연구성과로 돌아가기
2021 연구성과 (159 / 281)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Supervised Learning Based Peripheral Vision System for Immersive Visual Experiences for Extended Display | Video display content can be extended to the walls of the living room around the TV using projection. The problem of providing appropriate projection content is hard for the computer and we solve this problem with deep neural network. We propose the peripheral vision system that provides the immersive visual experiences to the user by extending the video content using deep learning and projecting that content around the TV screen. The user may manually create the appropriate content for the existing TV screen, but it is too expensive to create it. The PCE (Pixel context encoder) network considers the center of the video frame as input and the outside area as output to extend the content using supervised learning. The proposed system is expected to pave a new road to the home appliance industry, transforming the living room into the new immersive experience platform. | Shirazi, Muhammad Ayaz; Uddin, Riaz; Kim, Min-Young | Kyungpook Natl Univ, IT Coll, Sch Elect Engn, 1370 Sankyuk Dong, Daegu 41566, South Korea; NED Univ Engn & Technol, Natl Ctr Robot & Automat, Hapt Human Robot & Condit Monitoring Lab, Karachi 75270, Pakistan; NED Univ Engn & Technol, Dept Elect Engn, Karachi 75270, Pakistan; Kyungpook Natl Univ, Res Ctr Neurosurg Robot Syst, 1370 Sankyuk Dong, Daegu 41566, South Korea | Uddin, Riaz/Z-4173-2019 | 55935434300; 55547397400; 56739349100 | mshirazi@ee.knu.ac.kr;riazuddin@neduet.edu.pk;minykim@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 11 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 0.07 | 2025-07-30 | 0 | 1 | augmented video; human vision; immersion; large field of view; spatial augmented reality; video extrapolation; neural network; AI | AI; Augmented video; Human vision; Immersion; Large field of view; Neural network; Spatial augmented reality; Video extrapolation | English | 2021 | 2021-06 | 10.3390/app11114726 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Synergistic Effects and Toxic Mechanism of Phosphine with Ethyl Formate against Citrus Mealybug (Planococcus citri) | Featured Application: The objective of the work is to assess alternatives to methyl bromide such as ethyl formate and phosphine for the control of insect pests in the quarantine process. Methyl bromide (MB) has been used in a wide range of applications, but since it was determined to be an ozone-depleting compound, it has only been used for pre-shipment and quarantine purposes in trade. Phosphine (PH3) is currently the ideal fumigant as an MB alternative worldwide. However, the development of PH3 resistance in the target insect pest and longer PH3 fumigation treatment times raise questions about the continued use of PH3. This study attempted to shorten treatment time via combination treatment with ethyl formate (EF). Planococcus citri was used as the main quarantine pest in Korea, and the acute toxicity of EF, PH3, and EF + PH3 was determined at every developmental stage. EF treatment at 4 h showed LCT99 values of 45.85 similar to 65.43 mg center dot h/L, and PH3 treatment at 20 h showed that of 0.13 similar to 0.83 mg center dot h/L depending on the developmental stage. The efficacy of PH3 decreased after reducing the treatment time, but synergistic effects were observed at all stages of development of P. citri when both fumigants were used simultaneously for 4 h. After combined treatment, dihydrolipoyl dehydrogenase expression and the production of two phospholipids, PI(O-16:0) and PC(18:2), were significantly reduced in treated P. citri adults compared with the control. Therefore, combined treatments might be key to reducing the treatment time and resistance of PH3 in the field. | Kim, Kyeongnam; Park, Min-Goo; Lee, Yong Ho; Jeon, Hwang-Ju; Kwon, Tae Hyung; Kim, Chaeeun; Park, Jungeun; Lee, Byung-Ho; Yang, Jeong Oh; Lee, Sung-Eun | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Plant Quarantine Technol Ctr, Anim & Plant Quarantine Agcy, Gimcheon 39660, South Korea; Hankyong Natl Univ, Inst Ecol Phytochem, Ansung 17579, South Korea; Gyeongsang Natl Univ, Inst Life Sci, Div Appl Life Sci, BK21 Program, Jinju 52828, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Gyeongsang Natl Univ, Inst Agr & Life Sci, Jinju 52828, South Korea; Yeongnam Reg Off, Anim & Plant Quarantine Agcy, Busan 48943, South Korea | ; Jeon, Hwangju/JDW-9035-2023; Kim, Kyeongnam/KSM-2719-2024; Park, Min-Goo/AAV-5273-2020 | 57191364349; 57213595173; 57201926028; 56328792200; 57215832186; 57200245142; 58363479900; 57202841615; 8890124100; 55890041600 | pmg@korea.kr;yonghoyongho@hanmail.net;xoxogudgud@naver.com;byungholee@gnu.ac.kr;joyang12@korea.kr;selpest@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 21 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 0.3 | 2025-07-30 | 8 | 6 | quarantine pest; methyl bromide alternatives; anti-resistance strategy; dihydrolipoyl dehydrogenase; phospholipids | RHYZOPERTHA-DOMINICA; MANAGEMENT STRATEGIES; TRIBOLIUM-CASTANEUM; STORED-PRODUCT; METHYL-BROMIDE; RESISTANCE; COMBINATION; FUMIGATION; RESPONSES; INSECTS | Anti-resistance strategy; Dihydrolipoyl dehydrogenase; Methyl bromide alternatives; Phospholipids; Quarantine pest | English | 2021 | 2021-11 | 10.3390/app11219877 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | The Integration of Earthwork Design Review and Planning Using UAV-Based Point Cloud and BIM | Featured Application Construction engineering in earthwork operation. Earthwork is seemingly guesswork, but it requires a high level of accuracy and precise planning. Differences