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| ○ | ○ | Article | Association between obesity and cancer risk in adults with HIV in Korea | Introduction:This study aimed to investigate the association between obesity and cancer risk as well as site-specific cancer risks in adults with HIV using a nationwide health screening database in Korea.Methods:Of the 16,671 adults with a new diagnosis of HIV from 2004 to 2020, 456 incident cancer cases and 1814 individually matched controls by sex, year of birth, year of HIV diagnosis, and follow-up duration (1 : 4 ratio) were included in this nested case-control study. The association between obesity (BMI >= 25 kg/m2) and cancer risks was estimated and presented as odds ratios (ORs) and 95% confidence intervals (95% CIs).Results:Of the 456 cancer incident cases, there were 146 AIDS-defining cancer cases and 310 non-AIDS-defining cancer cases. Compared with nonobese adults with HIV, obese adults with HIV were at higher risk of non-AIDS-defining cancer (OR = 1.478, 95% CI = 1.118-1.955). Otherwise, the overall risk of AIDS-defining cancer (OR = 0.816, 95% CI = 0.520-1.279) and each type of AIDS-defining cancer (Kaposi sarcoma and non-Hodgkin's lymphoma) were not high in obese adults with HIV. Of the specific types of non-AIDS-defining cancers, obesity was associated with an increased risk of colorectal cancer (OR = 3.090, 95% CI = 1.110-8.604) and liver, bile duct, and pancreatic cancers (OR = 2.532, 95% CI = 1.141-5.617).Conclusion:Obesity, which is one of the important health concerns in HIV management, was associated with an increased risk of non-AIDS-defining cancer but not AIDS-defining cancer. | Jang, Yoonyoung; Kim, Taehwa; Choi, Yunsu; Ahn, Kyoung Hwan; Kim, Jung Ho; Seong, Hye; Kim, Youn Jeong; Kim, Shin-Woo; Choi, Jun Yong; Kim, Hyo Youl; Song, Joon Young; Choi, Hee Jung; Kim, Sang Il.; Sohn, Jang Wook; Chin, BumSik; Choi, Bo-Youl; Park, Boyoung | Hanyang Univ, Coll Med, Dept Prevent Med, 222 Wangsimni Ro, Seoul 04763, South Korea; Seoul Natl Univ, Dept Agr Econ & Rural Dev, Seoul, South Korea; Sungkyunkwan Univ, Dept Psychol, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, AIDS Res Inst, Coll Med, Seoul, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Internal Med, Incheon 21431, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Div Infect Dis, Wonju 220701, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Infect Dis,Seoul St Marys Hosp, Seoul, South Korea; Natl Med Ctr, Dept Internal Med, Div Infect Dis, Seoul, South Korea | KIM, TAEHWA/JUF-6615-2023; Choi, Jun/AEH-4018-2022; Kim, Jung/L-9791-2019; Kim, Sang-Il/AAO-7057-2020 | 57215137959; 57927285900; 57195931031; 57832526400; 56657199800; 57193717138; 58528853000; 8710731500; 57791298700; 56819456800; 57214400146; 57217262202; 58305384100; 7201641941; 7102658932; 57236918400; 57217335056 | hayejine@hanmail.net; | AIDS | AIDS | 0269-9370 | 1473-5571 | 38 | 9 | SCIE | IMMUNOLOGY;INFECTIOUS DISEASES;VIROLOGY | 2024 | 3.1 | 32.5 | 0 | 2025-05-07 | 1 | 1 | AIDS; AIDS-defining cancer; HIV; non-AIDS-defining cancer; obesity | ANTIRETROVIRAL THERAPY; INFECTION; MORTALITY; TRENDS; ERA | AIDS; AIDS-defining cancer; HIV; non-AIDS-defining cancer; obesity | Adult; Aged; Case-Control Studies; Female; HIV Infections; Humans; Incidence; Male; Middle Aged; Neoplasms; Obesity; Republic of Korea; Risk Assessment; Risk Factors; Young Adult; anti human immunodeficiency virus agent; acquired immune deficiency syndrome; adult; Article; bile duct cancer; cancer risk; case control study; colorectal cancer; controlled study; female; follow up; highly active antiretroviral therapy; human; Human immunodeficiency virus infection; Kaposi sarcoma; Korea; liver cancer; major clinical study; male; malignant neoplasm; non-Hodgkin lymphoma; obese patient; obesity; pancreas cancer; aged; complication; epidemiology; Human immunodeficiency virus infection; incidence; middle aged; neoplasm; risk assessment; risk factor; South Korea; young adult | English | 2024 | 2024-07-15 | 10.1097/qad.0000000000003904 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Blocking screw (pin) technique to achieve an acceptable reduction in intramedullary of subtrochanteric femoral fractures: indications, techniques, and clinical outcomes | Introduction Subtrochanteric femur fractures treated with intramedullary nails present biomechanical benefits, early weight-bearing, and reduced soft tissue damage, promoting bone union. However, improper reduction due to muscular forces and fragmented proximal bone increases nonunion risk. This study evaluates the efficacy of the blocking screw technique in preventing malalignment during intramedullary nailing Material and methods In cases of subtrochanteric femoral fractures where malalignment, such as varus and anterior angulation, was anticipated during intramedullary nailing, proper reduction was ensured using blocking screw technique on the proximal bone fragment from the coronal or sagittal plane. A retrospective analysis was conducted on 25 patients (14 males, 11 females; average age 55.12 years) who were followed up for more than 1 year. The postoperative neck-shaft angle, anterior angulation angle, and limb length discrepancy were compared radiologically with those on the healthy side, and the presence and duration of bone union were measured. The Harris hip score was used for functional evaluation, and complications, including infection, were analyzed. Results At the final follow-up, primary bone union was achieved in 21/25 patients (84%), with an average bone union time of 21.81 weeks (range, 14-42 weeks). Of the four nonunions, bone union was achieved in three cases through bone grafting and supplemental plating and in the other case through intramedullary exchange, supplemental plating, and bone grafting. The femoral neck-shaft angle and anterior angulation showed no statistically significant differences compared with the healthy side, with averages of - 1.15 degrees and - 1.4 degrees, respectively. The limb length discrepancy was an average of - 2.4 mm. Regarding functional outcomes, the Harris hip score averaged 89.52 points (range 82-94 points). Conclusions In subtrochanteric femoral fractures, the blocking screw technique effectively prevents malalignment during intramedullary nailing, ensuring not only appropriate reduction but also high bone union rates. | Yoon, Yong-Cheol; Oh, Chang-Wug; Kim, Joon-Woo; Seng, Daniel W. R.; Yoon, Sung-Hyuk; Kim, Hyun Woo | Gachon Univ, Coll Med, Trauma Ctr, Orthoped Trauma Div, Incheon, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Woodlands Hlth, Natl Healthcare Grp, Dept Orthoped Surg, Singapore, Singapore | Yong-Cheol, Yoon/HPD-8077-2023; Oh, Chang-Wug/AAO-4602-2021 | 37082544400; 22135834200; 22951329000; 57203278479; 56323207000; 24776221500 | cwoh@knu.ac.kr; | ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | ARCH ORTHOP TRAUM SU | 0936-8051 | 1434-3916 | 144 | 2 | SCIE | ORTHOPEDICS;SURGERY | 2024 | 2.1 | 32.5 | 0 | 2025-05-07 | 0 | 0 | Subtrochanteric femur fractures; Intramedullary nailing; Malalignment; Blocking screw technique | Blocking screw technique; Intramedullary nailing; Malalignment; Subtrochanteric femur fractures | Bone Nails; Bone Screws; Female; Femoral Fractures; Fracture Fixation, Intramedullary; Fracture Healing; Hip Fractures; Humans; Male; Middle Aged; Retrospective Studies; Treatment Outcome; adult; aged; Article; bone malformation; bone radiography; bone transplantation; clinical article; clinical outcome; computer assisted tomography; coronal parameter; female; femoral neck-shaft angle; femur subtrochanteric fracture; fracture healing; fracture of greater trochanter; fracture reduction; Harris hip score; human; intramedullary nailing; leg length inequality; male; middle aged; retrospective study; surgical technique; treatment indication; very elderly; femur fracture; fracture healing; hip fracture; procedures; treatment outcome | English | 2024 | 2024-02 | 10.1007/s00402-023-05156-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Border Zone Maybe Correlated with Radiation Necrosis After Radiosurgery in Metastatic Brain Tumor | - BACKGROUND: Radiation necrosis (RN) after stereotactic radiosurgery (SRS) in brain metastases has been extensively evaluated, and RN is correlated with various risk factors. However, no study comprehensively analyzed the correlation between RN and the border zones of the brain that are vulnerable to ischemia. We hypothesized that patients with tumors in the border zone are at high risk of RN. Hence, the current study aimed to assess the correlation between border zone lesions and RN, with consideration of other predetermined factors. - METHODS: This retrospective study included 117 patients with 290 lesions who underwent Gamma Knife SRS. Radiological and clinical analyses were performed to identify factors possibly correlated with RN. Notably, the lesion location was classified into 2 groups (border zone and nonborder zone) based on the blood supply. - RESULTS: In total, 22 (18.8%) patients with 22 (7.5%) lesions developed RN. Univariate analysis revealed a sigificant correlation between RN and external border zone lesions, second course of SRS administered at the same site of the previous SRS, prescribed dose, and tumor volume. Multivariate analysis showed that border zone lesions, second course of SRS at the same site of the previous SRS, and tumor volume were significantly correlated with RN. - CONCLUSIONS: Patients with tumors in the border zone are at high risk of RN. The potential risks of RN can be attributed hypothetically to hypoperfusion. Hence, the association between RN and border zone lesions seems reasonable. | Lee, Chaejin; Yoon, Sang-Youl; Hwang, Jeong-Hyun; Park, Seong-Hyun; Kwon, Minjae; Yoon, Chaemin; Lee, Kyungyoung; Hahm, Myong Hun; Park, Ki -Su | Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Daegyeong Healthcare & Imaging Ctr, Dept Neuroradiol, Daegu, South Korea | 57211989339; 57195615457; 7403896906; 21734563200; 59013709900; 59013710000; 59014234900; 56015548700; 55932363100 | kiss798@gmail.com; | WORLD NEUROSURGERY | WORLD NEUROSURG | 1878-8750 | 1878-8769 | 186 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2024 | 2.1 | 32.5 | 0.84 | 2025-05-07 | 1 | 1 | Brain neoplasm; Ischemia; Necrosis; Radiation; Radiosurgery | STEREOTACTIC RADIOSURGERY; RISK; RADIONECROSIS; MANAGEMENT; INFARCTION; DIAGNOSIS; VOLUME | Brain neoplasm; Ischemia; Necrosis; Radiation; Radiosurgery | Adult; Aged; Aged, 80 and over; Brain Neoplasms; Female; Humans; Male; Middle Aged; Necrosis; Radiation Injuries; Radiosurgery; Retrospective Studies; Risk Factors; steroid; adult; aged; anamnesis; anterior cerebral artery; Article; brain biopsy; brain edema; brain metastasis; brain perfusion; brain size; brain tissue; clinical assessment; clinical examination; clinical feature; controlled study; correlation analysis; craniotomy; female; gamma knife radiosurgery; human; major clinical study; male; middle cerebral artery; multivariate logistic regression analysis; parietal lobe; postoperative period; prescription; radiation dose; radiation necrosis; repeat procedure; retrospective study; stereotactic radiosurgery; symptom; treatment duration; treatment failure; tumor volume; univariate analysis; validation study; adverse event; brain tumor; etiology; middle aged; necrosis; pathology; radiation injury; radiosurgery; radiotherapy; risk factor; very elderly | English | 2024 | 2024-06 | 10.1016/j.wneu.2024.03.146 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Ceramic Aneurysm Clip with Titanium Spring | - OBJECTIVE: To design and evaluate ceramic aneurysm clips with integrated titanium springs, focusing on ergonomic application and precision in neurosurgical procedures.- METHODS: The clip design was executed with precision using Creo Parametric 3D CAD software. It comprises a zirconia body and a titanium spring for durability and consistent tension and features a four-coil hairpin titanium spring for enhanced closing force and a ball-type head for versatile maneuverability during surgery. To assess durability, closing forces were rigorously measured using a force gauge system, comparing the ceramic clip with the standard Mizuho permanent clip over 30 open-close cycles. For the assessment of magnetic resonance (MR) artifacts, both the ceramic and Yasargil clips were evaluated using a 3 Tesla (T) MRI scanner, employing specific imaging sequences.- RESULTS: The straight type ceramic clip 's initial closing force was 1.70 N, dropping to 1.22 N after 30 cycles, indicating a retention of 72% of its initial force. In MRI, the ceramic clip displayed significantly lower measurement discrepancies compared to the titanium alloy Yasargil clip, particularly in high-resolution T1-weighted images. The lowest variance was at measurement point L2, where the ceramic clip showed a 3% discrepancy. Furthermore, the ceramic clip yielded clearer images than the titanium alloy clip, particularly at the clip 's end.