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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Trichloroethanol, an active metabolite of chloral hydrate, modulates tetrodotoxin-resistant Na⁺ channels in rat nociceptive neurons | BackgroundChloral hydrate is a sedative-hypnotic drug widely used for relieving fear and anxiety in pediatric patients. However, mechanisms underlying the chloral hydrate-mediated analgesic action remain unexplored. Therefore, we investigated the effect of 2 ',2 ',2 '-trichloroethanol (TCE), the active metabolite of chloral hydrate, on tetrodotoxin-resistant (TTX-R) Na+ channels expressed in nociceptive sensory neurons.MethodsThe TTX-R Na+ current (I-Na) was recorded from acutely isolated rat trigeminal ganglion neurons using the whole-cell patch-clamp technique.ResultsTrichloroethanol decreased the peak amplitude of transient TTX-R I-Na in a concentration-dependent manner and potently inhibited persistent components of transient TTX-R I-Na and slow voltage-ramp-induced I-Na at clinically relevant concentrations. Trichloroethanol exerted multiple effects on various properties of TTX-R Na+ channels; it (1) induced a hyperpolarizing shift on the steady-state fast inactivation relationship, (2) increased use-dependent inhibition, (3) accelerated the onset of inactivation, and (4) retarded the recovery of inactivated TTX-R Na+ channels. Under current-clamp conditions, TCE increased the threshold for the generation of action potentials, as well as decreased the number of action potentials elicited by depolarizing current stimuli.ConclusionsOur findings suggest that chloral hydrate, through its active metabolite TCE, inhibits TTX-R I-Na and modulates various properties of these channels, resulting in the decreased excitability of nociceptive neurons. These pharmacological characteristics provide novel insights into the analgesic efficacy exerted by chloral hydrate. | Kim, Gimin; Kim, Hyunjung; Jang, Il-Sung | Kyungpook Natl Univ, Sch Dent, Dept Pediat Dent, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, 2177 Dalgubeol daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41940, South Korea | 57210885969; 57196215346; 7102177910 | jis7619@knu.ac.kr; | BMC ANESTHESIOLOGY | BMC ANESTHESIOL | 1471-2253 | 23 | 1 | SCIE | ANESTHESIOLOGY | 2023 | 2.3 | 33.6 | 0.26 | 2025-06-25 | 1 | 1 | Chloral hydrate; Trichloroethanol; Analgesia; TTX-R Na+ channels; Nociceptive neurons; Patch clamp | PERSISTENT SODIUM CURRENTS; PROCEDURAL SEDATION; GENERAL-ANESTHETICS; RECOMBINANT GABA(A); BURST GENERATION; RAMP CURRENTS; V NEURONS; INACTIVATION; EXCITABILITY; KINETICS | Analgesia; Chloral hydrate; Nociceptive neurons; Patch clamp; Trichloroethanol; TTX-R Na<sup>+</sup> channels | Animals; Chloral Hydrate; Ganglia, Spinal; Membrane Potentials; Nociceptors; Rats; Rats, Sprague-Dawley; Sodium Channels; Tetrodotoxin; sodium channel; tetrodotoxin; trichloroethanol; 2,2,2-trichloroethanol; chloral hydrate; sodium channel; tetrodotoxin; action potential; analgesic activity; animal cell; Article; cell isolation; concentration (parameter); controlled study; current clamp technique; nerve cell; neuromodulation; nociception; nonhuman; rat; whole cell patch clamp; animal; membrane potential; metabolism; pain receptor; physiology; spinal ganglion; Sprague Dawley rat | English | 2023 | 2023-04-29 | 10.1186/s12871-023-02105-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Editorial Material | Comment on "Multiparty quantum mutual information: An alternative definition" | We show that, contrary to the claim by Kumar [Phys. Rev. A 96, 012332 (2017)], the quantum dual total correlation of an n-partite quantum state cannot be represented as the quantum relative entropy between n - 1 copies of the quantum state and the product of n different reduced quantum states for n >= 3. Specifically, we argue that the latter fails to yield a finite value for generalized n-partite Greenberger-Horne-Zeilinger states. | Lee, Jaehak; Noh, Gibeom; Noh, Changsuk; Park, Jiyong | Seoul Natl Univ, Dept Phys & Astron, Seoul 08826, South Korea; Korea Inst Sci & Technol, Ctr Quantum Informat, Seoul 02792, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Hanbat Natl Univ, Sch Basic Sci, Daejeon 34158, South Korea | Lee, Jaehak/AAE-4103-2020; Park, Jiyong/G-1011-2010 | 57206732383; 58804034000; 23991025500; 55716975600 | jaehak.lee.201@gmail.com;jiyong.park@hanbat.ac.kr; | PHYSICAL REVIEW A | PHYS REV A | 2469-9926 | 2469-9934 | 108 | 6 | SCIE | OPTICS;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2023 | 2.6 | 33.7 | 0.05 | 2025-06-25 | 0 | 1 | ENTROPY | Greenberger-Horne-Zeilinger state; Mutual informations; N-partite; Quantum relative entropies; Quantum state | English | 2023 | 2023-12-27 | 10.1103/physreva.108.066401 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Development of Muller cell-based 3D biomimetic model using bioprinting technology | Muller cells are the principal glial cells for the maintenance of structural stability and metabolic homeostasis in the human retina. Although various in vitro experiments using two-dimensional (2D) monolayer cell cultures have been performed, the results provided only limited results because of the lack of 3D structural environment and different cellular morphology. We studied a Muller cell-based 3D biomimetic model for use in experiments on the in vivo-like functions of Muller cells within the sensory retina. Isolated primary Muller cells were bioprinted and a 3D-aligned architecture was induced, which aligned Muller cell structure in retinal tissue. The stereographic and functional characteristics of the biomimetic model were investigated and compared to those of the conventional 2D cultured group. The results showed the potential to generate Muller cell-based biomimetic models with characteristic morphological features such as endfeet, soma, and microvilli. Especially, the 3D Muller cell model under hyperglycemic conditions showed similar responses as observed in the in vivo diabetic model with retinal changes, whereas the conventional 2D cultured group showed different cytokine and growth factor secretions. These results show that our study is a first step toward providing advanced tools to investigate the in vivo function of Muller cells and to develop complete 3D models of the vertebrate retina. | Jung, Sung Suk; Son, Jeonghyun; Yi, Soo Jin; Kim, Kyungha; Park, Han Sang; Kang, Hyun-Wook; Kim, Hong Kyun | Anim & Plant Quarantine Agcy, 177 Hyeoksin 8 Ro, Gimcheon City 39660, Gyeongsangbug D, South Korea; Ulsan Natl Inst Sci & Technol, 50 UNIST Gil, Ulsan 44919, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Biomed Inst, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, 680 Gukchaebosang Ro, Daegu 41944, South Korea | Jung, Sungsuk/HPE-3526-2023; Kang, Hyun-Wook/AAY-1766-2021; Kim, Hong