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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Preparation of Eggshell-Type Ru/Al2O3 Catalysts for Hydrogen Production Using Steam-Methane Reforming on PEMFC | Ru-based eggshell-type catalysts, in which Ru is located at the outer region of the pellet, were prepared by the impregnation method, using spherically shaped gamma-Al2O3 pellets for steam-methane reforming (SMR). Ru was only supported on the external region of the pellet because of the strong interaction between its precursor and the alumina pellet. The Ru precursor penetrated the inside of the pellet by adding nitric acid to the impregnation solution. The distribution and thickness of the Ru layer in the catalyst can be controlled using the HNO3/Ru molar ratio and contact time at the impregnation step. Among the catalysts, the graded eggshell-type catalyst showed the highest activity and long-term stability in the SMR reaction. In addition, in the daily startup and shutdown (DSS) operation, similar to the hydrogen production environment for domestic polymer electrolyte membrane fuel cells (PEMFC), the graded eggshell-type catalyst showed high activity and stability after multiple cycles. Based on the experimental studies, it was confirmed that Ru-based catalysts are suitable for steam-methane reforming for PEMFC. | Lee, Jong-Heon; Jo, Seongbin; Kim, Tae-Young; Woo, Jin-Hyeok; Lee, Yeji; Kim, Min-Seok; Park, Hye-Ok; Lee, Soo-Chool; Kim, Jae-Chang | Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea; Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA; Kyungpook Natl Univ, Res Inst Adv Energy Technol, Daegu 41566, South Korea; S Fuelcell, Suwon 16648, South Korea; Sudokwon Landfill Site Management Corp, Incheon 22688, South Korea | ; Kim, Yu/L-8480-2017; Jo, SeongBin/MFJ-9000-2025 | 57218697910; 57190754848; 57208461628; 57215492471; 57224079250; 57200444983; 57226778831; 8524020100; 55382762400 | rnswma123@knu.ac.kr;sjo016@ucr.edu;tyoung0218@knu.ac.kr;wjh8865@knmac.kr;yejeelee@knu.ac.kr;minseok.kim@s-fuelcell.com;hioki07@slc.or.kr;soochool@knu.ac.kr;kjchang@knmac.kr;kjchang@knu.ac.kr; | CATALYSTS | CATALYSTS | 2073-4344 | 11 | 8 | SCIE | CHEMISTRY, PHYSICAL | 2021 | 4.501 | 42.7 | 0.19 | 2025-07-30 | 3 | 5 | eggshell-type catalyst; fuel cell; steam-methane reforming; daily startup and shutdown operation | ALUMINA; CH4; SILICA; RH | Daily startup and shutdown operation; Eggshell-type catalyst; Fuel cell; Steam-methane reforming | English | 2021 | 2021-08 | 10.3390/catal11080951 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Simplified Classification of Tear Film Break-Up Patterns and Their Clinicopathological Correlations in Patients With Dry Eye Disease | Purpose: To analyze the pathophysiological differences between patients with dry eye disease (DED) having different tear film break-up patterns (TBUPs). Methods: This investigative analysis involved 91 eyes of 91 patients with DED who were divided into two groups: those with "dot" break-up pattern (group I) and those with "random" break-up pattern (group II). Clinical severity was evaluated using the Ocular Surface Disease Index (OSDI), Oxford stain score system (OSS) score, and tear film break-up time (TF-BUT). Eighteen patients in group I and 17 patients in group II were selected for sampling of tears and the conjunctiva, and the concentrations of inflammatory cytokines and mucin in the tears and conjunctival tissue were measured. Results: Thirty-seven patients were classified as group I and 54 patients as group II. Patients in group I had a statistically lower TF-BUT and a higher OSS score than those in group II, whereas the OSDI was not statistically different between the groups. The concentrations of interleukin (IL)-6 and IL-8 were statistically higher in group I than those in group II. Impression cytology showed that the expression of IL-1 beta and IL-8 was higher in group I, whereas that of other genes was not statistically different. Conclusions: We were able to clearly classify patients with DED with different TBUPs into two groups, and each group had different clinical and pathophysiological characteristics. In patients with the dot break-up pattern, the disease was strongly associated with ocular surface inflammation, as opposed to that in patients without this pattern. | Eom, Hee Dong; Jung, Jae Uk; Lee, Kyoung-Pil; Kim, Jeongho; Yoon, Dong Hee; Kim, Myung Jun; Son, Byung Jae; Kim, Hong Kyun | Kyungpook Natl Univ Hosp, Dept Ophthalmol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Inst, Daegu, South Korea; Metro Eye Ctr, Daegu, South Korea; Kyungpook Natl Univ, Dept Ophthalmol, Sch Med, 130 Dongdeok Ro, Daegu 41944, South Korea | Jung, Jiung/F-5829-2017 | 57202378270; 57204707632; 57204505517; 57219385573; 57201671265; 57201675200; 58826291500; 57218260940 | okeye@knu.ac.kr; | EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE | EYE CONTACT LENS | 1542-2321 | 1542-233X | 47 | 1 | SCIE | OPHTHALMOLOGY | 2021 | 3.152 | 42.7 | 0.64 | 2025-07-30 | 4 | 4 | Dry eye disease; Tear film break-up; Ocular surface inflammation; Tear film instability | DIAGNOSTIC-TESTS | Dry eye disease; Ocular surface inflammation; Tear film break-up; Tear film instability | Conjunctiva; Cytokines; Dry Eye Syndromes; Humans; Inflammation; Tears; cytokine; conjunctiva; dry eye; human; inflammation; lacrimal fluid | English | 2021 | 2021-01 | 10.1097/icl.0000000000000706 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Clinical characteristics and prognostic factors of acquired haemophilia A in Korea | Introduction Acquired haemophilia A (AHA) treatment involves the haemostatic treatment for acute haemorrhage and immunosuppressive therapy (IST) to eradicate FVIII inhibitory antibodies. Aim We assessed the clinical features of AHA and analysed treatment outcomes in Korea. We further identified prognostic factors affecting treatment outcomes. Methods Medical records of 55 patients with AHA from 18 institutions were reviewed retrospectively. Logistic and Cox regression analyses were performed to elucidate clinical factors affecting the achievement of