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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Withametelin, a novel phytosterol, alleviates neurological symptoms in EAE mouse model of multiple sclerosis via modulation of Nrf2/HO-1 and TLR4/NF-ΚB signaling | Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system (CNS) that remains incurable. Withametelin (WMT), a phytosterol, showed diverse biological activities isolated from the leaves of Datura innoxa. In the present study, we used an in vitro model of HT22 and BV-2 cell lines and an in vivo murine model of MS, experimental autoimmune encephalomyelitis (EAE), to explore the antioxidant and anti neuroinflammatory potential of WMT. The results showed that pretreatment with WMT markedly inhibited H2O2-induced cytotoxicity and oxidative stress in a dose-dependent manner. Correspondingly, WMT postimmunization treatment significantly attenuated EAE-induced clinical score, weight loss, neuropathic pain behaviors, and motor dysfunction. It markedly lowers EAE-induced elevated circulating leucocytes, spinal deformity, and splenomegaly. It strikingly inhibited the Evans blue and FITC extravasation in the brain. It remarkably reversed the EAE-induced histopathological alteration of the brain, spinal cord, eye, and optic nerve. It significantly intensified the antioxidant defense mechanism by improving the expression level of nuclear factorerythroid-related factor-2 (Nrf2), heme-oxygenase-1 (HO-1) but reducing the expression level of the Kelchlike-ECH-associated-protein-1 (keap-1), inducible-nitric-oxide-synthase (iNOS) in the CNS. Likewise, it markedly suppressed neuroinflammation by reducing the expression level of toll-like-receptor 4 (TLR4), nuclearfactor-kappa-B (NF-kappa B), activator-protein-1 (AP-1) but increased the expression level IkB-alpha in the CNS. Furthermore, molecular dynamics simulations and MMPBSA binding free energies were determined to validate the dynamic stability of complexes and shed light on the atomic level intermolecular interaction energies. Taken together, this study showed that WMT has significant neuroprotective potential in EAE via modulation of Nrf2 mediated-oxidative stress and NF-kappa B mediated inflammation. | Khan, Adnan; Shal, Bushra; Khan, Ashraf Ullah; Bibi, Tehmina; ul Islam, Salman; Baig, Muhammad Waleed; ul Haq, Ihsan; Ali, Hussain; Ahmad, Sajjad; Khan, Salman | Quaid I Azam Univ, Pharmacol Sci Res Lab, Dept Pharm, Fac Biol Sci, Islamabad, Pakistan; Kyungpook Natl Univ, Sch Life Sci, Coll Nat Sci, Daegu, South Korea; Quaid I Azam Univ, Dept Pharm, Fac Biol Sci, Islamabad, Pakistan; Abasyn Univ, Dept Hlth & Biol Sci, Peshawar 25000, Pakistan | khan, shahan/M-6985-2017; khan, sajid/HGE-2406-2022; Ahmad, Sajjad/ABG-7863-2020; Haq, Ihsan/A-6754-2015 | 57205082415; 57202263896; 57200756218; 57312741300; 56985186700; 57219124485; 55597767500; 56003879200; 57218961022; 54393307500 | adkhan165sbbu@gmail.com;bushra.shal@gmail.com;ashrafwazir6@gmail.com;tehmeenagul42@gmail.com;dr_ssulman@yahoo.com;mwbg7@yahoo.com;ihsn99@yahoo.com;h.ali@qau.edu.pk;sajjademaan8@gmail.com;udrsalman@gmail.com;skhan@qau.edu.pk; | NEUROCHEMISTRY INTERNATIONAL | NEUROCHEM INT | 0197-0186 | 1872-9754 | 151 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;NEUROSCIENCES | 2021 | 4.297 | 41.6 | 2.27 | 2025-07-30 | 38 | 37 | Multiple sclerosis; EAE; Withametelin; NF-kappa B; I kappa B-alpha; Nrf2; Keap-1; Cytokines | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; OXIDATIVE STRESS; NEUROINFLAMMATION; ACTIVATION; APOPTOSIS; CANCER; DAMAGE; BRAIN; PAIN; MICE | Cytokines; EAE; Multiple sclerosis; NF-κB/ IκB-α; Nrf2/Keap-1; Withametelin | Animals; Disaccharides; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Heme Oxygenase-1; Indoles; Mice; Neuroinflammatory Diseases; NF-E2-Related Factor 2; NF-kappa B; Phytosterols; Toll-Like Receptor 4; Evans blue; fluorescein isothiocyanate dextran; heme oxygenase 1; hydrogen peroxide; I kappa B kinase alpha; immunoglobulin enhancer binding protein; inducible nitric oxide synthase; kelch like ECH associated protein 1; methylprednisolone; neuroprotective agent; phytosterol; toll like receptor 4; transcription factor AP 1; transcription factor Nrf2; unclassified drug; withametelin; disaccharide; heme oxygenase 1; immunoglobulin enhancer binding protein; indole derivative; phytosterol; Tlr4 protein, mouse; toll like receptor 4; transcription factor Nrf2; withanamide A; animal behavior; animal cell; animal experiment; animal model; animal tissue; antioxidant activity; Article; body weight loss; brain; BV-2 cell line; cold allodynia; controlled study; cytotoxicity; drug mechanism; experimental autoimmune encephalomyelitis; extravasation; eye; female; histopathology; HT22 cell line; immunization; in vitro study; in vivo study; mechanical allodynia; molecular dynamics; motor dysfunction; motor performance; mouse; multiple sclerosis; muscle strength; nervous system inflammation; neuromodulation; neuropathic pain; neuroprotection; NF kB signaling; nonhuman; open field