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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Conditions to Terminate Reproductive Diapause of a Univoltine Insect: Ceratapion basicorne (Coleoptera: Apionidae), a Biological Control Agent of Yellow Starthistle | Ceratapion basicorne (Illiger) is a recently approved univoltine biological control agent that develops inside the rosette of yellow starthistle (Centaurea solstitialis L.), an invasive annual plant. Adult weevils normally emerge in early summer, and females are thought to be in reproductive diapause until the following spring, when they oviposit in rosettes. The long period of reproductive diapause constrains mass-rearing this weevil because only one generation per year can be produced. Determining the environmental conditions that regulate diapause termination may enable shortening diapause under laboratory conditions to increase production of adults to release. We tested three hibernating conditions (greenhouse [ambient temperature and photoperiod], glass door refrigerator [5 degrees C and ambient photoperiod], and growth chamber [5 degrees C and 24 h dark]) for three durations (4, 8, 11 wk). The highest proportion of females laying eggs came from the growth chamber, with 40% terminating diapause after 4 wk, 80% after 8 wk, and 95% after 11 wk of exposure. Our study demonstrates that duration of cold temperature is an important stimulus to terminate reproductive diapause of C. basicorne, and that exposure to ambient light had no effect at 5 degrees C. However, 47% of females held at ambient greenhouse conditions, without any chilling period, completed diapause within 11 wk. Thus, a cold period can accelerate diapause development, but it is not necessary for its completion. Reducing the winter diapause period from about 6 mo to 11 wk should enable the production of multiple generations per year to increase the number of insects available to release. | Smith, Lincoln; Park, Ikju | USDA ARS, Invas Species & Pollinator Hlth Res Unit, Western Reg Res Ctr, 800 Buchanan St, Albany, CA 94710 USA; Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea | 22977509400; 57200320797 | link.smith@usda.gov; | ENVIRONMENTAL ENTOMOLOGY | ENVIRON ENTOMOL | 0046-225X | 1938-2936 | 51 | 1 | SCIE | ENTOMOLOGY | 2022 | 1.7 | 39.5 | 0.45 | 2025-06-25 | 0 | 3 | diapause development; biocontrol; herbivore; hibernation | ANTHONOMUS-POMORUM COLEOPTERA; APPLE BLOSSOM WEEVIL; CENTAUREA-SOLSTITIALIS; HOST-SPECIFICITY; WEED MANAGEMENT; CALIFORNIA; CURCULIONIDAE; TEMPERATURE; PHOTOPERIOD; RELEASE | biocontrol; diapause development; herbivore; hibernation | Animals; Biological Control Agents; Coleoptera; Diapause; Diapause, Insect; Female; Photoperiod; Temperature; Weevils; beetle; biocontrol agent; biological control; diapause; environmental conditions; herbivore; hibernation; invasive species; perennial plant; photoperiod; rearing; reproduction; animal; beetle; biological control agent; diapause; female; photoperiodicity; physiology; temperature; weevil | English | 2022 | 2022-02-16 | 10.1093/ee/nvab110 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Inhibitory Effects of Euscaphic Acid in the Atopic Dermatitis Model by Reducing Skin Inflammation and Intense Pruritus | Atopic dermatitis (AD) is a complex and multifactorial skin disease characterized by skin inflammation and intense pruritus. There are many commercially available treatments such as topical corticosteroids and immunosuppressants to treat of AD, but their effectiveness is limited, and frequent use of these treatments can cause serious side effects. Therefore, the development of new therapeutic agents is necessary for the treatment of AD. Hence, an alternative agent that was derived from natural products that are effective and safe for AD treatment was investigated using experimental models. The biological activity of euscaphic acid has anti-inflammatory, anticoagulant, and antioxidant effects. Despite the various biomedical properties of euscaphic acid, its therapeutic effects on AD have not been well studied. In this study, we investigated the effects of euscaphic acid on skin inflammation and pruritus in AD mouse model. The effects of euscaphic acid were investigated in activated human epidermal keratinocytes and leukemia T lymphoblast cell lines, and Dermatophagoides farina extract and 2,4-dinitrochlorobenzene-induced AD mouse model. Euscaphic acid ameliorated AD properties, such as the expression of inflammatory cytokines and activation of transcription factors. In addition, euscaphic acid reduced critical factors for pruritus such as immunoglobulin E hyperproduction, mast cell invasion, and interleukin-33 expression. Taken together, euscaphic acid could be a potent therapeutic agent for the treatment of AD. | Jeong, Na-Hee; Lee, Soyoung; Choi, Young-Ae; Song, Kyung-Sik; Kim, Sang-Hyun | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Pharmacol, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup, South Korea; Kyungpook Natl Univ, Coll Pharm, GHAM BioPharm Co Ltd, Daegu, South Korea | ; Kim, Sang-Hyun/KQU-4555-2024 | 57194410234; 8537269200; 7404777420; 13310139000; 57210450420 | korryy@daum.net;kssong@knu.ac.kr;shkim72@knu.ac.kr; | INFLAMMATION | INFLAMMATION | 0360-3997 | 1573-2576 | 45 | 4 | SCIE | CELL BIOLOGY;IMMUNOLOGY | 2022 | 5.1 | 39.5 | 0.91 | 2025-06-25 | 9 | 11 | Atopic dermatitis; Euscaphic acid; Intense pruritus; Skin inflammation | MOLECULAR-COMPONENTS; SENSORY NEURONS; KERATINOCYTES; CELLS; IL-33; MECHANISMS; APOPTOSIS; RESPONSES; ITCH | Atopic dermatitis; Euscaphic acid; Intense pruritus; Skin inflammation | Animals; Cytokines; Dermatitis, Atopic; Dinitrochlorobenzene; Disease Models, Animal; Inflammation; Mice; Mice, Inbred BALB C; Pruritus; Skin; Triterpenes; 1 chloro 2,4 dinitrobenzene; gamma interferon; immunoglobulin E; immunoglobulin G2a; interleukin 1beta; interleukin 31; interleukin 33; interleukin 4; interleukin 6; tormentic acid; 1 chloro 2,4 dinitrobenzene; cytokine; tormentic acid; triterpene; adaptive immunity; animal cell; animal experiment; animal model; anticoagulation; antiinflammatory activity; antioxidant activity; Article; atopic dermatitis; celiac artery; controlled study; Dermatophagoides; enzyme linked immunosorbent assay; female; HaCat cell line; immunocytochemistry; keratinocyte; mouse; nonhuman; protein expression; pruritus; public health service; real time polymerase chain reaction; signal transduction; T lymphoblast; T lymphocyte; Th2 cell; Western blotting; animal; atopic dermatitis; Bagg albino mouse; disease model; inflammation; metabolism; pruritus; skin | English | 2022 | 2022-08 | 10.1007/s10753-022-01652-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Open-label, multi-center, phase II study of adjuvant pemetrexed plus cisplatin for completely resected stage IB to IIIA adenocarcinoma of the lung: APICAL trial | Background: We aimed to evaluate the efficacy of postoperative adjuvant pemetrexed plus cisplatin (Pem-Cis) in pathologic stage IB-IIIA lung adenocarcinoma (LUAD) patients. Methods: A prospective, phase II study was performed in seven institutions in South Korea. Patients with completely resected stage IB-IIIA LUAD received pemetrexed (500 mg/m(2)) plus cisplatin (75 mg/m(2)). Adjuvant treatments were administered every 3 weeks for 4 cycles. The primary endpoint was to prove the Pem-Cis's superiority in terms of 2-year disease-free survival rate (DFSR) compared with historical control without adjuvant chemotherapy (50%). Results: Between August 2015 and February 2018, 105 patients were enrolled in this study. Approximately 31.4% (n=33), 43.8% (n=46), and 24.8% (n=26) of patients had pathologic stage IB, II, and IIIA, respectively. Most of the patients underwent lobectomy (n=98, 93.3%). Moreover, 41.1% and 12.1% of the patients had epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase rearrangement. Four cycles of Pem-Cis were administered in 99 patients (94.3%). At a median follow-up of 57.7 months, the 2-year DFSR was 78.1%. Multivariable analysis showed that pathologic stage IIIA and EGFR mutation were significant risk factors for DFS. Grade 3 adverse events occurred in 10 patients (9.5%), and leukopenia (n=3, 2.9%) was the most common adverse event. Conclusions: Adjuvant Pem-Cis is superior to historical control without adjuvant treatment in terms of 2-year DFSR; the proportion of patients with stage IB and driver mutations were higher than that of patients in previous trials. Pem-Cis showed favorable tolerability as adjuvant chemotherapy. | Park, Cheol-Kyu; Oh, Hyung-Joo; Yoo, Seung Soo; Lee, Shin Yup; Lee, Sang Hoon; Kim, Eun Young; Lee, Sung Yong; Choi, Juwhan; Lee, Min Ki; Kim, Mi-Hyun; Jang, Tae Won; Chung, Chaeuk; Oh, In-Jae; Kim, Young-Chul | Chonnam Natl Univ, Med Sch, Dept Internal Med, Jeonnam, South Korea; Hwasun Hosp, Jeonnam, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Korea Univ, Dept Internal Med, Guro Hosp, Seoul, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Pusan, South Korea; Kosin Univ, Dept Internal Med, Gospel Hosp, Pusan, South Korea; Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon, South Korea; Chonnam Natl Univ Med Sch, Hwasun Hosp, Dept Internal Med, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea; Hwasun Hosp, 322 Seoyang Ro, Hwasun 58128, Jeonnam, South Korea | Lee, Sang-Hoon/ABH-6210-2020; Lee, Joo Yong/ADE-2110-2022; Kim, Woo/A-8216-2019; Oh, In-Jae/AAG-5919-2020; Park, Cheol-Kyu/AAT-9872-2021; Kim, Yong-Joo/AAK-1840-2021; Kim, Eun-Young/GQQ-0147-2022 | 57205721111; 57216363864; 56479781600; 49863712700; 57207065392; 57361264500; 56734650000; 57193228530; 16433227400; 26323727500; 7102426031; 14522036600; 58754601500; 