complete remission (CR). The primary endpoint was time to CR after IST, and secondary endpoints were time to haemostasis, the achievement of CR, and overall survival (OS). Results Among the 55 patients, 50 (91%) had bleeding symptoms. Bleeding was severe in 74% of patients. Thirty-six (72%) patients received haemostatic therapy. Of the 42 patients who received IST, 23 (52%) received steroid alone, with a 52% response rate, and 10 (25%) received a combination of steroid and cyclophosphamide, with an 83% response rate. Five (16%) patients relapsed after a median duration of 220 days. There were eight deaths. In the Cox regression analysis, the FVIII inhibitor titre >= 20 BU/mL was the only significant prognostic factor affecting time to CR and haemostasis. No significant difference was observed in OS based on the inhibitor titre. Conclusion The present study demonstrated the demographic data of AHA in Korea and showed that FVIII inhibitory antibody titre was a predictor of time to achieve CR after IST. | Hyun, Shin Young; Shin, Ho-Jin; Yoon, Sung-Soo; Moon, Joon Ho; Han, Jae Joon; Yang, Deok-Hwan; Lee, Won Sik; Bang, Soo-Mee; Yhim, Ho-Young; Kim, Sung-Hyun; Oh, Doyeun; Do, Young Rok; Park, Yong; Choi, Chul Won; Lee, Je-Hwan; Jang, Ji Eun; Kim, Soo-Jeong; Hwang, Doh Yu; Kim, Jin Seok | Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Pusan Natl Univ, Div Hematol Oncol, Dept Internal Med, Sch Med,Pusan Natl Univ Hosp, Busan, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul Natl Univ Hosp, Seoul, South Korea; Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Kyungpook Natl Univ, Daegu, South Korea; Kyung Hee Univ, Dept Hematol Oncol, Coll Med, Seoul, South Korea; Chonnam Natl Univ, Med Sch, Hwasun Hosp, Dept Hematooncol, Jeollanam Do, South Korea; Inje Univ, Dept Internal Med, Busan Paik Hosp, Busan, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Jeonbuk Natl Univ, Dept Internal Med, Med Sch, Jeonju, South Korea; Dong A Univ, Dept Internal Med, Coll Med, Busan, South Korea; CHA Univ, Dept Internal Med, Sch Med, Seongnam, South Korea; Keimyung Univ, Sch Med, Div Hematol Oncol, Dongsan Hosp, Daegu, South Korea; Korea Univ, Dept Internal Med, Div Hematol Oncol, Anam Hosp, Seoul, South Korea; Korea Univ, Dept Internal Med, Div Hematol Oncol, Guro Hosp, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Hematol, Coll Med, Seoul, South Korea; Yonsei Univ, Div Hematol, Severance Hosp, Coll Med,Dept Internal Med, Seoul, South Korea | , 한재준(의과대학 의학과)/AAT-6350-2020; Kim, Soo-Jeong/F-1024-2017; Lee, Jae-Hyun/ABE-3803-2020; KIM, JIN/I-6927-2019 | 36968571000; 16239868400; 7404036304; 56568642700; 57203488910; 8701758000; 55556573100; 7102038069; 35785270600; 56547959500; 7203001784; 8960168300; 7405373234; 13907063000; 16637544900; 55449370900; 56596895200; 54684119900; 55032033600 | hemakim@yuhs.ac; | HAEMOPHILIA | HAEMOPHILIA | 1351-8216 | 1365-2516 | 27 | 5 | SCIE | HEMATOLOGY | 2021 | 4.268 | 43.0 | 0.38 | 2025-07-30 | 8 | 7 | acquired; autoantibodies; factor 8 deficiency; haemorrhage; haemostasis; immunosuppressive agents | SURVEILLANCE; THERAPY | acquired; autoantibodies; factor 8 deficiency; haemorrhage; haemostasis; immunosuppressive agents | Factor VIII; Hemophilia A; Humans; Immunosuppressive Agents; Prognosis; Republic of Korea; Retrospective Studies; Treatment Outcome; blood clotting factor 8 concentrate; blood clotting factor 8 inhibitor; cyclophosphamide; steroid; blood clotting factor 8; immunosuppressive agent; acquired hemolytic anemia; acquired hemophilia A; acquired hemophilia A; adolescent; adult; aged; antibody titer; Article; bleeding; clinical feature; clinical outcome; controlled study; disease assessment; disease severity; female; hemophilia A; hemostasis; human; immunosuppressive treatment; Korea; major clinical study; male; medical record; overall survival; prognosis; relapse; remission; retrospective study; symptom; complication; epidemiology; prognosis; South Korea; treatment outcome | English | 2021 | 2021-09 | 10.1111/hae.14370 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Diagnostic values of F-18 FDG PET or PET/CT, CT, and US for Preoperative Lymph Node Staging in Thyroid Cancer: A Network Meta-Analysis | Objective This study compared the diagnostic performance of three different imaging modalities for preoperative lymph node (LN) staging in thyroid cancer patients, using a network meta-analysis (NMA). Methods PubMed and Embase were searched to identify studies evaluating the performance of F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET or PET/CT), computed tomography (CT), and ultrasonography (US) for preoperative LN staging in thyroid cancer patients. The NMA included both patient- and lesion-based analyses. The surface under the cumulative ranking curve (SUCRA) values was used to decide on the most effective diagnostic method. Results A total of 3,571 patients from 19 direct comparison studies using three different imaging modalities for preoperative LN staging in thyroid cancer patients were included. US showed the highest SUCRA values for positive predictive values (PPV), negative predictive values (NPV), and accuracy in detection of all cervical LN metastasis. F-18 FDG PET or PET/CT and US showed the highest SUCRA values for PPV and sensitivity, respectively, for central LN, and the highest SUCRA value of specificity and sensitivity, respectively, for lateral LN. Conclusion The results from this NMA indicate that F-18 FDG PET or PET/CT, CT, and US have complementary diagnostic roles for preoperative staging in thyroid cancer patients. Advances in knowledge Using NMA, we comprehensively compared the different diagnostic values and limitations of F-18 FDG PET or PET/CT, CT, and US for the preoperative LN staging in thyroid cancer patients. | Kim, Keunyoung; Shim, Sung-Ryul; Lee, Sang-Woo; Kim, Seong-Jang | Pusan Natl Univ Hosp, Dept Nucl Med, Busan, South Korea; Korea Univ, Sch Med, Dept Prevent Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Pusan Natl Univ, Dept Nucl Med, Yangsan Hosp, Yangsan, South Korea; Pusan Natl Univ, BioMed Res Inst Convergence Biomed Sci & Technol, Yangsan Hosp, Yangsan 50612, South Korea; Pusan Natl Univ, Coll Med, Dept Nucl Med, Yangsan 50612, South Korea | shim, sungryul/D-3792-2016; Kim, Yun Hak/ABF-3331-2021; lee, sangwoo/KUD-1906-2024; Kim, Dong/I-7600-2015 | 36523010700; 55072270800; 57196249819; 35810391700 | growthkim@daum.net; | BRITISH JOURNAL OF RADIOLOGY | BRIT J RADIOL | 0007-1285 | 1748-880X | 94 | 1120 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2021 | 3.629 | 43.0 | 0.9 | 2025-07-30 | 16 | 16 | EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY; SURGICAL-MANAGEMENT; NECK DISSECTION; PAPILLARY; ULTRASONOGRAPHY; METASTASIS; ULTRASOUND; CARCINOMA; PREDICTION; THERAPY | Fluorodeoxyglucose F18; Humans; Lymph Nodes; Lymphatic Metastasis; Neck; Neoplasm Staging; Network Meta-Analysis; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Preoperative Care; Thyroid Neoplasms; Tomography, X-Ray Computed; Ultrasonography; fluorodeoxyglucose f 18; adolescent; adult; aged; cancer staging; cancer surgery; cervical lymph node metastasis; clinical effectiveness; computer assisted tomography; diagnostic accuracy; diagnostic value; echography; female; human; intermethod comparison; male; meta analysis; middle aged; network meta-analysis; poorly differentiated thyroid cancer; positron emission tomography; positron emission tomography-computed tomography; predictive value; preoperative evaluation; Review; sensitivity and specificity; statistical parameters; surface under the cumulative ranking curve; systematic review; thyroid cancer; thyroid follicular carcinoma; thyroid medullary carcinoma; thyroid papillary carcinoma; cancer staging; diagnostic imaging; echography; lymph node; lymph node metastasis; neck; pathology; positron emission tomography; positron emission tomography-computed tomography; preoperative care; procedures; thyroid tumor; x-ray computed tomography | English | 2021 | 2021 | 10.1259/bjr.20201076 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Patients' and parents' satisfaction with, and preference for, haemophilia A treatments: a cross-sectional, multicentre, observational study | Introduction Reports on patients' satisfaction and preferred characteristics for treatments would be worthwhile when choosing an optimal treatment reflecting patients' perspectives. Aim To identify the characteristics and treatment patterns of patients with haemophilia A, or their caregivers, in Korea and explore patient preferences and satisfaction with their treatment. Methods This cross-sectional, multicentre, observational study was conducted from April 2018 to September 2019 at six nationwide hospitals and three Korea Hemophilia Foundation clinics. Patients aged >= 16 years, or legal caregivers of paediatric patients, who had used factor VIII (FVIII) concentrates for >= 1 month were enrolled. Satisfaction with treatment was measured using the Treatment Satisfaction Questionnaire for Medication (TSQM); preference was evaluated using discrete choice experiment (DCE), with 10 series of two hypothetical treatment options created from D-efficient block design, which varied across five attributes. Results Overall, 505 patients (mean age 31 years) were enrolled in the study. Patients had received FVIII concentrate for an average of 102.9 months (prophylaxis: 53.5%; on-demand: 22.2%). Mean TSQM scores were 64.6 (effectiveness domain), 97.9 (side effects), 57.1 (convenience) and 66.8 (global satisfaction). The number of vials per injection, and the frequency of drug administration, was significantly associated with treatment satisfaction. According to DCE, simpler treatment options were preferred by patients/caregivers. Conclusion The lowest satisfaction levels were shown in the treatment convenience domain. Patients/parents preferred simpler and easier treatment characteristics. In an attempt to enhance the overall satisfaction of patients and caregivers with treatment, consideration of more convenient characteristics is required in future decisions regarding treatment selection. | Park, Young Shil; Hwang, Tai Ju; Cho, Goon Jae; Kim, Soon Ki; Park, Sang Kyu; Kim, Ji Yoon; Baek, Hee Jo; Kim, Young-Joo; Lee, Ho-Jin; Shin, Ji-Soo; Nam, Chung-Mo; Sun, Jiyu; Yoo, Ki Young | Kyung Hee Univ Hosp Gangdong, Dept Pediat, Seoul, South Korea; Korea Hemophilia Fdn Gwangju Clin, Gwang Ju, South Korea; Korea Hemophilia Fdn Busan Clin, Busan, South Korea; Inha Univ Hosp, Dept Pediat, Incheon, South Korea; Ulsan Univ Hosp, Dept Pediat, Ulsan, South Korea; Kyungpook Natl Univ Hosp, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Dept Pediat Hematol & Oncol, Chilgok Hosp, Daegu, South Korea; Chonnam Natl Univ, Med Sch, Hwasun Hosp, Dept Pediat, Gwangju, South Korea; Pfizer Pharmaceut Korea Ltd, Med Dept, Seoul, South Korea; Yonsei Univ, Dept Biostat & Comp, Seoul, South Korea; Korea Hemophilia Fdn Clin KHF Clin, Seoul, South Korea | ; Kim, Woo/D-2733-2015 | 55494467600; 7202849005; 57224577065; 55190025100; 57209835309; 57205408095; 36724802200; 57207443255; 57224585232; 57224565584; 25960308100; 57208754963; 35209416500 | gowho@hotmail.com; | HAEMOPHILIA | HAEMOPHILIA | 1351-8216 | 1365-2516 | 27 | 4 | SCIE | HEMATOLOGY | 2021 | 4.268 | 43.0 | 0.91 | 2025-07-30 | 11 | 13 | factor VIII; haemophilia; preference; satisfaction; treatment | FACTOR-VIII DELIVERY; PROPHYLAXIS; DISEASE | factor VIII; haemophilia; preference; satisfaction; treatment | Child; Cross-Sectional Studies; Hemophilia A; Humans; Infant, Newborn; Parents; Patient Preference; Patient Satisfaction; Personal Satisfaction; blood clotting factor 8; adult; arthropathy; Article; bleeding; body mass; cohort analysis; disease duration; disease severity; female; hemophilia A; human; information processing; major clinical study; male; multicenter study; observational study; patient satisfaction; prophylaxis; questionnaire; treatment satisfaction questionnaire; treatment satisfaction questionnaire for medication; child; child parent relation; clinical trial; cross-sectional study; hemophilia A; newborn; patient preference; patient satisfaction; satisfaction | English | 2021 | 2021-07 | 10.1111/hae.14304 