology of OCD through the concept of thought-action fusion Lee, Sang Won Kyungpook Natl Univ, Chilgok Hosp, Dept Psychiat, Daegu, South Korea ASIA-PACIFIC PSYCHIATRY ASIA-PAC PSYCHIAT 1758-5864 1758-5872 13 SCIE;SSCI PSYCHIATRY 2021 3.788 43.7 0 English 2021 2021-04 바로가기 바로가기
Article Relationship between symptoms and both stage of change in adopting a healthy life style and quality of life in patients with liver cirrhosis: a cross-sectional study Background Previous studies of patients with liver cirrhosis have not considered the broad range of symptoms or the association between healthy behavior and quality of life. The purposes of this study were to examine the association between symptoms and adopting exercise and consuming fruits and vegetables and to identify factors associated with quality of life in patients with liver cirrhosis. Methods This cross-sectional study enrolled 91 consecutive patients with liver cirrhosis in one tertiary general hospital in South Korea between February 2016 and January 2017. Each study participant completed a self-administered questionnaire that measured symptom, stage of change in engaging in exercise and consumption of fruits and vegetables, and the Korean version of the 36-item Short-Form Health Survey. Multivariate ordinal logistic regression analysis and multiple regression models was used, respectively, to examine the association between each symptom with stage of change in engaging in exercise and consumption of fruits and vegetables and to evaluate factors affecting quality of life. Results Experiencing nausea was associated with more readiness for change in engaging in exercise, but experiencing shortness of breath was associated with less readiness for change in engaging in exercise. Experiencing right upper quadrant pain was associated with more readiness for change in engaging in consumption of fruits and vegetables. Muscle cramps, anorexia, right upper quadrant pain and body pain, itching, ascites or edema, bruising, and change in appearance negatively affected quality of life. Conclusions The results suggest that the types of symptoms experienced by a patient with liver cirrhosis hinder or promote the patient's adoption of exercise and dietary behavior. Experiencing symptoms may negatively affect quality of life. Caregivers should provide supportive care to patients with liver cirrhosis, which includes assessing and managing symptoms to improve quality of life. Lee, Myung Kyung; Chung, Woo Jin Kyungpook Natl Univ, Coll Nursing, Res Inst Nursing Sci, 680 Gukchabosangro, Daegu 41944, South Korea; Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea 40661513200; 55741230500 mlee@knu.ac.kr; HEALTH AND QUALITY OF LIFE OUTCOMES HEALTH QUAL LIFE OUT 1477-7525 19 1 SCIE;SSCI HEALTH CARE SCIENCES & SERVICES;HEALTH POLICY & SERVICES 2021 3.077 43.8 0.49 2025-07-30 6 5 Symptom; Exercise; Diet; Quality of life; Liver cirrhosis EXERCISE-INDUCED NAUSEA; PHYSICAL-ACTIVITY; CANCER-TREATMENT; MUSCLE CRAMPS; RECOMMENDATIONS; ASSOCIATIONS; NUTRITION Diet; Exercise; Liver cirrhosis; Quality of life; Symptom Adult; Aged; Aged, 80 and over; Attitude to Health; Cross-Sectional Studies; Exercise Therapy; Female; Healthy Lifestyle; Humans; Liver Cirrhosis; Logistic Models; Male; Middle Aged; Multivariate Analysis; Quality of Life; Republic of Korea; Severity of Illness Index; Surveys and Questionnaires; Symptom Assessment; adult; aged; anorexia; Article; ascites; attitude to health; attitude to illness; caregiver support; controlled study; contusion; cross-sectional study; disease association; dyspnea; edema; exercise; female; fruit consumption; healthy lifestyle; human; lifestyle modification; liver cirrhosis; major clinical study; male; middle aged; muscle cramp; nausea; patient care; physical appearance; pruritus; quality of life; questionnaire; Short Form 36; South Korea; symptom; upper abdominal pain; vegetable consumption; attitude to health; kinesiotherapy; liver cirrhosis; multivariate analysis; psychology; quality of life; severity of illness index; statistical model; symptom assessment; very elderly English 2021 2021-05-17 10.1186/s12955-021-01787-9 바로가기 바로가기 바로가기 바로가기