35201246200 | kyc0923@jnu.ac.kr; | TRANSLATIONAL LUNG CANCER RESEARCH | TRANSL LUNG CANCER R | 2218-6751 | 2226-4477 | 11 | 8 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2022 | 4 | 39.6 | 0.3 | 2025-06-25 | 3 | 3 | Adjuvant chemotherapy; pemetrexed; cisplatin; non-small-cell carcinoma | CHEMOTHERAPY; VINORELBINE; CANCER; REFINEMENT | Adjuvant chemotherapy; cisplatin; non-small-cell carcinoma; pemetrexed | anaplastic lymphoma kinase; cisplatin; cyanocobalamin; epidermal growth factor receptor; folic acid; immune checkpoint inhibitor; pemetrexed; platinum derivative; protein tyrosine kinase inhibitor; abdominal pain; adjuvant chemotherapy; adult; aged; anorexia; Article; cancer patient; cancer staging; cancer surgery; colitis; comparative effectiveness; controlled study; coughing; disease free survival; drug safety; drug tolerability; fatigue; female; fever; follow up; gastrointestinal symptom; gene mutation; gene rearrangement; human; hypertransaminasemia; hyponatremia; infection; leukocyte count; leukocytosis; leukopenia; lobectomy; lung adenocarcinoma; lung embolism; major clinical study; male; multicenter study; multiple cycle treatment; nausea; open study; phase 2 clinical trial; pleura effusion; pneumonia; prospective study; risk factor; side effect; South Korea; vomiting | English | 2022 | 2022-08 | 10.21037/tlcr-22-183 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | PEGylated liposome encapsulating nido-carborane: boron neutron capture therapy (BNCT) and in vivo trafficking study in animal models | Kim, Kyungwon; Lee, Woonghee; Park, Hyun; Rajkumar, Subramani; Bhise, Abhinav; Lim, Jeong Eun; Kim, Jung Young; Lee, Kyo Chul; Yoo, Jeongsoo | Kyungpook Natl Univ, Daegu, South Korea; Korea Inst Radiol & Med Sci KIRAMS, Seoul, South Korea | Kim, Soon Hee/GXF-6736-2022; Bhise, Abhinav/MVY-6473-2025; Kim, Kyunghoon/AGO-0079-2022 | NUCLEAR MEDICINE AND BIOLOGY | NUCL MED BIOL | 0969-8051 | 1872-9614 | 108 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 3.1 | 39.6 | 0 | English | 2022 | 2022 (MAY-JUN) | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Prevalence and characteristics of vagus nerve variations on neck ultrasonography | Purpose: We aimed to evaluate the true prevalence and characteristics of vagus nerve (VN) variations using the carotid artery (CA) and the internal jugular vein (C-I axis). Methods: We examined patients who underwent neck ultrasonography ( US) conducted by a single operator. A VN variation was defined as a VN located anterior or medial to the C-I axis. The subtypes of VN variation were classified as anterolateral, anteromiddle, anteromedial, and medial based on the relative location of the VN to the CA. The primary outcome parameters were the prevalence of VN variations and differences according to side, age, and sex. Results: Out of 536 patients, right and left VN variations were identified in 20 (3.7%) and 186 (34.7%), respectively (P= 60 years was 23.8%, 22.5%, 34.4%, and 47.4%, respectively (P<0.001). Conclusion: Variations in the VN position were relatively common on US. The variations primarily involved the left VN in the lower cervical region, and an increasing prevalence with age was observed. | Ahn, Dongbin; Lee, Gil Joon; Sohn, Jin Ho; Kim, Jeong Kyu | Kyungpook Natl Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Catholic Univ Daegu, Sch Med, Dept Otolaryngol Head & Neck Surg, Daegu, South Korea | 44761055400; 57193082568; 55165818100; 57204123579 | godlikeu@naver.com; | ULTRASONOGRAPHY | ULTRASONOGRAPHY | 2288-5919 | 2288-5943 | 41 | 1 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 3.1 | 39.6 | 0.42 | 2025-06-25 | 2 | 3 | Neck; Vagus nerve; Variation; Ultrasonography; Prevalence | CAROTID-ENDARTERECTOMY; RISK-FACTORS; ABLATION; RADIOFREQUENCY; AGE | Neck; Prevalence; Ultrasonography; Vagus nerve; Variation | adult; article; carotid artery; controlled study; echography; female; human; internal jugular vein; major clinical study; male; neck; outcome assessment; patient right; prevalence; thyroid gland; vagus nerve | English | 2022 | 2022-01 | 10.14366/usg.21045 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Short PEG linkers considerably reduce background noise in immuno-PET tumor imaging | Nam, Bora; Lee, Woonghee; Park, Hyun; Bhise, Abhinav; Rajkumar, Subramani; Kim, Jung Young; Lee, Kiwoong; Cho, Seongwhan; Lim, Jeong Eun; Lee, Kyo Chul; Yoo, Jeongsoo | Kyungpook Natl Univ, Daegu, South Korea; Korea Inst Radiol & Med Sci KIRAMS, Seoul, South Korea | Bhise, Abhinav/MVY-6473-2025; Kim, Kyunghoon/AGO-0079-2022 | NUCLEAR MEDICINE AND BIOLOGY | NUCL MED BIOL | 0969-8051 | 1872-9614 | 108 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 3.1 | 39.6 | 0 | English | 2022 | 2022 (MAY-JUN) | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | The impact of systematic assessment for adverse events on unscheduled