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Traceable quantitative analysis of Ag x Cu1-x alloy films by ID ICP-MS, RBS and MEIS | The measurement traceability of Rutherford backscattering spectroscopy (RBS), medium energy ion scattering spectroscopy (MEIS) and isotope dilution inductively coupled plasma mass spectrometry (ID ICP-MS) was compared for the quantitative analysis of alloy thin films. A set of thin Ag x Cu1-x alloy films were selected as a model alloy system for the quantitative analysis of MEIS and ID ICP-MS. Two sets of five Ag x Cu1-x alloy films with different mole fractions were grown on Si (100) wafers by ion beam sputter deposition. The mole fractions of thick Ag x Cu1-x alloy films (100 nm) measured by RBS and ID ICP-MS showed a great agreement within 0.4% difference. The mole fractions of thin Ag x Cu1-x alloy films (10 nm) measured with MEIS and ID ICP-MS also showed a small difference of about 1.0%. As a result, ID ICP-MS, RBS and MEIS can be used to certify the mole fractions of thin alloy reference films. ID ICP-MS is an absolute method for the mole fraction analysis of thin Ag x Cu1-x alloy films. Although the contribution of sample homogeneity was included, the uncertainties of ID ICP-MS results were much smaller than those of RBS and MEIS. | Kim, Tae Gun; Heo, Sung Woo; Min, Won Ja; Han, Tae-Hun; Yim, Yong-Hyeon; Yu, Hyunung; Kim, Kyung Joong | KRISS, Surface Anal Team, 267 Gajeong Ro, Daejeon 34113, South Korea; KRISS, Inorgan Metrol Grp, 267 Gajeong Ro, Daejeon 34113, South Korea; HB Solut, 77-26 Yeonamyulgeum Ro, Asan, Chungcheongnam, South Korea; Kyungpook Natl Univ, Dept Chem, 80 Daehak Ro, Daegu 41566, South Korea | Kim, Jeong/B-6215-2012; Heo, Sung Woo/A-1366-2012 | 57193087145; 57208293117; 56009918500; 57325797400; 57203216226; 55840187400; 25950161900 | kjkim@kriss.re.kr; | METROLOGIA | METROLOGIA | 0026-1394 | 1681-7575 | 58 | 6 | SCIE | INSTRUMENTS & INSTRUMENTATION;PHYSICS, APPLIED | 2021 | 2.748 | 43.0 | 0.09 | 2025-07-30 | 1 | 1 | traceability; quantitative analysis; ID ICP-MS; MEIS; RBS | MASS-SPECTROMETRY; SURFACE-ANALYSIS; THIN-FILMS; SIMS; ACCURATE; MULTILAYER; SCATTERING; XPS | ID ICP-MS; MEIS; quantitative analysis; RBS; traceability | Chemical analysis; Inductively coupled plasma mass spectrometry; Ion beams; Mass spectrometers; Rutherford backscattering spectroscopy; Silicon wafers; Thin films; Alloy film; Alloy system; Alloy thin films; Isotope dilution inductively coupled plasma mass spectrometry; Measurement traceability; Medium energy ion scattering spectroscopies; Model alloys; Molefraction; Si(1 0 0); Traceability; Metallic films | English | 2021 | 2021-12 | 10.1088/1681-7575/ac28e2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A comprehensive phylogeography of the widespread pond snail genus Radix revealed restricted colonization due to niche conservatism | To clarify the effect of niche conservatism on evolutionary history, we focused on freshwater snails, which have different ecological and phylogenetic properties from previously tested taxa. We conducted a phylogenetic analysis using 750 lymnaeid individuals from 357 sites of eleven Radix species. Then, we estimated the ancestral distribution using the geographic coordinates and colonization routes. In addition, a statistical test of the colonization distances in the latitudinal and longitudinal directions was performed. We also conducted ecological niche modeling for two widely distributed species using climatic data. Ancestral geographic reconstruction estimated the origin of the genus to be around the Indian subcontinental region and showed that latitudinal immigration distances were shorter than longitudinal immigration distances in the diversification process. Ecological niche models suggested that the current distribution was restricted by climate, with annual mean temperature and precipitation of the driest month as particularly strong factors. Niche conservatism to the climate can affect the diversification of freshwater snails. | Saito, Takumi; Hirano, Takahiro; Ye, Bin; Prozorova, Larisa; Shovon, Mohammad Shariar; Do, Tu Van; Kimura, Kazuki; Surenkhorloo, Purevdorj; Kameda, Yuichi; Morii, Yuta; Fukuda, Hiroshi; Chiba, Satoshi | Tohoku Univ, Grad Sch Life Sci, Sendai, Miyagi, Japan; Toho Univ, Dept Biol, Fac Sci, Funabashi, Chiba, Japan; Tohoku Univ, Ctr Northeast Asian Studies, Sendai, Miyagi, Japan; Russian Acad Sci, Far Eastern Branch, Fed Sci Ctr, East Asia Terr Biodivers, Vladivostok, Russia; Rajshahi Univ, Dept Biochem & Mol Biol, Rajshahi, Bangladesh; Vietnam Acad Sci & Technol, Inst Ecol & Biol Resources, Hanoi, Vietnam; Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, Hanoi, Vietnam; Kyungpook Natl Univ, Res Inst Ulleung & Dok Isl, Dept Biol, Daegu, South Korea; Mongolian Benthol Soc MOBS, Ulaanbaatar, Mongolia; Natl Museum Nat & Sci, Mol Biodivers Res, Tsukuba, Ibaraki, Japan; Kyoto Univ, Grad Sch Sci, Dept Zool, Lab Anim Ecol, Kyoto, Japan; Kyoto Univ, Hakubi Ctr, Kyoto, Japan; Okayama Univ, Conservat Aquat Biodivers, Fac Agr, Okayama, Japan | Ye, Bin/JCO-3018-2023; Morii, Yuta/IUQ-0099-2023; Prozorova, Larisa/O-1596-2018; Kimura, Kazuki/AAF-4137-2020 | 56978468500; 55882719800; 57208341741; 57189893548; 54401623200; 57201353600; 55464858400; 13607294400; 22234387100; 56521146200; 35408388700; 55697248000 | saito.zef@gmail.com; | ECOLOGY AND EVOLUTION | ECOL EVOL | 2045-7758 | 11 | 24 | SCIE | ECOLOGY;EVOLUTIONARY BIOLOGY | 2021 | 3.167 | 43.1 | 0.93 | 2025-07-30 | 10 | 9 | dispersal; freshwater snail; latitudinal diversity gradient; Lymnaeidae; Mollusca; passive disperser; tropical conservatism hypothesis | LATITUDINAL DIVERSITY GRADIENT; SPP. GASTROPODA LYMNAEIDAE; SPECIES RICHNESS GRADIENT; FRESH-WATER GASTROPOD; TROPICAL CONSERVATISM; BIODIVERSITY GRADIENT; CLIMATE; DIVERSIFICATION; CONSEQUENCES; PULMONATA | English | 2021 | 2021-12 | 10.1002/ece3.8434 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A novel REEP1 splicing mutation with broad clinical variability in a family with hereditary spastic paraplegia | Hereditary spastic paraplegia (HSP) is a heterogeneous group of genetic