between earthwork design and finishing levels cause project delays and cost overrun due to the time-consuming nature of earthwork re-work. Therefore, error-free earthwork planning and design review is a key to the success of earthwork projects. This study utilized an integrated approach of an unmanned aerial vehicle (UAV)-based point cloud and BIM (Building Information Modeling) to verify the design and to operate the earthwork planning. The integrated approach was proposed and applied to a 420 square meters housing construction project to review an original earthwork design and create an earthwork plan for excavator work. As a result, errors in earthwork design that caused by inaccurate initial DEM was revealed, thus the earthwork design was revised with a UAV-based point cloud map. Additionally, the integrated approach was able to generate an explicit task sequence for an excavator. | Kim, Jeonghwan; Lee, Soomin; Seo, Jongwon; Lee, Dong-Eun; Choi, Hee Seon | Korea Natl Univ Transportat, Dept Civil Engn, Chungju Si 27469, South Korea; Hanyang Univ, Dept Civil & Environm Engn, Seoul 04763, South Korea; Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, Daegu 41566, South Korea; Cheongju Univ, Dept Environm Landscape Architecture Engn, Cheongju 28503, South Korea | 55720258400; 57219602036; 7401783784; 56605563300; 57223046713 | jeonghwan.kim@ut.ac.kr;dltnalsfor@hanyang.ac.kr;jseo@hanyang.ac.kr;dolee@knu.ac.kr;yena1866@empas.com; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 8 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 1.7 | 2025-07-30 | 23 | 26 | earthwork; point cloud; excavation; BIM; UAV; earthwork design | BIM; Earthwork; Earthwork design; Excavation; Point cloud; UAV | English | 2021 | 2021-04 | 10.3390/app11083435 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Truncated elliptical Self-Complementary antenna with Quad-Band notches for SWB MIMO systems | In this work, a compact four-element super-wideband (SWB) multiple-input-multiple-output (MIMO) antenna with four notched bands is designed. The unit resonating element of the MIMO antenna consists of a semi-elliptical monopole patch with high eccentricity. The elliptical patch of the antenna element is truncated from the top to develop a polarization diversity-based compact MIMO configuration. In the coplanar ground surface, a flipped-slot of matched geometry is introduced, which complements the truncated antenna element. Also, four slit-resonators are introduced in the radiating patch of the antenna element to eliminate Wi-Fi, WLAN, Wi-MAX, and X-band signals (2.4, 3.5, 5.5, and 8.5 GHz, respectively) from the SWB. In the proposed quad-port SWB-MIMO configuration, the truncated elliptical self-complementary antenna (TESCA) elements are arranged in rotational symmetry and mutually orthogonal to each other. The diversity antenna exhibits impedance bandwidth (for vertical bar S-11 vertical bar < -10 dB) from 1.15 to 40 GHz (bandwidth ratio similar to 35:1), inter-element isolation greater than 18 dB, and ECC < 0.005. The proposed four-element diversity antenna may be a good candidate for cognitive radio and ubiquitous applications. | Raheja, Dinesh Kumar; Kumar, Sachin; Kanaujia, Binod Kumar; Palaniswamy, Sandeep Kumar; Thipparaju, Rama Rao; Kanagasabai, Malathi | Netaji Subhas Univ Technol, Dept Elect & Commun Engn, New Delhi 110078, India; SRM Inst Sci & Technol, Dept Elect & Commun Engn, Kattankulathur 603203, India; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Jawaharlal Nehru Univ, Sch Computat & Integrat Sci, New Delhi 110067, India; Anna Univ, Dept Elect & Commun Engn, Chennai 600025, Tamil Nadu, India | Kanagasabai, Malathi/ABH-5331-2020; Kanaujia, Binod/L-6484-2019; kanaujia, Binod/L-6484-2019; PALANISWAMY, SANDEEP KUMAR/AAF-2240-2021; T, Dr.Prof. Rama Rao/AAE-6953-2021; Kumar, Sachin/W-2211-2019; Palaniswamy, Sandeep Kumar/AAF-2240-2021 | 57192106958; 56907994000; 56962785800; 57221937207; 35073094200; 55511179300 | dineshraheja102@gmail.com;gupta.sachin0708@gmail.com;bkkanaujia@ieee.org;vrpchs@gmail.com;ramaraotr@gmail.com;mala@annauniv.edu; | AEU-INTERNATIONAL JOURNAL OF ELECTRONICS AND COMMUNICATIONS | AEU-INT J ELECTRON C | 1434-8411 | 1618-0399 | 131 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2021 | 3.169 | 41.9 | 1.06 | 2025-07-30 | 15 | 17 | Elliptical; MIMO; Notches; Self-complementary; SWB | Elliptical; MIMO; Notches; Self-complementary; SWB | Bandwidth; Cognitive radio; Electric impedance; Microstrip antennas; MIMO systems; Monopole antennas; Slot antennas; Wireless local area networks (WLAN); Elliptical monopoles; Impedance bandwidths; Multiple input multiple output antennas; Polarization diversity; Resonating elements; Rotational symmetries; Self-complementary antennas; Ubiquitous application; Microwave antennas | English | 2021 | 2021-03 | 10.1016/j.aeue.2021.153608 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Two-Phase Flow Simulations Using 1D Centerline-Based C- and U-Shaped Pipe Meshes | This study aims to investigate the pressure changes, bubble dynamics, and flow physics inside the U- and C-shaped pipes with four different gravitational directions. The simulation is performed using a 1D centerline-based mesh generation technique along with a two-fluid model in the open-source software, OpenFOAM v.6. The continuity and momentum equations of the two-fluid model are discretized using the pressure-implicit method for the pressure-linked equation algorithm. The static and hydrostatic pressures in the two-phase flow were consistent with those of single-phase flow. The dynamic pressure in the two-phase flow was strongly influenced by the effect of the buoyancy force. In particular, if the direction