연구성과로 돌아가기
2024 연구성과 (156 / 286)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Review | Interpretation of PD-L1 expression in gastric cancer : summary of a consensus meeting of Korean gastrointestinal pathologists | Nivolumab plus chemotherapy in the first-line setting has demonstrated clinical efficacy in patients with human epidermal growth factor receptor 2-negative advanced or metastatic gastric cancer, and is currently indicated as a standard treatment. Programmed death-ligand 1 (PD-L1) expression is an important biomarker for predicting response to anti-programmed death 1/PD-L1 agents in several solid tumors, including gastric cancer. In the CheckMate-649 trial, significant clinical improvements were observed in patients with PD-L1 combined positive score (CPS) >= 5, determined using the 28-8 pharmDx assay. Accordingly, an accurate interpretation of PD-L1 CPS, especially at a cutoff of 5, is important. The CPS method evaluates both immune and tumor cells and provides a comprehensive assessment of PD-L1 expression in the tumor microenvironment of gastric cancer. However, CPS evaluation has several limitations, one of which is poor interobserver concordance among pathologists. Despite these limitations, clinical indications relying on PD-L1 CPS are increasing. In response, Korean gastrointestinal pathologists held a consensus meeting for the interpretation of PD-L1 CPS in gastric cancer. Eleven pathologists reviewed 20 PD-L1 slides with a CPS cutoff close to 5, stained with the 28-8 pharmDx assay, and determined the consensus scores. The issues observed in discrepant cases were discussed. In this review, we present cases of gastric cancer with consensus PD-L1 CPS. In addition, we briefly touch upon current practices and clinical issues associated with assays used for the assessment of PD-L1 expression in gastric cancer. | Ahn, Soomin; Kwak, Yoonjin; Kwon, Gui Young; Kim, Kyoung-Mee; Kim, Moonsik; Kim, Hyunki; Park, Young Soo; Oh, Hyeon Jeong; Lee, Kyoungyul; Lee, Sung Hak; Lee, Hye Seung | Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol & Translat Genom, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Pathol, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea; Seoul Clin Labs, Dept Pathol, Yongin, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Yonsei Univ, Coll Med, Dept Pathol, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Pathol, Seongnam, South Korea; Seegene Med Fdn, Pathol Ctr, Seoul, South Korea; Catholic Univ Korea, Dept Hosp Pathol, Seoul St Marys Hosp, Coll Med, Seoul, South Korea | ; Kim, Ju-Hyoung/N-1450-2019; Kwak, Yoonjin/HOI-0139-2023; Lee, Hye Seung/LZI-3726-2025 | 54893655800; 56049775700; 57560463100; 56155892100; 57195918515; 57965263900; 59135056800; 56704197500; 57194431661; 57203597873; 57102095800 | hye2@snu.ac.kr; | JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE | J PATHOL TRANSL MED | 2383-7837 | 2383-7845 | 58 | 3 | ESCI | PATHOLOGY | 2024 | 3 | 30.6 | 1.24 | 2025-05-07 | 4 | 4 | Gastric neoplasms; PD-L1; Combined positive score (CPS) | PLUS CHEMOTHERAPY; NIVOLUMAB; JUNCTION | Combined positive score; Gastric neoplasms; PD-L1 | programmed death 1 ligand 1; assay; consensus; consensus development; human; interrater reliability; Korean (people); pathologist; protein expression; Review; stomach cancer | English | 2024 | 2024-05 | 10.4132/jptm.2024.03.15 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Smart Electrical Screening Methodology for Channel Hole Defects of 3D Vertical NAND (VNAND) Flash Memory | In order to successfully achieve mass production in NAND flash memory, a novel test procedure has been proposed to electrically detect and screen the channel hole defects, such as Not-Open, Bowing, and Bending, which are unique in high-density 3D NAND flash memory. Since channel hole defects lead to catastrophic failure (i.e., malfunction of basic NAND operations), detecting and screening defects in advance is one of the key challenges of guaranteeing the quality of flash products in the NAND manufacturing process. Based on analysis of the physical and electrical mechanisms of the channel hole defect, we have developed a two-step test procedure that consists of pattern-based and stress-based screen methodologies. By optimizing test patterns depending on the type of defect, the pattern-based screen is effective for detecting the type of Hard channel hole defects. The stress-based screen is carefully implemented to detect hidden Soft channel hole defects without degrading the reliability of NAND flash memory. In addition, we have attempted to further optimize the current version of our technique to minimize test time overhead, thus enabling 72.2% improvement in total test time. Experimental results using real 160 3D NAND flash chips show that our technique can efficiently detect and screen out various types of channel hole defects with minimum test time and negligible degradation in the flash reliability. | Kim, Beomjun; Seo, Gyeongseob; Kim, Myungsuk | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 37224, South Korea | 57743131700; 58958257600; 57194859467 | beomjun0816@knu.ac.kr;syhbong9@knu.ac.kr;ms.kim@knu.ac.kr; | ENG | ENG-BASEL | 2673-4117 | 5 | 1 | ESCI | ENGINEERING, MULTIDISCIPLINARY | 2024 | 2.4 | 30.6 | 0.93 | 2025-05-07 | 3 | 3 | 3D NAND flash memory; test methodology; screen; channel hole; defect; mass production; quality control | 3D NAND flash memory; channel hole; defect; mass production; quality control; screen; test methodology | English | 2024 | 2024-03 | 10.3390/eng5010027 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | The context of Songdok: Two purposes of traditional Korean education | This study explores the educational meaning of Songdok in traditional Korean education. Songdok refers to the act of memorizing text completely while reading it aloud; however, in traditional Korean education, it used to symbolize 'learning' itself. Historically, Songdok was regarded in extreme terms: being criticized as low-level memorization or encouraged as a religious ritual. In the Goryeo Dynasty, when civil service exams were introduced, Songdok was performed to memorize Confucian textbooks solely for passing the exam. However, its status changed in the mid-1600s because of an educational reform movement by Neo-Confucian fundamentalists. Given the widespread perception in South Korea that 'imitating a saint is a way of learning', Songdok has been elevated as part of moral consciousness. Here, we discuss how Songdok takes on two opposing educational objectives: One is passing the exam, and the other is imitating a saint. An examination of Songdok provides insightful perspectives on Korean education, especially regarding sluggish moral education. | Song, Sujin; Kim, Sanghyun | Kyungpook Natl Univ, Inst Humanities Studies, 80 Daehak Ro, Daegu, South Korea; Kyungpook Natl Univ, Dept Educ, 80 Daehak Ro, Daegu, South Korea | 58097318300; 58097318400 | sushi79@knu.ac.kr;shkim70@knu.ac.kr; | EDUCATIONAL PHILOSOPHY AND THEORY | EDUC PHILOS THEORY | 0013-1857 | 1469-5812 | 56 | 1 | SSCI | EDUCATION & EDUCATIONAL RESEARCH | 2024 | 1.8 | 30.6 | 0 | 2025-04-16 | 0 | 0 | Purpose of education; Neo-Confucianism; Songdok; civil service examination | civil service examination; Neo-Confucianism; Purpose of education; Songdok | English | 2024 | 2024-01-02 | 10.1080/00131857.2023.2175670 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Accommodation-capable holographic waveguide head-up display with extended field of view | Augmented reality (AR) displays are enhancing user experiences by offering immersive three-dimensional (3D) content, with head-up display (HUD) being a prime application for driving safety. To enable AR-HUDs to provide sufficient information to driver, it is essential to ensure a wide field of view (FOV). Traditional methods like the magnifier principle have limitations stemming from optical aberrations and bulky form factor. Recently, optical waveguide has been used as pupil expander, which has attracted increasing attention as an optical element for compact form factor and exit-pupil expansion. However, waveguide display as exit-pupil expander only offer 2D images with infinite depth, causing mismatch issue between virtual content and real scenes. In this paper, we propose a lensless holographic waveguide display consisting of a laser light source, a spatial light modulator (SLM), a waveguide to generate accommodation-capable images, effectively extending FOV. The key distinction of this research lies in the optical design of the waveguide, which defines multiple shifted copies of the modulated wavefield as replicated virtual SLMs. A formalized algorithm is devised based on a bold assumption that numerous virtual SLMs replicated by a waveguide are considered as a single ultra-high resolution SLM. The effectiveness of the algorithm has been demonstrated through extensive validation through numerical observation simulations and optical experiments. Notably, optical experiments convincingly demonstrate the system's ability to produce accommodation-capable true 3D content, with a four-fold extension of FOV compared to a single SLM at an observation distance of 150 mm. Additional optical experiments highlight the successful integration of AR technology, an important component for automotive HUD. | Moon, Woonchan; Jeon, Hosung; Na, Sehwan; Kim, Hwi; Hahn, Joonku | Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehakro, Daegu 41566, South Korea; Korea Univ, Coll Sci & Technol, Dept Elect & Informat Engn, Sejong Campus,2511 Sejong Ro, Sejong 30019, South Korea | 56340460500; 56663784700; 57696494800; 8933596300; 10142501600 | jhahn@knu.ac.kr; | DISPLAYS | DISPLAYS | 0141-9382 | 1872-7387 | 81 | SCIE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION;OPTICS | 2024 | 3.4 | 30.8 | 1.97 | 2025-04-16 | 6 | 5 | NEAR-EYE DISPLAY; DESIGN | Aberrations; Approximation theory; Augmented reality; Holographic displays; Light modulators; Optical design; 3D content; Extended field of views; Field of views; Form factors; Head-UpDisplay; Heads-up-display; Immersive; Optical experiments; Spatial light modulators; Users' experiences; Light sources | English | 2024 | 2024-01 | 10.1016/j.displa.2023.102617 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Clinical Practice Recommendations for the Use of Next-Generation Sequencing in Patients with Solid Cancer: A Joint Report from KSMO and KSP | In recent years, next-generation sequencing (NGS)-based genetic testing has become crucial in cancer care. While its primary objective is to identify actionable genetic alterations to guide treatment decisions, its scope has broadened to encompass aiding in pathological diagnosis and exploring resistance mechanisms. With the ongoing expansion in NGS application and reliance, a compelling necessity arises for expert consensus on its application in solid cancers. To address this demand, the forthcoming recommendations not only provide pragmatic guidance for the clinical use of NGS but also systematically classify actionable genes based on specific cancer types. Additionally, these recommendations will incorporate expert perspectives on crucial biomarkers, ensuring informed decisions regarding circulating tumor DNA panel testing. | Kim, Miso; Shim, Hyo Sup; Kim, Sheehyun; Lee, In Hee; Kim, Jihun; Yoon, Shinkyo; Kim, Hyung-Don; Park, Inkeun; Jeong, Jae Ho; Yoo, Changhoon; Cheon, Jaekyung; Kim, In-Ho; Lee, Jieun; Hong, Sook Hee; Park, Sehhoon; Jung, Hyun Ae; Kim, Jin Won; Kim, Han Jo; Cha, Yongjun; Lim, Sun Min; Kim, Han Sang; Lee, Choong-Kun; Kim, Jee Hung; Chun, Sang Hoon; Yun, Jina; Park, So Yeon; Lee, Hye Seung; Cho, Yong Mee; Nam, Soo Jeong; Na, Kiyong; Yoon, Sun Och; Lee, Ahwon; Jang, Kee-Taek; Yun, Hongseok; Lee, Sungyoung; Kim, Jee Hyun; Kim, Wan-Seop | Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Dept Pathol, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Genom Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Oncol Hematol, Daegu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Div Med Oncol,Dept Internal Med, Seoul St, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Div Hematol Oncol,Dept Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, South Korea; Soonchunhyang Univ, Dept Internal Med, Div Oncol & Hematol, Cheonan Hosp, Cheonan, South Korea; Natl Canc Ctr, Ctr Colorectal Canc, Div Med Oncol, Goyan, South Korea; Yonsei Univ, Coll Med, Yonsei Canc Ctr, Div Med Oncol,Dept Internal Med, Seoul, South Korea; Yonsei Univ, Gangnam Severance Hosp, Coll Med, Div Med Oncol,Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Bucheon St Marys Hosp, Dept Internal Med, Div Med Oncol,Coll Med, Seoul, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Med, Div Hematol Oncol, Bucheon, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Pathol, Seongnam, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Pathol, Seoul, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp, Coll Med, Dept Pathol, Seoul, South Korea; Catholic Univ Korea, Dept Hosp Pathol, Seoul St Marys Hosp, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pathol & Translat Genom, Seoul, South Korea; Konkuk Univ, Med Ctr, Sch Med, Dept Pathol, 120-1 Neungdong Ro, Seoul 05030, South Korea | ; Kim, Jong/G-7779-2012; Lee, JK/J-6143-2012; Kim, Han Sang/R-3768-2019; Lee, Choong-kun/MYS-5687-2025; 김, 수중/JED-7162-2023; Kim, Dong-Wan/J-5391-2012; Kim, Siwon/KHX-9078-2024; Kim, Jee/J-5441-2012; Shim, Hyo/ABI-6190-2020; Kim, Jin Il/JWP-3629-2024; Na, Kiyong/V-1795-2018; Lee, Hye Seung/LZI-3726-2025; Park, Sung/J-2756-2012 | 55193756000; 57449802100; 57216683239; 57191881516; 57222101434; 27068097600; 56526231200; 25947690900; 57022763500; 22954694200; 57203287161; 55477690000; 58067353600; 25654872300; 56521848600; 35272249400; 58205826700; 57105039000; 57203061340; 56446114500; 57210812990; 57196253383; 57212197994; 55111801500; 35605178100; 57222879038; 57102095800; 57216074751; 46961277200; 55267026000; 36009666500; 35218106600; 10140921200; 56803204100; 55716390100; 56004266300; 55347105100 | jhkimmd@snu.ac.kr;wskim@kuh.ac.kr; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 56 | 3 | SCIE | ONCOLOGY | 2024 | 3.8 | 30.8 | 0 | 2025-05-07 | 1 | 1 | Next -generation sequencing; Solid cancer; Precision medicine; Korea | CELL LUNG-CANCER; DABRAFENIB PLUS TRAMETINIB; CIRCULATING TUMOR DNA; PHASE-II TRIAL; METASTATIC BREAST-CANCER; MICROSATELLITE INSTABILITY DETECTION; GASTROINTESTINAL STROMAL TUMORS; HOMOLOGOUS RECOMBINATION GENES; PROGRESSION-FREE SURVIVAL; OPEN-LABEL | Korea; Next-generation sequencing; Precision medicine; Solid cancer | Biomarkers, Tumor; Circulating Tumor DNA; Genetic Testing; High-Throughput Nucleotide Sequencing; Humans; Neoplasms; Practice Guidelines as Topic; circulating tumor DNA; circulating tumor DNA; tumor marker; Article; blood sampling; bone sarcoma; cancer genetics; cancer patient; central nervous system tumor; clinical practice guideline; gene identification; genetic screening; high throughput sequencing; homologous recombination; human; Korea; microsatellite instability; renal cell carcinoma; soft tissue sarcoma; solid malignant neoplasm; tumor mutational burden; diagnosis; genetics; neoplasm; practice guideline; procedures | English | 2024 | 2024-07 | 10.4143/crt.2023.1043 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Development of optical coherence tomography incorporated image processing algorithms for the multidimensional assessment of concealed enamel micro-crack | Enamel microcracks (EMCs) are tiny fractures that occur in the outer layer of teeth, allowing some extrinsic stains and leading to an unaesthetic tooth. Additionally, the EMCs enhance the accumulation of plaque and thus EMCs could be highly suspectable zones for caries development. Therefore, the assessment of EMCs is crucial for early diagnosis and to prevent unwanted damage to teeth. In this study, a concealed EMCs detection and lengthmeasuring algorithm, and an EMCs width -measuring algorithm were applied for optical coherence tomography (OCT) image analysis to assess the EMCs progression in both length and width. Additionally, a surface noiseremoving algorithm was developed to obtain a better visualization of OCT cross-sectional and volumetric images. The developed algorithms were successfully used to detect concealed EMCs and track their progression in both length and width directions before and after the orthodontic treatment. Obtained results revealed a microscale progression of EMCs in both length and width directions after the orthodontic treatment, where the averaged progression of EMCs in length and width were 712.5 and 92.75 mu m, respectively. Therefore, highresolution, non-invasive OCT imaging with developed image processing algorithms can be a fruitful solution to use as a diagnostic tool to monitor the precise coordinates of concealed EMCs throughout the orthodontic treatment. | Abu Saleah, Sm; Cho, Hoseong; Luna, Jannat Amrin; Seong, Daewoon; Wijesinghe, Ruchire Eranga; Han, Sangyeob; Kim, Shinheon; Jeon, Mansik; Kim, Jeehyun | Kyungpook Natl Univ, ICT Convergence Res Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect & Elect Engn, 80,Daehak Ro, Daegu 41566, South Korea; Sri Lanka Inst Informat Technol, Fac Engn, Dept Elect & Elect Engn, Malabe 10115, Sri Lanka; Sri Lanka Inst Informat Technol, Ctr Excellence Intelligent Informat Elect & Transm, Malabe 10115, Sri Lanka | Cho, Ho-Seong/K-8386-2015; Wijesinghe, Ruchire/K-3797-2016 | 59154305300; 57209416599; 59154804900; 57212512353; 57214877268; 57193695305; 57226603736; 24171094000; 7601373350 | msjeon@knu.ac.kr; | INFRARED PHYSICS & TECHNOLOGY | INFRARED PHYS TECHN | 1350-4495 | 1879-0275 | 140 | SCIE | INSTRUMENTS & INSTRUMENTATION;OPTICS;PHYSICS, APPLIED | 2024 | 3.4 | 30.8 | 0 | 2025-05-07 | 0 | 0 | Optical coherence tomography; Optical Imaging; Image processing algorithm; Enamel micro-cracks; Orthodontic treatment | BOND STRENGTH; ORTHODONTIC TREATMENT; CERAMIC BRACKETS; IN-VIVO; TEETH; DEMINERALIZATION; MICROCRACKS; RETENTION; DIAGNOSIS; BEHAVIOR | Enamel micro-cracks; Image processing algorithm; Optical coherence tomography; Optical Imaging; Orthodontic treatment | Damage detection; Diagnosis; Microcracks; Optical data processing; Optical tomography; Caries development; Early diagnosis; Enamel micro-crack; Image processing algorithm; Measuring algorithm; Micro cracks; Optical imaging; Orthodontic treatments; Outer layer; Tomography image analysis; Enamels | English | 2024 | 2024-08 | 10.1016/j.infrared.2024.105377 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Impact of Patient Sex on Adverse Events and Unscheduled Utilization of Medical Services in Cancer Patients Undergoing Adjuvant Chemotherapy: A Multicenter Retrospective Cohort Study | Purpose The female sex is reported to have a higher risk of adverse events (AEs) from cytotoxic chemotherapy. Few studies examined the sex differences in AEs and their impact on the use of medical services during adjuvant chemotherapy. This sub-study aimed to compare the incidence of any grade and grade >= 3 AEs, healthcare utilization, chemotherapy completion rate, and dose intensity according to sex. Materials and Methods This is a sub-study of a multicenter cohort conducted in Korea that evaluated the impact of healthcare reimbursement on AE evaluation in patients who received adjuvant chemotherapy between September 2013 and December 2016 at four hospitals in Korea. Results A total of 1,170 patients with colorectal, gastric, or non-small cell lung cancer were included in the study. Female patients were younger, had fewer comorbidities, and experienced less postoperative weight loss of > 10%. Females had significantly higher rates of any grade AEs including nausea, abdominal pain, stomatitis, vomiting, and neutropenia, and experienced more grade >= 3 neutropenia, nausea, and vomiting. The dose intensity of chemotherapy was significantly lower in females, and they also experienced more frequent dose reduction after the first cycle. Moreover, female patients receiving platinum-containing regimens had significantly higher rates of unscheduled outpatient visits. Conclusion Our study found that females experienced a higher incidence of multiple any-grade AEs and severe neutropenia, nausea, and vomiting, across various cancer types, leading to more frequent dose reductions. Physicians should be aware of sex differences in AEs for chemotherapy decisions. | Choi, Songji; Seo, Seyoung; Lee, Ju Hyun; Suh, Koung Jin; Kim, Ji-Won; Kim, Jin Won; Kim, Se Hyun; Kim, Yu Jung; Lee, Keun-Wook; Kim, Jwa Hoon; Kim, Tae Won; Hong, Yong Sang; Kim, Sun Young; Kim, Jeong Eun; Kim, Sang-We; Lee, Dae Ho; Lee, Jae Cheol; Choi, Chang-Min; Yoon, Shinkyo; Koh, Su-Jin; Min, Young Joo; Ahn, Yongchel; Kim, Hwa Jung; Baek, Jin Ho; Park, Sook Ryun; Kim, Jee Hyun | Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Div Hematol & Med Oncol,Coll Med, 82 Gumi Ro 173 beon gil, Seongnam 13620, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, 88 Olympic Ro 43 gil, Seoul 05505, South Korea; Korea Univ, Anam Hosp, Dept Internal Med, Div Oncol,Coll Med, Seoul, South Korea; Univ Ulsan, Ulsan Univ Hosp, Div Hematol & Oncol, Coll Med, Ulsan, South Korea; Univ Ulsan Coll Med, Gangneung Asan Hosp, Dept Hematol & Oncol, Kangnung, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Clin Epidemiol & Biostat, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Oncol Hematol, Daegu, South Korea | Kim, Jwa/AAH-9915-2021; Kim, Tae-Hee/AAN-9079-2021; Kim, Pyeong Hwa/KGM-1468-2024; Kim, Jin-Seok/AAK-5424-2020; Kim, Tae Won/GRX-7323-2022; Kim, Sung-Won/J-5409-2012; Kim, Jee/J-5441-2012; Kim, Sehyun/KDN-3343-2024; Lee, Juhyung/JQV-8143-2023; Kim, Hanjun/AAJ-7528-2021; Kim, Hyung-Ho/HZM-2707-2023; Park, Se Hoon/GMX-1199-2022 | 58701309600; 57194181893; 55992514000; 56035893600; 58033544000; 58205826700; 59228632000; 55694249900; 35205887300; 57189064876; 56504151300; 16041816900; 56579040100; 57218595065; 49061131600; 16401931900; 24825051600; 14024046800; 27068097600; 55286016300; 7202197178; 37661042100; 57049824100; 57217075847; 57197525194; 56004266300 | srpark@amc.seoul.kr;jhkimmd@snu.ac.kr; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 56 | 2 | SCIE | ONCOLOGY | 2024 | 3.8 | 30.8 | 0.67 | 2025-05-07 | 6 | 5 | Sex characteristics; Adverse events; Adjuvant chemotherapy | CELL LUNG-CANCER; GENDER-DIFFERENCES; TOXICITY; FLUOROURACIL; AGE | Adjuvant chemotherapy; Adverse events; Sex characteristics | Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Female; Humans; Lung Neoplasms; Male; Nausea; Neutropenia; Retrospective Studies; Vomiting; antineoplastic agent; antineoplastic metal complex; capecitabine; carboplatin; cisplatin; fluorouracil; gimeracil plus oteracil potassium plus tegafur; oxaliplatin; paclitaxel; vinorelbine tartrate; antineoplastic agent; abdominal pain; adjuvant chemotherapy; adolescent; adult; aged; body weight loss; cancer patient; clinical outcome; cohort analysis; colorectal cancer; comorbidity; Conference Paper; controlled study; female; health care utilization; human; incidence; Korea; major clinical study; male; nausea; neutropenia; non small cell lung cancer; patient assessment; postoperative period; reimbursement; retrospective study; sex difference; stomach cancer; vomiting; adjuvant chemotherapy; clinical trial; lung tumor; multicenter study; nausea; neutropenia; non small cell lung cancer; vomiting | English | 2024 | 2024-04 | 10.4143/crt.2023.784 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Nation-Wide Retrospective Analysis of Allogeneic Stem Cell Transplantation in Patients with Multiple Myeloma: A Study from Korean Multiple Myeloma Working Party (KMM1913) | Purpose The role of allogeneic stem cell transplantation (alloSCT) in multiple myeloma (MM) treatment remains controversial. We conducted a retrospective, multicenter, nationwide study in Korea to evaluate the outcomes of alloSCT in Asian patients with MM. Materials and Methods Overall, 109 patients with MM who underwent alloSCT between 2003 and 2020 were included in this study. Data were collected from the Korean Multiple Myeloma Working Party Registry. Results The overall response rate and stringent complete response plus complete response (CR) rates were 67.0 and 46.8%, respectively, after alloSCT. At a median follow-up of 32.5 months, the 3-year probability of progression-free survival (PFS) and overall survival (OS) rates were 69.3% and 71.8%, respectively. The 3-year probabilities of OS rates in the upfront alloSCT, tandem auto-alloSCT, and later alloSCT groups were 75.0%, 88.9%, and 61.1%, respectively. Patients who achieved CR before or after alloSCT had significantly longer OS (89.8 vs. 18 months and 89.8 vs. 15.2 months, respectively). Even though patients who did not achieve CR prior to alloSCT, those who achieve CR after alloSCT had improved PFS and OS compared to those who had no achievement of CR both prior and after alloSCT. Patients who underwent alloSCT with 1-2 prior treatment lines had improved PFS (22.4 vs. 4.5 months) and OS (45.6 vs. 15.3 months) compared to those with three or more prior treatment lines. Conclusion AlloSCT may be a promising therapeutic option especially for younger, chemosensitive patients with earlier implementation from relapse. | Shin, Ho-Jin; Kim, Do -Young; Kim, Kihyun; Min, Chang-Ki; Lee, Je-Jung; Mun, Yeung-Chul; Lee, Won-Sik; Lim, Sung -Nam; Kim, Jin Seok; Moon, Joon Ho; Kim, Da Jung; Bang, Soo -Mee; Won, Jong -Ho; Jo, Jae-Cheol; Koh, Young Il | Pusan Natl Univ, Pusan Natl Univ Hosp, Sch Med, Div Hematol Oncol,Dept Internal Med,Med Res Inst, 179 Gudeok ro, Busan 49241, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Internal Med, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hematol Hosp, Coll Med, Div Hematol,Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Hwasun, South Korea; Ewha Womans Univ, Sch Med, Dept Internal Med, Seoul, South Korea; Inje Univ, Busan Paik Hosp, Dept Internal Med, Busan, South Korea; Inje Univ, Haeundae Paik Hosp, Coll Med, Dept Internal Med, Busan, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Div Hematol,Coll Med, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Hematol Oncol, Daegu, South Korea; Kosin Univ, Coll Med, Dept Internal Med, Div Hematol Oncol, Busan, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, Div Hematol & Oncol, Seoul, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Hematol & Oncol, Ulsan, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea | Won, Jongho/AAM-8322-2021; Jo, Jae-Cheol/CAE-9453-2022; KIM, JIN/I-6927-2019 | 16239868400; 57206099586; 57199440300; 57224962914; 7601478211; 7003363716; 55556573100; 24831618100; 59089202100; 56568642700; 57195951981; 7102038069; 26434081600; 35818309200; 56450114900 | hojinja@hanmail.net; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 56 | 3 | SCIE | ONCOLOGY | 2024 | 3.8 | 30.8 | 0.47 | 2025-05-07 | 1 | 1 | Multiple myeloma; Hematopoietic stem cell transplantation; Disease status; Survival | AUTOLOGOUS TRANSPLANTATION; MARROW TRANSPLANTATION; PERIPHERAL-BLOOD; EUROPEAN GROUP; BONE-MARROW; AUTOGRAFT; OUTCOMES; IMPACT; SURVIVAL; PROGRESS | Disease status; Hematopoietic stem cell transplantation; Multiple myeloma; Survival | Adult; Aged; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Multiple Myeloma; Registries; Republic of Korea; Retrospective Studies; Survival Rate; Transplantation, Homologous; busulfan; cyclophosphamide; fludarabine; fludarabine phosphate; HLA antigen; melphalan; acute graft versus host disease; adult; allogeneic stem cell transplantation; Article; Asian; chemosensitivity; chronic graft versus host disease; controlled study; cumulative incidence; cytogenetic analysis; female; follow up; haploidentical donor; heart infarction; high risk patient; human; infection; long term survival; major clinical study; male; multiple myeloma; overall response rate; overall survival; patient history of chemotherapy; pneumonia; probability; progression free survival; retrospective study; septic shock; vein occlusion; aged; allotransplantation; clinical trial; epidemiology; hematopoietic stem cell transplantation; middle aged; mortality; multicenter study; multiple myeloma; procedures; register; South Korea; survival rate; therapy | English | 2024 | 2024-07 | 10.4143/crt.2024.074 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Oncological Outcomes in Men with Metastatic Castration-Resistant Prostate Cancer Treated with Enzalutamide with versus without Confirmatory Bone Scan | Purpose In men with metastatic castration-resistant prostate cancer (mCRPC), new bone lesions are sometimes not properly categorized through a confirmatory bone scan, and clinical significance of the test itself remains unclear. This study aimed to demonstrate the performance rate of confirmatory bone scans in a real-world setting and their prognostic impact in enzalutamide-treated mCRPC. Materials and Methods Patients who received oral enzalutamide for mCRPC during 2014-2017 at 14 tertiary centers in Korea were included. Patients lacking imaging assessment data or insufficient drug exposure were excluded. The primary outcome was overall survival (OS). Secondary outcomes included performance rate of confirmatory bone scans in a real-world setting. Kaplan-Meier analysis and multivariate Cox regression analysis were performed. Results Overall, 520 patients with mCRPC were enrolled (240 [26.2%] chemotherapy-na & iuml;ve and 280 [53.2%] after chemotherapy). Among 352 responders, 92 patients (26.1%) showed new bone lesions in their early bone scan. Confirmatory bone scan was performed in 41 patients (44.6%), and it was associated with prolonged OS in the entire population (median, 30.9 vs. 19.7 months; p < 0.001), as well as in the chemotherapy-na & iuml;ve (median, 47.2 vs. 20.5 months; p=0.011) and post-chemotherapy sub-groups (median, 25.5 vs. 18.0 months; p=0.006). Multivariate Cox regression showed that confirmatory bone scan performance was an independent prognostic factor for OS (hazard ratio 0.35, 95% confidence interval, 0.18 to 0.69; p=0.002). Conclusion Confirmatory bone scan performance was associated with prolonged OS. Thus, the premature discontinuation of enzalutamide without confirmatory bone scans should be discouraged. | Jeong, Chang Wook; Han, Jang Hee; Kwon, Dong Deuk; Joung, Jae Young; Kim, Choung-Soo; Ahn, Hanjong; Hong, Jun Hyuk; Kim, Tae-Hwan; Chung, Byung Ha; Jeon, Seong Soo; Kang, Minyong; Hong, Sung Kyu; Jung, Tae Young; Park, Sung Woo; Yun, Seok Joong; Lee, Ji Yeol; Lee, Seung Hwan; Kang, Seok Ho; Kwak, Cheol | Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Urol, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Urol, Hwasun, South Korea; Natl Canc Ctr, Ctr Prostate Canc, Goyang, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Urol, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Urol, Daegu, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Urol, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Urol, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Urol, Seongnam, South Korea; Vet Hlth Serv Med Ctr, Dept Urol, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Urol, Yangsan, South Korea; Chungbuk Natl Univ, Coll Med, Dept Urol, Cheongju, South Korea; Catholic Univ Korea, Coll Med, Dept Urol, Seoul, South Korea; Yonsei Univ, Severance Hosp, Dept Urol, Coll Med, Seoul, South Korea; Korea Univ, Coll Med, Dept Urol, Anam Hosp, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Urol, 101 Daehak Ro, Seoul 03080, South Korea | Hong, Sung/J-5722-2012; Park, Sung-Woo/N-9769-2016; Kwak, Cheol/J-2731-2012; Lee, Seung Hwan/AAE-4710-2022 | 8879131000; 57412154000; 7103159860; 57222985702; 57225900355; 8339679200; 57198628541; 57797823600; 56401513800; 7203005276; 23489077600; 24468238500; 57220669348; 57185889000; 16302421300; 57298704300; 57188553133; 7405684686; 7005639032 | mdrafael@snu.ac.kr; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 56 | 2 | SCIE | ONCOLOGY | 2024 | 3.8 | 30.8 | 0.47 | 2025-05-07 | 1 | 1 | Bone; Castration resistance; Enzalutamide; Prostatic neoplasms; Pseudoprogression; Scintigraphy | CHEMOTHERAPY-NAIVE; CLINICAL-TRIALS; RECOMMENDATIONS; DESIGN | Bone; Castration resistance; Enzalutamide; Prostatic neoplasms; Pseudoprogression; Scintigraphy | Benzamides; Humans; Male; Nitriles; Phenylthiohydantoin; Prostatic Neoplasms, Castration-Resistant; Retrospective Studies; Treatment Outcome; docetaxel; enzalutamide; medronic acid; prostate specific antigen; technetium 99m; benzamide derivative; enzalutamide; nitrile; phenylthiohydantoin; aged; androgen deprivation therapy; Article; bone lesion; bone scintiscanning; cancer chemotherapy; clinical outcome; cohort analysis; controlled study; follow up; human; major clinical study; male; metastatic castration resistant prostate cancer; multicenter study; multiple cycle treatment; overall survival; progression free survival; response evaluation criteria in solid tumors; treatment response; castration resistant prostate cancer; retrospective study; treatment outcome | English | 2024 | 2024-04 | 10.4143/crt.2023.848 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Regional disparities in green space access and associations with adult obesity: An urban-rural comparison in Florida | Despite the regional differences in green space access and adult obesity, relatively little attention has been paid to comparing the associations between green space access and adult obesity in urban and rural communities. Using a macro-level approach, we compared the spatially heterogeneous associations between green space access and adult obesity in urban and rural counties. To achieve this purpose, we employed multigroup partial least squares structural equation modeling with geographically weighed regression via a case study of 67 counties in Florida. The results showed significant urban-rural differences regarding the associations between green space access and adult obesity. These associations were spatially heterogeneous between urban and rural counties. Such findings can allow public health agencies and practitioners to better understand the regional disparities in the associations between green space access and adult obesity prevalence, which are essential to encouraging the formulation of community-based public health policies in Florida. | Kim, Jinwon; Yang, Eunjung; Jeong, Ji Youn; Thapa, Brijesh | Univ Florida, Dept Tourism Hospitality & Event Management, Gainesville, FL 32611 USA; Kyung Hee Univ, Dept Tourism Sci, Seoul, South Korea; Kyungpook Natl Univ, Dept Tourism, Daegu, South Korea; Oklahoma State Univ, Sch Hospitality & Tourism Management, Stillwater, OK 74078 USA | Jeong, Ji Youn/KBB-3881-2024; Yang, Eunjung/AAZ-7045-2021 | 56392161300; 57190248091; 57190002456; 7005935934 | jinwonkim@ufl.edu; | JOURNAL OF LEISURE RESEARCH | J LEISURE RES | 0022-2216 | 2159-6417 | 55 | 3 | SSCI | HOSPITALITY, LEISURE, SPORT & TOURISM;SOCIOLOGY | 2024 | 1.9 | 30.8 | 0.58 | 2025-04-16 | 2 | 1 | Green space access; adult obesity; regional disparity; urban-rural comparison; macro-level approach | GEOGRAPHICALLY WEIGHTED REGRESSION; PHYSICAL-ACTIVITY; BUILT ENVIRONMENT; LEISURE CONSTRAINTS; BEACH ACCESS; HEALTH; ACCESSIBILITY; FACILITIES; PROMOTION; JUSTICE | adult obesity; Green space access; macro-level approach; regional disparity; urban–rural comparison | Florida [United States]; United States; adult; greenspace; obesity; public access; rural-urban comparison; urban society | English | 2024 | 2024-05-26 | 10.1080/00222216.2023.2204885 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Real-World Outcome of First Line Atezolizumab in Extensive-Stage Small Cell Lung Cancer: A Multicenter Prospective Cohort Study | Purpose The addition of immune checkpoint inhibitors to chemotherapy has improved survival outcomes in patients with extensivestage small cell lung cancer (ES-SCLC). However, their real -world effectiveness remains unknown. Therefore, we investigated the effectiveness of atezolizumab plus chemotherapy in ES-SCLC in actual clinical settings. Materials and Methods In this multicenter prospective cohort study, patients with ES-SCLC receiving or scheduled to receive atezolizumab in combination with etoposide and carboplatin were enrolled between June 2021 and August 2022. The primary outcomes were progression -free survival (PFS) and the 1 -year overall survival (OS) rate. Results A total of 100 patients with ES-SCLC were enrolled from seven centers. Median age was 69 years, and 6% had an Eastern Cooperative Oncology Group performance status (ECOG PS) >= 2. The median PFS was 6.0 months, the 1 -year OS rate was 62.2%, and the median OS was 13.5 months. An ECOG PS of 2-3 and progressive disease as the best response were poor prognostic factors for PFS, while an ECOG PS of 2-3 and brain metastasis were associated with poor prognosis for OS. In addition, consolidative thoracic radiotherapy was found to be an independent favorable prognostic factor for OS (hazard ratio, 0.336; p=0.021). Grade >= 3 treatmentrelated adverse events were observed in 7% of patients, with treatment -related deaths occurring in 2% of patients. Conclusion We provided evidence of the favorable real -world effectiveness and safety of atezolizumab plus chemotherapy in ES-SCLC patients, including in the elderly and those with poor ECOG PS. Additional consolidative thoracic radiotherapy may also benefit ES-SCLC patients. | Choi, Myeong Geun; Kim, Yeon Joo; Lee, Jae Cheol; Ji, Wonjun; Oh, In-Jae; Lee, Sung Yong; Yoon, Seong Hoon; Lee, Shin Yup; Lee, Jeong Eun; Kim, Eun Young; Choi, Chang-Min | Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pulm & Crit Care Med, 88 Olymp Ro 43 Gil, Seoul 05505, South Korea; Ewha Womans Univ, Dept Internal Med, Coll Med, Div Pulm & Crit Care Med,Mokdong Hosp, Seoul, South Korea; Eulji Univ, Nowon Eulji Med Ctr, Dept Pulmonol, Sch Med, Seoul, South Korea; Univ Ulsan Coll Med, Asan Med Ctr, Dept Oncol, Coll Med, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Internal Med, Hwasun, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Div Pulm Allergy & Crit Care Med,Coll Med, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Div Pulmonol Allergy & Crit Care Med, Yangsan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Chungnam Natl Univ, Coll Med, Dept Internal Med, Div Pulmonol, Daejeon, South Korea; Yonsei Univ, Coll Med, Severance Hosp, Dept Internal Med,Div Pulm & Crit Care Med, Seoul, South Korea | ; Lee, Jae/AAA-2678-2021; Oh, In-Jae/AAG-5919-2020; Lee, Jeong Eun/R-8689-2019; Kim, Seung/N-5248-2019; Lee, Joo Yong/ADE-2110-2022 | 57210423283; 57311417000; 24825051600; 55256983400; 58754601500; 56734650000; 55479240500; 49863712700; 57209104622; 57361264500; 14024046800 | ccm@amc.seoul.kr; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 56 | 2 | SCIE | ONCOLOGY | 2024 | 3.8 | 30.8 | 0 | 2025-05-07 | 0 | 0 | Atezolizumab; Real-world; Small cell lung carcinoma | PROGNOSTIC-FACTORS; RANDOMIZED-TRIAL; IMMUNOTHERAPY; CHEMOTHERAPY; DOXORUBICIN; RADIATION | Atezolizumab; Real-world; Small cell lung carcinoma | Aged; Antibodies, Monoclonal, Humanized; Humans; Lung Neoplasms; Prospective Studies; Small Cell Lung Carcinoma; alanine aminotransferase; aspartate aminotransferase; atezolizumab; carboplatin; etoposide; atezolizumab; monoclonal antibody; adrenal insufficiency; adult; aged; alanine aminotransferase blood level; anorexia; Article; aspartate aminotransferase blood level; brain metastasis; cancer chemotherapy; cancer growth; cancer patient; cancer prognosis; cancer staging; cancer survival; clinical outcome; cohort analysis; colitis; constipation; coughing; diabetes mellitus; drug efficacy; ECOG Performance Status; enterocolitis; fatigue; female; hematemesis; hepatitis; human; hyperglycemia; hyponatremia; hypothyroidism; major clinical study; male; multicenter study; multiple cycle treatment; muscle weakness; nausea; neutropenia; overall survival; paralytic ileus; peripheral neuropathy; pleura effusion; pneumonia; progression free survival; prospective study; pruritus; rash; side effect; small cell lung cancer; vomiting; clinical trial; lung tumor | English | 2024 | 2024-04 | 10.4143/crt.2023.913 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | An alternative approach to estimating regional input-output tables: the KFLQ method | This study proposes an alternative approach to constructing regional input-output models (RIOMs), which are efficient tools for establishing and evaluating regional economic policies. However, the usefulness of the RIOM does not diminish the complexity and high cost burden associated with the survey-based method, including the inordinate amount of time required to construct the model. Hence, many previous studies have actively studied nonsurvey techniques. However, the problems of overestimating regional input coefficients have been highlighted as a limitation of traditional nonsurvey methods. Therefore, this study proposes a modified Flegg's location quotient formula (hereafter KFLQ) to address the limitations of previous nonsurvey methods and tests the validity of the KFLQ method through empirical analysis. In this regard, the empirical test focuses on how the distortion of input coefficients in the previous LQ-based formulas can be corrected. Ultimately, the results show that the KFLQ method yields more accurate results than those from previous LQ-based methods. | Kwon, Hana; Choi, Sung-Goan | Kyungpook Natl Univ, Dept Econ, Daegu, South Korea; Kyungpook Natl Univ, Inst Social Res, Daegu, South Korea; Andong Natl Univ, ARDI, Andong, South Korea | 58097431500; 56818153200 | khn@knu.ac.kr;sgchoi@anu.ac.kr; | ANNALS OF REGIONAL SCIENCE | ANN REGIONAL SCI | 0570-1864 | 1432-0592 | 72 | 2 | SSCI | ECONOMICS;ENVIRONMENTAL STUDIES;GEOGRAPHY;REGIONAL & URBAN PLANNING | 2024 | 2.1 | 30.9 | 1.31 | 2025-05-07 | 2 | 2 | C67; O18; R15 | LOCATION QUOTIENTS; NONSURVEY METHODS; APPROPRIATE USE; FLQ; CONSTRUCTION | C67; O18; R15 | cost analysis; economic policy; estimation method; input-output analysis; regional development; regional economy | English | 2024 | 2024-02 | 10.1007/s00168-023-01211-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Climate-related disaster exposure and regional migration | In contrast to the existing literature focusing on post-disaster regional impacts, we illustrate how the perception of disaster exposure affects regional population flows through household location decisions using a quantitative spatial economics model. More importantly, the quantitative spatial economics model helps identify critical drivers for regional migration that motivate the subsequent empirical analyses. A generalized additive model is applied to US county-level data to capture the nonlinear impact of disaster exposure on migration. The regional migration is not responsive to small and moderate disaster exposures. However, counties subject to severe disaster exposure experience significantly slower net inmigration. | Chen, Yong; Kim, Myungjin; Fouzia, Sultana | Oregon State Univ, Dept Appl Econ, 229 Ballard Hall, Corvallis, OR 97331 USA; Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea; Univ Calif Berkeley, Sch Law, Law Bldg, Berkeley, CA 94720 USA; Kyungpook Natl Univ, KNU Inst Basic Sci, KNU LAMP Res Ctr, Daegu 41566, South Korea | 55035934000; 57216929620; 59156371300 | yong.chen@oregonstate.edu;myungjin_kim@knu.ac.kr;fouzia@berkeley.edu; | ANNALS OF REGIONAL SCIENCE | ANN REGIONAL SCI | 0570-1864 | 1432-0592 | 73 | 2 | SSCI | ECONOMICS;ENVIRONMENTAL STUDIES;GEOGRAPHY;REGIONAL & URBAN PLANNING | 2024 | 2.1 | 30.9 | 0 | 2025-05-07 | 0 | 0 | NATURAL DISASTERS; ECONOMIC-IMPACT; CONSUMPTION; HURRICANES; MODELS | climate effect; location decision; natural disaster; numerical model; perception; population migration; quantitative analysis | English | 2024 | 2024-08 | 10.1007/s00168-024-01276-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Lipocalin-2 as a mediator of neuroimmune communication | Lipocalin-2, a neutrophil gelatinase-associated lipocalin, is a 25-kDa secreted protein implicated in a broad range of inflammatory diseases affecting the brain and periphery. It is a pleotropic protein expressed by various immune and nonimmune cells throughout the body. Importantly, the surge in lipocalin-2 levels in disease states has been associated with a myriad of undesirable effects, further exacerbating the ongoing pathological processes. In the brain, glial cells are the principal source of lipocalin-2, which plays a definitive role in determining their functional phenotypes. In different central nervous system pathologies, an increased expression of glial lipocalin-2 has been linked to neurotoxicity. Lipocalin-2 mediates a crosstalk between central and peripheral immune cells under neuroinflammatory conditions. One intriguing aspect is that elevated lipocalin-2 levels in peripheral disorders, such as cancer, metabolic conditions, and liver diseases, potentially incite an inflammatory activation of glial cells while disrupting neuronal functions. This review comprehensively summarizes the influence of lipocalin-2 on the exacerbation of neuroinflammation by regulating various cellular processes. Additionally, this review explores lipocalin-2 as a mediator of neuroimmune crosstalk in various central nervous system pathologies and highlights the role of lipocalin-2 in carrying inflammatory signals along the neuroimmune axis. | Afridi, Ruqayya; Kim, Jae-Hong; Bhusal, Anup; Lee, Won-Ha; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, 680 Gukchaebosang St, Daegu 41944, South Korea; Kyungpook Natl Univ, Brain Korea Four KNU Convergence Educ Program Biom, 680 Gukchaebosang St, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat Biores Grp, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, 680 Gukchaebosang St, Daegu 41944, South Korea | 57200759784; 55926599800; 57200274141; 57205609794; 7005114595 | ksuk@knu.ac.kr; | JOURNAL OF LEUKOCYTE BIOLOGY | J LEUKOCYTE BIOL | 0741-5400 | 1938-3673 | 116 | 2 | SCIE | CELL BIOLOGY;HEMATOLOGY;IMMUNOLOGY | 2024 | 3.1 | 31.1 | 0.66 | 2025-05-07 | 5 | 3 | astrocytes; lipocalin-2; microglia; neuroimmune axis; neuroinflammation; peripheral diseases | GELATINASE-ASSOCIATED LIPOCALIN; ASTROCYTE-DERIVED LIPOCALIN-2; CENTRAL-NERVOUS-SYSTEM; BRAIN-INJURY; LIVER-FAILURE; PROTEIN; AXIS; NEUROINFLAMMATION; APOPTOSIS; EXCITOTOXICITY | astrocytes; lipocalin-2; microglia; neuroimmune axis; neuroinflammation; peripheral diseases | Animals; Humans; Lipocalin-2; Neuroglia; Neuroimmunomodulation; Neuroinflammatory Diseases; neutrophil gelatinase associated lipocalin; LCN2 protein, human; astrocyte; drug combination; etiology; glia cell; human; immunocompetent cell; microglia; nervous system inflammation; neurotoxicity; nonhuman; phenotype; review; animal; glia; immunology; immunomodulation; metabolism; nervous system inflammation | English | 2024 | 2024-01-09 | 10.1093/jleuko/qiad157 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | 3D-printed shadow masks for micro-patterned electrodes | Microfabrication is critical to the advancement of lab-on-chip devices by enabling the creation of high-precision, complex electrode structures. Traditional photolithography, commonly used to fabricate micro-patterned electrodes, involves complex and multi-step processes that can be costly and time-consuming. In this research, we present a method using 3D-printed shadow masks for electrode fabrication, offering a simpler, cost-effective alternative to traditional methods. Specifically, by leveraging a fused deposition modeling 3D printer, we demonstrate that 3D-printed shadow masks streamline rapid prototyping of micro-patterned electrodes with a range of designs, from simple lines to complex patterns. To assess the lab-on-chip functionality of the electrodes fabricated from 3D-printed shadow masks, we investigate electric field-driven assembly of microparticles in the electrodes. The micro-patterned designs of the electrodes remotely guide the assembly patterns, resulting in the formation of well-defined, multiple chains and anisotropic structures. These results suggest that 3D-printed shadow masks not only simplify the fabrication process, but also maintain the precision required for advanced lab-on-chip applications. The proposed method could pave the way for more accessible and scalable manufacturing of the complex micro-patterned electrodes. | Cha, Chanwook; Jo, Eunhwa; Kim, Yeongjun; Choi, Andrew Jaeyong; Han, Koohee | Kyungpook Natl Univ, Dept Chem Engn, Daegu, South Korea; Gachon Univ, Sch Comp, Dept AI SW, 1342 Seongnam Daero, Seongnam 13306, South Korea | Choi, Andrew/HII-6799-2022 | 59396777400; 59397166200; 58939509300; 57204794048; 57192061329 | andrewjchoi@gachon.ac.kr;han.koohee@knu.ac.kr; | RSC ADVANCES | RSC ADV | 2046-2069 | 14 | 47 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.6 | 31.2 | 0 | 2025-05-07 | 0 | 0 | Electrodes; Masks; Microfabrication; Microoptics; Rapid prototyping; Surface discharges; Complex electrode; Complex steps; Electrode structure; High-precision; Lab-on-chip devices; Lab-on-chips; Micro-fabrication; Micro-patterned electrodes; Multisteps; Shadow mask; Fused Deposition Modeling | English | 2024 | 2024-10-29 | 10.1039/d4ra06298a | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: