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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Genetic Analysis of Zoonotic Gastrointestinal Protozoa and Microsporidia in Shelter Cats in South Korea | Feral cats that are roaming outside can serve as reservoirs for zoonotic pathogens, negatively impacting public health. They may experience high levels of parasitic infection. Some gastrointestinal protozoa and microsporidia possessing zoonotic potential in cats include Cryptosporidium spp., Giardia duodenalis, Blastocystis sp., Enterocytozoon bieneusi, and Toxoplasma gondii. Here, we show the infection rates and risk factors of intestinal protozoa and microsporidia detected from shelter cats on Jeju Island in South Korea in 2020. Among 158 cats, we detected genes for five internal protozoa and microsporidia, namely, Cryptosporidium felis (0.6%), G. duodenalis (3.8%), Blastocystis sp. (0.6%), E. bieneusi (3.8%), and T. gondii (1.3%). Furthermore, 16 cats (10.1%) were PCR-positive for at least one protozoan or microsporidium. To our knowledge, this study is the first to describe the existence of C. felis, G. duodenalis assemblage F, Blastocystis sp. ST4 subtype, and E. bieneusi genotype Peru11 in cats in South Korea. Despite the small number of positive samples, this study expands our understanding of the incidence of zoonotic gastrointestinal protozoa and microsporidia in shelter cats and genetically characterizes the isolates found in the infected animals. Moreover, these findings emphasize the need for a better control strategy on protozoa and microsporidia in cats, tailored to their individual needs, to protect animal and public health. | Kwak, Dongmi; Seo, Min-Goo | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea; Anim & Plant Quarantine Agcy, Vet Drugs & Biol Div, Gimcheon 39660, South Korea | ; Seo, Min-Goo/NQF-4335-2025 | 7007148758; 53982155300 | dmkwak@knu.ac.kr;koreasmg@korea.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 9 | 11 | SCIE | MICROBIOLOGY | 2020 | 3.492 | 48.9 | 1.26 | 2025-06-25 | 30 | 25 | cat; Cryptosporidium felis; Giardia duodenalis; Blastocystis sp; Enterocytozoon bieneusi; Toxoplasma gondii | TOXOPLASMA-GONDII INFECTION; GIARDIA-DUODENALIS; ENTEROCYTOZOON-BIENEUSI; BLASTOCYSTIS SUBTYPES; CRYPTOSPORIDIUM SPP.; FERAL CATS; IDENTIFICATION; GENOTYPE; STRAY; DOGS | Blastocystis sp; Cat; Cryptosporidium felis; Enterocytozoon bieneusi; Giardia duodenalis; Toxoplasma gondii | RNA 16S; Article; Blastocystis; cat; child; cloning; controlled study; Cryptosporidium; DNA extraction; Escherichia coli; female; Fusarium oxysporum; genetic analysis; genotype; Giardia intestinalis; human; incidence; intestinal protozoa; major clinical study; male; Microsporidia; molecular diagnosis; nonhuman; nucleotide sequence; nucleotide sequence; parasite identification; parasitosis; phylogenetic tree; phylogeny; polymerase chain reaction; prevalence; protozoon; risk factor; sample size; sequence alignment; sequence analysis; sequence homology; South Korea; Toxoplasma gondii; zoonotic transmission | English | 2020 | 2020-11 | 10.3390/pathogens9110894 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Genetic Diversity and Zoonotic Potential of Blastocystis in Korean Water Deer, Hydropotes inermis argyropus | Blastocystis is a protozoan parasite commonly detected in the intestinal tract of humans and animals. It has been actively studied worldwide; however, information on Blastocystis is limited in Korea. Because there is an increasing concern about the contact between wildlife and domestic animals or humans, we assessed the infection status and zoonotic potential of Blastocystis in Korean water deer (KWD, Hydropotes inermis argyropus) using genotyping and phylogenetic analysis. A total of 125 fresh fecal samples were collected from KWD which were killed by vehicles on highways or roadsides in this study. Among the 125 samples, 51 (40.8%) were PCR positive. We performed nucleotide sequencing and phylogenetic analysis of 26 of the 51 PCR-positive samples. By analyzing Blastocystis 18S rRNA, two subtypes (ST4 and ST14) were identified in this study. Of the 26 samples analyzed, 25 were identified as ST14 and one as ST4. Infection of ST14 in humans has not been reported. Although only one ST4 sample was detected in this study, ST4 has zoonotic potential without showing ruminant specificity. Thus, continuous attention should be provided to the potential of transmission between wildlife and domestic animals and humans. | Kim, Kyoo-Tae; Noh, Gyeonguk; Lee, Haeseung; Kim, Seon-Hee; Jeong, Hyesung; Kim, Yongkwan; Jheong, Weon-Hwa; Oem, Jae-Ku; Kim, Tae-Hwan; Kwon, Oh-Deog; Kwak, Dongmi | Daejeon O World, Anim Hlth Ctr Zoo Land, Daejeon 35073, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu 41566, South Korea; Natl Inst Environm Res, Environm Hlth Res Dept, Incheon 22689, South Korea; Jeonbuk Natl Univ, Coll Vet Med, Dept Vet Med, Jeonbuk 54596, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea | ; kim, juhee/HKV-6163-2023; Kim, Yong-kwan/LIC-0165-2024 | 56680415000; 57220040287; 57202497862; 59627742600; 57213935791; 57193715617; 24076289900; 6506283913; 57202984578; 7402195886; 7007148758 | zoovet@dcco.kr;ku0207@naver.com;lhspppp@naver.com;sunny14@korea.kr;halley@korea.kr;kyk5388@korea.kr;purify@korea.kr;jku0623@jbnu.ac.kr;thkim56@knu.ac.kr;odkwon@knu.ac.kr;dmkwak@knu.ac.