Article Synthesis of gelation-induced emissive, o-phenylazonaphthol-based organogel and its responsiveness to fluoride anion Type your Abstract text here An organogelator based on o-phenylazonaphthol (o-AN) was synthesized to achieve gelation-induced emission using the resultant organogel. Although the o-AN-containing organogelator did not fluoresce in solution, its resulting organogel became red fluorescent. The fluorescence originated from the aggregation-induced emissive property of o-AN. The structural planarization, required for gelation was induced by the intramolecular hydrogen bond of the o-AN in the organogelator, leading to an intermolecular pi-pi interaction. The gelation was also facilitated by the non-covalent interaction of the van der Waals force. The gelation was investigated in terms of a molecular packing model and the organogel fluorescence. The organogel collapsed upon exposure to the fluoride anion, because the hydroxyl group of the o-AN was deprotonated, resulting in a weakened hydrogen bond and, finally, the disappearance of fluorescence. The organogel is potentially promising for applications such as ion sensing and stimuli-responsiveness-related fields. (C) 2020 Elsevier Ltd. All rights reserved. Jo, Seonyoung; Ahn, Hyungju; Park, Soo-Young; Lee, Taek Seung Chungnam Natl Univ, Dept Organ Mat Engn, Organ & Optoelect Mat Lab, Daejeon 34134, South Korea; Pohang Accelerator Lab, Beamline Res Div, Pohang 37673, Gyeongbuk, South Korea; Kyungpook Natl Univ, Dept Polymer Sci, Daegu 41566, South Korea park, soo-young/N-3170-2017; Ahn, Hyungju/AAT-6251-2021 55791481200; 56452216500; 57194041850; 8243217900 tslee@cnu.ac.kr; TETRAHEDRON TETRAHEDRON 0040-4020 1464-5416 81 SCIE CHEMISTRY, ORGANIC 2021 2.388 43.8 0.57 2025-07-30 11 10 o-phenylazonaphthol; Gelation-induced emission; Organogel; Fluorescence; Fluoride anion Fluorescence; Fluoride anion; Gelation-induced emission; o-phenylazonaphthol; Organogel anion; dichloromethane; fluoride; hydroxyl group; organogel; Article; chemical modification; chemical structure; deprotonation; fluorescence analysis; gelation; hydrogen bond; molecular interaction; proton nuclear magnetic resonance English 2021 2021-02-12 10.1016/j.tet.2020.131895 바로가기 바로가기 바로가기 바로가기
Review 2020 Korean guidelines for the management of metastatic prostate cancer In 2017, Korean Society of Medical Oncology (KSMO) published the Korean management guideline of metastatic prostate cancer. This paper is the 2nd edition of the Korean management guideline of metastatic prostate cancer. We updated recent many changes of management in metastatic prostate cancer in this 2nd edition guideline. The present guideline consists of the three categories: management of metastatic hormone sensitive prostate cancer; management of metastatic castration resistant prostate cancer; and clinical consideration for treating patients with metastatic prostate cancer. In category 1 and 2, levels of evidence (LEs) have been mentioned according to the general principles of evidence-based medicine. And grades of recommendation (GR) was taken into account the quality of evidence, the balance between desirable and undesirable effects, the values and preferences, and the use of resources and GR were divided into strong recommendations (SR) and weak recommendations (WR). A total of 16 key questions are selected. And we proposed recommendations and described key evidence for each recommendation. The treatment landscape of metastatic prostate cancer is changing very rapid and many trials are ongoing. To verify the results of the future trials is necessary and should be applied to the treatment for metastatic prostate cancer patients in the clinical practice. Especially, many prostate cancer patients are old age, have multiple underlying medical comorbidities, clinicians should be aware of the significance of medical management as well as clinical efficacy of systemic treatment.Y