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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article No Synergistic Effect of Silibinin and Morin in a Kainic Acid-Induced Epileptic Mouse Model Temporal lobe epilepsy (TLE) is the most common form of localization-related epilepsy, with the highest prevalence rate in adulthood. Recently, we reported the beneficial effects of the individual treatment with flavonoids such as silibinin and morin in kainic acid (KA)-treated mouse model for TLE. In this study, we investigated whether there is a synergistic effect of co-treatment with silibinin and morin on the susceptibility to seizure, the frequency of spontaneous recurrent seizures (SRSs), and granule cell dispersion in the dentate gyrus, which could be partially controlled by treatment with each flavonoid in the animal model for TLE. Unfortunately, we did not observe any synergistic effect against the susceptibility of seizure and SRS induced by KA treatment. However, the combination of these flavonoids showed similar antiepileptic effects compared with treatment with each one individually. Therefore, although silibinin and morin are not suitable for combination therapy, our results still suggest that these flavonoids can be used as potent therapeutic compounds for preventing epileptic seizures. Hong, Jungwan; Lee, Ji Min; Yoon, Dongyeong; Jung, Un Ju; Kim, Sang Ryong Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Food Sci & Nutr, Busan, South Korea Lee, Ji Min/KCZ-2783-2024 57196247899; 58607005600; 57214744587; 7007119425; 56486163800 srk75@knu.ac.kr; JOURNAL OF MEDICINAL FOOD J MED FOOD 1096-620X 1557-7600 23 2 SCIE CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS 2020 2.786 47.9 0 2025-06-25 0 0 combined treatment; epilepsy; granule cell dispersion; morin; silibinin GRANULE CELL DISPERSION; FLAVONOIDS; NEUROTOXICITY combined treatment; epilepsy; granule cell dispersion; morin; silibinin Animals; Dentate Gyrus; Drug Synergism; Epilepsy, Temporal Lobe; Flavonoids; Kainic Acid; Mice; Seizures; Silybin; kainic acid; morin; silibinin; flavonoid; kainic acid; morin; silibinin; animal cell; animal experiment; anticonvulsant activity; Article; controlled study; dentate gyrus; dispersion; drug effect; drug potentiation; epileptic state; granule cell; hippocampus; in vivo study; intrahippocampal drug administration; kainic acid-induced seizure; mouse; mouse model; nonhuman; post hoc analysis; priority journal; seizure susceptibility; synergistic effect; temporal lobe epilepsy; animal; cytology; drug potentiation; seizure; temporal lobe epilepsy English 2020 2020-02-01 10.1089/jmf.2019.4522 바로가기 바로가기 바로가기 바로가기
Article Physalis alkekengi Exhibits Antiobesity Effects in Mice with Potential of Inducing White Adipose Tissue Browning The aim of this study was to investigate the efficacy of an ethanol extract of Physalis alkekengi (PA) and its mechanistic pathway of action at the molecular level for its antiobesity properties. Four-week old male Institute of Cancer Research (ICR) mice were acclimatized for a week before starting the high-fat diet (HFD) for 2 weeks to induce obesity, followed by 8 more weeks of oral administration of 10 mg/kg orlistat and 300 mg/kg of PA extract, along with HFD. Body weights of the mice and feed and water intake were recorded weekly. After a total of 12 weeks, mice were euthanized, and blood, liver, and adipose tissues were harvested for further analysis. Administration of PA extract inhibited the progression of obesity by reducing weight gain, weight of adipose tissue, and normalizing serum triglyceride, glucose, total cholesterol, high-density lipoprotein, low-density lipoprotein, alanine aminotransferase, and aspartate aminotransferase. PA extract prevented the progression of nonalcoholic steatohepatitis induced by HFD and prevented the enlargement of liver. Phosphorylation of adenosine monophosphate-activated protein kinase alpha increased while phosphorylation of acetyl-CoA carboxylase was reduced. The browning gene uncoupling protein 1 expression was also increased by PA extract treatment. Our findings revealed that the antiobesity properties of PA extract may be mediated by browning of white adipose tissue. Lee, Yuan Yee; Kim, Minki; Irfan, Muhammad; Kim, Seung-Hyung; Kim, Sung-Dae; Rhee, Man Hee Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu 41566, South Korea; Daejeon Univ, Inst Tradit Med & Biosci, Daejeon, South Korea; Dongnam Inst Radiol & Med Sci, Res Ctr, Busan 46033, South Korea Yuan Yee, Lee/ABH-8956-2022; Irfan, Muhammad/AAY-1961-2021; Kim, Seung-Hyung/AAA-4707-2020; Rhee, Man/O-5705-2016 57203798815; 57199747297; 35069404400; 54383305300; 55156746000; 57211035357 sdkim@dirams.re.kr;rheemh@knu.ac.kr; JOURNAL OF MEDICINAL FOOD J MED FOOD 1096-620X 1557-7600 23 3 SCIE CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS 2020 2.786 47.9 0.46 2025-06-25 5 6 antiobesity; browning gene; high-fat diet; Physalis alkekengi; UCP-1 FRANCHETII MAST. MAKINO; VAR.-FRANCHETII; POLYSACCHARIDE; INFLAMMATION antiobesity; browning gene; high-fat diet; Physalis alkekengi; UCP-1 Acetyl-CoA Carboxylase; Adipose Tissue, Brown; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Diet, High-Fat; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Obesity; Physalis; Plant Extracts; Uncoupling Protein 1; 2 ( 4 methoxyphenyl) 1,3 dioxolane; 2,3 dihydro 3,5 dihydroxy 6 methyl 4h pyran 4 one; 5 hydroxymethylfurfural; acetyl coenzyme A carboxylase; adenosine monophosphate activated protein kinase alpha; alanine aminotransferase; alcohol; antiobesity agent; aspartate aminotransferase; cholesterol; ethanol extract of Physalis alkekengi; glucose; high density lipoprotein; hydroxymethylglutaryl coenzyme A reductase kinase; linoleic acid; low density lipoprotein; n hexadecanoic acid; octanoic acid; oleic acid; plant extract; plant medicinal product; quinic acid; tetrahydrolipstatin; triacylglycerol; unclassified drug; uncoupling protein 1; water; acetyl coenzyme A carboxylase; antiobesity agent; hydroxymethylglutaryl coenzyme A reductase kinase; plant extract; uncoupling protein 1; alanine aminotransferase blood level; animal euthanasia; animal experiment; animal tissue; antiobesity activity; Article; aspartate aminotransferase blood level; blood sampling; body weight; body weight gain; body weight loss; brown adipose tissue; cholesterol blood level; controlled study; diet-induced obesity; drug efficacy; drug identification; epididymis fat; feeding; fluid intake; gene expression; glucose blood level; high-fat diet-induced steatohepatitis; in vivo study; lipid diet; liver tissue; male; mass fragmentography; mouse; nonhuman; Physalis alkekengi; priority journal; protein phosphorylation; receptor upregulation; total cholesterol level; treatment duration; triacylglycerol blood level; white adipose tissue; adverse event; animal; brown adipose tissue; C57BL mouse; chemistry; drug effect; genetics; human; Institute for Cancer Research mouse; metabolism; obesity; Physalis; white adipose tissue English 2020 2020-03-01 10.1089/jmf.2019.4625 바로가기 바로가기 바로가기 바로가기