test; optic nerve; oxidative stress; protein expression; protein expression level; spinal cord; thermal hyperalgesia; TLR signaling; animal; disease model; drug effect; experimental autoimmune encephalomyelitis; metabolism | English | 2021 | 2021-12 | 10.1016/j.neuint.2021.105211 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Antibiofilm activity of silver nanoparticles against biofilm forming Staphylococcus pseudintermedius isolated from dogs with otitis externa | Background: Silver nanoparticles (AgNPs) are known to possess antimicrobial properties. Although the antibiofilm activity of AgNPs has been demonstrated in humans, this activity has not yet been elucidated in veterinary medicine. Objectives: The purpose of this study was to evaluate the antibiofilm activity of silver nanoparticles against Staphylococcus pseudintermedius. Methods: Ten isolates of S. pseudintermedius obtained from dogs with otitis externa were treated with AgNPs, and the antibiofilm activity was measured using a modified microtiter plate and Congo red agar (CRA) method and scanning electron microscopy. Results: AgNPs displayed a significant dose-dependent antibiofilm activity and reduced biofilm formation at concentrations of 20 and 10 mu g/ml (p < 0.05). S. pseudintermedius exposed to 20 mu g/ml of AgNPs formed less bacterial slime compared to the controls on CRA plates. Scanning electron micrographs showed that the biofilm had few individually scattered cells along its surface when treated with AgNP concentrations of 20 and 10 mu g/ml. Untreated surfaces showed an aggregated biofilm. Conclusions: Our results suggested that AgNP may be a valuable alternative antibiofilm agent for canine otitis externa. | Seo, Mimi; Oh, Taeho; Bae, Seulgi | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daegu 41566, South Korea | 57213829474; 8251199600; 55418865900 | sgbae@knu.ac.kr; | VETERINARY MEDICINE AND SCIENCE | VET MED SCI | 2053-1095 | 7 | 5 | SCIE | VETERINARY SCIENCES | 2021 | 1.776 | 41.7 | 3.33 | 2025-07-30 | 19 | 20 | antibiofilm; dog; otitis externa; silver nanoparticles; Staphylococcus pseudintermedius | ANTIBIOTICS; CELLS | antibiofilm; dog; otitis externa; silver nanoparticles; Staphylococcus pseudintermedius | Animals; Biofilms; Dog Diseases; Dogs; Metal Nanoparticles; Microbial Sensitivity Tests; Otitis Externa; Silver; Staphylococcus; agar; alcohol; phosphate buffered saline; RNA 16S; silver nanoparticle; metal nanoparticle; silver; alternative medicine; animal experiment; animal model; antibiofilm activity; antibiotic sensitivity; Article; biofilm; broth dilution; colony forming unit; controlled study; disk diffusion; dog; enzyme linked immunosorbent assay; external otitis; microtiter plate assay; minimum bactericidal concentration; nonhuman; RNA sequencing; scanning electron microscopy; Staphylococcus pseudintermedius; veterinary medicine; animal; biofilm; dog disease; external otitis; microbial sensitivity test; microbiology; Staphylococcus | English | 2021 | 2021-09 | 10.1002/vms3.554 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of intra-abdominal hypertension on the intraocular pressure of the conscious dogs | This study was performed to evaluate the effect of intra-abdominal pressure (IAP) on intraocular pressure (IOP) in conscious dog models using a balloon technique to generate intra-abdominal hypertension. Six healthy dogs without ocular abnormalities were evaluated in this study. A balloon device was placed in the intra-abdominal cavity. The abdomen was insufflated to IAP levels of 15 and 25 mmHg using the balloon device. Intraocular pressure was measured at baseline, at IAP levels of 15 and 25 mmHg, and after decompression. In comparison with the mean baseline IOP (15.1 +/- 2.0 mmHg), there was a significant increase in IOP at IAP levels of 15 mmHg (20.0 +/- 2.1 mmHg) and 25 mmHg (19.9 +/- 2.2 mmHg), corresponding to a 32.4% and 31.7% increase from baseline IOP, respectively. The mean IOP after decompression (14.8 +/- 1.7 mmHg) was significantly lower compared to those at IAP levels of 15 and 25 mmHg. The present findings demonstrate that increased IAP has a clinically significant effect on IOP in dogs under conscious conditions. Although more research is needed to determine of increased IAP on IOP, these findings suggest that increased IAP leads to mild and reversible increase in IOP. | Jang, Min; Son, Won-Gyun; Kim, Hyunseok; Won Shin, Chi; Lee, Inhyung | Seoul Natl Univ, Dept Vet Clin Sci, Coll Vet Med, 1 Gwanak Ro, Seoul 08826, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Surg, Daegu, South Korea | Kim, Hyunseok/NPI-8051-2025; Lee, Inhyung/AAG-5018-2020 | 55341507600; 35976781200; 57195296393; 57221762477; 7404441607 | inhyunglee@snu.ac.kr; | VETERINARY MEDICINE AND SCIENCE | VET MED SCI | 2053-1095 | 7 | 3 | SCIE | VETERINARY SCIENCES | 2021 | 1.776 | 41.7 | 0.19 | 2025-07-30 | 1 | 1 | dog; intra-abdominal hypertension; intra-abdominal pressure; intraocular pressure | CARDIOVASCULAR PARAMETERS; INTRACRANIAL-PRESSURE; COMPARTMENT SYNDROME; PROPOFOL; ANESTHESIA | dog; intra-abdominal hypertension; intra-abdominal pressure; intraocular pressure | Animals; Dog Diseases; Dogs; Intra-Abdominal Hypertension; Intraocular Pressure; Male; acepromazine; alfaxalone; carprofen; methadone; propofol; abdominal cavity; abdominal pressure; anesthesia induction; Article; breathing rate; central venous pressure; end tidal carbon dioxide tension; endoscopy; eye disease; eye malformation; glaucoma; heart rate; hypertension; hypotension; intraabdominal hypertension; intraocular pressure; laparoscopic surgery; laparoscopy; laparotomy; mean arterial pressure; nonhuman; ophthalmoscopy; pneumoperitoneum; pubis symphysis; systemic vascular resistance; animal; dog; dog disease; male; pathophysiology; veterinary medicine | English | 2021 | 2021-05 | 10.1002/vms3.441 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cogent and Energy Efficient Authentication Protocol for WSN in IoT | Given the accelerating development of Internet of things (IoT), a secure and robust authentication mechanism is urgently required as a critical architectural component. The IoT has improved the quality of everyday life for numerous people in many ways. Owing to the predominantly wireless nature of the IoT, connected devices are more vulnerable to security threats compared to wired networks. User authentication is thus of utmost importance in terms of security on the IoT. Several authentication protocols have been proposed in recent years, but most prior schemes do not provide sufficient security for these wireless networks. To overcome the limitations of previous schemes, we propose an efficient and lightweight authentication scheme called the Cogent Biometric-Based Authentication Scheme (COBBAS). The proposed scheme is based on biometric data, and uses lightweight operations to enhance the efficiency of the network in terms of time, storage, and battery consumption. A formal security analysis of COBBAS using Burrows?Abadi?Needham logic proves that the proposed protocol provides secure mutual authentication. Formal security verification using the Automated Validation of Internet Security Protocols and Applications tool shows that the proposed protocol is safe against man-in-the-middle and replay attacks. Informal security analysis further shows that COBBAS protects wireless sensor networks against several security attacks such as password guessing, impersonation, stolen verifier attacks, denial-of-service attacks, and errors in biometric recognition. This protocol also provides user anonymity, confidentiality, integrity, and biometric recovery in acceptable time with reasonable computational cost. | Butt, Tariq Mahmood; Riaz, Rabia; Chakraborty, Chinmay; Rizvi, Sanam Shahla; Paul, Anand | Univ Azad Jammu & Kashmir, Dept CS & IT, Muzaffarabad 13100, Pakistan; Birla Inst Technol, Mesra 814142, Jharkhand, India; Raptor Interact Pty Ltd, Eco Blvd,Witch Hazel Ave, ZA-0157 Centurion, South Africa; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | Paul, Anand/V-6724-2017; Riaz, Rabia/HJI-6429-2023; Chakraborty, Chinmay/N-3608-2017; Rizvi, Sanam Shahla/GQQ-8390-2022 | 57223113443; 24475180100; 7005340424; 25927493500; 56650522400 | paul.editor@gmail.com; | CMC-COMPUTERS MATERIALS & CONTINUA | CMC-COMPUT MATER CON | 1546-2218 | 1546-2226 | 68 | 2 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 3.86 | 41.8 | 1.17 | 2025-07-30 | 13 | 18 | Internet of things; wireless sensor networks; authentication; Burrows?Abadi?Needham logic; fuzzy extractor; elliptic curve cryptography | 2-FACTOR USER AUTHENTICATION; WIRELESS; SCHEME; SECURITY; PRIVACY | Authentication; Burrows-Abadi-Needham logic; Elliptic curve cryptography; Fuzzy extractor; Internet of things; Wireless sensor networks | Authentication; Biometrics; Computation theory; Cryptography; Denial-of-service attack; Digital storage; Energy efficiency; Internet of things; Internet protocols; Security systems; Wireless sensor networks; Architectural components; Authentication mechanisms; Authentication protocols; Biometric based authentication; Biometric recognition; Formal security analysis; Internet of Things (IOT); Stolen verifier attack; Network security | English | 2021 | 2021 | 10.32604/cmc.2021.014966 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Investigation of the optimal medium and application strategy for foot-and-mouth disease vaccine antigen production | Aims For the effective production of 146S particles, which determines foot-and-mouth disease (FMD) vaccine efficacy, we aimed to identify the optimal medium that is easy-to-use, productive and economically affordable for the large-scale production of FMD vaccine. Methods and Results Nine combinations of cell growth media and replacement media were tested for virus propagation. Apart from the replacement strategy, we tested a simple addition strategy involving the addition of 30% v/v of fresh medium to the total spent medium using the Cellvento BHK-200 (Vento). Unlike other tested media that produced poor yields of 146S particles when the spent media