of buoyancy force is the same as the flow direction, the dynamic pressure of the air phase increases, and that of the water phase decreases to satisfy the law of conservation of mass. Dean flows are observed on the transverse plane of the curve regions in both C-shaped and U-shaped pipes. The turbulent kinetic energy is stronger in a two-phase flow than in a single-phase flow. Using the 1D centerline-based mesh generation technique, we demonstrate the changes in pressure and the turbulent kinetic energy of the single- and two-phase flows, which could be observed in curve pipes. | Pham, Thinh Quy Duc; Jeon, Jichan; Jo, Daeseong; Choi, Sanghun | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | ; Choi, Sanghun/AGS-7430-2022 | 57215673039; 57210139607; 16424303000; 55847101000 | pqducthinhbka@knu.ac.kr;jjc1030@knu.ac.kr;djo@knu.ac.kr;s-choi@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 5 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 0.15 | 2025-07-30 | 1 | 2 | pressure drop; dynamic pressure; two-fluid model; computational fluid dynamics; volume fraction | Computational fluid dynamics; Dynamic pressure; Pressure drop; Two-fluid model; Volume fraction | English | 2021 | 2021-03 | 10.3390/app11052020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Validation of Eye Temperature Assessed Using Infrared Thermography as an Indicator of Welfare in Horses | This study aimed to validate eye temperature (ET) assessed using infrared thermography (IRT) as an indicator of welfare in horses. Moreover, this study aimed to determine the most accurate position for ET measured using IRT and to validate this approach as a gold-standard measurement method. As the quantitative data obtained by IRT have strongly influenced the ET results depending on the specific location of the measurement area, an accurate definition of the regions of interest (ROI) was established. A total of 176 horses (Thoroughbred, Warmblood, and Halla horses) were used at the racing course of the Korea Racing Authority and public horse-riding clubs in South Korea. The present study also compared temperatures among three ROIs of the eye-lacrimal sac, medial canthus, and lateral canthus-at rest. Correlations between ET, rectal temperature (RT), heart rate (HR), and respiratory rate (RR) were assessed. There were no significant correlations between HR, RR or RT; however, among the three ROIs, the temperature of the medial canthus was positively correlated with RT (p < 0.05). Furthermore, the size of ROI was negatively correlated with accuracy of temperature measurement. These results indicate that the most suitable area for ET measurement using IRT in horses is the medial canthus, and it is recommended to use the average temperature of the smallest ROIs (2 x 2 pixels) for temperature analysis. Therefore, this study offers a validated protocol in which ET measured using IRT in the horses is useful as an indicator of welfare. | Kim, Su-Min; Cho, Gil-Jae | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Equine Med, Daegu 41566, South Korea | 57216751253; 7201438083 | liebe_sm@naver.com;chogj@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 16 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 1.48 | 2025-07-30 | 23 | 24 | eye temperature; horse; infrared thermography; medial canthus; rectal temperature | STRESS ASSESSMENT; HEART-RATE; MANAGEMENT | Eye temperature; Horse; Infrared thermography; Medial canthus; Rectal temperature | English | 2021 | 2021-08 | 10.3390/app11167186 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Antimalarial Effect of the Total Glycosides of the Medicinal Plant, Ranunculus japonicus | In traditional Chinese medicine, Ranunculus japonicus has been used to treat various diseases, including malaria, and the young stem of R. japonicus is consumed as a food in the Republic of Korea. However, experimental evidence of the antimalarial effect of R. japonicus has not been evaluated. Therefore, the antimalarial activity of the extract of the young stem of R. japonicus was evaluated in vitro using both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) strains; in vivo activity was evaluated in Plasmodium berghei-infected mice via oral administration followed by a four-day suppressive test focused on biochemical and hematological parameters. Exposure to extracts of R. japonicus resulted in significant inhibition of both chloroquine-sensitive (3D7) and resistant (Dd2) strains of P. falciparum, with IC50 values of 6.29 +/- 2.78 and 5.36 +/- 4.93 mu g/mL, respectively. Administration of R. japonicus also resulted in potent antimalarial activity against P. berghei in infected mice with no associated toxicity; treatment also resulted in improved hepatic, renal, and hematologic parameters. These results demonstrate the antimalarial effects of R. japonicus both in vitro and in vivo with no apparent toxicity. | Yun, Hae-Soo; Dinzouna-Boutamba, Sylvatrie-Danne; Lee, Sanghyun; Moon, Zin; Kwak, Dongmi; Rhee, Man-Hee; Chung, Dong-Il; Hong, Yeonchul; Goo, Youn-Kyoung | Kyungpook Natl Univ, Sch Med, Dept Parasitol & Trop Med, Daegu 41944, South Korea; Korea CDC, Korea Natl Inst Hlth, Div Zoonot & Vector Borne Dis Res, Ctr Infect Dis, Chungbuk 28159, South Korea; Chungbuk Natl Univ, Dept Microbiol, Coll Med, Cheongju 28644, South Korea; Chungbuk Natl Univ, Med Res Inst, Cheongju 28644, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Parasitol, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Physiol & Cell Signaling, Daegu 41566, South Korea | ; Rhee, Man/O-5705-2016 | 57194170243; 56299947300; 56272461500; 57223389298; 7007148758; 57211035357; 13310373300; 7403392847; 22937863200 | sooandart@naver.com;sylvatriez@yahoo.fr;cdcsanghyun@gmail.com;zinmoonkcn@gmail.com;dmkwak@knu.ac.kr;rheemh@knu.ac.kr;dichung@knu.ac.kr;ychong@knu.ac.kr;kuku1819@knu.ac.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 10 | 5 | SCIE | MICROBIOLOGY | 2021 | 4.531 | 42.0 | 0.53 | 2025-07-30 | 8 | 8 | Ranunculus japonicus; plasmodium falciparum; plasmodium berghei; antimalarial effect | PLASMODIUM-FALCIPARUM; IN-VIVO; MALARIA; BERGHEI; VITRO | Antimalarial effect; Plasmodium berghei; Plasmodium falciparum; Ranunculus japonicus | alanine aminotransferase; artemisinin; aspartate aminotransferase; bilirubin; chloroquine; creatinine; gentamicin; glycoside; plant extract; Ranunculus japonicus extract; sorbitol; unclassified drug; urea; animal cell; animal experiment; animal model; antimalarial activity; Article; bacterial strain; cytotoxicity; enzyme linked immunosorbent assay; female; hematocrit; hematological parameters; IC50; in vitro study; in vivo study; liver toxicity; mouse; MTT assay; nephrotoxicity; nonhuman; parasitemia; Plasmodium berghei; Plasmodium falciparum; Ranunculus; Ranunculus japonicus | English | 2021 | 2021-05 | 10.3390/pathogens10050532 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Co-Infection with Anaplasma Species and Novel Genetic Variants Detected in Cattle and Goats in the Republic of Korea | Anaplasmosis, a tick-borne disease with multiple reservoirs, has been evolving in its pathogenesis, increasing domestic ruminants susceptibility to simultaneous infections with multiple pathogens. However, there is limited information regarding anaplasmosis in domestic ruminants in the Republic of Korea (ROK). We aimed to evaluate the role of Korean cattle and goats in Anaplasma infection maintenance. Polymerase chain reaction was performed to investigate the prevalence and genetic diversity of Anaplasma spp. from 686 whole blood samples collected from different ROK provinces. Anaplasma infection was mostly caused by A. phagocytophilum (21.1%) in cattle, and A. bovis (7.3%) in goats. Co-infection cases were found in cattle: A. bovis and A. phagocytophilum (16.7%), and in goats: A. bovis and A. capra (1.0%). Notably, a triple co-infection with A. bovis, A. phagocytophilum, and A. capra was found in one cow. Phylogenetic analysis revealed novel variants of the A. phagocytophilum 16S rRNA and A. capra gltA genes. This research contributes to the ratification of cattle as a potential reservoir of A. capra and demonstrates Anaplasma co-infection types in Korean domestic ruminants. As anaplasmosis is a zoonotic disease, our study could be crucial in making important decisions for public health. | Miranda, Evelyn Alejandra; Han, Sun-Woo; Cho, Yoon-Kyong; Choi, Kyoung-Seong; Chae, Joon-Seok | Seoul Natl Univ, Lab Vet Internal Med, PLUS Program Creat Vet Sci Res BK21, Res Inst Vet Sci, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Coll Vet Med, 1 Gwanak Ro, Seoul 08826, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Sangju 37224, South Korea | 57221444863; 57216636732; 57201634305; 7403949556; 7102478039 | evelyn_ale08@hotmail.com;suntina227@snu.ac.kr;hmhm0410@snu.ac.kr;kschoi3@knu.ac.kr;jschae@snu.ac.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 10 | 1 | SCIE | MICROBIOLOGY | 2021 | 4.531 | 42.0 | 1.89 | 2025-07-30 | 29 | 30 | Anaplasma phagocytophilum; Anaplasma bovis; Anaplasma capra; cattle; goat; co-infection; Republic of Korea | Anaplasma bovis; Anaplasma capra; Anaplasma phagocytophilum; Cattle; Co-infection; Goat; Republic of Korea | genomic DNA; RNA 16S; agar gel electrophoresis; Anaplasma; Anaplasmataceae infection; Article; Babesia; bacterium isolation; bioinformatics; blood sampling; controlled study; DNA extraction; DNA isolation; dog; domestic cat; gene amplification; gene fragment; gene sequence; genetic counseling; genetic variability; genotype; geographic distribution; goat; infection rate; mixed infection; molecular identification; mutational analysis; nested polymerase chain reaction; nonhuman; nucleotide sequence; nucleotide sequence; phylogenetic tree; polymerase chain reaction; prevalence; public health; rash; Rhipicephalus microplus; ruminant; sequence alignment; sequence analysis; sequence homology; single nucleotide polymorphism; South Korea; tick infestation | English | 2021 | 2021-01 | 10.3390/pathogens10010028 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Colistin Induces Resistance through Biofilm Formation, via Increased phoQ Expression, in Avian Pathogenic Escherichia coli | This study aimed to optimize the colistin-based antibacterial therapy to prevent antimicrobial resistance related to biofilm formation in avian pathogenic Escherichia coli (APEC) in chicken. Of all the bacterial isolates (n = 136), 69 were identified as APEC by polymerase chain reaction (PCR). Through a series of antibiotic susceptibility tests, susceptibility to colistin (< 2 mu g/mL) was confirmed in all isolates. Hence, a mutant selection window (MSW) was determined to obtain colistin-induced resistant bacteria. The minimum inhibitory concentration (MIC) of colistin against the colistin-induced resistant APEC strains ranged from 8 to 16 mu g/mL. To identify the inhibitory activity of colistin against the resistant strains, the mutant prevention concentration (MPC) was investigated for 72 h, and the single and multi-dose colistin activities were determined through the time-kill curve against APEC strains. Bacterial regrowth occurred after 12 h at a double MIC50 concentration (1.00 mu g/mL), and regrowth was not inhibited even during multiple exposures. However, upon exposure to 8 mu g/mL-a concentration that was close to the MPC-the growth of APEC was inhibited, including in the resistant strains. Additionally, colistin-induced