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 9 | 11 | SCIE | MICROBIOLOGY | 2020 | 3.492 | 48.9 | 0.63 | 2025-06-25 | 13 | 12 | Blastocystis; Hydropotes inermis argyropus; Korean water deer; phylogeny; subtype; wildlife animal | ZOO ANIMALS; LIVESTOCK; SUBTYPES; SPP. | Blastocystis; Hydropotes inermis argyropus; Korean water deer; Phylogeny; Subtype; Wildlife animal | genomic DNA; RNA 18S; agar gel electrophoresis; Article; Blastocystis; controlled study; deer; DNA extraction; feces analysis; female; genetic variability; genotype; male; nonhuman; nucleotide sequence; phylogeny; real time polymerase chain reaction; zoonosis | English | 2020 | 2020-11 | 10.3390/pathogens9110955 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Genetic Diversity of Bovine Hemoprotozoa in South Korea | Tick-borne pathogens cause economically significant diseases in cattle.Theileriaspp. are parasitic protozoa and the causative agent of bovine theileriosis. Here we report the distribution and risk factors of bovineTheileriausing blood samples taken between 2018 and 2019. Of 737 tested cattle, nine animals (1.2%) were positive forTheileria orientalisinfection by 18S rRNA gene amplification. Further analysis of the infected samples using theT. orientalismajor piroplasm surface protein (MPSP) gene revealed five different genotypes circulating in the population: Types 1, 2, 3, 7, and N3. To the best of our knowledge, this is the first research to describe the existence of theT. orientalisMPSP genotype N3 in South Korea. Although the prevalence of bovineT. orientaliswas low, our study offers data on the geographical distribution and prevalence of bovineTheileriaspp. in South Korea. Further studies are warranted to determine the correlation of clinical symptoms with parasite MPSP genotypes. Our data provide epidemiological information to help control bovine theileriosis in South Korea. | Kwak, Dongmi; Seo, Min-Goo | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea; Anim & Plant Quarantine Agcy, Vet Drugs & Biol Div, Gyeongbuk 39660, South Korea | ; Seo, Min-Goo/NQF-4335-2025 | 7007148758; 53982155300 | dmkwak@knu.ac.kr;koreasmg@korea.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 9 | 9 | SCIE | MICROBIOLOGY | 2020 | 3.492 | 48.9 | 0.13 | 2025-06-25 | 4 | 4 | cattle; piroplasm; phylogeny; Theileria | THEILERIA-ORIENTALIS INFECTION; PIROPLASM SURFACE PROTEIN; GRAZING CATTLE; PHYLOGENETIC ANALYSIS; TICKS | Cattle; Phylogeny; Piroplasm; Theileria | membrane protein; piroplasm surface protein; RNA 18S; unclassified drug; Article; blood parasite; bovine; DNA extraction; female; gene amplification; genetic variability; genotype; geographic distribution; male; nonhuman; nucleotide sequence; nucleotide sequence; phylogeny; Piroplasmida; polymerase chain reaction; risk factor; sequence analysis; single nucleotide polymorphism; South Korea; Theileria; theileriosis; tick borne disease | English | 2020 | 2020-09 | 10.3390/pathogens9090768 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Heterotrimeric G-Protein Signalers and RGSs in Aspergillus fumigatus | The heterotrimeric G-protein (G-protein) signaling pathway is one of the most important signaling pathways that transmit external signals into the inside of the cell, triggering appropriate biological responses. The external signals are sensed by various G-protein-coupled receptors (GPCRs) and transmitted into G-proteins consisting of the alpha, beta, and gamma subunits. Regulators of G-protein signaling (RGSs) are the key controllers of G-protein signaling pathways. GPCRs, G-proteins, and RGSs are the primary upstream components of the G-protein signaling pathway, and they are highly conserved in most filamentous fungi, playing diverse roles in biological processes. Recent studies characterized the G-protein signaling components in the opportunistic pathogenic fungus Aspergillus fumigatus. In this review, we have summarized the characteristics and functions of GPCRs, G-proteins, and RGSs, and their regulatory roles in governing fungal growth, asexual development, germination, stress tolerance, and virulence in A. fumigatus. | Park, Hee-Soo; Kim, Min-Ju; Yu, Jae-Hyuk; Shin, Kwang-Soo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA; Konkuk Univ, Dept Syst Biotechnol, Seoul 05029, South Korea; Daejeon Univ, Grad Sch, Dept Microbiol, Daejeon 34520, South Korea | ; Park, Hee-Soo/AAC-6422-2019; Yu, Jae-Hyuk/A-2343-2008; Kim, Min-Ju/NGS-6870-2025 | 15751448400; 57204454148; 7405531243; 13310380600 | phsoo97@knu.ac.kr;13mjkim@gmail.com;jyu1@wisc.edu;shinks@dju.