Article Does the new Korean term for epilepsy reduce the stigma for Korean adults with epilepsy? Purpose: The purpose of this study was to evaluate differences in stigma, disclosure management of epilepsy, and knowledge about epilepsy between patients with epilepsy who recognized and did not recognize the new Korean term for epilepsy. Methods: This was a cross-sectional, multicenter study. The Stigma Scale-Revised, the Disclosure Management Scale, the Patient Health Questionnaire-9, and a questionnaire assessing knowledge about epilepsy were used. The set of questionnaires had two versions, using either the old or new name for epilepsy. Multivariate logistic regression analyses were used. Results: A total of 341 patients with epilepsy and 509 family members were recruited. Approximately 62% of patients felt some degree of epilepsy-related stigma. Mild stigma, severe concealment of epilepsy diagnosis, and increased knowledge about epilepsy were independently identified as factors associated with recognition of the new term in patients. Recognition of the new term was more prevalent in patients and family members with higher education, female family members, and family members having patients with younger age at seizure onset and shorter duration of epilepsy. There were no significant differences between the two types of questionnaires. About 81% of patients and 93% of family members had a positive attitude about renaming epilepsy. Conclusion: The use of the new Korean term for epilepsy (cerebroelectric disorder) increased knowledge about epilepsy but did not reduce stigma and concealment of epilepsy diagnosis in Korean adults with epilepsy. Higher education may be an important factor for knowing the new term in patients and family members. (C) 2019 Elsevier Inc. All rights reserved. Lee, Sang-Ahm; Han, Su-Hyun; Cho, Yang-Je; Kim, Keun Tae; Kim, Ji-Eun; Shin, Dong Jin; Seo, Jong-Geun; Kim, Young-Soo; Ryu, Han Uk; Lee, Seo-Young; Kim, Jung Bin; Kang, Kyung-Wook; Kim, Shinhye; Kwon, Soonhak; Kim, Joonsik; Kim, Sunjun; Kim, Hyo Jeong; Eun, So-Hee; Hur, Yun Jung; Choi, Sun Ah; Yum, Mi-Sun; Park, Soyoung; Kim, Jee Hyun; Lee, Gha Hyun; Kim, Young Mi; Hwang, Kyoung Jin; Kim, Eun Young; Yeon, Gyu Min Univ Ulsan, Asan Med Ctr, Dept Neurol & Pediat, Coll Med, Seoul, South Korea; Chung Ang Univ, Dept Neurol, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Neurol, Coll Med, Seoul, South Korea; Keimyung Univ, Dept Neurol & Pediat, Dongsan Hosp, Daegu, South Korea; Daegu Catholic Univ, Dept Neurol, Med Ctr, Daegu, South Korea; Gachon Univ, Dept Neurol & Pediat, Gil Med Ctr, Incheon, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol & Pediat, Daegu, South Korea; Gyeongsang Natl Univ, Dept Neurol, Changwon Hosp, Chang Won, South Korea; Chonbuk Natl Univ Hosp, Dept Neurol & Pediat, Jeonju, South Korea; Kangwon Natl Univ Hosp, Dept Neurol, Chunchon, South Korea; Korea Univ, Dept Neurol, Anam Hosp, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Neurol, Kwangju, South Korea; Myongji Univ Hosp, Dept Pediat, Goyang, South Korea; Korea Univ, Dept Pediat, Ansan Hosp, Ansan, South Korea; Inje Univ, Dept Pediat, Haeundae Paik Hosp, Pusan, South Korea; Bundang Seoul Natl Univ Hosp, Dept Pediat, Bundang, South Korea; Soonchunhyang Univ, Dept Pediat, Bucheon Hosp, Bucheon, South Korea; Dankook Univ Hosp, Dept Neurol, Cheonan, South Korea; Pusan Natl Univ Hosp, Dept Neurol & Pediat, Pusan, South Korea; Kyung Hee Univ, Dept Neurol, Med Ctr, Seoul, South Korea; Kwangju Christian Hosp, Dept Pediat, Kwangju, South Korea; Pusan Natl Univ, Dept Pediat, Yangsan Hosp, Yangsan, South Korea ; Kim, Keun Tae/IQU-1105-2023; Kang, Kyung Wook/AGG-1331-2022; Lee, Gha-hyun/HHN-8692-2022; Kim, YoungHwan/B-2395-2013; Hwang, Chisang/AAO-4665-2021; Lee, Yoojin/AAB-9799-2022; Lee, Dong/J-2778-2012; Kim, Jee Hyun/LCE-2449-2024 57190211641; 12784871800; 8731005700; 57204465615; 55720222600; 59502750400; 16040307500; 57061234200; 56516063800; 35262340000; 53264153700; 57211333312; 57196226150; 55468232200; 37106957600; 57193955312; 58365452900; 39761441100; 36637334200; 57191539101; 21735652500; 57194328105; 55932113900; 37661749600; 57207443147; 56357078600; 57072097200; 57190847675 salee@amc.seoul.kr; EPILEPSY & BEHAVIOR EPILEPSY BEHAV 1525-5050 1525-5069 102 SCIE BEHAVIORAL SCIENCES;CLINICAL NEUROLOGY;PSYCHIATRY 2020 2.937 48.1 0.33 2025-06-25 6 5 Epilepsy; Renaming epilepsy; Stigma; Disclosure of epilepsy diagnosis; Knowledge about epilepsy; Depression KNOWLEDGE; CLASSIFICATION; SCHIZOPHRENIA; ATTITUDES; PEOPLE; NAME Depression; Disclosure of epilepsy diagnosis; Epilepsy; Knowledge about epilepsy; Renaming epilepsy; Stigma Adult; Cross-Sectional Studies; Epilepsy; Female; Health Knowledge, Attitudes, Practice; Humans; Male; Middle Aged; Republic of Korea; Social Stigma; Terminology as Topic; adult; aged; Article; controlled study; cross-sectional study; demography; Disclosure Management Scale; disease duration; DSM-IV; epilepsy; female; human; major clinical study; male; medical education; multicenter study; Patient Health Questionnaire 9; prevalence; questionnaire; scoring system; self report; South Korea; Stigma Scale Revised; attitude to health; clinical trial; ethnology; middle aged; nomenclature; social stigma English 2020 2020-01 10.1016/j.yebeh.2019.106719 바로가기 바로가기 바로가기 바로가기
Article Factors associated with stigma and depressive symptoms in family members of patients with epilepsy Purpose: Literature regarding family stigma related to epilepsy is scarce. This study investigated the prevalence of family stigma and depressive symptoms and the associated factors among the family members of patients with epilepsy. Methods: In a cross-sectional study, Stigma Scale-Revised score >= 4 and Patient Health Questionnaire-9 score >= 10 were considered indicative of moderate-to-severe stigma and depressive symptoms, respectively. Stepwise logistic regression analyses were performed. Results: Of the 482 family members, a mean age was 47.1 +/- 9.4 years, and 73.4% were female. Of the patients, a mean age was 25.5 +/- 16.7 years, and 45.0% were female. Idiopathic generalized epilepsy and focal epilepsy were noted in 22.4% and 65.6% of patients, respectively. Family stigma and depressive symptoms were noted in 10.0% and 11.2% of family members, respectively. Family stigma was significantly associated with high seizure frequency and being a sibling or offspring of a patient independent of their depressive symptoms. By contrast, depressive symptoms in family members were significantly associated with polytherapy, being parents of a patient, and neurological comorbidities independent of family stigma. In a subset of patients and their family, patients had higher proportion of stigma and depressive symptoms than their family. Depressive symptoms and stigma among patients were significantly correlated with those among parents, but not spouse. Conclusion: Family stigma is common in families with epilepsy and is closely related to depressive symptoms. Frequent seizures, polytherapy, neurological comorbidities, and the relationship to a patient may be factors that are independently associated with family stigma and depressive symptoms in family members. (c) 2020 Elsevier Inc. All rights reserved. Lee, Sang-Ahm; Han, Su-Hyun; Cho, Yang-Je; Kim, Keun Tae; Kim, Ji-Eun; Shin, Dong Jin; Seo, Jong-Geun; Kim, Young-Soo; Ryu, Han Uk; Lee, Seo-Young; Kim, Jung Bin; Kang, Kyung-Wook; Kim, Shinhye; Kwon, Soonhak; Kim, Joonsik; Kim, Sunjun; Kim, Hyo Jeong; Eun, So-Hee; Hur, Yun Jung; Choi, Sun Ah; Yum, Mi-Sun; Park, Soyoung; Kim, Jee Hyun; Lee, Gha Hyun; Kim, Young Mi; Hwang, Kyoung Jin; Kim, Eun Young; Yeon, Gyu Min Univ Ulsan, Dept Neurol & Pediat, Asan Med Ctr, Coll Med, Seoul, South Korea; Chung Ang Univ, Dept Neurol, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Neurol, Coll Med, Seoul, South Korea; Keimyung Univ, Dept Neurol & Pediat, Coll Med, Daegu, South Korea; Daegu Catholic Univ, Dept Neurol, Sch Med, Daegu, South Korea; Gachon Univ Med & Sci, Dept Neurol & Pediat, Incheon, South Korea; Kyungpook Natl Univ, Dept Neurol & Pediat, Sch