Kyun/ITT-7758-2023 | 57195258092; 57209740277; 56783537100; 57214687326; 57208186456; 57203618619; 57218260940 | hkang@unist.ac.kr;okeye@knu.ac.kr; | BIOMEDICAL MATERIALS | BIOMED MATER | 1748-6041 | 1748-605X | 18 | 1 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2023 | 3.9 | 33.7 | 0.91 | 2025-06-25 | 6 | 8 | Muller cell; biomimetic model; retina; bioprinting | RETINAL GLIAL-CELLS; EXPRESSION; KIR4.1; AQUAPORIN-4; MECHANISMS; DISEASE; PROTEIN; VEGF | biomimetic model; bioprinting; Müller cell; retina | Biomimetics; Bioprinting; Ependymoglial Cells; Humans; Neuroglia; Retina; 3D modeling; Biomimetics; Cell culture; Ophthalmology; Stability; advanced glycation end product receptor; aquaporin 4; cytokine; fibrinogen; glial fibrillary acidic protein; growth factor; phalloidin; polycaprolactone; vimentin; Biomimetic model; Bioprinting; Cell-based; Cell-be; Cell/B.E; Cell/BE; Glial cells; In-vivo; Mülle cell; Retina; animal cell; animal tissue; Article; biomimetics; cell isolation; cell structure; cell viability; controlled study; eyeball; fluorescence activated cell sorting; fluorescence microscopy; gene expression; gene expression level; in vitro study; in vivo study; Mueller cell; nonhuman; rat; retina tissue; retinal pigment epithelium; three dimensional bioprinting; two dimensional cell culture; biomimetics; bioprinting; glia; human; macroglia; metabolism; procedures; retina; Cells | English | 2023 | 2023-01-01 | 10.1088/1748-605x/aca0d5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Fast scintillating Ce3+ doped gadolinium aluminum fluoroborate glass for calorimetry in proton CT prototype: A preliminary work | In this work, Ce3+-doped gadolinium aluminum fluoroborate glass scintillators, 25Gd2O3-(65-x)B2O3–10AlF3-xCeF3, where, x = 0, 0.05, 0.1, 0.2, and, 0.3 mol%, were prepared and studied systematically for developing a proton calorimeter used in proton-computed tomography. Various properties of the prepared glass scintillators were evaluated through density, X-ray absorption near edge spectroscopy, transmittance, photoluminescence, decay time, X-ray-induced luminescence, and proton-induced luminescence measurements. The highest density of the fabricated glass scintillators reached 4.31 g/cm3. The X-ray-induced luminescence showed a broad emission band centered at approximately 400 nm, and the decay time was less than 30 ns. The glass scintillators were irradiated by a proton beam with a beam energy of 100–115 MeV. It was found that the glass scintillators emitted light at almost the same wavelength as that of the X-ray-induced luminescence. Moreover, the energy deposition inside the fabricated glass scintillators was simulated using GATE simulation and compared with the results obtained for proton-induced luminescence. The energy deposition obtained from the simulation showed the same trend as that for the fraction of light emitted from the proton irradiation measurement. Therefore, these fabricated glass scintillators can be used as calorimeter in medical physics and other applications related to proton or X-ray irradiation. © 2023 Elsevier Ltd | Boontueng, P.; Ritjoho, N.; Wantana, N.; Limkitjaroenporn, P.; Kim, H.J.; Sanghangthum, T.; Chanlek, N.; Limphirat, A.; Yan, Y.; Kaewkhao, J.; Kobdaj, C. | School of Physics, Suranaree University of Technology (SUT), Nakhon Ratchasima, 30000, Thailand; School of Physics, Suranaree University of Technology (SUT), Nakhon Ratchasima, 30000, Thailand; Physics Program, Faculty of Science and Technology, Nakhon Pathom Rajabhat University (NPRU), Nakhon Pathom, 73000, Thailand, Center of Excellence in Glass Technology and Materials Science (CEGM), Nakhon Pathom Rajabhat University, Nakhon Pathom, 73000, Thailand; Physics Program, Faculty of Science and Technology, Nakhon Pathom Rajabhat University (NPRU), Nakhon Pathom, 73000, Thailand, Center of Excellence in Glass Technology and Materials Science (CEGM), Nakhon Pathom Rajabhat University, Nakhon Pathom, 73000, Thailand; Department of Physics, Kyungpook National University (KNU), Daegu, 702-701, South Korea; Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand; Synchrotron Light Research Institute (SLRI), Nakhon Ratchasima, 30000, Thailand; School of Physics, Suranaree University of Technology (SUT), Nakhon Ratchasima, 30000, Thailand; School of Physics, Suranaree University of Technology (SUT), Nakhon Ratchasima, 30000, Thailand; Physics Program, Faculty of Science and Technology, Nakhon Pathom Rajabhat University (NPRU), Nakhon Pathom, 73000, Thailand, Center of Excellence in Glass Technology and Materials Science (CEGM), Nakhon Pathom Rajabhat University, Nakhon Pathom, 73000, Thailand; School of Physics, Suranaree University of Technology (SUT), Nakhon Ratchasima, 30000, Thailand | 59182608000; 57204908345; 56267058700; 35362361700; 59051568100; 15725955100; 24775167600; 26644137200; 7404585672; 23974520300; 57194221209 | kobdaj@g.sut.ac.th;jakrapong@webmail.npru.ac.th; | Radiation Measurements | RADIAT MEAS | 1350-4487 | 1879-0925 | 163 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2023 | 1.6 | 33.7 | 2.87 | 2025-06-25 | 15 | Ce<sup>3+</sup>; Gadolinium aluminum fluoroborate glass; Proton-induced luminescence; X-ray-induced luminescence | Aluminum compounds; Calorimeters; Computerized tomography; Deposition; Glass; Scintillation; Scintillation counters; X ray absorption; Ce 3+; Energy depositions; Fluoroborate glass; Gadolinia aluminum fluoroborate glass; Glass scintillator; Photoluminescence decay time; Property; Proton-induced luminescence; X-ray absorption near edge spectroscopy; X-ray-induced luminescence; Ionization | English | Final | 2023 | 10.1016/j.radmeas.2023.106937 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Editorial Material | Proposal of Isolated Ultrasonography Room Model for the Examination of Pregnant Women With Confirmed Coronavirus Disease 2019 | Kim, Mi Ju; Kim, Hyun Mi; Cha, Hyun Hwa; Kwon, Ki Tae; Seong, Won Joon | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Obstet & Gynecol, 807 Hogukro, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Div Infect Dis,Dept Internal Med, Daegu, South Korea | Kim, Mi Ju/HGU-8470-2022; Hwang, Soyoon/HHM-5762-2022 | 55908927600; 57219838830; 37033517800; 9733850500; 26656946000 | wjseong@knu.ac.kr; | JOURNAL OF ULTRASOUND IN MEDICINE | J ULTRAS MED | 0278-4297 | 1550-9613 | 42 | 5 | SCIE | ACOUSTICS;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2023 | 2.1 | 33.7 | 0 | 2025-06-25 | 0 | 0 | UNITED-STATES; COVID-19; OUTCOMES | COVID-19; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Pregnant Women; SARS-CoV-2; Ultrasonography; diagnostic imaging; echography; female; human; pregnancy; pregnancy complication; pregnant woman | English | 2023 | 2023-05 | 