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 9 | 11 | SCIE | MICROBIOLOGY | 2020 | 3.492 | 48.9 | 0.42 | 2025-06-25 | 19 | 19 | Aspergillus fumigatus; regulators of G-protein signaling; virulence; G-protein; G-protein-coupled receptors | COUPLED RECEPTOR; ASEXUAL SPORULATION; REGULATORS; GROWTH; FLBA; PATHOGENESIS; ACTIVATION; EXPRESSION; VIRULENCE; UPSTREAM | Aspergillus fumigatus; G-protein; G-protein-coupled receptors; Regulators of G-protein signaling; Virulence | FlbA protein; G protein coupled receptor; GprK protein; heterotrimeric guanine nucleotide binding protein; reactive oxygen metabolite; RGS protein; RgsA protein; RgsB protein; RgsC protein; RgsD protein; unclassified drug; virulence factor; alpha chain; amino acid sequence; antifungal activity; Aspergillus fumigatus; beta chain; cell differentiation; enzyme activity; fermentation; filamentous fungus; fungal virulence; fungus growth; gene overexpression; genetic analysis; germination; morphogenesis; nonhuman; oxidative stress; phenotype; physiological stress; protein targeting; Review; signal transduction; temperature stress; ubiquitination | English | 2020 | 2020-11 | 10.3390/pathogens9110902 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Molecular and Phylogenetic Analysis of Tick-Borne Pathogens in Ticks Parasitizing Native Korean Goats (Capra hircus coreanae) in South Korea | Tick-borne pathogens (TBPs) are considered zoonotic re-emerging pathogens, with ticks playing important roles in their transmission and ecology. Previous studies in South Korea have examined TBPs residing in ticks; however, there is no phylogenetic information on TBPs in ticks parasitizing native Korean goat (NKG; Capra hircus coreanae). The present study assessed the prevalence, risk factors, and co-infectivity of TBPs in ticks parasitizing NKGs. In total, 107 hard ticks, including Haemaphysalis longicornis, Ixodes nipponensis, and Haemaphysalis flava, were obtained from NKGs in South Korea between 2016 and 2019. In 40 tested tick pools, genes for four TBPs, namely Coxiella-like endosymbiont (CLE, 5.0%), Candidatus Rickettsia longicornii (45.0%), Anaplasma bovis (2.5%), and Theileria luwenshuni (5.0%) were detected. Ehrlichia, Bartonella spp., and severe fever with thrombocytopenia syndrome virus were not detected. To our knowledge, this is the first study to report CLE and T. luwenshuni in H. flava ticks in South Korea. Considering the high prevalence of Candidatus R. longicornii in ticks parasitizing NKGs, there is a possibility of its transmission from ticks to animals and humans. NKG ticks might be maintenance hosts for TBPs, and we recommend evaluation of the potential public health threat posed by TBP-infected ticks. | Seo, Min-Goo; Kwon, Oh-Deog; Kwak, Dongmi | Anim & Plant Quarantine Agcy, Vet Drugs & Biol Div, 177 Hyeoksin 8 Ro, Gimcheon 39660, Gyeongbuk, South Korea; Kyungpook Natl Univ, Coll Vet Med, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, 680 Gukchaebosang Ro, Daegu 41944, South Korea | ; Seo, Min-Goo/NQF-4335-2025 | 53982155300; 7402195886; 7007148758 | koreasmg@korea.kr;odkwon@knu.ac.kr;dmkwak@knu.ac.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 9 | 2 | SCIE | MICROBIOLOGY | 2020 | 3.492 | 48.9 | 0.75 | 2025-06-25 | 15 | 14 | tick-borne pathogens; phylogeny; Rickettsia; Theileria; Anaplasma; Coxiella; tick | ANAPLASMA; BARTONELLA; CATTLE; WORLD; IDENTIFICATION; RICKETTSIOSES; INFECTIONS; PREVALENCE; DISEASES; ANIMALS | Anaplasma; Coxiella; Phylogeny; Rickettsia; Theileria; Tick; Tick-borne pathogens | Anaplasma bovis; Article; Bartonella; Candidatus; Capra hircus coreanae; Ehrlichia; goat; Haemaphysalis flava; Haemaphysalis longicornis; Ixodes nipponensis; molecular biology; nonhuman; nucleotide sequence; phylogeny; prevalence; public health; risk factor; South Korea; Theileria luwenshuni; tick; tick borne disease | English | 2020 | 2020-02 | 10.3390/pathogens9020071 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Molecular Detection and Genetic Characteristics of Equine Herpesvirus in Korea | Respiratory diseases cause significant economic losses (especially in the horse racing industry). The present study describes the detection and genetic characteristics of equine herpesvirus (EHV) from a total of 1497 samples from clinically healthy horses in Korea, including 926 blood samples, 187 lung tissues, and 384 nasal swabs. EHV-2 and EHV-5 were detected in 386 (41.7%; 95% CI: 38.5-44.9) and 201 (21.7%; 95% CI: 19.1-24.4) blood samples, respectively, and in 25 (13.4%; 95% CI: 8.5-18.2) and 35 (18.7%; 95% CI: 13.1-24.3) lung tissues, respectively. EHV-1 and EHV-4 were not detected in either blood or lung tissues. EHV-1, EHV-2, and EHV-5 were detected in 46 (12.0%; 95% CI: 8.7-15.2), 21 (5.5%; 95% CI: 3.2-7.7), and 43 (11.2%; 95% CI: 8.0-14.4) nasal swabs, respectively. EHV-4 was not detected in nasal swabs. Co-infection with EHV-2 and EHV-5 was detected in 11.6% (107/926) of the blood samples and 6.4% (12/187) of lung tissues. In nasal swabs, co-infection with EHV-1, EHV-2, and EHV-5 was detected in 0.8% (3/384) of samples. Phylogenetic analysis of the glycoprotein B gene showed that EHV-1, EHV-2, and EHV-5 strains demonstrated significant genetic diversity in Korea, with a nucleotide sequence identity among them that ranged from 95.7% to 100% for EHV-1, 96.2-100% for EHV-2, and 93.8-99.3% for EHV-5. These results are the first phylogenetic analyses of EHV-1 in Korea in nasal swabs from a nationwide population of clinically healthy horses. Both EHV-2 and EHV-5 from blood, lung tissues, and nasal swabs were also detected. | Seo, Min-Goo; Ouh, In-Ohk; Lee, Sang Kyu; Lee, Jong-Seok; Kwon, Oh-Deog; Kwak, Dongmi | Anim & Plant Quarantine Agcy, 177 Hyeoksin 8 Ro, Gimcheon, Gyeongbuk, South Korea; Kyungpook Natl Univ, Coll Vet Med, 80 Daehakro, Daegu 41566, South Korea; Korea Racing Author, Equine Epidem Control & Quarantine Sect, Gwacheon 13822, Gyeonggi, South Korea; Korea Mil Acad, Horse Riding Mil Unit, Seoul 01805, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea | Seo, Min-Goo/NQF-4335-2025; LEE, SEJUE/KMX-1267-2024 | 53982155300; 56096229500; 35192153800; 57216154459; 7402195886; 7007148758 | koreasmg@korea.kr;dvmoio@korea.kr;bestvet@kra.co.kr;cryboy85@naver.com;odkwon@knu.ac.kr;dmkwak@knu.ac.