Med, Daegu, South Korea; Gyeongsang Natl Univ, Sch Med, Dept Neurol, Changwon Hosp, Chang Won, South Korea; Chonbuk Natl Univ, Dept Neurol & Pediat, Sch Med, Jeonju, South Korea; Kangwon Natl Univ, Dept Neurol, Sch Med, Chunchon, South Korea; Korea Univ, Dept Neurol, Coll Med, Seoul, South Korea; Chonnam Natl Univ, Dept Neurol, Sch Med, Kwangju, South Korea; Myongji Hosp, Dept Pediat, Goyang, South Korea; Korea Univ, Coll Med, Dept Pediat, Ansan Hosp, Ansan, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Pediat, Coll Med, Pusan, South Korea; Seoul Natl Univ, Coll Med, Dept Pediat, Bundang Hosp, Bundang, South Korea; Soonchunhyang Univ, Coll Med, Dept Pediat, Bucheon Hosp, Bucheon, South Korea; Dankook Univ, Dept Neurol, Coll Med, Cheonan, South Korea; Pusan Natl Univ, Dept Neurol & Pediat, Sch Med, Pusan, South Korea; Kyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea; Kwangju Christian Hosp, Dept Pediat, Kwangju, South Korea; Pusan Natl Univ, Sch Med, Dept Pediat, Yangsan Hosp, Yangsan, South Korea Lee, Dong/J-2778-2012; Kim, Keun Tae/IQU-1105-2023; Lee, Yoojin/AAB-9799-2022; Lee, Gha-hyun/HHN-8692-2022; Kim, YoungHwan/B-2395-2013; Kim, Jee Hyun/LCE-2449-2024; Kang, Kyung Wook/AGG-1331-2022 57190211641; 12784871800; 8731005700; 57204465615; 55720222600; 59502750400; 16040307500; 57061234200; 56516063800; 35262340000; 53264153700; 57211333312; 57196226150; 55468232200; 37106957600; 57193955312; 58365452900; 39761441100; 36637334200; 57191539101; 21735652500; 57194328105; 55932113900; 37661749600; 57207443147; 56357078600; 57072097200; 57190847675 salee@amc.seoul.kr; EPILEPSY & BEHAVIOR EPILEPSY BEHAV 1525-5050 1525-5069 110 SCIE BEHAVIORAL SCIENCES;CLINICAL NEUROLOGY;PSYCHIATRY 2020 2.937 48.1 0.41 2025-06-25 12 12 Epilepsy; Stigma; Family; Depression; Polytherapy; Antiepileptic drug KOREAN ADOLESCENTS; PERCEIVED STIGMA; AFFILIATE STIGMA; ILAE COMMISSION; POSITION PAPER; CHILDREN; CLASSIFICATION; PERCEPTION; SEVERITY; MOTHERS Antiepileptic drug; Depression; Epilepsy; Family; Polytherapy; Stigma Adolescent; Adult; Child; Cross-Sectional Studies; Depression; Epilepsy; Family; Female; Humans; Male; Middle Aged; Self Report; Social Stigma; Young Adult; anticonvulsive agent; adult; Article; comorbidity; controlled study; cross-sectional study; depression; epilepsy; family; female; focal epilepsy; generalized epilepsy; human; major clinical study; male; middle aged; parent; Patient Health Questionnaire 9; prevalence; progeny; rating scale; sibling; spouse; stigma; Stigma Scale Revised; adolescent; child; depression; epilepsy; family; psychology; self report; social stigma; young adult English 2020 2020-09 10.1016/j.yebeh.2020.107129 바로가기 바로가기 바로가기 바로가기
Article Treatment of epilepsy in adults: Expert opinion in South Korea Objective: The aim of this study was to gather the expert opinions of Korean epileptologists regarding the treatment of adult patients with epilepsy. Methods: A total of 42 neurologists who specialized in epilepsy were surveyed. They completed an online questionnaire describing multiple patient scenarios. Using these scenarios, they evaluated treatment strategies and gave their preference for specific antiepileptic drugs (AEDs) used to treat genetically mediated generalized epilepsy and focal epilepsy. Results: Initial AED monotherapy, followed by a second form of alternative monotherapy or an add-on combination therapy, was the preferred treatment strategy. The experts reached consensus for 87.2% of the items. The most commonly selected AEDs for the initial monotherapy for patients with generalized epilepsy were levetiracetam or valproate. For those with focal epilepsy, levetiracetam,oxcarbazepine, or lamotrigine were the most popular selections. Ethosuximide was the treatment of choice only for patients with generalized epilepsy with prominent absence seizures. Levetiracetam was preferred as an add-on therapy for both generalized and focal epilepsy. For special populations of patients, such as elderly adults or those with comorbid diseases, levetiracetam or lamotrigine was selected as the treatment of choice. Conclusion: Most of the survey results were in accordance with the US expert opinion survey published in 2016. This survey can assist clinicians in making clinical decisions when treating individual adult patients with epilepsy. (C) 2020 Elsevier Inc. All rights reserved. Byun, Jung-Ick; Kim, Dong Wook; Kim, Keun Tae; Yang, Kwang Ik; Lee, Soon-Tae; Seo, Jong-Geun; No, Young Joo; Kang, Kyung Wook; Kim, Daeyoung; Kim, Jae Moon; Cho, Yong Won Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Sch Med, Dept Neurol, Seoul, South Korea; Konkuk Univ, Dept Neurol, Sch Med, Seoul, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurol, Sch Med, Daegu, South Korea; Soonchunhyang Univ, Cheonan Hosp, Dept Neurol, Coll Med, Cheonan, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Samsung Noble Cty, Yongin, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Neurol, Sch Med, Gwangju, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Neurol, Sch Med, Daejeon, South Korea Kim, Keun Tae/IQU-1105-2023; Lee, Sang/J-5578-2012 55896913500; 57075285300; 57204465615; 55328263200; 8527655300; 16040307500; 6701791454; 57211333312; 57191361218; 34769781900; 55080335000 neurocho@dsmc.or.kr; EPILEPSY & BEHAVIOR EPILEPSY BEHAV 1525-5050 1525-5069 105 SCIE BEHAVIORAL SCIENCES;CLINICAL NEUROLOGY;PSYCHIATRY 2020 2.937 48.1 0.82 2025-06-25 11 11 Consensus; Treatment; Generalized epilepsy; Focal epilepsy; Antiepileptic drug ANTIEPILEPTIC DRUGS; TREATED EPILEPSY; THERAPY; LAMOTRIGINE; TOPIRAMATE; PREVALENCE; MANAGEMENT; TUMORS; SANAD; BRAIN Antiepileptic drug; Consensus; Focal epilepsy; Generalized epilepsy; Treatment Adult; Aged; Anticonvulsants; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Generalized; Expert Testimony; Female; Humans; Lamotrigine; Levetiracetam; Male; Middle Aged; Oxcarbazepine; Republic of Korea; Surveys and Questionnaires; Treatment Outcome; Valproic Acid; Young Adult; anticonvulsive agent; ethosuximide; lamotrigine; levetiracetam; oxcarbazepine; valproic acid; adult; Article; comorbidity; consensus; epilepsy; epileptologist; female; focal epilepsy; generalized epilepsy; health care survey; human; male; medical expert; monotherapy; neurologist; online analysis; questionnaire; South Korea; absence; aged; expert witness; focal epilepsy; generalized epilepsy; middle aged; procedures; questionnaire; treatment outcome; young adult English 2020 2020-04 10.1016/j.yebeh.2020.106942 바로가기 바로가기 바로가기 바로가기