disorders characterized by lower-limb spastic paralysis. We report on a family with three generations of autosomal dominant inheritance of HSP caused by a novel heterozygous splice-site mutation (c.303 + 2 T > C) in REEP1 that was confirmed by RFLP analysis. Carriers of the mutation, including one asymptomatic individual, showed a mild HSP phenotype with a wide range of intrafamilial variation. All symptomatic carriers had ankle contractures in addition to other classical clinical symptoms of HSP. Clinicians should suspect REEP1-related HSP in patients who show ankle contractures with other symptoms of HSP and should consider that these patients have asymptomatic carriers within their family. | Park, Seong-Yong; Park, Jin-Mo; Lee, Byeonghyeon; Kim, Un-Kyung; Park, Jin-Sung | Kyungpook Natl Univ, Dept Biol, Coll Nat Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioResearch Grp, Daegu, South Korea; Dongguk Univ, Gyeongju Hosp, Dept Neurol, Coll Med, Gyeongju, South Korea; Kyungpook Natl Univ, Dept Neurol, Sch Med, Chilgok Hosp, Daegu, South Korea | Park, Seong Yong/IZQ-1385-2023 | 57215060790; 55569003000; 56384026400; 7102248968; 44061744500 | kimuk@knu.ac.kr;neurojspark@gmail.com; | GENE | GENE | 0378-1119 | 1879-0038 | 765 | SCIE | GENETICS & HEREDITY | 2021 | 3.913 | 43.1 | 0.06 | 2025-07-30 | 0 | 1 | Hereditary spastic paraplegia; REEP1; Novel splicing mutation; Asymptomatic; Whole-exome sequencing | AUTOSOMAL-DOMINANT; FEATURES; SPECTRUM; VARIANT | Asymptomatic; Hereditary spastic paraplegia; Novel splicing mutation; REEP1; Whole-exome sequencing | Adult; Family; Female; Heterozygote; Humans; Male; Membrane Transport Proteins; Middle Aged; Mutation; Pedigree; Phenotype; RNA Splicing; Spastic Paraplegia, Hereditary; complementary DNA; carrier protein; REEP1 protein, human; adult; ankle contracture; Article; asymptomatic disease; autosomal dominant inheritance; clinical article; clinical feature; DNA synthesis; female; flexion contracture; gene; gene mutation; genetic variability; hereditary motor sensory neuropathy; heterozygote; human; male; middle aged; phenotype; priority journal; REEP1 gene; restriction fragment length polymorphism; reverse transcription polymerase chain reaction; RNA splice site; RNA splicing; Sanger sequencing; whole exome sequencing; young adult; case report; family; genetics; hereditary motor sensory neuropathy; metabolism; mutation; pathophysiology; pedigree; RNA splicing | English | 2021 | 2021-01-10 | 10.1016/j.gene.2020.145129 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prognostic implication of PD-L1 polymorphisms in non-small cell lung cancer treated with radiotherapy | Background To investigate the impact of programmed death-ligand 1 (PD-L1) polymorphisms on the prognosis of non-small cell lung cancer (NSCLC) patients treated with curative radiotherapy. Methods Four single nucleotide polymorphisms (SNPs) (rs822336G>C, rs822337T>A, rs822338C>T, and rs2297136A>G) in the PD-L1 gene were evaluated in 124 NSCLC patients. Clinical stage was I in 28, II in 17, and III in 79 patients. Fifty-seven patients received radiotherapy alone, including 28 patients who received stereotactic body radiotherapy. Sixty-seven patients received sequential or concurrent chemoradiotherapy. Risk factors for survival outcomes were analyzed with the log-rank test and multivariate Cox proportional hazards models. Results The rs822336GC+CC genotype was associated with better overall survival (OS) (hazard ratio [HR] = 0.60, 95% confidence interval [CI] = 0.37-0.97, p = 0.036) and regional failure-free survival (RFFS) (HR = 0.32, 95% CI = 0.14-0.76, p = 0.009), compared with rs822336GG genotype. The rs822337TA+AA genotype was associated with better OS (HR =0.54, 95% CI = 0.34-0.88, p = 0.014), progression-free survival (PFS) (HR = 0.64, 95% CI = 0.41-0.99, p = 0.046), and RFFS (HR = 0.38, 95% CI = 0.17-0.81, p = 0.013), compared with rs822337TT genotype. Three SNPs (rs822336, rs822337, and rs822338) were in linkage disequilibrium. Combined GTC and GTT (GT*) haplotype was associated with significantly worse OS (p = 0.018), PFS (p = 0.044), and RFFS (p = 0.038), compared with those with other combined haplotypes. Patients with diplotypes of two GT* haplotypes showed significantly worse OS (p = 0.023) and RFFS (p = 0.014) than those with other diplotypes. Conclusions These findings suggest that PD-L1 polymorphisms could be predictive markers for NSCLC patients receiving radiotherapy. | Kang, Min Kyu; Lee, Shin Yup; Choi, Jin Eun; Do, Sook Kyung; Cho, Moon-June; Kim, Jun-Sang; Park, Jae Yong | Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea; Chungnam Natl Univ, Dept Radiat Oncol, Sch Med, Daejeon, South Korea | KANG, MIN KYU/ACI-8824-2022 | 57201933342; 49863712700; 37107028100; 56333658000; 7401727536; 35078813700; 58360293800 | shinyup@knu.ac.kr;jaeyong@knu.ac.kr; | CANCER MEDICINE | CANCER MED-US | 2045-7634 | 10 | 22 | SCIE | ONCOLOGY | 2021 | 4.711 | 43.1 | 0.17 | 2025-07-30 | 3 | 3 | non-small cell lung cancer; PD-L1; polymorphisms; radiotherapy | EXPRESSION; RADIATION; GENE | non-small cell lung cancer; PD-L1; polymorphisms; radiotherapy | Aged; Aged, 80 and over; B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prognosis; programmed death 1 ligand 1; CD274 protein, human; programmed death 1 ligand 1; adult; aged; Article; cancer patient; cancer prognosis; cancer radiotherapy; cancer staging; chemoradiotherapy; clinical evaluation; disease association; failure free survival; female; gene; genetic association; genotype; haplotype; human; major clinical study; male; non small cell lung cancer; overall survival; PD L1 gene; progression free survival; risk factor; single nucleotide polymorphism; stereotactic body radiation therapy; genetic polymorphism; genetics; lung tumor; middle aged; non small cell lung cancer; pathology; prognosis; single nucleotide polymorphism; very elderly | English | 2021 | 2021-11 | 10.1002/cam4.4329 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Sequential treatment of afatinib and osimertinib or other regimens in patients with advanced non-small-cell lung cancer harboring EGFR mutations: Results from a real-world study in South Korea | Objectives The optimal sequence for the administration of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for treating non-small cell lung cancer (NSCLC) is still unclear. This study aimed to evaluate the efficacy of sequential afatinib and osimertinib treatment in patients with NSCLC harboring EGFR mutations. Materials and methods Electronic records of patients with EGFR-mutated NSCLC, who were administered afatinib and osimertinib (group A) or other chemotherapy (group B) between October 2014 and 2019, across 16 hospitals in South Korea were reviewed. The primary outcome, time on treatment (TOT), secondary outcome, and overall survival (OS) were estimated using the Kaplan-Meier method and log-rank test. Multivariate analyses were performed using the Cox proportional hazards model. Results Of the 737 patients who received frontline afatinib treatment, 324 with complete records were selected (group A: 126, group B: 198). All patients in group A were T790M positive after afatinib, while patients in group B were all negative or unknown. The median TOT was 35.4 months (95% confidence interval [CI]: 27.7-45.6) in group A and 20.8 months (95% CI: 19.4-24.0) in group B. The median TOT with afatinib was 13.0 months (95% CI: 12.0-13.9) overall and 15.7 months (95% CI: 13.9-17.3) in group A. The 2- and 3-year survival rates were 86.0 and 69.3% in group A and 75.9 and 55.3% in group B, respectively. Conclusion Sequential afatinib and osimertinib treatment resulted in better survival rates than treatment with afatinib followed by other chemotherapies. | Kim, Taeyun; Jang, Tae Won; Choi, Chang Min; Kim, Mi-Hyun; Lee, Sung Yong; Park, Cheol-Kyu; Chang, Yoon Soo; Lee, Kye Young; Kim, Seung Joon; Yang, Sei Hoon; Ryu, Jeong Seon; Lee, Jeong Eun; Lee, Shin Yup; Park, Chan Kwon; Lee, Sang Hoon; Jang, Seung Hun; Yoon, Seong Hoon | Armed Forces Goyang Hosp, Dept Internal Med, Goyang Si, South Korea; Kosin Univ, Gospel Hosp, Dept Internal Med, Coll Med, 262 Gamcheon Ro, Busan 49267, South Korea; Ulsan Univ, Asan Med Ctr, Dept Internal Med, Seoul, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Pusan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Pusan, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Div Pulmonol Allergy & Crit Care Med, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Internal Med, Hwasun, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Seoul, South Korea; Konkuk Univ, Med Ctr, Dept Internal Med, Seoul, South Korea; Catholic Univ, Seoul St Marys Hosp, Dept Internal Med, Seoul, South Korea; Wonkwang Univ Hosp, Dept Internal Med, Iksan, South Korea; Inha Univ Hosp, Dept Internal Med, Incheon, South Korea; Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Internal Med, Daegu, South Korea; Catholic Univ, Yeouido St Marys Hosp, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Seoul, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Anyang, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Yangsan, South Korea | Kim, Jung Oh/JDC-5061-2023; Lee, Sang-Hoon/ABH-6210-2020; Park, Cheol-Kyu/AAT-9872-2021; Kim, Woo/A-8216-2019; Lee, Joo Yong/ADE-2110-2022; Kim, Taeyun/AAL-3477-2021; Lee, Jeong Eun/R-8689-2019 | 57213164256; 7102426031; 14024046800; 26323727500; 56734650000; 57205721111; 58293916800; 8720534800; 57225930594; 7406950928; 7401868634; 57209104622; 49863712700; 14623269200; 57207065392; 7402219050; 55479240500 | jangtw22@hanmail.net; | CANCER MEDICINE | CANCER MED-US | 2045-7634 | 10 | 17 | SCIE | ONCOLOGY | 2021 | 4.711 | 43.1 | 1.25 | 2025-07-30 | 16 | 16 | afatinib; EGFR; NSCLC; osimertinib; real-world data | ADENOCARCINOMA; SURVIVAL; SAFETY | afatinib; EGFR; NSCLC; osimertinib; real-world data | Acrylamides; Afatinib; Aged; Aniline Compounds; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; Female; Humans; Lung Neoplasms; Male; Mutation; Republic of Korea; afatinib; epidermal growth factor receptor; osimertinib; acrylamide derivative; afatinib; aniline derivative; epidermal growth factor receptor; osimertinib; adult; advanced cancer; aged; Article; cancer patient; cancer survival; clinical evaluation; drug efficacy; EGFR gene; electronic medical record; female; gene; gene mutation; human; major clinical study; male; non small cell lung cancer; South Korea; survival rate; treatment outcome; genetics; lung tumor; mutation; non small cell lung cancer; pathology | English | 2021 | 2021-09 | 10.1002/cam4.4127 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Validation of loop-mediated isothermal amplification to detectHelicobacter pyloriand 23S rRNA mutations: A prospective, observational clinical cohort study | Background Identifying point mutations in 23S rRNA closely associated with clarithromycin resistance can increase the eradication rate ofHelicobacter pylori(H pylori). In this study, we verified the sensitivity, specificity, and reliability of a newly developed loop-mediated isothermal amplification (LAMP) assay kit to detectH pyloriand 2143G and 2182C mutations in 23S rRNA. Methods LAMP assay to detectH pyloriand a mutant strain with 2143G and 2182C was conducted with the Isopollo(R)H pylori& ClaR kit. A prospective, open-label, observational study was conducted to validate the reliability of the LAMP assay in both a development cohort and a bedside direct LAMP cohort. Results The LAMP assay had good sensitivity, as it could detect as few as 10-100 copies ofH pyloriand mutants with 2143G and 2182C in 23S rRNA, and good specificity, as it did not react with other bacterial species. In the development cohort with 622 participants, the LAMP assay showed good agreement with RUT for detectingH pylori(kappa value 0.923,P < .001) and had exactly the same results as sequencing analysis for 2143G and 2182C point mutations. The direct LAMP cohort including 93 patients had 97.7% (42/43) of concordance in detecting 2143G and 2182C point mutations compared to the PCR-based sequencing analysis. Conclusion The Isopollo(R)H pylori& ClaR LAMP assay was a valid method for detectingH pyloriand for 2143G and 2182C point