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 9 | 2 | SCIE | MICROBIOLOGY | 2020 | 3.492 | 48.9 | 0.44 | 2025-06-25 | 9 | 10 | herpesvirus; horse; EHV-1; EHV-2; EHV-5; phylogeny | RESPIRATORY-DISEASE; SEQUENCE-ANALYSIS; HORSES; IDENTIFICATION; INFECTIONS; VIRUSES; MARES; SWABS | EHV‐1; EHV‐2; EHV‐5; Herpesvirus; Horse; Phylogeny | genomic DNA; glycoprotein B; animal tissue; Article; blood sampling; controlled study; DNA extraction; Equid herpesvirus 1; equine herpesvirus 2; Equine Herpesvirus 5; female; gene sequence; genetic variability; glycoprotein B gene; herpes virus infection; horse; lung parenchyma; male; mixed infection; molecular cloning; nonhuman; nose smear; nucleotide sequence; phylogeny; polymerase chain reaction; South Korea; viral genetics; virus detection; virus gene; virus strain | English | 2020 | 2020-02 | 10.3390/pathogens9020110 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Seroprevalence and Molecular Characterization of Coxiella burnetii in Cattle in the Republic of Korea | This study was conducted to determine the prevalence of Coxiella burnetii in cattle and how that prevalence is influenced by cattle breed and growth type. A total of 491 cattle [cattle breed: 216 dairy cattle and 275 beef cattle; growth type: indoor housed (n = 294) and grazing (n = 197)] were used. The presence of C. burnetii DNA and antibodies was detected from blood and serum samples using polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The overall prevalence of C. burnetii was: 10.8% (95% CI: 8.0-13.5%) using PCR and 8.8% (95% CI: 6.3-11.3%) using ELISA. The prevalence of C. burnetii was significantly higher in beef cattle than in dairy cattle using both PCR (13.5% vs. 7.4%; P = 0.032) and ELISA (14.5% vs. 1.4%; P = 0.000), respectively. Comparison by growth type revealed that C. burnetii infection was significantly higher in grazing cattle than in housed cattle when using both PCR (24.9% vs. 1.4%; P = 0.000) and ELISA (21.3% vs. 0.3%; P = 0.000). Beef cattle were at a significantly higher risk of contracting C. burnetii compared with dairy cattle (odds ratio = 3.20, 95% CI: 1.80-5.67; P = 0.000). The risk of contracting C. burnetii in grazing cattle was increased by 32.57-fold (95% CI: 12.84-82.61; P = 0.000) compared with indoor housed cattle. The phylogenetic analysis based on the IS1111 gene revealed that our sequences grouped with human, tick, goat, and cattle isolates/strains found in several countries. C. burnetii sequences circulating in the Republic of Korea exhibit genetic variations. Thus, grazing is a high risk factor for the prevalence and transmission of C. burnetii. | Hwang, Sunwoo; Cho, Hyung-Chul; Shin, Seung-Uk; Kim, Ha-Young; Park, Yu-Jin; Jang, Dong-Hoon; Kim, Eun-Mi; Kim, Jong Wan; Park, Jinho; Choi, Kyoung-Seong | Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Horse Compan & Wild Anim, Sangju 37224, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Anim & Plant Quarantine Agcy, Bacterial Dis Div, Gimcheon 39660, South Korea; Jeonbuk Natl Univ, Coll Vet Med, Iksan 54596, South Korea | 57217125669; 57219427000; 56967385500; 53877655700; 57219426539; 57219727115; 57219722950; 56313003400; 8730126700; 7403949556 | hdh123111@naver.com;gudcjf246@naver.com;shinws95@naver.com;kimem256@naver.com;ujp1506@naver.com;janginsect@naver.com;biotics@korea.kr;jpark@jbnu.ac.kr;kschoi3@knu.ac.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 9 | 11 | SCIE | MICROBIOLOGY | 2020 | 3.492 | 48.9 | 0.25 | 2025-06-25 | 6 | 7 | Coxiella burnetii; dairy cattle; beef cattle; grazing; ELISA; IS1111 | Q-FEVER; DAIRY-CATTLE; RISK-FACTORS; RAW-MILK; INFECTION; DIAGNOSIS; RUMINANTS | Beef cattle; Coxiella burnetii; Dairy cattle; ELISA; Grazing; IS1111 | animal experiment; animal tissue; article; beef cattle; cattle breed; controlled study; Coxiella burnetii; dairy cattle; enzyme linked immunosorbent assay; genetic variation; goat; grazing; nonhuman; phylogeny; polymerase chain reaction; risk factor; seroprevalence; serum; South Korea; tick | English | 2020 | 2020-11 | 10.3390/pathogens9110890 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Synergism of the Combination of Traditional Antibiotics and Novel Phenolic Compounds against Escherichia coli | Pathogenic Escherichia coli (E. coli)-associated infections are becoming difficult to treat because of the rapid emergence of antibiotic-resistant strains. Novel approaches are required to prevent the progression of resistance and to extend the lifespan of existing antibiotics. This study was designed to improve the effectiveness of traditional antibiotics against E. coli using a combination of the gallic acid (GA), hamamelitannin, epicatechin gallate, epigallocatechin, and