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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Trampoline Stiffness Estimation by Using Robotic System for Quantitative Evaluation of Jumping Exercises | Trampolines are recognized as a valuable tool in exercise and rehabilitation due to their unique properties like elasticity, rebound force, low-impact exercise, and enhancement of posture, balance, and cardiopulmonary function. To quantitatively assess the effects of trampoline exercises, it is essential to estimate factors such as stiffness, elements influencing jump dynamics, and user safety. Previous studies assessing trampoline characteristics had limitations in performing repetitive experiments at various locations on the trampoline. Therefore, this research introduces a robotic system equipped with foot-shaped jigs to evaluate trampoline stiffness and quantitatively measure exercise effects. This system, through automated, repetitive movements at various locations on the trampoline, accurately measures the elastic coefficient and vertical forces. The robot maneuvers based on the coordinates of the trampoline, as determined by its torque and position sensors. The force sensor measures data related to the force exerted, along with the vertical force data at X, Y, and Z coordinates. The model's accuracy was evaluated using linear regression based on Hooke's Law, with Mean Absolute Error (MAE), Root Mean Square Error (RMSE), and Correlation Coefficient Squared (R-squared) metrics. In the analysis including only the distance between X and the foot-shaped jigs, the average MAE, RMSE, and R-squared values were 17.9702, 21.7226, and 0.9840, respectively. Notably, expanding the model to include distances in X, Y, and between the foot-shaped jigs resulted in a decrease in MAE to 15.7347, RMSE to 18.8226, and an increase in R-squared to 0.9854. The integrated model, including distances in X, Y, and between the foot-shaped jigs, showed improved predictive capability with lower MAE and RMSE and higher R-squared, indicating its effectiveness in more accurately predicting trampoline dynamics, vital in fitness and rehabilitation fields. | Park, Gunseok; Choi, Seung-Hwan; Kim, Chang-Hyun; Kim, Min Young; Lee, Suwoong; Shirinzadeh, Bijan | Korea Inst Ind Technol, Daegyeong Div, Adv Mechatron Res Grp, Daegu 42994, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Res Ctr Neurosurg Robot Syst, Daegu 41566, South Korea | ; Choi, Seunghwan/KGL-5439-2024 | 58704660700; 55802893400; 57199973187; 56739349100; 57188756166 | rjstjr010@kitech.re.kr;csw1496@kitech.re.kr;limition@kitech.re.kr;mykim@ee.knu.ac.kr;lee@kitech.re.kr; | SENSORS | SENSORS-BASEL | 1424-8220 | 23 | 24 | SCIE | CHEMISTRY, ANALYTICAL;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2023 | 3.4 | 30.9 | 0 | 2025-06-25 | 0 | 0 | trampoline; robot manipulation; elastic constant and force estimation; Hooke's law; linear regression | MINI-TRAMPOLINE | elastic constant and force estimation; Hooke’s law; linear regression; robot manipulation; trampoline | Exercise; Foot; Linear Models; Lower Extremity; Robotic Surgical Procedures; Mean square error; Robotics; Elastic constant and force estimation; Force estimation; Hooke’s law; Mean absolute error; Quantitative evaluation; Robot manipulation; Robotic systems; Root mean square errors; Trampoline; Vertical force; exercise; foot; lower limb; robot assisted surgery; statistical model; Stiffness | English | 2023 | 2023-12 | 10.3390/s23249645 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Wave Dispersion Behavior in Quasi-Solid State Concrete Hydration | This paper aims to investigate wave dispersion behavior in the quasi-solid state of concrete to better understand microstructure hydration interactions. The quasi-solid state refers to the consistency of the mixture between the initial liquid-solid stage and the hardened stage, where the concrete has not yet fully solidified but still exhibits viscous behavior. The study seeks to enable a more accurate evaluation of the optimal time for the quasi-liquid product of concrete using both contact and noncontact sensors, as current set time measurement approaches based on group velocity may not provide a comprehensive understanding of the hydration phenomenon. To achieve this goal, the wave dispersion behavior of P-wave and surface wave with transducers and sensors is studied. The dispersion behavior with different concrete mixtures and the phase velocity comparison of dispersion behavior are investigated. The analytical solutions are used to validate the measured data. The laboratory test specimen with w/c = 0.5 was subjected to an impulse in a frequency range of 40 kHz to 150 kHz. The results demonstrate that the P-wave results exhibit well-fitted waveform trends with analytical solutions, showing a maximum phase velocity when the impulse frequency is at 50 kHz. The surface wave phase velocity shows distinct patterns at different scanning times, which is attributed to the effect of the microstructure on the wave dispersion behavior. This investigation delivers profound knowledge of hydration and quality control in the quasi-solid state of concrete with wave dispersion behavior, providing a new approach for determining the optimal time of the quasi-liquid product. The criteria and methods developed in this paper can be applied to optimal timing for additive manufacturing of concrete material for 3D printers by utilizing sensors. | Wu, Yin Chao; Kang, Sanggoo; Jeong, Yeongseok; David, Dafnik Saril Kumar; Ham, Suyun | Univ Texas Arlington, Dept Civil Engn, Arlington, TX 76019 USA; Kyungpook Natl Univ, Sch Architecture, Daegu 37224, South Korea | 57216820016; 57211517696; 57221493589; 57195634576; 55058913500 | s.ham@uta.edu; | SENSORS | SENSORS-BASEL | 1424-8220 | 23 | 8 | SCIE | CHEMISTRY, ANALYTICAL;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2023 | 3.4 | 30.9 | 0.26 | 2025-06-25 | 2 | 2 | wave dispersion; wave scattering; hydration; analytical solution; sensors; P-wave; surface wave; inhomogenous medium | MULTIPLE-SCATTERING; FRESH; PROPAGATION; ATTENUATION; MORTAR | analytical solution; hydration; inhomogenous medium; P-wave; sensors; surface wave; wave dispersion; wave scattering | 3D printing; Concrete mixtures; Dispersion (waves); Microstructure; Phase velocity; Quality control; Seismic waves; Surface waves; Analytical solution; Concrete hydration; Dispersion behavior; Inhomogenous media; Liquid products; Optimal time; P waves; Quasi-solid state; Wave dispersion; Wave scattering; Hydration | English | 2023 | 2023-04 | 10.3390/s23083947 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Don't "Weight" to Board: Augmenting Vision-based PassengerWeight Prediction via Viscoelastic Mat | Airlines overestimate the weight of their passengers by simply assigning a constant weight for everyone, causing each plane to burn more fuel than needed to carry the extra weight. Accurately estimating the passenger weights is a difficult problem for airlines as naively weighing all passengers with scales is impractical in already busy airports. Hence, we propose CamScale, a novel vision-based weight inference system that is augmented by an off-the-shelf viscoelastic mat (e.g., memory foam mat). CamScale takes the video feed of the mat placed on the floor as the passengers walk over it. It utilizes the inherent strain, or deformation of the mat due to the passengers' footsteps to infer their weights. CamScale is advantageous because it does not incur additional weighing time, while being cost-effective and accurate. We evaluate CamScale through real-world experiments by deploying RGB and infrared cameras and inviting 36 participants to walk a total of more than 17,000 steps over viscoelastic mats, equivalent to walking approximately 13.1 km. We demonstrate that CamScale is able to accurately estimate an individual's weight with an average error of 1.12 kg. © 2023 ACM. | Lee, Jong Taek; Lim, Yu Kai; Pan, Shijia; Han, Jun | Kyungpook National University, Daegu, South Korea; Defence Science and Technology Agency, Singapore, Singapore; University of California, Merced, Merced, CA, United States; Yonsei University, Seoul, South Korea | 24341317500; 57217247407; 55582579800; 56170952600 | jun.han@yonsei.ac.kr; | Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies | PROC ACM INTERACT MO | N/A | 2474-9567 | 6 | 4 | ESCI | COMPUTER SCIENCE, INFORMATION SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2023 | 3.6 | 31.0 | 0.22 | 2025-06-25 | 2 | deep learning; sensing; video; weight estimation | Air transportation; Deep learning; Viscoelasticity; Weighing; Constant weight; Deep learning; Foam mats; Inference systems; Inherent deformation; Sensing; Video; Viscoelastics; Vision based; Weights estimation; Cost effectiveness | English | Final | 2023 | 10.1145/3569465 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Geospatial analysis of short term shoreline change behavior between Subarnarekha and Rasulpur estuary, east coast of India using intelligent techniques (DSAS) | A geospatial analysis of shoreline change pattern is most significant parameter to understand the behavioral interaction between land and sea water. Geospatial analyses using various statistical and quantitative methods which are more applicable, accurate and dependable to measures the spatio-temporal trend of erosion accretion and estimate the change rate of shoreline. Remote sensing and GIS techniques have been used for the identification of shoreline change over the various time scales. To identify the rate Digital Shoreline Analysis System (DSAS) was applied in the current research. The present study aimed to identify the trend of coastal erosion accretion during 43 years (1975-2018) which is divided into four short term period (1975-1988, 1988-2000, 2000-2010 and 2010-2018) between the coastal stretch of Subarnarekha and Rasulpur estuary along Bay of Bengal using multi temporal satellite images. The accurate shoreline position has been delineated by the histogram threshold method using the images of Landsat Multi Spectral Scanner, Thematic Mapper and Enhanced Thematic Mapper. The shoreline change rate has been calculated based on cast transect method through some statistical techniques such as End Point Rate (EPR) and Net Shoreline Movement (NSM) in GIS application. 70.42 km long coastal stretch along Bay of Bengal has been divided into three littoral zones (LZ) to analyze the shoreline shifting on a zone basis. From the analysis it has been observed that maximum erosion occurred between 1988 and 2000 time period in all zones. The result shows that highest rate of net shoreline movement has been found in LZ I (- 1715.71 m) in 1975-1988 and LZ III (- 1719.65 m) in 2000-2010 at Subarnarekha estuary and Junput respectively. The present study reveals that most of the accretive formation is observed in 2000-2010 and 2010-2018. Major accretion is identified in the southern part of Subarnarekha estuary, 23.93 m/year in EPR method. Maximum shades of changes was experienced in LZ I, especially in Subarnarekha estuary area. In the time span of 1975-1988 this area faced the highest erosion and highest accretion with the rate of - 78.54 m/year and 23.93 m/year respectively through EPR method. During 1988-2000, - 37.35 m/year erosional rate was found in the Subarnarekha estuary. The highest erosional rate was - 8.48 m/year in Beguran Jalpai during 1988-2000 by EPR. The maximum rate of accretion has been noticed as 7.7 m/year in LZ II in the time period of 2010-2018. | Nath, Anindita; Koley, Bappaditya; Saraswati, Subhajit; Choudhury, Tanupriya; Um, Jung-Sup; Ray, Bidhan Chandra | Jadavpur Univ, Dept Construct Engn, Salt Lake Campus, Kolkata 700106, W Bengal, India; Bankim Sardar Coll, Deaprtment Geog, South 24 Parganas, Uttar Angad Baria 743329, W Bengal, India; Univ Petr & Energy Studies UPES, Sch Comp Sci, Informat Cluster, Dehra Dun 248007, Uttarakhand, India; Kyungpook Natl Univ, Coll Social Sci, Dept Geog, Daegu 702701, South Korea; Jadavpur Univ, Dept Chem, Main Campus, Kolkata 700032, W Bengal, India | ; Nath, Anindita/ADD-4573-2022; Um, Jung-Sup/F-5351-2018; Koley, Bappaditya/ABD-2038-2021; Choudhury, Tanupriya/AAB-8947-2020 | 57219157935; 57219158700; 12809435400; 57193140084; 35173565000; 15837829900 | aninditan286@gmail.com;bappadityakoley2012@gmail.com;tanupriya1986@gmail.com; | GEOJOURNAL | GEOJOURNAL | 0343-2521 | 1572-9893 | 88 | SUPPL 1 | ESCI | GEOGRAPHY | 2023 | 2 | 31.1 | 2.34 | 2025-06-25 | 13 | 15 | Geospatial; Shoreline change rate; Littoral Zone; End Point Rate; Net Shoreline Movement | TM DIGITAL DATA; SEA-LEVEL RISE; WATERLINE EXTRACTION; LATE QUATERNARY; SAGAR ISLAND; WEST-BENGAL; LAND-COVER; PREDICTION; POSITION; LONG | End Point Rate; Geospatial; Littoral Zone; Net Shoreline Movement; Shoreline change rate | Bay of Bengal; India; Indian Ocean; Subarnarekha Estuary; West Bengal; Beaches; Estuaries; Geographic information systems; Image enhancement; Point contacts; Remote sensing; Seawater; Statistical methods; Analysis system; End point rate; End-points; Geo-spatial; Geo-spatial analysis; Littoral zone; Net shoreline movement; Shoreline change; Shoreline change rate; Short term; coastal erosion; erosion rate; GIS; intertidal environment; Landsat; satellite imagery; shoreline change; spatiotemporal analysis; Erosion | English | 2023 | 2023-12 | 10.1007/s10708-022-10683-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Editorial Material | Special issue: Geospatial data analysis through artificial intelligence: editorial column | Choudhury, Tanupriya; Um, Jung-Sup | Symbiosis Int, Symbiosis Inst Technol, CSE Dept, Lavale HillBase Campus, Pune 412115, Maharashtra, India; Univ Petr Energy & Studies UPES, Sch Comp Sci, Bidholi Campus, Dehra Dun, Uttaranchal 248007, India; Graph Era Hill Univ, CSE Dept, Dehra Dun 248002, Uttaranchal, India; Kyungpook Natl Univ, Coll Social Sci, Dept Geog, 80Univ Rd, Daegu 702701, South Korea | ; Choudhury, Tanupriya/AAB-8947-2020; Um, Jung-Sup/F-5351-2018 | 57193140084; 35173565000 | tanupriya.choudhury@sitpune.edu.in;jsaeom@knu.ac.kr; | GEOJOURNAL | GEOJOURNAL | 0343-2521 | 1572-9893 | 88 | SUPPL 1 | ESCI | GEOGRAPHY | 2023 | 2 | 31.1 | 0.98 | 2025-06-25 | 1 | 2 | English | 2023 | 2023-12 | 10.1007/s10708-023-10985-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Comparison of immunohistochemistry and next-generation sequencing results in oncogenic PTEN missense mutations | Background: Phosphatase and tensin homolog (PTEN) is one of the most frequently mutated tumor suppressor genes in malignant tumors. Oncogenic PTEN mutations have diagnostic, prognostic, and therapeutic implications. Similar to TP53 mutations, oncogenic PTEN mutations can result from nonsynonymous missense mutations. However, there has been no detailed study on the immunostaining pattern of oncogenic PTEN missense mutations. Methods: We retrospectively selected 18 cancers (13 endometrial cancers, 2 brain tumors, 1 ovarian cancer, 1 lung cancer, and 1 cancer of unknown origin) harboring oncogenic PTEN missense mutations, which were confirmed by targeted next-generation sequencing. PTEN immunohistochemistry was conducted for all cases, and the results were compared with sequencing results.Results: The immunostaining results of PTEN missense mutations revealed a diverse pattern depending on the site of mutation and co-occurring mutation. The most frequent oncogenic PTEN mutations were R130G (4/18, 22.2 %) and R130Q (3/18, 16.7 %). Eleven cases harbored PTEN missense mutations only, whereas the remaining seven cases harbored PTEN truncating mutations and PTEN missense mutations. Complete loss of cytoplasmic expression were found in five cases, of which three had missense mutation only. PTEN R130 residue mutation alone did not showed altered PTEN immunostaining pattern in this study.Conclusions: PTEN missense mutation, which comprises a portion of oncogenic PTEN mutation, can manifest as a diverse immunostaining pattern. Complementary testing using both immunostaining and next-generation sequencing should be conducted to accurately evaluate the PTEN status in malignancy. | Kim, Moonsik; Kim, Jinhee; Seo, An Na; Jeong, Ji Yun; Park, Nora Jee-Young; Chong, Gun Oh; Hong, Dae Gy; Park, Ji Young | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Daegu 41404, South Korea | Kim, Ju-Hyoung/N-1450-2019 | 57195918515; 57789253600; 55804153700; 57205472984; 57226185359; 23099068000; 26656670100; 57210160197 | jyparkmd@knu.ac.kr; | PATHOLOGY RESEARCH AND PRACTICE | PATHOL RES PRACT | 0344-0338 | 1618-0631 | 251 | SCIE | PATHOLOGY | 2023 | 2.9 | 31.2 | 0.45 | 2025-06-25 | 1 | 2 | PTEN; Immunohistochemistry; Next-generation sequencing; Missense mutation | ENDOMETRIAL CARCINOMA | Immunohistochemistry; Missense mutation; Next-generation sequencing; PTEN | Female; High-Throughput Nucleotide Sequencing; Humans; Immunohistochemistry; Mutation; Mutation, Missense; PTEN Phosphohydrolase; Retrospective Studies; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; PTEN protein, human; Article; brain tumor; cancer growth; cancer of unknown primary site; carcinogenicity; cohort analysis; comparative study; endometrium cancer; gene expression; genetic analysis; high throughput sequencing; human; human tissue; immunohistochemistry; lung cancer; major clinical study; missense mutation; ovary cancer; PTEN gene; retrospective study; female; genetics; high throughput sequencing; immunohistochemistry; mutation | English | 2023 | 2023-11 | 10.1016/j.prp.2023.154879 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Developmental function of Piezo1 in mouse submandibular gland morphogenesis | Mechanically activated factors are important in organogenesis, especially in the formation of secretory organs, such as salivary glands. Piezo-type mechanosensitive ion channel component 1 (Piezo1), although previously studied as a physical modulator of the mechanotransduction, was firstly evaluated on its developmental function in this study. The detailed localization and expression pattern of Piezo1 during mouse submandibular gland (SMG) development were analyzed using immunohistochemistry and RT-qPCR, respectively. The specific expression pattern of Piezo1 was examined in acinar-forming epithelial cells at embryonic day 14 (E14) and E16, which are important developmental stages for acinar cell differentiation. To understand the precise function of Piezo1 in SMG development, siRNA against Piezo1 (siPiezo1) was employed as a loss-of-function approach, during in vitro organ cultivation of SMG at E14 for the designated period. Alterations in the histomorphology and expression patterns of related signaling molecules, including Bmp2, Fgf4, Fgf10, Gli1, Gli3, Ptch1, Shh, and Tgf beta-3, were examined in acinar-forming cells after 1 and 2 days of cultivation. Particularly, altered localization patterns of differentiation-related signaling molecules including Aquaporin5, E-cadherin, Vimentin, and cytokeratins would suggest that Piezo1 modulates the early differentiation of acinar cells in SMGs by modulating the Shh signaling pathway. | Pokharel, Elina; Aryal, Yam Prasad; Kim, Tae-Young; Kim, Anna; Kim, Ji-Youn; Yamamoto, Hitoshi; Cho, Sung-Won; Sohn, Wern-Joo; Kim, Jae-Young; Jung, Jae-Kwang | Kyungpook Natl Univ, Sch Dent, Dept Biochem, IHBR, Daegu 41940, South Korea; Gachon Univ, Coll Hlth Sci, Dept Dent Hyg, Incheon 21936, South Korea; Tokyo Dent Coll, Dept Histol & Dev Biol, Tokyo 1010061, Japan; Yonsei Univ, Dept Oral Biol, Div Anat & Dev Biol, Coll Dent, Seoul 03722, South Korea; Daegu Hanny Univ, Coll Cosmet & Pharmaceut, Dept K Beauty Business, Daegu 38610, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, IHBR, Daegu 41940, South Korea | CHO, Sung-Won/HDO-3680-2022; Kim, AJ/LIG-4661-2024; Kim, Ji-Youn/A-5779-2017 | 57220028220; 57202611163; 57208461628; 58112989700; 57157491000; 55725330600; 56456948900; 44161404800; 56812734700; 55970994400 | jykim91@knu.ac.kr;widenmy@knu.ac.kr; | HISTOCHEMISTRY AND CELL BIOLOGY | HISTOCHEM CELL BIOL | 0948-6143 | 1432-119X | 159 | 6 | SCIE | CELL BIOLOGY;MICROSCOPY | 2023 | 2.1 | 31.2 | 0.6 | 2025-06-25 | 3 | 3 | Acinar cell; Expression pattern; Organogenesis; Salivary gland development; Signaling modulations | CYTOKERATIN EXPRESSION; VASCULAR DEVELOPMENT; TGF-BETA; CELL; DIFFERENTIATION; MICE; TRANSDUCTION; RECEPTORS; CHANNELS | Acinar cell; Expression pattern; Organogenesis; Salivary gland development; Signaling modulations | Animals; Cell Differentiation; Ion Channels; Mechanotransduction, Cellular; Mice; Morphogenesis; Salivary Glands; Submandibular Gland; aquaporin 5; bone morphogenetic protein 2; cell adhesion molecule; cytokeratin; fibroblast growth factor 10; fibroblast growth factor 4; ion channel; piezo type mechanosensitive ion channel component 1 protein; protein Patched 1; small interfering RNA; sonic hedgehog protein; transcription factor Gli1; transcriptional activator GLI3; transforming growth factor beta3; unclassified drug; uvomorulin; vimentin; ion channel; Piezo1 protein, mouse; acinar cell; animal cell; animal experiment; animal tissue; Article; cell differentiation; controlled study; developmental stage; embryo; epithelium cell; housekeeping gene; immunohistochemistry; immunoreactivity; in vitro study; male; mechanotransduction; morphogenesis; mouse; nonhuman; organogenesis; protein expression; protein localization; real time polymerase chain reaction; submandibular gland; TUNEL assay; animal; metabolism; morphogenesis; physiology; salivary gland | English | 2023 | 2023-06 | 10.1007/s00418-023-02181-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Experiences of South Korean mothers of children with medical complexity under long-term hospitalization | Aims: To explore the experiences of South Korean mothers of their children with medical complexity under long-term hospitalization. Design: A qualitative descriptive using thematic analysis. Methods: Seven South Korean mothers of children with medical complexity underwent semi-structured interviews between February and April 2021. Data were analysed by six phases of thematic analysis. The consolidated criteria for reporting qualitative research guidelines were applied in the conduct of the research. Results: Mothers of children with medical complexity experienced a journey beginning from within their vacillating minds towards the outside world. The mother's journey during the hospitalization of their children with medical complexity began from within their vacillating minds towards achieving resilience. The mothers received various support from the family, society and hospital staff during this period of vacillation. When the mothers achieved resilience, they in turn provided support to other mothers as an act of solidarity. | An, Ji Young; Kwon, So-Hi; Choi, Hye Ri | Kyungpook Natl Univ, Chilgok Hosp, Organ Transplantat Ctr, Daegu, South Korea; Kyungpook Natl Univ, Coll Nursing, Res Inst Nursing Sci, Daegu, South Korea; Univ Hong Kong, Sch Nursing, Hong Kong, Peoples R China | Choi, Hye Ri/JCP-3393-2023 | 57952224100; 57206416770; 57289796600 | hyeripc@hku.hk; | NURSING OPEN | NURS OPEN | 2054-1058 | 10 | 3 | SCIE;SSCI | NURSING | 2023 | 2 | 31.3 | 0 | 2025-06-25 | 0 | 0 | child nursing; feminism; long-term care | CHRONIC ILLNESS; PARENTS; CARE; FAMILIES | child nursing; feminism; long-term care | Child; Female; Hospitalization; Humans; Mothers; Personnel, Hospital; Qualitative Research; Republic of Korea; article; child; clinical article; female; feminism; hospital personnel; hospitalization; human; Korean (people); long term care; mother; nursing; practice guideline; qualitative research; semi structured interview; solidarity; thematic analysis; mother; South Korea | English | 2023 | 2023-03 | 10.1002/nop2.1446 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Parental and Child Factors Associated With Internet Addiction in Children | Background: Internet addiction has negative effects on psychological development, interpersonal relationships, and social adaptation in 10-year-old elementary school students. Objective: This study aimed to identify parental and child characteristics related to Internet addiction in lower-grade elementary school children. Methods: This study used a secondary data analysis. Data from the tenth Panel Study on Korean Children were used. In total, 1224 ten-year-old elementary school students were included in the analysis. The questionnaire included general, parental, and child characteristics. Results: Of all child participants, 18.5% were in the high-risk group for Internet addiction. Lower paternal and maternal spousal satisfaction, maternal education level of high school graduate or lower, and greater permissive parenting by the mother were associated with higher odds of Internet addiction among their children. Moreover, boys and children who spent more than an hour per day without adults showed higher odds of Internet addiction. Conclusions: The results of this study indicate that the implementation of an intervention that improves parenting and family relationships and positively changes the environment in which children are brought up is necessary. | Lee, Mee Kyung; Kim, Yujeong | Merrimack Coll, Sch Nursing & Hlth Sci, N Andover, MA USA; Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, 680 Gukchabosangro, Daegu 41944, South Korea | lee, mee kyung/IRZ-9268-2023 | 58613949700; 57200941945 | yujeongkim@knu.ac.kr; | WESTERN JOURNAL OF NURSING RESEARCH | WESTERN J NURS RES | 0193-9459 | 1552-8456 | 45 | 11 | SCIE;SSCI | NURSING | 2023 | 2 | 31.3 | 0.32 | 2025-06-25 | 1 | 1 | Internet addiction disorder; parenting; family relations; child welfare | SATISFACTION; MEDIATION; CONFLICT | child welfare; family relations; Internet addiction disorder; parenting | English | 2023 | 2023-11 | 10.1177/01939459231201248 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Simulation of greenhouse energy and strawberry (Seolhyang sp.) yield using TRNSYS DVBES: A base case | This research establishes a base case scenario encompassing the energy behavior of the greenhouse and its direct influence on the yield of strawberries (Seolhyang sp.) to evaluate the performance of the greenhouse energy demand and its effect on crop yield. The objective is to develop a ventilated discretized volume building energy simulation (DVBES) that predicts energy demand, temperature, and relative humidity (RH) of a greenhouse and develop a predictive strawberry yield model that predicts the strawberry yield. This study used two single-span double-layer experimental greenhouses with different features. Experimentation was conducted in the winter season of 2021-2022 and 2022-2023. Hourly temperature, RH, and daily fuel consumption were used to validate the DVBES model. Weekly temperature, RH, solar radiation (SR), and yield were used to validate the strawberry yield model. The results show high prediction accuracy with minor errors. For a single-span double-layer greenhouse at E-W (90 degrees) orientation, the total energy demand and strawberry yield were 113.861 MJ.m(-2) and 0.466 kg.plant(-1).season(-1), respectively. The findings serve as a foundation for further research on optimizing energy consumption in greenhouse environments. This research contributes to advancing knowledge in sustainable agriculture and facilitates the transition toward a greener and more resource-conscious future. | Ogunlowo, Qazeem Opeyemi; Akpenpuun, Timothy Denen; Na, Wook Ho; Adesanya, Misbaudeen Aderemi; Rabiu, Anis; Dutta, Prabhat; Kim, Hyeon-Tae; Lee, Hyun-Woo | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Agr Civil Engn, Daegu 702701, South Korea; Fed Coll Agr Ibadan, Dept Agr & Bioenvironm Engn, PMB 5029, Ibadan, Nigeria; Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu 41566, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin 240003, Nigeria; Kyungpook Natl Univ, Dept Food Secur & Agr Dev, Daegu 702701, South Korea; Gyeongsang Natl Univ, Dept Bioind Machinery, Jinju 52828, South Korea | ; OGUNLOWO, QAZEEM/ABB-5386-2021; RABIU, Anis/JXO-1947-2024; Akpenpuun, Timothy/AAE-1168-2020; Adesanya, Misbaudeen/AAA-4664-2022 | 57265471800; 57194448083; 57211208368; 57264527200; 57264527100; 58704737600; 8662923200; 57209160180 | ogunlowoqazeem@knu.ac.kr;akpenpuun.td@unilorin.edu.ng;wooks121@knu.ac.kr;misbauadesanya@knu.ac.kr;rabiuanis@knu.ac.kr;prabhat2035@knu.ac.kr;bioani@gnu.ac.kr;whlee@knu.ac.kr; | SOLAR ENERGY | SOL ENERGY | 0038-092X | 1471-1257 | 266 | SCIE | ENERGY & FUELS | 2023 | 6 | 31.3 | 0.63 | 2025-06-25 | 6 | 7 | Base case; Energy demand; DVBES; Strawberry; Yield; TRNSYS 18 | THERMAL PERFORMANCE; TEMPERATURE; PREDICTION; PATTERNS; GROWTH; PCM | Base case; DVBES; Energy demand; Strawberry; TRNSYS 18; Yield | Energy management; Energy utilization; Fruits; Greenhouse effect; Base case; Building energy simulations; Discretized volume building energy simulation; Double layers; Energy demands; Greenhouse energy; Strawberry; TRNSYS 18; Yield; Yield models; alternative agriculture; crop yield; fuel consumption; prediction; relative humidity; solar radiation; yield response; Greenhouses | English | 2023 | 2023-12 | 10.1016/j.solener.2023.112196 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of oestrus synchronisation through ovulation delay by vaccination against foot-and-mouth disease in Hanwoo (Bos taurus coreanae) cows | BackgroundIn Korean cattle, after foot-and-mouth disease (FMD) vaccination, anovulation increases, acute immune response is stimulated. ObjectiveHere, we aimed to improve the fertility rate by ovulation delay caused by the foot-and-mouth disease vaccine. Methods160 cows (control, FMD, FMD+Gn250 and FMD+Gn500 groups, with 40 cows each) were used. We analysed the ovulation delay, ovulation rate, conception rate and acute-phase immune responses. ResultsIn the group vaccinated only with FMD, the average follicle size was maintained at 12 mm and ovulation was delayed. The ovulation rate of the FMD+Gn500 group (500 mu g gonadotropin-releasing hormone (GnRH) injections 3 days after the FMD vaccination) was the highest at 81.8%. The ovulation rate of the FMD+Gn250 group (250 mu g GnRH injections 3 days after FMD vaccination) was 54.5%, and that of the control group (not FMD vaccinated) was 53.3%. The conception rate was 52.5% (19/40) in the control group, 37.5% (15/40) in the FMD+Gn250 group, and 67.5% (27/40) in the FMD+Gn500 group. Analysis of acute-phase immune response revealed that the plasma contents of haptoglobin and serum amyloid A increased up to 7 days after vaccination against FMD in all the experimental groups, except the control group. ConclusionsWe concluded that ovulation delay can be employed to improve conception rate after FMD vaccination through a modified ovulation synchronisation method with GnRH. | Kim, Daehyun; Kwon, Woo-Sung; Ha, Jaejung; Kim, Jaejo; Kim, Danil; Lee, Wonyou; Moon, Joonho; Yi, Junkoo | Livestock Res Inst, Dept Korean Cattle Reserch, Gyeongsangbug do, South Korea; Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Gyeongsangbug do, South Korea; Anim & Plant Quarantine Agcy, Dept Anim & Plant Hyg Res, Gyeongsangbug do, South Korea; Seoul Natl Univ, Dept Designed Anim & Transplantat Res, Seoul, South Korea; Lartbio Co Ltd, Dept Trangen Cow Generat, Seoul, South Korea; GenNBio Co Ltd, Dept Transgenic Pig Generat, Gyeonggi do, South Korea; GenNBio Co Ltd, 166 Cheongbuksandan ro, Pyeongtaek si 17796, Gyeonggi do, South Korea; Livestock Res Inst, Anjeong myeon, 186 Daeryongsan ro, Yeongju, Gyeongsangbug d, South Korea | ; Moon, Joonho/KFQ-2464-2024; Yi, Junkoo/JBR-8507-2023; Kwon, Woo-Sung/J-6731-2019 | 57211228843; 54383715800; 55848402300; 36067760200; 57193925196; 57717152900; 56410309500; 56182537200 | kuma618@gmail.com;79lee38@korea.kr; | VETERINARY MEDICINE AND SCIENCE | VET MED SCI | 2053-1095 | 9 | 2 | SCIE | VETERINARY SCIENCES | 2023 | 1.8 | 31.4 | 1.1 | 2025-06-25 | 2 | 3 | conception rate; foot-and-mouth disease vaccine; gonadotropin-releasing hormone; Hanwoo (Bos taurus coreanae) cow; ovulation delay | ARTIFICIAL-INSEMINATION; PREGNANCY RATES; EMBRYO-TRANSFER; BEEF-COWS; TIME; PROSTAGLANDIN-F2-ALPHA; INVOLVEMENT; SUPPRESSION; IMPROVEMENT; FERTILITY | conception rate; foot-and-mouth disease vaccine; gonadotropin-releasing hormone; Hanwoo (Bos taurus coreanae) cow; ovulation delay | Animals; Cattle; Cattle Diseases; Estrus Synchronization; Female; Foot-and-Mouth Disease; Gonadotropin-Releasing Hormone; Ovulation; Vaccination; bioaftogen; foot and mouth disease vaccine; gonadorelin; haptoglobin; prostaglandin F2 alpha; serum amyloid A; gonadorelin; animal experiment; anovulation; Article; artificial insemination; bos taurus coreanae; controlled study; cow; estrus cycle; feeding; fertility; foot and mouth disease; immune response; nonhuman; ovary follicle; ovulation; pregnancy test; transrectal ultrasonography; vaccination; animal; bovine; cattle disease; estrus cycle; female; foot and mouth disease; ovulation; procedures; vaccination; veterinary medicine | English | 2023 | 2023-03 | 10.1002/vms3.1074 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog | BackgroundMost extramedullary plasmacytomas (EMPs) aresolitary and located in the head and neck region. They may also occur in the visceral parts of the body. ObjectivesHere, we report a case of oral EMP followed by neoplastic plasma cell metastasis to both kidneys in a neutered male Pomeranian. MethodsOral plasmacytoma recurred 11 months aftersurgical removal of an oral mass and partial maxillectomy was performed. Eighteen months after partial maxillectomy, neoplastic masses were detected in both kidneys on computed tomography. The dog died 12 months after detection of bilateral kidney neoplasms. The resected neoplastic masses were routinely processed for histopathological observation and immunohistochemistry against pan-cytokeratin, desmin, CD3, and MUM-1. ResultsThe recurred mass mainly consisted of well-differentiated plasma cells and contained a small portion of aggressive cells with malignant features. Monoclonal gammopathy was not observed on serumelectrophoresis performed to exclude multiple myeloma. The mass was composed of plasma cells with high nuclear pleomorphism and abundant mitotic figures. The neoplasm stained positive for MUM-1 with a more aggressive morphology than in oral EMP. ConclusionBased on serum biomarker and pathological observations, a diagnosis of recurrence and metastasis of oral-to-renal EMP was established. To the best of our knowledge, metastasis of oral EMP into the bilateral kidneys, as described in the current case, has not been previously reported in dogs. | Park, Kyung Ho; Kim, Tae-Un; Park, Hyun-Woo; Lee, Seoung-Woo; Baek, Su-Min; Noh, Daji; Yim, Jae-Hyuk; Lee, Young-Jin; Kim, Yeon-Gyeong; Son, Dong-Ju; Park, Sang-Joon; Choi, Seong-Kyoon; Lee, Kija; Park, Larry Chong; Park, Jin-Kyu | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu 41566, South Korea; Naason Sci Inc, Cheongju, South Korea; 24 Africa Anim Med Ctr, Daejeon, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Histol, Daegu, South Korea; DGIST, Core Prot Resources Ctr CPRC, Div Biotechnol, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med Imaging, Daegu, South Korea | 58093190400; 57214091908; 58093396900; 57218827581; 57207938426; 57188552722; 57221330255; 57491815500; 58092868500; 58092868600; 7501825941; 55505432500; 35311016000; 37002099300; 35213723500 | jinkyu820@knu.ac.kr; | VETERINARY MEDICINE AND SCIENCE | VET MED SCI | 2053-1095 | 9 | 3 | SCIE | VETERINARY SCIENCES | 2023 | 1.8 | 31.4 | 1.1 | 2025-06-25 | 3 | 3 | dog; extramedullary plasmacytoma; kidney; metastasis; recurrence | MULTIPLE-MYELOMA; SOLITARY PLASMACYTOMA; HEAD; MANAGEMENT; DIAGNOSIS; TUMOR; BONE | dog; extramedullary plasmacytoma; kidney; metastasis; recurrence | Animals; Dog Diseases; Dogs; Kidney; Male; Mouth; Plasmacytoma; Tomography, X-Ray Computed; alkaline phosphatase; C reactive protein; calcium ion; creatinine; interferon regulatory factor 4; melphalan; prednisolone; aggressive growth; anatomical concepts; animal experiment; animal tissue; anorexia; Article; B lymphocyte; bleeding; blood biochemistry; body weight loss; bulging texture; cell structure; clinical observation; computer assisted tomography; contrast enhancement; diarrhea; dog; drug withdrawal; eccentric round nuclei; echography; eosinophilic cytoplasm; follow up; hemorrhagic lesions; histopathology; hypertransaminasemia; inappetence; kidney injury; kidney metastasis; kidney parenchyma; kidney pelvis; kidney tumor; kidney vein; left caudal margin; lethargy; leukocyte count; local excision; lymphadenopathy; male; maxilla resection; metastatic renal extramedullary plasma cell tumors; microscopy; middle caudal margin; mitotic figures; mortality; mouth cavity; multinucleated cells; multiple myeloma; needle biopsy; neoplastic round cells; nonhuman; nuclear pleomorphism; oral mass in maxillary area; partial rostral maxillectomy; pathological anatomy; pink smooth elastic lesion; plasma cell; plasmacytoma; protein electrophoresis; renal dysfuncnction; renal ultrasonography; right caudal margin; severe fibrosis; side effect; side effect; soft texture; soft tissue mass; solid cellular sheet; solitary polyp like lesion; surgical margin; systemic inflammation; systemic inflammation; thin fibrous stroma; tracheal collapse; urea nitrogen blood level; vomiting; yellowish white color; animal; case report; diagnostic imaging; dog disease; kidney; mouth; pathology; plasmacytoma; veterinary medicine; x-ray computed tomography | English | 2023 | 2023-05 | 10.1002/vms3.1086 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Identification and comparison of pandemic-to-symptom networks of South Korea and the United States | BackgroundThe Coronavirus (COVID-19) pandemic resulted in a dramatic increase in the prevalence of anxiety and depression globally. Although the impact on the mental health of young adults was especially strong, its underlying mechanisms remain elusive. Materials and methodsUsing a network approach, the present study investigated the putative pathways between pandemic-related factors and anxiety and depressive symptoms among young adults in South Korea and the U.S. Network analyses were conducted on cross-country data collected during the COVID-19 lockdown period (n = 1,036). Our model included depression symptoms (PHQ-9), generalized anxiety symptoms (GAD-7), and COVID-19-related factors (e.g., COVID-19-related traumatic stress, pandemic concerns, access to medical/mental health services). ResultsThe overall structure of pandemic-to-symptom networks of South Korea and the U.S. were found to be similar. In both countries, COVID-related stress and negative future anticipation (an anxiety symptom) were identified as bridging nodes between pandemic-related factors and psychological distress. In addition, worry-related symptoms (e.g., excessive worry, uncontrollable worry) were identified as key contributors in maintaining the overall pandemic-to-symptom network in both countries. ConclusionThe similar network structures and patterns observed in both countries imply that there may exist a stable relationship between the pandemic and internalizing symptoms above and beyond the sociocultural differences. The current findings provide new insights into the common potential pathway between the pandemic and internalizing symptoms in South Korea and in the U.S. and inform policymakers and mental health professionals of potential intervention targets to alleviate internalizing symptoms. | Park, Mijeong; Seo, Deachul; Kim, Ji Geun; Lee, Gayeon; McReynolds, Larkin S.; Amsel, Lawrence; Yang, Hyunjung; Kim, Young-Hoon; Han, Sanghoon; Park, Soo Hyun; Hur, Juyoen | Yonsei Univ, Dept Psychol, Seoul, South Korea; Kyungpook Natl Univ, Dept Psychol, Daegu, South Korea; Columbia Univ, New York State Psychiat Inst, Dept Psychiat, Div Child & Adolescent Psychiat, New York, NY USA; Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA; Yonsei Univ, Univ Coll, Seoul, South Korea | Lee, Gayeon/IUP-2382-2023; Kim, Young-Hoon/E-5614-2012 | 58484487600; 58484069200; 57205490385; 58036209300; 35615077900; 8220623600; 58484757400; 56472982200; 55487826100; 7501838845; 57169663400 | jhur1@yonsei.ac.kr; | FRONTIERS IN PSYCHIATRY | FRONT PSYCHIATRY | 1664-0640 | 14 | SCIE;SSCI | PSYCHIATRY | 2023 | 3.2 | 31.4 | 0.6 | 2025-06-25 | 4 | 3 | COVID-19 pandemic; anxiety; depression; network analysis; cross-country study | ANXIETY; DEPRESSION; DISORDERS; COVID-19; COMORBIDITY | anxiety; COVID-19 pandemic; cross-country study; depression; network analysis | adult; anticipation; anxiety disorder; Article; clinical study; comparative study; controlled study; coronavirus disease 2019; cross country study; cross-sectional study; depression; distress syndrome; female; Generalized Anxiety Disorder-7; geographic distribution; health care access; human; information processing; internalizing disorder; lockdown; major clinical study; male; mental health service; mental stress; network analysis; pandemic; pandemic to symptom network; Patient Health Questionnaire 9; posttraumatic stress disorder; prevalence; risk factor; social class; South Korea; United States; young adult | English | 2023 | 2023-06-23 | 10.3389/fpsyt.2023.1161200 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | In vitro effects of omeprazole in combination with antifungal compounds against Malassezia pachydermatis | Background: Fungal and yeast infections, including those caused by Malassezia spp., are becoming increasingly difficult to treat, likely due to the occurrence of drug resistance.Objectives: This study aimed to evaluate the antifungal effects of omeprazole (OME), a proton pump inhibitor, against antifungal-resistant Malassezia pachydermatis and to investigate the potential synergistic effects between OME and other antifungal compounds.Methods: In total, 15 samples of M. pachydermatis isolated from the skin of dogs were tested. The susceptibility of M. pachydermatis to itraconazole, ketoconazole, miconazole, terbinafine and OME was assessed using a modified broth microdilution (BM) method. The in vitro efficacy of OME alone and in combination with other antifungal compounds was evaluated for all isolates using the BM chequerboard method. The data obtained were analysed using the fractional inhibitory concentration index (FICI).Results: The minimum inhibitory concentration (MIC) values of antifungal compounds and OME against quality control strain (M. pachydermatis CBS1879) were lower than the MIC90 values of same drugs against clinically collected strains. There was no significant difference in MIC values between drugs alone and combination. According to the analysis by the FICI method, no interaction was observed with OME and antifungal compounds.Conclusions: Most M. pachydermatis strains were resistant to azole antifungal compounds. OME exerted antifungal effects against Malassezia spp. and even showed good effects on antifungal-resistant strains. No synergistic effects were observed between the antifungal compounds and OME. | Shin, Juyoung; Bae, Seulgi | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, 80 Daehak Ro, Daegu 41566, South Korea | 58657606100; 55418865900 | sgbae@knu.ac.kr; | VETERINARY MEDICINE AND SCIENCE | VET MED SCI | 2053-1095 | 9 | 6 | SCIE | VETERINARY SCIENCES | 2023 | 1.8 | 31.4 | 0.37 | 2025-06-25 | 1 | 1 | antifungal compounds; antifungal resistance; Malassezia pachydermatis; proton pump inhibitor | SUSCEPTIBILITY; KETOCONAZOLE; ITRACONAZOLE; RESISTANCE; SKIN; DERMATITIS; ANTAGONISM; FURFUR | antifungal compounds; antifungal resistance; Malassezia pachydermatis; proton pump inhibitor | Animals; Antifungal Agents; Dogs; Drug Resistance, Fungal; Malassezia; Malassezia pachydermatis; Omeprazole; antifungal agent; itraconazole; ketoconazole; miconazole; omeprazole; terbinafine; antifungal agent; omeprazole; animal experiment; animal tissue; antibacterial activity; antifungal activity; antifungal resistance; antifungal susceptibility; Article; broth dilution; dog; drug efficacy; drug potentiation; fractional inhibitory concentration index; growth inhibition; IC50; Malassezia pachydermatis; Malassezia pachydermatis infection; MIC90; minimum inhibitory concentration; nonhuman; quality control; synergistic effect; animal; Malassezia; Malassezia pachydermatis | English | 2023 | 2023-11 | 10.1002/vms3.1305 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Non-cytopathic bovine viral diarrhoea virus 2 induces autophagy to enhance its replication | BackgroundBovine viral diarrhoea virus (BVDV) is an important viral pathogen that has an economic impact on the livestock industry worldwide. Autophagy is one of the earliest cell-autonomous defence mechanisms against microbial invasion, and many types of viruses can induce autophagy by infecting host cells. ObjectivesThe aim of this study was to identify the role of autophagy in the pathogenesis of non-cytopathic (ncp) BVDV2 infection. MethodsMadin-Darby bovine kidney (MDBK) cells were treated with ncp BVDV2, rapamycin, or 3-methyladenine (MA) and ncp BVDV2 and then incubated at 37 degrees C for 24 h. Cells were harvested, and the effects of autophagy were determined by transmission electron microscopy (TEM), confocal laser microscopy, western blotting and qRT-PCR. Apoptotic analysis was also performed using western blotting and flow cytometry. ResultsIn ncp BVDV2-infected MDBK cells, more autophagosomes were observed by TEM, and the number of microtubule-associated protein 1 light chain 3B (LC3B) with green fluorescent protein puncta was also increased. The ncp BVDV2-infected cells showed significantly enhanced conversion of LC3-I to LC3-II, as well as upregulation of autophagy-related proteins, including ATG5 and Beclin 1, and substantial degradation of p62/SQSTM1. These results are similar to those induced by rapamycin, an autophagy inducer. E2 protein expression, which is associated with viral replication, increased over time in ncp BVDV2-infected cells. Inhibition of autophagy by 3-MA in ncp BVDV2-infected MDBK cells downregulated the expressions of LC3-II, ATG5 and Beclin 1 and prevented the degradation of p62/SQSTM1. Moreover, the expressions of phosphorylated Akt and procaspase-3 were significantly increased in ncp BVDV2-infected cells. In addition, the mRNA level of protein kinase R (PKR) was significantly reduced in ncp BVDV2-infected cells. ConclusionsOur results demonstrate that ncp BVDV2 infection induced autophagy in MDBK cells via anti-apoptosis and PKR suppression. Therefore, autophagy may play a role in establishing persistent infection caused by ncp BVDV. | Shin, Seung-Uk; Han, Du-Gyeong; Cho, Hyung-Chul; Kim, Eun-Mi; Choi, Kyoung-Seong | Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Sci & Biotechnol, Sangju, South Korea; Korea Natl Inst Hlth, Cheongju, Chungcheongbuk, South Korea | 56967385500; 57191856417; 57219427000; 57219722950; 7403949556 | kschoi3@knu.ac.kr; | VETERINARY MEDICINE AND SCIENCE | VET MED SCI | 2053-1095 | 9 | 1 | SCIE | VETERINARY SCIENCES | 2023 | 1.8 | 31.4 | 1.47 | 2025-06-25 | 4 | 4 | autophagy; bovine viral diarrhoea virus; persistent infection; viral replication | EXPERIMENTAL-INFECTION; PERSISTENT INFECTION; INDUCED APOPTOSIS; INTERFERON; PROTEIN; KINASE; CATTLE; STRAINS; PATHWAY; BVDV | autophagy; bovine viral diarrhoea virus; persistent infection; viral replication | Animals; Autophagy; Beclin-1; Diarrhea Virus 2, Bovine Viral; Diarrhea Viruses, Bovine Viral; Sequestosome-1 Protein; Sirolimus; 3 methyladenine; autophagy related protein 5; fluorescein isothiocyanate; green fluorescent protein; protein kinase R; sirolimus; beclin 1; sequestosome 1; sirolimus; animal cell; animal experiment; apoptosis; Article; autophagosome; autophagy (cellular); bovine viral diarrhea; Bovine viral diarrhea virus 2; cell culture; cell invasion; cell viability assay; confocal laser scanning microscopy; confocal microscopy; down regulation; flow cytometry; MDBK cell line; nonhuman; real time polymerase chain reaction; transmission electron microscopy; upregulation; virus replication; Western blotting; animal; autophagy; Bovine viral diarrhea virus 1; genetics | English | 2023 | 2023-01 | 10.1002/vms3.1052 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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