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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Towards spin quantum materials: Structure and potential energy profiles of weakly interacting arrays of iron porphyrin complexes at graphene armchair nanoribbon | The atomic structure, the rates of atomic spin polarization and potential energy profiles of heterostructure composed by iron porphyrin deposited on armchair graphene nanoribbon (FeP/AGNR) were investigated using density functional theory (DFT). The multiplicity of the Fe+2 ion in iron porphyrin for all possible types of coordination was determined as a triplet. Two possible 12 and 16 types of FeP coordination on AGNR were located with 0.43 and 0.15 kcal/mol forward and reversed potential barriers and 39% and 61% Arrhenius populations, respectively. It was found that FeP/AGNR can be used for perspective spin quantum applications due to localized spin-flip transition in IRA spectral region. | Melchakova, Iu; Kuklin, A.; Avramov, P. | Kyungpook Natl Univ, Dept Chem, Daegu, South Korea; Siberian Fed Univ, Dept Sci & Innovat, 79 Svobodny Pr, Krasnoyarsk 660041, Russia; Natl Res Tomsk State Univ, Tomsk 634050, Russia; KTH Royal Inst Technol, Sch Engn Sci Chem Biotechnol & Hlth, Div Theoret Chem & Biol, S-10691 Stockholm, Sweden | Melchakova, Iuliia/KGM-5967-2024; Kuklin, Artem/A-9007-2014 | 57206720228; 56035188600; 7004322420 | iuliia.melchakova@gmail.com;paul.veniaminovich@knu.ac.kr; | CHEMICAL PHYSICS LETTERS | CHEM PHYS LETT | 0009-2614 | 1873-4448 | 755 | SCIE | CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2020 | 2.328 | 47.3 | 0 | 2025-06-25 | 0 | 0 | Density functional theory; Graphene; Graphene nanoribbon; Molecular physics; Nanoribbons; Porphyrins; Potential energy; Spin polarization; Arrhenius; Atomic spin; Iron porphyrin; Localized spin; Potential barriers; Potential energy profiles; Quantum applications; Spectral region; Iron compounds | English | 2020 | 2020-09-16 | 10.1016/j.cplett.2020.137807 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Association between Breakfast Skipping and the Metabolic Syndrome: The Korea National Health and Nutrition Examination Survey, 2017 | Background and Objectives:Recently, the prevalence of metabolic syndrome in Korea has increased rapidly. Current knowledge reflects the importance of dietary control in relation to the metabolic syndrome. The objective of this study was to evaluate the influence of skipping breakfast on the metabolic syndrome.Materials and Methods:We conducted a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey 2017 for the second year. A total of 3864 adults aged 20 to 64 were included in the study. We stratified the study population into three groups, based on breakfast patterns: the regular group, irregular group, and skipping group. Multiple logistic regression analysis was used to analyze the association between skipping breakfast and the presence of metabolic syndrome.Results:We noted an increase in the proportion of metabolic syndrome cases as follows: skipping group (3.3%), irregular group (5.4%), and regular group (8.5%) (p< 0.001). The multivariate-adjusted odds ratios of metabolic syndrome in the skipping and irregular groups compared with the regular group were 0.68 (95% CI; 0.35 to 1.35) and 0.81 (95% CI; 0.51 to 1.28), respectively. In the 40-65-year-old age group, which had a high prevalence of metabolic syndrome, the multivariate-adjusted odds ratios of metabolic syndrome in the skipping group compared with regular group were 0.78 (95%CI, 0.39 to 1.62).Conclusions:There was no significant correlation between skipping breakfast and risk factors of metabolic syndrome (after adjusting for risk factors), but a tendency of skipping breakfast to lower the risk of metabolic syndrome was observed. A rationale for these results is proposed through the association between skipping breakfast and intermittent fasting. | Jung, JaeHun; Kim, A-Sol; Ko, Hae-Jin; Choi, Hye-In; Hong, Hee-Eun | Kyungpook Natl Univ Hosp, Dept Family Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Family Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Family Med, Chilgok Hosp, Daegu 41404, South Korea | ; JUNG, JAEHUN/KHE-5939-2024 | 57218324217; 57203290656; 54393415700; 57202001023; 57218525734 | zeuse0258@naver.com;deepai@knu.ac.kr;liveforme@knu.ac.kr;blbr20@naver.com;hhe8824@naver.com; | MEDICINA-LITHUANIA | MEDICINA-LITHUANIA | 1010-660X | 1648-9144 | 56 | 8 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.43 | 47.6 | 0.72 | 2025-06-25 | 15 | 13 | skipping breakfast; metabolic syndrome; Korea National Health and Nutrition Examination Survey; intermittent fasting | RISK-FACTORS; CALORIC RESTRICTION; FREQUENCY; OBESITY; PREVALENCE; QUALITY | Intermittent fasting; Korea National Health and Nutrition Examination Survey; Metabolic syndrome; Skipping breakfast | Adult; Breakfast; Correlation of Data; Cross-Sectional Studies; Fasting; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Nutrition Surveys; Republic of Korea; Risk Factors; adult; adverse event; cross-sectional study; diet restriction; female; human; male; meal; metabolic syndrome X; middle aged; nutrition; pathophysiology; physiology; risk factor; South Korea | English | 2020 | 2020-08 | 10.3390/medicina56080396 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Obstruction of the Hepatic Venous Flow Caused by Intravenous Leiomyomatosis | Budd-Chiari syndrome (BCS) is a rare intrahepatic vascular disease that is characterized by a hepatic venous outflow obstruction. Intravenous leiomyomatosis (ILs) is a rare complication of a myoma. Here, we report a case of BCS that was caused by intracaval ILs. A woman presented to the emergency department (ED) with abdominal distension that had gradually progressed over a period of 3 years. Bedside ultrasonography and contrast-enhanced computed tomography (CECT) showed a large ascites and pelvic mass. The mass continued to the inferior vena cava and the right atrium. The intracaval mass was obstructing the left and middle hepatic veins. We established a tentative diagnosis of BCS caused by intracaval ILs and attempted surgical resection. Complete resection of the intracaval mass failed because of adhesion; however, she was discharged from the hospital without any postoperative complications. After 3 months, a pelvic ultrasonography showed a recurrence of a 4 x 3 cm pelvic mass. The mass size increased to 6 cm after 30 months. ILs can cause secondary BCS and can lead to life-threatening conditions. Owing to its extreme rarity, early detection in the ED is challenging. Bedside ultrasonography and CECT can enable the early recognition of BCS by ILs. | Park, Sin-Youl; Yeo, In Hwan; Kim, Yun Jeong; Kim, Jong Kun | Yeungnam Univ, Coll Med, Dept Emergency Med, Daegu 42415, South Korea; Kyungpook Natl Univ, Dept Emergency Med, Sch Med, Daegu 41404, South Korea | Yeo, Inhwan/GXZ-7024-2022; Kim, Joo/JAZ-0897-2023 | 56184913500; 57216816807; 57202340666; 55915816900 | dryuri@naver.com;inani@hanmail.com;kimyjem1@gmail.com;kim7155@knu.ac.kr; | MEDICINA-LITHUANIA | MEDICINA-LITHUANIA | 1010-660X | 1648-9144 | 56 | 12 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.43 | 47.6 | 0.08 | 2025-06-25 | 4 | 3 | Budd– Chiari syndrome; Inferior vena cava; leiomyoma; leiomyomatosis; ultrasonography | BUDD-CHIARI-SYNDROME; SMOOTH-MUSCLE TUMORS; INFERIOR VENA-CAVA; DIAGNOSIS; EXTENSION; UTERUS; VEIN | Budd–Chiari syndrome; Inferior vena cava; Leiomyoma; Leiomyomatosis; Ultrasonography | Budd-Chiari Syndrome; Female; Humans; Leiomyomatosis; Neoplasm Recurrence, Local; Ultrasonography; Vena Cava, Inferior; Budd Chiari syndrome; case report; diagnostic imaging; echography; female; human; inferior cava vein; leiomyomatosis; tumor recurrence | English | 2020 | 2020-12 | 10.3390/medicina56120696 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Sargassum miyabei Yendo Brown Algae Exert Anti-Oxidative and Anti-AdipogenicEffects on 3T3-L1 Adipocytes by Downregulating PPARγ | Background and objectives: Sargassum miyabei Yendo, belonging to the family Sargassaceae, has been reported to have various biological effects such as anti-tyrosinase activity and anti-inflammation. However, the anti-obesity effect of Sargassum miyabei Yendo has not yet been reported. Materials and Methods: The effects of Sargassum miyabei Yendo extract (SME) on 3T3-L1 adipocytes were screened by3-(4,5)-dimethylthiazo-2-yl-2,5-diphenyltetrazolium bromide (MTT), Oil red O staining, western blot, and Real-time reverse transcription polymerase chain reaction analyses. Results: Here, we show that SME had potent 2,2'-azinobis-3-ehtlbezothiazoline-6-sulfonic acid radical decolorization (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant activity with half maximal inhibitory concentration (IC50) value of 0.2868 +/- 0.011 mg/mL and 0.2941 +/- 0.014 mg/mL, respectively. In addition, SME significantly suppressed lipid accumulation and differentiation of 3T3-L1 preadipocytes, as shown by Oil Red O staining results. SME attenuated the expression of adipogenic- and lipogenic-related genes such as peroxisome proliferator-activated receptor gamma (PPAR gamma), CCAAT-enhancer-binding protein alpha (C/EBP alpha), CCAAT-enhancer-binding protein delta (C/EBP delta), adiponectin, adipose triglyceride lipase (ATGL), fatty acid synthase (FAS), hormone-sensitive lipase (HSL), and lipoprotein lipase (LPL). Conclusions: These findings suggest that SME may have therapeutic implications for developing a new anti-obesity agent. | Kim, Dong Se; Lee, Seul Gi; Kim, Minyoul; Hahn, Dongyup; Jung, Sung Keun; Cho, Tae Oh; Nam, Ju-Ock | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Chosun Univ, Dept Life Sci, Gwangju 501759, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Inst Agr Sci & Technol, Daegu 41566, South Korea | Oh, Tae/KIJ-2380-2024; Jung, SUNG KEUN/AGR-2623-2022 | 57220072584; 56995397800; 57209449244; 36554163400; 35310491400; 7202393883; 7201496105 | aodydirk@naver.com;lsg100479@knu.ac.kr;rlaalsduf2@naver.com;dohahn@knu.ac.kr;skjung04@knu.ac.kr;tocho@chosun.ac.kr;namjo@knu.ac.kr; | MEDICINA-LITHUANIA | MEDICINA-LITHUANIA | 1010-660X | 1648-9144 | 56 | 12 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.43 | 47.6 | 0.4 | 2025-06-25 | 5 | 6 | Sargassum miyabei Yendo; brown algae; obesity; lipid accumulation | CELLULAR-MODELS; OBESITY; DIFFERENTIATION; ADIPOGENESIS; DYSFUNCTION | 3T3-L1; Brown algae; Lipid accumulation; Obesity; Sargassum miyabei Yendo | 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Humans; Mice; Phaeophyta; PPAR gamma; Sargassum; peroxisome proliferator activated receptor gamma; 3T3-L1 cell line; adipocyte; animal; brown alga; cell differentiation; genetics; human; mouse; Sargassum | English | 2020 | 2020-12 | 10.3390/medicina56120634 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | SOLVENT-FREE ACETYLATION OF CNFS AND CMFS USING DIFFERENT CATALYSTS | Nanocellulose has several advantages, including hydrophilicity, low density, high strength property, and large specific-surface area. However, its hydrophilicity becomes a problem when it comes in contact with a polymer matrix in nanocomposites. Therefore, the transformation of hydrophilicity into hydrophobicity through chemical modifications is important. This study focused on the impacts of two solvent-free acetylation methods using iodine (Method 1) and sulfuric acid (Method 2) as catalysts. Moreover, herein, the characteristics of acetylated cellulose nanofibrils (A-CNFs) and cellulose microfibrils (A-CMFs) produced via an aqueous counter collision (ACC) are compared. The degree of substitution (DS) of acetylated samples increased with the reaction time. Furthermore, the DS of Method 2 was higher than that of Method 1. After acetylation, the X-ray diffraction patterns of the samples were semicrystalline and amorphous owing to the destruction of crystalline cellulose. Moreover, the crystallinity of all acetylated samples decreased. Excluding a few cases of Method 2, the thermal stability increased after acetylation. Excluding the CMFs treated with Method 2, the contact angle increased with the reaction time. This indicates that the samples were transformed to exhibit hydrophobic surfaces. In addition, the cases of Method 1 exhibited higher crystallinity, thermal stability, and wettability than those of Method 2. | Park, Seongsu; Park, Byung-Dae; Jung, Young Hoon | Kyungpook Natl Univ, Dept Wood Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Jung, Young/F-1703-2013; Park, Byung-Dae/ABB-1934-2020 | 57220771754; 7402834820; 55550063700 | byungdae@knu.ac.kr; | CELLULOSE CHEMISTRY AND TECHNOLOGY | CELL CHEM TECHNOL | 0576-9787 | 54 | 9-10 | SCIE | MATERIALS SCIENCE, PAPER & WOOD | 2020 | 1.467 | 47.7 | 0.08 | 2025-06-25 | 4 | 4 | solvent-free acetylation; CNFs; CMFs | CELLULOSE-ACETATE; HYDROLYSIS; BEHAVIOR | CMFs; CNFs; Solvent-free acetylation | Catalysts; Cellulose; Contact Angle; Crystallinity; Water Repellence; Wettability; Catalysts; Cellulose; Cellulose nanocrystals; Chemical modification; Contact angle; Crystallinity; Hydrophilicity; Hydrophobicity; Polymer matrix composites; Surface chemistry; Thermodynamic stability; Cellulose microfibrils; Cellulose nanofibrils; Crystalline cellulose; Degree of substitution; High strength; Hydrophobic surfaces; Large specific surface areas; Semicrystallines; Acetylation | English | 2020 | 2020 (SEP-DEC) | 10.35812/cellulosechemtechnol.2020.54.83 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | B2O3-Bi2O3-TeO2-BaO and TeO2-Bi2O3-BaO glass systems: a comparative assessment of gamma-ray and fast and thermal neutron attenuation aspects | For Pb-free 35B(2)O(3)35Bi(2)O(3)(30-x)TeO2(x)BaO (x=5, 10, 15, 20, and 25 mol%) and (90-x)TeO(2)10Bi(2)O(3)(x)BaO (x=10, 15, and 20 mol%) glass systems, gamma and neutron (both fast and thermal neutron) radiation shielding features were examined and compared. Within 0.015-15 MeV photon energy, mass attenuation coefficients (mu/rho), for all samples, which have been assessed using WinXCOM program are in fair agreement with deduced MCNP5 simulation code mu/rho results. For all selected samples, at the lowest energy, mu/rho has bigger values whereas at higher energy regions possess lower values. Furthermore, by employing mu/rho values, effective atomic number (Z(eff)), effective electron density (N-eff), half-value layer (HVL), tenth-value layer (TVL), and mean free path (MFP) are figured out for both glass systems. For studied samples, with the gradual replacement of TeO2 content with BaO, the derived values of Z(eff), HVL, TVL, and MFP revealed improved gamma -ray shielding potentiality. Besides, within photon energy range of 0.015-15 MeV, exposure build-up factors (EBFs) and energy absorption build-up factors (EABFs) were estimated for all samples by utilizing GP fitting method as a function of different penetration depths (0.5, 1, 2, 3, 4, 5, 6, 7, 8, 10, 15, 20, 25, 30, 35, and 40 mfp). The 35B(2)O(3)-35Bi(2)O(3)-5TeO(2)-25BaO (mol%) glass relatively larger mu/rho and Z(eff) values, lower HVL, TVL, and MFP values, and minimal EBF and EABF values confirm its superior gamma -ray attenuation competence among all samples. Additionally, in comparison, HVL and MFP values of 35B(2)O(3)-35Bi(2)O(3)-5TeO(2)-25BaO (mol%) sample are lower than the respective values of some commercial gamma -ray shielding glasses and different types of standard concretes, signifying its better shielding features than them. Moreover, macroscopic removal cross-section for fast neutrons (Sigma (R)), coherent scattering cross-section (sigma (cs)), incoherent scattering cross-section (sigma (ics)), absorption cross-section (sigma (A)), and total cross-section (sigma (T)) for thermal neutrons absorption were derived for both glass systems. Among all selected glasses, 35B(2)O(3)-35Bi(2)O(3)-5TeO(2)-25BaO (mol%) sample possesses relatively higher Sigma (R) (0.106 cm(-1)) and 'sigma (T)' (8.809 cm(-1) at 0.0253 eV neutron energy) values for fast and thermal neutrons attenuation, respectively, demonstrating its favorable absorption capability for neutrons. | Lakshminarayana, G.; Dong, M. G.; Al-Buriahi, M. S.; Kumar, Ashok; Lee, Dong-Eun; Yoon, Jonghun; Park, Taejoon | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Northeastern Univ, Dept Resource & Environm, Shenyang 110819, Peoples R China; Sakarya Univ, Dept Phys, Sakarya, Turkey; Univ Coll, Dept Phys, Dhuri, Punjab, India; Kyungpook Natl Univ, Sch Architecture & Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Hanyang Univ, Dept Mech Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea; Hanyang Univ, Dept Robot Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea | ; Gandham, Lakshminarayana/AAU-6162-2020; Kumar, Ashok/A-7742-2012; Al-Buriahi, M.S./HKW-2385-2023; DONG, Mengge/AEN-2933-2022 | 57194637883; 56082379700; 57191693608; 57307625500; 56605563300; 56449838900; 55717001200 | gandham@knu.ac.kr;dolee@knu.ac.kr;yooncsmd@gmail.com;taejoon@hanyang.ac.kr; | APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING | APPL PHYS A-MATER | 0947-8396 | 1432-0630 | 126 | 3 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2020 | 2.584 | 47.8 | 3.26 | 2025-06-25 | 84 | 90 | Barium bismuth borotellurite glass; Barium bismuth tellurite glass; WinXCOM; MCNP5; Mass attenuation coefficient; Radiation shielding effectiveness | RADIATION SHIELDING PARAMETERS; FEATURES; BORATE; PROGRAM; COEFFICIENTS; WINXCOM | Barium bismuth borotellurite glass; Barium bismuth tellurite glass; Mass attenuation coefficient; MCNP5; Radiation shielding effectiveness; WinXCOM | Atoms; Bismuth compounds; Coherent scattering; Electromagnetic wave attenuation; Gamma rays; Glass; Incoherent scattering; Neutron irradiation; Neutron logging; Neutrons; Photons; Radiation shielding; Tellurium compounds; Bismuth tellurite; Mass attenuation coefficients; MCNP5; Shielding effectiveness; WinXCOM; Barium compounds | English | 2020 | 2020-02-17 | 10.1007/s00339-020-3372-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Fabrication of AlGaN/GaN MISHEMT with dual-metal gate electrode and its performances | In this study, we investigated AlGaN/GaN metal-insulator-semiconductor high-electron-mobility transistors (MISHEMTs) with single-metal gate (SMG) and dual-metal gate (DMG) structures through experimental measurements and technology computer-aided design simulation. The DMG structure consists of nickel (Ni) in the source-side gate and titanium (Ti) in the drain-side gate metals for the distribution of an electric field. The measurement results demonstrate that the fabricated AlGaN/GaN DMG-MISHEMT produces improved device performances; this includes higher drain current (I-D), higher transconductance (g(m)), and higher breakdown voltage than the SMG-MISHEMT. The improvement is due to the distribution of an electric field. In addition, in terms of current collapse characteristics, the DMG-MISHEMT exhibited a small change rate in I-D at various quiescent bias points. These results mean that a DMG structure leads to excellent electrical characteristics. | Jung, Jun Hyeok; Cho, Min Su; Jang, Won Douk; Lee, Sang Ho; Jang, Jaewon; Bae, Jin-Hyuk; Yoon, Young Jun; Kang, In Man | Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; KIST, Brain Sci Inst, Ctr BioMicroSyst, Seoul 02792, South Korea | Lee, Sang Ho/MCX-8396-2025 | 57199984260; 57188742288; 57211978212; 57416738400; 57194107504; 35326180700; 55517032200; 7203062678 | yjyoon1213@gmail.com;imkang@ee.knu.ac.kr; | APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING | APPL PHYS A-MATER | 0947-8396 | 1432-0630 | 126 | 4 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2020 | 2.584 | 47.8 | 0.49 | 2025-06-25 | 18 | 17 | Gallium nitride (GaN); Dual-metal gate (DMG); High-electron-mobility transistor (HEMT); 2D technology computer-aided design (TCAD) | VOLTAGE; DEVICES | 2D technology computer-aided design (TCAD); Dual-metal gate (DMG); Gallium nitride (GaN); High-electron-mobility transistor (HEMT) | Aluminum gallium nitride; Computer circuits; Drain current; Electric fields; Electric insulators; Electron mobility; Electronic design automation; Fabrication; Gallium nitride; III-V semiconductors; Metals; Refractory metal compounds; Single electron transistors; Wide band gap semiconductors; Current collapse; D technologies; Device performance; Dual metal gate; Electrical characteristic; Gallium nitrides (GaN); High electron mobility transistor (HEMT); Technology computer aided design; High electron mobility transistors | English | 2020 | 2020-03-16 | 10.1007/s00339-020-3453-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | In vivo hydroxyapatite scaffold performance in infected bone defects | Critically sized bone defects are often compounded by infectious complications. The standard of care consists of bone autografts with systemic antibiotics. These injuries and treatments lead to donor site morbidity, antibiotic resistant strains of bacteria, and often end stage amputation. This study proposes an alternative to the autograft using a porous, hydroxyapatite (HA) scaffold evaluated with and without infection and antibiotics. Twenty-four New Zealand white rabbits received either our HA scaffold or a pulverized autograft (PBA) within a surgically created critical-sized defect in the femur. The two grafts were evaluated in either septic or aseptic defects and with or without antibiotic treatment. The HA scaffolds were characterized with micro computed tomography. Post-euthanasia, micro computed tomography, histology, and white blood cells component analysis were completed. The HA had significantly greater (p < .001) mineralization to total volume than the PBA groups with 27.56% and 14.88%, respectively, and the septic HA groups were significantly greater than the aseptic groups both with and without antibiotics (p = .016). The bone quality denoted by bone mineral density was also significantly greater (p < .001) in the HA groups (67.01 +/- 0.38 mgHA/cm(3)) than the PBA groups (64.66 +/- 0.85 mgHA/cm(3)). The HA scaffold is a viable alternative to the bone autograft in defects with and without infection as shown by the quality and quantity of bone. | Pearson, Joseph J.; Gerken, Nicholas; Bae, Chunsik; Lee, Kyu-Bok; Satsangi, Arpan; McBride, Sean; Appleford, Mark R.; Dean, David D.; Hollinger, Jeffrey O.; Ong, Joo L.; Guda, Teja | Univ Texas San Antonio, Dept Biomed Engn, One UTSA Circle,AET 1-356, San Antonio, TX 78249 USA; UTSA UTHSCSA Joint Grad Program Biomed Engn, San Antonio, TX USA; Univ Texas Hlth Sci Ctr San Antonio, Dept Orthopaed, San Antonio, TX 78229 USA; Chonnam Natl Univ, Coll Vet Med, Gwangju, South Korea; Kyungpook Natl Univ, Dept Prosthodont, Daegu, South Korea; Carnegie Mellon Univ, Bone Tissue Engn Ctr, Dept Biomed Engn, Pittsburgh, PA 15213 USA | Guda, Teja/A-7286-2009 | 57201617881; 54389092300; 55779077300; 15925571200; 6602605389; 57197472941; 16038756700; 7402370280; 57226205466; 7103112722; 24729017500 | teja.guda@utsa.edu; | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS | J BIOMED MATER RES B | 1552-4973 | 1552-4981 | 108 | 3 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2020 | 3.368 | 47.8 | 1.09 | 2025-06-25 | 26 | 28 | bone graft; calcium phosphate(s); hydroxyapatite; infection | SEGMENTAL DEFECT; VANCOMYCIN; OSTEOMYELITIS; IMPLANTS; RABBIT; ANTIBIOTICS; INHIBITION; RELEASE; GRAFT | bone graft; calcium phosphate(s); hydroxyapatite; infection | Animals; Autografts; Bone and Bones; Bone Density; Bone Regeneration; Bone Transplantation; Drug Resistance, Bacterial; Durapatite; Female; Femur; Osteomyelitis; Porosity; Rabbits; Regeneration; Tissue Engineering; Tissue Scaffolds; Wound Healing; X-Ray Microtomography; Antibiotics; Blood; Calcium phosphate; Computerized tomography; Defects; Hydroxyapatite; antibiotic agent; hydroxyapatite; hydroxyapatite; Antibiotic treatment; Bone graft; Bone mineral density; Component analysis; Critical sized defects; infection; Microcomputed tomography; New Zealand White rabbit; amputation; animal cell; animal experiment; animal model; animal tissue; antibiotic therapy; Article; bone defect; bone density; bone graft; bone mineralization; bone regeneration; bone volume; controlled study; donor site; erythrocyte; female; femur; granulocyte; histology; iliac crest; immune response; in vivo study; leukocyte count; lymphocyte; methicillin susceptible Staphylococcus aureus; micro-computed tomography; monocyte; nonhuman; ossification; pore size; porosity; rabbit model; surface area; trabecular bone; trabecular thickness; animal; antibiotic resistance; autograft; bone; bone transplantation; chemistry; Leporidae; osteomyelitis; pathology; procedures; regeneration; tissue engineering; tissue scaffold; wound healing; Bone | English | 2020 | 2020-04 | 10.1002/jbm.b.34466 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Li2O-B2O3-Bi2O3 glasses: gamma-rays and neutrons attenuation study using ParShield/WinXCOM program and Geant4 and Penelope codes | For 25 Li2O-(75-x) B2O3-x Bi2O3 (where x=0, 5, 10, 15, 20, 25, 30, 35, and 40 mol%) glasses, gamma-ray and neutrons attenuation features were explored by theoretical approach using ParShield/WinXCOM program, Geant4, and Penelope codes. At Ba-133 (276, 303, 356, and 384 keV), Na-22 (511 and 1280 keV), Cs-137 (662 keV), Mn-54 (835 keV), and Co-60 (1170 and 1330 keV) photon peaks, for all samples, mass attenuation coefficient (mu/rho), effective atomic number (Z(eff)), effective electron density (N-eff), half-value layer (HVL), and mean free path (MFP) parameters have been evaluated using ParShield/WinXCOM program. The mu/rho values computed by WinXCOM, Geant4, and Penelope codes were compared to check the accuracy, and satisfactory agreement among the values was identified. Moreover, using G-P fitting method as a function of penetration depth (1, 5, 10, 15, 20, 25, 30, 35, and 40 mfp) within the photon energy range of 0.015-15 MeV, exposure buildup factor (EBF) and energy absorption buildup factor (EABF) were derived. For all selected glasses, the effectiveness of the neutrons attenuation has been discussed in terms of macroscopic effective removal cross-section (Sigma (R)), coherent scattering cross-section (sigma (cs)), incoherent scattering cross-section (sigma (ics)), absorption cross-section (sigma (A)), and total neutron cross-section (sigma (T)). The 'sigma (T)' values have been calculated within 10(-4)-10(-8) MeV neutron energy range using the Geant4 code. The mu/rho possessed larger values at the lowest energy and lower values at higher energy regions for all studied glasses. The mu/rho, Z(eff), HVL, and MFP values showed enhanced gamma -ray shielding capability with Bi2O3 content increment in the samples. The 25 Li2O-35 B2O3-40 Bi2O3 (mol%) sample by having larger Z(eq) and/or Z(eff) value, faired lower EBF and EABF values. Largest mu/rho and Z(eff), and minimal HVL, MFP, EBF, and EABF values of 25 Li2O-35 B2O3-40 Bi2O3 (mol%) glass demonstrated its superior gamma -ray attenuation ability among all examined glasses. Further, among all glasses, 25 Li2O-75 B2O3 (mol%) sample exhibits relatively higher Sigma (R) (0.11326 cm(-1)) and 'sigma (T)' (46.109 cm(-1)-> 0.84607 cm(-1) from 1x10(-8) MeV -> 1x10(-4) MeV neutron energy) values for fast and thermal neutrons attenuation, respectively, indicating its better neutrons absorption competence. | Lakshminarayana, G.; Elmahroug, Y.; Kumar, Ashok; Dong, M. G.; Lee, Dong-Eun; Yoon, Jonghun; Park, Taejoon | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, Daegu 41566, South Korea; Univ Tunis El Manar, Fac Sci Tunis, Unite Rech Phys Nucl & Hautes Energies, Tunis 2092, Tunisia; Univ Cent, Ecole Cent Polytech Privee Tunis, Tunis, Tunisia; Univ Coll, Dept Phys, Benra Dhuri, Punjab, India; Northeastern Univ, Dept Resource & Environm, Shenyang 110819, Peoples R China; Kyungpook Natl Univ, Sch Architecture & Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Hanyang Univ, Dept Mech Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea; Hanyang Univ, Dept Robot Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea | Kumar, Ashok/A-7742-2012; Gandham, Lakshminarayana/AAU-6162-2020 | 57194637883; 55869725500; 57307625500; 56082379700; 56605563300; 56449838900; 55717001200 | gandham@knu.ac.kr;dolee@knu.ac.kr;yooncsmd@gmail.com;taejoon@hanyang.ac.kr; | APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING | APPL PHYS A-MATER | 0947-8396 | 1432-0630 | 126 | 4 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2020 | 2.584 | 47.8 | 0.92 | 2025-06-25 | 16 | 17 | Lithium bismuth borate glass; ParShield; Geant4; Penelope; Mass attenuation coefficient; Total neutron cross-section | RADIATION SHIELDING PROPERTIES; BORATE GLASSES; OXIDE; PARAMETERS; MCNP5; MULTICOMPONENT; LITHIUM; SYSTEM; PHOTON | Geant4; Lithium bismuth borate glass; Mass attenuation coefficient; ParShield; Penelope; Total neutron cross-section | Atoms; Bismuth compounds; Coherent scattering; Electromagnetic wave attenuation; Glass; Incoherent scattering; Lithium compounds; Neutron scattering; Neutrons; Photons; Bismuth borate glass; Geant4; Mass attenuation coefficients; ParShield; PENELOPE; Total neutron cross-section; Gamma rays | English | 2020 | 2020-03-02 | 10.1007/s00339-020-3418-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Correction | Li2O-B2O3-Bi2O3 glasses: gamma-rays and neutrons attenuation study using ParShield/WinXCOM program and Geant4 and Penelope codes (vol 126, 249, 2020) | Lakshminarayana, G.; Elmahroug, Y.; Kumar, Ashok; Dong, M. G.; Lee, Dong-Eun; Yoon, Jonghun; Park, Taejoon | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Univ Tunis El Manar, Fac Sci Tunis, Unite Rech Phys Nucl & Hautes Energies, Tunis 2092, Tunisia; Univ Cent, Ecole Cent Polytech Privee Tunis, Tunis, Tunisia; Univ Coll, Dept Phys, Benra Dhuri, Punjab, India; Northeastern Univ, Dept Resource & Environm, Shenyang 110819, Peoples R China; Kyungpook Natl Univ, Sch Architecture & Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea; Hanyang Univ, Dept Mech Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea; Hanyang Univ, Dept Robot Engn, 55 Hanyangdaehak Ro, Ansan 15588, Gyeonggi Do, South Korea | Gandham, Lakshminarayana/AAU-6162-2020; DONG, Mengge/AEN-2933-2022; Kumar, Ashok/A-7742-2012 | 57194637883; 55869725500; 57307625500; 56082379700; 56605563300; 56449838900; 55717001200 | gandham@knu.ac.kr;dolee@knu.ac.kr;yooncsmd@gmail.com;taejoon@hanyang.ac.kr; | APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING | APPL PHYS A-MATER | 0947-8396 | 1432-0630 | 126 | 5 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2020 | 2.584 | 47.8 | 1.1 | 2025-06-25 | 2 | 2 | English | 2020 | 2020-04-10 | 10.1007/s00339-020-3447-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Simulation of capacitorless dynamic random access memory based on junctionless FinFETs using grain boundary of polycrystalline silicon | In this paper, we report a junctionless FinFET-based capacitor less dynamic memory by using three-dimensional technology computer-aided design simulations. To realize the 1T-DRAM, the proposed device has been designed as a structure in which a poly-si layer is deposited on the fins of a typical junctionless FinFET. Poly-si has one or more grain boundaries (GB). A GB contains multiple traps, and these traps generally degrade device performance. Also, when poly-si is grown and utilized in semiconductor devices, non-uniform GB is formed across the entire wafer. Therefore, devices manufactured using poly-si have different GBs for each device and the performance of devices fabricated on the same wafer is different. Therefore, it is essential to design a device that can operate normally regardless of GB. The 1T-DRAM proposed in this study was simulated with the existence of GB and the direction of GB differently. Finally, a device that operates normal memory regardless of GB was designed. According to the simulation results, the retention time of the proposed 1T-DRAM has a margin of more than 10 uA/um and a retention time of more than 64 ms, regardless of the presence or absence of GBs. | Cho, Min Su; Mun, Hye Jin; Lee, Sang Ho; Jang, Jaewon; Bae, Jin-Hyuk; Kang, In Man | Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea | Lee, Sang Ho/MCX-8396-2025 | 57188742288; 57219936994; 57416738400; 57194107504; 35326180700; 7203062678 | imkang@ee.knu.ac.kr; | APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING | APPL PHYS A-MATER | 0947-8396 | 1432-0630 | 126 | 12 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2020 | 2.584 | 47.8 | 0.33 | 2025-06-25 | 7 | 8 | Capacitorless; FinFET; Grain boundary; Junctionless; Polycrystalline silicon; 1T-DRAM | 1T-DRAM; TRANSISTORS | 1T-DRAM; Capacitorless; FinFET; Grain boundary; Junctionless; Polycrystalline silicon | Computer aided design; FinFET; Grain boundaries; Integrated circuit design; Polycrystalline materials; Silicon wafers; Capacitor-less; Capacitorless dynamic random access memory; Device performance; Dynamic memory; Multiple traps; Performance of devices; Retention time; Three dimensional technologies; Dynamic random access storage | English | 2020 | 2020-12 | 10.1007/s00339-020-04125-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Third-order nonlinear optical features of zirconia-added lead silicate glass ceramics embedded with Pb2Fe2O5 perovskite crystal phases and role of Fe ions | This study is aimed to identify the role of Fe2O3 in enhancing the efficiency of THG beam of Nd:YAG laser in lead zirconium silicate glass ceramics. The PbO-ZrO2-SiO2:Fe2O3 glass ceramics were synthesized by heat-treating the glasses for a prolonged time. XRD and SEM studies were performed to identify different crystalline phases in the samples. The SEM pictures have shown the presence of multiple crystallites of size in the range 0.1-0.6 mu m, while characterization by XRD technique indicated the glass ceramic samples consist of perovskite (Pb2Fe2O5)-O-III, (Fe2SiO4)-Si-II, crystal phases. These studies have also demonstrated that there is an enhancement in the concentration of Fe3+ (O-h) crystalline phases with increasing quantity of Fe2O3 in the samples. Spectroscopic investigations (viz., IR and optical absorption) have further reinforced the above result and additionally indicated an increased degree of internal chaos in the material. The intensity of third harmonic generation (THG) beam of Nd:YAG laser (lambda = 1064 nm) measured in the reflected regime after the pre-photopolarization of the samples indicated the largest intensity for the samples containing the highest concentration of Fe2O3. Thorough analysis of these results indicated that the tilted glass samples heat-treated with 0.5 mol% of Fe2O3 have significant chaotic internal structure and paved the way for obtaining intense THG signal with minimal phonon losses. Hence, such glass ceramics are predicted to be useful materials in the design of different optoelectronic devices. | Chandrakala, Ch; Reddy, A. Siva Sesha; Jedryka, J.; Kumar, Valluri Ravi; Raju, G. Naga; Venkatramaiah, N.; Kumar, V. Ravi; Lakshminarayana, G.; Veeraiah, N. | Acharya Nagarjuna Univ, Dept Phys, Guntur 522510, Andhra Pradesh, India; Czestochowa Tech Univ, Fac Elect Engn, Czestochowa, Poland; VFSTR Univ, Dept Phys, Guntur 522213, Andhra Pradesh, India; SRM Inst Sci & Technol, Dept Chem, Kattankulathur, Kanchipuram, India; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea | Nalluri, Veeraiah/L-4913-2015; Gandham, Lakshminarayana/AAU-6162-2020; Ravi Kumar, V./AAN-9727-2021; Siva Sesha Reddy, Dr. A./AAU-7385-2020; nutalapati, venkatramiah/C-7381-2009 | 57209879312; 56515304700; 55053482500; 57197697173; 9275540300; 23095936500; 57191254314; 57194637883; 7006347728 | gnaga9@gmail.com;nvr8@rediffmail.com; | APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING | APPL PHYS A-MATER | 0947-8396 | 1432-0630 | 126 | 6 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2020 | 2.584 | 47.8 | 0.6 | 2025-06-25 | 9 | 11 | Lead zirconium silicate glass ceramics; Pb2Fe2O5 perovskite crystal phases; Nd; YAG laser; THG studies | PHYSICAL-CHARACTERISTICS; DIELECTRIC-PROPERTIES; CRYSTALLIZATION; MICROSTRUCTURE; TRANSLUCENT | Lead zirconium silicate glass ceramics; Nd:YAG laser; Pb<sub>2</sub>Fe<sub>2</sub>O<sub>5</sub> perovskite crystal phases; THG studies | Absorption spectroscopy; Crystallites; Crystals; Glass ceramics; Hematite; Iron; Lead oxide; Light absorption; Nanocrystalline materials; Neodymium compounds; Neodymium lasers; Optoelectronic devices; Perovskite; Silica; Silicon; X ray diffraction; Yttrium aluminum garnet; Zircon; Zirconia; Concentration of fe; Crystalline phasis; Internal structure; Lead silicate glass; Perovskite crystal; Spectroscopic investigations; Third-order nonlinear optical; Zirconium silicate; Harmonic generation | English | 2020 | 2020-05-12 | 10.1007/s00339-020-03570-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Eriocitrin Improves Adiposity and Related Metabolic Disorders in High-Fat Diet-Induced Obese Mice | Eriocitrin (EC) is an abundant flavonoid in lemons, which is known as a strong antioxidant agent. This study investigated the biological and molecular mechanisms underlying the anti-obesity effect of EC in high-fat diet (HFD)-fed obese mice. C57BL/6N mice were fed an HFD (40 kcal% fat) with or without 0.005% (w/w) EC for 16 weeks. Dietary EC improved adiposity by increasing adipocyte fatty acid (FA) oxidation, energy expenditure, and mRNA expression of thermogenesis-related genes in brown adipose tissue (BAT) and skeletal muscle, whereas it also decreased lipogenesis-related gene expression in white adipose tissue. In addition to adiposity, EC prevented hepatic steatosis by diminishing lipogenesis while enhancing FA oxidation in the liver and fecal lipid excretion, which was linked to attenuation of hyperlipidemia. Moreover, EC improved insulin sensitivity by decreasing hepatic gluconeogenesis and proinflammatory responses. These findings indicate that EC may protect against diet-induced adiposity and related metabolic disorders by controlling thermogenesis of BAT and skeletal muscle, FA oxidation, lipogenesis, fecal lipid excretion, glucose utilization, and gluconeogenesis. | Kwon, Eun-Young; Choi, Myung-Sook | Kyungpook Natl Univ, Dept Food Sci & Nutr, Taegu 702701, South Korea; Kyungpook Natl Univ, Ctr Food & Nutr Genom Res, Daegu, South Korea | 15765422500; 7402093877 | mschoi@knu.ac.kr; | JOURNAL OF MEDICINAL FOOD | J MED FOOD | 1096-620X | 1557-7600 | 23 | 3 | SCIE | CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2020 | 2.786 | 47.9 | 1.48 | 2025-06-25 | 28 | 26 | adiposity; energy expenditure; eriocitrin; fatty acid oxidation; insulin resistance; NAFLD | INSULIN-RESISTANCE; GLUCOSE-PRODUCTION; LIVER; TISSUE; SARCOLIPIN; STEATOHEPATITIS; THERMOGENESIS | adiposity; energy expenditure; eriocitrin; fatty acid oxidation; insulin resistance; NAFLD | Adipose Tissue, Brown; Adiposity; Animals; Citrus; Diet, High-Fat; Flavanones; Lipogenesis; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle, Skeletal; Obesity; Phytotherapy; Plant Extracts; Thermogenesis; acetyl coenzyme A carboxylase; acyl coenzyme A desaturase 1; adipocytokine; antiobesity agent; beta 3 adrenergic receptor; carnitine palmitoyltransferase I; CD36 antigen; cholesterol; eriocitrin; fatty acid; feces lipid; flavonoid; gamma interferon; glucagon like peptide 1; insulin receptor substrate 2; interleukin 1beta; interleukin 6; leptin; lipoprotein lipase; malate dehydrogenase (decarboxylating); messenger RNA; monocyte chemotactic protein 1; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor gamma coactivator 1alpha; resistin; sterol regulatory element binding protein 1; triacylglycerol; tumor necrosis factor receptor superfamily member 6; unclassified drug; uncoupling protein 1; uncoupling protein 3; eriocitrin; flavanone derivative; plant extract; adipocyte; animal experiment; animal model; animal tissue; antiobesity activity; Article; biological activity; body fat; body weight loss; brown adipose tissue; cholesterol blood level; controlled study; COX8beta gene; diet-induced obesity; drug effect; drug efficacy; drug mechanism; dyslipidemia; energy expenditure; fatty acid oxidation; fatty liver; gene; gene expression; gluconeogenesis; glucose tolerance; glucose utilization; hyperlipidemia; inflammation; insulin resistance; insulin sensitivity; lemon; lipid diet; lipid liver level; lipogenesis; male; metabolic disorder; molecular biology; mouse; nonhuman; priority journal; SERCA1 gene; SERCA2 gene; skeletal muscle; SLN gene; thermogenesis; triacylglycerol blood level; white adipose tissue; animal; C57BL mouse; chemistry; Citrus; lipid diet; metabolism; mouse mutant; obesity; pathophysiology; phytotherapy | English | 2020 | 2020-03-01 | 10.1089/jmf.2019.4638 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fisetin Alleviates Hepatic and Adipocyte Fibrosis and Insulin Resistance in Diet-Induced Obese Mice | The present study aimed to investigate the protective role of the flavonoid fisetin (FI) on inflammation-mediated metabolic diseases, especially tissue fibrosis and insulin resistance (IR) in high-fat diet (HFD)-induced obese mice. C57BL/6J mice were fed with normal-fat diet, HFD (40 kcal% fat), or HFD +0.02% (w/w) FI for 16 weeks. Dietary FI supplementation improved hepatic steatosis by restricting lipogenesis, while promoting lipolysis in the liver. FI also prevented adiposity via an increase in the expression of genes involved in FA oxidation and a decrease in the expression of genes involved in lipogenesis in white adipose tissue. In addition, FI increased brown adipose tissue (BAT) and skeletal muscle weights, thermogenic gene mRNA expression in BAT, and tricarboxylic acid cycle-related gene expression in skeletal muscle, which may be linked to the prevention of nonalcoholic fatty liver disease as well as adiposity. Moreover, FI supplementation decreased excessive reactive oxygen species production by increasing paraoxonase activity, adipokine dysregulation, proinflammatory cytokine production, and extracellular matrix amassment in the liver. FI supplementation ameliorated IR, in part, by normalizing pancreatic islet dysfunction, and it declined hepatic gluconeogenesis and proinflammatory responses. Taken together, the present findings indicate that FI can protect against HFD-induced inflammation-mediated disorders, including fibrosis and IR. | Choi, Myung-Sook; Choi, Ji-Young; Kwon, Eun-Young | Kyungpook Natl Univ, Dept Food Sci & Nutr, 1370 Sank Yuk Dong, Daegu 41566, South Korea; Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul, South Korea | 7402093877; 57219113098; 15765422500 | eykwon@knu.ac.kr; | JOURNAL OF MEDICINAL FOOD | J MED FOOD | 1096-620X | 1557-7600 | 23 | 10 | SCIE | CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2020 | 2.786 | 47.9 | 1.02 | 2025-06-25 | 23 | 21 | adiposity; extracellular matrix; fisetin; insulin resistance; liver fibrosis; NAFLD | NONALCOHOLIC FATTY LIVER; ADIPOSE-TISSUE; MATRIX METALLOPROTEINASES; ASSAY; DISEASE; STEATOHEPATITIS; THERMOGENESIS; SARCOLIPIN; SUBSTRATE; REDUCTASE | Adiposity; Extracellular matrix; Fisetin; Insulin resistance; Liver fibrosis; NAFLD | Adipocytes; Adiposity; Animals; Diet, High-Fat; Flavonols; Insulin Resistance; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Mice, Obese; acetyl coenzyme A carboxylase; acyl coenzyme A desaturase; acyl coenzyme A desaturase 1; adipocytokine; adiponectin; aryldialkylphosphatase; beta 3 adrenergic receptor; carnitine palmitoyltransferase; collagen type 1; cytochrome c oxidase; fatty acid synthase; fisetin; G protein coupled receptor kinase 3; gamma interferon; gelatinase A; gelatinase B; glucokinase; glucose 6 phosphatase; glyceraldehyde 3 phosphate dehydrogenase; high density lipoprotein cholesterol; insulin receptor substrate 2; interleukin 6; leptin; messenger RNA; monocyte chemotactic protein 1; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor gamma; phosphatidate phosphatase; phosphoenolpyruvate carboxykinase (GTP); plasminogen activator inhibitor 1; reactive oxygen metabolite; sirtuin 1; sterol regulatory element binding protein 1; stromelysin; toll like receptor 4; transcription factor; transcription factor AP 1; tumor necrosis factor; fisetin; flavonol derivative; adipocyte; adipose tissue; animal cell; animal experiment; animal model; Article; brown adipose tissue; citric acid cycle; controlled study; cytokine production; diet-induced obesity; enzyme activity; extracellular matrix; gastrocnemius muscle; gene expression; gene expression level; high density lipoprotein cholesterol level; homeostasis model assessment; insulin resistance; light dark cycle; lipogenesis; liver fibrosis; male; mouse; nonhuman; priority journal; retroperitoneum; RNA isolation; room temperature; skeletal muscle; adipocyte; adverse event; animal; C57BL mouse; drug effect; insulin resistance; lipid diet; liver cirrhosis; mouse mutant; obesity; pathology | English | 2020 | 2020-10-01 | 10.1089/jmf.2019.4619 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fisetin Suppresses Pulmonary Inflammatory Responses through Heme Oxygenase-1 Mediated Downregulation of Inducible Nitric Oxide Synthase | The effects of a mixture of fisetin on cytokine-mediated pulmonary damages have not been studied, despite its known antiviral, neuroprotective, and anti-inflammatory activities. Using lipopolysaccharide (LPS)-activated human pulmonary artery endothelial cells (HPAECs), we determined the effects of fisetin on the induction of heme oxygenase-1 (HO-1), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). In the lung tissue of LPS-treated mice, fisetin was also evaluated for its effect on the regulation of iNOS and tumor necrosis factor (TNF)-alpha. In LPS-activated HPAECs, fisetin increased nuclear factor erythrocyte 2-related factor 2-antioxidant response element (Nrf2-ARE) reporter activity through the nuclear translocation of Nrf2, and the expression of HO-1, and decreased IL-1 beta and iNOS/NO production. In particular, the suppression of iNOS/NO expression by the administration of fisetin was dependent on HO-1. Current findings indicate that the anti-inflammatory activity of fisetin was due to its HO-1 dependent downregulation of p-STAT-1 and nuclear factor kappa B (NF-kappa B) and the resultant inhibition of iNOS, and also suggest TNF-alpha as a potential target for HO-1. We propose that administration of fisetin may be a novel approach, ideal for the treatment of inflammatory pulmonary disease. | Sim, Hyunchae; Choo, Samyeol; Kim, Jaehong; Baek, Moon-Chang; Bae, Jong-Sup | Kyungpook Natl Univ, BK21 Plus KNU Multiom Based Creat Drug Res Team, Res Inst Pharmaceut Sci, Coll Pharm,CMRI, 80 Daehak Ro, Daegu 41566, South Korea; Gachon Univ, Dept Biochem, Coll Med, Incheon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, CMRI, Daegu, South Korea | Kim, Jaehong/AAJ-2051-2020; Bae, Jong-Sup/AAU-9724-2020 | 57219098739; 57219092520; 55992306000; 7006013097; 16021543200 | baejs@knu.ac.kr; | JOURNAL OF MEDICINAL FOOD | J MED FOOD | 1096-620X | 1557-7600 | 23 | 11 | SCIE | CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2020 | 2.786 | 47.9 | 0.55 | 2025-06-25 | 11 | 11 | fisetin; HO-1; iNOS; p-STAT-1 | CARBON-MONOXIDE; KAPPA-B; RELEASE; INHIBITION; EXTRACT; COX-2; MODEL | fisetin; HO-1; iNOS; p-STAT-1 | Animals; Cells, Cultured; Cyclooxygenase 2; Down-Regulation; Endothelial Cells; Flavonols; Heme Oxygenase-1; Humans; Inflammation; Lipopolysaccharides; Lung; Membrane Proteins; Mice; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; STAT1 Transcription Factor; cyclooxygenase 2; fisetin; heme oxygenase 1; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; interleukin 1beta; lipopolysaccharide; nitric oxide; STAT1 protein; transcription factor Nrf2; tumor necrosis factor; cyclooxygenase 2; fisetin; flavonol derivative; heme oxygenase 1; HMOX1 protein, human; Hmox1 protein, mouse; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; membrane protein; NFE2L2 protein, human; nitric oxide; NOS2 protein, human; Nos2 protein, mouse; STAT1 protein; STAT1 protein, human; transcription factor Nrf2; animal experiment; animal tissue; antiinflammatory activity; antioxidant responsive element; Article; controlled study; cytokine production; down regulation; drug mechanism; endothelium cell; enzyme activity; human; human cell; lung parenchyma; male; mouse; nonhuman; pneumonia; priority journal; protein expression; pulmonary artery; animal; cell culture; cytology; drug effect; inflammation; lung; metabolism | English | 2020 | 2020-11-01 | 10.1089/jmf.2020.4755 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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