hospital utilization in patients receiving neoadjuvant or adjuvant chemotherapy: A retrospective multicenter study | Background This study was conducted to compare the reported adverse event (AE) profiles and unexpected use of medical services during chemotherapy between before and after the healthcare reimbursement of AE evaluation in patients with cancer. Patients and Methods Using the electronic medical record database system, extracted patients with breast, lung, gastric, and colorectal cancers receiving neoadjuvant or adjuvant chemotherapy between September 2013 and December 2016 at four centers in Korea were matched using the 1:1 greedy method: pre-reimbursement group (n = 1084) and post-reimbursement group (n = 1084). Unexpected outpatient department (OPD), emergency room (ER) visit, hospitalization rates, and chemotherapy completion rates were compared between the groups. Results The baseline characteristics were well-balanced between the groups. By chemotherapy cycle, hospitalization (1.8% vs. 2.3%; p = 0.039), and ER visit rates (3.3% vs. 3.9%; p = 0.064) were lower in the post-reimbursement group than that in the pre-reimbursement group. In particular, since cycle 2, ER visit and hospitalization rates were significantly lower in the post-reimbursement group than those in the pre-reimbursement group (2.6% vs. 3.3%; p = 0.020 and 1.4% vs. 2.0%; p = 0.007, respectively), although no significant differences were observed during cycle 1. The OPD visit rates were similar between both groups, regardless of cycles. The post-reimbursement group had a higher proportion of patients who completed chemotherapy as planned than the pre-reimbursement group (93.5% vs. 90.1%; p = 0.006). Post-reimbursement group had more AEs reported, including alopecia, fatigue, diarrhea, anorexia, and peripheral neuropathy, during cycle 1 than the pre-reimbursement group, which significantly decreased after cycle 2. Conclusion The introduction of healthcare reimbursement for AE evaluation may help physicians capture and appropriately manage AEs, consequently, decreasing hospital utilization and increasing chemotherapy completion rates. | Kim, Jwa Hoon; Seo, Seyoung; Kim, Jee Hyun; Koh, Su-Jin; Ahn, Yongchel; Jung, Kyung Hae; Ahn, Jin-Hee; Kim, Sung-Bae; Kim, Tae Won; Hong, Yong Sang; Kim, Sun Young; Kim, Jeong Eun; Kim, Sang-We; Lee, Dae Ho; Lee, Jae Cheol; Choi, Chang-Min; Yoon, Shinkyo; Jeong, Jae Ho; Kim, Hwa Jung; Suh, Koung Jin; Kim, Se Hyun; Kim, Yu Jung; Min, Young Joo; Baek, Jin Ho; Park, Sook Ryun | Univ Ulsan, Dept Oncol, Asan Med Ctr, Coll Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Korea Univ, Coll Med, Div Oncol, Dept Internal Med,Anam Hosp, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Ulsan Univ Hosp, Div Hematol & Oncol, Ulsan, South Korea; Univ Ulsan, Coll Med, Dept Hematol & Oncol, Gangneung Asan Hosp, Gangneung Si, South Korea; Univ Ulsan, Dept Clin Epidemiol & Biostat, Asan Med Ctr, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Oncol Hematol, Chilgok Hosp, Sch Med, Daegu, South Korea | Kim, Jwa/AAH-9915-2021; Park, Se Hoon/GMX-1199-2022; Kim, Tae-Hee/AAN-9079-2021; Kim, Sung/AAI-3081-2021; Ahn, Jin/C-6122-2019; Kim, Sung-Won/J-5409-2012; Kim, Sehyun/KDN-3343-2024; Kim, Tae Won/GRX-7323-2022; Kim, Pyeong Hwa/KGM-1468-2024 | 57189064876; 57194181893; 56004266300; 55286016300; 37661042100; 15765006000; 7403019217; 34770722200; 56504151300; 16041816900; 56579040100; 57218595065; 49061131600; 16401931900; 24825051600; 14024046800; 27068097600; 57022763500; 57049824100; 56035893600; 57041027400; 55694249900; 7202197178; 57217075847; 57197525194 | srpark@amc.seoul.kr; | CANCER MEDICINE | CANCER MED-US | 2045-7634 | 11 | 3 | SCIE | ONCOLOGY | 2022 | 4 | 39.6 | 0.11 | 2025-06-25 | 1 | 1 | adverse event; chemotherapy; emergency room visit; hospitalization | REPORTED OUTCOME MEASURES | adverse event; chemotherapy; emergency room visit; hospitalization | Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Hospitalization; Hospitals; Humans; Neoadjuvant Therapy; Retrospective Studies; alanine aminotransferase; antineoplastic agent; adjuvant chemotherapy; adolescent; adult; adverse event; aged; alopecia; anorexia; Article; breast cancer; cancer chemotherapy; colorectal cancer; constipation; controlled study; diarrhea; emergency ward; fatigue; female; hospital utilization; hospitalization; human; hyperbilirubinemia; Korea; lung cancer; major clinical study; male; middle aged; nausea; neoadjuvant chemotherapy; neutropenia; outpatient department; peripheral neuropathy; reimbursement; retrospective study; stomach cancer; stomatitis; thrombocytopenia; adjuvant chemotherapy; adverse event; clinical trial; hospital; hospitalization; multicenter study; neoadjuvant therapy | English | 2022 | 2022-02 | 10.1002/cam4.4476 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Unexpected