- CONCLUSIONS: Ceramic clips with titanium springs demonstrated satisfactory closing force and superior MRI compatibility, promising enhancements in surgical application and postoperative assessment. | Kim, Myungsoo; Park, Jaechan | Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea | 57210943611; 44661451000 | jparkmd@hotmail.com; | WORLD NEUROSURGERY | WORLD NEUROSURG | 1878-8750 | 1878-8769 | 189 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2024 | 2.1 | 32.5 | 0 | 2025-05-07 | 0 | 0 | Ceramic aneurysm clip; Cerebral aneurysm; Titanium clip; Zirconia clip | SUSCEPTIBILITY ARTIFACTS; SUBARACHNOID HEMORRHAGE; VASOSPASM; SAFETY; MRI | Ceramic aneurysm clip; Cerebral aneurysm; Titanium clip; Zirconia clip | Ceramics; Computer-Aided Design; Equipment Design; Humans; Intracranial Aneurysm; Magnetic Resonance Imaging; Neurosurgical Procedures; Surgical Instruments; Titanium; Zirconium; titanium; zirconium oxide; zirconium; zirconium oxide; Article; artifact; brain artery aneurysm; comparative study; computer aided design; controlled study; equipment design; ergonomics; follow up; human; measurement; neurosurgery; nuclear magnetic resonance imaging; T1 weighted imaging; T2 weighted imaging; ceramics; devices; diagnostic imaging; intracranial aneurysm; procedures; surgery; surgical equipment | English | 2024 | 2024-09 | 10.1016/j.wneu.2024.06.105 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Characterization of cranial growth patterns using craniometric parameters and best-fit logarithmic growth curves | Few studies have reported a complete quantitative database of cranial growth, from infancy to adulthood, as a reference through three-dimensional analysis. Our study aimed to characterize cranial growth patterns using craniometric parameters by establishing sex- and age -specific norms. In total, 1009 Korean patients (male -to -female ratio, 2:1; age range, 0-18 years) who underwent thin -slice computed tomography (CT) scans for head trauma were divided into 20 age groups, with a 6 -month interval for those under 2 years and a 1 -year interval for those over 2 years. After four reference planes [Frankfurt horizontal (FH), midsagittal, and two coronal planes passing the sella (S) and basion (B)] had been established, intracranial volume (ICV), anteroposterior diameter (APD), biparietal diameter (BPD), cranial heights (CHs), cephalic index (CI, BPD/APD), and height index (HI, CH-B/APD) were measured using Mimics software. Best -fit logarithmic curves were derived using a linear regression model. The best -fit curves for ICV (cm(3)) were y = 785.6 + 157*ln(age) for males (R-2 = 0.5752) and y = 702 + 150.5*ln(age) for females (R-2 = 0.6517). After adjustment for age, males had higher values of ICV, APD, BPD, and CHs than females (all p < 0.0001). ICV, APD, BPD, and CHs demonstrated a rapid increase during the first few months of life, reaching 90-95% of the adult size by 5-6 years of age, while CI and HI showed a continuous decline by 4%, regardless of sex. This study presented cranial growth references for more than 1000 of the Korean population aged up to 18 years. This might help to provide guidelines for diagnosis and treatment (including timing, amount, and direction) for cranial reconstruction in pediatric patients with craniosynostosis. | Jeon, Sungmi; Chung, Jee Hyeok; Baek, Seung-Hak; Yang, Il Hyung; Choi, Kang Young; Seo, Hyung Joon; Shin, Jin Yong; Kim, Byung Jun | Seoul Natl Univ, Seoul Metropolitan Govt, Boramae Med Ctr, Dept Plast & Reconstruct Surg, Seoul, South Korea; Seoul Natl Univ, Coll Med, Childrens Hosp, Div Pediat Plast Surg, Seoul, South Korea; Seoul Natl Univ, Sch Dent, Dept Orthodont, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu, South Korea; Pusan Natl Univ Hosp, Dept Plast & Reconstruct Surg, Pusan, South Korea; Jeonbuk Natl Univ Hosp, Dept Plast & Reconstruct Surg, Jeonju Si, South Korea | Baek, Seung-Hak/NOE-8444-2025 | 57216858409; 55354194600; 35090967400; 23468146600; 57203745682; 57209262219; 57189717358; 56403557700 | bjkim@snu.ac.kr; | JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY | J CRANIO MAXILL SURG | 1010-5182 | 1878-4119 | 52 | 1 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE;SURGERY | 2024 | 2.1 | 32.5 | 2.1 | 2025-04-16 | 2 | 2 | Skull; Growth; Infant; Child; Adolescent; Computed tomography | FRONTO-ORBITAL ADVANCEMENT; INTRACRANIAL VOLUME; CEPHALIC INDEX; GLOBE RELATIONSHIP; CAPACITY; CHILDREN; SKULL; CRANIOSYNOSTOSIS | Adolescent; Child; Computed tomography; Growth; Infant; Skull | Adolescent; Adult; Aged; Asian People; Cephalometry; Child; Child, Preschool; Craniosynostoses; Female; Humans; Infant; Infant, Newborn; Male; Skull; Tomography, X-Ray Computed; adolescent; adult; anatomic landmark; anterior posterior axis; anthropometric parameters; Article; biparietal distance; brachycephaly; cephalic index; child; computer assisted tomography; cranial height; craniofacial synostosis; craniometry; cross-sectional study; female; foramen magnum; groups by age; growth curve; head injury; height index; human; infant; intracranial volume; Korean (people); major clinical study; male; newborn; oxycephaly; pediatric patient; preschool child; scaphocephaly; school child; sella turcica; sex difference; skull development; aged; Asian; cephalometry; craniofacial synostosis; diagnostic imaging; procedures; skull; x-ray computed tomography | English | 2024 | 2024-01 | 10.1016/j.jcms.2023.11.013 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Clinical efficacy and performance evaluation of a bendable remote robot system for a bone tumour surgery: A pilot animal study | BackgroundTraditional open surgery for bone tumours sometimes has as a consequence an excessive removal of healthy bone tissue because of the limitations of rigid surgical instruments, increasing infection risk and recovery time.MethodsWe propose a remote robot with a 4.5-mm diameter bendable end-effector, offering four degrees of freedom for accessing the inside of the bone and performing tumour debridement. The preclinical studies evaluated the effectiveness, clinical scenario, and usability across 12 total surgeries-six phantom surgeries and six bovine bone surgeries. Evaluation criteria included skin incision size, bone window size, surgical time, removal rate, and conversion to open surgery.ResultsPreclinical studies demonstrated that the robotic approach requires significantly smaller incision size and procedure times than traditional open curettage.ConclusionThis study validated the performance of the proposed system by assessing its preclinical effectiveness and optimising