Kim, In-Ho; Shin, Sang Joon; Kang, Byung Woog; Kang, Jihoon; Kim, Dalyong; Kim, Miso; Kim, Jin Young; Kim, Chan Kyu; Kim, Hee-Jun; Maeng, Chi Hoon; Park, Kwonoh; Park, Inkeun; Bae, Woo Kyun; Sohn, Byeong Seok; Lee, Min-Young; Lee, Jae Lyun; Lee, Junglim; Lim, Seung Taek; Lim, Joo Han; Chang, Hyun; Jung, Joo Young; Choi, Yoon Ji; Kim, Young Seok; Cho, Jaeho; Joung, Jae Young; Park, Se Hoon; Lee, Hyo Jin Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Div Med Oncol,Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Div Oncol, Coll Med, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Oncol Hematol, Daegu, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Hematol Oncol,Sch Med, Seoul, South Korea; Dongguk Univ, Dept Internal Med, Div Hematol & Med Oncol, Ilsan Hosp, Goyang, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Div Hematol Oncol, Seoul, South Korea; Keimyung Univ, Div Hematooncol, Dongsan Hosp, Daegu, South Korea; Soonchunhyang Univ, Dept Internal Med, Div Hematol & Oncol, Bucheon Hosp, Bucheon, South Korea; Chung Ang Univ, Dept Internal Med, Div Hematol Oncol, Coll Med, Seoul, South Korea; Kyung Hee Univ Hosp, Dept Internal Med, Div Med Oncol Hematol, Seoul, South Korea; Pusan Natl Univ, Dept Internal Med, Yangsan Hosp, Med Oncol & Hematol, Yangsan, South Korea; Gachon Univ, Dept Internal Med, Div Med Oncol, Gil Med Ctr, Incheon, South Korea; Chonnam Natl Univ, Dept Hematooncol, Hwasun Hosp, Hwasun, South Korea; Inje Univ, Dept Internal Med, Sanggye Paik Hosp, Seoul, South Korea; Soonchunhyang Univ, Dept Internal Med, Div Hematol & Oncol, Seoul Hosp, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Oncol & Internal Med, Coll Med, Seoul, South Korea; Daegu Fatima Hosp, Dept Internal Med, Div Med Oncol, Daegu, South Korea; Yonsei Univ, Dept Oncol, Wonju Coll Med, Wonju, South Korea; Inha Univ, Dept Hematol Oncol, Sch Med, Incheon, South Korea; Catholic Kwandong Univ, Div Med Oncol, Int St Marys Hosp, Coll Med, Incheon, South Korea; Hallym Univ, Div Hematooncol, Dongtan Sacred Heart Hosp, Hwaseong, South Korea; Korea Univ, Dept Med, Div Hematol Oncol, Anam Hosp, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Radiat Oncol, Coll Med, Seoul, South Korea; Yonsei Univ, Yonsei Canc Ctr, Dept Radiat Oncol, Coll Med, Seoul, South Korea; Natl Canc Ctr, Ctr Urol Canc, Goyang, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Hematol Oncol,Sch Med, Seoul, South Korea; Chungnam Natl Univ, Dept Internal Med, Coll Med, 282 Munhwa Ro, Daejeon 35015, South Korea CHO, JAEHO/JWO-2429-2024; Lee, Jae Lyun/AGI-4843-2022; Kim, Jin Il/JWP-3629-2024; Kim, Tae/B-9921-2013; Maeng, Chi/AAI-8539-2020; Park, Eun/W-1340-2019; Kim, Seok-Hwan/G-9981-2015; Kim, Youngsun/AAY-5946-2021; JY, LEE/GRS-9767-2022; Park, Se Hoon/GMX-1199-2022 55477690000; 7403647334; 28567838500; 55759474000; 55011483500; 55193756000; 57196169650; 56267062300; 57203630724; 57188154100; 54885558200; 25947690900; 14028001300; 17137510400; 57196096704; 7601475983; 16203096000; 59067164900; 24168642900; 58105873900; 56540455000; 57195968893; 57040026600; 55231352500; 57222985702; 25960261300; 35409594900 cymed@cnu.ac.kr; KOREAN JOURNAL OF INTERNAL MEDICINE KOREAN J INTERN MED 1226-3303 2005-6648 36 3 SCIE MEDICINE, GENERAL & INTERNAL 2021 3.165 43.9 0.19 2025-07-30 7 6 Practice guideline; Prostate neoplasms ANDROGEN-DEPRIVATION THERAPY; SMALL-CELL CARCINOMA; MITOXANTRONE PLUS PREDNISONE; RANDOMIZED CONTROLLED-TRIAL; PAINFUL BONE METASTASES; POST HOC ANALYSIS; PHASE-III TRIAL; GETUG-AFU 15; ZOLEDRONIC ACID; OPEN-LABEL Practice guideline; Prostate neoplasms Humans; Male; Prostatic Neoplasms; Republic of Korea; abiraterone; apalutamide; cabazitaxel; darolutamide; denosumab; docetaxel; enzalutamide; estrogen; gonadorelin antagonist; placebo; prednisone; radium chloride ra 223; tamoxifen; zoledronic acid; allergic reaction; androgen deprivation therapy; awareness; bone metastasis; cancer grading; cancer patient; cancer radiotherapy; cardiovascular disease; clinical feature; clinical practice; clinician; comorbidity; depression; diabetes mellitus; diarrhea; drug efficacy; drug safety; drug use; electrolyte disturbance; erectile dysfunction; evidence based practice; fatigue; groups by age; gynecomastia; hot flush; human; hypertension; hypertransaminasemia; hypothyroidism; mental disease; metastasis; metastatic castration resistant prostate cancer; neutropenia; obesity; orchiectomy; osteoporosis; patient care; patient monitoring; peripheral neuropathy; phase 3 clinical trial (topic); practice guideline; prostate cancer; randomized controlled trial (topic); rash; Review; seizure; stomatitis; male; prostate tumor; South Korea English 2021 2021-05 10.3904/kjim.2020.213 바로가기 바로가기 바로가기 바로가기
Article A Prospective Study of the Efficacy of Cell-Assisted Lipotransfer with Stromal Vascular Fraction to Correct Contour Deformities of the Autologous Reconstructed Breast Background Autologous lipotransfer has increasingly become popular for breast reconstruction. Moreover, owing to the emergence of information regarding the efficacy of stromal vascular fraction (SVF) in terms of oncological safety and survival rate, procedures based on cell-assisted lipotransfer (CAL) have been widely employed recently. However, quantitative data of CAL with SVF are lacking. We evaluated the efficacy of CAL using SVF on survival rate in breast reconstruction. Methods A 12-month prospective study was conducted for 20 patients (20 breasts) requiring breast asymmetry correction due to volume deficit following autologous breast reconstruction using a transverse rectus abdominis myocutaneous flap or latissimus dorsi flap after total mastectomy. After the patients were equally divided into two groups-fat graft with SVF (Group 1, n = 10) and without SVF (Group 2, n = 10)-, the variance of breast volume was measured using three-dimensional scanning to analyze fat graft retention rate. Moreover, patient satisfaction and complications were investigated. Results Fat graft retention rate was higher in Group 1 than in Group 2 at both postoperative 6 months (73.8% vs. 62.2%; p = 0.03) and 12 months (65.4% vs. 48.4%; p = 0.03). Group 1 showed higher patient satisfaction. Regarding complications, fat necrosis occurred in 1 patient each in both groups. However, locoregional recurrence was not observed in any patient during follow-up. Conclusions CAL with SVF is effective in increasing survival rates of autologous fat grafts for correction of volume deficit after breast reconstruction. Moreover, it is associated with improved patient satisfaction in terms of the esthetic aspect. Jeon, Hyeon Jun; Choi, Dong Hun; Lee, Jung Ho; Lee, Joon Seok; Lee, Jeeyeon; Park, Ho Yong; Yang, Jung Dug Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Leaders Plast Surg Clin, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea Yang, Jung/R-7806-2019; Lee, Jungho/AAJ-7137-2020; PARK, JUN-YOUNG/P-5981-2015; Lee, Jong-Mok/KVY-9550-2024; LEE, JIN/Q-3108-2018 57201068256; 58587903800; 57202925792; 56496041000; 37079213100; 56564377200; 55171704700 lambyang@knu.ac.kr; AESTHETIC PLASTIC SURGERY AESTHET PLAST SURG 0364-216X 1432-5241 45 3 SCIE SURGERY 2021 2.708 43.9 2.98 2025-07-30 22 23 Autologous lipotransfer; Stromal vascular fraction; Breast volumetry; Three-dimensional scanning CANCER PATIENTS; SUPPORTIVE USE; STEM-CELLS; IN-VITRO; FAT; AUGMENTATION; SAFETY; TISSUE Autologous lipotransfer; Breast volumetry; Stromal vascular fraction; Three-dimensional scanning Adipose Tissue; Breast Neoplasms; Humans; Mammaplasty; Mastectomy; Neoplasm Recurrence, Local; Prospective Studies; Retrospective Studies; Treatment Outcome; adipose tissue; breast reconstruction; breast tumor; human; mastectomy; prospective study; retrospective study; treatment outcome; tumor recurrence English 2021 2021-06 10.1007/s00266-020-01981-y 바로가기 바로가기 바로가기 바로가기