Article Dual antiplatelet therapy beyond 12 months versus for 12 months after drug-eluting stents for acute myocardial infarction Background: The optimal duration of dual antiplatelet therapy (DAPT) after acute coronary syndrome remains uncertain. This study investigated the benefit of DAPT beyond 12 months after drug-eluting stents (DES) for acute myocardial infarction (MI). Methods: From Korea Acute Myocardial Infarction Registry-National Institute of Health database, 6199 patients treated with DAPT for 12 months after DES (second-generation DES 98%) without ischemic or bleeding events were analyzed. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE), a composite of death from any cause, MI, or ischemic stroke during the period from 12 to 24 months. Results: After adjustment using inverse probability of treatment weighting, patients who received DAPT beyond 12 months (n = 4795), compared to patients treated with 12-month DAPT (n = 1404), had a similar incidence of MACCE (1.3% vs. 1.0%, HR: 1.32, 95% CI: 0.71-2.45, p = 0.378). The 2 groups did not differ significantly in the rates of death (0.1% vs. 0.1%), MI (0.8% vs.0.6%), stent thrombosis (0.1% vs. 0.2%), ischemic stroke (0.4% vs. 0.2%), and major bleeding (0.1% vs. 0.1%). The rate of net adverse clinical events was 1.4% with DAPT beyond 12 months and 1.1% with 12-month DAPT (p = 0.466). Conclusions: DAPT beyond 12 months, as compared with 12-month DAPT, in real-world patients with acute MI treated predominantly with second-generation DES did not reduce the risk of MACCE. The rates of major bleeding and net adverse clinical events did not differ significantly between the 2 treatments. (C) 2019 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. Sim, Doo Sun; Jeong, Myung Ho; Kim, Hyo Soo; Gwon, Hyeon Cheol; Seung, Ki Bae; Rha, Seung Woon; Chae, Shung Chull; Kim, Chong Jin; Cha, Kwang Soo; Park, Jong Seon; Yoon, Jung Han; Chae, Jei Keon; Joo, Seung Jae; Choi, Dong Ju; Hur, Seung Ho; Seong, In Whan; Cho, Myeong Chan; Kim, Doo Il; Oh, Seok Kyu; Ahn, Tae Hoon; Hwang, Jin Yong Chonnam Natl Univ Hosp, Gwanjgu, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Sungkyunkwan Univ, Seoul Samsung Med Ctr, Seoul, South Korea; Catholic Univ Korea, Seoul, South Korea; Korea Univ, Guro Hosp, Seoul, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea; Kyung Hee Univ Hosp Gangdong, Seoul, South Korea; Pusan Natl Univ Hosp, Busan, South Korea; Yeungnam Univ Hosp, Daegu, South Korea; Yonsei Univ, Wonju Severance Christian Hosp, Wonju Coll Med, Wonju, South Korea; Chunbuk Natl Univ Hosp, Jeonju, South Korea; Jeju Natl Univ Hosp, Jeju, South Korea; Seoul Natl Univ, Bundang Hosp, Seongnam, South Korea; Keimyung Univ, Dongsan Med Ctr, Daegu, South Korea; Chungnam Natl Univ Hosp, Daejeon, South Korea; Chungbuk Natl Univ Hosp, Cheongju, South Korea; Inje Univ, Haeundae Paik Hosp, Busan, South Korea; Wonkwang Univ Hosp, Iksan, South Korea; Gachon Univ, Gil Med Ctr, Incheon, South Korea; Kyungsang Natl Univ Hosp, Jinju, South Korea Choi, Dong-Ju/J-5686-2012; Kim, Hyo/J-2753-2012; 안, 태훈/GON-9067-2022; Rha, Seung-Woon/AGE-5810-2022; Kim, Jin Sug/AAY-6890-2021; Han, Jae-Young/AAV-1100-2021; Jeong, Young-Hoon/F-3476-2015 7006825347; 56485157500; 33567809200; 6603262426; 7003964208; 8569030400; 7101962036; 35229511500; 7102837700; 15763054600; 35760728900; 26029709000; 9236504200; 35274349200; 34570274500; 35254371300; 7401727518; 8635545900; 24734336000; 57202554645; 55892914700 myungho@chollian.net; JOURNAL OF CARDIOLOGY J CARDIOL 0914-5087 1876-4738 75 1 SCIE CARDIAC & CARDIOVASCULAR SYSTEMS 2020 3.159 48.2 0.74 2025-06-25 10 9 Antiplatelet agents; Drug-eluting stents; Myocardial infarction IMPLANTATION; CLOPIDOGREL; DURATION; TRIAL; METAANALYSIS; VALIDATION; TICAGRELOR; EFFICACY; REGISTRY Antiplatelet agents; Drug-eluting stents; Myocardial infarction Acute Disease; Aged; Combined Modality Therapy; Drug-Eluting Stents; Female; Hemorrhage; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Aggregation Inhibitors; Time Factors; beta adrenergic receptor blocking agent; ticagrelor; antithrombocytic agent; acute coronary syndrome; acute heart infarction; adult; Article; bleeding; brain ischemia; cardiovascular disease; cerebrovascular disease; clinical outcome; dual antiplatelet therapy; female; heart left ventricle ejection fraction; hospitalization; human; major clinical study; male; risk benefit analysis; stent thrombosis; target vessel revascularization; treatment duration; acute disease; adverse device effect; aged; bleeding; clinical trial; drug eluting stent; heart infarction; middle aged; multicenter study; multimodality cancer therapy; time factor English 2020 2020-01 10.1016/j.jjcc.2019.06.006 바로가기 바로가기 바로가기 바로가기
Article Molecular Detection and Subtyping of Blastocystis Detected in Wild Boars (Sus scrofa) in South Korea Blastocystis is a genus of parasitic protozoans that live in humans, mammals, and birds and which has been widely studied due to its low host specificity. Limited data are available, however, regarding its presence in wildlife, particularly in South Korea. Contact between wild boars (Sus scrofa) and livestock or humans has steadily increased as wild boars venture down from the mountains to farms and residential areas. In this study, we examined the status and subtypes (STs) of Blastocystis in wild boars in South Korea and confirmed its zoonotic potential. From March 2016 to November 2018, we collected 433 fecal samples throughout the country from trapped or road-killed wild boars. The 18S rRNA gene was used for molecular identification and subtyping and the proportion of PCR-positive samples was 10.4%. We then assessed positive samples for associations with sex, region, and seasonal infection; however, no statistical significance was observed for any variable other than season. Phylogenetic analyses revealed that all sequences belonged to subtype 5 and had 99.5-99.9% identity with sequences obtained from Japanese cattle (Bos taurus) and 97.1% identity with sequences obtained from Chinese. Subtype 5 has been implicated in zoonoses, indicating that Korean wild boars could transmit Blastocystis to humans and other livestock. Our results, in accordance with the One Health concept, strongly support continued interest and efforts by public health and disease control organizations toward transmission prevention. Lee, Haeseung; Seo, Min-Goo; Oem, Jae-Ku; Kim, Young-Sik; Lee, Sook-Young; Kim, Jisoo; Jeong, Hyesung; Jheong, Weon-Hwa; Kim, Yongkwan; Lee, Won-Jae; Kwon, Oh-Deog; Kwak, Dongmi Kyungpook Natl Univ, Coll Vet Med, 80 Daehak Ro, Daegu 41566, South Korea; Jeonbuk Natl Univ, Coll Vet Med, 79 Gobong Ro, Iksan 54596, Jeonbuk, South Korea; Natl Inst Environm Res, Environm Hlth Res Dept, 42 Hwangyeong Ro, Incheon 22689, South Korea Kim, Yong-kwan/LIC-0165-2024; Seo, Min-Goo/NQF-4335-2025 57202497862; 53982155300; 6506283913; 57214047069; 54410896200; 57193128565; 57213935791; 24076289900; 57193715617; 57205486455; 7402195886; 7007148758 dmkwak@knu.ac.kr; JOURNAL OF WILDLIFE DISEASES J WILDLIFE DIS 0090-3558 1943-3700 56 3 SCIE VETERINARY SCIENCES 2020 1.535 48.3 1.11 2025-06-25 16 16 Blastocystis; phylogenetic analysis; South Korea; wild boar GENETIC DIVERSITY; HUMANS; LIVESTOCK; PROVINCE; PIGS Blastocystis; Phylogenetic analy-sis; South Korea; Wild boar Animals; Blastocystis; Blastocystis Infections; Feces; Female; Male; Phylogeny; Republic of Korea; Sus scrofa; Swine; Swine Diseases; animal; Blastocystis; blastocystosis; classification; feces; female; genetics; male; parasitology; phylogeny; pig; South Korea; swine disease; veterinary medicine English 2020 2020-07 10.7589/2019-04-092 바로가기 바로가기 바로가기 바로가기
Article Picture Fuzzy Ideals of Near-Rings A picture fuzzy set (PFS) is an augmentation of Atanassov's intuitionistic fuzzy set (IFS). The PFS-based models are useful in the circumstances when we face uncertain and vague information, especially in the case when we need more answers of the form "indeed," "avoid," "no," and "refusal." It has been considered as an essential tool to deal with unsure data during an investigation. In this manuscript, we explore the idea of a picture fuzzy near-ring (PFNR) and a picture fuzzy ideal (PFI) of a near-ring (NR). We illustrate some basic properties such as union, intersection, homomorphic image, and preimage of PFIs of a NR. Furthermore, there is discussion about the direct product of PFIs of a NR. Asif, Awais; Aydi, Hassen; Arshad, Muhammad; Rehman, Abdul; Tariq, Usman Int Islamic Univ, Dept Math & Stats, Islamabad, Pakistan; Ton Duc Thang Univ, Nonlinear Anal Res Grp, Ho Chi Minh City, Vietnam; Ton Duc Thang Univ, Fac Math & Stat, Ho Chi Minh City, Vietnam; Univ Sousse, Inst Super Informat & Tech Commun, Hammam Sousse 4000, Tunisia; China Med Univ, China Med Univ Hosp, Taichung 40402, Taiwan; Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu 41566, South Korea; Nankai Univ, Dept Comp Sci, Tianjin 300071, Peoples R China Arshad, Muhammad/MAH-8073-2025; Rehman, Abdul/D-5630-2019; Aydi, Hassen/A-3577-2015; aydi, hassen/A-3577-2015 59302346900; 23093040500; 59284144300; 57200894071; 57221311044 hassen.aydi@tdtu.edu.vn; JOURNAL OF MATHEMATICS J MATH-UK 2314-4629 2314-4785 2020 SCIE MATHEMATICS 2020 0.971 48.3 0.92 2025-06-25 2 5 English 2020 2020-12-24 10.1155/2020/8857459 바로가기 바로가기 바로가기 바로가기
Article Effect ofHelicobacter pyloriinfection and its eradication on gastric regenerating atypia in 22 133 subjects Background and Aim The aim of this study was to identify factors affecting persistent gastric regenerating atypia and determine the effect ofHelicobacter pylorieradication on the course of this lesion. Methods In cross-sectional setting, comprehensive health check-up subjects who underwent both endoscopy andH. pyloritest from 2001 to 2009 were included. The association betweenH. pyloriand gastric regenerating atypia was evaluated. In cohort setting, patients with regenerating atypia who underwentH. pyloritest from 2001 to 2013 were included. Factors affecting positive pathology (persistent regenerating atypia or new development of neoplasm) in patients with regenerating atypia at baseline were investigated. Results In cross-sectional setting, regenerating atypia was observed in 1.1% (241/22 133).H. pyloriinfection was associated with gastric regenerating atypia (adjusted odds ratio, 1.47; 95% confidence interval [CI], 1.12-1.91). In cohort setting, 310 patients with regenerating atypia were finally eligible. Positive pathology rate during follow up was 16.1% (15/93) in the persistent infection group, 2.8% (3/106) in successful eradication group, and 4.5% (5/111) in baselineH. pylori-negative group. PersistentH. pyloriinfection increased the risk of positive pathology (adjusted risk ratio [RR], 7.18; 95% CI, 1.95-26.48) compared toH. pylorieradication group. PersistentH. pyloriinfection increased the risk of regenerative atypia (adjusted RR, 5.70; 95% CI, 1.46-22.17) and new neoplasm (adjusted RR, 10.74; 95% CI, 1.10-105.17) compared to baseline negativeH. pylori. Conclusions H. pyloriinfection is an independent risk factor for gastric regenerating atypia. Eradication ofH. pyloriseems helpful for regression of regenerating atypia. Nam, Ji Hyung; Nam, Su Youn; Park, Bum Joon; Ryu, Kum Hei Natl Canc Ctr, Ctr Canc Prevent & Detect, Dept Internal Med, Goyang, South Korea; Dongguk Univ, Ilsan Hosp, Dept Internal Med, Coll Med, Goyang, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Ctr Gastr Canc, Sch Med,Chilgok Hosp, Daegu, South Korea 42361607200; 55617028500; 57205135306; 8129408900 nam20131114@gmail.com; JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY J GASTROEN HEPATOL 0815-9319 1440-1746 35 9 SCIE GASTROENTEROLOGY & HEPATOLOGY 2020 4.029 48.4 0 2025-06-25 0 0 H; pylorieradication; Helicobacter pylori; regenerating atypia EXPRESSION; DYSPLASIA; THERAPY; MUCOSA H. pylori eradication; Helicobacter pylori; regenerating atypia Cohort Studies; Cross-Sectional Studies; Female; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Stomach Neoplasms; Stomach Ulcer; amoxicillin; bismuth; clarithromycin; omeprazole; adult; alcohol consumption; Article; body mass; cohort analysis; controlled study; cross-sectional study; current smoker; disease eradication; esophagogastroduodenoscopy; female; follow up; Helicobacter infection; Helicobacter pylori; human; major clinical study; male; middle aged; persistent infection; priority journal; retrospective study; smoking; complication; Helicobacter infection; pathology; stomach mucosa; stomach tumor; stomach ulcer English 2020 2020-09 10.1111/jgh.15016 바로가기 바로가기 바로가기 바로가기
Article Nationwide validation study of diagnostic algorithms for inflammatory bowel disease in Korean National Health Insurance Service database Background and Aim We conducted a nationwide validation study of diagnostic algorithms to identify cases of inflammatory bowel disease (IBD) within the Korea National Health Insurance System (NHIS) database. Method Using the NHIS dataset, we developed 44 algorithms combining the International Classification of Diseases (ICD)-10 codes, codes for Rare and Intractable Diseases (RID) registration and claims data for health care encounters, and pharmaceutical prescriptions for IBD-specific drugs. For each algorithm, we compared the case identification results from electronic medical records data with the gold standard (chart-based diagnosis). A multiple sampling test verified the validation results from the entire study population. Results A random nationwide sample of 1697 patients (848 potential cases and 849 negative control cases) from 17 hospitals were included for validation. A combination of the ICD-10 code, >= 1 claims for health care encounters, and >= 1 prescription claims (reference algorithm) achieved excellent performance (sensitivity, 93.1% [95% confidence interval 91-94.7]; specificity, 98.1% [96.9-98.8]; positive predictive value, 97.5% [96.1-98.5]; negative predictive value, 94.5% [92.8-95.8]) with the lowest error rate (4.2% [3.3-5.3]). The multiple sampling test confirmed that the reference algorithm achieves the best performance regarding IBD diagnosis. Algorithms including the RID registration codes exhibited poorer performance compared with that of the reference algorithm, particularly for the diagnosis of patients affiliated with secondary hospitals. The performance of the reference algorithm showed no statistical difference depending on the hospital volume or IBD type, with P-value < 0.05. Conclusions We strongly recommend the reference algorithm as a uniform standard operational definition for future studies using the NHIS database. Lee, Chang Kyun; Ha, Hyo Jung; Oh, Shin Ju; Kim, Jung-Wook; Lee, Jung Kuk; Kim, Hyun-Soo; Yoon, Soon Man; Kang, Sang-Bum; Kim, Eun Soo; Kim, Tae Oh; Na, Soo-Young; Lee, Jun; Kim, Sang-Wook; Koo, Hoon Sup; Park, Byung Kyu; Lee, Han Hee; Kim, Eun Sun; Park, Jae Jun; Kwak, Min Seob; Cha, Jae Myung; Ye, Byong Duk; Choi, Chang Hwan; Kim, Hyo Jong Kyung Hee Univ, Coll Med, Dept Gastroenterol, Ctr Crohns & Colitis, 23 Kyungheedae Ro, Seoul 02447, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul, South Korea; Korea Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyung Hee Univ, Coll Med, Kyung Hee Univ Gang Dong, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Ulsan, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Inflammatory Bowel Dis Ctr, Ulsan, South Korea; Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Chungbuk Natl Univ, Coll Med, Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Dept Internal Med, Daejeon, South Korea; Konyang Univ, Dept Internal Med, Coll Med, Daejeon, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Inje Univ, Coll Med, Haeundae Paik Hosp, Dept Internal Med, Busan, South Korea; Jeju Natl Univ, Dept Internal Med, Sch Med, Jeju, South Korea; Chosun Univ, Dept Internal Med, Coll Med, Gwangju, South Korea; Chonbuk Natl Univ, Dept Internal Med, Med Sch, Jeonju, South Korea; Natl Hlth Insurance Serv Ilsan Hosp, Dept Internal Med, Goyang, South Korea; Yonsei Univ, Wonju Coll Med, Dept Biostat, Wonju, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea ; Kim, Jung-Wook/AAI-1668-2020; Park, Jaejun/MVW-1869-2025; Cheon, Jung-Eun/J-5684-2012; Kim, Chang/G-5001-2015; Ye, Byong/AAF-4955-2020; Kim, Sara/F-2951-2013; Lee, Chang/AAI-1012-2020; Lee, Han