10.1002/jum.16003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Quantum synchronization effects induced by strong nonlinearities | A paradigm for quantum synchronization is the quantum analog of the Stuart-Landau oscillator, which corresponds to a van der Pol oscillator in the limit of weak (i.e., vanishingly small) nonlinearity. Due to this limitation, the quantum Stuart-Landau oscillator fails to capture interesting nonlinearity-induced phenomena such as relaxation oscillations. To overcome this deficiency, we propose an alternative model that approximates the Duffing-van der Pol oscillator to finitely large nonlinearities while remaining numerically tractable. This allows us to uncover interesting phenomena in the deep-quantum strongly nonlinear regime with no classical analog, such as the persistence of amplitude death on resonance. We also report nonlinearity-induced position correlations in reactively coupled quantum oscillators. Such coupled oscillations become more and more cor-related with increasing nonlinearity before reaching some maximum. Again, this behavior is absent classically. We also show how strong nonlinearity can enlarge the synchronization bandwidth in both single and coupled oscillators. This effect can be harnessed to induce mutual synchronization between two oscillators initially in amplitude death. | Shen, Yuan; Mok, Wai-Keong; Noh, Changsuk; Liu, Ai Qun; Kwek, Leong-Chuan; Fan, Weijun; Chia, Andy | Nanyang Technol Univ, Sch Elect & Elect Engn, Block S2 1, 50 Nanyang Ave, Singapore 639798, Singapore; Natl Univ Singapore, Ctr Quantum Technol, Singapore, Singapore; CALTECH, Pasadena, CA 91125 USA; Kyungpook Natl Univ, Dept Phys, Daegu, South Korea; Nanyang Technol Univ, MajuLab, CNRS,Int Joint Res Unit, UNS,NUS, UMI 3654, Singapore, Singapore; Nanyang Technol Univ, Natl Inst Educ, Singapore 637616, Singapore; Nanyang Technol Univ, Quantum Sci & Engn Ctr QSec, Singapore, Singapore | Kwek, Leong-Chuan/P-2303-2014; Liu, Aiqun/A-5066-2011 | 57216894786; 57209076418; 23991025500; 7402583739; 7006483792; 35956227400; 57193651505 | eaqliu@ntu.edu.sg;kwekleongchuan@nus.edu.sg;ewjfan@ntu.edu.sg; | PHYSICAL REVIEW A | PHYS REV A | 2469-9926 | 2469-9934 | 107 | 5 | SCIE | OPTICS;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2023 | 2.6 | 33.7 | 1.43 | 2025-06-25 | 9 | 9 | Circuit oscillations; Lyapunov methods; Oscillators (mechanical); Amplitude death; Duffing-van der Pol oscillator; Non-linear regimes; Numerically tractable; Quantum analog; Relaxation oscillation; Small nonlinearities; Strong nonlinearity; Strongly nonlinear; Van der Pol's oscillators; Synchronization | English | 2023 | 2023-05-23 | 10.1103/physreva.107.053713 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Synthesis, structure and luminescence properties of bifunctional KCaF3 phosphor influenced by incorporating Eu3+ions for solid state lighting and TL dosimetry applications | Europium doped KCaF3 phosphors (KCaF3:Eu3+) were prepared using various concentrations of Eu3+ by con-ventional solid-state reaction process. The X-ray diffraction (XRD) studies confirmed the formation of ortho-rhombic structured KCaF3:Eu3+ phosphors. Scanning Electron Microscopy (SEM) image of the synthesized phosphor exhibits agglomerated particles with irregular shapes. The composition of the synthesized sample was determined by Energy Dispersive Spectroscopy (EDS) spectrum and elemental mapping showed the homoge-neous dispersion of Eu3+ ions into the synthesized KCaF3:Eu3+ phosphor. The emission peak intensity at 594 nm from photoluminescence (PL) spectra was found to increase with the increase of Eu3+ concentrations from 0.02 mol% to 0.06 mol% and decreased with the further increase of Eu3+ concentration up to 0.1 mol%. CIE1931 chromaticity diagram coordinates (x, y) of KCaF3:(0.06 mol%) Eu3+ phosphors were positioned in the reddish -orange region (x = 0.5736, y = 0.4224). Photoluminescence property confirms the suitability of KCaF3:Eu3+ phosphors for Solid state lighting application. X-ray induced luminescence (radioluminescence, RL) is recorded for KCaF3:Eu3+ phosphors showing the characteristic emission of Eu2+ and Eu3+. ESR study on KCaF3:Eu3+ phosphors confirm the presence of Eu2+ ions. Beta irradiated thermoluminescence (TL) glow curve of Eu3+ doped KCaF3 phosphors is measured and deconvoluted using Gaussian fitting. TL kinetic parameters like activation energy (Ea) and frequency factor (s) are calculated for all the deconvoluted peaks using peak shape method which shows the synthesized KCaF3:Eu3+ phosphors is suitable for dosimetry application. | Kameshwaran, R.; Raja, A.; Kumar, R. Ramesh; Daniel, D. Joseph; Annalakshmi, D. O.; Aravinth, K.; Bhargav, P. Balaji; Ramasamy, P. | Sri Sivasubramaniya Nadar Coll Engn, Dept Phys, Kalavakkam 603110, Tamil Nadu, India; Univ Salerno I, CNR SPIN, I-84084 Salerno, Italy; Kyungpook Natl Univ, Inst High Energy & Nanophys, Dept Phys, Daegu 702701, South Korea; Indira Gandhi Ctr Atom Res, Radiol Safety Div, Kalpakkam 603102, Tamil Nadu, India | Raja, Arumugam/Q-1781-2019; KUMAR, RAKESH/N-4471-2014; Karuppannan, Aravinth/JZE-2048-2024; Ramasamy, Prakash/AGT-2329-2022; Bhargav, Balaji/IUO-6496-2023; Aravinth, K/JZE-2048-2024 | aravinthk@ssn.edu.in; | APPLIED RADIATION AND ISOTOPES | APPL RADIAT ISOTOPES | 0969-8043 | 1872-9800 | 191 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR;NUCLEAR SCIENCE & TECHNOLOGY;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2023 | 1.6 | 33.7 | 17 | Fluoroperovskite; Photoluminescence; Energy transfer; Thermoluminescence; Activation energy | PHOTOLUMINESCENCE PROPERTIES; ENERGY-TRANSFER; OPTICAL-PROPERTIES; RED PHOSPHORS; RADIOLUMINESCENCE; IRRADIATION; PEROVSKITE; KMGF3; TB3+; EU2+ | English | 2023 | 2023-01 | 10.1016/j.apradiso.2022.110520 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | Article | Health benefits of co-supplementing mealworm protein hydrolysate and cranberry fruit extract | The demand for valuable protein sources is increasing. The mealworm has been highlighted as a good source of protein. Nevertheless, beneficial effects of mealworm such as the antioxidative and/or anti-inflammatory effects are rarely studied. It is well-known that cranberry fruit has a strong antioxidant effect. The biologically active compounds in mealworm and cranberry could boost the antioxidative and/or anti-inflammatory effects. The current study investigated the interactive effects of mealworm protein hydrolysate (MWPH) and cranberry fruit extract (CFE) in mammals. We evaluated growth performance, relative organ weight, immune responses, antioxi-dant enzyme activities, blood properties, and fecal microflora. A 2 x 2 factorial experimental design was used. The co-supplementation of MWPH and CFE improved serum glutathione peroxidase. MWPH affected a lower serum IL-1 beta and fecal