resistant strains showed a slower growth compared with the susceptible ones. Colistin-induced resistant APEC strains did not show colistin resistance gene (mcr-1). However, the expression of higher mgrB and phoQ levels was observed in the resistant strains. Furthermore, these strains showed increased formation of biofilm. Hence, the present study indicated that colistin could induce resistance through the increased formation of biofilm in APEC strains by enhancing the expression of phoQ. | Park, Na-Hye; Lee, Seung-Jin; Lee, Eon-Bee; Birhanu, Biruk Tesfaye; Park, Seung-Chun | Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea; Korea Inst Toxicol, Reprod & Dev Toxicol Res Grp, Daejeon 34114, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea | Lee, Jun Young/CAI-2335-2022; Lee, Jung Bok/HHZ-3200-2022; Park, Seung-Chun/AAV-3388-2021; Birhanu, Biruk/F-1622-2017 | 57192425603; 58689440900; 57216526135; 56996190000; 7501832396 | pnh0211@dgmif.re.kr;lee.seungjin@kitox.re.kr;eonbee@gmail.com;biruk.birhanu@knu.ac.kr;parksch@knu.ac.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 10 | 11 | SCIE | MICROBIOLOGY | 2021 | 4.531 | 42.0 | 0.45 | 2025-07-30 | 6 | 6 | antibacterial therapy; colistin; Avian Pathogenic Escherichia coli (APEC); antibiotic resistance; biofilm formation | MUTANT-PREVENTION CONCENTRATION; ANTIBIOTIC-RESISTANCE; KLEBSIELLA-PNEUMONIAE; IN-VITRO; SALMONELLA-TYPHIMURIUM; EMERGENCE; CIPROFLOXACIN; ENVIRONMENT; MECHANISMS; ANIMALS | Antibacterial therapy; Antibiotic resistance; Avian Pathogenic Escherichia coli (APEC); Biofilm formation; Colistin | amlodipine; gentamicin; hemagglutinin; kanamycin; tetracycline; virulence factor; agar diffusion; antibiotic resistance; antibiotic sensitivity; antibiotic therapy; Article; bacterial count; bacterial growth; bacterial virulence; biofilm; cell viability; Escherichia coli; fluorescence microscopy; gene expression; genetic similarity; minimum bactericidal concentration; nonhuman; polymerase chain reaction; pyelonephritis; quality control; scanning electron microscopy; zone of inhibition | English | 2021 | 2021-11 | 10.3390/pathogens10111525 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of the Variability of the ORF34, ORF68, and MLST Genes in EHV-1 from South Korea | Equine herpesvirus-1 (EHV-1) is an important pathogen in horses. It affects horses worldwide and causes substantial economic losses. In this study, for the first time, we characterized EHV-1 isolates from South Korea at the molecular level. We then aimed to determine the genetic divergences of these isolates by comparing them to sequences in databases. In total, 338 horse samples were collected, and 12 EHV-1 were isolated. We performed ORF30, ORF33, ORF68, and ORF34 genetic analysis and carried out multi-locus sequence typing (MLST) of 12 isolated EHV-1. All isolated viruses were confirmed as non-neuropathogenic type, showing N752 of ORF30 and highly conserved ORF33 (99.7-100%). Isolates were unclassified using ORF68 analysis because of a 118 bp deletion in nucleotide sequence 701-818. Seven EHV-1 isolates (16Q4, 19R166-1, 19R166-6, 19/10/15-2, 19/10/15-4, 19/10/18-2, 19/10/22-1) belonged to group 1, clade 10, based on ORF34 and MLST analysis. The remaining 5 EHV-1 isolates (15Q25-1, 15D59, 16Q5, 16Q40, 18D99) belonged to group 7, clade 6, based on ORF34 and MLST analysis. | Kang, Hyung-Woo; Lee, Eun-Yong; Lee, Kyoung-Ki; Ko, Mi-Kyeong; Park, Ji-Young; Kim, Yeon-Hee; Lee, Kyunghyun; Choi, Eun-Jin; Kim, Jongho; So, ByungJae; Park, Choi-Kyu; Jeoung, Hye-Young | Anim & Plant Quarantine Agcy, 177 Hyeoksin 8 Ro, Gimcheon Si 39660, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Anim Dis Intervent Ctr, Daegu 41566, South Korea | 57209455852; 55445019000; 38163138800; 56291124400; 56095792500; 57203809456; 35183367100; 26651895700; 57202162365; 56366161500; 24768064900; 54924137400 | guddn1812@korea.kr;agdragon@korea.kr;naturelkk@korea.kr;mkk80@korea.kr;parkck@knu.ac.kr;vetyh@korea.kr;mylovehyun@korea.kr;choiej@korea.kr;whdgh2339@korea.kr;bjso@korea.kr;jhy98@korea.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 10 | 4 | SCIE | MICROBIOLOGY | 2021 | 4.531 | 42.0 | 0.23 | 2025-07-30 | 4 | 4 | EHV-1; ORF30; ORF33; ORF34; ORF68; MLST; phylogeny | EQUINE HERPESVIRUS TYPE-1; MOLECULAR CHARACTERIZATION; ABORTED FETUSES; STRAINS; MYELOENCEPHALOPATHY; PATHOGENESIS; OUTBREAK; HUNGARY; DISEASE | EHV-1; MLST; ORF30; ORF33; ORF34; ORF68; Phylogeny | article; cladistics; controlled study; Equid herpesvirus 1; gene deletion; genetic analysis; genetic variability; major clinical study; nonhuman; nucleotide sequence; phylogeny; South Korea | English | 2021 | 2021-04 | 10.3390/pathogens10040425 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Initial experience of preoperative short-course radiotherapy followed by oxaliplatin-based consolidation chemotherapy for locally advanced rectal cancer | Purpose We analyzed the safety and feasibility of preoperative short-course radiotherapy (SCRT) followed by consolidation chemotherapy for patients with locally advanced rectal cancer (LARC). Methods From April 2018 to May 2019, 19 patients with LARC were treated with SCRT followed by three cycles of consolidation chemotherapy with leucovorin, fluorouracil, and oxaliplatin (FOLFOX6) before surgery. Adjuvant chemotherapy relied on oxaliplatin. Tumor response, patient compliance, and toxicities were analyzed. Results The median age was 60 years (range 44-71), and 16 of the patients were male. The median tumor height was 5 cm (range 0-9) from anal verge. All patients received a total dose of 25 Gy in five fractions. The number of cycles of FOLFOX6 before surgery was three in 17, four in one, five in