mutations in 23S rRNA in a clinical setting. | Park, Chang-Geun; Kim, Seohyeon; Jeon, Hyo-Sung; Han, Seungwoo | Daegu Fatima Hosp, Dept Internal Med, Daegu, South Korea; Mmonitor Inc, 62 Seongseogongdan Ro,11 Gil, Daegu 42713, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, 807 Hoguk Ro, Daegu 41404, South Korea | Han, Seungwoo/R-5326-2019 | 57203542123; 57203542057; 59108838200; 55246807000 | jeonh@mmonitor.net;kiefe73@gmail.com; | JOURNAL OF CLINICAL LABORATORY ANALYSIS | J CLIN LAB ANAL | 0887-8013 | 1098-2825 | 35 | 1 | SCIE | MEDICAL LABORATORY TECHNOLOGY | 2021 | 3.124 | 43.1 | 0.37 | 2025-07-30 | 5 | 4 | Helicobacter pylori; loop-mediated isothermal amplification; point mutation; validation | HELICOBACTER-PYLORI; GASTRIC-CANCER; CLARITHROMYCIN RESISTANCE; TRIPLE THERAPY; ERADICATION; PREVENTION; STRATEGY | Helicobacter pylori; loop-mediated isothermal amplification; point mutation; validation | Aged; Anti-Bacterial Agents; Clarithromycin; DNA, Bacterial; Drug Resistance, Bacterial; Female; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Molecular Diagnostic Techniques; Nucleic Acid Amplification Techniques; Point Mutation; Prospective Studies; Reproducibility of Results; RNA, Ribosomal, 23S; Sensitivity and Specificity; RNA 23S; antiinfective agent; bacterial DNA; clarithromycin; RNA 23S; adult; antibiotic resistance; Article; bacterial strain; cohort analysis; controlled study; cost effectiveness analysis; DNA extraction; female; gene mutation; Helicobacter infection; human; loop mediated isothermal amplification; major clinical study; male; middle aged; observational study; polymerase chain reaction; prospective study; sensitivity and specificity; sequence analysis; validation process; aged; drug effect; genetics; Helicobacter infection; Helicobacter pylori; microbiology; molecular diagnosis; nucleic acid amplification; point mutation; procedures; reproducibility | English | 2021 | 2021-01 | 10.1002/jcla.23563 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A new affinity matrix weighted k-nearest neighbors graph to improve spectral clustering accuracy | Researchers have thought about clustering approaches that incorporate traditional clustering methods and deep learning techniques. These approaches normally boost the performance of clustering. Getting knowledge from large data-sets is quite an interesting task. In this case, we use some dimensionality reduction and clustering techniques. Spectral clustering is gaining popularity recently because of its performance. Lately, numerous techniques have been introduced to boost spectral clustering performance. One of the most significant part of these techniques is to construct a similarity graph. We introduced weighted k-nearest neighbors technique for the construction of similarity graph. Using this new metric for the construction of affinity matrix, we achieved good results as we tested it both on real and artificial data-sets. | Ahmed, Muhammad Jamal; Saeed, Faisal; Paul, Anand; Jan, Sadeeq; Seo, Hyuncheol | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea; Univ Engn Technol Peshawar, Dept Comp Sci & IT, Peshawar, Pakistan; Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, Daegu, South Korea | ; Seo, Hyuncheol/ABC-5117-2020; Ahmed, Muhammad Jamal/LRC-8144-2024; Paul, Anand/V-6724-2017 | 57222549949; 58165089300; 56650522400; 57188653523; 56083741500 | paul.editor@gmail.com;charles@knu.ac.kr; | PEERJ COMPUTER SCIENCE | PEERJ COMPUT SCI | 2376-5992 | 7 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;COMPUTER SCIENCE, INFORMATION SYSTEMS;COMPUTER SCIENCE, THEORY & METHODS | 2021 | 2.411 | 43.2 | 0.31 | 2025-07-30 | 4 | 4 | K-nearest neighbors; Spectral clustering; Eigen decomposition; Affinity matrix | Affinity matrix; Data Science; Eigen decomposition; K-nearest neighbors; Spectral clustering | Cluster analysis; Clustering algorithms; Deep learning; Matrix algebra; Motion compensation; Nearest neighbor search; Text processing; Affinity matrix; Clustering accuracy; Clustering approach; Clustering methods; Eigen decomposition; K-near neighbor; Nearest-neighbour; Performance; Spectral clustering; Traditional clustering | English | 2021 | 2021-09-06 | 10.7717/peerj-cs.692 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Patients' experiences of asthma exacerbation and management: a qualitative study of severe asthma | Exacerbation is a defining feature of severe asthma, and oral corticosteroids (OCSs) are frequently prescribed to manage exacerbations. This qualitative study was conducted to examine the experience of patients with severe asthma, with a focus on asthma exacerbation and OCS treatment. Adults with severe asthma were recruited from three tertiary hospitals in South Korea. Data were collected through in-depth qualitative interviews. Verbatim transcripts were analysed using Colaizzi's phenomenological method to uncover the meaning of the participants' experience. Recruitment of participants continued until thematic saturation. 14 patients with severe asthma were recruited. Four theme clusters emerged: 1) experience of asthma exacerbation; 2) impact on life; 3) OCS treatments; and 4) disease perception. The patients experienced severe physical and psychosocial distress from asthma exacerbations, felt helpless due to failed efforts to prevent exacerbation and were living a restricted life due to fear of exacerbation. They feared OCS sideeffects but had no other choice than to rely on OCSs because other interventions were ineffective. Most had poor knowledge and understanding of severe asthma and the long-term health consequences. Asthma exacerbation affects wide aspects of life in patients with severe asthma. Several components may underlie reliance on OCSs, including experience of distress during exacerbation, fear of future exacerbation and lack of proper knowledge about the long-term health consequences of severe asthma and OCS treatments. A multi-disciplinary approach is warranted to support the patients and to provide systematic education about the long-term health implications of severe asthma. | Song, Woo-Jung; Won, Ha-Kyeong; Lee, Suh