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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | National Survey Regarding the Management of Difficult Bile Duct Stones in South Korea | Background/Aims: This study aimed to investigate the patterns of preferred endoscopic proce-dure types and techniques for managing difficult common bile duct (CBD) stones in South Korea. Methods: The Committee of Policy and Quality Management of Korean Pancreatobiliary Asso-ciation (KPBA) conducted a survey containing 19 questions. Both paper and online surveys were carried out; with the paper survey being conducted during the 2019 Annual Congress of KPBA and the online survey being conducted through Google Forms from April 2020 to February 2021. Results: The response rate was approximately 41.3% (86/208). Sixty-two (73.0%) worked at tertiary hospitals or academic medical centers, and 60 (69.7%) had more than 5 years of en-doscopic retrograde cholangiopancreatography experience. The preferred size criteria for large CBD stones were 15 mm (40.6%), 20 mm (31.3%), and 30 mm (4.6%). For managing of large CBD stones, endoscopic papillary large balloon dilation after endoscopic sphincterotomy was the most preferred technique (74.4%). When performing procedures in those with bleeding diathesis, 64 (74.4%) respondents favored endoscopic papillary balloon dilation (EPBD) alone or EPBD with small endoscopic sphincterotomy. Fifty-five respondents (63.9%) preferred the double-guidewire technique when faced with difficult bile duct cannulation in patients with periampullary diverticulum. In surgically altered anatomies, cap-fitted forward viewing endoscopy (76.7%) and percutaneous transhepatic cholangioscopy (48.8%) were the preferred techniques for Billroth-II anastomosis and total gastrectomy with Roux-en-Y anastomosis, respectively. Conclusions: Most respondents showed unifying trends for the management of difficult CBD stones. The current practice patterns could be used as basic data for clinical quality improve-ments in the management of difficult CBD stones. (Gut Liver, Published online July 19, 2022) | Lee, Yoon Suk; Jeon, Tae Joo; Paik, Woo Hyun; Ahn, Dong-Won; Chung, Kwang Hyun; Son, Byoung Kwan; Song, Tae Jun; Moon, Sung-Hoon; Lee, Eaum Seok; Lee, Jae Min; Yoon, Seung Bae; Paik, Chang Nyol; Lee, Yun Nah; Park, Jin-Seok; Lee, Dong Wook; Park, Sang Wook; Chon, Hyung Ku; Cho, Kwang Bum; Park, Chang Hwan | Inje Univ, Ilsan Paik Hosp, Dept Internal Med, Coll Med, Goyang, South Korea; Inje Univ, Sanggye Paik Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Seoul Metropolitan Govt, Dept Internal Med, Boramae Med Ctr,Coll Med, Seoul, South Korea; Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Internal Med, Sch Med, Uijongbu, South Korea; Univ Ulsan, Asan Med Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Coll Med, Anyang, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Internal Med, Coll Med, Daejeon, South Korea; Korea Univ, Anam Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Eunpyeong St Marys Hosp, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, St Vincents Hosp, Suwon, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Coll Med, Bucheon, South Korea; Inha Univ, Dept Internal Med, Sch Med, Incheon, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kwangju Christian Hosp, Dept Internal Med, Gwangju, South Korea; Wonkwang Univ, Wonkwang Univ Hosp, Dept Internal Med, Sch Med, Iksan, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Internal Med, Sch Med, Daegu, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Internal Med, Med Sch, Gwangju, South Korea | Song, Taejun/JVZ-2733-2024; Paik, Woo Hyun/B-9003-2016; Paik, Woo/B-9003-2016; Chon, Hyung ku/AGO-1334-2022; Lee, Yoon Suk/D-1827-2019; LEE, Yoon-Suk/D-1827-2019; Lee, Yun/J-1260-2014 | 57219432560; 57217483767; 35822559900; 14022272100; 57217552216; 7007055567; 26028951400; 34870386900; 41461392000; 8636426500; 35217323900; 15058072500; 57129189700; 16241892100; 57202974895; 56864689800; 57191108189; 7403956834; 57207441931 | p1052ccy@hanmail.net; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 17 | 3 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 3.4 | 30.4 | 0.29 | 2025-06-25 | 1 | 2 | Key Words; Bile ducts; Gallstones; Endoscopy; Cholangiopancreatography endoscopic retro-grade; Surveys and questionnaires | ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; CHOLEDOCHOLITHIASIS; SPHINCTEROTOMY | Bile ducts; Cholangiopancreatography endoscopic retrograde; Endoscopy; Gallstones; questionnaires; Surveys | Cholangiopancreatography, Endoscopic Retrograde; Gallstones; Humans; Republic of Korea; Sphincterotomy, Endoscopic; Treatment Outcome; adult; Article; balloon dilatation; bile duct stone; biliary cannulation; bleeding tendency; clinical practice; controlled study; digestive tract endoscopy; duodenum diverticulum; endoscopic retrograde cholangiopancreatography; endoscopic sphincterotomy; endoscopic surgery; endoscopist; female; gastrectomy Billroth II; health survey; human; major clinical study; male; middle aged; online system; patient care; percutaneous transhepatic cholangioscopy; Roux Y anastomosis; South Korea; tertiary care center; total gastrectomy; total quality management; treatment response; university hospital; workplace; gallstone; procedures; treatment outcome | English | 2023 | 2023-05 | 10.5009/gnl220117 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Oral Sulfate Solution Is as Effective as Polyethylene Glycol with Ascorbic Acid in a Split Method for Bowel Preparation in Patients with Inactive Ulcerative Colitis: A Randomized, Multicenter, and Single-Blind Clinical Trial | Background/Aims: Low-volume preparations for colonoscopy are gaining attention for their higher acceptability. However, the efficacy and safety of oral sulfate solution (OSS) preparations in patients with ulcerative colitis (UC) has not been well known. Therefore, we aimed to compare OSS and 2-L polyethylene glycol with ascorbic acid (PEG+Asc) for bowel preparation in inactive UC.Methods: A multicenter, randomized, single-blind study was conducted at six tertiary referral hos-pitals in Korea. Outpatients with UC who had stable disease activity were randomly allocated to the OSS group or the 2-L PEG+Asc group for bowel preparation before colonoscopy. The study outcomes included treatment efficacy, safety, tolerability, and acceptability. Bowel cleansing was assessed using the Boston Bowel Preparation Scale and rated as successful cleansing if the score was >= 6. Patient acceptance and tolerability were assessed using a 4-point ordinal scale. Additionally, disease activity and laboratory data before and after colonoscopy were evaluated to check for safety.Results: The OSS and 2-L PEG+Asc groups included 92 and 93 participants, respectively. No significant between-group difference was noted in successful cleansing (OSS [96.7%] vs 2-L PEG+Asc [97.8%], p=0.64). Moreover, the safety, acceptance, and tolerability were not signifi-cantly different (all p>0.05). Furthermore, no significant changes were found in serum electrolytes or disease activity in either group.Conclusions: OSS is effective for colonoscopy cleansing, has acceptable tolerability, and does not affect disease activity; thus, it can be used safely for bowel preparation in patients with inac-tive UC. (Gut Liver, Published online January 2, 2023) | Lee, Ji Min; Lee, Kang-Moon; Kang, Ho Suk; Koo, Ja Seol; Lee, Hyun Seok; Jeong, Seok-Hoo; Kim, Jung Ho; Kim, Dae Bum | Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Hallym Univ, Coll Med, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; Korea Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Ansan Hosp, Ansan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Catholic Kwandong Univ, Int St Marys Hosp, Dept Internal Med, Div Gastroenterol, Kangnung, South Korea; Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea | ; Lee, Ji Min/KCZ-2783-2024; Kim, Jung/S-5543-2017; Kim, Jung Ho/S-5543-2017 | 57196135931; 35196099500; 56459291500; 24765936100; 36647886100; 55776598100; 57216274256; 56603423800 | drmaloman@catholic.