were not eliminated, Vento exhibited high productivity with the 30% addition strategy. Conclusions Considering its lower price and media consumption compared to those of other media that require media replacement, the 30% addition strategy of Vento is highly effective. Furthermore, owing to its simple application strategy, it makes the scale-up process easy and helps in saving the time and labour involved in spent media removal. Significance and Impact of the Study Through the first comparative assessment of commercial media for the 146S particle recovery, this study suggests the best practical medium for the industrial-scale production of FMD vaccines. | Kim, A. -Y.; Kim, H.; Park, S. Y.; Park, S. H.; Lee, J. -M.; Kim, J. -S.; Park, J. -W.; Park, C. -K.; Park, J. -H.; Ko, Y. -J. | Anim & Plant Quarantine Agcy, Gimcheon, Gyeonsangbuk Do, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Kyungpook Natl Univ, Anim Dis Intervent Ctr, Daegu, South Korea | Park, Sun/ABB-2937-2021 | 7402063210; 58369688700; 55616559900; 57219557904; 57196483573; 56106886000; 57191268769; 24768064900; 55717103700; 35068343300 | koyoungjoon@korea.kr; | JOURNAL OF APPLIED MICROBIOLOGY | J APPL MICROBIOL | 1364-5072 | 1365-2672 | 131 | 3 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MICROBIOLOGY | 2021 | 4.059 | 41.8 | 0.42 | 2025-07-30 | 5 | 5 | bioprocessing; diseases; vaccines; veterinary; viruses | HIGH-CELL-DENSITY; CULTURE PROCESS; VIRUS; CULTIVATIONS; QUANTIFICATION; BIOREACTORS; PERFUSION; PROTEIN; YIELDS; ATF | bioprocessing; diseases; vaccines; veterinary; viruses | Animals; Antigens, Viral; Culture Media; Foot-and-Mouth Disease; Foot-and-Mouth Disease Virus; Viral Vaccines; Cell proliferation; Diseases; Viruses; foot and mouth disease vaccine; virus antigen; virus vaccine; Application strategies; Bioprocessing; Foot and mouth disease; Growth medium; Large scale productions; Optimal applications; Optimal medium; Simple++; Vaccine efficacies; Veterinary; antigen; disease; vaccine; virus; Article; cell growth; Foot and mouth disease virus; large scale production; nonhuman; scale up; task performance; vaccine production; virus isolation; virus strain; animal; culture medium; foot and mouth disease; Vaccines | English | 2021 | 2021-09 | 10.1111/jam.15024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Medical image compression method using lightweight multi-layer perceptron for mobile healthcare applications | As video compression is one of the core technologies required to enable seamless medical data streaming in mobile healthcare applications, there is a need to develop powerful media codecs that can achieve minimum bitrates while maintaining high perceptual quality. Versatile Video Coding (VVC) is the latest video coding standard that can provide powerful coding performance with a similar visual quality compared to the previously developed method that is High Efficiency Video Coding (HEVC). In order to achieve this improved coding performance, VVC adopted various advanced coding tools, such as flexible Multi-type Tree (MTT) block structure which uses Binary Tree (BT) split and Ternary Tree (TT) split. However, VVC encoder requires heavy computational complexity due to the excessive Rate-distortion Optimization (RDO) processes used to determine the optimal MTT block mode. In this paper, we propose a fast MTT decision method with two Lightweight Neural Networks (LNNs) using Multi-layer Perceptron (MLP), which are applied to determine the early termination of the TT split within the encoding process. Experimental results show that the proposed method significantly reduced the encoding complexity up to 26% with unnoticeable coding loss compared to the VVC Test Model (VTM). © 2021 Tech Science Press. All rights reserved. | Lee, Taesik; Jun, Dongsan; Park, Sang-Hyo; Kim, Byung-Gyu; Yun, Jungil; Yun, Kugjin; Cheong, Won-Sik | Kyungnam University, Changwon, 51767, South Korea; Kyungnam University, Changwon, 51767, South Korea; Kyungpook National University, Daegu, 41566, South Korea; Sookmyung Women's University, Seoul, 04310, South Korea; Electronics and Telecommunications Research Institute, Daejeon, 34129, South Korea; Electronics and Telecommunications Research Institute, Daejeon, 34129, South Korea; Electronics and Telecommunications Research Institute, Daejeon, 34129, South Korea | 57251485100; 36061894700; 55362514700; 7501567302; 7201754045; 7102171351; 27171265600 | dsjun9643@kyungnam.ac.kr; | Computers, Materials and Continua | CMC-COMPUT MATER CON | 1546-2218 | 1546-2226 | 70 | 1 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 3.86 | 41.8 | 0 | 2025-07-30 | 1 | Complexity reduction; Intra prediction; Mobile healthcare; Multi-type tree; Multilayer perceptron; Neural network; Ternary tree; Video coding; VVC | Binary trees; Complex networks; Electric distortion; Encoding (symbols); Health care; Image coding; Image compression; Media streaming; Medical image processing; Signal distortion; Signal encoding; Video signal processing; Coding performance; Encoding complexity; Health care application; High-efficiency video coding; Multi layer perceptron; Perceptual quality; Rate-distortion optimization; Video coding standard; Multilayer neural networks | English | Final | 2021 | 10.32604/cmc.2022.019604 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Multi-Modal Data Analysis Based Game Player Experience Modeling Using LSTM-DNN | Game player modeling is a paradigm of computational models to exploit players' behavior and experience using game and player analytics. Player modeling refers to descriptions of players based on frameworks of data derived from the interaction of a player's behavior within the game as well as the player's experience with the game. Player behavior focuses on dynamic and static information gathered at the time of gameplay. Player experience concerns the association of the human player during gameplay, which is based on cognitive and affective physiological measurements collected from sensors mounted on the player's body or in the player's surroundings. In this paper, player experience modeling is studied based on the board puzzle game "Candy Crush Saga" using cognitive data of players accessed by physiological and peripheral devices. Long Short-Term Memory-based Deep Neural Network (LSTM-DNN) is used to predict players' effective states in terms of valence, arousal, dominance, and liking by employing the concept of transfer learning. Transfer learning focuses on gaining knowledge while solving one problem and using the same knowledge to solve different but related problems. The homogeneous transfer learning approach has not been implemented in the game domain before, and this novel study opens a new research area for the game industry where the main challenge is predicting the significance of innovative games for entertainment and players' engagement. Relevant not only from a player's point of view, it is also a benchmark study for game developers who have been facing problems of "cold start" for innovative games that strengthen the game industrial economy. | Farooq, Sehar Shahzad; Fiaz, Mustansar; Mehmood, Irfan; Bashir, Ali Kashif; Nawaz, Raheel; Kim, KyungJoong; Jung, Soon Ki | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea; Univ Bradford, Sch Media Design & Technol, Fac Engn & Informat, Bradford BD7 1DP, W Yorkshire, England; Manchester Metropolitan Univ, Dept Comp & Math, Manchester, Lancs, England; Manchester Metropolitan Univ, Dept Operat Technol Events & Hospitality Manageme, Manchester, Lancs, England; Gwangju Inst Sci & Technol, Inst Integrated Technol, Gwangju, South Korea | Nawaz, Raheel/AAX-5293-2021; Jung, Soon Ki/P-7687-2018; Bashir, Ali Kashif/R-4015-2019 | 57217701362; 57208735843; 36628922400; 57193954653; 52164201600; 57211238989; 57226791905 | skjung@knu.ac.kr; | CMC-COMPUTERS MATERIALS & CONTINUA | CMC-COMPUT MATER CON | 1546-2218 | 1546-2226 | 68 | 3 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 3.86 | 41.8 | 0.14 | 2025-07-30 | 2 | 3 | Game player modeling; experience modeling; player analytics; deep learning; LSTM; game play data; Candy Crush Saga | Candy Crush Saga; Deep learning; Experience modeling; Game play data; Game player modeling; LSTM; Player analytics | Deep learning; Deep neural networks; Entertainment industry; Modal analysis; Psychophysiology; Transfer learning; User experience; Benchmark study; Computational model; Multi-modal data; Peripheral devices; Physiological measurement; Player experience; Player experience modeling; Static information; Long short-term memory | English | 2021 | 2021 | 10.32604/cmc.2021.015612 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Multi-Span and Multiple Relevant Time Series Prediction Based on Neighborhood Rough Set | Rough set theory has been widely researched for time series prediction problems such as rainfall runoff. Accurate forecasting of rainfall runoff is a long standing but still mostly significant problem for water resource planning and management, reservoir and river regulation. Most research is focused on constructing the better model for improving prediction accuracy. In this paper, a rainfall runoff forecast model based on the variable-precision fuzzy neighborhood rough set (VPFNRS) is constructed to predict Watershed runoff value. Fuzzy neighborhood rough set define the fuzzy decision of a sample by using the concept of fuzzy neighborhood. The fuzzy neighborhood rough set model with variable-precision can reduce the redundant attributes, and the essential equivalent data can improve the predictive capabilities of model. Meanwhile VFPFNRS can handle the numerical data, while it also deals well with the noise data. In the discussed approach, VPFNRS is used to reduce superfiuous attributes of the original data, the compact data are employed for predicting the rainfall runoff. The proposed method is examined utilizing data in the Luo River Basin located in Guangdong, China. The prediction accuracy is compared with that of support vector machines and long short ter m memory (LSTM). The experiments show that the method