surgical methods using human phantom and bovine bone tumour models. | Kim, Seungmin; Shin, Donghyun; Lee, Changhyeon; Yu, Daehee; Cho, Jongho; Bang, Hyunhee; Lee, Hyunjoo; Kim, Donghyun; Park, Ilhyung; Hong, Jaesung; Joung, Sanghyun | AIRS Inc, Robot Innovat Ctr 202, Dept Res, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Orthoped Surg, Daegu, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept Robot & Mechatron Engn, Daegu, South Korea | 59196994900; 59196782100; 59196364400; 59196782200; 59195525800; 57216785452; 58838750100; 57198637188; 35076285100; 55825553700; 14628748500 | sanghyun.joung@gmail.com; | INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY | INT J MED ROBOT COMP | 1478-5951 | 1478-596X | 20 | 4 | SCIE | SURGERY | 2024 | 2.1 | 32.5 | 0.64 | 2025-05-07 | 1 | 1 | bendable end-effector; bone tumour surgery; minimally invasive; pilot animal study | CHONDROSARCOMA | bendable end-effector; bone tumour surgery; minimally invasive; pilot animal study | Animals; Bone and Bones; Bone Neoplasms; Cattle; Equipment Design; Humans; Phantoms, Imaging; Pilot Projects; Robotic Surgical Procedures; Degrees of freedom (mechanics); Mammals; Phantoms; Robotic surgery; Surgical equipment; Tumors; agarose; gadoterate meglumine; methylene blue; Animal studies; Bendable end-effector; Bone tumor; Bone tumor surgery; Bovine bone; Minimally invasive; Open surgery; Pilot animal study; Preclinical studies; Remote robot; animal experiment; animal model; Article; bone radiography; bone tumor; bovine; chondrosarcoma; clinical effectiveness; computer assisted tomography; controlled study; conversion to open surgery; degree of freedom; minimally invasive surgery; nonhuman; nuclear magnetic resonance imaging; operation duration; orthopedic surgery; performance; pilot study; preclinical study; robot assisted surgery; rotation; skin incision; stopwatch; animal; bone; bone tumor; devices; equipment design; human; imaging phantom; procedures; surgery; End effectors | English | 2024 | 2024-08 | 10.1002/rcs.2653 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Combining Unilateral Biportal Endoscopic Surgery with Lumboperitoneal Shunt Surgery for Patients with Coexisting Normal-Pressure Hydrocephalus and Lumbar Spinal Stenosis: A Technical Note | BACKGROUND: Normal-pressure hydrocephalus (NPH) is a condition characterized by an abnormal cerebrospinal fluid homeostasis in the brain, resulting in cognitive decline, gait disturbances, and urinary incontinence. Globally, the frequency of NPH becomes has become a major clinical concern with an increase in the elderly population. A lumboperitoneal (LP) shunt surgery is one therapeutic intervention, which diverts cerebrospinal fluid from the brain to the peritoneal cavity to mitigate NPH symptoms. However, LP shunt surgery can be precluded by lumbar spine degeneration. METHODS: In the cases of comorbidity involving NPH and lumbar spine degeneration, the combination of unilateral biportal endoscopic surgery, which is a minimally invasive spinal procedure, and LP shunt surgery is a new alternative. Both spinal degeneration and NPH are concurrently addressed in this approach. RESULTS: A 70-year-old patient with NPH and severe lumbar stenosis successfully underwent the aforementioned combined surgery, with remarkable improvement in symptoms. CONCLUSIONS: While the result is promising, the efficacy of this method warrants validation by conducting larger studies. Nonetheless, combining unilateral biportal endoscopic and LP shunt surgeries could redefine treatment for elderly patients with NPH and spinal stenosis. | Park, Man-Kyu; Kang, Kyunghun; Son, Sang-Kyu; Park, Eunhee; Park, Ki-Su | Hu Hosp, Dept Neurosurg, Busan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Good Moonhwa Hosp, Dept Neurosurg, Busan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea | 55661966300; 55365592200; 57190859687; 56107216400; 55932363100 | kiss798@gmail.com; | WORLD NEUROSURGERY | WORLD NEUROSURG | 1878-8750 | 1878-8769 | 191 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2024 | 2.1 | 32.5 | 0 | 2025-05-07 | 0 | 0 | Endoscopy; Normal-pressure hydrocephalus; Shunt; Spinal stenosis | Endoscopy; Normal-pressure hydrocephalus; Shunt; Spinal stenosis | Aged; Cerebrospinal Fluid Shunts; Endoscopy; Female; Humans; Hydrocephalus, Normal Pressure; Lumbar Vertebrae; Male; Neuroendoscopy; Spinal Stenosis; analgesic agent; aged; airborne infection; Article; backache; case report; cerebrospinal fluid; clinical article; cognitive defect; computer assisted tomography; consensus; decompression surgery; durotomy; endoscopic surgery; female; gait; gait disorder; human; laminectomy; liquorrhea; lumbar puncture; lumbar spinal stenosis; Mini Mental State Examination; normotensive hydrocephalus; nuclear magnetic resonance imaging; Oswestry Disability Index; practice guideline; subcutaneous fat; surgical technique; timed up and go test; urine incontinence; walk test; cerebrospinal fluid drainage system; complication; endoscopy; lumbar vertebra; male; neuroendoscopy; normotensive hydrocephalus; procedures; surgery; vertebral canal stenosis | English | 2024 | 2024-11 | 10.1016/j.wneu.2024.08.024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Comparing outcomes of plate augmentation, nail exchange, and nail exchange with plate augmentation in the treatment of atrophic femoral shaft nonunion after intramedullary nailing: a multicenter retrospective study | IntroductionIntramedullary (IM) nailing is the treatment of choice for femoral shaft fractures, but nonunion rates have been reported to be as high as 12%. Surgical interventions for nonunion involve exchange nailing or plate augmentation. Recently, a combined treatment of exchange nailing and plate augmentation has demonstrated good results, but its comparative effectiveness remains unclear. This study aimed to compare the clinical and radiographic outcomes of three different surgical interventions for atrophic femoral shaft nonunion, and investigate the factors that affect bone healing after reoperation.Materials and methodsA retrospective study was conducted at five university hospitals involving 149 patients with aseptic atrophic nonunion after IM nailing. These patients underwent reoperation with plate augmentation, exchange nailing, or combined treatment. Clinical and radiographic outcomes were assessed and compared according to reoperation procedure. Logistic regression analysis was performed to identify factors affecting persistent nonunion after reoperation.ResultsOf the cohort, 57 patients underwent plate augmentation, 64 underwent exchange nailing, and 28 received combined treatment. There were no significant differences in patient demographics among the groups. Exchange nailing produced a significantly lower union rate than did the combined treatment (82.8% vs. 100%, p = 0.016), whereas no significant difference was observed in the union rate and time to the union between plate augmentation and the combined treatment. Combined treatment showed the longest operative time and the greatest transfusion requirements. The risk factors for persistent nonunion included age, absence of autogenous bone grafts, and use of an exchange nailing technique.ConclusionsExchange nailing as a treatment for atrophic femoral shaft nonunion after IM nailing resulted in a lower union rate. The efficacy of the combined treatment requires further study, and persistent nonunion may be influenced by age, bone grafting, and surgical techniques. A comprehensive approach targeting both biological environment and mechanical stability is crucial in the treatment of atrophic femoral shaft nonunion. | Kook, Incheol; Oh, Chang-Wug; Shon, Oog-Jin; Kim, Joon-Woo; Kim, Ji-Wan; Hwang, Kyu Tae; Park, Ki-Chul | Hanyang Univ Hosp, Dept Orthopaed Surg, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Orthopaed Surg, Daegu, South Korea; Yeungnam Univ, Med Ctr, Dept Orthopaed Surg, Daegu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Orthopaed Surg, Seoul, South Korea; Hanyang Univ, Dept Orthopaed Surg, Guri Hosp, 153,Gyeongchun Ro, Guri 11923, Gyeonggi Do, South Korea | Hwang, Kyu/R-7249-2016; Oh, Chang-Wug/AAO-4602-2021 | 58263258100; 22135834200; 8300537700; 22951329000; 55898554400; 35336689700; 57718304700 | kcpark@hanyang.ac.kr; | ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | ARCH ORTHOP TRAUM SU | 0936-8051 | 1434-3916 | 144 | 3 | SCIE | ORTHOPEDICS;SURGERY | 2024 | 2.1 | 32.5 | 1.85 | 2025-05-07 | 3 | 3 | Femoral shaft fracture; Intramedullary nailing; Atrophic nonunion; Exchange nailing; Plate augmentation; Risk factor; Persistent nonunion | RISK-FACTORS; FRACTURES; OSTEOTOMIES; INSTABILITY; MANAGEMENT | Atrophic nonunion; Exchange nailing; Femoral shaft fracture; Intramedullary nailing; Persistent nonunion; Plate augmentation; Risk factor | Bone Nails; Femoral Fractures; Fracture Fixation, Intramedullary; Fracture Healing; Fractures, Ununited; Humans; Retrospective Studies; Treatment Outcome; adult; age; Article; body mass; bone radiography; bone transplantation; clinical outcome; cohort analysis; controlled study; diabetes mellitus; female; femur shaft fracture; follow up; fracture healing; fracture nonunion; human; intramedullary nailing; length of stay; major clinical study; male; middle aged; operation duration; osteoporosis; outcome assessment; reoperation; retrospective study; risk factor; smoking; university hospital; clinical trial; femur fracture; fracture nonunion; multicenter study; treatment outcome | English | 2024 | 2024-03 | 10.1007/s00402-023-05183-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Coptis rhizome extract influence on Streptococcus pneumoniae through autolysin activation | This study investigated the antibacterial properties of Coptis rhizome, a plant traditionally used for respiratory infections, against Streptoccus pneumonia (S. pneumoniae), for which there has been minimal empirical evidence of effectiveness. The study particularly examined autolysis, indirectly associated with antibacterial resistance, when using Coptis rhizome for bacterial infections. In our methodology, Coptis rhizome was processed with ethanol and distilled water to produce four different extracts: CRET30, CRET50, CRET70, and CRDW. The antibacterial activity of these extracts were tested through Minimum Inhibitory Concentration (MIC) assays, disk diffusion tests, and time-kill assays, targeting both standard (ATCC 49619) and resistant (ATCC 70067) strains. The study also evaluated the extracts' biofilm inhibition properties and monitored the expression of the lyt gene, integral to autolysis. The results prominently showed that the CRET70 extract demonstrated remarkable antibacterial strength. It achieved an MIC of 0.125 mu g/mL against both tested S. pneumoniae strains. The disk diffusion assay recorded inhibition zones of 22.17 mm for ATCC 49619 and 17.20 mm for ATCC 70067. Impressively, CRET70 resulted in a 2-log decrease in bacterial numbers for both strains, showcasing its potent bactericidal capacity. The extract was also effective in inhibiting 77.40% of biofilm formation. Additionally, the significant overexpression of the lytA gene in the presence of CRET70 pointed to a potential mechanism of action for its antibacterial effects. The outcomes provided new perspectives on the use of Coptis rhizome in combating S. pneumoniae, especially significant in an era of escalating antibiotic resistance. | Lee, Eon-Bee; Lee, Kyubae | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Anim & Plant Quarantine Agcy, Vet Drugs & Biol Div, Gimcheon 39660, South Korea; Konyang Univ, Dept Biomed Mat, Daejeon 35365, South Korea | ; Lee, Kyubae/IXN-5539-2023; Lee, Jung Bok/HHZ-3200-2022 | 57216526135; 57211256250 | KYUBAE@konyang.ac.kr; | AMB EXPRESS | AMB EXPRESS | 2191-0855 | 14 | 1 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | 2024 | 3.7 | 32.5 | 0.55 | 2025-05-07 | 1 | 1 | Coptis rhizome; Streptoccus pneumonia; Autolysis; lytA; Antimicrobial activity; Biofilm formation | MAJOR AUTOLYSIN; IN-VITRO; BERBERINE; LYTA; INFECTIONS; MECHANISM | Antimicrobial activity; Autolysis; Biofilm formation; Coptis rhizome; lytA; Streptoccus pneumonia | autolysin; analysis of variance; antibacterial activity; Article; autolysis; bactericidal activity; bacteriolysis; biofilm inhibitory concentration; Coptis; disk diffusion; gene expression; minimum inhibitory concentration; reverse transcription polymerase chain reaction; Streptococcus pneumoniae | English | 2024 | 2024-07-04 | 10.1186/s13568-024-01736-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Current research trends on the effect of diabetes mellitus on rotator cuff tendon healing/tendinopathy | Rotator cuff tendon tears are a leading cause of shoulder pain. They are challenging to treat, and tendon-bone healing has a high failure rate despite successful surgery. Tendons connect the muscles and bones, which make them important for the body's overall mobility and stability. Metabolic diseases, including diabetes or high blood pressure, can affect the healing process after repair of a damaged tendon. With a global incidence of 9.3%, diabetes is considered as a significant risk factor for rotator cuff tendon healing because it causes structural, inflammatory, and vascular changes in the tendon. However, the mechanisms of how diabetes affects tendon healing remain unknown. Several factors have been suggested, including glycation product accumulation, adipokine dysregulation, increased levels of reactive oxygen species, apoptosis, inflammatory cytokines, imbalanced matrix-metalloproteinase-to-tissue-inhibitor ratio, and impaired angiogenesis and differentiation of the tendon sheath. Despite the effects of diabetes on tendon function and healing, few treatments are available to improve recovery in these patients. This review summarizes the current literature on the pathophysiological changes of the tendon in diabetes and hyperlipidemia. Preclinical and clinical evidence regarding the association between diabetes and tendon healing is presented. Moreover, current approaches to improve tendon healing in patients with diabetes are reviewed. | Yoon, Jong Pil; Park, Sung-Jin; Choi, Yoon Seong; Kim, Dong-Hyun; Lee, Hyun Joo; Park, Eugene Jae Jin; Chung, Seok Won | Kyungpook Natl Univ, Sch Med, Dept Orthopaed Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Carbon Hybrid Fiber Sci, Daegu, South Korea; Konkuk Univ, Sch Med, Dept Orthopaed Surg, Med Ctr, Seoul, South Korea | ; Lee, Hyun Joo/GVU-6347-2022; Park, Eugene/P-1473-2018 | 36098548400; 58527890700; 57013770300; 57198637188; 58838750100; 55371642100; 37065938600 | knuhos_sh2@naver.com; | ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | ARCH ORTHOP TRAUM SU | 0936-8051 | 1434-3916 | 144 | 6 | SCIE | ORTHOPEDICS;SURGERY | 2024 | 2.1 | 32.5 | 1.85 | 2025-05-07 | 3 | 3 | Diabetes mellitus; Rotator cuff; Tendon healing; Tendinopathy | PRO-INFLAMMATORY CYTOKINES; GLYCATION END-PRODUCTS; ACHILLES-TENDON; CROSS-LINKING; LIPID-ACCUMULATION; SKELETAL-MUSCLE; SHOULDER PAIN; COLLAGEN; ASSOCIATION; POPULATION | Diabetes mellitus; Rotator cuff; Tendinopathy; Tendon healing | adipocytokine; hemoglobin A1c; matrix metalloproteinase; metformin; reactive oxygen metabolite; AMPK signaling; angiogenesis; Article; diabetes mellitus; fracture healing; glycation; glycemic control; hospitalization; human; hyperglycemia; hyperlipidemia; hypertension; in vitro study; inflammation; metabolic disorder; non insulin dependent diabetes mellitus; risk factor; rotator cuff injury; shoulder pain; tendon sheath | English | 2024 | 2024-06 | 10.1007/s00402-024-05350-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Enhancement of thermal conducting properties in epoxy thermoset systems using an aligned liquid-crystalline mesophase | Liquid crystalline epoxy resins (LCERs) with high thermal conductivity (T/C) are an attractive solution that meet the thermal management requirements of electronic devices. The ordered microstructure derived from LCs can improve heat dissipation in the polymer network by reducing phonon scattering. Here a series of LCE systems named EB-n is successfully developed by connecting two biphenyl mesogens with several aliphatic spacers (n). The EB-n monomers with even spacers (n = 4, 6, 8) exhibit a wide nematic phase range between 160 degrees C and 230 degrees C, while EB-7 shows a weak mesophase only during heating, indicating that the spacer length controls the LC properties and molecular ordering. The curing reaction repairs the network using symmetric and asymmetric aromatic diamines capable of reacting in an aligned LC state. The resulting products exhibit high T/C with values ranging between 0.519 and 0.757 W m-1 K-1, which are about three times higher than those of conventional thermosets, and superior thermal and mechanical properties. Moreover, thermal infrared imaging demonstrates that their high T/C has an apparent effect on heat dissipation. These results suggest that the LCE system has many potential applications in the high-performance electric device industry. Liquid crystalline epoxy resins (LCERs) with high thermal conductivity (T/C) are an attractive solution that meet the thermal management requirements of electronic devices. | Trinh, Thi En; Yeo, Hyeonuk | Kyungpook Natl Univ, Dept Sci Educ, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem Educ, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Nanosci & Nanotechnol, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Pharm, 80 Daehak Ro, Daegu 41566, South Korea | ; yeo, hyeonuk/G-7890-2017; Yeo, Hyeonuk/AHE-0397-2022 | 58092720700; 55324816500 | yeo@knu.ac.kr; | MATERIALS ADVANCES | MATER ADV | 2633-5409 | 5 | 4 | ESCI | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 4.7 | 32.5 | 3.4 | 2025-05-07 | 9 | 9 | 4,4'-DIGLYCIDYLOXYBIPHENYL EPOXY; CURING KINETICS; RESINS; COMPOSITES | Thermography (imaging); Attractive solutions; Conducting properties; Electronics devices; Epoxy thermosets; High thermal conductivity; Liquid crystalline; Liquid crystalline epoxy resins; Mesophases; Ordered microstructures; Thermal; Signal receivers | English | 2024 | 2024-02-19 | 10.1039/d3ma00585b | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | High on/off ratio SiO2-based memristors for neuromorphic computing: understanding the switching mechanisms through theoretical and electrochemical aspects | Memristors have emerged as promising elements for brain-inspired computing applications, yet the understanding of their switching mechanisms, particularly in valence change memristors, remains a topic of ongoing debate. We report on the SiO2-based memristors, demonstrating a high on/off ratio (> 10(5)). Particularly, this study aims to enhance the fundamental understanding of switching behaviors and mechanisms. Our approach involved an extensive investigation using finite element analysis to provide visual insights into the conductive path evolution in these memristors over the set/reset bias cycle. Electrochemical impedance spectroscopy experimentally validated the theoretical investigations by interpreting the switching behavior through the lens of the equivalent circuit. In addition, we evaluated synaptic characteristics and incorporated them into neural networks for image recognition tasks with MNIST and Fashion MNIST datasets. Our comprehensive exploration of both the underlying principles and potential applications is of practical relevance to studies that aim to realize and implement SiO2-based memristors in neuromorphic computing. | Qin, Fei; Zhang, Yuxuan; Guo, Ziqi; Park, Tae Joon; Park, Hongsik; Kim, Chung Soo; Park, Jeongmin; Fu, Xingyu; No, Kwangsoo; Song, Han Wook; Ruan, Xiulin; Lee, Sunghwan | Purdue Univ, Sch Engn Technol, W Lafayette, IN 47907 USA; Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA; Purdue Univ, Sch Mat Engn, W Lafayette, IN 47907 USA; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Korea Inst Ceram Engn & Technol, Anal Tech Ctr, Jinju 52851, Gyeongsangnam D, South Korea; Dept Mat Sci & Engn, KAIST, Daejeon 34141, South Korea; Korea Res Inst Stand & Sci, Ctr Mass & Related Quant, Daejeon 34113, South Korea | ; Fu, Xingyu/GZM-3129-2022; Qin, Fei/JBI-9137-2023; Lee, Sunghwan/J-5424-2014 | 57445957400; 57406888900; 57931587600; 57216733230; 35366976200; 57727385200; 59632661800; 57188568553; 55398718600; 7404037634; 7102376734; 57192514024 | sunghlee@purdue.edu; | MATERIALS ADVANCES | MATER ADV | 2633-5409 | 5 | 10 | ESCI | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 4.7 | 32.5 | 1.89 | 2025-05-07 | 9 | 8 | CROSSBAR ARRAYS; TANTALUM OXIDE; FILAMENT; DEVICES; MEMORY; CONDUCTANCE; EVOLUTION; SYNAPSES | Image recognition; Sequential switching; Brain-inspired computing; Computing applications; Electrochemicals; Memristor; Neuromorphic computing; On-off ratio; SiO 2; Switching behaviors; Switching mechanism; Valence change; Memristors | English | 2024 | 2024-05-20 | 10.1039/d3ma01142a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Identification and characterization of novel ERBB4 variant associated with sporadic amyotrophic lateral sclerosis (ALS) | Amyotrophic Lateral Sclerosis (ALS) is the most common type of motor neuron disease characterized by progressive motor neuron degeneration in brain and spinal cord. Most cases are sporadic in ALS and 5-10% of cases are familiar. >50 genes are known to be associated with ALS and one of them is ERBB4. In this paper, we report the case of a 53-year-old ALS patient with progressive muscle weakness and fasciculation, but he had no cognitive decline. We performed the next generation sequencing (NGS) and in silico analysis, it predicted a highly pathogenic variant, c.2116 A > G, p.Asn706Asp (N706D) in the ERBB4 gene. The amino acid residue is highly conserved among species. ERBB4 is a member of the ERBB family of receptor tyrosine kinases. ERBB4 has multiple tyrosine phosphorylation sites, including an autophosphorylation site at tyrosine 1284 residue. Autophosphorylation of ERBB4 promotes biological activity and it associated with NRG-1/ERBB4 pathway. It is already known that tyrosine 128 phosphorylation of ERBB4 is decreased in patients who have ALS-associated ERBB4 mutations. We generated ERBB4 N706D construct using site-directed mutagenesis and checked the phosphorylation level of ERBB4 N706D in NSC-34 cells. We found that the phosphorylation of ERBB4 N706D was decreased compared to ERBB4 wild-type, indicating a loss of function mutation in ERBB4. We report a novel variant in ERBB4 gene leading to ALS through dysfunction of ERBB4. | Kwon, Younghwi; Kang, Minsung; Jeon, Yu-Mi; Lee, Shinrye; Lee, Ho-Won; Park, Jin-Sung; Kim, Hyung-Jun | Korea Brain Res Inst KBRI, Dementia Res Grp, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; DGIST, Dept Brain Sci, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Korea Brain Res Inst KBRI, Dementia Res Grp, Daegu, South Korea | 57194168806; 57719257600; 36158214700; 17342428400; 35337240700; 44061744500; 57191717907 | neurojspark@gmail.com;kijang1@kbri.re.kr; | JOURNAL OF THE NEUROLOGICAL SCIENCES | J NEUROL SCI | 0022-510X | 1878-5883 | 457 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2024 | 3.2 | 32.5 | 2.26 | 2025-05-07 | 3 | 2 | Amyotrophic lateral sclerosis; ERBB4 N706D; Next generation sequencing | ERBB4; NEURONS; NEUREGULIN-1; EXPRESSION; CLEAVAGE; MODEL; MECHANISM; DISEASE; FAMILY; BRAIN | Amyotrophic lateral sclerosis; ERBB4 N706D; Next generation sequencing | Amyotrophic Lateral Sclerosis; Amyotrophic lateral sclerosis 1; Humans; Male; Middle Aged; Mutation; Receptor, ErbB-4; Tyrosine; arginine; aspartic acid; edaravone; epidermal growth factor receptor 4; guanine nucleotide exchange C9orf72; epidermal growth factor receptor 4; ERBB4 protein, human; tyrosine; achilles reflex; adult; amino acid sequence; amino acid substitution; amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised; animal cell; Babinski reflex; back muscle; biceps brachii muscle; brachioradialis muscle; case control study; case report; clinical article; comparative study; computer model; conserved sequence; controlled study; deletion mutation; deterioration; dyspnea; electroneurography; extensor digitorum muscle; fasciculation; forced vital capacity; gastrocnemius muscle; gene expression level; gene identification; genetic association; genetic variability; high throughput sequencing; Hoffmann reflex; human; hyperreflexia; knee; Letter; limb weakness; loss of function mutation; lumbosacral region; lung function test; male; middle aged; missense mutation; motoneuron; motor neuropathy; mouse; muscle denervation; mutational analysis; neck muscle; needle electromyography; neurologic disease; nonhuman; NSC-34 cell line; paraspinal muscle; protein phosphorylation; respiratory tract intubation; site directed mutagenesis; tibialis anterior muscle; vastus lateralis muscle; wild type; amyotrophic lateral sclerosis; genetics; metabolism; mutation | English | 2024 | 2024-02-15 | 10.1016/j.jns.2024.122885 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Induced membrane technique with plate fixation has a lower complication rate than bone transport over a plate for segmental tibial defects larger than 5 cm | IntroductionThe treatment of segmental tibial bone defects remains a surgical challenge. While Bone Transport (BT) and Induced Membrane Technique (IMT) are effective strategies for regenerating bone, there are few comparative studies between them. This investigation undertakes a comparative analysis of BT and IMT for large segmental tibial defects stabilised through plate fixation.Materials and methodsPatients with segmental tibial defects exceeding 5 cm were prospectively enrolled from 2008 to 2021 in a single institution, with a minimum follow-up duration of two years. All patients underwent either BT or IMT with plate fixation of the tibia. Procedural success, primary union as well as bone and functional outcome scores were compared. Complications, including non-unions, joint contractures and deep infections requiring surgical intervention, were also compared.Results41 patients were recruited in total. 28 patients underwent Bone Transport Over a Plate (BTOP), while 13 patients underwent IMT with Plate fixation (IMTP). The procedural success rate trended higher in IMTP compared to BTOP (100% vs. 85.7%). The primary union rate also trended higher in IMTP compared to BTOP (92.3% vs. 79.2%). BTOP and IMTP achieved similar rates of satisfactory bone outcome scores (78.6% vs. 84.6%) and functional outcome scores (75% vs. 76.5%). There was no statistical difference between procedural success, primary union, bone and functional outcome scores. The complication rate in BTOP was 78.6% (22 of 28), including five docking site or regenerate non-unions, eight deep infections and nine joint contractures. IMTP had a 38.5% (5 of 13) complication rate, including one non-union, two deep infections and two joint contractures. The complication rate was 2.04 times higher in BTOP compared to IMTP (p = 0.0117).ConclusionsBTOP and IMTP are both equally effective techniques for regenerating bone in large tibial bone defects. However, IMTP may be a safer procedure than BTOP, with a lower probability of requiring additional procedures to address complications. | Seng, Daniel W. R.; Oh, Chang-Wug; Kim, Joon-Woo; Park, Kyeong-Hyeon; Oh, Jong-Keon; Yoon, Yong-Cheol | Natl Hlth Grp, Woodlands Hlth, Dept Orthopaed Surg, Singapore, Singapore; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthopaed Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Yonsei Univ, Severance Childrens Hosp, Coll Med, Dept Orthopaed Surg, Seoul 03722, South Korea; Korea Univ, Guro Hosp, Sch Med, Dept Orthopaed Surg, Seoul 10408, South Korea; Gachon Univ, Coll Med, Trauma Ctr, Orthoped Trauma Div, Incheon 21565, South Korea | Oh, Chang-Wug/AAO-4602-2021; Yong-Cheol, Yoon/HPD-8077-2023; Park, KyeongHyeon/KEH-4919-2024 | 59828957800; 22135834200; 22951329000; 56969984400; 7402155046; 37082544400 | cwoh@knu.ac.kr; | ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | ARCH ORTHOP TRAUM SU | 0936-8051 | 1434-3916 | 144 | 5 | SCIE | ORTHOPEDICS;SURGERY | 2024 | 2.1 | 32.5 | 0 | 2025-05-07 | 0 | 0 | Induced membrane; Bone transport; Bone loss | MASQUELET TECHNIQUE; CHRONIC OSTEOMYELITIS; EXTERNAL FIXATOR; RECONSTRUCTION; MANAGEMENT | Bone loss; Bone transport; Induced membrane | Adult; Aged; Bone Plates; Bone Regeneration; Bone Transplantation; Female; Fracture Fixation, Internal; Humans; Male; Middle Aged; Postoperative Complications; Prospective Studies; Tibia; Tibial Fractures; C reactive protein; adult; aged; Article; bone graft; bone regeneration; bone remodeling; bone transplantation; clinical article; clinical outcome; debridement; demographics; female; follow up; human; induced membrane technique; joint contracture; leukocyte count; male; molecular docking; osteolysis; plate fixation; segmental tibial defect; surgical technique; tibia; tibia fracture; bone transplantation; comparative study; devices; middle aged; osteosynthesis; postoperative complication; procedures; prospective study | English | 2024 | 2024-05 | 10.1007/s00402-024-05262-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Investigation on photoexcited state dynamics in Cs1ₓFAₓPbI₃ perovskite quantum dots: A nanosecond transient absorption spectroscopy analysis | This study provides a perceptive analysis of the excited -state properties of Cs1ₓFAₓPbI₃ perovskite quantum dots (PQDs), which were synthesized using a facile and scalable low -temperature, open-air method. In the obtained transient absorption spectra of all examined PQD films, a noticeable photo -induced absorption (PIA) signal at 500 nm, coupled with a ground -state bleaching (GSB) signal ranging from 685 to 745 nm, is observed. The progressive elevation of formamidinium (FA) content within the perovskite quantum dots (PQDs) resulted in a faster non -radiative recombination, pointing towards a decreased density of trap states. This phenomenon finds validation in the observed attenuation of the PIA signal. Simultaneously, this led to a slower direct recombination, a fact substantiated by the observed strengthening of the GSB signal. Notably, the observed carrier lifetime increases markedly until the FA content reached 0.75, extending to over 2 mu s. However, higher FA contents are found to have a negative impact on the carrier lifetime and, consequently, the device performance. Furthermore, the observed red -shifted GSB peak in PQDs is ascribed to band -gap reduction in the PQDs, resulting from an increased FA content. These findings provide insights into the intrinsic photo -physics of mixed -cation halide PQDs, with direct implications for applications in optoelectronics. | Fattahimoghaddam, Hossein; Ham, Gayoung; Lee, Dongwoon; Yang, Han Sol; Kim, In Ho; Jeong, Yong Jin; Jang, Jaeyoung; Cha, Hyojung; An, Tae Kyu | Korea Natl Univ Transportat, Dept Polymer Sci & Engn, Chungju 27469, South Korea; Korea Natl Univ Transportat, Chem Ind Inst, Chungju 27469, South Korea; Kyungpook Natl Univ, Dept Energy Convergence & Climate Change, Daegu 41566, South Korea; Hanyang Univ, Dept Energy Engn, Seoul 04763, South Korea; Korea Natl Univ Transportat, Dept Mat Sci & Engn, Chungju 27469, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea | An, Tae/AAK-5174-2020; Kim, Jin Il/JWP-3629-2024; Fattahimoghaddam, Hossein/ABA-6382-2020 | 57218541307; 58506766600; 57980057000; 57204910295; 58576577100; 56033346800; 55730015300; 35885242200; 35190164200 | jyjang15@hanyang.ac.kr;hcha@knu.ac.kr;taekyu1985@ut.ac.kr;jyjang15@hanyang.ac.k; | MATERIALS CHEMISTRY AND PHYSICS | MATER CHEM PHYS | 0254-0584 | 1879-3312 | 316 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 4.7 | 32.5 | 0.33 | 2025-05-07 | 2 | 2 | Perovskite quantum dots; Mixed cation quantum dots; Transient absorption spectroscopy; Charge transfer | HALIDE PEROVSKITES; NANOCRYSTALS; STABILIZATION; STABILITY; ELECTRON; CSPBX3; BR; CL | Charge transfer; Mixed cation quantum dots; Perovskite quantum dots; Transient absorption spectroscopy | Blue shift; Carrier lifetime; Charge transfer; Energy gap; Excited states; Ground state; Nanocrystals; Perovskite; Positive ions; Red Shift; Semiconductor quantum dots; Temperature; Absorption signals; Ground state bleaching; Mixed cation quantum dot; Mixed cations; Nanosecond transient absorption; Perovskite quantum dot; Photoexcited state; Photoinduced absorption; State dynamics; Transient absorption spectroscopies; Transient absorption spectroscopy | English | 2024 | 2024-04-01 | 10.1016/j.matchemphys.2024.128995 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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