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 17 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 3.4 | 30.4 | 1 | 2025-06-25 | 8 | 7 | Key Words; Oral sulfate solution; Colitis; ulcerative; Colonoscopy; Patient safety; Polyethylene glycol | COLORECTAL-CANCER; PRACTICE GUIDELINES; PLUS BISACODYL; COLONOSCOPY; EFFICACY; DISEASE; SURVEILLANCE; CITRATE; SAFETY; VOLUME | Colitis, ulcerative; Colonoscopy; Oral sulfate solution; Patient safety; Polyethylene glycol | Ascorbic Acid; Cathartics; Colitis, Ulcerative; Colonoscopy; Humans; Polyethylene Glycols; Single-Blind Method; Sulfates; ascorbic acid; endocol; macrogol; simethicone; sulfuric acid; ascorbic acid; laxative; sulfate; adult; Article; colitis; colon lavage; colonoscopy; controlled study; disease activity; drug safety; drug tolerability; electrolyte blood level; female; human; human tissue; intestine preparation; Korea; major clinical study; male; Massachusetts; multicenter study; outcome assessment; outpatient; patient safety; randomized controlled trial; single blind procedure; tertiary care center; ulcerative colitis; clinical trial; procedures; ulcerative colitis | English | 2023 | 2023-07 | 10.5009/gnl220202 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Rehabilitation Program for Improved Musculoskeletal Pain in Gastrointestinal Endoscopists: Multicenter Prospective Cohort Study | Background/Aims: This study aimed to develop a rehabilitation program for musculoskeletal pain experienced by gastrointestinal endoscopists and to investigate its usefulness.Methods: This was a multicenter cohort study. During the first 2 weeks, a questionnaire regarding daily workload and musculoskeletal symptoms was administered. Then, a rehabilitation program including equipment/posture correction and stretching was conducted during the remaining 6 weeks. Follow-up daily workload and musculoskeletal symptom surveys were distributed during the last 2 weeks. The program satisfaction survey was performed at the 6th and 8th weeks.Results: Among 118 participants (69 men), 94% (n=111) complained of musculoskeletal pain at baseline. Various hospital activities at baseline were associated with multisite musculoskeletal pain, whereas only a few workloads were correlated with musculoskeletal pain after the rehabilitation program. Follow-up musculoskeletal pain was negatively correlated with equipment/ posture program performance; arm/elbow pain was negatively correlated with elbow (R=-0.307) and wrist (R=-0.205) posture; leg/foot pain was negatively correlated with monitor position, shoulder, elbow, wrist, leg, and foot posture. Higher performance in the scope position (86.8% in the improvement vs 71.3% in the aggravation group, p=0.054) and table height (94.1% vs 79.1%, p=0.054) were associated with pain improvement. An increased number of colonoscopy procedures (6.27 in the aggravation vs 0.02 in the improvement group, p=0.017) was associated with pain aggravation. Most participants reported being average (32%) or satisfied (67%) with the program at the end of the study.Conclusions: Our rehabilitation program is easily applicable, satisfactory, and helpful for improving the musculoskeletal pain experienced by gastrointestinal endoscopists. (Gut Liver, Published online January 2, 2023) | Nam, Su Youn; Nam, Kwangwoo; Shim, Ki-Nam; Yang, Seoyon; Tae, Chung Hyun; Jo, Junwoo; Kim, Nayoung; Park, Seon Mi; Park, Young Sook; Park, Seon Ja; Jung, Sung-Ae | Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Dankook Univ Hosp, Dankook Univ Coll Med, Dept Internal Med, Cheonan, South Korea; Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Ewha Womans Univ, Dept Rehabil Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Seoul Natl Univ Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Seoul Natl Univ Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju, South Korea; Eulji Univ, Eulji Hosp, Dept Internal Med, Sch Med, Seoul, South Korea; Kosin Univ, Dept Internal Med, Coll Med, Pusan, South Korea | ; KIM, JEONGSEON/AAA-4643-2022; Kim, Nayoung/J-5387-2012; Nam, Kwangwoo/KLD-2723-2024 | 55617028500; 56650545300; 13604838300; 55999119300; 35211966400; 57210425017; 57201181440; 57022254400; 57203871380; 57206639713; 7403676915 | shimkn@ewha.ac.kr;jassa@ewha.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 17 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 3.4 | 30.4 | 0.57 | 2025-06-25 | 3 | 4 | Musculoskeletal pain; Workload; Endoscopist; Equipment; Rehabilitation | ERGONOMICS; INJURIES; OVERUSE; POSTURE | Endoscopist; Equipment; Musculoskeletal pain; Rehabilitation; Workload | Cohort Studies; Humans; Male; Musculoskeletal Pain; Occupational Diseases; Prospective Studies; Risk Factors; adult; arm pain; Article; body position; cohort analysis; colonoscopy; endoscopist; female; follow up; foot pain; gastrointestinal endoscopist; human; major clinical study; male; musculoskeletal pain; neck pain; pain severity; prevalence; prospective study; rehabilitation care; risk factor; shoulder pain; workload; clinical trial; multicenter study; occupational disease | English | 2023 | 2023-11 | 10.5009/gnl220103 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Relationship between the High Fatty Liver Index and Risk of Fracture | Background/Aims: The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased rapidly as a consequence of more sedentary lifestyles and a Westernized diet. Fracture is a major clinical problem in older people, but few large-scale cohort studies have evaluated the relationship between NAFLD and fracture. Therefore, we aimed to determine whether the fatty liver index (FLI), which represents the severity of NAFLD, can predict fracture risk. Methods: We analyzed the relationship between the FLI and incident fracture using multivariate Cox proportional hazards models and data for 180,519 individuals who underwent National Health check-ups in the Republic of Korea between 2009 and 2014. Results: A total of 2,720 participants (1.5%) were newly diagnosed with fracture during the study period (median 4.6 years). The participants were grouped according to FLI quartiles (Q1, 0 to <5.653; Q2, 5.653 to <15.245; Q3, 15.245 to <37.199; and Q4 =37.199). The cumulative fracture incidence was significantly higher in the highest FLI group than in the lowest FLI group (Q4, 986 [2.2%] and Q1, 323 [0.7%]; p<0.001). The adjusted hazard ratio indicated that the highest FLI group was independently associated with a higher incidence of fracture (hazard ratio for Q4 vs Q1, 2.956; 95% confidence interval, 2.606 to 3.351; p<0.001). FLI was significantly associated with a higher incidence of fracture, independent of the baseline characteristics of the participants. Conclusions: Our data imply that the higher the FLI of a Korean patient is, the higher their risk of osteoporotic fracture, independent of key confounding factors. | Kim, Min-Ji; Kim, Min-Su; Lee, Han-Byul; Roh, Jae-Hyung; Jeon, Jae-Han | Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Chungnam Natl Univ, Coll Med, Dept Internal Med, Sejong Hosp, Sejong, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu, South Korea | Kim, Min-Ji/Z-5205-2019 | 57206189095; 57208554686; 59107079300; 57216309871; 36910340400 | jhroh80@gmail.com;jeonjh@knu.