Hee/AAB-7987-2022; Kwak, Sang Gyu/AAG-4341-2021; KIM, SEON-OK/HGC-7012-2022; Kim, Hyung/J-5451-2012; Lee, Jun/AAC-6941-2022; Kim, Sang/J-5398-2012 26434331200; 57211626946; 57197763164; 55862677700; 57207929604; 55739553100; 9734821400; 8837205700; 57203086704; 57189056554; 55682497900; 57202953059; 57215329002; 36523211900; 56295944800; 57192499711; 56308204100; 14120150500; 56982549400; 57203991065; 14069472300; 55741566200; 55363170800 changkyun.lee@khu.ac.kr; JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY J GASTROEN HEPATOL 0815-9319 1440-1746 35 5 SCIE GASTROENTEROLOGY & HEPATOLOGY 2020 4.029 48.4 1.73 2025-06-25 50 50 administrative claims; health care; diagnostic algorithm; inflammatory bowel disease; operational definition ADMINISTRATIVE DATA; CROHNS-DISEASE; SOUTH-KOREA; ULCERATIVE-COLITIS; CANCER-RISK; CARE COSTS; ONTARIO; ADULTS administrative claims, health care; diagnostic algorithm; inflammatory bowel disease; operational definition Algorithms; Databases, Factual; Humans; Inflammatory Bowel Diseases; International Classification of Diseases; National Health Programs; Predictive Value of Tests; Rare Diseases; Registries; Republic of Korea; adalimumab; azathioprine; infliximab; mercaptopurine; mesalazine; methotrexate; adult; algorithm; Article; controlled study; Crohn disease; diagnostic accuracy; electronic medical record; female; gold standard; health care; hospital volume; human; ICD-10; inflammatory bowel disease; major clinical study; male; national health insurance; predictive value; prescription; priority journal; secondary care center; sensitivity and specificity; ulcerative colitis; validation study; young adult; factual database; inflammatory bowel disease; International Classification of Diseases; public health; rare disease; register; South Korea English 2020 2020-05 10.1111/jgh.14855 바로가기 바로가기 바로가기 바로가기
Article A Study of NaI(Tl) crystal encapsulation using organic scintillators for the dark matter search Scintillating NaI(Tl) crystals are used for various rare decay experiments, such as dark matter searches. However, the hygroscopicity of NaI(Tl) crystals makes the construction of crystal detectors in these experiments challenging. Therefore, the crystal requires a tight encapsulation to prevent from air contact. More importantly, in a low radioactivity measurement, identification of external radiations and surface contamination is crucial to characterize the origin of total crystal radioactivities. Studies for the NaI(Tl) crystal encapsulation with active organic scintillator vetoes have been performed to mitigate the above-mentioned issues simultaneously. A bare crystal is directly coupled with liquid and plastic scintillators to tag external radiations that penetrate from the outer part of the crystal. We report the pulse shape discrimination between organic scintillator and the crystal scintillator in a single detector setup and their long-term stability. Lee, J. Y.; Adhikari, G.; Ha, C.; Kim, H. J.; Kim, N. Y.; Kim, S. K.; Kim, Y. D.; Lee, H. S. Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Sejong Univ, Dept Phys, Seoul 05006, South Korea; Inst for Basic Sci Korea, Ctr Underground Phys, Daejeon 34126, South Korea; Seoul Natl Univ, Dept Phys & Astron, Seoul 08826, South Korea Lee, Jooyoung/HTN-0335-2023; Kim, Hong Joo/AAE-1178-2022; KIM, Sun Kee/IQT-8178-2023; Ha, Chang Hyon/AAR-8120-2021 57204797944; 56811058500; 17342119700; 59051568100; 55263267200; 59102407800; 7410207253; 23477682800 changhyon.ha@gmail.com; NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT NUCL INSTRUM METH A 0168-9002 1872-9576 953 SCIE INSTRUMENTS & INSTRUMENTATION;NUCLEAR SCIENCE & TECHNOLOGY;PHYSICS, NUCLEAR;PHYSICS, PARTICLES & FIELDS 2020 1.455 48.5 0.34 2025-06-25 6 7 NaI(Tl); Organic scintillator; Dark matter; Phoswich SODIUM Dark matter; NaI(Tl); Organic scintillator; Phoswich Dark Matter; Galaxies; Ionization; Radiation; Radioactivity; Radioactivity measurement; Sodium Iodide; Crystal scintillators; Dark matter searches; NaI(Tl); Organic scintillator; Phoswich; Plastic scintillator; Pulse shape discrimination; Surface contaminations; Scintillation counters English 2020 2020-02-11 10.1016/j.nima.2019.163141 바로가기 바로가기 바로가기 바로가기
Article Beam background study for the Belle II Silicon Vertex Detector The Belle II experiment aims to accumulate 50 ab(-1) of e(+)e(-) collision data at the SuperKEKB asymmetric energy collider (Tsukuba, Japan). The first physics data using all Belle II detectors were taken in spring 2019. In the vast physics program of the Belle II experiment, the vertex detector plays a crucial role for the determination of the B-meson decay vertices. It consists of two inner layers of pixelated silicon detectors and four outer layers of double-sided silicon strip detectors (SVD). To achieve a design luminosity of 8 x 10(35) cm(-2)s(-1), 40 times higher than the recorded luminosity of its predecessor, the SuperKEKB collider squeezes the beams to a vertical size of 50 nm ("nano-beam scheme") and doubles the beam currents. Therefore, the detectors are required to tolerate intense beam induced background due to the very high luminosity. During the 2019 spring run we measured the occupancy rate in the SVD to estimate the level of the beam induced background. With the low initial luminosity, the observed beam induced background mostly originated from Touschek processes and beam-gas scattering within individual beams. Since these different background contributions depend differently on accelerator conditions, such as the beam current, beam size and pressure, they can be disentangled. We estimate the background rate of each contribution and compare them with simulated ones. The results enable us to predict the background levels at increased beam currents and luminosity in the coming years. They also hint at background mitigation measures for running at higher luminosity. In this proceeding we present the results of our study of the beam induced background in the SVD and the prospects for future operation. Tanigawa, H.; Adamczyk, K.; Aihara, H.; Aziz, T.; Bacher, S.; Bahinipati, S.; Batignani, G.; Baudot, J.; Behera, P. K.; Bettarini, S.; Bilka, T.; Bozek, A.; Buchsteiner, F.; Casarosa, G.; Cervenkov, D.; Chen, Y. Q.; Corona, L.; Czank, T.; Das, S. B.; Dash, N.; de Marino, G.; Dolezal, Z.; Dujany, G.; Forti, F.; Friedl, M.; Ganiev, E.; Gobbo, B.; Halder, S.; Hara, K.; Hazra, S.; Higuchi, T.; Irmler, C.; Ishikawa, A.; Jeon, H. B.; Joo, C.; Kaleta, M.; Kaliyar, A. B.; Kandra, J.; Kang, K. H.; Kapusta, P.; Kodys, P.; Kohriki, T.; Kumar, M.; Kumar, R.; Kvasnicka, P.; La Licata, C.; Lalwani, K.; Lanceri, L.; Lee, S. C.; Li, Y. B.; Libby, J.; Lueck, T.; Maity, S.; Mayekar, S. N.; Mohanty, G. B.; Grimaldo, J. A. Mora; Morii, T.; Nakamura, K. R.; Nakayama, H.; Natkaniec, Z.; Onuki, Y.; Ostrowicz, W.; Paladino, A.; Paoloni, E.; Park, H.; Rao, K. K.; Ripp-Baudot, I.; Rizzo, G.; Rout, N.; Sahoo, D.; Santelj, L.; Sato, N.; Schwanda, C.; Suzuki, J.; Tanaka, S.; Thalmeier, R.; Tsuboyama, T.; Uematsu, Y.; Vahsen, S. E.; Verbycka, O.; Vitale, L.; Wan, K.; Watanuki, S.; Webb, J.; Wiechczynski, J.; Yin, H.; Zani, L.; Zhang, T. Univ Melbourne, Sch Phys, Melbourne, Vic 3010, Australia; Austrian Acad Sci, Inst High Energy Phys, A-1050 Vienna, Austria; Peking Univ, Dept Tech Phys, Beijing 100871, Peoples R China; Univ Sci & Technol China, Dept Modern Phys, Hefei 230026, Peoples R China; Charles Univ Prague, Fac Math & Phys, Prague 12116, Czech Republic; Univ Strasbourg, CNRS, IPHC, UMR 7178, F-67037 