Young; Park, Han-Ki; Cho, You Sook; Chung, Kian Fan; Heaney, Liam G.; Joung, Woo Joung | Univ Ulsan, Asan Med Ctr, Dept Allergy & Clin Immunol, Coll Med, Seoul, South Korea; Vet Hlth Serv Med Ctr, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Allergy & Clin Immunol, Daegu, South Korea; Imperial Coll London, Natl Heart & Lung Inst, London, England; Royal Brompton & Harefield NHS Trust, London, England; Queens Univ Belfast, Ctr Expt Med, Sch Med Dent & Biomed Sci, Belfast, Antrim, North Ireland; Kyungpook Natl Univ, Coll Nursing, Res Inst Nursing Sci, Daegu, South Korea | Won, Ha-Kyeong/AFL-4811-2022; Chung, Kian/B-1872-2012; Park, Han-Ki/AAY-3102-2020 | 37062104600; 57192190852; 54684477700; 57218664064; 7404469543; 35403525000; 8921275400; 56319847900 | godblessed@knu.ac.kr; | ERJ OPEN RESEARCH | ERJ OPEN RES | 2312-0541 | 7 | 2 | SCIE | RESPIRATORY SYSTEM | 2021 | 4.239 | 43.2 | 1.65 | 2025-07-30 | 23 | 22 | QUESTIONNAIRE; PERCEPTIONS; KOREA | corticosteroid; adolescent; adult; anorexia; anxiety; Article; asthma; body weight loss; chronic bronchitis; chronic obstructive lung disease; cold sweat; depression; disease exacerbation; distress syndrome; dyspnea; emotional stress; forced expiratory volume; health behavior; heart failure; hemoptysis; human; hypertension; lung function; osteoporosis; psychosis; qualitative research; quality of life; rib fracture; self care; social support; spirometry; tertiary care center; thorax pain; validation process; voice change | English | 2021 | 2021-04-01 | 10.1183/23120541.00528-2020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Landscape Ecological Analysis of Green Network in Urban Area Using Circuit Theory and Least-Cost Path | Quantitative securing of green space in already developed cities has many practical limitations due to socio-economic limitations. Currently, South Korea is planning a green network to secure and inject effective green space, but it is difficult to reflect it in the actual space plan due to the abstract plan. This study utilizes circuit theory and least-cost path methods for presenting a green network that is objectified and applicable to spatial planning. First, an analysis of the Least-cost Path revealed 69 least-cost paths between 43 core green areas of the study site. Most least-cost paths have been identified as passing through small green areas and streams in the city. Using the circuit theory, it was also possible to distinguish areas other than least-cost paths from areas with high potential for development, areas where target species are concentrated within corridors. In particular, areas with relatively high green network improvement effects were derived within and around corridors. This study is most significant in establishing and evaluating existing urban green networks, overcoming the limitations discussed at the linear level and expanding to the area level. To increase the utilization of this study in the future, field surveys and monitoring studies on target species need to be supplemented. | Kwon, Oh-Sung; Kim, Jin-Hyo; Ra, Jung-Hwa | Gyeonggi Res Inst, Dept Ecol & Environm, Suwon 16207, South Korea; Korea Forest Conservat Assoc, Forestland Spatial Planning Div, Daejeon 35262, South Korea; Kyungpook Natl Univ, Dept Landscape Architecture, Daegu 41561, South Korea | 57226769032; 57226774198; 57226765126 | kos8282@gri.re.kr;gsjhk@kfca.re.kr;jhra@knu.ac.kr; | LAND | LAND-BASEL | 2073-445X | 10 | 8 | SSCI | ENVIRONMENTAL STUDIES | 2021 | 3.905 | 43.4 | 2.06 | 2025-07-30 | 24 | 26 | linkage mapper; centrality; pinch-point; barrier; connectivity | BIODIVERSITY CONSERVATION; LAND-USE; CONNECTIVITY; PERMEABILITY; RESTORATION; DIVERSITY; BIRDS; EPIDEMIOLOGY; PERSPECTIVE; WASHINGTON | Barrier; Centrality; Connectivity; Linkage mapper; Pinch-point | English | 2021 | 2021-08 | 10.3390/land10080847 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Planning Strategies of Wind Corridor Forests Utilizing the Properties of Cold Air | A wind corridor forest is defined as an urban forest for utilizing the functions of a wind corridor that allow "cool and fresh air (cold air)" generated in forests at night to flow to urban development areas. This study aims to provide planning strategies for implementing a wind corridor forest by analyzing current conditions in Haengbok City (HBC region), Sejong, South Korea. The HBC region had many wind-generating forests (WGF), wind-spreading forests (WSF), and wind-connecting forests (WCF), and secured the connections among the target areas of each wind corridor forest. Despite the favorable conditions for a wind corridor forest, cold air flow showed that there are regions with unfavorable wind conditions in the HBC region. In order to strengthen the functions of a wind corridor forests in the HBC region, four zones were distinguished according to the functional characteristics. Additionally, the planning strategies of a wind corridor forests suitable for each zone were provided, and the strategies for establishing a wind corridor forest were proposed. The results of this study can be used as the fundamental data for establishing guidelines for a wind corridor forest and utilized as resources for selecting regions suitable for a wind corridor forest. | Sung, Uk-Je; Eum, Jeong-Hee; Son, Jeong-Min; Oh, Jeong-Hak | Kyungpook Natl Univ, Dept Landscape Architecture, 80 Daehak Ro, Daegu 41566, South Korea; Natl Inst Forest Sci, Div Urban Forests, 57 Hoegi Ro, Seoul 02455, South Korea | EUM, JH/IWE-0201-2023 | 57224731922; 55322972500; 57204964199; 57224724918 | ukje1008@knu.ac.kr;eumjh@knu.ac.kr;sonjm1993@knu.ac.kr;jehoh@korea.kr; | LAND | LAND-BASEL | 2073-445X | 10 | 6 | SSCI | ENVIRONMENTAL STUDIES | 2021 | 3.905 | 43.4 | 0.89 | 2025-07-30 | 10 | 10 | urban forest; ventilation corridor; forest planning; KALM; climate change | THERMAL ENVIRONMENT; URBAN; TEMPERATURE; CLIMATE; SEOUL | Climate change; Forest planning; KALM; Urban forest; Ventilation corridor | English | 2021 | 2021-06 | 10.3390/land10060607 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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