epicatechin. The fractional inhibitory concentration index (FICI) of each of the phenolic compound-antibiotic combinations against E. coli was ascertained. Considering the clinical significance and FICI, two combinations (hamamelitannin-erythromycin and GA-ampicillin) were evaluated for their impact on certain virulence factors of E. coli. Finally, the effects of hamamelitannin and GA on Rattus norvegicus (IEC-6) cell viability were investigated. The FICIs of the antibacterial combinations against E. coli were 0.281-1.008. The GA-ampicillin and hamamelitannin-erythromycin combinations more effectively prohibited the growth, biofilm viability, and swim and swarm motilities of E. coli than individual antibiotics. The concentration of hamamelitannin and GA required to reduce viability by 50% (IC50) in IEC-6 cells was 988.54 mu M and 564.55 mu M, correspondingly. GA-ampicillin and hamamelitannin-erythromycin may be potent combinations and promising candidates for eradicating pathogenic E. coli in humans and animals. | Hossain, Md. Akil; Park, Hae-Chul; Park, Sung-Won; Park, Seung-Chun; Seo, Min-Goo; Her, Moon; Kang, JeongWoo | Anim & Plant Quarantine Agcy, Vet Drugs & Biol Div, Gimcheon Si 39660, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Bukgu 41566, Daegu, South Korea; Korea Ctr Dis Control & Prevent, Div Vectors & Parasit Dis, Cheongju 28159, South Korea | ; Park, Sung-Won/AEL-2300-2022; Seo, Min-Goo/NQF-4335-2025; Park, Seung-Chun/AAV-3388-2021; Hossain, Akil/AAY-7229-2020 | 55754133800; 57210463034; 55803248200; 7501832396; 53982155300; 23989046000; 57212201397 | mdakil_hossain@yahoo.com;sungpark@korea.kr;pasawa@korea.kr;parksch@knu.ac.kr;koreasmg@korea.kr;herm@mail.go.kr;hijach@korea.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 9 | 10 | SCIE | MICROBIOLOGY | 2020 | 3.492 | 48.9 | 1.13 | 2025-06-25 | 29 | 30 | synergistic effect; antibacterial agents; bacterial pathogenicity; ampicillin; erythromycin | IN-VITRO; ANTIBACTERIAL ACTIVITY; CHEMICAL-COMPOSITION; SWARMING MOTILITY; BIOFILM FORMATION; LIVESTOCK; HAMAMELITANNIN; INHIBITION; MODULATION; RESISTANCE | Ampicillin; Antibacterial agents; Bacterial pathogenicity; Erythromycin; Synergistic effect | amoxicillin; ampicillin; antibiotic agent; cefotaxime; ceftiofur; ciprofloxacin; epicatechin; epicatechin gallate; epigallocatechin; florfenicol; fluconazole; gallic acid; gentamicin; imipenem; marbofloxacin; nitrofurantoin; norfloxacin; penicillin G; phenol derivative; posaconazole; tetracycline; thiamphenicol; virulence factor; agar dilution; antibacterial activity; antibiotic therapy; antifungal activity; Article; bacterium isolation; broth dilution; Candida albicans; cell viability; chicken; colony forming unit; combination drug therapy; confocal laser scanning microscopy; controlled study; cytotoxicity; disk diffusion; drug potentiation; Escherichia coli infection; feces analysis; fractional inhibitory concentration index; IC50; Listeria monocytogenes; microtiter plate assay; minimum inhibitory concentration; nonhuman; Rattus norvegicus; scanning electron microscopy; Staphylococcus aureus; tensile strength; traditional healer | English | 2020 | 2020-10 | 10.3390/pathogens9100811 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Extraction of intrinsic field-effect mobility of graphene considering effects of gate-bias-induced contact modulation | Carrier mobility is one of the most important parameters to evaluate the quality and uniformity of graphene. The mobility of graphene is typically extracted from the transconductance of a field-effect transistor fabricated with the graphene layer. However, the mobility value evaluated by this method is imprecise when the contact resistance is non-negligible, or the contact resistance is modulated by the gate bias, which is the case for typical graphene field-effect transistors. Here, we suggest a method for extracting the precise intrinsic field-effect mobility by considering the effective bias across the channel and its gate-induced modulation. We show that the contact resistances of typical graphene field-effect transistors are significantly modulated by gate bias and conventional methods can, therefore, cause a considerable error in the evaluation of the mobility. The proposed method in which the contact-induced error is removed gives a channel-length-independent intrinsic field-effect mobility. This method can be generally used to correctly evaluate the field-effect mobility of nano-scale or low-dimensional materials. | Lee, Chang-Ju; Park, Honghwi; Kang, Jaewoon; Lee, Junyeong; Choi, Muhan; Park, Hongsik | Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | ; Lee, Chang-Ju/W-8546-2019; Park, Honghwi/KIC-1871-2024 | 8943234400; 57206811785; 57207345841; 57210867037; 7402093793; 35366976200 | hpark@ee.knu.ac.kr; | JOURNAL OF APPLIED PHYSICS | J APPL PHYS | 0021-8979 | 1089-7550 | 127 | 18 | SCIE | PHYSICS, APPLIED | 2020 | 2.546 | 49.1 | 0.27 | 2025-06-25 | 7 | 5 | EFFECT TRANSISTORS; GRAIN-BOUNDARIES; RESISTANCE | Contact resistance; Electron mobility; Graphene; Graphene transistors; Hall mobility; Hole mobility; Modulation; Nanotechnology; Quality control; Channel length; Conventional methods; Field-effect mobilities; Graphene