one. Five patients required dose reductions in consolidation chemotherapy. The median interval between initiation of SCRT and surgery was 10.6 weeks (range 8.6-16.4). A pathologic complete response was seen in two patients (11%). Grade III toxicities to the preoperative treatment were seen in five patients (26%): diarrhea in two, a decreased white blood cell count in one, and anemia in two. Postoperative complications arising within 30 days developed in five patients (26%). During the median follow-up period of 20.4 months, there was no tumor recurrence. Conclusion Preoperative SCRT followed by oxaliplatin-based consolidation chemotherapy showed acceptable toxicity and feasibility in patients with LARC. Prospective randomized trials are warranted to verify the efficacy and safety of this treatment strategy compared with conventional long-course concurrent chemoradiotherapy. | Song, Seung Ho; Park, Jun Seok; Kang, Min Kyu; Choi, Gyu-Seog; Park, Soo Yeun; Kim, Hye Jin; Kim, Jong Gwang; Kang, Byung Woog; Baek, Jin Ho; Baek, Dong Won; Kim, Jae-Chul; Park, Shin-Hyung; Cho, Seung Hyun; Seo, An Na | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Colorectal Canc Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea | Kim, Hye/W-1059-2019; Kim, Sung-Bae/JXL-8219-2024; Park, Joonhong/AAZ-9885-2020; Park, Shinhyung/LNQ-6428-2024; KANG, MIN KYU/ACI-8824-2022 | 57221771693; 35226761100; 57201933342; 8058759100; 40561578300; 57204567554; 59501049300; 28567838500; 57217075847; 57191874272; 55719981700; 57203275843; 55686242700; 55804153700 | parkjs0802@knu.ac.kr;mkkang@knu.ac.kr; | INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | INT J COLORECTAL DIS | 0179-1958 | 1432-1262 | 36 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2021 | 2.796 | 42.0 | 0.2 | 2025-07-30 | 2 | 2 | Rectal cancer; Short-course radiotherapy; Consolidation chemotherapy; Total mesorectal excision | Consolidation chemotherapy; Rectal cancer; Short-course radiotherapy; Total mesorectal excision | Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Consolidation Chemotherapy; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Neoplasm Staging; Oxaliplatin; Prospective Studies; Rectal Neoplasms; fluorouracil; folinic acid; oxaliplatin; antineoplastic agent; fluorouracil; folinic acid; oxaliplatin; abdominal pain; adult; aged; anal pain; anastomosis leakage; anemia; anus disease; Article; atrial fibrillation; cancer adjuvant therapy; cancer chemotherapy; cancer patient; cancer radiotherapy; cancer surgery; clinical article; clinical effectiveness; clinical evaluation; controlled study; diarrhea; drug dose reduction; drug efficacy; drug safety; feasibility study; female; follow up; human; ileus; leukocyte; leukocyte count; male; multiple cycle treatment; patient compliance; postoperative complication; preoperative care; prospective study; radiation dose; rectum cancer; rectum hemorrhage; short course therapy; side effect; urine retention; adverse event; cancer staging; chemoradiotherapy; consolidation chemotherapy; middle aged; neoadjuvant therapy; rectum tumor; tumor recurrence | English | 2021 | 2021-06 | 10.1007/s00384-021-03875-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Long-term impacts of appendectomy associated with increased incidence of inflammatory bowel disease, infection, and colorectal cancer | Purpose Although the appendix has been suggested to play a role in maintaining the gut microbiome and immune system, the ramifications of appendectomy on the development inflammatory bowel disease, sepsis, and colorectal cancer are yet to be determined. The purpose of this study was to evaluate the potential long-term impacts of appendectomy, with a focus on inflammatory bowel disease, infection, and colorectal cancer, using the National Healthcare Insurance Service (NHIS) database of Korea. Methods The National Healthcare Insurance Service database in Korea was used for analysis. Adult patients who received appendectomy between 2005 and 2013 were identified. The control group consisted of patients who did not receive appendectomy were matched by baseline characteristics including comorbidities and frequency of healthcare resource utilization. The primary outcome was the incidence-rate ratio (IRR) of Crohn's disease, ulcerative colitis, Clostridium difficile infection, sepsis, and colorectal cancer after appendectomy or the index date. Results We identified 914,208 patients who underwent appendectomy, and after matching with control patients, a total of 486,844 patients were included for analysis. Patients who underwent appendectomy showed a significantly higher incidence of Crohn's disease (IRR 4.40, 95% confidence interval (CI) 3.78-5.13) and ulcerative colitis (IRR 1.78, 95% CI 1.63-1.93) compared to the control group during the 5-year follow-up period. The associations between appendectomy and Clostridium difficile infection, sepsis, and colorectal cancer were all found to be significant. Conclusion Patients who underwent appendectomy may be at increased risk for developing Crohn's disease, ulcerative colitis, Clostridium difficile infection, sepsis, and colorectal cancer. | Lee, Seohee; Jang, Eun Jin; Jo, Junwoo; Park, So Jung; Ryu, Ho Geol | Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Anesthesiol & Pain Med, 101 Daehak Ro, Seoul 03080, South Korea; Andong Natl Univ, Dept Informat Stat, 1375 Gyeongdong Ro, Andong 36729, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Dept Stat, 80 Daehak Ro, Daegu 41566, South Korea | Ryu, Ho/J-5463-2012 | 57199185656; 37861741600; 57210425017; 57827186000; 7202277246 | hogeol@gmail.com; | INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | INT J COLORECTAL DIS | 0179-1958 | 1432-1262 | 36 | 8 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;SURGERY | 2021 | 2.796 | 42.0 | 1.56 | 2025-07-30 | 17 | 19 | Appendectomy; Clostridium difficile infection; Colorectal cancer; Inflammatory disease; Sepsis | Appendectomy; Clostridium difficile infection; Colorectal cancer; Inflammatory disease; Sepsis | Adult; Appendectomy; Colitis, Ulcerative; Colorectal Neoplasms; Humans; Incidence; Inflammatory Bowel Diseases; Republic of Korea; Risk Factors; adolescent; adult; appendectomy; Article; cerebrovascular disease; child; chronic kidney failure; Clostridium difficile infection; cohort analysis; colorectal cancer; controlled study; coronary artery disease; Crohn disease; diabetes mellitus; female; follow up; health care facility; health care system; hospital admission; hospitalization; human; hypertension; ICD-10; immune system; incidence; infection; inflammatory bowel disease; Kaplan Meier method; major clinical study; male; outcome assessment; outpatient department; propensity score; retrospective study; school child; sepsis; ulcerative colitis; adverse event; appendectomy; colorectal tumor; incidence; inflammatory bowel disease; risk factor; South Korea; ulcerative colitis | English | 2021 | 2021-08 | 10.1007/s00384-021-03886-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Pharmacokinetic/Pharmacodynamic Modeling of Spiramycin against Mycoplasma synoviae in Chickens | This research aimed to assess the pharmacokinetics/pharmacodynamics (PK/PD) and tissue residues of spiramycin in chickens. The PK of spiramycin were determined in 12 chickens using a parallel study design in which each group of chickens (n = 6) received a single dose of spiramycin at 17 mg/kg intravenously (IV) or orally. Plasma samples were collected at assigned times for up to 48 h to measure spiramycin concentrations. Additionally, a tissue depletion study was performed in 42 chickens receiving spiramycin at 17 mg/kg/day orally for 7 days. The area under the plasma concentration-time curve values were 29.94 & PLUSMN; 4.74 and 23.11 & PLUSMN; 1.83 mu g*h/mL after IV and oral administrations, respectively. The oral bioavailability was 77.18%. The computed withdrawal periods of spiramycin were 11, 10, and 7 days for liver, muscle, and skin and fat, respectively. The minimum inhibitory concentration for spiramycin against Mycoplasma synoviae (M. synoviae) strain 1853 was 0.0625 mu g/mL. Using the PK/PD integration, the appropriate oral dose of spiramycin against M. synoviae was estimated to be 15.6 mg/kg. Thus, we recommend an oral dose of 15.6 mg spiramycin/kg against M. synoviae in chickens and a withdrawal period of 11 days following oral treatment with 17 mg spiramycin/kg/day for 7 days. | Elazab, Sara T.; Elshater, Nahla S.; Hashem, Yousreya H.; Al-Atfeehy, Nayera M.; Lee, Eon-Bee; Park, Seung-Chun; Hsu, Walter H. | Mansoura Univ, Dept Pharmacol, Fac Vet Med, Mansoura 35516, Egypt; Agr Res Ctr, Anim Hlth Res Inst, Reference Lab Vet Qual Control Poultry Prod, Giza 12618, Egypt; Agr Res Ctr, Anim Hlth Res Inst, Mycoplasma Res Dept, Giza 12618, Egypt; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Iowa State Univ, Dept Biomed Sci, Coll Vet Med, Ames, IA 50011 USA | ; Elazab, Sara/L-8955-2018; Park, Seung-Chun/AAV-3388-2021; Lee, Jung Bok/HHZ-3200-2022 | 57195244229; 57211744199; 57209322857; 56543676000; 57216526135; 7501832396; 7402002883 | sarataha1@mans.edu.eg;nahlaelshater80@gmail.com;yousreya@gmail.com;hanya_noour@yahoo.com;eonbee@gmail.com;parksch@knu.ac.kr;whsu@iastate.edu; | PATHOGENS | PATHOGENS | 2076-0817 | 10 | 10 | SCIE | MICROBIOLOGY | 2021 | 4.531 | 42.0 | 0.53 | 2025-07-30 | 6 | 7 | spiramycin; HPLC; pharmacokinetics; withdrawal time; pharmacodynamics | PROTEIN-BINDING; PHARMACOKINETICS; GALLISEPTICUM; RESIDUES; BIOAVAILABILITY; TISSUE; PHARMACODYNAMICS; MACROLIDES; TYLOSIN; PLASMA | HPLC; Pharmacodynamics; Pharmacokinetics; Spiramycin; Withdrawal time | acetonitrile; ammonium acetate; chloroform; hexane; mayco pira; methanol; phosphoric acid; spiramycin; analytical parameters; animal experiment; animal tissue; antimicrobial activity; Article; bacterial strain; chicken; colony forming unit; controlled study; drug bioavailability; female; high performance liquid chromatography; limit of detection; limit of quantitation; linearity; male; minimum inhibitory concentration; Mycoplasma synoviae; Mycoplasma synoviae infection; nonhuman; pharmacodynamics; plasma concentration-time curve; protein binding; range; sensitivity analysis; single drug dose; time to maximum plasma concentration | English | 2021 | 2021-10 | 10.3390/pathogens10101238 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Successful Eradication of Porcine Epidemic Diarrhea in an Enzootically Infected Farm: A Two-Year Follow-Up Study | Porcine epidemic diarrhea virus (PEDV) has negatively affected the welfare of animals and their productivity in South Korea for three decades. A shortage of effective control measures has led to the virus becoming endemic in domestic pig populations. This study aimed to describe how our intervention measures were implemented for PEDV elimination in an enzootically infected farm. We operated a risk assessment model of PEDV recurrence to obtain information about the virus itself, herd immunity, virus circulation, and biosecurity at the farm. Next, we conducted a four-pillar-based two-track strategy to heighten sow immunity and eradicate the virus, with longitudinal monitoring of immunity and virus circulation, involving strict biosecurity, prime-boost pre-farrow L/K/K immunization, all-in-all-out and disinfection practices in farrowing houses, and disinfection and gilt management in wean-to-finish barns. In particular, we