hyperechoic lesions of the breast and their correlations with pathology: a pictorial essay | Hyperechoic lesions of the breast encompass a wide range of conditions that are occasionally encountered during breast ultrasonography. Although typical hyperechoic lesions with a distinct fat component on imaging are well known, some hyperechoic lesions are diagnosed as unexpected pathology, making the radiology-pathology correlation difficult. Therefore, understanding the pathology of these lesions and how it correlates with imaging findings can help radiologists accurately diagnose and properly manage a range of related conditions. This article presents a pictorial review of unexpected hyperechoic benign and malignant breast lesions, with a focus on the pathological conditions that give rise to the hyperechoic pattern. | Park, Seo Young; Park, Jee Young; Park, Ji Won; Kim, Won Hwa; Park, Ji Young; Kim, Hye Jung | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Radiol, 807 Hoguk Ro, Daegu 41404, South Korea; Fatima Hosp, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu, South Korea; Chamteunteun Hosp, Dept Radiol, Daegu, South Korea | Park, Jung Hwan/AAA-1951-2022 | 57210379391; 57226185359; 59282125800; 36081886500; 57210160197; 57203506201 | mamrad@knu.ac.kr; | ULTRASONOGRAPHY | ULTRASONOGRAPHY | 2288-5919 | 2288-5943 | 41 | 3 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 3.1 | 39.6 | 0.28 | 2025-06-25 | 3 | 2 | Breast ultrasonography; Breast neoplasm; Pathology | METASTASES; TUMORS | Breast neoplasm; Breast ultrasonography; Pathology | CD34 antigen; desmin; hemosiderin; uvomorulin; vimentin; abdominal pain; adult; Article; breast cancer; breast lesion; breast tissue; breast tumor; clinical article; echography; echomammography; female; fibroadenoma; fine needle aspiration biopsy; follow up; gynecomastia; hematologic malignancy; histopathology; human; human tissue; immunohistochemistry; invasive ductal carcinoma; lobular carcinoma; mastectomy; melanoma; microphotography; middle aged; needle biopsy; neoadjuvant chemotherapy; nuclear magnetic resonance imaging; pathology; phyllodes tumor; radiologist; T cell lymphoma; tissue Doppler imaging; vagina adenosis | English | 2022 | 2022-07 | 10.14366/usg.21243 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Correction | Carbon Monoxide Ameliorates 6-Hydroxydopa-mine-Induced Cell Death in C6 Glioma Cells (vol 26, pg 175, 2018) | Moon, Hyewon; Jang, Jung-Hee; Jang, Tae Chang; Park, Gyu Hwan | Kyungpook Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Daegu 41566, South Korea; Keimyung Univ, Sch Med, Dept Pharmacol, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Dept Emergency Med, Daegu 42472, South Korea | 57201156386; 7402965470; 57189297849; 9939639300 | emzzang@cu.ac.kr;park014@knu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 30 | 4 | SCIE | PHARMACOLOGY & PHARMACY | 2022 | 3.7 | 39.7 | 0 | 2025-06-25 | 0 | 0 | erratum | English | 2022 | 2022 | 10.4062/biomolther.2022.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling | Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist in human triple-negative breast cancer BT-20 and HCC-70 cells. Hydroxyzine inhibited the growth of cells in dose- and time-dependent manners. The annexin V/propidium iodide double staining assay showed that hydroxyzine induced apoptosis. The hydroxyzine-induced apoptosis was accompanied down-regulation of cyclins and CDKs, as well as the generation of reactive oxygen species (ROS) without cell cycle arrest. The effect of hydroxyzine on the induction of ROS and apoptosis on TNBC cells was prevented by pre-treatment with ROS scavengers, N-acetyl cysteine or Mito-TEMPO, a mitochondria-targeted antioxidant, indicating that an increase in the generation of ROS mediated the apoptosis induced by hydroxyzine. Western blot analysis showed that hydroxyzine-induced apoptosis was through down-regulation of the phosphorylation of JAK2 and STAT3 by hydroxyzine treatment. In addition, hydroxyzine induced the phosphorylation of JNK and p38 MAPK. Our results indicate that hydroxyzine induced apoptosis via mitochondrial superoxide generation and the suppression of JAK2/STAT3 signaling. | Shakya, Rajina; Park, Gyu Hwan; Joo, Sang Hoon; Shim, Jung-Hyun; Choi, Joon-Seok | Daegu Catholic Univ, Coll Pharm, Gyongsan 38430, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Mokpo Natl Univ, Coll Pharm, Muan 58554, South Korea | Joo, Sang/B-4116-2008 | 57195325875; 9939639300; 55550907200; 7201856171; 57203732561 | s1004jh@gmail.com;joonschoi@cu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 30 | 6 | SCIE | PHARMACOLOGY & PHARMACY | 2022 | 3.7 | 39.7 | 0.29 | 2025-06-25 | 4 | 3 | Hydroxyzine; Reactive oxygen species; Triple-negative breast cancer; JAK2/STAT3; Cell cycle; Apoptosis | APOPTOSIS; TRANSCRIPTION; INFLAMMATION; PATHWAY; STAT3 | Apoptosis; Cell