Strasbourg, France; Indian Inst Technol Bhubaneswar, Satya Nagar, India; Indian Inst Technol Madras, Chennai 600036, Tamil Nadu, India; Malaviya Natl Inst Technol Jaipur, Jaipur TATA INST F, Rajasthan, India; Punjab Agr Univ, Ludhiana 141004, Punjab, India; Tata Inst Fundamental Res, Mumbai 400005, Maharashtra, India; Univ Pisa, Dipartimento Fis, I-56127 Pisa, Italy; Ist Nazl Fis Nucl, Sez Pisa, I-56127 Pisa, Italy; Univ Trieste, Dipartimento Fis, I-34127 Trieste, Italy; INFN Sez Trieste, I-34127 Trieste, Italy; Grad Univ Adv Studies SOKENDAI, Hayama, Kanagawa 2400193, Japan; Univ Tokyo, Univ WPI, Kavli Inst Phys & Math, Kashiwa, Chiba 2778583, Japan; Tohoku Univ, Dept Phys, Sendai, Miyagi 9808578, Japan; Univ Tokyo, Dept Phys, Tokyo 1130033, Japan; High Energy Accelerator Res Org KEK, Tsukuba, Ibaraki 3050801, Japan; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; H Niewodniczanski Inst Nucl Phys, PL-31342 Krakow, Poland; Univ Hawaii, Dept Phys & Astron, 2505 Correa Rd, Honolulu, HI 96822 USA; Univ Ljubljana, Fac Math & Phys, Jadranska 19, SI-1000 Ljubljana, Slovenia; Ludwig Maximilian Univ Munich, D-80539 Munich, Germany ; Ostrowicz, Waclaw/Y-3938-2018; Pachariya, Manoj/A-9646-2016; Cervenkov, Daniel/D-2884-2017; Behera, Prafulla/AAK-8686-2020; OSTROWICZ, WACLAW/Y-3938-2018; Kumar, Rajender/JSL-0696-2023; bettarini, stefano/M-2502-2016; Chen, Ziqi/HPE-6145-2023; Bilka, Tadeáš/Q-3680-2017; Joo, Changwoo/ABI-4034-2020; Llácer, María/AAQ-7522-2020; Rizzo, Giuliana/A-8516-2015; Li, Jiarong/ABG-6750-2022; Bilka, Tadeas/Q-3680-2017; Adamczyk, Karol/W-2301-2018; Doležal, Zdeněk/K-6861-2017; Forti, Francesco/H-3035-2011; Kodys, Peter/P-2636-2017; ISHIKAWA, Akimasa/AAG-9668-2020; Aihara, Hiroaki/F-3854-2010; Natkaniec, Zbigniew/AAP-2995-2021 57203804357; 56448523500; 26431253400; 57198200847; 57014918700; 35226929900; 35226921900; 7003306478; 57943353600; 55116333600; 56624583600; 35226998700; 56446995000; 36169158700; 55913471500; 59817779600; 57209105515; 57028463700; 57202083225; 56985709800; 57216841951; 57214699347; 56200044200; 35227146800; 10044712100; 57215857442; 35227306900; 57209094410; 57205557485; 57222816542; 57224139534; 15069585600; 35227389900; 57014196800; 54398896700; 57203805096; 57193274163; 57015230400; 57224903543; 24329126300; 14826956800; 35227561100; 57221404520; 55553737220; 57093553100; 55759603000; 46661127500; 57211953490; 57257924100; 58754147400; 55820982400; 35086577400; 57220731521; 55949914700; 35227732200; 56582129000; 57014635700; 56394864900; 58825411600; 35227761700; 35227766800; 35227773600; 56572518100; 35227715200; 35086680500; 59633046200; 35227855600; 35227845800; 57213625981; 57215857178; 35590850800; 57216629640; 35228014600; 57222040123; 57232742000; 56447101400; 16020533400; 57216843679; 36154061900; 57216841841; 57198320699; 57195153044; 57014809700; 57014140800; 15835927600; 57013958200; 57195150092; 57216843658 tanigawa@hep.phys.s.u-tokyo.ac.jp; NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT NUCL INSTRUM METH A 0168-9002 1872-9576 982 SCIE INSTRUMENTS & INSTRUMENTATION;NUCLEAR SCIENCE & TECHNOLOGY;PHYSICS, NUCLEAR;PHYSICS, PARTICLES & FIELDS 2020 1.455 48.5 0.42 2025-06-25 5 5 Belle II; Silicon vertex detector; Beam background Beam background; Belle II; Silicon vertex detector High energy physics; Luminance; Petroleum prospecting; Springs (components); Asymmetric energy; Background level; Design luminosity; Double-sided silicon strip detectors; Mitigation measures; Physics programs; Silicon Vertex Detectors; Vertex detectors; Silicon detectors English 2020 2020-12-01 10.1016/j.nima.2020.164580 바로가기 바로가기 바로가기 바로가기
Article; Proceedings Paper Commissioning of the Belle II Silicon Vertex Detector The Belle II experiment at the SuperKEKB collider of KEK (Japan) will accumulate 50 ab(-1) of e(+)e(-) collision data at an unprecedented instantaneous luminosity of 8. 10(35) cm(-2)s(-1), about 40 times larger than its predecessor. The Belle II vertex detector plays a crucial role in the rich Belle II physics program, especially for timedependent measurements. It consists of two layers of DEPFET-based pixels and four layers of double sided silicon strip sensors (SVD detector). We report here results of the standalone commissioning of the SVD and highlights from the first cosmic runs acquired in Belle II. We also report on reconstruction performances of a reduced-scale version of the SVD operated during the accelerator commissioning in 2018. Casarosa, G.; Aihara, H.; Aziz, T.; Bacher, S.; Bahinipati, S.; Barberio, E.; Baroncelli, Ti.; Baroncelli, To.; Basith, A. K.; Batignani, G.; Bauer, A.; Behera, P. K.; Bertacchi, V.; Bettarini, S.; Bhuyan, B.; Bilka, T.; Bosi, F.; Bosisio, L.; Bozek, A.; Buchsteiner, F.; Caria, G.; Ceccanti, M.; Cervenkov, D.; Corona, L.; Czank, T.; Dash, N.; De Nuccio, M.; Dolezal, Z.; Forti, F.; Friedl, M.; Gobbo, B.; Grimaldo, J. A. M.; Halder, S.; Hara, K.; Higuchi, T.; Irmler, C.; Ishikawa, A.; Jeon, H. B.; Joo, C.; Kaleta, M.; Kandra, J.; Kang, K. H.; Kodys, P.; Kohriki, T.; Komarov, I.; Kumar, M.; Kumar, R.; Kvasnicka, P.; La Licata, C.; Lalwani, K.; Lanceri, L.; Lee, J. Y.; Lee, S. C.; Li, Y.; Libby, J.; Lueck, T.; Mammini, P.; Martini, A.; Mayekar, S. N.; Mohanty, G. B.; Morii, T.; Nakamura, K. R.; Natkaniec, Z.; Onuki, Y.; Ostrowicz, W.; Paladino, A.; Paoloni, E.; Park, H.; Prasanth, K.; Profeti, A.; Rao, K. K.; Rashevskaya, I.; Resmi, P. K.; Rizzo, G.; Rozanska, M.; Sahoo, D.; Sasaki, J.; Sato, N.; Schultschik, S.; Schwanda, C.; Stypula, J.; Suzuki, J.; Tanaka, S.; Tanigawa, H.; Taylor, G. N.; Thalmeier, R.; Tsuboyama, T.; Urquijo, P.; Vitale, L.; Wan, K.; Watanabe, M.; Watanuki, S.; Watson, I. J.; Webb, J.; Wiechczynski, J.; Williams, S.; Yin, H.; Zani, L. Univ Melbourne, Sch Phys, Melbourne, Vic 3010, Australia; Austrian Acad Sci, Inst High Energy Phys, Vienna, Austria; Peking Univ, Dept Tech Phys, Beijing 100871, Peoples R China; Charles Univ Prague, Fac Math & Phys, Prague 12116, Czech Republic; Indian Inst Technol, Bhubaneswar, Satya Nagar, India; Indian Inst Technol Madras, Chennai 600036, Tamil Nadu, India; Indian Inst Technol Guwahati, Gauhati 781039, Assam, India; Malaviya Natl Inst Technol Jaipur, Jaipur 302017, Rajasthan, India; Punjab Agr Univ, Ludhiana 141004, Punjab, India; Tata Inst Fundamental Res, Mumbai 400005, Maharashtra, India; Univ Pisa, Dipartimento Fis, I-56127 Pisa, Italy; INFN Sez Pisa, I-56127 Pisa, Italy; Univ Trieste, Dipartimento Fis, I-34127 Trieste, Italy; INFN Sez Trieste, I-34127 Trieste, Italy; Univ Tokyo, Kavli Inst Phys & Math Universe WPI, Kashiwa, Chiba 2778583, Japan; Niigata Univ, Dept Phys, Niigata 9502181, Japan; Tohoku Univ, Dept Phys, Sendai, Miyagi 9808578, Japan; Univ Tokyo, Dept Phys, Tokyo 1130033, Japan; High Energy Accelerator Res Org KEK, Tsukuba, Ibaraki 3050801, Japan; Kyungpook Natl Univ, Dept Phys, Daegu 702701, South Korea; Seoul Natl Univ, Dept Phys & Astron, Seoul 151742, South Korea; H Niewodniczanski Inst Nucl Phys, PL-31342 Krakow, Poland; TIFPA INFN, I-38123 Trento, Italy; Nippon Dent Univ, Niigata 9518580, Japan Bilka, Tadeas/Q-3680-2017; Rozanska, Maria/X-1840-2018; Lee, Jeeyun/I-7171-2015; KUMAR, RAJEEV/ADE-7638-2022; Li, Jiarong/ABG-6750-2022; Williams, Spencer/C-3545-2009; Bertacchi, Valerio/KFQ-6990-2024; Dash, Nibedita/ABA-4232-2021; bettarini, stefano/M-2502-2016; Joo, Changwoo/ABI-4034-2020; Doležal, Zdeněk/K-6861-2017; Park, Hae/AAM-2956-2021; Rozanska, Maria/ABG-6745-2020; ISHIKAWA, Akimasa/AAG-9668-2020; Rizzo, Giuliana/A-8516-2015; Natkaniec, Zbigniew/AAP-2995-2021; Ostrowicz, Waclaw/Y-3938-2018; Forti, Francesco/H-3035-2011; Behera, Prafulla/AAK-8686-2020; OSTROWICZ, WACLAW/Y-3938-2018; Higuchi, Takashi/C-4571-2017; Pachariya, Manoj/A-9646-2016; Barberio, Elisabetta/A-4978-2010; Kodys, Peter/P-2636-2017; Aihara, Hiroaki/F-3854-2010; Bilka, Tadeáš/Q-3680-2017; Komarov, Ivan/HRE-1390-2023; Cervenkov, Daniel/D-2884-2017; Llácer, María/AAQ-7522-2020; Watson, Ian/IAM-9344-2023 