put forward achieves a higher predictive performance. | Li, Xiaoli; Zhou, Shuailing; An, Zixu; Du, Zhenlong | Nanjing Tech Univ, Sch Comp Sci & Technol, Nanjing 211816, Peoples R China; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | Li, Xiaoli/GYQ-7384-2022 | 56464846100; 57219710468; 57222356503; 13006766700 | anzixu@knu.ac.kr; | CMC-COMPUTERS MATERIALS & CONTINUA | CMC-COMPUT MATER CON | 1546-2218 | 1546-2226 | 67 | 3 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 3.86 | 41.8 | 0.14 | 2025-07-30 | 3 | 2 | Rainfall and runoff; variable precision fuzzy neighborhood rough set; LSTM; multi-span | ARTIFICIAL NEURAL-NETWORK; MACHINE | LSTM; Multi-span; Rainfall and runoff; Variable precision fuzzy neighborhood rough set | Forecasting; Long short-term memory; Predictive analytics; Rain; Reservoir management; Reservoirs (water); Runoff; Support vector machines; Time series; Neighborhood rough sets; Prediction accuracy; Predictive capabilities; Predictive performance; Rainfall-runoff forecast; Time series prediction; Variable precision; Water resource planning; Rough set theory | English | 2021 | 2021 | 10.32604/cmc.2021.012422 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | 4-Hexylresorcinol Inhibits Class I Histone Deacetylases in Human Umbilical Cord Endothelial Cells | Featured Application Histone deacetylase inhibitor has broad spectrum therapeutic merits. This study demonstrated that 4-hexylresorcinol was a novel histone deacetylase inhibitor. Histone deacetylases (HDACs) are key enzymes for post-translational modification and influence on various cellular activities. Thus, HDACs are associated with many diseases and their inhibitors have clinical significance. Here, 4-Hexylresorcinol (4HR) was studied as an inhibitor for class I HDACs using the HDAC inhibitor (HDACi) Trichostatin-A as a positive control. The 4HR was administered 1-100 mu M to human umbilical endothelial cells (HUVECs) and the HDAC expression and activity were examined. The 4HR decreased the expression level of HDAC1, 3, 4, and 5 in a time and dose-dependent manner. The 4HR also increased acetylated lysine and decreased HDAC activity significantly (p < 0.05). Collectively, 4HR was a new class I HDAC inhibitor that reduced the expression and activity of HDAC in HUVECs. | Kim, Jwa-Young; Kweon, Hae-Yong; Kim, Dae-Won; Choi, Je-Yong; Kim, Seong-Gon | Hallym Univ, Med Ctr, Dept Dent Oral & Maxillofacial Surg, Kangnam Sacred Heart Hosp, 1 Singil Ro, Seoul 07441, South Korea; Rural Dev Adm, Natl Inst Agr Sci, Sericultural & Apicultural Div, Wonju 55365, South Korea; Gangneung Wonju Natl Univ, Dept Biochem & Mol Biol, Coll Dent, Kangnung 28644, South Korea; Kyungpook Natl Univ, Skeletal Dis Anal Ctr, Korea Mouse Phenotyping Ctr, Dept Biochem & Cell Biol,Cell & Matrix Res Inst,S, Daegu 41944, South Korea; Gangneung Wonju Natl Univ, Dept Oral & Maxillofacial Surg, Coll Dent, Kangnung 28644, South Korea | Choi, Je-Yong/AAR-7334-2021; Kim, Seong-Gon/AAF-7553-2020 | 35368445600; 7004390708; 56194913400; 7501391068; 27171913700 | jwayoung@hanmail.net;hykweon@korea.kr;kimdw@gwnu.ac.kr;jechoi@knu.ac.kr;kimsg@gwnu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 8 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 0.89 | 2025-07-30 | 11 | 12 | 4-hexylresorcinol; histone deacetylase; mitochondria; ATP | 4-hexylresorcinol; ATP; Histone deacetylase; Mitochondria | English | 2021 | 2021-04 | 10.3390/app11083486 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A Corner-Highlighting Method for Ambient Occlusion | Graphical user experiences are now ubiquitous features, and therefore widespread. Specifically, the computer graphics field and the game industry have been continually favoring the ambient occlusion post-processing method for its superb indirect light approximation and its effectiveness. Nonetheless of its canonical performance, its operation on non-occluded surfaces is often seen redundant and unfavorable. In this paper, we propose a new perspective to handle such issues by highlighting the corners where ambient occlusion is likely to occur. Potential illumination occlusions are highlighted by checking the corners of the surfaces in the screen-space. Our algorithm showed feasibility for renderers to avoid unwanted computations by achieving performance improvements of 15% to 28% acceleration, in comparison to the previous works. | Park, Sukjun; Baek, Nakhoon | KOG Inc, Daegu 41937, South Korea; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Data Convergence Comp, Daegu 41566, South Korea; Dassomey Com Inc, Daegu 41566, South Korea | 57212930681; 7007017954 | pos02232@gmail.com;oceancru@gmail.com; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 7 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 0.07 | 2025-07-30 | 1 | 1 | ambient occlusion; screen space; corner highlighting | Ambient occlusion; Corner highlighting; Screen space | English | 2021 | 2021-04 | 10.3390/app11073276 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | A Facile HPLC-UV-Based Method for Determining