Article Clinical characteristics and survival of colorectal cancer patients in Korea stratified by age Background/Aims: This nationwide study was undertaken to determine differences in clinicopathologic characteristics and survival of patients with colorectal cancer (CRC) according to age using big data from the Korean National Health Insurance Service (NHIS). Methods: The NHIS data including quality assessment of CRC by the Health Insurance Review & Assessment Service in Korea between 2011 and 2014 were analyzed. Based on age, patients were divided into three groups: not-old patients (= 75 years old). Results: We included 71,513 CRC patients. The median follow-up duration was 3.2 years (range, 0.003 to 5.5). Male patients constituted 60%. The median age of patients was 65 years (range, 18 to 102). Colon was the cancer site in 59.8% of not-old patients, 62.9% of young-old patients, and 66.1% of old-old patients. Compared to not-old patients, young-old and old-old patients were more likely to be diagnosed with colon adenocarcinoma and well/moderate differentiation or adequate differentiation (all p < 0.001). Old patients underwent more emergency operation (p < 0.001) and received less adjuvant therapy in stage I-III (p<0.001). The probability of 3-year survival of young-old or old-old patients was worse than that for not-old patients (hazard ratio [HR], 1.55; 95% confidence interval [CI], 1.46 to 1.64) (HR, 3.19; 95% CI, 3.03 to 3.37). Conclusions: Old patients with CRC show different histology from younger patients. They are more frequently to have colon as primary lesion. They undergo less adjuvant therapy. Further studies and evidence-based guidelines for older patients with CRC are warranted to improve their outcome. Baek, Sun Kyung; Lee, Ji Sung; Hwang, In Gyu; Kim, Jong Gwang; Kim, Tae Won; Sohn, Seung Kook; Kang, Mi Yeon; Lee, Sang-Cheol Kyung Hee Univ Hosp, Dept Internal Med, Seoul, South Korea; Asan Med Ctr, Clin Res Ctr, Seoul, South Korea; Chung Ang Univ Hosp, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Med Ctr, Dept Oncol Hematol, Daegu, South Korea; Univ Ulsan, Asan Med Ctr, Dept Oncol, Coll Med, Seoul, South Korea; Hlth Insurance Review & Assessment Serv, Wonju, South Korea; Hlth Insurance Review & Assessment Serv, Qual Assessment Management Div, Wonju, South Korea; Soonchunhyang Univ, Dept Internal Med, Cheonan Hosp, Cheonan, South Korea Kim, Tae Won/GRX-7323-2022 36631425100; 57212925539; 7201614898; 59501049300; 56504151300; 57214581136; 57212602700; 56596320900 leptin72@gmail.com; KOREAN JOURNAL OF INTERNAL MEDICINE KOREAN J INTERN MED 1226-3303 2005-6648 36 4 SCIE MEDICINE, GENERAL & INTERNAL 2021 3.165 43.9 0.37 2025-07-30 6 6 Colorectal cancer; Elderly; Histology; Survival III COLON-CANCER; ELDERLY-PATIENTS; EMERGENCY-SURGERY; STATISTICS; CHEMOTHERAPY; OXALIPLATIN; PREVALENCE; MORTALITY; THERAPY; SAFETY Colorectal cancer; Elderly; Histology; Survival Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Combined Modality Therapy; Humans; Male; Middle Aged; Proportional Hazards Models; Republic of Korea; Young Adult; adenocarcinoma; adolescent; adult; aged; colorectal tumor; human; male; middle aged; multimodality cancer therapy; proportional hazards model; South Korea; very elderly; young adult English 2021 2021-07 10.3904/kjim.2019.066 바로가기 바로가기 바로가기 바로가기
Article Clinical risk factors and pattern of initial fungal contamination in endoscopic biopsy-derived gastrointestinal cancer organoid culture Background/Aims: Because gastrointestinal tract is not sterile, primary culture has contamination risk despite of massive washing with antimicrobial media. Microbial contamination can play a key role in initial failure during biopsy-derived primary tumor culture. Methods: Tumor tissue was acquired from esophageal and gastric tumors using endoscopic biopsy. Three-dimensional cultures were performed, and separated spheroids were cultured in media for 7 to 10 days and then transferred to Matrigel (Corning Inc.). We investigated risk factors and patterns of initial fungal contamination. Results: Initial tumor contamination was observed in 23% (7/30) of esophageal cancer and 20% (3/15) of gastric cancer samples. Two cases of bacterial contamination occurred during the establishment of culture protocol. Moderate to thick whitish plaques (p < 0.001) and food retention in lumen (p < 0.001) were risk factors for initial fungal contamination. After exclusion of high risk patients for contamination, no fungal contamination occurred in primary organoid cultures. Fungal contamination was usually detected within 3 days after tumor preparation. However, unusual fungal contamination (GC11 and EC29) was recognized after several passages. Growing spherical shapes resembled cancer organoids. Although they rapidly proliferated and multiple daughter spheroids appeared, the media were translucent. After several passages, yeasts and pseudohyphae were detected on the edges of the solid spherical structures and media. Conclusions: Moderate to thick whitish plaques and food retention are clinical risk factors for initial fungal contamination during biopsy-derived cancer organoid culture. Most initial fungal contamination was detected within 3 days, but it could be unusually recognized after several passages. Nam, Su Youn; Lee, Seung Jin; Lim, Hee Jung; Park, Ji Young; Jeon, Seong Woo Kyungpook Natl Univ Hosp, Ctr Gastr Canc, Dept Gastroenterol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea Jeon, Seongwoo/AAU-4618-2020 55617028500; 57226403382; 57226394759; 57210160197; 9733636500 nam20131114@gmail.com; KOREAN JOURNAL OF INTERNAL MEDICINE KOREAN J INTERN MED 1226-3303 2005-6648 36 4 SCIE MEDICINE, GENERAL & INTERNAL 2021 3.165 43.9 0.46 2025-07-30 7 6 Organoids; Gastric cancer; Esophageal cancer; Biopsy; Contamination CANDIDA; CELL; VIRULENCE Biopsy; Contamination; Esophageal cancer; Gastric cancer; Organoids Biopsy; Esophageal Neoplasms; Humans; Organoids; Risk Factors; Stomach Neoplasms; biopsy; esophagus tumor; human; organoid; risk factor; stomach tumor English 2021 2021-07 10.3904/kjim.2020.474 바로가기 바로가기 바로가기 바로가기
Article Colonoscopy quality in community hospitals and nonhospital facilities in Korea Background/Aims: High-quality colonoscopy is essential to reduce colorectal cancer-related deaths. Little is known about colonoscopy quality in non-academic practice settings. We aimed to evaluate the quality of colonoscopies performed in community hospitals and nonhospital facilities. Methods: Colonoscopy data were collected from patients referred to six tertiary care centers after receiving colonoscopies at community hospitals and nonhospital facilities. Based on their photographs, we measured quality indicators including cecal intubation rate, withdrawal time, adequacy of bowel preparation, and number of polyps. Results: Data from a total of 1,064 colonoscopies were analyzed. The overall cecal intubation rate was 93.1%. The median withdrawal time was 8.3 minutes, but 31.3% of colonoscopies were withdrawn within 6 minutes. Community hospitals had longer withdrawal time and more polyps than nonhospital facilities (median withdrawal time: 9.9 minutes vs. 7.5 minutes, p < 0.001; mean number of polyps: 3.1 vs. 2.3, p = 0.001). Board-certified endoscopists had a higher rate of cecal intubation than non-board-certified endoscopists (93.2% vs. 85.2%, p = 0.006). A total of 819 follow-up colonoscopies were performed at referral centers with a median interval of 28 days. In total, 2,546 polyps were detected at baseline, and 1,088 were newly identified (polyp miss rate, 29.9%). Multivariable analysis revealed that older age (odds ratio [OR], 1.032; 95% confidence interval [CI], 1.020 to 1.044) and male sex (OR, 1.719; 95% CI, 1.281 to 2.308) were associated with increased risk of missed polyps. Conclusions: The quality of colonoscopies performed in community hospitals and nonhospital facilities was suboptimal. Systematic reporting, auditing, and feedback are needed for quality improvement. Lee, Jae Gon; Han, Dong Soo; Joo, Young-Eun; Myung, Dae-Seong; Park, Dong Il; Kim, Seul Ki; Jung, Yunho; Lee, Won Hyun; Kim, Eun Soo; Yoon, Joon Seok; Eun, Chang Soo Hanyang Univ, Dept Internal Med, Guri Hosp, 153 Gyeongchun Ro, Guri 11923, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Sch Med, Seoul, South Korea; Soonchunhyang Univ, Dept Internal Med, Coll Med, Cheonan, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea Lee, Jae Gon/AAE-7558-2022; Kim, Yong Won/AAA-2134-2022; Han, Dong Soo/AHD-6285-2022; Kim, Sang/J-5398-2012 57002275200; 14621423900; 7102315439; 23135423100; 56524839700; 57200015190; 54789008200; 57222362674; 57203086704; 57222358034; 7004074626 hands@hanyang.ac.kr; KOREAN JOURNAL OF INTERNAL MEDICINE KOREAN J INTERN MED 1226-3303 2005-6648 36 SCIE MEDICINE, GENERAL & INTERNAL 2021 3.165 43.9 0.27 2025-07-30 4 3 Colonoscopy; Quality improvement; Community hospital; Ambulatory care facilities CANCER SCREENING-PROGRAM; COLORECTAL-CANCER; ADENOMA DETECTION; MISS RATE; INDICATORS; PREVENTION; RISK Ambulatory care facilities; Colonoscopy; Community hospital; Quality improvement Aged; Cecum; Colonic Polyps; Colonoscopy; Colorectal Neoplasms; Hospitals, Community; Humans; Male; Republic of Korea; adult; age; aged; Article; certification; colon polyp; colonoscopy; community hospital; controlled study; digestive tract intubation; endoscopist; female; follow up; health care facility; health care quality; human; intestine preparation; major clinical study; male; missed diagnosis; nonhospital facility; risk factor; sex; tertiary care center; cecum; colon polyp; colonoscopy; colorectal tumor; community hospital; South Korea English 2021 2021-03 10.3904/kjim.2019.117 바로가기 바로가기 바로가기 바로가기
Article Comparison of antimicrobial resistances and clinical features in community-onset Escherichia coli and Klebsiella pneumoniae bacteremia Background/Aims: The aim of this study was to compare antimicrobial resistance, clinical features, and outcomes of community-onset Escherichia coli (COEC) and Klebsiella pneumoniae (COKP) bacteremia. Methods: The medical records of patients diagnosed with E. coli or K. pneumoniae bacteremia in the emergency department of a 750-bed secondary care hospital in Daegu, Korea from January 2010 to December 2016 were retrospectively reviewed. Results: A total of 866 patients with COEC bacteremia and 299 with COKP bacteremia were enrolled. COEC bacteremia, compared to COKP bacteremia, had higher rates of 3rd generation cephalosporin (3GC) (18.8% vs. 8.4%, p < 0.001) and fluoroquinolone (FQ) (30.4% vs. 8.0%, p < 0.001) resistance. The patients with COKP bacteremia had higher Charlson comorbidity indices (CCI) (1.8 +/- 2.0 vs. 1.5 +/- 1.8, p = 0.035), Pittsburgh bacteremia scores (PBS) (2.0 +/- 2.6 vs. 1.3 +/- 1.8, p < 0.001), and 30-day mortality (14.44% vs. 8.8%, p = 0.008) than the patients with COEC bacteremia. Age younger than 70 years, male sex, polymicrobial infections, pneumonia, intra-abdominal infection, PBS = 2, and Foley catheter insertion were independent predictive factors for COKP bacteremia compared to COEC bacteremia in the multivariate analysis. CCI, PBS, and intensive care unit admission were independent risk factors for 30-day mortality in the multivariate analysis. Conclusions: 3GCs and FQs are still useful for the empirical treatment of patients with probable COKP bacteremia. The patients with COKP bacteremia had worse outcomes because of its greater severity and more frequent underlying comorbidities. Sung, Hwa Seok; Lee, Je Won; Bae, Sohyun; Kwon, Ki Tae Daegu Fatima Hosp, Dept Emergency Med, Daegu, South Korea; Keimyung Univ, Dept Emergency Med, Grad Sch, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, 807 Hoguk Ro, Daegu 41404, South Korea Hwang, Soyoon/HHM-5762-2022 57222359673; 57222362794; 57219699506; 9733850500 ktkwon@knu.ac.kr; KOREAN JOURNAL OF INTERNAL MEDICINE KOREAN J INTERN MED 1226-3303 2005-6648 36 2 SCIE MEDICINE, GENERAL & INTERNAL 2021 3.165 43.9 0.18 2025-07-30 3 3 Cephalosporins; Quinolone; Comorbidity; Mortality INFECTIONS Cephalosporins; Comorbidity; Mortality; Quinolone Aged; Anti-Bacterial Agents; Bacteremia; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Republic of Korea; Retrospective Studies; Risk Factors; amikacin; ampicillin; aztreonam; cefazolin; cefepime; cephalosporin; cotrimoxazole; imipenem; piperacillin plus tazobactam; quinoline derived antiinfective agent; sultamicillin; antiinfective agent; abdominal infection; age; aged; antibiotic resistance; antimicrobial therapy; Article; bacteremia; cephalosporin resistance; Charlson Comorbidity Index; chronic liver disease; clinical feature; cohort analysis; coinfection; community onset Escherichia coli bacteremia; community onset Klebsiella pneumoniae bacteremia; controlled study; disease severity; emergency ward; female; fluoroquinolone resistance; hospital admission; human; intensive care unit; major clinical study; male; mortality rate; multivariate analysis; Pittsburgh bacteremia score; pneumonia; retrospective study; risk factor; secondary care center; sex; South Korea; survival rate; ulcer; urinary tract infection; antibiotic resistance; bacteremia; Escherichia coli; Escherichia coli infection; Klebsiella infection; Klebsiella pneumoniae English 2021 2021-03 10.3904/kjim.2019.272 바로가기 바로가기 바로가기 바로가기
Article Defensive behavior of the invasive alien hornet, Vespa velutina, against color, hair and auditory stimuli of potential aggressors Background: During recent years, invasion of the yellow-legged hornet (Vespa velutina) has occurred in Europe, Korea and Japan, and stinging accidents often occur as some V. velutina nests are in places where humans can reach them. Misleading information regarding precautionary measures for mitigating wasp attacks has only exacerbated the situation. In this study, we sought to identify appropriate countermeasures by analyzing wasp defensive behavior, with a focus on color, hair and auditory stimuli. Methods: Defensive behavior was analyzed using video recordings by creating an experimental frame to attach experimental bundles to nine V. velutina nests in Daegu and Gyeongbuk, South Korea. For the color experiment, eight-color and single-color tests were conducted with bundles of eight colors (black, brown, yellow, green, orange, gray, red and white), and the difference in defensive behavior was tested between black hair/hairless and green hair/black hairless configurations. Results: When presented simultaneously with bundles of eight different colors, V. velutina showed the greatest and the longest defensive behavior against the black bundle, followed by brown. A similar response was observed in single-color tests. Furthermore, there was no significant difference in the defensive behavior against black hair and black hairless, but the duration of defensive behavior was longer for black hair. A comparison between green hair and black hairless stimuli indicated that wasps are more sensitive to color than to hair texture. Vespa velutina showed no discernible responses when exposed to selected auditory stimuli (human conversation and loud music). Dark colors and dark hair are characteristic features of potential predators, to which wasps are evolutionarily predisposed, and are accordingly likely to provoke strong defensive responses. The results of this study provide scientifically credible information that can be used to base appropriate precautionary measures against wasp attacks. Choi, Moon Bo; Hong, Eui Jeong; Kwon, Ohseok Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea; Natl Inst Ecol, Team Natl Ecosyst Survey, Seocheon Gun, South Korea 51863232400; 57219217435; 56323648400 kosinchoi@hanmail.net;ecoento@knu.ac.kr; PEERJ PEERJ 2167-8359 9 SCIE MULTIDISCIPLINARY SCIENCES 2021 3.061 43.9 0.51 2025-07-30 4 7 Colour; Hair; Natural enemy; Noise; Vespa velutina Colour; Hair; Natural enemy; Noise; Vespa velutina Textures; Video recording; Auditory stimuli; Color stimulus; Color test; Defensive behavior; Hair; Misleading informations; Natural enemies; Noise; Precautionary measures; Vespa velutina; article; color vision test; controlled study; conversation; defensive behavior; hair texture; human; music; natural enemy; noise; nonhuman; predator; South Korea; Vespa velutina; videorecording; wasp; Color English 2021 2021-04-06 10.7717/peerj.11249 바로가기 바로가기 바로가기 바로가기
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