field-effect transistors; Graphene layers; Low-dimensional materials; Mobility value; Nano scale; Field effect transistors | English | 2020 | 2020-05-14 | 10.1063/1.5128050 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Photo- and electro-luminescence studies of semipolar (1122) InxAl1-xN | InxAl1-xN (0.15 2 ) free-standing GaN substrates by metal organic chemical vapor deposition. The emission characteristics of InxAl1-xN films and QWs were then investigated by photoluminescence (PL), cathodoluminescence (CL), and electroluminescence (EL). PL emission down at 1.87eV (similar to 660nm) was observed from In0.37Al0.63N at room temperature. However, its emission wavelength and spectral width showed almost no temperature-dependence, strongly suggesting the radiative recombination process in In0.37Al0.63N is heavily affected by the potential fluctuations associated with the defect levels such as deep donor-acceptor pairs (DAPs). For In0.23Al0.77N, the emission peaks at 3.24 and 2.4eV were observed at 300K but CL showed no evidence of compositional fluctuations. Given the wide spectral width and weak In clustering, PL at 3.24eV is likely from a shallow DAP transition involving an impurity-related shallow donor and valence band. PL emission at 2.4eV, on the other hand, behaved more like In0.37Al0.63N, suggesting significant deep DAP transitions. Both LEDs with In0.24Al0.76N and In0.28Al0.72N QWs showed a discrete blueshift of the emission peak with increasing injection current, which is very different from the gradual shift observed in InGaN LEDs. The high-energy peak was much narrower than the low-energy peak, suggesting it could be the near-band edge emission. Si doping of In0.24Al0.76N QWs lowered the injection current level at which the high-energy peak appears. | Chung, Roy Byung Kyu | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | 16642183100 | roy.b.chung@knu.ac.kr; | JOURNAL OF APPLIED PHYSICS | J APPL PHYS | 0021-8979 | 1089-7550 | 128 | 4 | SCIE | PHYSICS, APPLIED | 2020 | 2.546 | 49.1 | 0.2 | 2025-06-25 | 3 | 3 | PHOTOLUMINESCENCE; EMISSION; GROWTH; GAN | Electroluminescence; Gallium nitride; III-V semiconductors; Light; Metallorganic chemical vapor deposition; Organic chemicals; Organometallics; Semiconductor alloys; Semiconductor doping; Semiconductor quantum wells; Temperature distribution; Compositional fluctuations; Emission characteristics; Emission wavelength; Luminescence studies; Near band edge emissions; Potential fluctuations; Radiative recombination process; Temperature dependence; Aluminum compounds | English | 2020 | 2020-07-28 | 10.1063/5.0005247 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Synthesis of vanadium dioxide thin films and nanostructures | Vanadium oxides (VxOy) are classic "smart functional materials" used in a wide array of thermochromic, electronic, and catalytic applications. Specifically, vanadium dioxide (VO2) class nanomaterials are of enormous interest due to their unique first order reversible metal-insulator phase transition (MIT) behavior accompanied by a structural phase transition, inducing dramatic changes in electrical and optical properties with large lattice deformation. To date, a plethora of reports exemplifying the MIT characteristics of VO2, synthetic methods of VO2, and modulating VO2 phase transition temperatures (T-c) have been published. In this Tutorial Review, we present an overview on the fundamentals of the VO2 band structure and principles of MIT and outline various reported synthetic approaches for VO2 thin films, including dimensionally oriented VO2 nanostructures. Discussion on recent trends in VO2 applications, challenges in VO2 synthesis, and future perspectives are also elaborated in detail. | Devthade, Vidyasagar; Lee, Sangwook | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | Vidyasagar, Devthade/O-3930-2015; Lee, Sangwook/O-9166-2015 | wook2@knu.ac.kr; | JOURNAL OF APPLIED PHYSICS | J APPL PHYS | 0021-8979 | 1089-7550 | 128 | 23 | SCIE | PHYSICS, APPLIED | 2020 | 2.546 | 49.1 | 62 | METAL-INSULATOR-TRANSITION; CHEMICAL-VAPOR-DEPOSITION; PHASE-TRANSITION; THERMOCHROMIC VO2; HYDROTHERMAL SYNTHESIS; OPTICAL-PROPERTIES; METASTABLE PHASE; MOTT-HUBBARD; TEMPERATURE; GROWTH | English | 2020 | 2020-12-21 | 10.1063/5.0027690 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Effect of edaravone therapy in Korean amyotrophic lateral sclerosis (ALS) patients | Oxidative stress caused by free radicals has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Edaravone (also known as MCI-186), a free radical scavenger, was approved as an ALS treatment in 2015 in Japan. However, the therapeutic effects of edaravone on patients with ALS outside of Japan are not yet reported. This study aims to investigate effects of edaravone on ALS patients in the Korean population. The study included 22 patients with ALS who were treated with edaravone. Of the 16 patients who finished six cycles of treatment, a mean decline of ALSFRS-R after the treatments was 5.75 +/- 6.07 points and the average change of FVC was - 8.7 +/- 17.0%. Patients experienced only minor adverse events. This study reports on the open-label study of edaravone on patients in Korea for ALS patients, which showed