observed a high prevalence and long-term survival of PEDV in slurries, posing a critical challenge to PED eradication and highlighting the necessity for consecutive testing of barn slurry samples and for the management of infected manure to control PEDV. Genetic analysis of PEDVs in this farm indicated that genetic drift continued in the spike gene, with a substitution rate of 1.683 x 10(-4) substitutions/site/year. Our study underlines the need for active monitoring and surveillance of PEDV in herds and their environments, along with the coordinated means, to eliminate the virus and maintain a negative herd. The tools described in this study will serve as a framework for regional and national PED eradication programs. | Jang, Guehwan; Park, Jonghyun; Lee, Changhee | Kyungpook Natl Univ, Sch Life Sci, Anim Virol Lab, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea | 56608747100; 57210160562; 55700560700 | wayyonim12@naver.com;man3807@naver.com;changhee@knu.ac.kr; | PATHOGENS | PATHOGENS | 2076-0817 | 10 | 7 | SCIE | MICROBIOLOGY | 2021 | 4.531 | 42.0 | 1.06 | 2025-07-30 | 18 | 17 | biosecurity; endemic infection; eradication; herd immunity; monitoring and surveillance; prime-boost vaccination; PEDV | COMPLETE GENOME SEQUENCE; VIRUS PEDV; IMMUNOGENICITY; STRATEGIES; ANTIBODIES; EFFICACY; SERUM | Biosecurity; Endemic infection; Eradication; Herd immunity; Monitoring and surveillance; PEDV; Prime-boost vaccination | article; biosecurity; controlled study; disinfection; follow up; genetic analysis; genetic drift; herd immunity; immunization; long term survival; manure; nonhuman; piglet; Porcine epidemic diarrhea virus; prevalence; risk assessment; spike; vaccination; weaning | English | 2021 | 2021-07 | 10.3390/pathogens10070830 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Biapenem reduces sepsis mortality via barrier protective pathways against HMGB1-mediated septic responses | Background As a late mediator of sepsis, the role of high mobility group box 1 (HMGB1) has been recognized as important, and suppression of HMGB1 release and restoration of vascular barrier integrity are regarded as potentially promising therapeutic strategies for sepsis. For repositioning of previously FDA-approved drugs to develop new therapies for human diseases, screening of chemical compound libraries, biological active, is an efficient method. Our study illustrates an example of drug repositioning of Biapenem (BIPM), a carbapenem antibiotic, for the modulation of HMGB1-induced septic responses. Methods We tested our hypothesis that BIPM inhibits HMGB1-induced vascular hyperpermeability and thereby increases the survival of septic mouse model from suppression of HMGB1 release upon lipopolysaccharide (LPS)-stimulation. In LPS-activated human umbilical vein endothelial cells (HUVECs) and a cecal ligation and puncture (CLP)-induced sepsis mouse model, antiseptic activity of BIPM was investigated from suppression of vascular permeability, pro-inflammatory proteins, and markers for tissue injury. Results BIPM significantly suppressed release of HMGB1 both in LPS-activated HUVECs (upto 60%) and the CLP-induced sepsis mouse model (upto 54%). BIPM inhibited hyperpermeability (upto 59%) and reduced HMGB1-mediated vascular disruptions (upto 62%), mortality (upto 50%), and also tissue injury including lung, liver, and kidney in mice. Conclusion Reduction of HMGB1 release and septic mortality by BIPM (in vitro, from 5 to 15 mu M for 6 h; in vivo, from 0.37 to 1.1 mg/kg, 24 h) indicate a possibility of successful repositioning of BIPM for the treatment of sepsis. | Kim, Jaehong; Choo, Samyeol; Sim, Hyunchae; Baek, Moon-Chang; Bae, Jong-Sup | Gachon Univ, Coll Med, Dept Biochem, Incheon 21999, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, CMRI, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, CMRI, Dept Mol Med, Daegu 41944, South Korea | Kim, Jaehong/AAJ-2051-2020; Bae, Jong-Sup/AAU-9724-2020 | 55992306000; 57219092520; 57219098739; 7006013097; 16021543200 | baejs@knu.ac.kr; | PHARMACOLOGICAL REPORTS | PHARMACOL REP | 1734-1140 | 2299-5684 | 73 | 3 | SCIE | PHARMACOLOGY & PHARMACY | 2021 | 3.919 | 42.1 | 0.28 | 2025-07-30 | 6 | 3 | Biapenem; HMGB1; Endothelium; Sepsis | Biapenem; Endothelium; HMGB1; Sepsis | Animals; Cell Movement; Cells, Cultured; Disease Models, Animal; HMGB1 Protein; Human Umbilical Vein Endothelial Cells; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Sepsis; Signal Transduction; Thienamycins; biapenem; cell adhesion molecule; chemokine receptor CXCR1; chemokine receptor CXCR2; CXCL2 chemokine; endothelial leukocyte adhesion molecule 1; high mobility group B1 protein; immunoglobulin enhancer binding protein; intercellular adhesion molecule 1; interleukin 1beta; interleukin 6; interleukin 8; mitogen activated protein kinase 1; mitogen activated protein kinase 3; tumor necrosis factor; vascular cell adhesion molecule 1; zingerone; biapenem; high mobility group B1 protein; HMGB1 protein, human; lipopolysaccharide; thienamycin derivative; animal cell; animal experiment; animal model; animal tissue; antimicrobial activity; Article; blood vessel permeability; cecal ligation and puncture-induced sepsis; cell adhesion; controlled study; cytokine production; human; human cell; in vitro study; in vivo study; kidney injury; leukocyte migration; liver injury; lung injury; male; mortality; mouse; neutrophil; nonhuman; protein secretion; survival rate; umbilical vein endothelial cell; animal; C57BL mouse; cell culture; cell motion; disease model; drug effect; metabolism; mortality; sepsis; signal transduction | English | 2021 | 2021-06 | 10.1007/s43440-020-00212-0 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: