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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Clinical and Genetic Features of Korean Inherited Arrhythmia Probands | Background and Objectives: Inherited arrhythmia (IA) is a more common cause of sudden cardiac death in Asian population, but little is known about the genetic background of Asian IA probands. We aimed to investigate the clinical characteristics and analyze the genetic underpinnings of IA in a Korean cohort. Methods: This study was conducted in a multicenter cohort of the Korean IA Registry from 2014 to 2017. Genetic testing was performed using a next-generation sequencing panel including 174 causative genes of cardiovascular disease. Results: Among the 265 IA probands, idiopathic ventricular fibrillation (IVF) and Brugada Syndrome (BrS) was the most prevalent diseases (96 and 95 cases respectively), followed by long QT syndrome (LQTS, n=54). Two-hundred-sixteen probands underwent genetic testing, and 69 probands (31.9%) were detected with genetic variant, with yield of pathogenic or likely pathogenic variant as 6.4%. Left ventricular ejection fraction was significantly lower in genotype positive probands (54.7 +/- 11.3 vs. 59.3 +/- 9.2%, p=0.005). IVF probands showed highest yield of positive genotype (54.0%), followed by LQTS (23.8%), and BrS (19.5%). Conclusions: There were significant differences in clinical characteristics and genetic yields among BrS, LQTS, and IVF. Genetic testing did not provide better yield for BrS and LQTS. On the other hand, in IVF, genetic testing using multiple gene panel might enable the molecular diagnosis of concealed genotype, which may alter future clinical diagnosis and management strategies. | Jeong, Joo Hee; Oh, Suk-Kyu; Kim, Yun Gi; Choi, Yun Young; Lee, Hyoung Seok; Shim, Jaemin; Park, Yae Min; Kim, Jun-Hyung; Oh, Yong-Seog; Kim, Nam-Ho; Pak, Hui-Nam; On, Young Keun; Park, Hyung Wook; Hwang, Gyo-Seung; Kim, Dae-Kyeong; Park, Young-Ah; Park, Hyoung-Seob; Cho, Yongkeun; Oh, Seil; Choi, Jong-Il; Kim, Young-Hoon | Korea Univ, Div Cardiol, Coll Med, 73 Goryeodae Ro, Seoul 02841, South Korea; Korea Univ, Med Ctr, 73 Goryeodae Ro, Seoul 02841, South Korea; Gachon Univ, Gil Med Ctr, Dept Internal Med, Coll Med, Incheon, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Internal Med, Coll Med, Daejeon, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul St Marys Hosp, Seoul, South Korea; Wonkwang Univ, Wonkwang Univ Hosp, Dept Internal Med, Sch Med, Iksan, South Korea; Yonsei Univ, Severance Cardiovasc Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Heart Vasc & Stroke Inst, Dept Internal Med,Sch Med, Seoul, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Cardiol, Sch Med, Gwangju, South Korea; Ajou Univ, Dept Cardiol, Sch Med, Suwon, South Korea; Inje Univ, Busan Paik Hosp, Dept Internal Med, Coll Med, Busan, South Korea; Keimyung Univ, Coll Med, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea | Oh, Suk-Kyu/JFJ-9359-2023; Kim, Ji/AAO-7560-2021; Jeong, JooHee/KHT-5684-2024; Choi, Jong-Il/P-7476-2018; Kim, SOOCHI/AAD-6959-2020; Pak, Hui-Nam/C-4266-2015; Kim, Tae/B-9921-2013; Oh, Seil/J-5539-2012; Kim, Young-Hoon/AAO-5792-2021 | 57547817300; 55642596100; 55661794500; 57216351516; 58106265100; 12759857000; 36663894100; 54393432200; 14021940000; 36079407700; 7101865848; 6508172107; 35275710300; 7202677645; 14631888200; 57221715952; 36175197800; 9249593500; 8552086700; 55722509800; 57328806500 | jongilchoi@korea.ac.kr; | KOREAN CIRCULATION JOURNAL | KOREAN CIRC J | 1738-5520 | 1738-5555 | 53 | 10 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2023 | 3 | 32.2 | 0.52 | 2025-06-25 | 2 | 3 | Genetic testing; High-throughput nucleotide sequencing; Channelopathies; Cardiomyopathies | SUDDEN CARDIAC DEATH; LONG QT SYNDROME; MEDICAL GENETICS; AMERICAN-COLLEGE; CARDIOMYOPATHY; STATEMENT | Cardiomyopathies; Channelopathies; Genetic testing; High-throughput nucleotide sequencing | genomic DNA; adolescent; adult; aged; arrhythmogenic right ventricular dysplasia; Article; bioinformatics; Brugada syndrome; catecholaminergic polymorphic ventricular tachycardia; clinical feature; cohort analysis; comorbidity; controlled study; echocardiography; family history; female; gene frequency; genetic screening; genetic trait; genetic variability; genotype; heart left ventricle ejection fraction; heart repolarization; heart ventricle fibrillation; heart ventricle tachycardia; high throughput sequencing; human; idiopathic disease; inherited arrhythmia syndrome; Korean (people); long QT syndrome; major clinical study; male; middle aged; missense mutation; multicenter study; onset age; sex ratio; short QT syndrome; sudden cardiac death; young adult | English | 2023 | 2023-10 | 10.4070/kcj.2023.0083 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Electrically conductive metal oxide-Assisted multifunctional separator for highly stable Lithium-Metal batteries | Lithium (Li) metal anodes have received intensive attention owing to its high specific capacity and low redox potential. However, chronic issues related to dendritic Li growth have hindered the pragmatic use of Li-metal batteries (LMBs). As one of feasible approaches, depositing a functional material on the separator is an efficient strategy for improving the electrochemical stability of LMBs. In this paper, we report a functionalized separator, comprising a nitrided niobium dioxide (named as n-NbO2) and a polypropylene (PP) separator. It is identified that niobium oxide interact with metallic Li, resulting in redistributing the localized Li ion. The nNbO2-coated separator with enhanced electrical conductivity promotes Li plating/stripping process, reinforcing the Li ion redistribution effect. Due to these properties, Li-Cu cells with the n-NbO2-coated separator show the most outstanding cycle stability with high Coulombic efficiency (CE) over 200 cycles. | Kim, Junghwan; Kwon, Kihwan; Roh, Kwangchul; Kwon, Jiseok; Song, Taeseup; Kim, Patrick Joohyun; Choi, Junghyun | Korea Inst Ceram Engn & Technol, Energy Storage Mat Ctr, Jinju 52851, South Korea; Kyungpook Natl Univ, Dept Appl Chem, Daegu 41566, South Korea; Hanyang Univ, Dept Energy Engn, Seoul 133791, South Korea | 55966669500; 58045803700; 35175060800; 57190337347; 25825726200; 57195611779; 59883103900 | pjkim@knu.ac.kr;jchoi@kicet.re.kr; | ELECTROCHEMISTRY COMMUNICATIONS | ELECTROCHEM COMMUN | 1388-2481 | 1873-1902 | 154 | SCIE | ELECTROCHEMISTRY | 2023 | 4.7 | 32.2 | 0.67 | 2025-06-25 | 7 | 7 | Li -metal batteries; Functionalized separator; Niobium oxide; Li ion redistribution; Enhanced electrical conductivity | ANODE; LAYER; COMPOSITE; NB2O5 | Enhanced electrical conductivity; Functionalized separator; Li ion redistribution; Li-metal batteries; Niobium oxide | Binary alloys; Copper alloys; Electric conductivity; Functional materials; Lithium-ion batteries; Niobium oxide; Polypropylenes; Redox reactions; Separators; Coated separator; Electrical conductivity; Enhanced electrical conductivity; Functionalized; Functionalized separator; Ion redistribution; Lithium ion redistribution; Lithium ions; Lithium metals; Lithium-metal battery; Ions | English | 2023 | 2023-09 | 10.1016/j.elecom.2023.107558 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Towards high performance Li metal batteries: Surface functionalized graphene separator with improved electrochemical kinetics and stability | Lithium (Li) metal is a promising anode for next-generation batteries owing to its ultrahigh theoretical capacity (3,860 mAh g-1) and the lowest reduction potential (-3.04 vs SHE at RT). However, the development of Li-metal batteries (LMBs) is still in the research stage due to the inherent problems related to the growth of Li dendrites and unlimited volume change in Li metal. Among diverse approaches, the introduction of functional separators is regarded as an effective strategy for improving the safety and electrochemical performance of LMBs. Herein, we deposited two different graphene layers onto the separators to explore the influence of surface functionalized graphene layer on the electrochemical performance and cycle stability of LMBs. When a surface functionalized graphene separator (SFGS) was used in the LMBs, it exhibited superior electrolyte wettability than a graphene separator (GS), contributing to the improved ionic conductivity and homogeneous Li-ion flux. Due to the improved electrochemical kinetics and reversible electrochemical reactions, Li/Cu cells with the SFGS exhibited the most stable cycle performance with a high Coulombic efficiency of 98 % over 200 cycles compared with other Li/Cu cells. Our strategy would resolve many issues related to the poor electrochemical reversibility of Li-metal anodes and advance the development of practical surface-modified separators for high-performance LMBs. | Kwon, Kihwan; Kim, Junghwan; Roh, Kwangchul; Kim, Patrick Joohyun; Choi, Junghyun | Korea Inst Ceram Engn & Technol, Energy Storage Mat Ctr, Jinju 52851, South Korea; Kyungpook Natl Univ, Dept Appl Chem, Daegu 41566, South Korea | 58045803700; 55966669500; 35175060800; 57195611779; 59883103900 | pjkim@knu.ac.kr;jchoi@kicet.re.kr; | ELECTROCHEMISTRY COMMUNICATIONS | ELECTROCHEM COMMUN | 1388-2481 | 1873-1902 | 157 | SCIE | ELECTROCHEMISTRY | 2023 | 4.7 | 32.2 | 1.25 | 2025-06-25 | 11 | 13 | Li-metal batteries; Functional separator; Graphene; Surface functionalization | POLYETHYLENE SEPARATORS; LITHIUM; ANODE | Functional separator; Graphene; Li-metal batteries; Surface functionalization | Anodes; Electrolytes; Lithium; Lithium-ion batteries; Separators; Electrochemical kinetics; Electrochemical performance; Functional separator; Functionalized graphene; Graphene layers; Li metal; Lithium metals; Lithium-metal battery; Performance; Surface Functionalization; Graphene | English | 2023 | 2023-12 | 10.1016/j.elecom.2023.107598 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | ATF6 is a critical regulator of cadmium-mediated apoptosis in spermatocytes | In this study, we examined the mechanisms of cadmium exposure-induced endoplasmic reticulum (ER) stress response and apoptosis in spermatocytes. Responses to cadmium toxicity were investigated using spermatocytes overexpressing p50ATF6, ATF4, and spliced XBP1s, belonging to the 3 unfolded protein response pathways. The ER stress and apoptosis response to cadmium were most strongly stimulated through the activating transcription factor 6 (ATF6) pathway; in contrast, siRNA-induced inhibition of protein expression could reduce apoptosis under stressful conditions. An in vivo experiment using mice confirmed that upregulation of p50ATF6 in the testis increased apoptosis in response to cadmium exposure. Further, when confirming the correlation between ER stress and MAPK in cadmium toxicity, p38 MAPK phosphorylation was strongly regulated by p50ATF6; p-p38 also mediated the activity of p50ATF6. Overall, these findings suggest that modulating the activity of p38 MAPK and p50ATF6 in cadmium exposure-induced toxicity can be considered a potential strategy to treat infertility. | Lee, Sung Woo; Kim, Bokyung; Seong, Jung Bae; Park, Young-Ho; Lee, Hong Jun; Lee, Dong-Seok | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Natl Primate Res Ctr, Cheongju 28116, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Futurist Anim Resource & Res Ctr FARRC, Cheongju 28116, South Korea; Chungbuk Natl Univ, Coll Med, Cheongju 28644, South Korea; Chungbuk Natl Univ, Med Res Inst, Cheongju 28644, South Korea; huMetaCELL Inc, Res Inst, Gyeonggi Do, Bucheon, South Korea | lee, wj/JNR-4926-2023; Lee, Seung Eun/ABG-1607-2021 | 57939888700; 57205869587; 57202134219; 56246852400; 35215736300; 57210068061 | lee1@knu.ac.kr; | TOXICOLOGICAL SCIENCES | TOXICOL SCI | 1096-6080 | 1096-0929 | 194 | 2 | SCIE | TOXICOLOGY | 2023 | 3.4 | 32.5 | 0.97 | 2025-06-25 | 7 | 6 | cadmium; endoplasmic reticulum (ER) stress; ATF6; apoptosis; spermatocyte | ENDOPLASMIC-RETICULUM STRESS; MOLECULAR CHAPERONE; ADP-RIBOSYLATION; CELL-DEATH; SPERMATOGENESIS; ROLES; GRP78 | apoptosis; ATF6; cadmium; endoplasmic reticulum (ER) stress; spermatocyte | Activating Transcription Factor 6; Animals; Apoptosis; Cadmium; Endoplasmic Reticulum Stress; Male; Mice; p38 Mitogen-Activated Protein Kinases; Spermatocytes; activating transcription factor 4; activating transcription factor 6; cadmium; calcium; mitogen activated protein kinase 14; reactive oxygen metabolite; small interfering RNA; X box binding protein 1; activating transcription factor 6; mitogen activated protein kinase p38; adult; animal cell; animal experiment; animal model; apoptosis; Article; cadmium poisoning; calcium cell level; cell stimulation; cell survival; cell viability; controlled study; down regulation; endoplasmic reticulum stress; enzyme activity; gene overexpression; in vivo study; intracellular space; male; mouse; nonhuman; protein expression; protein phosphorylation; spermatocyte; testis; unfolded protein response; upregulation; animal; apoptosis; endoplasmic reticulum stress; metabolism; physiology; spermatocyte | English | 2023 | 2023-07-28 | 10.1093/toxsci/kfad055 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Mineral bone disorder in children with chronic kidney disease: Data from the KNOW-Ped CKD (Korean cohort study for outcome in patients with pediatric chronic kidney disease) study | BackgroundChildren with chronic kidney disease (CKD) are at high risk of mineral bone disorder (MBD), which leads to fractures, growth retardation, and cardiovascular disease. We aimed to comprehensively understand the relationship between renal function and factors related to MBD and evaluate the prevalence and distribution characteristics of MBD, specifically among Korean patients from the KNOW-PedCKD cohort.MethodsFrom the baseline data of the KNOW-PedCKD cohort, we examined the prevalence and distribution of MBD in 431 Korean pediatric CKD patients, including the level of corrected total calcium, serum phosphate, serum alkaline phosphatase, serum intact parathyroid hormone (iPTH), fibroblast growth factor 23 (FGF-23), serum vitamin D, fractional excretion of phosphate (FEP), and bone densitometry Z-scores.ResultsThe median serum calcium level remained relatively normal regardless of the CKD stage. The levels of 1,25-dihydroxy vitamin D, urine calcium-to-creatinine ratio, and bone densitometry Z-score significantly decreased with advancing CKD stage, while those of serum phosphate, FGF-23, and FEP significantly increased with CKD stage. The prevalence of hyperphosphatemia (17.4%, 23.7%, and 41.2% from CKD stages 3b, 4, and 5, respectively) and hyperparathyroidism (37.3%, 57.4%, 55.3%, and 52.9% from CKD stages 3a, 3b, 4, and 5, respectively) significantly increased with the CKD stage. Prescriptions of medications, such as calcium supplements (39.1%, 42.1%, 82.4%), phosphate binders (39.1%, 43.4%, 82.4%), and active vitamin D (21.7%, 44.7%, and 64.7%) significantly increased with CKD stage 3b, 4, and 5, respectively.ConclusionsThe results demonstrated the prevalence and relationship of abnormal mineral metabolism and bone growth according to CKD stage in Korean pediatric CKD patients for the first time. | Jung, Jiwon; Lee, Keum Hwa; Park, Eujin; Park, Young Seo; Kang, Hee Gyung; Ahn, Yo Han; Ha, Il-Soo; Kim, Seong Heon; Cho, Heeyeon; Han, Kyoung Hee; Cho, Min Hyun; Choi, Hyun Jin; Lee, Joo Hoon; Shin, Jae Il | Ulsan Univ, Asan Med Ctr Childrens Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Univ Yonsei, Severance Childrens Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Hallym Univ, Kangnam Sacred Heart Hosp, Dept Pediat, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Childrens Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pediat, Seoul, South Korea; Jeju Natl Univ, Sch Med, Dept Pediat, Jeju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Natl Inst Food & Drug Safety Evaluat, Minist Food & Drug Safety, Cheongju, South Korea; Yonsei Univ, Inst Kidney Dis Res, Coll Med, Seoul, South Korea | ; SHIN, JAE IL/J-6922-2017; Lee, Seok/ABF-7548-2020; Kim, SOOCHI/AAD-6959-2020; Jung, JiWon/AAF-6236-2020 | 56518750800; 57193231590; 56194662500; 56701214400; 7404071546; 57219957477; 57226423279; 57213778393; 15724272900; 58389645900; 7401727726; 55776937072; 37112404100; 57964880100 | pedkid@gmail.com;shinji@yuhs.ac; | FRONTIERS IN PEDIATRICS | FRONT PEDIATR | 2296-2360 | 11 | SCIE | PEDIATRICS | 2023 | 2.1 | 32.5 | 0.98 | 2025-06-25 | 4 | 3 | mineral bone disorder; children; hyperphosphatemia; hyperparathyroidism; chronic kidney disease; bone densitometry | GROWTH-FACTOR 23; RENAL OSTEODYSTROPHY; PHOSPHATE BINDERS; VITAMIN-D; FGF-23; FGF23; SERUM; PROGRESSION; PREVALENCE; PHOSPHORUS | bone densitometry; children; chronic kidney disease; hyperparathyroidism; hyperphosphatemia; mineral bone disorder | alkaline phosphatase; calcitriol; calcium; fibroblast growth factor 23; mineral; parathyroid hormone; phosphate; phosphate binding agent; vitamin D; adult; alkaline phosphatase blood level; analytical parameters; Article; bone age; bone densitometry; bone disease; calcium blood level; chronic kidney failure; clinical outcome; cohort analysis; dietary supplement; enzyme linked immunosorbent assay; excretion fraction; human; hypercalcemia; hyperparathyroidism; hyperphosphatemia; hypocalcemia; Korea; major clinical study; mineral bone disorder; mineral metabolism; parathyroid hormone blood level; phosphate blood level; prevalence; urine calcium to creatinine ratio; vitamin blood level | English | 2023 | 2023-02-17 | 10.3389/fped.2023.994979 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | Mineral bone disorder in children with chronic kidney disease: data from the KNOW-Ped CKD (Korean cohort study for outcome in patients with pediatric chronic kidney disease) study (vol 11, 994979, 2023) | Jung, Jiwon; Lee, Keum Hwa; Park, Eujin; Park, Young Seo; Kang, Hee Gyung; Ahn, Yo Han; Ha, Il-Soo; Kim, Seong Heon; Cho, Heeyeon; Han, Kyoung Hee; Cho, Min Hyun; Choi, Hyun Jin; Lee, Joo Hoon; Shin, Jae Il | Ulsan Univ, Asan Med Ctr Childrens Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Univ Yonsei, Severance Childrens Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Hallym Univ, Dept Pediat, Kangnam Sacred Heart Hosp, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Childrens Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pediat, Seoul, South Korea; Jeju Natl Univ, Sch Med, Dept Pediat, Jeju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Minist Food & Drug Safety, Natl Inst Food & Drug Safety Evaluat, Cheongju, South Korea; Yonsei Univ, Inst Kidney Dis Res, Coll Med, Seoul, South Korea | SHIN, JAE IL/J-6922-2017; Kim, SOOCHI/AAD-6959-2020; Lee, Seok/ABF-7548-2020 | 56518750800; 57193231590; 56194662500; 56701214400; 7404071546; 57219957477; 57226423279; 57213778393; 15724272900; 58389645900; 7401727726; 55776937072; 37112404100; 57964880100 | pedkid@gmail.com;shinji@yuhs.ac; | FRONTIERS IN PEDIATRICS | FRONT PEDIATR | 2296-2360 | 11 | SCIE | PEDIATRICS | 2023 | 2.1 | 32.5 | 0 | 2025-06-25 | 0 | 0 | mineral bone disorder; hyperphosphatemia; hyperparathyroidism; chronic kidney disease; bone densitometry | bone densitometry; chronic kidney disease; hyperparathyroidism; hyperphosphatemia; mineral bone disorder | mineral; article; bone densitometry; bone disease; child; chronic kidney failure; cohort analysis; disease control; drug therapy; female; human; hyperparathyroidism; hyperphosphatemia; Korea; major clinical study; male; peer review; prevention; therapy | English | 2023 | 2023-06-14 | 10.3389/fped.2023.1221302 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Modeling geogrid-stabilized aggregate base courses considering local stiffness enhancement | Lateral restraint is the primary stabilization mechanism associated with the interlocking of aggregate particles in the geogrid apertures. This paper presents findings from a laboratory study which quantifies the local stiffness enhancement of aggregates through micromechanical interlocking provided by two different types of geogrids. These findings are applied to model the resilient response characteristics of geogrid-stabilized base course composite systems. Using three pairs of bender elements as shear wave transducers, horizontal stiffness profiles were determined above mid-heights of aggregate specimens. For two types of geogrids with square- and triangular-shaped apertures, the shear modulus profiles decreased moving away from the geogrid location. Based on a relationship for aggregates, resilient modulus was estimated from the shear modulus. Considering the variations in resilient moduli with distance from the geogrid location, the local stiffness enhancements provided by the two geogrid types were assigned to modulus profiles of a geogrid-stabilized aggregate base course in flexible pavement mechanistic analysis and modeling. The modeling results demonstrate the effect of geogrid base stabilization on the computed pavement resilient responses for both geogrid types. The sublayering approach which properly considers modeling of the geogrid influence zone could be effectively used in mechanistic analysis of a geogrid-stabilized pavement system. | Byun, Y-H.; Qamhia, I. I. A.; Kang, M.; Tutumluer, E.; Wayne, M. H. | Kyungpook Natl Univ, Sch Agr Civil & Bioind Engn, Daegu, South Korea; Univ Illinois, Dept Civil & Environm Engn, Urbana, IL USA; Univ St Thomas, Dept Civil Engn, St Paul, MN USA; Univ Illinois, Dept Civil & Environm Engn, Urbana, IL USA; Tensar Int Corp, Applicat Technol & Engn, Alpharetta, GA USA | Kang, Mingu/AAS-7778-2021; Byun, Yong-Hoon/JKI-8441-2023; Tutumluer, Erol/O-2650-2019 | 42761048000; 55586474700; 57935128000; 6603812780; 7006129933 | yhbyun@knu.ac.kr;qamhia2@illinois.edu;kang4575@stthomas.edu;tutumlue@illinois.edu;mark.wayne@cmc.com; | GEOSYNTHETICS INTERNATIONAL | GEOSYNTH INT | 1072-6349 | 1751-7613 | 31 | 6 | SCIE | ENGINEERING, GEOLOGICAL;GEOSCIENCES, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2023 | 2.8 | 32.5 | 0.68 | 2025-06-25 | 4 | 5 | Geosynthetics; Aggregates; Base course; Geogrid; Layered elastic analysis; Shear wave | BENDER ELEMENT; PERFORMANCE; BEHAVIOR; STRAIN; SAND | Aggregates; Base course; Geogrid; Geosynthetics; Layered elastic analysis; Shear wave | Elastic moduli; Geosynthetic materials; Pavements; Shear flow; Shear strain; Shear waves; Stabilization; Stiffness; Aggregate base; Base course; Elastic analysis; Geogrids; Geosynthetics; Interlockings; Layered elastic analyse; Mechanistic analysis; Resilient modulus; Stiffness enhancement; aggregate; base course; elasticity; geogrid; numerical model; S-wave; stiffness; Aggregates | English | 2023 | 2023-08-31 | 10.1680/jgein.23.00086 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Anticancer effects of gossypetin from Hibiscus sabdariffa in oral squamous cell carcinoma | Objective: Gossypetin, isolated from Hibiscus sabdariffa L, has been shown to have various pharmacological effects including anti-inflammatory and antibacterial activity against various diseases. However, since the effect of gossypetin in oral cancer remains to be reported, we aimed to investigate the anticancer activity and mechanisms of gossypetin in oral squamous cell carcinoma (OSCC). Methodology: The proliferation of OSCC cells was evaluated by cell viability and soft agar colony assays. The effects of gossypetin on the migration and invasion of OSCC cells was investigated by wound healing and transwell invasion assays, respectively. Apoptosis and cell cycle arrest were measured by flow cytometry. Moreover, the anticancer mechanism of gossypetin in OSCC cells was analyzed by western blotting. Results: Gossypetin inhibited the proliferation, migration, and invasion of OSCC cells and induced apoptosis by upregulating the Bax/Bcl-2 ratio and cell cycle arrest at the G2/M phase. Furthermore, gossypetin regulated the activation of extracellular signal-regulated kinase and nuclear factor-kappa B. Conclusion: Results showed that gossypetin inhibits the proliferation, migration, and invasion of OSCC cells and triggers apoptosis and cell cycle arrest in OSCC. Therefore, gossypetin has the potential for use as a chemopreventive agent in oral cancer. | Huang, Ke; Liu, Zhibin; Kim, Myoung-Ok; Kim, Ki-Rim | Kyungpook Natl Univ, Coll Sci & Technol, Dept Dent Hyg, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Ctr Horse Ind, Dept Anim Sci & Biotechnol, 2559 Gyeongsang Daero, Sangju 37224, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Dept Text Engn, 2559 Gyeongsang Daero, Sangju 37224, Gyeongsangbuk D, South Korea | ; Liu, Zhibin/AAL-6838-2021 | 58639636600; 58640210100; 8934745900; 35793746200 | ok4325@knu.ac.kr;rim0804@knu.ac.kr; | JOURNAL OF APPLIED ORAL SCIENCE | J APPL ORAL SCI | 1678-7757 | 1678-7765 | 31 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2023 | 2.2 | 32.6 | 0.97 | 2025-06-25 | 3 | 4 | Apoptosis; Gossypetin; Oral squamous cell carcinoma; Proliferation | CANCER; APOPTOSIS; INDUCTION; INVASION; OUTCOMES; CAVITY | Apoptosis; Gossypetin; Oral squamous cell carcinoma; Proliferation | Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Head and Neck Neoplasms; Hibiscus; Humans; Mouth Neoplasms; Squamous Cell Carcinoma of Head and Neck; gossypetin; apoptosis; cell motion; cell proliferation; head and neck squamous cell carcinoma; head and neck tumor; Hibiscus; human; mouth tumor; pathology; squamous cell carcinoma; tumor cell line | English | 2023 | 2023 | 10.1590/1678-7757-2023-0243 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Butyrate producers, "The Sentinel of Gut": Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics | Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological importance than the other major SCFAs (acetate and propionate). Most butyrate producers belong to the Clostridium cluster of the phylum Firmicutes, such as Faecalibacterium, Roseburia, Eubacterium, Anaerostipes, Coprococcus, Subdoligranulum, and Anaerobutyricum. They metabolize carbohydrates via the butyryl-CoA: acetate CoA-transferase pathway and butyrate kinase terminal enzymes to produce most of butyrate. Although, in minor fractions, amino acids can also be utilized to generate butyrate via glutamate and lysine pathways. Butyrogenic microbes play a vital role in various gut-associated metabolisms. Butyrate is used by colonocytes to generate energy, stabilizes hypoxia-inducible factor to maintain the anaerobic environment in the gut, maintains gut barrier integrity by regulating Claudin-1 and synaptopodin expression, limits pro-inflammatory cytokines (IL-6, IL-12), and inhibits oncogenic pathways (Akt/ERK, Wnt, and TGF-beta signaling). Colonic butyrate producers shape the gut microbial community by secreting various anti-microbial substances, such as cathelicidins, reuterin, and beta-defensin-1, and maintain gut homeostasis by releasing anti-inflammatory molecules, such as IgA, vitamin B, and microbial anti-inflammatory molecules. Additionally, butyrate producers, such as Roseburia, produce anti-carcinogenic metabolites, such as shikimic acid and a precursor of conjugated linoleic acid. In this review, we summarized the significance of butyrate, critically examined the role and relevance of butyrate producers, and contextualized their importance as microbial therapeutics. | Singh, Vineet; Lee, GyuDae; Son, HyunWoo; Koh, Hong; Kim, Eun Soo; Unno, Tatsuya; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Yonsei Univ Coll Med, Severance Hosp, Severance Fecal Microbiota Transplantat Ctr, Dept Pediat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Jeju Natl Univ, Fac Biotechnol, Sch Life Sci, SARI, Jeju, South Korea; Kyungpook Natl Univ, Dept Integrat Biotechnol, Daegu, South Korea | Unno, Tatsuya/C-1522-2012; Singh, Vineet/ABC-7000-2021; Kim, Sang/J-5398-2012; shin, Jaeho/K-6792-2013 | 57211642447; 57222101785; 57218872919; 35789948700; 57203086704; 22941915600; 57224125922 | tatsu@jejunu.ac.kr;jhshin@knu.ac.kr; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 13 | SCIE | MICROBIOLOGY | 2023 | 4 | 32.6 | 15.41 | 2025-06-25 | 270 | 274 | butyrate producers; microbial homeostasis; gut epithelial barrier; immunomodulation; gut inflammation; colorectal cancer; gut-organ axis | FAECALIBACTERIUM-PRAUSNITZII; ANAEROSTIPES-HADRUS; COLORECTAL-CANCER; HUMAN FECES; IN-VITRO; BACTERIA; DEGRADATION; FERMENTATION; METABOLISM; PROPIONATE | butyrate producers; colorectal cancer; gut epithelial barrier; gut inflammation; gut-organ axis; immunomodulation; microbial homeostasis | acetate coenzyme a; acetate coenzyme A ligase; acetic acid; beta defensin 1; butyric acid; butyryl coenzyme a; cathelicidin; claudin 1; G protein coupled receptor; glutamic acid; hemagglutinin; hypoxia inducible factor; interleukin 12; interleukin 6; linoleic acid; lysine; oligosaccharide; polyphenol; polysaccharide; prebiotic agent; propionic acid; reuterin; synaptopodin; unclassified drug; Aanaerobutyricum; Actinobacteria; anaerostipe; antimicrobial therapy; Bacteroidetes; carcinogenesis; colon cell; colorectal cancer; Coprococcus; enteritis; Eubacterium; Faecalibacterium; Firmicutes; Fusobacteria; homeostasis; human; immunomodulation; intestine epithelium cell; irritable colon; Lachnospiraceae; lifestyle; microbial community; nonhuman; physiological adaptation; prospective study; Review; Roseburia; subdoligranulum; TGF beta signaling; tight junction; TNF signaling | English | 2023 | 2023-01-12 | 10.3389/fmicb.2022.1103836 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Editorial Material | Editorial: Gene regulation of fungal secondary metabolism | Wang, Pinmei; Park, Hee-Soo; Wang, Wenjie; Yin, Wen-Bing | Zhejiang Univ, Ocean Coll, Zhoushan, Peoples R China; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, Hangzhou, Peoples R China; Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing, Peoples R China | Yin, Wen-Bing/AAF-4825-2021; Wang, Wenjie/HIR-8486-2022; Park, Hee-Soo/AAC-6422-2019 | 36174480700; 15751448400; 57188876521; 18134738200 | wangpinmei@zju.edu.cn;yinwb@im.ac.cn; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 14 | SCIE | MICROBIOLOGY | 2023 | 4 | 32.6 | 0.54 | 2025-06-25 | 0 | 1 | gene regulation; transcription factors; fungal secondary metabolism; biosynthesis; secondary metabolites | biosynthesis; fungal secondary metabolism; gene regulation; secondary metabolites; transcription factors | abscisic acid; aflatoxin; F box protein; flavonoid; fumonisin B1; jasmonic acid methyl ester; methyltransferase; mevinolin; mycotoxin; patulin; penicillin derivative; photosensitizing agent; transcription factor; triterpenoid; Aspergillus; Basidiomycetes; biosynthesis; Botrytis cinerea; Editorial; endophytic fungus; fungal biomass; fungal metabolism; Fusarium; Fusarium proliferatum; Ganoderma lucidum; gene; gene control; gene expression; Ginkgo biloba; Glmhr1 gene; laeA gene; liquid chromatography-mass spectrometry; mycelium; nonhuman; Saccharomyces cerevisiae; Schizosaccharomyces pombe; secondary metabolism; transcription regulation | English | 2023 | 2023-08-15 | 10.3389/fmicb.2023.1260849 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Genome insight and probiotic potential of three novel species of the genus Corynebacterium | Three bacterial strains, B5-R-101(T), TA-R-1(T), and BL-R-1(T), were isolated from the feces of a healthy Korean individual. Cells of these strains were Gram-stain-positive, facultatively anaerobic, oxidase-negative, catalase-positive, rod-shaped, and non-motile. They were able to grow within a temperature range of 10-42 & DEG;C (optimum, 32-37 & DEG;C), at a pH range of 2.0-10.0 (optimum, pH 5.5-8.0), and at NaCl concentration of 0.5-10.5% (w/v). All the three strains exhibited 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities ranging from 58 & PLUSMN; 1.62 to 79 & PLUSMN; 1.46% (% inhibition). These strains survived in lower pH (2.0) and in 0.3% bile salt concentration for 4 h. They did not show hemolytic activity and exhibited antimicrobial activity against pathogenic bacteria, such as Escherichia coli, Acinetobacter baumannii, Staphylococcus aureus, and Salmonella enterica. The genomic analysis presented no significant concerns regarding antibiotic resistance or virulence gene content, indicating these strains could be potential probiotic candidates. Phylogenetic analysis showed that they belonged to the genus Corynebacterium, with 98.5-99.0% 16S rRNA gene sequence similarities to other members of the genus. Their major polar lipids were diphosphatidylglycerol and phosphatidylglycerol. The abundant cellular fatty acids were C-16:0, C-18:1 & omega;9c, and anteiso-C-19:0. Genomic analysis of these isolates revealed the presence of genes necessary for their survival and growth in the gut environment, such as multi-subunit ATPases, stress response genes, extracellular polymeric substance biosynthesis genes, and antibacterial genes. Furthermore, the genome of each strain possessed biosynthetic gene clusters with antioxidant and antimicrobial potentials, including terpenes, saccharides, polyketides, post-translationally modified peptides (RIPPs), and non-ribosomal peptides (NRPs). In silico DNA-DNA hybridization (dDDH) and average nucleotide identity (ANI) values were lower than the thresholds to distinguish novel species. Based on phenotypic, genomic, phylogenomic, and phylogenetic analysis, these potential probiotic strains represent novel species within the genus Corynebacterium, for which the names Corynebacterium intestinale sp. nov. (type strain B5-R-101(T) = CGMCC 1.19408(T) = KCTC 49761(T)), Corynebacterium stercoris sp. nov. (type strain TA-R-1(T) = CGMCC 1.60014(T) = KCTC 49742(T)), and Corynebacterium faecium sp. nov. (type strain BL-R-1(T) = KCTC 49735(T) = TBRC 17331(T)) are proposed. | Shamsuzzaman, Md; Dahal, Ram Hari; Kim, Shukho; Kim, Jungmin | Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea | ; Dahal, Ram Hari/H-8673-2016 | 58493605500; 57110097800; 24341187900; 57211297681 | minkim@knu.ac.kr; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 14 | SCIE | MICROBIOLOGY | 2023 | 4 | 32.6 | 1.96 | 2025-06-25 | 14 | 12 | Corynebacterium intestinale sp; nov; Corynebacterium stercoris sp; Corynebacterium faecium sp; probiotic; antimicrobial agent; antioxidant activities | LACTOBACILLUS; RESISTANCE; ALGORITHM; SEQUENCES; DATABASE; GENES | antimicrobial agent; antioxidant activities; Corynebacterium faeciumsp. nov; Corynebacterium intestinalesp. nov; Corynebacterium stercorissp. nov; probiotic | amikacin; ampicillin; antiinfective agent; aztreonam; carbohydrate; cardiolipin; cefotaxime; cefoxitin; ceftazidime; ciprofloxacin; colistin; erythromycin; gentamicin; oxacillin; phosphatidylglycerol; polyketide; RNA 16S; terpene; Acinetobacter baumannii; antibiotic sensitivity; antimicrobial activity; Article; colony forming unit; Corynebacterium; corynebacterium faecium; corynebacterium intestinale; corynebacterium stercoris; DNA DNA hybridization; DPPH radical scavenging assay; Escherichia coli; genome analysis; hemolysis; nonhuman; oxidative stress; pH; phenotype; phylogeny; Salmonella enterica; salt tolerance; Staphylococcus aureus; thin layer chromatography; virulence; whole genome sequencing | English | 2023 | 2023-07-06 | 10.3389/fmicb.2023.1225282 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Insight into gut dysbiosis of patients with inflammatory bowel disease and ischemic colitis | The collection of whole microbial communities (bacteria, archaea, fungi, and viruses) together constitutes the gut microbiome. Diet, age, stress, host genetics, and diseases cause increases or decreases in the relative abundance and diversity of bacterial species (dysbiosis). We aimed to investigate the gut microbial composition at different taxonomic levels of healthy controls (HCs) with active Crohn's disease (CD), ulcerative colitis (UC), and ischemic colitis (IC) using culture- and non-culture-based approaches and identify biomarkers to discriminate CD, UC, or IC. We determined the specific changes in the gut microbial profile using culture-independent (16S rRNA gene amplicon sequencing) as well as culture-based (culturomic) approaches. Biomarkers were validated using quantitative Real-Time PCR (qPCR). In both methods, bacterial diversity and species richness decreased in disease-associated conditions compared with that in HCs. Highly reduced abundance of Faecalibacterium prausnitzii and Prevotella sp. and an increased abundance of potentially pathogenic bacteria such as Enterococcus faecium, Enterococcus faecalis, and Escherichia coli in all CD, UC, or IC conditions were observed. We noted a high abundance of Latilactobacillus sakei in CD patients; Ligilactobacillus ruminis in UC patients; and Enterococcus faecium, Escherichia coli, and Enterococcus faecalis in IC patients. Highly reduced abundance of Faecalibacterium prausnitzii in all cases, and increased abundance of Latilactobacillus sakei and Enterococcus faecium in CD, Ligilactobacillus ruminis and Enterococcus faecium in UC, and Enterococcus faecium, Escherichia coli, and Enterococcus faecalis in IC could be biomarkers for CD, UC, and IC, respectively. These biomarkers may help in IBD (CD or UC) and IC diagnosis. | Dahal, Ram Hari; Kim, Shukho; Kim, Yu Kyung; Kim, Eun Soo; Kim, Jungmin | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Kim, Wonhee/AAA-1074-2021; Dahal, Ram Hari/H-8673-2016; Kim, Sang/J-5398-2012 | 57110097800; 24341187900; 9237571900; 57203086704; 57211297681 | minkim@knu.ac.kr; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 14 | SCIE | MICROBIOLOGY | 2023 | 4 | 32.6 | 5.38 | 2025-06-25 | 34 | 34 | gut microbiome; inflammatory bowel disease; ischemic colitis; gut dysbiosis; biomarker; culturomics; uncultured gut bacteria; probiotics | MICROBIOTA | biomarker; culturomics; gut dysbiosis; gut microbiome; inflammatory bowel disease; ischemic colitis; probiotics; uncultured gut bacteria | biological marker; Alphaproteobacteria; Article; bacterial gene; bacterium isolation; Bacteroides fragilis; Bacteroidetes; Betaproteobacteria; Bifidobacteriaceae; bioinformatics; controlled study; Crohn disease; dysbiosis; Enterococcus faecalis; Enterococcus faecium; Escherichia coli; Faecalibacterium; Faecalibacterium prausnitzii; Gammaproteobacteria; inflammatory bowel disease; ischemic colitis; Lactobacillus paracasei; Lactobacillus sakei; Ligilactobacillus; metagenomics; microbial community; microbial diversity; nonhuman; real time polymerase chain reaction; upregulation | English | 2023 | 2023-05-11 | 10.3389/fmicb.2023.1174832 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Microbial communities in aerosol generated from cyanobacterial bloom-affected freshwater bodies: an exploratory study in Nakdong River, South Korea | Toxic blooms of cyanobacteria, which can produce cyanotoxins, are prevalent in freshwater, especially in South Korea. Exposure to cyanotoxins via ingestion, inhalation, and dermal contact may cause severe diseases. Particularly, toxic cyanobacteria and their cyanotoxins can be aerosolized by a bubble-bursting process associated with a wind-driven wave mechanism. A fundamental question remains regarding the aerosolization of toxic cyanobacteria and cyanotoxins emitted from freshwater bodies during bloom seasons. To evaluate the potential health risk of the aerosolization of toxic cyanobacteria and cyanotoxins, the objectives of this study were as follows: 1) to quantify levels of microcystin in the water and air samples, and 2) to monitor microbial communities, including toxic cyanobacteria in the water and air samples. Water samples were collected from five sites in the Nakdong River, South Korea, from August to September 2022. Air samples were collected using an air pump with a mixed cellulose ester membrane filter. Concentrations of total microcystins were measured using enzyme-linked immunosorbent assay. Shotgun metagenomic sequencing was used to investigate microbial communities, including toxic cyanobacteria. Mean concentrations of microcystins were 960 & mu;g/L ranging from 0.73 to 5,337 & mu;g/L in the water samples and 2.48 ng/m(3) ranging from 0.1 to 6.8 ng/m(3) in the air samples. In addition, in both the water and air samples, predominant bacteria were Microcystis (PCC7914), which has a microcystin-producing gene, and Cyanobium. Particularly, abundance of Microcystis (PCC7914) comprised more than 1.5% of all bacteria in the air samples. This study demonstrates microbial communities with genes related with microcystin synthesis, antibiotic resistance gene, and virulence factors in aerosols generated from cyanobacterial bloom-affected freshwater body. In summary, aerosolization of toxic cyanobacteria and cyanotoxins is a critical concern as an emerging exposure route for potential risk to environmental and human health. | Kim, Jinnam; Lee, GyuDae; Han, Soyeong; Kim, Min-Ji; Shin, Jae-Ho; Lee, Seungjun | Pukyong Natl Univ, Coll Fisheries Sci, Div Food Sci, Major Food Sci & Nutr, Busan, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Kyungpook Natl Univ, NGS Core Facil, Daegu, South Korea | Kim, Min-Ji/Z-5205-2019; shin, Jaeho/K-6792-2013; Lee, Seungjun/S-9826-2019 | 56925829600; 57222101785; 58510007000; 57127351600; 57224125922; 56437333700 | jhshin@knu.ac.kr;paul5280@pknu.ac.kr; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 14 | SCIE | MICROBIOLOGY | 2023 | 4 | 32.6 | 0.98 | 2025-06-25 | 4 | 6 | harmful algal blooms; microcystin; Microcystis; aerosol; Nakdong River; metagenomics; microbiome | ANTIBIOTIC-RESISTANCE; MICROCYSTIN-LR; AIRBORNE ALGAE; EUTROPHICATION; MICROALGAE; RESISTOME; TOXICITY; SEQUENCE; IMPACTS; PROTEIN | aerosol; harmful algal blooms; metagenomics; microbiome; microcystin; Microcystis; Nakdong River | cyanobacterium toxin; fresh water; microcystin; virulence factor; Aeromonas; aerosol; algal bloom; antibiotic resistance; Article; Aspergillus; biochemical oxygen demand; Burkholderia; cyanobacterium; DNA extraction; environmental factor; enzyme linked immunosorbent assay; exploratory research; Flavobacterium; Fusarium; gene cluster; health hazard; Klebsiella; metagenomics; microbial community; microbial diversity; microbiome; Microcystis; Microcystis aeruginosa; nonhuman; phytoplankton; Planktothrix; quality control; river; Synechococcus; synthesis; water quality | English | 2023 | 2023-07-13 | 10.3389/fmicb.2023.1203317 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Red ginseng dietary fiber promotes probiotic properties of Lactiplantibacillus plantarum and alters bacterial metabolism | Korean red ginseng has been widely used as an herbal medicine. Red ginseng dietary fiber (RGDF) is a residue of the processed ginseng product but still contains bioactive constituents that can be applied as prebiotics. In this study, we evaluated changes on fermentation profiles and probiotic properties of strains that belong to family Lactobacillaceae with RGDF supplementation. Metabolomic analyses were performed to understand specific mechanisms on the metabolic alteration by RGDF and to discover novel bioactive compounds secreted by the RGDF-supplemented probiotic strain. RGDF supplementation promoted short-chain fatty acid (SCFA) production, carbon source utilization, and gut epithelial adhesion of Lactiplantibacillus plantarum and inhibited attachment of enteropathogens. Intracellular and extracellular metabolome analyses revealed that RGDF induced metabolic alteration, especially associated with central carbon metabolism, and produced RGDF-specific metabolites secreted by L. plantarum, respectively. Specifically, L. plantarum showed decreases in intracellular metabolites of oleic acid, nicotinic acid, uracil, and glyceric acid, while extracellular secretion of several metabolites including oleic acid, 2-hydroxybutanoic acid, hexanol, and butyl acetate increased. RGDF supplementation had distinct effects on L. plantarum metabolism compared with fructooligosaccharide supplementation. These findings present potential applications of RGDF as prebiotics and bioactive compounds produced by RGDF-supplemented L. plantarum as novel postbiotic metabolites for human disease prevention and treatment. | Jeon, Hyeon Ji; You, Seung-Hwan; Nam, Eoun Ho; Truong, Van-Long; Bang, Ji-Hong; Bae, Yeon-Ji; Rarison, Razanamanana H. G.; Kim, Sang-Kyu; Jeong, Woo-Sik; Jung, Young Hoon; Shin, Minhye | Kyungpook Natl Univ, Food & Bioind Res Inst, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu, South Korea; Korea Ginseng Corp, Lab Efficacy Res, Daejeon, South Korea; Inha Univ, Coll Med, Dept Microbiol, Incheon, South Korea; Inha Univ, Dept Biomed Sci, Program Biomed Sci & Engn, Incheon, South Korea | Jung, Young/F-1703-2013; Jeong, Woo-Sik/AAN-6885-2020; Jeon, Hyeon Ji/HPH-4892-2023 | 57795638700; 58091747400; 58035371200; 55925363400; 58150149300; 58150149400; 57930282700; 57748019200; 10440750200; 55550063700; 57208401604 | younghoonjung@knu.ac.kr;mhshin@inha.ac.kr; | FRONTIERS IN MICROBIOLOGY | FRONT MICROBIOL | 1664-302X | 14 | SCIE | MICROBIOLOGY | 2023 | 4 | 32.6 | 0.49 | 2025-06-25 | 3 | 3 | red ginseng; dietary fiber; probiotics; prebiotics; metabolomics | LACTOBACILLUS; MICROBIOTA; ALCOHOL; HEALTH | dietary fiber; metabolomics; prebiotics; probiotics; red ginseng | prebiotic agent; probiotic agent; short chain fatty acid; Article; bacterial growth; bacterial metabolism; bacterial strain; bacterium; carbon source; dietary fiber; enteropathogen; epithelium cell; ginseng; high performance liquid chromatography; Lactiplantibacillus plantarum; Lactobacillaceae; Lactobacillus reuteri; mass fragmentography; metabolome; metabolomics; nonhuman | English | 2023 | 2023-03-06 | 10.3389/fmicb.2023.1139386 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Ricci solitons on general relativistic spacetimes | The main aim of this manuscript is to characterize the general relativistic spacetimes with Ricci and gradient Ricci solitons. It is proven that if the metric of a general relativistic spacetime (M (4), xi) admitting a special unit timelike vector field xi is an almost Ricci soliton (g, xi, lambda), then (M (4), xi) is a perfect fluid spacetime, and almost Ricci soliton (g, xi, lambda) on (M (4), xi) becomes shrinking Ricci soliton. We prove that a general relativistic perfect fluid spacetime equipped with a special unit timelike vector field together with a Ricci soliton is an Einstein spacetime. In this sequel, we also prove that the Ricci soliton is shrinking, soliton vector field is Killing and the scalar curvature of the perfect fluid spacetime is constant. It is proven that a general relativistic perfect fluid spacetime together with a Ricci soliton is a generalized Robertson-Walker (GRW) spacetime. The existence of gradient Ricci solitons on general relativistic spacetimes are established. We also construct a non-trivial example of general relativistic spacetime equipped with a special unit timelike vector field, and verify some of our theorems. | Suh, Young Jin; Chaubey, Sudhakar Kumar | Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, RIRCM, Daegu 41566, South Korea; Univ Technol & Appl Sci, Dept Informat Technol, Sect Math, POB 77, Shinas 324, Oman | Chaubey, S./ABB-6952-2021 | 7202260479; 36117508600 | yjsuh@knu.ac.kr;sk22_math@yahoo.co.in; | PHYSICA SCRIPTA | PHYS SCRIPTA | 0031-8949 | 1402-4896 | 98 | 6 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2023 | 2.6 | 32.6 | 1.99 | 2025-06-25 | 9 | 12 | general relativistic spacetimes; perfect fluid spacetime; Ricci solitons; einstein spacetimes; killing vector field | ROBERTSON-WALKER SPACETIMES; CURVATURE; MANIFOLDS; GEOMETRY | einstein spacetimes; general relativistic spacetimes; killing vector field; perfect fluid spacetime; Ricci solitons | Relativity; Shrinkage; Vectors; Einstein spacetime; General relativistic spacetime; Killing vector field; Perfect fluid; Perfect fluid spacetime; Relativistics; Ricci soliton; Spacetime; Vector fields; Solitons | English | 2023 | 2023-06-01 | 10.1088/1402-4896/accf41 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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