the Concentration of the Bacterial Universal Signal Autoinducer-2 in Environmental Samples | As a universal quorum sensing (QS) signal, autoinducer-2 (AI-2) is utilized by both Gram-negative and Gram-positive bacteria to coordinate several group behaviors, such as biofilm formation, virulence, and motility, when the bacterial cell density exceeds the thresholds. The determination of the AI-2 level is essential to understand the physiological and biochemical processes involved in bacterial communication. However, the current methods for AI-2 determination are complicated, time-consuming, and require costly equipment, such as a mass spectrometer (MS) or fluorescence detector (FLD). In this study, we present a new and easily applicable method for AI-2 determination. This method, based on the primary derivatization of AI-2 with 2,3-diaminonaphthalene (DAN), uses an affordable high-performance liquid chromatography (HPLC) instrument with a UV detector. Under optimized conditions, our method showed a good linearity (r(2) = 0.999) and demonstrated the effective detection of AI-2 levels in various environmental samples, as follows: 0.38 (+/- 0.05) mu M for E. coli K12, 0.48 (+/- 0.05) mu M for Aeromonas sp. YB-2, 0.32 (+/- 0.06) mu M for the Enterobacter sp. YB-3, and 0.28 (+/- 0.16) mu M for activated sludge. | Lee, Kibaek; Lee, Chung-Hak; Choo, Kwang-Ho | Chonnam Natl Univ, Dept Biotechnol & Bioengn, Gwangju 61186, South Korea; Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 08826, South Korea; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Adv Inst Water Ind, Daegu 41566, South Korea | Choo, Kwang-Ho/A-3456-2016; 이, 정학/GWQ-6252-2022 | 55845961700; 7410142508; 7102083272 | kibaek@jnu.ac.kr;leech@snu.ac.kr;chookh@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 19 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 0.37 | 2025-07-30 | 7 | 7 | autoinducer-2; (S)-4,5-dihydroxy-2,3-pentandione; HPLC-UV; quorum sensing; activated sludge | QUORUM-SENSING SIGNAL; PERFORMANCE LIQUID-CHROMATOGRAPHY; CELL COMMUNICATION; BIOFOULING CONTROL; QUANTIFICATION | (S)-4; 3-pentandione; 5-dihydroxy-2; Activated sludge; Autoinducer-2; HPLC-UV; Quorum sensing | English | 2021 | 2021-10 | 10.3390/app11199116 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A Hybrid Approach Combining R*-Tree and k-d Trees to Improve Linked Open Data Query Performance | Semantic Web has recently gained traction with the use of Linked Open Data (LOD) on the Web. Although numerous state-of-the-art methodologies, standards, and technologies are applicable to the LOD cloud, many issues persist. Because the LOD cloud is based on graph-based resource description framework (RDF) triples and the SPARQL query language, we cannot directly adopt traditional techniques employed for database management systems or distributed computing systems. This paper addresses how the LOD cloud can be efficiently organized, retrieved, and evaluated. We propose a novel hybrid approach that combines the index and live exploration approaches for improved LOD join query performance. Using a two-step index structure combining a disk-based 3D R*-tree with the extended multidimensional histogram and flash memory-based k-d trees, we can efficiently discover interlinked data distributed across multiple resources. Because this method rapidly prunes numerous false hits, the performance of join query processing is remarkably improved. We also propose a hot-cold segment identification algorithm to identify regions of high interest. The proposed method is compared with existing popular methods on real RDF datasets. Results indicate that our method outperforms the existing methods because it can quickly obtain target results by reducing unnecessary data scanning and reduce the amount of main memory required to load filtering results. | Sun, Yuxiang; Zhao, Tianyi; Yoon, Seulgi; Lee, Yongju | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | 57202927837; 57222509116; 57222511188; 57207015176 | syx921120@gmail.com;zty950731@gmail.com;tmffml123@naver.com;yongju@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 5 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 0.37 | 2025-07-30 | 5 | 5 | LOD cloud; Big Data; multidimensional histogram; index structure; join query; RDF | Big Data; Index structure; Join query; LOD cloud; Multidimensional histogram; RDF | English | 2021 | 2021-03 | 10.3390/app11052405 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | A Novel Method for Precise Guided Hole Fabrication of Dental Implant Surgical Guide Fabricated with 3D Printing Technology | A dental implant surgical guide fabricated by 3-dimensional (3D) printing technology is widely used in clinical practice due to its convenience and fast fabrication. However, the 3D printing technology produces an incorrect guide hole due to the shrinkage of the resin materials, and in order to solve this, the guide hole is adjusted using a trimmer or a metal sleeve is attached to the guide hole. These methods can lead to another inaccuracy. The present method reports a technique to compensate for a decreased guide hole caused by shrinkage that can occur when a computer-guided implant surgical guide is fabricated with a 3D printer. The present report describes a technique to adjust the size of the guide hole using a free software program to identify the optimized guide hole size that is fabricated with the 3D printer. | Son, Keunbada; Lee, Kyu-bok | Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, Daegu 41940, South Korea; Kyungpook Natl Univ, Adv Dent Device Dev Inst, Daegu 41940, South Korea; Kyungpook Natl Univ, Dept Prosthodont, Sch Dent, Daegu 41940, South Korea | Son, Keunbada/AAG-8089-2019; SON, Keunbada/AAG-8089-2019 | 57202916520; 15925571200 | sonkeunbada@gmail.com;kblee@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 1 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 0.74 | 2025-07-30 | 11 | 10 | surgical guide; 3D printing; guided hole; dental CAD; CAM; dental implant | TOLERANCE; SURGERY; ACCURACY | 3D printing; Dental CAD/CAM; Dental implant; Guided hole; Surgical guide | English | 2021 | 2021-01 | 10.3390/app11010049 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A Risk Assessment for Ozone Regulation Based on Statistical Rollback | In environmental studies, it is important to assess how regulatory standards for air pollutants affect public health. High ozone levels contribute to harmful air pollutants. The EPA regulates ozone levels by setting ozone standards to protect public health. It is thus crucial to assess how various regulatory ozone standards affect non-accidental mortality related to respiratory deaths during the ozone season. The original rollback approach provides an adjusted ozone process under a new regulation scenario in a deterministic fashion. Herein, we consider a statistical rollback approach to allow for uncertainty in the rollback procedure by adopting the quantile matching method so that it provides flexible rollback sets. Hierarchical Bayesian models are used to predict the potential effects of different ozone standards on human health. We apply the method to epidemiologic data. | Kim, Yongku; Lee, Jeongjin | Kyungpook Natl Univ, Dept Stat, Daegu 41566, South Korea; Colorado State Univ, Dept Stat, Ft Collins, CO 80523 USA | 47962102500; 57217214205 | kim.1252@knu.ac.kr;stecophil88@gmail.com; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 5 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 0 | 2025-07-30 | 0 | 0 | hierarchical model; mortality; ozone regulatory standard; risk assessment; stochastic rollback | HEALTH-BENEFITS; POLLUTION; MORTALITY | Hierarchical model; Mortality; Ozone regulatory standard; Risk assessment; Stochastic rollback | English | 2021 | 2021-03 | 10.3390/app11052388 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A Secure Key Aggregate Searchable Encryption with Multi Delegation in Cloud Data Sharing Service | As the amount of data generated in various distributed environments is rapidly increasing, cloud servers and computing technologies are attracting considerable attention. However, the cloud server has privacy issues, including personal information and requires the help of a Trusted Third Party (TTP) for data sharing. However, because the amount of data generated and value increases, the data owner who produces data must become the subject of data sharing. In this study, we use key aggregate searchable encryption (KASE) technology, which enables keyword search, to efficiently share data without using TTP. The traditional KASE scheme approach only discusses delegation of authority from the data owner to another user. However, if the delegated entity cannot perform time-critical tasks because the shared data are unavailable, the delegate must further delegate the rights given to other users. Consequently, this paper proposes a new KASE scheme that enables multi-delegation without TTP and includes an authentication technique between the user and the server. After that, we perform informal and formal analysis using BAN logic and AVISPA for security evaluation, and compare the security and performance aspects with existing schemes. | Lee, JoonYoung; Kim, MyeongHyun; Oh, JiHyeon; Park, YoungHo; Park, KiSung; Noh, Sungkee | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Elect & Telecommun Res Inst, Blockchain Technol Res Ctr, Daejeon 34129, South Korea | Lee, JoonYoung/AAM-9838-2021; Park, Kisung/KIG-3849-2024 | 57203970123; 57210278739; 57222066296; 56962990300; 57194833768; 56207592700 | parkyh@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 11 | 19 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 2.838 | 41.9 | 0.59 | 2025-07-30 | 11 | 12 | KASE; cloud server; data sharing; delegation; BAN logic; AVISPA; MIRACL | AUTHENTICATION PROTOCOL; MANAGEMENT PROTOCOL; INTERNET; DESIGN; IOV | AVISPA; BAN logic; Cloud server; Data sharing; Delegation; KASE; MIRACL | English | 2021 | 2021-10 | 10.3390/app11198841 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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