36169158700; 26431253400; 57198200847; 57014918700; 35226929900; 35775092300; 57195155294; 36016044400; 57195644350; 35226921900; 57196955631; 57943353600; 57203807394; 55116333600; 57830739900; 56624583600; 7004296450; 34767849000; 35226998700; 56446995000; 57197856101; 55009243100; 55913471500; 57209105515; 57028463700; 56985709800; 57203807007; 57214699347; 35227146800; 10044712100; 35227306900; 56582129000; 57209094410; 57205557485; 57224139534; 15069585600; 35227389900; 57014196800; 54398896700; 57203805096; 57015230400; 57224903543; 14826956800; 35227561100; 57203089210; 57221404520; 55553737220; 57093553100; 55759603000; 46661127500; 57211953490; 55870761600; 57257924100; 58754147400; 55820982400; 35086577400; 6701815309; 57204078384; 55949914700; 35227732200; 57014635700; 56394864900; 35227761700; 35227766800; 35227773600; 56572518100; 35227715200; 58642658300; 57215967699; 6701469333; 59633046200; 15844304700; 57200576462; 35227845800; 15751743800; 57215857178; 57014372000; 57216629640; 57015564500; 35228014600; 35086942200; 57222040123; 57232742000; 57203804357; 57203335500; 56447101400; 16020533400; 35228106200; 57198320699; 57195153044; 35228289800; 57014809700; 7102030607; 57014140800; 15835927600; 57214066113; 57013958200; 57195150092 giulia.casarosa@pi.infn.it; NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT NUCL INSTRUM METH A 0168-9002 1872-9576 958 SCIE INSTRUMENTS & INSTRUMENTATION;NUCLEAR SCIENCE & TECHNOLOGY;PHYSICS, NUCLEAR;PHYSICS, PARTICLES & FIELDS 2020 1.455 48.5 0 2025-06-25 0 0 Vertex detector; Strip detector; Commissioning Commissioning; Strip detector; Vertex detector Silicon; Commissioning; Physics programs; Reduced scale; Silicon strip sensor; Silicon Vertex Detectors; Strip detectors; Time dependent measurements; Vertex detectors; Cosmology English 2020 2020-04-01 10.1016/j.nima.2019.05.025 바로가기 바로가기 바로가기 바로가기
Article; Proceedings Paper Compact phonon-scintillation detection system for rare event searches at low temperatures We have developed a compact cryogenic measurement system to investigate the phonon and scintillation properties of various scintillating crystals. This system employs a 1 x 1 x 1 cm(3) crystal for the simultaneous detection of heat (phonon) and light (scintillation) signals based on metallic magnetic calorimeter (MMC) readouts at milliKelvin temperatures. Three molybdate crystals of CaMoO4, Na2Mo2O7, and Li2MoO4 were tested in the detector system. This work surveys scintillating crystals as target materials for neutrinoless double beta (0 nu beta beta) decay of Mo-100. All the measurements are successful in simultaneously detecting heat and light signals from the crystals. The measurements also results in clear particle identification using the pulse shapes and the relative amplitude ratios of the heat and light signals. We report the performance of the detector system through the amplitudes and time constants of the signals and the particle identification discrimination powers with discussion on 0 nu beta beta applications. Kim, H. L.; Jeon, J. A.; Kim, I.; Kim, S. R.; Kim, H. J.; Kim, Y. H.; Kwon, D. H.; Lee, M. K.; So, J. H. Inst for Basic Sci Korea, Ctr Underground Phys, Daejeon 34047, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Korea Res Inst Stand & Sci, Daejeon 34113, South Korea Kim, Hong Joo/AAE-1178-2022; Lee, Jinwoo/P-2493-2018; Lee, You/T-6086-2019; Kim, Inwook/AAI-5234-2020 57218825747; 24478376500; 55477709100; 56401942100; 59051568100; 57196171764; 57201795741; 7409120947; 35277558300 yhk@ibs.re.kr;jhso50@ibs.re.kr; NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT NUCL INSTRUM METH A 0168-9002 1872-9576 954 SCIE INSTRUMENTS & INSTRUMENTATION;NUCLEAR SCIENCE & TECHNOLOGY;PHYSICS, NUCLEAR;PHYSICS, PARTICLES & FIELDS 2020 1.455 48.5 0.41 2025-06-25 11 10 Low temperature detector; Scintillating crystal; Phonon-scintillation detection; Neutrinoless double beta decay DOUBLE-BETA DECAY; MAGNETIC CALORIMETER; THERMAL-PROPERTIES; LIGHT DETECTION; HEAT-CAPACITY; GROWTH Low temperature detector; Neutrinoless double beta decay; Phonon-scintillation detection; Scintillating crystal Calcium compounds; Crystals; Lithium compounds; Molybdenum compounds; Phonons; Scintillation; Sodium compounds; Temperature; Low temperature detector; Metallic magnetic calorimeters; Millikelvin temperatures; Neutrinoless double-beta decays; Scintillating crystals; Scintillation detection; Scintillation detection systems; Scintillation properties; Particle detectors English 2020 2020-02-21 10.1016/j.nima.2019.04.061 바로가기 바로가기 바로가기 바로가기
Article; Proceedings Paper Dual-readout calorimetry, an integrated high-resolution solution for energy measurements at future electron-positron colliders Future circular electron-positron colliders operating at root s = 90, 160, 240 and 350 GeV as Z, W, H and t factories will demand experiments with superior momentum and energy resolution for all the possible final-state particles produced. The IDEA Detector aims at satisfying these requests by exploiting an ultra-light drift chamber as the largest central tracker and a dual-readout fiber calorimeter for both electromagnetic and hadronic energy measurements. In this paper I review the dual-readout calorimeter baseline choices, as well as the related R&D work. Antonello, M.; Caccia, M.; Ferrari, R.; Franchino, S.; Gaudio, G.; Hauptman, J.; Lee, S.; Pezzotti, L.; Salvatore, F.; Santoro, R.; Vivarelli, I.; Wigmans, R. INFN, Milan, Italy; Univ Insubria, Como, Italy; INFN, Pavia, Italy; Heidelberg Univ, Kirchhoff Inst Phys, Heidelberg, Germany; Iowa State Univ, Ames, IA USA; Kyungpook Natl Univ, Daegu, South Korea; Univ Pavia, Pavia, Italy; Sussex Univ, Brighton, E Sussex, England; Texas Tech Univ, Lubbock, TX 79409 USA ; Antonello, Massimiliano/KIB-8239-2024; Caccia, Massimo/C-5407-2012; Pezzotti, Lorenzo/GRO-2971-2022; gaudio, gabriella/AAN-6039-2021 57201049419; 55654886100; 57987123200; 57207893123; 15843180700; 35227360000; 57257924100; 57202249553; 35278894500; 8680451900; 6603371615; 7003708514 lorenzo.pezzotti01@universitadipavia.it; NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT NUCL INSTRUM METH A 0168-9002 1872-9576 958 SCIE INSTRUMENTS & INSTRUMENTATION;NUCLEAR SCIENCE & TECHNOLOGY;PHYSICS, NUCLEAR;PHYSICS, PARTICLES & FIELDS 2020 1.455 48.5 0.34 2025-06-25 3 5 Future colliders; IDEA Detector; Dual-readout calorimetry Dual-readout calorimetry; Future colliders; IDEA Detector Calorimetry; Germanium compounds; Positrons; Dual readout calorimetries; Dual readouts; Energy resolutions; Final state; High resolution; Ultra-light; Calorimeters English 2020 2020-04-01 10.1016/j.nima.2019.04.017 바로가기 바로가기 바로가기 바로가기
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Keywords (WoS) 저자가 논문에서 직접 지정한 키워드입니다. Web of Science에 등록된 저자 키워드 목록입니다.
KeywordsPlus (WoS) Web of Science에서 자동으로 추출한 추가 키워드입니다. 논문의 참고문헌 제목에서 자주 등장하는 단어들로 생성됩니다.
Keywords (SCOPUS) 저자가 논문에서 직접 지정한 키워드입니다. SCOPUS에 등록된 저자 키워드 목록입니다.
KeywordsPlus (SCOPUS) SCOPUS에서 자동으로 추출하거나 추가한 색인 키워드입니다.
Language 논문이 작성된 언어입니다. 대부분 English이며, 그 외 다양한 언어로 작성된 논문이 포함될 수 있습니다.
Publication Year 논문이 출판된 연도입니다.
Publication Date 논문의 정확한 출판 날짜입니다 (년-월-일 형식).
DOI Digital Object Identifier. 디지털 객체 식별자로, 논문을 고유하게 식별하는 영구적인 식별번호입니다. 이를 통해 논문의 온라인 위치를 찾을 수 있습니다.