a modest effect of edaravone in this population of ALS patients. | Park, Jin-Mo; Kim, Sun-Young; Park, Donghwi; Park, Jin-Sung | Dongguk Univ, Coll Med, Dept Neurol, Gyeongju Hosp, Gyeongju, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Neurol, Coll Med, Ulsan, South Korea; Daegu Fatima Hosp, Dept Rehabil, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, 807 Hoguk Ro, Daegu 41944, South Korea | ; Park, Donghwi/GYQ-6185-2022 | 55569003000; 57196226825; 56606561400; 44061744500 | neurojspark@gmail.com; | NEUROLOGICAL SCIENCES | NEUROL SCI | 1590-1874 | 1590-3478 | 41 | 1 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2020 | 3.307 | 49.3 | 2.63 | 2025-06-25 | 38 | 34 | Amyotrophic lateral sclerosis (ALS); Edaravone; Korean ALS; ALSFS-R | DOUBLE-BLIND; DECLINE; DISEASE | ALSFS-R; Amyotrophic lateral sclerosis (ALS); Edaravone; Korean ALS | Adult; Aged; Amyotrophic Lateral Sclerosis; Edaravone; Female; Free Radical Scavengers; Humans; Male; Middle Aged; Oxidative Stress; Republic of Korea; Treatment Outcome; norphenazone; riluzole; norphenazone; scavenger; adult; aged; amyotrophic lateral sclerosis; Article; aspiration pneumonia; body height; body mass; body weight; clinical article; constipation; disease duration; drug safety; female; forced expiratory volume; forced vital capacity; headache; human; insomnia; Korean (people); leukopenia; lung function; male; middle aged; multiple cycle treatment; observational study; onset age; open study; oxidative stress; pathogenesis; percutaneous endoscopic gastrostomy; therapy effect; amyotrophic lateral sclerosis; drug effect; metabolism; physiology; South Korea; treatment outcome | English | 2020 | 2020-01 | 10.1007/s10072-019-04055-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Electrochemical detection of 2,4,6-trinitrotoluene reduction in aqueous solution by using highly ordered 1D TiO2 nanotube arrays | In this work, we investigated the electrochemical behavior of TiO2 nanostructures in 2,4,6-trinitrotoluene contained aqueous solution. The TiO2 nanostructures were synthesized by anodization followed by crystallization with heat treatment. The morphology and crystal structures could be controlled by electrolyte of anodization and annealing temperatures. Compare to rutile phase, the anatase TiO2 nanotubes showed superior electrochemical reduction of 2,4,6-trinitrotoluene. Based on the results we also evaluated the feasibility of electrochemical 2,4,6-trinitrotoluene detection under variable environmental condition. | Moon, Sanghyeon; Nagappagari, Lakshmana Reddy; Lee, Jaewon; Lee, Hyeonkwon; Lee, Wonjoo; Lee, Kiyoung | Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, 2559 Gyeongsang Daero, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Inst Environm Sci & Technol, 80 Daehak Ro, Daegu, South Korea; Daeduk Univ, Div Mil Sci, 68 Gajeongbuk Ro, Daejeon 34111, South Korea | N, Dr. Lakshmana Reddy/K-2238-2019; Lee, Kiyoung/J-8680-2013; Nagappagari, Lakshmana Reddy/K-2238-2019 | 57217595243; 56499352000; 59830462300; 57208133419; 57215807492; 57219211501 | wjlee@ddu.ac.kr;kiyoung@knu.ac.kr; | MATERIALS TODAY COMMUNICATIONS | MATER TODAY COMMUN | 2352-4928 | 25 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 3.383 | 49.3 | 0.74 | 2025-06-25 | 18 | 17 | Functional; Porous materials; Anodization; TiO2 nanotube; 2,4,6-Trinitrotoluene; Sensors | GRAPHENE NANORIBBONS; MASS-SPECTROMETRY; SENSOR; NANOPARTICLES; EXPLOSIVES; SINGLE; TNT | 2,4,6-Trinitrotoluene; Anodization; Functional; Porous materials; Sensors; TiO<sub>2</sub> nanotube | Electrolytes; Electrolytic reduction; Nanotubes; Oxide minerals; Titanium dioxide; 2 ,4 ,6-trinitrotoluene; Annealing temperatures; Electrochemical behaviors; ELectrochemical detection; Electrochemical reductions; Environmental conditions; Morphology and crystal structures; TiO2 nanotube arrays; Chemical detection | English | 2020 | 2020-12 | 10.1016/j.mtcomm.2020.101389 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study | Introduction In the current study, we evaluated factors that increase the coronavirus disease (COVID-19) patient death rate by analyzing the data from two cohort hospitals. In addition, we studied whether underlying neurological diseases are risk factors for death. Methods In this retrospective cohort study, we included 103 adult inpatients (aged >= 18 years). We evaluated differences in demographic data between surviving and non-surviving COVID-19 patients. Results In a multivariate logistic analysis, age and the presence of chronic lung disease and Alzheimer's dementia (AD) were the only significant parameters for predicting COVID-19 non-survival (p < 0.05). However, hypertension, coronary vascular disease, dyslipidemia, chronic kidney disease, diabetes, and history of taking angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, as well as nonsteroidal anti-inflammatory drugs (NSAIDs), were not significantly associated with the death of COVID-19 patients. The optimal cutoff value obtained from the maximum Youden index was 70 (sensitivity, 80.77%; specificity, 61.04%), and the odds ratio of non-survival increased 1.055 fold for every year of age. Conclusions Clinicians should closely monitor and manage the symptoms of COVID-19 patients who are over the age of 70 years or have chronic lung disease or AD. | Hwang, Jong-moon; Kim, Ju-Hyun; Park, Jin-Sung; Chang, Min Cheol; Park, Donghwi | Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Yeungnam Univ, Dept Rehabil Med, Coll Med, Daegu, South Korea; Yeungnam Univ, Dept Phys Med & Rehabil, Coll Med, 317-1 Daemyungdong, Taegu 705717, South Korea; Univ Ulsan, Coll Med, Dept Phys Med & Rehabil, Ulsan Univ Hosp, 877 Bangeojinsunghwndo Ro, Ulsan 44033, South Korea | ; Chang, Min Cheol/AAE-2321-2022; Park, Donghwi/GYQ-6185-2022 | 56367634000; 57208450909; 44061744500; 23767019400; 56606561400 | wheel633@ynu.ac.kr;bdome@hanmail.net; | NEUROLOGICAL SCIENCES | NEUROL SCI | 1590-1874 | 1590-3478 | 41 | 9 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2020 | 3.307 | 49.3 | 6.42 | 2025-06-25 | 71 | 71 | COVID-19; Alzheimer's dementia; Chronic lung disease; Coronavirus | T-CELLS; CORONAVIRUS; INFLAMMATION; AGE | Alzheimer’s dementia; Chronic lung disease; Coronavirus; COVID-19 | Age Factors; Aged; Aged, 80 and over; Betacoronavirus; Cohort Studies; Coronavirus Infections; Female; Humans; Lung Diseases; Male; Middle Aged; Mortality; Nervous System Diseases; Pandemics; Pneumonia, Viral; Predictive Value of Tests; Republic of Korea; Retrospective Studies; Risk Factors; angiotensin receptor antagonist; dipeptidyl carboxypeptidase inhibitor; hydroxychloroquine sulfate; lopinavir plus ritonavir; nonsteroid antiinflammatory agent; oxiklorine; adult; aged; Alzheimer disease; Article; artificial ventilation; chronic kidney failure; chronic lung disease; cohort analysis; comorbidity; coronavirus disease 2019; diabetes mellitus; dyslipidemia; extracorporeal oxygenation; female; hospital patient; human; hypertension; major clinical study; male; mortality risk; neurologic disease; retrospective study; risk factor; South Korea; age; Betacoronavirus; clinical trial; Coronavirus infection; epidemiology; lung disease; middle aged; mortality; multicenter study; neurologic disease; pandemic; predictive value; risk factor; very elderly; virus pneumonia | English | 2020 | 2020-09 | 10.1007/s10072-020-04541-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Combinational inhibition of EGFR and YAP reverses 5-Fu resistance in colorectal cancer | Yes-associated protein (YAP) is a transcriptional coactivator that promotes cell proliferation, migration, and tissue homeostasis in colorectal cancer (CRC). Here, we established 5-Fu resistant CRC cell line (SW620R) and examined the role of YAP in chemotherapy resistance. We showed that YAP promoted cell proliferation, migration, and chemotherapy resistance in CRC. To increase efficacy of CRC treatment, we employed another therapeutic target EGFR which interacts with the upstream signaling molecules of YAP in Hippo pathway. Verteporfin, a YAP specific inhibitor, inhibits YAP activity by blocking the YAP-TEAD complex in the cell nucleus, and AG1478, an inhibitor of EGFR/ErbB1, induces the phosphorylation and degradation of YAP. We found that combinational inhibition of YAP by VP and AG1478 synergistically suppressed the CRC development and reversed chemotherapy resistance in vitro and in vivo. Therefore, our results demonstrated a novel therapeutic strategy, the combination of inhibitors targeting EGFR and YAP, to suppress and reverse chemotherapy resistance in colorectal cancer. | Huang, Changhao; Chen, Zihua; Yang, Chen; Chen, Lu; Lai, Chen; Zhang, Yingying; Yuan, Weijie; Jeong, Ji-Hak | Cent South Univ, Xiangya Hosp, Dept Gastrointestinal Surg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China; Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha 410008, Hunan, Peoples R China; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, 80 Daehak Ro, Daegu 41566, South Korea | ; Zhang, Yingying/HPH-6379-2023 | 57190050818; 23977374300; 57203149100; 57770647900; 56564549100; 57193823513; 56822842400; 55913671500 | csuxyywj@csu.edu.cn;jihakjeong@gmail.com; | JOURNAL OF CANCER | J CANCER | 1837-9664 | 11 | 18 | SCIE | ONCOLOGY | 2020 | 4.207 | 49.4 | 0.77 | 2025-06-25 | 13 | 14 | colorectal cancer; YAP; chemotherapy resistance; EGFR; 5-Fu | PATHWAY; GROWTH; 5-FLUOROURACIL; CELLS | 5-Fu; Chemotherapy resistance; Colorectal cancer; EGFR; YAP | 4 (3 chloroanilino) 6,7 dimethoxyquinazoline; epidermal growth factor receptor; fluorouracil; protein; tead protein; transcription factor; unclassified drug; verteporfin; yes associated protein; adjuvant therapy; adult; animal cell; animal experiment; animal model; animal tissue; Article; cancer combination chemotherapy; cancer inhibition; cancer recurrence; cancer resistance; cancer surgery; cancer survival; cell migration; cell nucleus; cell proliferation; colorectal cancer; colorectal surgery; controlled study; drug efficacy; drug potentiation; female; hippo signaling; human; human tissue; in vitro study; in vivo study; male; mouse; multiple cycle treatment; nonhuman; protein degradation; protein phosphorylation; protein protein interaction; radical resection; signal transduction; stomach mucosa; SW620 cell line; tumor depth | English | 2020 | 2020 | 10.7150/jca.44775 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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