Clostridium density. The co-supplementation appeared more effective in terms of good health and potentially the prevention of disease. | Park, Jae Hong; Lee, Sang In; Kwon, Woo Sung; Cho, Sungbo; Kim, In Ho | Dankook Univ, Dept Anim Resource & Sci, Cheonan 31116, South Korea; Kyungpook Natl Univ, Dept Anim Biotechnol, Sangju, South Korea; Inner Mongolia Univ Nationalities, Sch Mongolian Med, Tongliao 028000, Inner Mongolia, Peoples R China | ; Kwon, Woo-Sung/J-6731-2019; Kim, Hee/F-4594-2014 | blue0555@hotmail.com;inhokim@dankook.ac.kr; | ITALIAN JOURNAL OF FOOD SCIENCE | ITAL J FOOD SCI | 1120-1770 | 2239-5687 | 35 | 1 | SCIE | FOOD SCIENCE & TECHNOLOGY | 2023 | 3.6 | 33.8 | 3 | cranberry; extracts; immunity; inflammation; mealworm; microbiota | CHITIN; ANTIOXIDANT; PRODUCTS; CHITOSAN; DISEASE; BODY | English | 2023 | 2023 | 10.15586/ijfs.v35i1.2264 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Promotional effect of ammonium chloride functionalization on the performance of polyethersulfone/chitosan composite-based ultrafiltration membrane | This study aims to determine the effect of ammonium chloride (NH4Cl) on the char-acteristics and performance of polyethersulfone (PES)/Chitosan (CS)-based ultrafiltration composite membranes. The PES membranes were synthesized using phase inversion technique in dimethylacetamide (DMAc) solvent. A mixture of chitosan solution (fixed concentration) and NH4Cl (concentration 100-400 ppm) with ratio 2:1 (v/v) were coated into the PES membrane. The synthesized membranes morphology and properties were characterized by FTIR, SEM, contact angle, mechanical properties, and porosity tests. The membrane performance parameters including water permeability, rejection, and anti-fouling properties were studied. Incorporation of NH4Cl modified the membrane mor-phology and improved membrane porosity (49.64-71.5 %). The decrease in the water contact angle (80.21 degrees to 63.53 degrees) has confirmed the improvement of membrane hydro-philicity. Moreover, improved mechanical properties (11-16 MPa) were observed due to NH4Cl addition. The incorporation of NH4Cl improved water flux and specific flux mem-branes in dead-end cell from 51.34 to 159.18 L/m2 h and 22-26.53 L/m2 h bar, respectively, and in the cross-flow cell from 82.38 to 182.53 L/m2 h and from 16.47 to 36.51 L/m2 h bar, respectively. The addition of NH4Cl into membrane remarkably improved the rejection of bovine serum albumine (75.90 %, to 96.79 %), methyl orange (47.18-89.29 %), and methy-lene blue (60.14-97.34 %) Composite membranes have good fouling resistance as indicated by an increase in the flux recovery ratio (53.58-70.67 %). It is inferred that the addition of NH4Cl improved the performance of PES/chitosan composite membranes in ultrafiltration.(c) 2022 Institution of Chemical Engineers. Published by Elsevier Ltd. All rights reserved. | Khoerunnisa, Fitri; Amanda, Putri Citra; Nurhayati, Mita; Hendrawan, Hendrawan; Lestari, Witri Wahyu; Sanjaya, Eli Hendrik; Handayani, Murni; Oh, Wen -Da; Lim, JitKang | Indonesia Univ Educ, Dept Chem, Bandung 40154, Indonesia; Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, Sangju Si, Gyeongsangbuk D, South Korea; Univ Sebelas Maret, Fac Math & Nat Sci, Dept Chem, Jl Ir Sutami 36A, Surakarta 57126, Central Java, Indonesia; Univ Negeri Malang, Dept Chem, Malang 65145, Indonesia; Res Ctr Adv Mat Natl Res & Innovat Agcy BRIN, Tangerang Selatan 15314, Indonesia; Univ Sains Malaysia, Sch Chem Sci, George Town 11800, Malaysia; Univ Sains Malaysia, Sch Chem Engn, Engn Campus, Nibong Tebal 14300, Pulau Pinang, Malaysia | ; Handayani, Murni/AAV-8997-2020; Hendrawan, Hendrawan/GOJ-8304-2022; Nurhayati, Mita/GOJ-8523-2022; Lestari, Witri/AAY-7150-2020; Lim, Jit/G-3771-2010; Oh, Wen-Da/X-5294-2019; Sanjaya, Eli/ABE-4082-2021; Khoerunnisa, Fitri/GOJ-8479-2022 | 36675148400; 58532730300; 57222139830; 6506917385; 57197832621; 57191636626; 57202087591; 57205433398; 59629023200 | fitri@upi.edu;ohwenda@usm.my; | CHEMICAL ENGINEERING RESEARCH & DESIGN | CHEM ENG RES DES | 0263-8762 | 1744-3563 | 190 | SCIE | ENGINEERING, CHEMICAL | 2023 | 3.7 | 33.8 | 0.72 | 2025-06-25 | 5 | 7 | Ultrafiltration membrane; PES; CS; NH 4 Cl; Permeability; Selectivity; Antifouling | NANOFILTRATION MEMBRANE; COAGULATION; REMOVAL | Antifouling; Permeability; PES/CS/NH<sub>4</sub>Cl; Selectivity; Ultrafiltration membrane | Aromatic compounds; Azo dyes; Biomechanics; Composite membranes; Contact angle; Mammals; Morphology; Porosity; Ultrafiltration; Anti-foulings; Chitosan composites; Performance; Permeability; Poly(ether sulfone); Polyether sulfone; Polyethersulphone/chitosan/NH4cl; Selectivity; Ultra-filtration membranes; Ultrafiltration membranes; Chlorine compounds | English | 2023 | 2023-02 | 10.1016/j.cherd.2022.12.040 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Assessment of genetic polymorphisms associated with malaria antifolate resistance among the population of Libreville, Gabon | BackgroundGabon is a malaria-threatened country with a stable and hyperendemic transmission of Plasmodium falciparum monoinfection. Malaria drug resistance is widely spread in many endemic countries around the world, including Gabon. The molecular surveillance of drug resistance to antifolates and artemisinin-based combination therapy (ACT) is one of the strategies for combating malaria. As Plasmodium parasites continue to develop resistance to currently available anti-malarial drugs, this study evaluated the frequency of the polymorphisms and genetic diversity associated with this phenomenon among the parasites isolates in Gabon.MethodsTo assess the spread of resistant haplotypes among the malaria-infected population of Libreville, single nucleotide polymorphisms linked to sulfadoxine-pyrimethamine (SP) and artemisinin drugs resistance were screened for P. falciparum dihydrofolate reductase (Pfdhfr), P. falciparum dihydropteroate synthase (Pfdhps), and P. falciparum kelch 13-propeller domain (Pfk13) point mutations.ResultsThe analysis of 70 malaria-positive patient samples screened for polymorphism showed 92.65% (n = 63) mutants vs. 7.35% (n = 5) wild parasite population in Pfdhfr, with high prevalence mutations at S108N(88.24%, n = 60), N51I(85.29%, n = 58), C59R(79.41%, n = 54); however, I164L(2.94%, n = 2) showed low frequency mutation. No wild haplotype existed for Pfdhps, and there were no mutations at the K540E, A(581)G, and A(613)T/S positions. However, the mutation rate at A(437)G(93.38%, n = 62) was the highest, followed by S(436)A/F(15.38%, n = 10). A higher frequency of quadruple IRNI-SGKAA (69.84%) than quintuple IRNI-(A/F)GKAA (7.94%) mutations was observed in the Pfdhfr-Pfdhps combination. Furthermore, none of the mutations associated with ACT resistance, especially those commonly found in Africa, were observed in Pfk13.ConclusionsHigh polymorphism frequencies of Pfdhfr and Pfdhps genes were observed, with alternative alanine/phenylalanine mutation at S(436)A/F (7.69%, n = 5) for the first time. Similar to that of other areas of the country, the patterns of multiple polymorphisms were consistent with selection owing to drug pressure. Although there was no evidence of a medication failure haplotype in the studied population, ACT drug efficacy should be regularly monitored in Libreville, Gabon. | Dinzouna-Boutamba, Sylvatrie-Danne; Iroungou, Berthe Amelie; Akombi, Falone Larissa; Yacka-Mouele, Lauriane; Moon, Zin; Aung, Ja Moon; Lee, Sanghyun; Chung, Dong-Il; Hong, Yeonchul; Goo, Youn-Kyoung | Kyungpook Natl Univ, Sch Med, Dept Parasitol & Trop Med, Daegu 41944, South Korea; Ctr Int Rech Med Franceville & Serv Sante Mil, Unite Mixte Rech, Libreville 20404, Gabon; Korea Dis Control & Prevent Agcy, Korea Natl Inst Hlth, Dept Precis Med, Div Bio Bigdata, Cheongju 28159, South Korea | 56299947300; 40261633400; 57200413751; 57148199700; 57223389298; 57218245601; 56272461500; 13310373300; 7403392847; 22937863200 | kuku1819@knu.ac.kr; | MALARIA JOURNAL | MALARIA J | 1475-2875 | 22 | 1 | SCIE | INFECTIOUS DISEASES;PARASITOLOGY;TROPICAL MEDICINE | 2023 | 2.4 | 33.9 | 0.45 | 2025-06-25 | 3 | 2 | Malaria; Mutation; Haplotypes; Artemisinin combination therapy; Resistance; Libreville | ANTIMALARIAL-DRUG RESISTANCE; PLASMODIUM-FALCIPARUM; HIGH PREVALENCE; ARTEMISININ RESISTANCE; K13-PROPELLER POLYMORPHISMS; DIHYDROPTEROATE SYNTHASE; DIHYDROFOLATE-REDUCTASE; PREGNANT-WOMEN; FIELD SAMPLES; MUTATIONS | Artemisinin combination therapy; Haplotypes; Libreville; Malaria; Mutation; Resistance | Artemisinins; Folic Acid Antagonists; Gabon; Humans; Malaria; Malaria, Falciparum; Polymorphism, Single Nucleotide; alanine; artemisinin; folic acid antagonist; phenylalanine; pyrimethamine plus sulfadoxine; artemisinin derivative; folic acid antagonist; antimalarial drug resistance; artemisinin based combination therapy; Article; combination drug therapy; Gabon; gene; genetic polymorphism; haplotype; human; malaria; mutation rate; nonhuman; Pfdhfr gene; Pfdhps gene; Pfk13 gene; Plasmodium falciparum; point mutation; single nucleotide polymorphism; malaria; malaria falciparum | English | 2023 | 2023-06-14 | 10.1186/s12936-023-04615-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects and safety of virtual reality-based mindfulness in patients with psychosis: a randomized controlled pilot study | Virtual reality (VR) technology can be a supporting tool to enhance mindfulness. Recently, many research using VR-based mindfulness (VBM) has been carried out in various psychiatric disorders but not in psychosis. We investigated safety and effects of virtual reality-based mindfulness (VBM) in patients with psychosis as a pilot study. Sixty-four patients were randomly assigned to VBM or to VR control. For VBM, education and meditation videos were provided. For VR control, 3-dimensional natural scenes were shown. Both programs consisted of 8 weekly sessions, each lasting about 30min. Pre- and post-assessments were performed using the experiences questionnaire (EQ), psychotic symptom rating scales-delusion (PSYRATS-D), PSYRATS-auditory hallucinations (AH), motivation and pleasure scale-self rating (MAP-SR) and etc. The safety questionnaire was also surveyed after 1st and 8th session. Physiological measures such as skin conductance level (SCL), heart rate (HR) and RR interval, were collected during the VR interventions. Limited individuals participated in the safety questionnaire and physiological measures. All the results were presented in mean and standard deviation. We did not observe significant results in group x time interaction and main effects of group and time in the decentering and clinical scales. However, within group comparison showed that patients randomized to VBM showed increased decentering (p=0.029) and decreased amount (p=0.032) and duration of preoccupation (p=0.016) in the PSYRATS-D. For the feelings and motivations about close caring relationships of the MAP-SR, we observed a significant group x time interaction (p=0.027). The frequency of VR sickness was high but its severity was mild. There were significant differences only in HR over time in the VBM group (p=0.01). These results suggest that VBM was not more effective in reducing decentering and psychiatric symptoms than VR control but its adversity was modest. | Lee, Bo Mi; Kim, Sung-Wan; Lee, Bong Ju; Won, Seung-Hee; Park, Yong-han; Kang, Chae Yeong; Li, Ling; Rami, Fatima Zahra; Chung, Young-Chul | Jeonbuk Natl Univ, Dept Psychiat, Med Sch, Jeonju 54907, South Korea; Jeonbuk Natl Univ, Biomed Res Inst, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Jeonju 54907, South Korea; Chonnam Natl Univ, Dept Psychiat, Med Sch, Gwangju 501746, South Korea; Inje Univ, Coll Med, Haeundae Paik Hosp, Dept Psychiat, Busan 48108, South Korea; Kyungpook Natl Univ, Dept Psychiat, Sch Med, Daegu 41944, South Korea; Parks Psychiat Clin, Jeju, South Korea | Chung, Young/AAB-8242-2022; Rami, Fatima/ABS-5222-2022; Lee, Jungmin/KHT-2438-2024 | 57352457900; 47962371200; 59053777300; 35278955600; 58575335700; 58037684600; 57232581000; 57231663300; 55712695800 | chungyc@jbnu.ac.kr; | SCHIZOPHRENIA | SCHIZOPHRENIA-UK | 2754-6993 | 9 | 1 | SCIE | PSYCHIATRY | 2023 | 3 | 33.9 | 1.16 | 2025-06-25 | 5 | 6 | SELF-REPORT MEASURE; PERSECUTORY DELUSIONS; TRAINING-PROGRAM; SCHIZOPHRENIA; SCALE; HALLUCINATIONS; COMPASSION; DISORDERS; VALIDITY; PEOPLE | chlorpromazine; neuroleptic agent; adult; Article; auditory hallucination; Beck Depression Inventory; cybersickness; DSM-IV; female; heart rate; human; major clinical study; male; mindfulness; motivation; physiological stress; pilot study; pleasure; Positive and Negative Syndrome Scale; psychosis; questionnaire; randomized controlled trial; rating scale; RR interval; safety; schizophrenia spectrum disorder; skin conductance; virtual reality | English | 2023 | 2023-09-13 | 10.1038/s41537-023-00391-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Britanin inhibits titanium wear particle-induced osteolysis and osteoclastogenesis | Wear particle-induced osteolysis is a serious complication that occurs in individuals with titanium (Ti)-based implants following long-term usage due to loosening of the implants. The control of excessive osteoclast differentiation and inflammation is essential for protecting against wear particle-induced osteolysis. The present study evaluated the effect of britanin, a pseudoguaianolide sesquiterpene isolated from Inula japonica, on osteoclastogenesis in vitro and Ti particle-induced osteolysis in vivo. The effect of britanin was examined in the osteoclastogenesis of mouse bone marrow-derived macrophages (BMMs) using TRAP staining, RT-PCR, western blotting and immunocytochemistry. The protective effect of britanin was examined in a mouse calvarial osteolysis model and evaluated using micro-CT and histomorphometry. Britanin inhibited osteoclast differentiation and F-actin ring formation in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor kB ligand in BMMs. The expression of osteoclast-specific marker genes, including tartrate-resistant acid phosphatase, cathepsin K, dendritic cell-specific transmembrane protein, matrix metallopeptidase 9 and nuclear factor of activated T-cells cytoplasmic 1, in the BMMs was significantly reduced by britanin. In addition, britanin reduced the expression of B lymphocyte-induced maturation protein-1, which is a transcriptional repressor of negative osteoclastogenesis regulators, including interferon regulatory factor-8 and B-cell lymphoma 6. Conversely, britanin increased the expression levels of anti-oxidative stress genes, namely nuclear factor erythroid-2-related factor 2, NAD(P)H quinone oxidoreductase 1 and heme oxygenase 1 in the BMMs. Furthermore, the administration of britanin significantly reduced osteolysis in a Ti particle-induced calvarial osteolysis mouse model. Based on these findings, it is suggested that britanin may be a potential therapeutic agent for wear particle-induced osteolysis and osteoclast-associated disease. | Kim, Ju Ang; Lim, Soomin; Ihn, Hye Jung; Kim, Jung-Eun; Yea, Kyungmoo; Moon, Jimin; Choi, Hyukjae; Park, Eui Kyun | Kyungpook Natl Univ, Inst Hard Tissue & Biotooth Regenerat, Sch Dent, Dept Oral Pathol & Regenerat Med, Daegu 41940, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Dept New Biol, Daegu 42988, South Korea; Yeungnam Univ, Res Inst Cell Culture, Coll Pharm, Gyongsan 38541, Gyeongbuk, South Korea; Yeungnam Univ, Res Inst Cell Culture, Coll Pharm, 280 Daehak Ro, Gyongsan 38541, Gyeongbuk, South Korea; Kyungpook Natl Univ, Inst Hard Tissue & Biotooth Regenerat, Sch Dent, Dept oral Pathol & Regenerat Med, 2177 Dalgubeol Daero, Daegu 41940, South Korea | Kim, Ju Ang/LWI-0914-2024 | 55991948000; 57202647759; 56421724400; 57209054588; 12769131100; 57273609200; 7404339587; 37071072400 | h5choi@yu.ac;epark@knu.ac;h5choi@yu.ac.kr;epark@knu.ac.kr; | MOLECULAR MEDICINE REPORTS | MOL MED REP | 1791-2997 | 1791-3004 | 28 | 5 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL;ONCOLOGY | 2023 | 3.4 | 34.0 | 0.14 | 2025-06-25 | 2 | 1 | britanin; osteoclast; osteolysis; titanium particles; B lymphocyte-induced maturation protein-1; nuclear factor of activated T-cells; cytoplasmic 1 | KAPPA-B; OXIDATIVE STRESS; DIFFERENTIATION; RANKL; ACTIVATION; NRF2; INFLAMMATION; MACROPHAGES; EXPRESSION; REGULATORS | B lymphocyte‑induced maturation protein‑1; britanin; cytoplasmic 1; nuclear factor of activated T‑cells; osteoclast; osteolysis; titanium particles | Actin Cytoskeleton; Animals; Disease Models, Animal; Humans; Mice; Osteoclasts; Osteogenesis; Osteolysis; Titanium; acid phosphatase tartrate resistant isoenzyme; B lymphocyte induced maturation protein 1; britanin; cathepsin K; colony stimulating factor; F actin; gelatinase B; heme oxygenase 1; interferon consensus sequence binding protein; messenger RNA; osteoclast differentiation factor; protein bcl 6; reduced nicotinamide adenine dinucleotide (phosphate) dehydrogenase (quinone); sesquiterpene derivative; titanium; transcription factor MafB; transcription factor NFAT; transcription factor Nrf2; tumor necrosis factor; tumor necrosis factor receptor associated factor 6; unclassified drug; titanium; animal cell; animal experiment; animal model; animal tissue; Article; bone atrophy; bone marrow derived macrophage; calvaria; cell differentiation; controlled study; dendritic cell; drug mechanism; gene expression; gene expression level; genetic transcription; immunocytochemistry; in vitro study; in vivo study; inflammation; male; marker gene; micro-computed tomography; morphometry; mouse; mRNA expression level; nonhuman; osteoclast; osteoclastogenesis; oxidative stress; prosthesis loosening; protein expression; real time polymerase chain reaction; Western blotting; actin filament; animal; bone development; disease model; drug therapy; etiology; human; osteolysis | English | 2023 | 2023-11 | 10.3892/mmr.2023.13092 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Mastectomy with Reconstruction Including Robotic Endoscopic Surgery (MARRES): a prospective cohort study of the Korea Robot-Endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG) and Korean Breast Cancer Study Group (KBCSG) | BackgroundRobotic nipple-sparing mastectomy (RNSM) has emerged as a new treatment option for breast cancer and risk-reducing mastectomy (RRM) for women who have a high risk of pathogenic variants. Even though several studies have reported that RNSM is a feasible procedure, some argue that it should only be performed by specialized surgeons, and data on oncologic outcomes and patient-reported outcomes (PROs) are limited. Recently, the United States Food and Drug Administration and several surgeons warned that robotic breast surgery should be performed only by specialized surgeons and recommended that the benefits, risks, and alternatives of all available treatment options be discussed with patients so they can make informed treatment decisions. The Korea Robot-Endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG) has been established to evaluate, standardize, and teach this state-of-the-art procedure. We have designed a multicenter prospective cohort study entitled Mastectomy with Reconstruction Including Robot Endoscopic Surgery (MARRES) to report surgical, PRO, and oncologic outcomes.MethodsMARRES is a multi-institution cohort study prospectively collecting data from patients undergoing mastectomy and reconstruction. The patient inclusion criteria are adult women older than 19 with breast cancer or a high risk of breast cancer (patients with BRCA1/2, TP53, PALB2 mutations, etc.), who have scheduled therapeutic or RRM and want immediate reconstruction. Surgical outcomes, including pre- and postoperative photos, oncologic outcomes, cost-effectiveness, and PRO, are collected. The primary endpoints are postoperative complication rates within 30 postoperative days and the Clavien-Dindo grade of postoperative complications within 180 postoperative days. The secondary endpoints are 5-year postoperative recurrence-free survival and cancer incidence rate (for those who underwent RRM), patient satisfaction with reconstruction expectations preoperative (baseline) and results within 6 to 12 postoperative months, surgeon satisfaction with postoperative results in 6 postoperative months, and cost-effectiveness of the definitive surgery. Patient recruitment will be completed in April 2025, and the target number of enrolled patients is 2000.DiscussionThis