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 17 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 3.4 | 30.4 | 1.14 | 2025-06-25 | 8 | 8 | Non-alcoholic fatty liver disease; Osteoporotic fracture; Fatty liver index; Fatty liver | BONE-MINERAL DENSITY; GAMMA-GLUTAMYL-TRANSFERASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; DISEASE; ASSOCIATION; EPIDEMIOLOGY; OSTEOPOROSIS; STEATOSIS; OBESITY | Fatty liver; Fatty liver index; Non-alcoholic fatty liver disease; Osteoporotic fracture | Aged; Body Mass Index; Cohort Studies; Humans; Incidence; Non-alcoholic Fatty Liver Disease; Republic of Korea; Risk Factors; steroid; vitamin D; adult; Article; cohort analysis; confidence interval; cross-sectional study; disease association; disease classification; disease severity; fatty liver index; female; fracture risk assessment; fragility fracture; hazard ratio; human; incidence; major clinical study; male; nonalcoholic fatty liver; nonhuman; prediction; prevalence; proportional hazards model; retrospective study; South Korean; statistical significance; aged; body mass; complication; nonalcoholic fatty liver; risk factor; South Korea | English | 2023 | 2023-01 | 10.5009/gnl210571 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Revised Clinical Practice Guidelines of the Korean Pancreatobiliary Association for Acute Pancreatitis | Acute pancreatitis can range from a mild, self-limiting disease requiring no more than supportive care, to severe disease with life-threatening complications. With the goal of providing a recommendation framework for clinicians to manage acute pancreatitis, and to contribute to improvements in national health care, the Korean Pancreatobiliary Association (KPBA) established the Korean guidelines for acute pancreatitis management in 2013. However, many challenging issues exist which often lead to differences in clinical practices. In addition, with newly obtained evidence regarding acute pancreatitis, there have been great changes in recent knowledge and information regarding this disorder. Therefore, the KPBA committee underwent an extensive revision of the guidelines. The revised guidelines were developed using the Delphi method, and the main topics of the guidelines include the following: diagnosis, severity assessment, initial treatment, nutritional support, convalescent treatment, and the treatment of local complications and necrotizing pancreatitis. Specific recommendations are presented, along with the evidence levels and recommendation grades. | Lee, Sang Hyub; Choe, Jung Wan; Cheon, Young Koog; Choi, Miyoung; Jung, Min Kyu; Jang, Dong Kee; Jo, Jung Hyun; Lee, Jae Min; Kim, Eui Joo; Han, Sung Yong; Choi, Young Hoon; Seo, Hyung-Il; Lee, Dong Ho; Lee, Hong Sik | Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Liver Res Inst, Coll Med, Seoul, South Korea; Korea Univ, Coll Med, Ansan Hosp, Dept Internal Med, Ansan, South Korea; Konkuk Univ, Sch Med, Med Ctr, Dept Internal Med, Seoul, South Korea; Natl Evidence Based Healthcare Collaborating Agcy, Div Hlth Technol Assessment Res, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul Metropolitan Govt,Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Changwon Hosp, Chang Won, South Korea; Gachon Univ, Dept Internal Med, Gil Med Ctr, Coll Med, Incheon, South Korea; Pusan Natl Univ, Sch Med, Biomed Res Inst, Pusan Natl Univ Hosp,Dept Internal Med, Busan, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst, Dept Surg,Sch Med, Busan, South Korea; Seoul Natl Univ, Coll Med, Dept Radiol, Seoul Natl Univ Hosp, Seoul, South Korea; Korea Univ, Coll Med, Anam Hosp, Dept Internal Med, Seoul, South Korea | Jo, Jung Hyun/V-8316-2019; Kim, Eui/P-8348-2019; Lee, Jun Young/CAI-2335-2022; Choi, Miyoung/HZH-8501-2023; Kim, Young/J-5414-2012; Lee, Hyo-Suk/J-5618-2012; Lee, Dong-Ho/J-5576-2012 | 36062488800; 56481120200; 55634340400; 57129603200; 56783168100; 56091787300; 55532796800; 56557482500; 36102878900; 57190127827; 57212256431; 26425277100; 57222878418; 55663670000 | hslee60@korea.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 17 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2023 | 3.4 | 30.4 | 0.85 | 2025-06-25 | 12 | 11 | Acute pancreatitis; Management; Guideline; Evidence-based medicine | ALCOHOL-ASSOCIATED PANCREATITIS; ENHANCED COMPUTED-TOMOGRAPHY; MILD GALLSTONE PANCREATITIS; RANDOMIZED CONTROLLED-TRIAL; CLEAR LIQUID DIET; STEP-UP APPROACH; NECROTIZING PANCREATITIS; HOSPITAL VOLUME; ORGAN FAILURE; INITIAL MEAL | Acute pancreatitis; Evidence-based medicine; Guideline; Management | Acute Disease; Humans; Pancreatitis, Acute Necrotizing; Republic of Korea; acute hemorrhagic pancreatitis; acute pancreatitis; clinical practice; clinician; Delphi study; disease severity assessment; evidence based medicine; health care organization; human; Korean (people); nutritional support; practice guideline; public health service; Review; acute disease; acute hemorrhagic pancreatitis; South Korea | English | 2023 | 2023-01 | 10.5009/gnl220108 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Cbfβ Is a Novel Modulator against Osteoarthritis by Maintaining Articular Cartilage Homeostasis through TGF-β Signaling | TGF-beta signaling is a vital regulator for maintaining articular cartilage homeostasis. Runx transcription factors, downstream targets of TGF-beta signaling, have been studied in the context of osteoarthritis (OA). Although Runx partner core binding factor beta (Cbf beta) is known to play a pivotal role in chondrocyte and osteoblast differentiation, the role of Cbf beta in maintaining articular cartilage integrity remains obscure. This study investigated Cbf beta as a novel anabolic modulator of TGF-beta signaling and determined its role in articular cartilage homeostasis. Cbf beta significantly decreased in aged mouse articular cartilage and human OA cartilage. Articular chondrocyte-specific Cbfb-deficient mice (Cbfb4ac/ 4ac) exhibited early cartilage degeneration at 20 weeks of age and developed OA at 12 months. Cbfb4ac/ 4ac mice showed enhanced OA progression under the surgically induced OA model in mice. Mechanistically, forced expression of Cbf beta rescued Type II collagen (Col2 alpha 1) and Runx1 expression in Cbf beta-deficient chondrocytes. TGF-beta 1-mediated Col2ff1 expression failed despite the p-Smad3 activation under TGF-beta 1 treatment in Cbf beta-deficient chondrocytes. Cbf beta protected Runx1 from proteasomal degradation through Cbf beta/Runx1 complex formation. These results indicate that Cbf beta is a novel anabolic regulator for cartilage homeostasis, suggesting that Cbf beta could protect OA development by maintaining the integrity of the TGF-beta signaling pathway in articular cartilage. | Che, Xiangguo; Jin, Xian; Park, Na Rae; Kim, Hee-June; Kyung, Hee-Soo; Kim, Hyun-Ju; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.; Choi, Je-Yong | Kyungpook Natl Univ, Cell & Matrix Res Inst, Korea Mouse Phenotyping Ctr KMPC, Sch Med,Dept Biochem & Cell Biol, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, Daegu 41944, South Korea; Univ Vermont, Univ Vermont Canc Ctr, Larner Coll Med, Burlington, VT 05405 USA; Univ Vermont, Larner Coll Med, Dept Biochem, Burlington, VT 05405 USA | Choi, Je-Yong/AAR-7334-2021 | 54792660600; 57204810645; 24492053700; 36463735200; 7004292406; 57208650339; 57662546800; 35418570500; 57896267700; 7501391068 | jechoi@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 12 | 7 | SCIE | CELL BIOLOGY | 2023 | 5.1 | 30.5 | 0.94 | 2025-06-25 | 11 | 9 | articular cartilage; Runx1/Cbf beta complex; osteoarthritis; TGF-beta signaling; proteasomal degradation | BINDING-FACTOR BETA; TRANSCRIPTION FACTOR; CHONDROCYTE MATURATION; OSTEOPHYTE FORMATION; BONE-FORMATION; DIFFERENTIATION; EXPRESSION; RECEPTOR; RUNX2; INDUCTION | articular cartilage; osteoarthritis; proteasomal degradation; Runx1/Cbfβ complex; TGF-β signaling | Animals; Cartilage, Articular; Core Binding Factor Alpha 2 Subunit; Core Binding Factor beta Subunit; Homeostasis; Humans; Mice; Osteoarthritis; Signal Transduction; Transforming Growth Factor beta1; beta galactosidase; collagen; collagen type 1; collagen type 2; collagenase 3; core binding factor beta; interleukin 17; interleukin 18; Smad3 protein; transcription factor; core binding factor beta; transcription factor RUNX1; transforming growth factor beta1; animal cell; animal experiment; Article; articular cartilage; ATDC-5 cell line; bone density; burnout; cartilage degeneration; CBFB gene; cell culture; cell cycle progression; cell differentiation; chondrocyte; coimmunoprecipitation; complex formation; female; gene; gene expression; genetic transfection; histochemistry; histology; homeostasis; human; hypertension; immunoblotting; immunofluorescence assay; immunohistochemistry; immunoprecipitation; male; mesenchymal stem cell; metatarsophalangeal joint; mouse; nonhuman; osteoarthritis; osteoblast; osteoclast; osteolysis; phenotype; real time polymerase chain reaction; rheumatoid arthritis; surgical technique; TGF beta signaling; total knee arthroplasty; ubiquitination; Western blotting; animal; homeostasis; metabolism; signal transduction | English | 2023 | 2023-04 | 10.3390/cells12071064 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Enhanced Physiological and Biochemical Performance of Mung Bean and Maize under Saline and Heavy Metal Stress through Application of Endophytic Fungal Strain SL3 and Exogenous IAA | Modern irrigation practices and industrial pollution can contribute to the simultaneous occurrence of salinity and heavy metal contamination in large areas of the world, resulting in significant negative effects on crop productivity and sustainability. This study aimed to investigate the growth-promoting potentials of an important endophytic fungal strain SL3 and to compare its potential with exogenous IAA (indole-3-acetic acid) in the context of salt and heavy metal stress. The strain was assessed for plant growth-promoting traits such as the production of indole-3-acetic acid, gibberellins (GA), and siderophore. We selected two important crops, mung bean and maize, and examined various physiological and biochemical characteristics under 300 mM NaCl and 2.5 mM Pb stress conditions, with and without the application of IAA and SL3. This study's results demonstrated that both IAA and SL3 positively impacted the growth and development of plants under normal and stressed conditions. In NaCl and Pb-induced stress conditions, the growth of mung bean and maize plants was significantly reduced. However, the application of IAA and SL3 helped to alleviate stress, leading to a significant increase in shoot/root length and weight compared to IAA and SL3 non-treated plants. The results revealed that photosynthetic pigments, accumulation of catalase (CAT), phenolic contents, polyphenol oxidase, and flavanols are higher in the IAA and SL3-treated plants than in the non-inoculated plants. This study's findings revealed that applying the SL3 fungal strain positively influenced various physiological and biochemical processes in tested plant species under normal and stress conditions of NaCl and Pb. These findings also suggested that SL3 could be a potential replacement for widely used IAA to promote plant growth by improving photosynthetic efficiency, reducing oxidative stress, and enhancing metabolic activities in plants, including mung and maize. Moreover, this study highlights that SL3 has synergistic effects with IAA in enhancing resilience to salt and heavy stress and offers a promising avenue for future agricultural applications in salt and heavy metal-affected regions. | Aizaz, Muhammad; Khan, Ibrahim; Lubna; Asaf, Sajjad; Bilal, Saqib; Jan, Rahmatullah; Khan, Abdul Latif; Kim, Kyung-Min; AL-Harrasi, Ahmed | Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Univ Houston, Dept Engn Technol, Sugar Land, TX 77479 USA | ; Jan, Rahmatullah/AIC-3439-2022; Khan, Abdul/H-5910-2011; Khan, Ibrahim/JMC-5061-2023; Kim, Kyung-Min Kim/C-7007-2014; Ul-Hamid, Anwar/B-7297-2015; Asaf, Sajjad/ABA-3647-2021 | 57224641342; 57191379139; 57200621537; 56595059900; 57031617400; 57201981969; 26639372800; 34868260300; 6506093146 | aizaz@unizwa.edu.om;ibrahimkhan@unizwa.edu.om;lubnabilal68@gmail.com;sajadasif2000@gmail.com;rehmatbot@yahoo.com;alkhan@central.uh.edu;kkm@knu.ac.kr;aharrasi@unizwa.edu.om; | CELLS | CELLS-BASEL | 2073-4409 | 12 | 15 | SCIE | CELL BIOLOGY | 2023 | 5.1 | 30.5 | 1.98 | 2025-06-25 | 14 | 20 | mung bean; maize; endophytes; salinity; heavy metals; sustainable agriculture; oxidative stress | PLANT GROWTH; SALT; TOLERANCE; ACID; IMPROVES; ASSAY; LEAD | endophytes; heavy metals; maize; mung bean; oxidative stress; salinity; sustainable agriculture | Agricultural Irrigation; Fungi; Metals, Heavy; Plant Growth Regulators; Salinity; Soil Microbiology; Soil Pollutants; Vigna; Zea mays; flavanol derivative; gibberellin; indoleacetic acid; lead; phytohormone; polyphenol; siderophore; sodium chloride; heavy metal; abiotic stress; antioxidant activity; Article; biochemistry; cytotoxicity; fungal strain; Fusarium proliferatum; Heavy Metal Stress; high performance liquid chromatography; ion monitoring; maize; mass fragmentography; mung bean; nonhuman; oxidative stress; phylogeny; plant growth; pollution; salinity; salt stress; synergistic effect; classification; drug effect; fungus; growth, development and aging; irrigation (agriculture); maize; metabolism; microbiology; soil pollutant; Vigna | English | 2023 | 2023-08 | 10.3390/cells12151960 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of Blood Tumor Mutation Burden for the Efficacy of Second-Line Atezolizumab Treatment in Non-Small Cell Lung Cancer: BUDDY Trial | This study aimed to investigate the feasibility of blood-based biomarkers, including blood tumor mutation burden (bTMB), to predict atezolizumab efficacy in relapsed and advanced non-small cell lung cancer (NSCLC). Stage IV NSCLC patients who had previously received platinum-doublet chemotherapy were recruited and received 1200 mg of atezolizumab every three weeks. Blood was collected to obtain plasma cell-free DNA (cfDNA) before the first cycle (C0) and at the fourth cycle (C4). bTMB was measured by CT-ULTRA in patients with cfDNA over 10 ng. The objective response rate (ORR) of the enrolled 100 patients was 10%, and there was no difference in ORR according to bTMB (cutoff: 11.5 muts/Mb) at C0 (high bTMB: 8.1% vs. low bTMB: 11.1%). However, the C4/C0 bTMB ratio was significantly lower in the durable clinical benefit (DCB) patients. The cfDNA concentration at C0, the C4/C0 ratio of the cfDNA concentration, the highest variant allele frequency (hVAF), and the VAF standard deviation (VAFSD) were significantly lower in the DCB patients. In the multivariate analysis, a high cfDNA concentration at C0 (cutoff: 8.6 ng/mL) and a C4/C0 bTMB ratio greater than 1 were significantly associated with progression-free survival. These results suggest that baseline levels and dynamic changes of blood-based biomarkers (bTMB, cfDNA concentration, and VAFSD) could predict atezolizumab efficacy in previously treated NSCLC patients. | Park, Cheol-Kyu; Jun, Ha Ra; Oh, Hyung-Joo; Lee, Ji-Young; Cho, Hyun-Ju; Kim, Young-Chul; Lee, Jeong Eun; Yoon, Seong Hoon; Choi, Chang Min; Lee, Jae Cheol; Lee, Sung Yong; Lee, Shin Yup; Chun, Sung-Min; Oh, In-Jae | Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Internal Med, Gwangju 58128, South Korea; Univ Ulsan, Asan Med Inst Convergence Sci & Technol, Asan Med Ctr,Coll Med, Dept Med Sci, Seoul 05505, South Korea; Chungnam Natl Univ Hosp, Dept Internal Med, Daejeon 35015, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Pusan 50612, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Oncol, Seoul 05505, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Seoul 08308, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Dept Pathol, Seoul 05505, South Korea | ; Kim, Yong-Joo/AAK-1840-2021; Oh, In-Jae/AAG-5919-2020; Park, Cheol-Kyu/AAT-9872-2021; Lee, Jeong Eun/R-8689-2019; Lee, Joo Yong/ADE-2110-2022; Lee, Jae/AAA-2678-2021 | 57205721111; 58067446400; 57216363864; 59641355800; 57203225202; 35201246200; 57209104622; 55479240500; 14024046800; 24825051600; 56734650000; 49863712700; 55775173200; 58754601500 | ckpark214@jnu.ac.kr;3143137@naver.com;ohj4250@naver.com;easy0@hanmail.net;repair2799@hanmail.net;kyc0923@jnu.ac.kr;jelee0210@cnu.ac.kr;dognose79@naver.com;ccm9607@gmail.com;jclee@amc.seoul.kr;syl0801@korea.ac.kr;shinyup@knu.ac.kr;smchun@amc.seoul.kr;droij@jnu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 12 | 9 | SCIE | CELL BIOLOGY | 2023 | 5.1 | 30.5 | 0.52 | 2025-06-25 | 5 | 6 | cell-free DNA; blood tumor mutation burden; atezolizumab; non-small cell lung cancer | INTRATUMOR HETEROGENEITY; SURVIVAL; BIOMARKERS; BENEFIT | atezolizumab; blood tumor mutation burden; cell-free DNA; non-small cell lung cancer | Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell-Free Nucleic Acids; Humans; Lung Neoplasms; Mutation; alanine aminotransferase; alkaline phosphatase; anaplastic lymphoma kinase; aspartate aminotransferase; atezolizumab; bilirubin; circulating free DNA; epidermal growth factor receptor; genomic DNA; hemoglobin; programmed death 1 ligand 1; atezolizumab; cell free nucleic acid; tumor marker; absolute neutrophil count; adult; aged; area under the curve; Article; cancer staging; clinical outcome; cohort analysis; controlled clinical trial; controlled study; copy number variation; diagnostic test accuracy study; drug efficacy; ECOG Performance Status; EGFR signaling; female; gene frequency; gene mutation; high throughput sequencing; human; human tissue; immunohistochemistry; intention to treat analysis; leukocyte count; major clinical study; male; multicenter study; multiple cycle treatment; neutrophil lymphocyte ratio; non small cell lung cancer; overall survival; polymerase chain reaction; progression free survival; prospective study; protein expression; receiver operating characteristic; single nucleotide polymorphism; smoking; tumor mutational burden; x-ray computed tomography; genetics; lung tumor; metabolism; mutation; non small cell lung cancer; pathology | English | 2023 | 2023-04-25 | 10.3390/cells12091246 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Editorial Material | Function of Glial Cells in Neuroinflammatory and Neuroimmunological Responses II | Afridi, Ruqayya; Bhusal, Anup; Tsuda, Makoto; Ryu, Hoon; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Kyungpook Natl Univ, Brain Korea Four KNU Convergence Educ Program Biom, Daegu 41940, South Korea; Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Mol & Syst Pharmacol, Fukuoka 8128582, Japan; Brain Sci Inst, Korea Inst Sci & Technol KIST, Ctr Neurosci, Seoul 02792, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41944, South Korea | Ryu, Hoon/MCJ-9411-2025 | 57200759784; 57200274141; 35425824100; 7202277209; 7005114595 | ksuk@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 12 | 13 | SCIE | CELL BIOLOGY | 2023 | 5.1 | 30.5 | 0.66 | 2025-06-25 | 2 | 2 | Central Nervous System; Neuroglia; Neurons; amyloid beta protein; cathelicidin; immunoglobulin enhancer binding protein; mitogen activated protein kinase; tau protein; Alzheimer disease; antibiotic resistance; apoptosis; cardiovascular disease; cell survival; degenerative disease; Editorial; episodic memory; glia cell; hippocampus; human; human cell; immune response; major depression; microglia; nerve cell plasticity; nerve degeneration; nervous system inflammation; neuroimmunology; neuroprotection; neurotoxicity; nonhuman; optogenetics; Parkinson disease; risk factor; Schisandra chinensis; signal transduction; transcriptomics; central nervous system; glia; nerve cell | English | 2023 | 2023-07 | 10.3390/cells12131750 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | IRF3 Activation in Mast Cells Promotes FcεRI-Mediated Allergic Inflammation | (1) Background: This study aims to elucidate a novel non-transcriptional action of IRF3 in addition to its role as a transcription factor in mast cell activation and associated allergic inflammation; (2) Methods: For in vitro experiments, mouse bone-marrow-derived mast cells (mBMMCs) and a rat basophilic leukemia cell line (RBL-2H3) were used for investigating the underlying mechanism of IRF3 in mast-cell-mediated allergic inflammation. For in vivo experiments, wild-type and Irf3 knockout mice were used for evaluating IgE-mediated local and systemic anaphylaxis; (3) Results: Passive cutaneous anaphylaxis (PCA)-induced tissues showed highly increased IRF3 activity. In addition, the activation of IRF3 was observed in DNP-HSA-treated mast cells. Phosphorylated IRF3 by DNP-HSA was spatially co-localized with tryptase according to the mast cell activation process, and FceRI-mediated signaling pathways directly regulated that activity. The alteration of IRF3 affected the production of granule contents in the mast cells and the anaphylaxis responses, including PCA- and ovalbumin-induced active systemic anaphylaxis. Furthermore, IRF3 influenced the post-translational processing of histidine decarboxylase (HDC), which is required for granule maturation; and (4) Conclusion: Through this study, we demonstrated the novel function of IRF3 as an important factor inducing mast cell activation and as an upstream molecule for HDC activity. | Choi, Young-Ae; Dhakal, Hima; Lee, Soyoung; Kim, Namkyung; Lee, Byungheon; Kwon, Taeg Kyu; Khang, Dongwoo; Kim, Sang-Hyun | Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup 56212, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Keimyung Univ, Sch Med, Dept Immunol, Daegu 42601, South Korea; Gachon Univ, Sch Med, Dept Physiol, Incheon 21999, South Korea | ; Kim, Sang-Hyun/KQU-4555-2024 | 7404777420; 57195999763; 8537269200; 57216981866; 16304374900; 7202206057; 26039177500; 57210450420 | wizchoi@knu.ac.kr;dhakalhima@gmail.com;sylee@kribb.re.kr;nortonnklab@gmail.com;leebh@knu.ac.kr;kwontk@dsmc.or.kr;dkhang@gachon.ac.kr;shkim72@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 12 | 11 | SCIE | CELL BIOLOGY | 2023 | 5.1 | 30.5 | 0.31 | 2025-06-25 | 3 | 3 | allergic inflammation; histamine; histidine decarboxylase; interferon regulatory factor 3; mast cells | INTERFERON REGULATORY FACTOR-3; HISTIDINE-DECARBOXYLASE; GRANULE MATURATION; HISTAMINE; MECHANISMS | allergic inflammation; histamine; histidine decarboxylase; interferon regulatory factor 3; mast cells | Anaphylaxis; Animals; Cell Line; Inflammation; Mast Cells; Mice; Rats; Receptors, IgE; epsilon opiate receptor; Fc epsilon receptor 1; histidine decarboxylase; immunoglobulin E; interferon regulatory factor 3; interleukin 4; interleukin 6; plasmid DNA; small interfering RNA; transcription factor; tryptase; tumor necrosis factor; unclassified drug; immunoglobulin E receptor; allergic inflammation; anaphylaxis; animal cell; animal experiment; animal model; animal tissue; Article; basophilic leukemia cell line; beta hexosaminidase assay; bioassay; bone marrow derived mast cell; cell activation; cell culture; cell isolation; degranulation; enzyme linked immunosorbent assay; flow cytometry; histamine assay; immunofluorescence; in vitro study; in vivo study; mast cell; mast cell degranulation; mouse; nonhuman; protein expression; rat; real time polymerase chain reaction; signal transduction; Western blotting; anaphylaxis; animal; cell line; inflammation; mast cell; metabolism | English | 2023 | 2023-05-28 | 10.3390/cells12111493 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Microglial Responses to Stress-Induced Depression: Causes and Consequences | Chronic stress is a major risk factor for various psychiatric diseases, including depression; it triggers various cellular and structural changes, resulting in the alteration of neurocircuitry and subsequent development of depression. Accumulating evidence suggests that microglial cells orchestrate stress-induced depression. Preclinical studies of stress-induced depression revealed microglial inflammatory activation in regions of the brain that regulate mood. Although studies have identified several molecules that trigger inflammatory responses in microglia, the pathways that regulate stress-induced microglial activation remain unclear. Understanding the exact triggers that induce microglial inflammatory activation can help find therapeutic targets in order to treat depression. In the current review, we summarize the recent literature on possible sources of microglial inflammatory activation in animal models of chronic stress-induced depression. In addition, we describe how microglial inflammatory signaling affects neuronal health and causes depressive-like behavior in animal models. Finally, we propose ways to target the microglial inflammatory cascade to treat depressive disorders. | Afridi, Ruqayya; Suk, Kyoungho | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Kyungpook Natl Univ, Brain Korea 21 Four KNU Convergence Educ Program B, Daegu 41940, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41944, South Korea | 57200759784; 7005114595 | ksuk@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 12 | 11 | SCIE | CELL BIOLOGY | 2023 | 5.1 | 30.5 | 1.04 | 2025-06-25 | 16 | 18 | chronic stress; depression; microglia; neuroinflammation; proinflammatory cytokines | LIVER X RECEPTORS; HIPPOCAMPAL NEUROGENESIS; SYNAPTIC PLASTICITY; WHITE-MATTER; BONE-MARROW; BRAIN; NEUROBIOLOGY; RESILIENCE; ACTIVATION; DISORDER | chronic stress; depression; microglia; neuroinflammation; proinflammatory cytokines | Animals; Brain; Depression; Microglia; Neurons; Signal Transduction; 3 [3 [[2 chloro 3 (trifluoromethyl)benzyl](2 diphenylethyl)amino]propoxy]phenylacetic acid; advanced glycation end product receptor; asperosaponin 6; astragalin; biological factor; brain derived neurotrophic factor; CD11b antigen; colony stimulating factor 1 receptor; complement component C1q; complement component C3; complement receptor 3; cryopyrin; cyclic AMP responsive element binding protein; diazepam; dimethyl fumarate; high mobility group B1 protein; immunoglobulin enhancer binding protein; interleukin 10; interleukin 1beta; interleukin 4; ketamine; liver X receptor beta; mcc950; methyl CpG binding protein 2; minocycline; mitogen activated protein kinase 1; mitogen activated protein kinase 3; mitogen activated protein kinase p38; nuclear receptor binding protein 1; peroxisome proliferator activated receptor gamma; protein inhibitor; reactive oxygen metabolite; recombinant protein; roflupram; sulforaphane; to90137; toll like receptor 4; transcription factor Nrf2; tumor necrosis factor; unclassified drug; autophagy (cellular); brain immune axis; chronic stress; damage associated molecular pattern; dendritic spine density; depression; human; hyperactivity; hypothalamus hypophysis adrenal system; impaired synaptic plasticity; microglial activation; microglial inflammatory activation; microglial inflammatory signaling; microglial responses; nervous system development; nervous system function; nervous system inflammation; neuronal damage; neuronal health; neuronal signals; neurotrophic signaling; nonhuman; organ systems; phagocytosis; protein expression; Review; signal transduction; stress induced depression; animal; brain; depression; metabolism; microglia; nerve cell | English | 2023 | 2023-05-31 | 10.3390/cells12111521 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Nalfurafine Hydrochloride, a κ-Opioid Receptor Agonist, Induces Melanophagy via PKA Inhibition in B16F1 Cells | Selective autophagy controls cellular homeostasis by degrading unnecessary or damaged cellular components. Melanosomes are specialized organelles that regulate the biogenesis, storage, and transport of melanin in melanocytes. However, the mechanisms underlying melanosomal autophagy, known as the melanophagy pathway, are poorly understood. To better understand the mechanism of melanophagy, we screened an endocrine-hormone chemical library and identified nalfurafine hydrochlorides, a kappa-opioid receptor agonist, as a potent inducer of melanophagy. Treatment with nalfurafine hydrochloride increased autophagy and reduced melanin content in alpha-melanocyte-stimulating hormone (alpha-MSH)-treated cells. Furthermore, inhibition of autophagy blocked melanosomal degradation and reversed the nalfurafine hydrochloride-induced decrease in melanin content in alpha-MSH-treated cells. Consistently, treatment with other kappa-opioid receptor agonists, such as MCOPPB or mianserin, inhibited excessive melanin production but induced autophagy in B16F1 cells. Furthermore, nalfurafine hydrochloride inhibited protein kinase A (PKA) activation, which was notably restored by forskolin, a PKA activator. Additionally, forskolin treatment further suppressed melanosomal degradation as well as the anti-pigmentation activity of nalfurafine hydrochloride in alpha-MSH-treated cells. Collectively, our data suggest that stimulation of kappa-opioid receptors induces melanophagy by inhibiting PKA activation in alpha-MSH-treated B16F1 cells. | Lee, Ha Jung; Kim, Seong Hyun; Kim, Yong Hwan; Kim, So Hyun; Oh, Gyeong Seok; Bae, Ji-Eun; Kim, Joon Bum; Park, Na Yeon; Park, Kyuhee; Yeom, Eunbyul; Jeong, Kwiwan; Kim, Pansoo; Jo, Doo Sin; Cho, Dong-Hyung | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; Gyeonggido Business & Sci Accelerator, Bio Ctr, Suwon 16229, Gyeonggi Do, South Korea; OGASIS Corp, 260 Changyong daero, Suwon 08826, South Korea | Choi, Hye Rin/JDV-9065-2023; Kim, Joon/ADP-8066-2022 | 57221856423; 57253406700; 57204676401; 57253406800; 57219084322; 57190605352; 57190611030; 57190609826; 57194598552; 56058004100; 57197993212; 56577113700; 56335489800; 35093684400 | doosinjo0131@knu.ac.kr;dhcho@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 12 | 1 | SCIE | CELL BIOLOGY | 2023 | 5.1 | 30.5 | 0.52 | 2025-06-25 | 5 | 5 | nalfurafine hydrochloride; autophagy; kappa-opioid receptor; melanophagy | AUTOPHAGY; PIGMENTATION; STIMULATION; BIOGENESIS; FORSKOLIN; SYSTEM; SKIN | autophagy; B16F1 cells; melanophagy; nalfurafine hydrochloride; κ-opioid receptor | alpha-MSH; Colforsin; Melanins; Receptors, Opioid, kappa; kappa opiate receptor agonist; melanin; nalfurafine; alpha intermedin; forskolin; kappa opiate receptor; melanin; nalfurafine; Article; autophagy (cellular); B16-F1 cell line; confocal microscopy; human; human cell; melanogenesis; melanophagy; protein expression; Western blotting | English | 2023 | 2023-01 | 10.3390/cells12010146 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Regulators of the Asexual Life Cycle of Aspergillus nidulans | The genus Aspergillus, one of the most abundant airborne fungi, is classified into hundreds of species that affect humans, animals, and plants. Among these, Aspergillus nidulans, as a key model organism, has been extensively studied to understand the mechanisms governing growth and development, physiology, and gene regulation in fungi. A. nidulans primarily reproduces by forming millions of asexual spores known as conidia. The asexual life cycle of A. nidulans can be simply divided into growth and asexual development (conidiation). After a certain period of vegetative growth, some vegetative cells (hyphae) develop into specialized asexual structures called conidiophores. Each A. nidulans conidiophore is composed of a foot cell, stalk, vesicle, metulae, phialides, and 12,000 conidia. This vegetative-to-developmental transition requires the activity of various regulators including FLB proteins, BrlA, and AbaA. Asymmetric repetitive mitotic cell division of phialides results in the formation of immature conidia. Subsequent conidial maturation requires multiple regulators such as WetA, VosA, and VelB. Matured conidia maintain cellular integrity and long-term viability against various stresses and desiccation. Under appropriate conditions, the resting conidia germinate and form new colonies, and this process is governed by a myriad of regulators, such as CreA and SocA. To date, a plethora of regulators for each asexual developmental stage have been identified and investigated. This review summarizes our current understanding of the regulators of conidial formation, maturation, dormancy, and germination in A. nidulans. | Son, Ye-Eun; Yu, Jae-Hyuk; Park, Hee-Soo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Major Food Biomat, Daegu 41566, South Korea; Univ Wisconsin Madison, Food Res Inst, Dept Bacteriol, Madison, WI 53706 USA; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea | ; Yu, Jae-Hyuk/A-2343-2008; Park, Hee-Soo/AAC-6422-2019 | 57200513491; 7405531243; 15751448400 | thsdpdms0407@naver.com;jyu1@wisc.edu;phsoo97@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 12 | 11 | SCIE | CELL BIOLOGY | 2023 | 5.1 | 30.5 | 0.92 | 2025-06-25 | 17 | 16 | Aspergillus nidulans; asexual development; conidial dormancy; conidial germination | CELL-WALL INTEGRITY; TRANSCRIPTION FACTOR; SECONDARY METABOLISM; SEXUAL DEVELOPMENT; NUCLEAR MIGRATION; STRESS RESPONSES; PROTEIN-KINASE; STERIGMATOCYSTIN BIOSYNTHESIS; SACCHAROMYCES-CEREVISIAE; CONIDIOPHORE DEVELOPMENT | asexual development; Aspergillus nidulans; conidial dormancy; conidial germination | Animals; Aspergillus nidulans; Fungal Proteins; Humans; Life Cycle Stages; Spores, Fungal; fungal protein; airborne fungus; Aspergillus; Aspergillus nidulans; conidium; developmental stage; dormancy; drought; foot; fungus hyphae; gene control; germination; human; life cycle; mitosis; nonhuman; physiological stress; review; vegetative growth; animal; fungus spore; genetics; life cycle stage; metabolism | English | 2023 | 2023-06-04 | 10.3390/cells12111544 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Role of Land-Atmosphere Interaction in the 2016 Northeast Asia Heat Wave: Impact of Soil Moisture Initialization | The impact of soil moisture initialization on the 2016 Northeast Asian heat wave was explored using the Land Information System (LIS) Weather Research and Forecasting (WRF) model. To obtain advanced soil moisture estimates, various meteorological variables from the Global Data Assimilation System analysis and Integrated Multi-Satellite Retrievals for Global Precipitation Measurement observation data were used as atmospheric forcings for the offline simulation of the Noah land surface model (Noah-LSM). Based on the LIS, Soil Moisture Active Passive satellite were assimilated in the Noah LSM simulation. The assimilated soil moisture estimates revealed the drier land surface conditions over Northeast Asia compared with the product from the National Centers for Environmental Prediction Final Analysis (FNL) and were used as the initial condition of the WRF model. The WRF experiment initialized by the assimilated soil moisture product (LIS experiment) exhibited the observed surface air temperature (SAT) and 500 hPa geopotential height (500 GPH) over Northeast Asia compared with the result from the experiment initialized by the FNL (CTL experiment). At Week 1, the LIS experiment simulated warmer SAT than that from the CTL experiment, which was induced by the negative anomaly of latent heat flux