cycle; Hydroxyzine; JAK2/STAT3; Reactive oxygen species; Triple-negative breast cancer | acetylcysteine; antioxidant; caspase 3; caspase 7; caspase 8; cyclin A; cyclin B; cyclin dependent kinase 1; cyclin dependent kinase 2; cyclin dependent kinase 4; cyclin E; cycline; hydroxyzine; Janus kinase 2; lipocortin 5; mitogen activated protein kinase p38; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein Bak; protein Bax; protein bcl 2; protein bcl xl; protein p16; protein p21; protein p27; reactive oxygen metabolite; STAT3 protein; superoxide; superoxide dismutase; apoptosis; apoptosis assay; Article; Bradford assay; BT-20 cell line; cancer cell; cell culture; cell cycle; cell cycle arrest; cell death; cell growth; cell proliferation; cell viability assay; chemoluminescence; colorimetry; cytotoxicity; down regulation; electrochemiluminescence; flow cytometry; fluorescence intensity; HCC70 cell line; human; human cell; IC50; mitochondrial membrane potential; mitochondrion; propidium iodide assay; protein phosphorylation; signal transduction; staining; triple negative breast cancer; Western blotting; WST assay | English | 2022 | 2022-11 | 10.4062/biomolther.2022.121 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Identification of Asbestos Slates in Buildings Based on Faster Region-Based Convolutional Neural Network (Faster R-CNN) and Drone-Based Aerial Imagery | Asbestos is a class 1 carcinogen, and it has become clear that it harms the human body. Its use has been banned in many countries, and now the investigation and removal of installed asbestos has become a very important social issue. Accordingly, many social costs are expected to occur, and an efficient asbestos investigation method is required. So far, the examination of asbestos slates was performed through visual inspection. With recent advances in deep learning technology, it is possible to distinguish objects by discovering patterns in numerous training data. In this study, we propose the use of drone images and a faster region-based convolutional neural network (Faster R-CNN) to identify asbestos slates in target sites. Furthermore, the locations of detected asbestos slates were estimated using orthoimages and compiled cadastral maps. A total of 91 asbestos slates were detected in the target sites, and 91 locations were estimated from a total of 45 addresses. To verify the estimated locations, an on-site survey was conducted, and the location estimation method obtained an accuracy of 98.9%. The study findings indicate that the proposed method could be a useful research method for identifying asbestos slate roofs. | Seo, Dong-Min; Woo, Hyun-Jung; Kim, Min-Seok; Hong, Won-Hwa; Kim, In-Ho; Baek, Seung-Chan | Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea; Kunsan Natl Univ, Dept Civil Engn, Gunsan 54150, South Korea; Kyungil Univ, Dept Architecture, Gyongsan 38428, South Korea | 57222555933; 57219244497; 59073001500; 7401527968; 58576577100; 56909374400 | dmseo@knu.ac.kr;woobi9107@knu.ac.kr;kms910601@knu.ac.kr;hongwh@knu.ac.kr;inho.kim@kunsan.ac.kr;baeksc@kiu.kr; | DRONES | DRONES-BASEL | 2504-446X | 6 | 8 | SCIE | REMOTE SENSING | 2022 | 4.8 | 39.7 | 1.69 | 2025-06-25 | 14 | 21 | aerial imagery; asbestos slate; drone; faster region-based convolutional neural network (Faster R-CNN) | EVENT | aerial imagery; asbestos slate; drone; faster region-based convolutional neural network (Faster R-CNN) | Aerial photography; Convolutional neural networks; Deep learning; Drones; Time difference of arrival; Aerial imagery; Asbestos slate; Class 1; Convolutional neural network; Fast region-based convolutional neural network; Human bodies; In-buildings; Region-based; Social issues; Target sites; Asbestos | English | 2022 | 2022-08 | 10.3390/drones6080194 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Protective Role of Corticosterone against Hydrogen Peroxide-Induced Neuronal Cell Death in SH-SY5Y Cells | Stress breaks body balance, which can cause diverse physiological disorders and worsen preexisting diseases. However, recent studies have reported that controllable stress and overcoming from stress reinforce resilience to resist against more intense stress afterwards. In this study, we investigated the protective effect of corticosterone (CORT), a representative stress hormone against hydrogen peroxide (H2O2)-induced neuronal cell death and its underlying molecular mechanism in SH-SY5Y cells, a human neuroblastoma cell line. The decreased cell viability by H2O2 was effectively restored by the pretreatment with low concentration of CORT (0.03 mu M for 72 h) in the cells. H2O2-increased expression of apoptotic markers such as PUMA and Bim was decreased by CORT pretreatment. Furthermore, pretreatment of CORT attenuated H2O2-mediated oxidative damages by upregulation of antioxidant enzymes via activation of nuclear factor erythroid 2-related factor 2 (Nrf2). These findings suggest that low concentration of CORT with eustressed condition enhances intracellular self-defense against H2O2-mediated oxidative cell death, suggesting a role of low concentration of CORT as one of key molecules for resilience and neuronal cell survival. | Lee, Chan; Jang, Jung-Hee; Park, Gyu Hwan | Keimyung Univ, Sch Med, Dept Pharmacol, Daegu 42601, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea | 55654791600; 7402965470; 9939639300 | pamy202@kmu.ac.kr;park014@knu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 30 | 6 | SCIE | PHARMACOLOGY & PHARMACY | 2022 | 3.7 | 39.7 | 0.2 | 2025-06-25 | 3 | 2 | Apoptosis; Eustress; Corticosterone; Nrf2; Antioxidant enzymes | OXIDATIVE STRESS; RESTRAINT STRESS; HIPPOCAMPUS; EXPRESSION; APOPTOSIS | Antioxidant enzymes; Apoptosis; Corticosterone; Eustress; Nrf2 | antioxidant; BIM protein; corticosterone; hydrogen peroxide; protein bcl 2; PUMA protein; reactive oxygen metabolite; stress hormone; transcription factor Nrf2; apoptosis; Article; cell death; cell survival; cell viability; enzyme linked immunosorbent assay; fluorescence intensity; human; lipid peroxidation; MTT assay; nerve cell; neuroblastoma; neurotoxicity; physiological stress; protein expression; SH-SY5Y cell line | English | 2022 | 2022-11 | 10.4062/biomolther.2022.126 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Selection of Take-Off and Landing Sites for Firefighter Drones in Urban Areas Using a GIS-Based Multi-Criteria Model | Currently, firefighter drones in Republic of Korea underperform due to the lack of take-off site reservations in advance. In order to address this issue, this study proposes a GIS-based multi-criteria model for selecting take-off and landing sites for firefighter drones in urban areas. Seven criteria were set for the selection of take-off and landing sites based on building roofs. Buildings at 318 sites in the target area that satisfy all seven criteria were extracted and grouped according to the geographical location. Among the grouped buildings, 11 sites were reselected through network analysis and central feature methods. In addition, two more sites were selected through the relaxation of criteria for take-off and landing sites for firefighter drones. Validation was performed using the data of building fires that occurred in the target area in the past. The results confirmed the effectiveness of the method applied in this study, as potential responses could be verified for >= 95% of the buildings with a past fire incidence. By introducing a simple methodology in which a multi-criteria model is built through spatial information, this study contributes to the literature on improving operational firefighting strategies and provides practitioners and policymakers with valuable insights to support decision-making. | Kim, Min-Seok; Hong, Won-Hwa; Lee, Yoon-Ha; Baek, Seung-Chan | Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea; Changshin Univ, Dept Fire & Disaster Prevent Engn, Chang Won 51352, South Korea; Kyungil Univ, Dept Architecture, Gyongsan 38428, South Korea | 59073001500; 7401527968; 57218699556; 56909374400 | yhlee@cs.ac.kr;baeksc@kiu.kr; | DRONES | DRONES-BASEL | 2504-446X | 6 | 12 | SCIE | REMOTE SENSING | 2022 | 4.8 | 39.7 | 0.4 | 2025-06-25 | 4 | 5 | firefighter drones; UAVs; GIS; Republic of Korea; urban areas; multi-criteria decision making | SYSTEM; LOCATION; DELIVERY | firefighter drones; GIS; multi-criteria decision making; Republic of Korea; UAVs; urban areas | Drones; Target drones; Firefighter drone; Landing site; Multi criteria decision-making; Multicriteria decision-making; Multicriteria modeling; Multicriterion decision makings; Off sites; Republic of Korea; Take off; Urban areas; Fire extinguishers | English | 2022 | 2022-12 | 10.3390/drones6120412 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Effect of Galangin on the Regulation of Vascular Contractility via the Holoenzyme Reactivation Suppressing ROCK/CPI-17 rather than PKC/CPI-17 | In this study, we investigated the influence of galangin on vascular contractibility and to determine the mechanism underlying the relaxation. Isometric contractions of denuded aortic muscles were recorded and combined with western blot analysis which was performed to measure the phosphorylation of phosphorylation-dependent inhibitory protein of myosin phosphatase (CPI-17) and myosin phosphatase targeting subunit 1 (MYPT1) and to evaluate the effect of galangin on the RhoA/ROCK/CPI-17 pathway. Galangin significantly inhibited phorbol ester-, fluoride-and thromboxane mimetic-induced vasoconstrictions regardless of endo-thelial nitric oxide synthesis, suggesting its direct effect on vascular smooth muscle. Galangin significantly inhibited the fluoride-dependent increase in pMYPT1 and pCPI-17 levels and phorbol 12,13-dibutyrate-dependent increase in pERK1/2 level, suggest-ing repression of ROCK and MEK activity and subsequent phosphorylation of MYPT1, CPI-17 and ERK1/2. Taken together, these results suggest that galangin-induced relaxation involves myosin phosphatase reactivation and calcium desensitization, which appears to be mediated by CPI-17 dephosphorylation via not PKC but ROCK inactivation. | Yoon, Hyuk-Jun; Jung, Won Pill; Min, Young Sil; Jin, Fanxue; Bang, Joon Seok; Sohn, Uy Dong; Je, Hyun Dong | Daegu Catholic Univ, Coll Pharm, Dept Pharmacol, Gyongsan 38430, South Korea; Jungwon Univ, Dept Pharmaceut Sci, Goesan 28024, South Korea; Kyungpook Natl Univ, Dept Pharmacol, Sch Med, Daegu 41944, South Korea; Sookmyung Womens Univ, Coll Pharm, Seoul 04310, South Korea; Chung Ang Univ, Coll Pharm, Dept Pharmacol, Seoul 06974, South Korea | 57201590819; 57487625100; 7202198543; 12788216300; 36855449200; 57188573852; 57221755247 | hyundong@cu.ac.kr; | BIOMOLECULES & THERAPEUTICS | BIOMOL THER | 1976-9148 | 2005-4483 | 30 | 2 | SCIE | PHARMACOLOGY & PHARMACY | 2022 | 3.7 | 39.7 | 0.2 | 2025-06-25 | 2 | 2 | CPI-17; Fluoride; Galangin; MYPT1; Phorbol ester; ROCK | LIGHT-CHAIN PHOSPHATASE; SMOOTH-MUSCLE; RHO-KINASE; CA2+ SENSITIZATION; TARGET SUBUNIT-1; MYOSIN; PHOSPHORYLATION; ACTIVATION; CPI-17; MYPT1 | CPI-17; Fluoride; Galangin; MYPT1; Phorbol ester; ROCK | 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid; acetone; acetylcholine; antioxidant; beta actin; bicarbonate; buffer; calcium; calcium chloride; carbon dioxide; dimethyl sulfoxide; dithiothreitol; endothelial nitric oxide synthase; etomidate; flavonol; fluoride; galangin; glucose; holoenzyme; horseradish peroxidase; immunoglobulin G; immunoglobulin M; magnesium chloride; mitogen activated protein kinase 1; mitogen activated protein kinase 3; myosin; myosin light chain; n(g) methylarginine; phenylephrine; phorbol dibutyrate; phorbol ester; potassium chloride; potassium dihydrogen phosphate; pyroxylin; RhoA guanine nucleotide binding protein; sodium chloride; thromboxane; trichloroacetic acid; vasoconstrictor agent; anesthesia; animal experiment; animal model; animal tissue; aortic media; Article; chemoluminescence; connective tissue; desensitization; exsanguination; immunoblotting; incubation time; male; nonhuman; polyacrylamide gel electrophoresis; protein expression; protein phosphorylation; rat; thoracic aorta; thoracotomy; vascular contractility; vascular smooth muscle; vasoconstriction; Western blotting | English | 2022 | 2022 | 10.4062/biomolther.2021.087 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Development of performance evaluation model for road and railway tunnels in use | Accurately evaluating and predicting the performance of facilities is a key task in establishing a maintenance strategy for facilities. The importance of performance evaluation is becoming more pronounced, especially when the aging of facilities requires a huge budget. In this study, performance assessment models were developed for road and railway tunnels. Delphi analysis was performed to identify sub-elements necessary to evaluate the performance of a tunnel. The relative importance of the evaluation factors was derived from the AHP analysis. The correlation analysis was performed between each assessment factor and the final result to verify the significance of the model. For the correlation analysis, the survey data measured through precision safety diagnosis in tunnels in use was applied. The cost effectiveness analysis was also conducted according to the scenarios with different composition of performance factors in order to improve the practical applicability of the evaluation model developed in this study. | Kim, Hong-Kyoon; Moon, Joon-Shik; An, Jai-Wook; Michael, E. S. | KALIS, Dept Ground Safety, Gyeongsangnamdo 52852, South Korea; Kyungpook Natl Univ, Dept Civil Engn, Daegu 41566, South Korea; DOT, State Maintenance Off, Tallahassee, FL 32399 USA | 57844351600; 57149572000; 56911649100; 57670634500 | j.moon@knu.ac.kr; | GEOMECHANICS AND ENGINEERING | GEOMECH ENG | 2005-307X | 2092-6219 | 29 | 3 | SCIE | ENGINEERING, CIVIL;ENGINEERING, GEOLOGICAL | 2022 | 3.2 | 39.9 | 0.36 | 2025-06-25 | 4 | 4 | AHP; evaluation; maintenance; performance; tunnel | AHP; evaluation; maintenance; performance; tunnel | Budget control; Correlation methods; Cost effectiveness; Factor analysis; Railroad transportation; Railroad tunnels; Railroads; Roads and streets; Correlation analysis; Evaluation; Evaluation factor; Maintenance strategies; Performance; Performance assessment models; Performance evaluation models; Performances evaluation; Road and railway tunnels; Sub-element; Hierarchical systems | English | 2022 | 2022-05-10 | 10.12989/gae.2022.29.3.369 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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