study will provide evidence about the surgical outcomes, oncologic outcomes, and patient satisfaction with RNSM and endoscopic nipple-sparing mastectomy (NSM), compared with conventional NSM. | Ryu, Jai Min; Lee, Jeea; Lee, Jeeyeon; Ko, BeomSeok; Kim, Joo Heung; Shin, Hyukjai; Park, Hyung Seok | Sungkyunkwan Univ, Samsung Med Ctr, Dept Surg, Sch Med,Div Breast Surg, Seoul, South Korea; Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Surg, Seongnam, Gyeonggi Do, South Korea; Yonsei Univ, Grad Sch Med, Coll Med, Dept Surg, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Dept Surg, Seoul, South Korea; Yonsei Univ, Yongin Severance Hosp, Dept Surg, Coll Med, Yongin, Gyeonggi, South Korea; Hanyang Univ, Med Ctr, Myongji Hosp, Dept Surg, Goyang, South Korea; Yonsei Univ, Dept Surg, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea | Park, Hong-Gyu/C-6000-2008; Kim, Hyun/D-5568-2011 | 57158270000; 57211367316; 37079213100; 56781006300; 57190684229; 35187876700; 57226054304 | imgenius@yuhs.ac; | BMC CANCER | BMC CANCER | 1471-2407 | 23 | 1 | SCIE | ONCOLOGY | 2023 | 3.4 | 34.0 | 1.29 | 2025-06-25 | 14 | 10 | Breast neoplasms; Conventional nipple-sparing mastectomy; Endoscopic nipple-sparing mastectomy; Germline BRCA1; 2 mutation; Robotic-assisted nipple-sparing mastectomy; Minimally invasive procedure; Immediate breast reconstruction | NIPPLE-SPARING MASTECTOMY; ASSISTED SUBCUTANEOUS MASTECTOMY; EXTENDED FOLLOW-UP; IMMEDIATE RECONSTRUCTION; ONCOLOGICAL SAFETY; AREOLA COMPLEX; SKIN; FEASIBILITY; REDUCTION | Breast neoplasms; Conventional nipple-sparing mastectomy; Endoscopic nipple-sparing mastectomy; Germline BRCA1/2 mutation; Immediate breast reconstruction; Minimally invasive procedure; Robotic-assisted nipple-sparing mastectomy | Adult; BRCA1 Protein; BRCA2 Protein; Breast Neoplasms; Cohort Studies; Endoscopy; Female; Humans; Mammaplasty; Mastectomy; Nipples; Prospective Studies; Republic of Korea; Retrospective Studies; Robotic Surgical Procedures; Robotics; BRCA1 protein; BRCA1 protein, human; BRCA2 protein; BRCA2 protein, human; adult; Article; breast cancer; breast reconstruction; cancer incidence; cancer risk; cancer survival; clinical practice; cohort analysis; cost effectiveness analysis; endoscopic surgery; evidence based medicine; female; gene mutation; human; major clinical study; mastectomy; multicenter study; nipple-sparing mastectomy; outcome assessment; overall survival; PALB2 gene; patient satisfaction; patient-reported outcome; postoperative complication; postoperative period; practice guideline; preoperative period; prospective study; recurrence free survival; robot assisted surgery; TP53 gene; tumor gene; tumor suppressor gene; breast tumor; clinical trial; endoscopy; epidemiology; genetics; mastectomy; nipple; pathology; procedures; retrospective study; robotics; South Korea; surgery | English | 2023 | 2023-06-21 | 10.1186/s12885-023-10978-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Preoperative sequential short-course radiation therapy and FOLFOX chemotherapy versus long-course chemoradiotherapy for locally advanced rectal cancer: a multicenter, randomized controlled trial (SOLAR trial) | BackgroundPreoperative (chemo)radiotherapy has been widely used as an effective treatment for locally advanced rectal cancer (LARC), leading to a significant reduction in pelvic recurrence rates. Because early administration of intensive chemotherapy for LARC has more advantages than adjuvant chemotherapy, total neoadjuvant therapy (TNT) has been introduced and evaluated to determine whether it can improve tumor response or treatment outcomes. This study aims to investigate whether short-course radiotherapy (SCRT) followed by intensive chemotherapy improves oncologic outcomes compared with traditional preoperative long-course chemoradiotherapy (CRT).MethodsA multicenter randomized phase II trial involving 364 patients with LARC (cT3-4, cN+, or presence of extramural vascular invasion) will be conducted. Patients will be randomly assigned to the experimental or control arm at a ratio of 1:1. Participants in the experimental arm will receive SCRT (25 Gy in 5 fractions, daily) followed by four cycles of FOLFOX (oxaliplatin, 5-fluorouracil, and folinic acid) as a neoadjuvant treatment, and those in the control arm will receive conventional radiotherapy (45-50.4 Gy in 25-28 fractions, 5 times a week) concurrently with capecitabine or 5-fluorouracil. As a mandatory surgical procedure, total mesorectal excision will be performed 2-5 weeks from the last cycle of chemotherapy in the experimental arm and 6-8 weeks after the last day of radiotherapy in the control arm. The primary endpoint is 3-year disease-free survival, and the secondary endpoints are tumor response, overall survival, toxicities, quality of life, and cost-effectiveness.DiscussionThis is the first Korean randomized controlled study comparing SCRT-based TNT with traditional preoperative LC-CRT for LARC. The involvement of experienced colorectal surgeons ensures high-quality surgical resection. SCRT followed by FOLFOX chemotherapy is expected to improve disease-free survival compared with CRT, with potential advantages in tumor response, quality of life, and cost-effectiveness.Trial registrationThis trial is registered at Clinical Research Information under the identifier Service KCT0004874 on April 02, 2020, and at Clinicaltrial.gov under the identifier NCT05673772 on January 06, 2023. | Kang, Min Kyu; Park, Soo Yeun; Park, Jun Seok; Kim, Hye Jin; Kim, Jong Gwang; Kang, Byung Woog; Baek, Jin Ho; Cho, Seung Hyun; Seo, An Na; Kim, Duck-Woo; Kim, Jin; Baek, Se Jin; Kim, Ji Hoon; Kim, Ji Yeon; Ha, Gi Won; Park, Eun Jung; Park, In Ja; Kim, Chang Hyun; Kang, Hyun; Choi, Gyu-Seog | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiat Oncol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Colorectal Canc Ctr, Sch Med, 807 Hogukro, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Oncol Hematol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Surg, Seongnam, South Korea; Korea Univ, Dept Surg, Div Colon & Rectal Surg, Coll Med, Seoul, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Dept Surg, Div Colorectal Surg, Incheon, South Korea; Chungnam Natl Univ Hosp, Dept Surg, Div Colorectal Surg, Daejeon, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Biomed Res Inst, Res Inst Clin Med, Jeonju, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Surg, Div Colon & Rectal Surg,Coll Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Surg, Div Colon & Rectal Surg,Coll Med, Seoul, South Korea; Chonnam Natl Univ, Med Sch, Dept Surg, Hwasun Hosp, Hwasun, South Korea; Chung Ang Univ, Coll Med, Dept Anesthesiol & Pain Med, Seoul, South Korea | Park, Joonhong/AAZ-9885-2020; Kim, Sung-Bae/JXL-8219-2024; Kim, Hye/W-1059-2019; Kim, Jee/J-5441-2012; Ha, Gi/W-2026-2019; Kim, Chang