over Mongolia. Then, 500 GPH became strong and spatially expanded in response to the thermal low induced by the warmer SAT, and the SAT was further increased during Weeks 2 and 3. Plain Language Summary The association between soil moisture and land-atmosphere interaction occurring in the East Asia were analyzed by focusing on the 2016 extreme heat wave case. The numerical experiment with the initial soil moisture from the fusion of satellite data and land surface model output simulated a more realistic land-atmosphere interaction over East Asia within a 3-week heat wave simulation period, compared to the experiment with the operational soil moisture product. | Yoon, Donghyuck; Kang, Taehun; Cha, Dong-Hyun; Song, Chang-Keun; Lee, Myong-In; Min, Ki-Hong; Kim, Joowan; Chun, Jong Ahn; Seo, Eunkyo | Ulsan Natl Inst Sci & Technol, Dept Urban & Environm Engn, Ulsan, South Korea; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu, South Korea; Kongju Natl Univ, Dept Atmospher Sci, Gongju, South Korea; APEC Climate Ctr, Predict Res Dept, Busan, South Korea; Pukyong Natl Univ, Dept Environm Atmospher Sci, Busan, South Korea | ; Yoon, Donghyuck/ISS-5217-2023; Cha, Dong-Hyun/F-4901-2015; Lee, Myong-In/F-3578-2010; Song, Chang-Keun/S-2255-2016; Seo, Eunkyo/ABH-6269-2020 | 57204630556; 58084080800; 55418553100; 23028717700; 58530782000; 37089364100; 36637539100; 35094906400; 57201983930 | dhcha@unist.ac.kr;cksong@unist.ac.kr; | JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES | J GEOPHYS RES-ATMOS | 2169-897X | 2169-8996 | 128 | 2 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2023 | 3.8 | 30.5 | 1.71 | 2025-06-25 | 10 | 10 | heat wave; soil moisture initialization; land-atmosphere interaction | DATA ASSIMILATION; INFORMATION-SYSTEM; CLIMATE-CHANGE; EAST-ASIA; SURFACE; TEMPERATURE; WEATHER; PRECIPITATION; CONVECTION; FRAMEWORK | heat wave; land–atmosphere interaction; soil moisture initialization | Mongolia; Northeast Asia; air temperature; air-soil interaction; heat wave; land surface; latent heat flux; soil moisture; spatiotemporal analysis | English | 2023 | 2023-01-27 | 10.1029/2022jd037718 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Korean hip fracture registry study | BackgroundThe purpose of the Korean Hip Fracture Registry (KHFR) Study is to establish a nationwide, hospital-based prospective cohort study of adults with hip fracture to explore the incidence and risk factors of second osteoporotic fractures for a Fracture Liaison Service (FLS) model.MethodsThe KHFR, a prospective multicenter longitudinal study, was launched in 2014. Sixteen centers recruited participants who were treated for hip fracture. The inclusion criteria were patients, who were treated for proximal femur fracture due to low-energy trauma and aged 50 or more at the time of injury. Until 2018, 5,841 patients were enrolled in this study. Follow-up surveys were conducted annually to determine occurrence of second osteoporotic fracture, and 4,803 participants completed at least one follow-up survey.DiscussionKHFR is a unique resource of individual level on osteoporotic hip fracture with radiological, medical, and laboratory information including DXA (dual energy x-ray absorptiometry), bone turnover marker, body composition, and hand grip strength for future analyses for FLS model. Modifiable factors for mortality after hip surgery is planned to be identified with nutritional assessment and multi-disciplinary interventions from hospitalization to follow-ups. The proportions of femoral neck, intertrochanteric, and subtrochanteric fractures were 517 (42.0%), 730 (53.6%), and 60 (4.4%), respectively, from 2014 to 2016, which was similar in other studies. Radiologic definition of atypical subtrochanteric fracture was adopted and 17 (1.2%) fractures among 1,361 proximal femoral fractures were identified. Internal fixation showed higher reoperation rate compared to arthroplasty in unstable intertrochanteric fractures (6.1% vs. 2.4%, p = 0.046) with no significant difference in mortality. The KHFR plans to identify outcomes and risk factors associated with second fracture by conducting a 10-year cohort study, with a follow-up every year, using 5,841 baseline participants. Key messagesThe KHFR study, which is a representative of the Korean hip fracture patients, showed that basic epidemiologic information of hip fracture including atypical hip fracture in Korea.Perioperative nutritional assessment and management by multi-disciplinary interventions could decrease malnutrition and mortality risk.Internal fixation in unstable intertrochanteric fracture was associated with higher reoperation rate, comparing with bipolar hemiarthroplasty, while mortality after surgery was not significantly differ according to the type of surgery.Prospective cohort and representative registry should be established to develop effective secondary prevention program such as Fracture Liaison Service. | Park, Jung-Wee; Ha, Yong-Chan; Kim, Jin-Woo; Kim, Tae-Young; Kim, Ji Wan; Baek, Seung-Hoon; Lee, Young-Kyun; Koo, Kyung-Hoi | Seoul Natl Univ, Dept Orthopaed Surg, Bundang Hosp, Seongnam, South Korea; Seoul Bumin Hosp, Dept Orthopaed Surg, Seoul, South Korea; Nowon Eulji Med Ctr, Dept Orthopaed Surg, Seoul, South Korea; Konkuk Univ, Dept Orthopaed Surg, Sch Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Orthopaed Surg, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, Daegu, South Korea | Lee, Young-Kyun/D-6175-2012; Koo, Kyung-Hoi/D-7053-2012; Kim, Tae/C-1272-2009 | 57210893279; 59157724700; 57198436424; 59783202600; 55898554400; 56232924900; 15044971000; 23488849400 | ykleemd@gmail.com; | BMC MUSCULOSKELETAL DISORDERS | BMC MUSCULOSKEL DIS | 1471-2474 | 24 | 1 | SCIE | ORTHOPEDICS;RHEUMATOLOGY | 2023 | 2.2 | 30.5 | 1.13 | 2025-06-25 | 5 | 5 | Registry study; Hip fracture; Osteoporotic fracture; Fracture liaison service; Second fracture | ATYPICAL FEMORAL FRACTURES; INTERTROCHANTERIC FRACTURES; FEMUR FRACTURES; RISK; ARTHROPLASTY; FIXATION; NAIL; DIAPHYSEAL; MANAGEMENT; MORTALITY | Fracture liaison service; Hip fracture; Osteoporotic fracture; Registry study; Second fracture | Adult; Cohort Studies; Hand Strength; Hip Fractures; Humans; Longitudinal Studies; Osteoporotic Fractures; Prospective Studies; Registries; Republic of Korea; adult; age distribution; aged; arthroplasty; Article; body build; bone turnover; clinical research; cohort analysis; comparative study; dual energy X ray absorptiometry; female; femoral neck fracture; femur intertrochanteric fracture; femur subtrochanteric fracture; follow up; fragility fracture; grip strength; hip fracture; hospitalization; human; incidence; internet access; laboratory test; longitudinal study; major clinical study; male; medical information; mortality; nutritional assessment; observational study; osteosynthesis; prospective study; proximal femur fracture; radiological procedures; reoperation; risk factor; South Korea; clinical trial; diagnostic imaging; fragility fracture; hand strength; hip fracture; multicenter study; register | English | 2023 | 2023-06-02 | 10.1186/s12891-023-06546-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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