Gon/IAP-6721-2023; Park, In/U-2371-2019; Baek, Se-Jin/Q-5450-2016; Park, Eun-Jung/GVT-6113-2022; Kim, Ji-Hoon/HZJ-6703-2023 | 57201933342; 40561578300; 35226761100; 57204567554; 59501049300; 28567838500; 57217075847; 55686242700; 55804153700; 35368632500; 55720304300; 55268770100; 57191681453; 56893070300; 56562681000; 56072952500; 7403243464; 57214805950; 36126616500; 8058759100 | kyuschoi@knu.ac.kr; | BMC CANCER | BMC CANCER | 1471-2407 | 23 | 1 | SCIE | ONCOLOGY | 2023 | 3.4 | 34.0 | 0.14 | 2025-06-25 | 2 | 1 | Rectal neoplasm; Neoadjuvant radiotherapy; Short-course radiation; Consolidation chemotherapy; Disease-free survival; Randomized controlled phase II trial; Protocol | SHORT-COURSE RADIOTHERAPY; TOTAL MESORECTAL EXCISION; OPEN-LABEL; CONSOLIDATION CHEMOTHERAPY; ADJUVANT CHEMOTHERAPY; COURSE CHEMORADIATION; PHASE-3; OXALIPLATIN; SURGERY | Consolidation chemotherapy; Disease-free survival; Neoadjuvant radiotherapy; Protocol; Randomized controlled phase II trial; Rectal neoplasm; Short-course radiation | Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Fluorouracil; Humans; Neoadjuvant Therapy; Neoplasm Staging; Quality of Life; Rectal Neoplasms; capecitabine; fluorouracil; folinic acid; oxaliplatin; antineoplastic agent; fluorouracil; adult; advanced cancer; Article; cancer survival; chemoradiotherapy; consolidation chemotherapy; controlled study; conventional radiotherapy; cost effectiveness analysis; disease free survival; female; human; major clinical study; male; multicenter study; neoadjuvant therapy; overall survival; phase 2 clinical trial; preoperative treatment; prospective study; quality of life; randomized controlled trial; rectum cancer; rectum tumor; short-course radiotherapy; tertiary care center; cancer staging; chemoradiotherapy; clinical trial; neoadjuvant therapy; procedures; rectum tumor | English | 2023 | 2023-11-03 | 10.1186/s12885-023-11363-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Safety and Effectiveness of Etanercept Biosimilar SB4 for Rheumatic Diseases in South Korea: Real-World Post-marketing Surveillance Data | IntroductionSB4 is the first approved biosimilar of etanercept, a biologic tumor necrosis factor inhibitor, to treat various autoimmune diseases including axial spondylarthritis (axSpA), rheumatoid arthritis (RA), psoriatic arthritis (PsA), and plaque psoriasis (PsO). This post-marketing surveillance (PMS) study of SB4 investigated safety and effectiveness in routine clinical practice and is part of the drug approval process in Korea. MethodsThis prospective, multi-center, open-label, observational, phase IV PMS study was designed to enroll patients with axSpA, RA, PsA, and PsO in Korea from September 2015 to September 2019. Both etanercept-naive patients or patients switched from reference etanercept were included. SB4 was administered weekly via subcutaneous injections using pre-filled syringes. Safety was assessed by the incidence of adverse events (AEs), adverse drug reactions (ADRs) and serious adverse events (SAE). Effectiveness was assessed by the change from baseline of investigator-rated Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in patients with ankylosing spondylitis (AS) and disease activity score-28 (DAS28) in patients with RA. ResultsAmong 316 enrolled patients, 314 were included in the safety analysis (176 with AS and 138 with RA). The overall incidence of AEs, ADRs and serious AEs were 17.8, 9.9, and 1.3%, respectively. Most AEs were mild (66.7%) or moderate (31.1%) and not related to SB4 (58.9%). Most common AEs were injection site pruritus (1.9%) and injection site rash (1.3%). At week 24, mean disease activity scores significantly decreased compared to baseline in naive patients with AS and RA (BASDAI 2.7 vs. 6.2, p < 0.0001; DAS28 3.8 vs. 5.7, p < 0.0001) and in switched patients with AS and RA (BASDAI 1.0 vs. 1.3, p = 0.0018; DAS28 2.4 vs. 2.9, p = 0.0893). ConclusionThis first real-world evidence of SB4 from a phase IV PMS study in Korea shows comparable effectiveness to historical SB4 real-world evidence without any new significant safety signals. | Yoo, Wan-Hee; Kang, Young Mo; Kim, Dong Wook; Kang, Eun Ha; Lee, Yeon-Ah; Suh, Chang-Hee; Sung, Yoon-Kyoung; Lee, Sang-Hoon; Gu, Dong-Ha; Lee, Jiwon; Choe, Jung-Yoon | Jeonbuk Natl Univ, Div Rheumatol, Dept Internal Med, Med Sch, Jeonju, South Korea; Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Jeonju, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Rheumatol, Daegu, South Korea; Inje Univ, Busan Paik Hosp, Busan, South Korea; Seoul Natl Univ, Div Rheumatol, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Kyung Hee Univ Hosp, Dept Internal Med, Div Rheumatol, Seoul, South Korea; Ajou Univ, Dept Rheumatol, Sch Med, Suwon, South Korea; Hanyang Univ Hosp Rheumat Dis, Dept Rheumatol, Seoul, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Dept Rheumatol, Seoul, South Korea; Samsung Bioepis, Incheon, South Korea; Daegu Catholic Univ, Div Rheumatol, Dept Internal Med, Sch Med, 33 Duryugongwon Ro 17 Gil, Daegu, South Korea | Lee, Sang-Hoon/ABH-6210-2020; Kim, Dong/I-7600-2015; Li, Shaofu/O-2241-2019 | 7102197467; 26221798000; 57201849481; 35484436800; 8536477700; 56188447500; 15754508900; 57218359658; 58000513100; 57999419500; 7201513769 | jychoe@cu.ac.kr; | RHEUMATOLOGY AND THERAPY | RHEUMATOL THER | 2198-6576 | 2198-6584 | 10 | 2 | SCIE | RHEUMATOLOGY | 2023 | 2.9 | 34.2 | 0.52 | 2025-06-25 | 3 | 3 | SB4; Etanercept; Biosimilar; Post-marketing surveillance; Real-world evidence; Safety; Effectiveness; Ankylosing spondylitis; Rheumatoid arthritis | ARTHRITIS; PATIENT | Ankylosing spondylitis; Biosimilar; Effectiveness; Etanercept; Post-marketing surveillance; Real-world evidence; Rheumatoid arthritis; Safety; SB4 | etanercept; adult; aged; ankylosing spondylitis; arthralgia; Article; axial spondyloarthritis; Bath ankylosing spondylitis disease activity index; clinical practice; connective tissue disease; controlled clinical trial; controlled study; DAS28; dizziness; drug approval; drug efficacy; drug safety; female; gastrointestinal disease; human; incidence; infection; infestation; injection site contusion; injection site erythema; injection site pain; injection site pruritus; injection site rash; injection site reaction; injection site swelling; major clinical study; male; middle aged; multicenter study; nausea; neurologic disease; observational study; phase 4 clinical trial; pneumonia; postmarketing surveillance; psoriasis vulgaris; psoriatic arthritis; rheumatic disease; rheumatoid arthritis; South Korea; synovitis; tenosynovitis; very elderly; young adult | English | 2023 | 2023-04 | 10.1007/s40744-022-00515-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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