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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Durable Soft Mold for Imprinting of High-Adhesive Resin | A variety of polymer resins have been used to fabricate micro/nano structures via imprint lithography. In addition, with an interest in productivity, there is an increasing demand for the study of the process of easily demolding a cured resin from a mold for continuous fabrication of micro/nanostructures applying imprint lithography to the roll-type equipment. Among these polymer resins, Norland optical adhesive (NOA) in particular is widely used to fabricate micro/nano structure-based functional surfaces because of its shape memory characteristics, biocompatibility, and great optical characteristics. However, the cured NOA is originally used as an epoxy-based adhesive with its high adhesion. NOA has many advantages as a UV-curable adhesive, but as a resin in the imprint process, such adhesion brings a limitation. This high adhesion of cured NOA causes defects in the mold during the demolding process, so it is difficult to apply it to the continuous fabrication process. Here, we present a durable polyurethane acrylate (PUA) soft mold capable of clean demolding of an epoxy-based polymer resin having high adhesion by depositing metal on a surface. Au and Ni were deposited to a thickness of 100 A by using an E-beam evaporator. To verify the surface characteristics, each metal-deposited soft mold was compared with the previously used soft mold by measuring the contact angle and calculating surface energy. To test a performance of our soft mold, we imprinted nanoline pattern with NOA as a resin using metal-deposited soft mold in roll to roll (R2R) process for more than 240 replications for 90 min of operation time. It is expected that this study can be used for mass production of pattern with epoxy-based patterns required in many fields. | Lee, Jihoon; Lee, Sung Ho; Kwak, Moon Kyu | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Univ Michigan, Elect Elect & Comp Sci, Ann Arbor, MI 48105 USA | Kwak, Moon/AGQ-6058-2022 | 59448671600; 56195582600; 57203947984 | l2ji@knu.ac.kr;sunghol@umich.edu;mkkwak@knu.ac.kr; | COATINGS | COATINGS | 2079-6412 | 11 | 2 | SCIE | MATERIALS SCIENCE, COATINGS & FILMS;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2021 | 3.236 | 40.7 | 0.21 | 2025-07-30 | 3 | 3 | metal deposition; imprinting; soft mold; epoxy-based resin; continuous process | Continuous process; Epoxy-based resin; Imprinting; Metal deposition; Soft mold | English | 2021 | 2021-02 | 10.3390/coatings11020137 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Genome-Wide Identification and Expression Profiling of the PDI Gene Family Reveals Their Probable Involvement in Abiotic Stress Tolerance in Tomato (Solanum lycopersicum L.) | Protein disulfide isomerases (PDI) and PDI-like proteins catalyze the formation and isomerization of protein disulfide bonds in the endoplasmic reticulum and prevent the buildup of misfolded proteins under abiotic stress conditions. In the present study, we conducted the first comprehensive genome-wide exploration of the PDI gene family in tomato (Solanum lycopersicum L.). We identified 19 tomato PDI genes that were unevenly distributed on 8 of the 12 tomato chromosomes, with segmental duplications detected for 3 paralogous gene pairs. Expression profiling of the PDI genes revealed that most of them were differentially expressed across different organs and developmental stages of the fruit. Furthermore, most of the PDI genes were highly induced by heat, salt, and abscisic acid (ABA) treatments, while relatively few of the genes were induced by cold and nutrient and water deficit (NWD) stresses. The predominant expression of SlPDI1-1, SlPDI1-3, SlPDI1-4, SlPDI2-1, SlPDI4-1, and SlPDI5-1 in response to abiotic stress and ABA treatment suggested they play regulatory roles in abiotic stress tolerance in tomato in an ABA-dependent manner. Our results provide new insight into the structure and function of PDI genes and will be helpful for the selection of candidate genes involved in fruit development and abiotic stress tolerance in tomato. | Wai, Antt Htet; Waseem, Muhammad; Khan, A. B. M. Mahbub Morshed; Nath, Ujjal Kumar; Lee, Do Jin; Kim, Sang Tae; Kim, Chang Kil; Chung, Mi Young | Sunchon Natl Univ, Dept Agr Educ, 413 Jungangno, Sunchon 540950, Jeonnam, South Korea; Univ Mandalay, Dept Bot, Mandalay 05032, Myanmar; South China Agr Univ, Coll Hort, Guangzhou 510640, Peoples R China; Patuakhali Sci & Technol Univ, Dept Agr Bot, Fac Agr, Patuakhali 8602, Bangladesh; Bangladesh Agr Univ, Dept Genet & Plant Breeding, Mymensingh 2202, Bangladesh; Catholic Univ Korea, Dept Med & Biol Sci, Bucheon 14662, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Hort, Daegu 41566, South Korea | Kim, Sang-Tae/U-9457-2018; WASEEM, MUHAMMAD/K-9284-2019; Wai, Antt/AAG-9099-2021; Waseem, Muhammad/C-8001-2015; Kim, Sang-Tae/X-8917-2019 | 57196010294; 57203320375; 57221311065; 56460413300; 7406659787; 57202352361; 7409880701; 24821361600 | antthtetwai@mu.edu.mm;m.waseem.botanist@gmail.com;morshed@pstu.ac.bd;ujjalnath@gmail.com;djlee@scnu.ac.kr;stkim@catholic.ac.kr;ckkim@knu.ac.kr;queen@sunchon.ac.kr; | GENES | GENES-BASEL | 2073-4425 | 12 | 1 | SCIE | GENETICS & HEREDITY | 2021 | 4.141 | 40.9 | 1.24 | 2025-07-30 | 17 | 17 | Solanum lycopersicum; protein disulfide isomerases; genome-wide analysis; gene expression; abiotic stress; fruit development | PROTEIN-DISULFIDE-ISOMERASE; MOLECULAR EVOLUTION; RESPONSIVE GENES; ARABIDOPSIS; PLANT; BINDING; SEQUENCE | Abiotic stress; Fruit development; Gene expres-sion; Genome-wide analysis; Protein disulfide isomerases; Solanum lycopersicum | Abscisic Acid; Adaptation, Physiological; Fruit; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Lycopersicon esculentum; Multigene Family; Plant Proteins; Protein Disulfide-Isomerases; Stress, Physiological; abscisic acid; protein disulfide isomerase; plant protein; protein disulfide isomerase; abiotic stress; Article; chromosome duplication; cold stress; controlled study; developmental stage; fruit development; gene duplication; gene expression; gene expression level; gene expression profiling; gene function; gene identification; genetic variability; genome-wide association study; nonhuman; PDI gene; phylogeny; physiological stress; plant chromosome; plant gene; promoter region; quantitative analysis; real time polymerase chain reaction; RNA isolation; sequence alignment; SlPDI1 1 gene; SlPDI1 3 gene; SlPDI1 4 gene; SlPDI2 1 gene; SlPDI4 1 gene; SlPDI5 1 gene; tomato; water deficit; adaptation; fruit; gene expression profiling; gene expression regulation; genetics; growth, development and aging; metabolism; multigene family; physiological stress; physiology | English | 2021 | 2021-01 | 10.3390/genes12010023 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | In Vitro Antiplatelet Activity of Mulberroside C through the Up-Regulation of Cyclic Nucleotide Signaling Pathways and Down-Regulation of Phosphoproteins | Physiological agonists trigger signaling cascades, called "inside-out signaling", and activated platelets facilitate adhesion, shape change, granule release, and structural change of glycoprotein IIb/IIIa (alpha IIb/beta 3). Activated alpha IIb/beta 3 interacts with fibrinogen and begins second signaling cascades called "outside-in signaling". These two signaling pathways can lead to hemostasis or thrombosis. Thrombosis can occur in arterial and venous blood vessels and is a major medical problem. Platelet-mediated thrombosis is a major cause of cardiovascular disease (CVD). Therefore, controlling platelet activity is important for platelet-mediated thrombosis and cardiovascular diseases. In this study, focus on Morus Alba Linn, a popular medicinal plant, to inhibit the function of platelets and found the containing component mulberroside C. We examine the effect of mulberroside C on the regulation of phosphoproteins, platelet-activating factors, and binding molecules. Agonist-induced human platelet aggregation is dose-dependently inhibited by mulberroside C without cytotoxicity, and it decreased Ca2+ mobilization and p-selectin expression through the upregulation of inositol 1, 4, 5-triphosphate receptor I (Ser(1756)), and downregulation of extracellular signal-regulated kinase (ERK). In addition, mulberroside C inhibited thromboxane A(2) production, fibrinogen binding, and clot retraction. Our results show antiplatelet effects and antithrombus formation of mulberroside C in human platelets. Thus, we confirm that mulberroside C could be a potential phytochemical for the prevention of thrombosis-mediated CVDs. | Kwon, Hyuk-Woo; Lee, Dong-Ha; Rhee, Man Hee; Shin, Jung-Hae | Far East Univ, Dept Biomed Lab Sci, Eumseong 27601, South Korea; Namseoul Univ, Dept Biomed Lab Sci, Cheonan 31020, South Korea; Namseoul Univ, Mol Diagnost Res Inst, Cheonan 31020, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu 41566, South Korea; Catholic Kwandong Univ, Dept Biomed Lab Sci, Kangnung 25601, South Korea | ; Rhee, Man/O-5705-2016 | 55200547400; 57208891222; 57211035357; 56244056800 | kwonhw@kdu.ac.kr;dhlee@nsu.ac.kr;rheemh@knu.ac.kr;mlsjshin@cku.ac.kr; | GENES | GENES-BASEL | 2073-4425 | 12 | 7 | SCIE | GENETICS & HEREDITY | 2021 | 4.141 | 40.9 | 0.31 | 2025-07-30 | 5 | 5 | mulberroside C; intracellular calcium; glycoprotein IIb; IIIa; granule secretion; clot retraction | PHOSPHORYLATION; ACTIVATION; PLATELETS; THROMBIN; COLLAGEN | Clot retraction; Glycoprotein IIb/IIIa; Granule secretion; Intracellular calcium; Mulberroside C | Benzopyrans; Blood Platelets; Gene Expression Regulation; Humans; In Vitro Techniques; Nucleotides, Cyclic; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; actin; CD36 antigen; collagen type 1; cyclic nucleotide; dimethyl sulfoxide; F actin; fibrinogen; fibrinogen receptor; immunoglobulin enhancer binding protein; inositol 1,4,5 trisphosphate receptor; lactate dehydrogenase; mitogen activated protein kinase 1; mulberroside A; phosphoprotein; phytochemical; reactive oxygen metabolite; selectin (glycoprotein); serotonin; thromboxane A2; thromboxane B2; unclassified drug; antithrombocytic agent; benzopyran derivative; cyclic nucleotide; mulberroside C; phosphoprotein; antiplatelet activity; apoptosis; Article; cAMP signaling; controlled study; cytokine production; cytotoxicity; down regulation; drug efficacy; enzyme activity; enzyme immunoassay; enzyme linked immunosorbent assay; fibrin clot; flow cytometry; human; human cell; IC50; immunoblotting; neurite outgrowth; nonhuman; phytochemistry; protein expression; protein phosphorylation; signal transduction; thrombocyte activation; thrombocyte aggregation; thrombocyte function; thrombocyte rich plasma; upregulation; drug effect; gene expression regulation; genetics; in vitro study; metabolism; pathology; thrombocyte; thrombocyte aggregation | English | 2021 | 2021-07 | 10.3390/genes12071024 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Insights into the Transcriptional Regulation of Branching Hormonal Signaling Pathways Genes under Drought Stress in Arabidopsis | A large number of hormonal biosynthetic or signaling pathways genes controlling shoot branching are widely known for their roles in regulating plant growth and development, operating in synergetic or antagonistic manner. However, their involvement in abiotic stress response mechanism remains unexplored. Initially, we performed an in silico analysis to identify potential transcription binding sites for the basic leucine zipper 62 transcription factor (bZIP62 TF) in the target branching related genes. The results revealed the presence of cis-regulatory elements specific to two bZIP TFs, AtbZIP18 and AtbZIP69, rather than AtbZIP62. Interestingly, these bZIP TFs were previously proposed to be negatively regulated by the AtbZIP62 TF under salinity in Arabidopsis. Therefore, we investigated the transcriptional regulation of more axillary branching (MAX, strigolactone), PIN-FORMED (PINs, auxin carriers), gibberellic acid (GA)-biosynthetic genes as well as isopentenyltransferase (IPT, cytokinin biosynthesis pathway) genes in response to drought stress in Arabidopsis Col-0 wild type. In addition, in the perspective of exploring the transcriptional interplay of the selected genes with the AtbZIP62, we measured their expression by qPCR in the atbzip62 (lacking the AtbZIP62 gene) background under the same conditions. Our findings revealed that the expression of AtMAX2, AtMAX3, and AtMAX4 was differentially regulated by drought stress between the atbzip62 and Col-0 wild type, but not AtMAX1. Similarly, the transcripts accumulation of AtPIN3 and AtPIN7 (known as auxin efflux carriers), and that of the AtAXR1 showed similar regulation patterns in atbzip62. However, AtPIN1 expression was downregulated in Col-0, but no change was observed in atbzip62. Furthermore, AtIPT5 and AtIPT7 exhibited a differential transcripts accumulation pattern in atbzip62 and Col-0 wild type (WT). In the same way, the expression of the GA biosynthetic genes AtGA2ox1 and AtGA20ox2, and that of AtRGA1 were differentially regulated in atbzip62 compared to the Col-0. Meanwhile, AtGA2ox1 showed a similar expression pattern with Col-0. Therefore, all results suggest PIN, MAX, IPT, and GA-biosynthetic genes, which are differentially regulated by AtbZIP62 transcription factor, as emerging candidate genes that could be involved in drought stress response mechanism in Arabidopsis. | Rolly, Nkulu Kabange; Mun, Bong-Gyu; Yun, Byung-Wook | Kyungpook Natl Univ, Sch Appl Biosci, Lab Plant Funct Genom, Daegu 41566, South Korea; RDA, Natl Inst Crop Sci, Dept Southern Area Crop Sci, Miryang 50424, South Korea; Minist Agr, SENASEM, Natl Seed Serv, Natl Lab Seed Testing, 904KIN1, Kinshasa, DEM REP CONGO | ; Mun, BongGyu/GYD-6010-2022; KABANGE, NKULU/AAQ-9425-2020 | 57202031236; 57147241300; 8245123600 | rolly.kabange@gmail.com;mun0301@naver.com;bwyun@knu.ac.kr; | GENES | GENES-BASEL | 2073-4425 | 12 | 2 | SCIE | GENETICS & HEREDITY | 2021 | 4.141 | 40.9 | 0.62 | 2025-07-30 | 11 | 10 | PIN-FORMED; more axillary branching; isopentenyltransferase; gibberellic acid; AtbZIP62; transcription factor; drought tolerance; Arabidopsis | GIBBERELLIN 20-OXIDASE; LIPID-PEROXIDATION; AUXIN TRANSPORT; CYTOKININ; ENCODES; EXPRESSION; PLANTS; GROWTH; RICE; IDENTIFICATION | Arabidopsis; At-bZIP62; Drought tolerance; Gibberellic acid; Isopentenyltransferase; More axillary branching; PIN-FORMED; Transcription factor | Arabidopsis; Arabidopsis Proteins; Droughts; Gene Expression Regulation, Plant; Phenotype; Plant Development; Plant Growth Regulators; Signal Transduction; Stress, Physiological; auxin; gibberellic acid; isopentenyltransferase; phytohormone; plant protein; strigolactone; unclassified drug; Arabidopsis protein; phytohormone; Arabidopsis thaliana; Article; AtAXR1 gene; AtbZIP18 gene; AtbZIP62 gene; AtbZIP69 gene; AtGA2ox1 gene; AtIPT5 gene; AtIPT7 gene; AtMAX2 gene; AtMAX3 gene; AtMAX4 gene; AtPIN1 gene; AtPIN3 gene; AtPIN7 gene; AtRGA1 gene; computer model; controlled study; down regulation; drought stress; gene expression; nonhuman; plant gene; plant genetics; polymerase chain reaction; signal transduction; transcription regulation; upregulation; Arabidopsis; drought; gene expression regulation; genetics; metabolism; phenotype; physiological stress; physiology; plant development | English | 2021 | 2021-02 | 10.3390/genes12020298 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Microarray Genotyping Identifies New Loci Associated with Dementia in Parkinson's Disease | Dementia is one of the most disabling nonmotor symptoms of Parkinson's disease (PD). However, the risk factors contributing to its development remain unclear. To investigate genetic variants associated with dementia in PD, we performed microarray genotyping based on a customized platform utilizing variants identified in previous genetic studies. Microarray genotyping was performed in 313 PD patients with dementia, 321 PD patients without dementia, and 635 healthy controls. The primary analysis was performed using a multiple logistic regression model adjusted for age and sex. SNCA single nucleotide polymorphism (SNP) rs11931074 was determined to be most significantly associated with PD (odds ratio = 0.66, 95% confidence interval = 0.56-0.78, p = 7.75 x 10(-7)). In the analysis performed for patients with PD only, MUL1 SNP rs3738128 (odds ratio = 2.52, 95% confidence interval = 1.68-3.79, p = 8.75 x 10(-6)) was found to be most significantly associated with dementia in PD. SNPs in ZHX2 and ERP29 were also associated with dementia in PD. This microarray genomic study identified new loci of MUL1 associated with dementia in PD, suggesting an essential role of mitochondrial dysfunction in the development of dementia in patients with PD. | Jo, Sungyang; Park, Kye Won; Hwang, Yun Su; Lee, Seung Hyun; Ryu, Ho-Sung; Chung, Sun Ju | Univ Ulsan, Dept Neurol, Asan Med Ctr, Coll Med, Seoul 05505, South Korea; Eulji Univ, Dept Neurol, Uijeongbu Eulji Med Ctr, Sch Med, Uijeongbu Si 11759, Gyeonggi Do, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol, Daegu 41944, South Korea | 57204969008; 57194448346; 57219161130; 57219164267; 57014206500; 56882955600 | sungyangjo@gmail.com;karabach88@gmail.com;ghkddbstn1@naver.com;doors327@naver.com;ryuhosung138@gmail.com;sjchung@amc.seoul.kr; | GENES | GENES-BASEL | 2073-4425 | 12 | 12 | SCIE | GENETICS & HEREDITY | 2021 | 4.141 | 40.9 | 0.46 | 2025-07-30 | 6 | 8 | genome-wide association study; Parkinson's disease; dementia; cognition | GENOME-WIDE ASSOCIATION; LEWY BODIES; RISK LOCI; METAANALYSIS; VARIANTS | Cognition; Dementia; Genome-wide association study; Parkinson’s disease | Aged; Aged, 80 and over; Dementia; Female; Genetic Predisposition to Disease; Genotype; Heat-Shock Proteins; Humans; Male; Middle Aged; Odds Ratio; Parkinson Disease; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors; Transcription Factors; heat shock protein; transcription factor; adult; age; aged; Article; cognition; confidence interval; controlled study; dementia; ERP29 gene; female; gene; gene locus; genetic association; genetic variability; genome-wide association study; genomics; genotyping; human; major clinical study; male; microarray analysis; MUL1 gene; multivariate logistic regression analysis; odds ratio; Parkinson disease; pathogenesis; sex; single nucleotide polymorphism; SNCA gene; ZHX2 gene; dementia; genetic predisposition; genetics; genotype; middle aged; Parkinson disease; prospective study; risk factor; very elderly | English | 2021 | 2021-12 | 10.3390/genes12121975 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | MicroRNA 34a-AXL Axis Regulates Vasculogenic Mimicry Formation in Breast Cancer Cells | Targeting the tumor vasculature is an attractive strategy for cancer treatment. However, the tumor vasculature is heterogeneous, and the mechanisms involved in the neovascularization of tumors are highly complex. Vasculogenic mimicry (VM) refers to the formation of vessel-like structures by tumor cells, which can contribute to tumor neovascularization, and is closely related to metastasis and a poor prognosis. Here, we report a novel function of AXL receptor tyrosine kinase (AXL) in the regulation of VM formation in breast cancer cells. MDA-MB-231 cells exhibited VM formation on Matrigel cultures, whereas MCF-7 cells did not. Moreover, AXL expression was positively correlated with VM formation. Pharmacological inhibition or AXL knockdown strongly suppressed VM formation in MDA-MB-231 cells, whereas the overexpression of AXL in MCF-7 cells promoted VM formation. In addition, AXL knockdown regulated epithelial-mesenchymal transition (EMT) features, increasing cell invasion and migration in MDA-MB-231 cells. Finally, the overexpression of microRNA-34a (miR-34a), which is a well-described EMT-inhibiting miRNA and targets AXL, inhibited VM formation, migration, and invasion in MDA-MB 231 cells. These results identify a miR-34a-AXL axis that is critical for the regulation of VM formation and may serve as a therapeutic target to inhibit tumor neovascularization. | Lim, Dansaem; Cho, Jin Gu; Yun, Eunsik; Lee, Aram; Ryu, Hong-Yeoul; Lee, Young Joo; Yoon, Sukjoon; Chang, Woochul; Lee, Myeong-Sok; Kwon, Byung Su; Kim, Jongmin | Sookmyung Womens Univ, Div Biol Sci, Seoul 04310, South Korea; Sookmyung Womens Univ, Res Inst Womens Hlth, Seoul 04310, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 KNU Creat BioRes Grp 4, Coll Natl Sci, Daegu 41566, South Korea; Kyung Hee Univ, Med Ctr, Dept Obstet & Gynecol, Seoul 02447 23, South Korea; Pusan Natl Univ, Dept Biol Educ, Coll Educ, Busan 46241, South Korea | ; Kim, Jong-Min/J-5435-2012; Cho, JinGu/GQB-2969-2022; Lee, YoungJoo/ABB-5314-2021 | 57217351306; 55439966300; 57207311722; 56242227000; 55889917800; 57203798713; 8559782700; 12797539700; 57204796942; 57190952625; 37112415400 | lds05101@hanmail.net;jgcho84@gmail.com;yes951212@naver.com;aram0918@sookmyung.ac.kr;rhr4757@knu.ac.kr;intro4med@naver.com;yoonsj@sookmyung.ac.kr;wchang1975@pusan.ac.kr;mslee@sookmyung.ac.kr;kbsgyonco@naver.com;jkim@sookmyung.ac.kr; | GENES | GENES-BASEL | 2073-4425 | 12 | 1 | SCIE | GENETICS & HEREDITY | 2021 | 4.141 | 40.9 | 1.32 | 2025-07-30 | 18 | 19 | breast cancer; vasculogenic mimicry; epithelial– mesenchymal transition; AXL; miR-34a | AXL; Breast cancer; Epithelial–mesenchymal transition; MiR-34a; Vasculogenic mimicry | Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Neoplasm Invasiveness; Neovascularization, Pathologic; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; AXL protein; matrigel; microRNA 34a; regulator protein; unclassified drug; axl receptor tyrosine kinase; microRNA; MIRN34 microRNA, human; oncoprotein; protein tyrosine kinase; Article; breast cancer cell line; cancer cell culture; cell invasion; cell migration; controlled study; epithelial mesenchymal transition; gene overexpression; human; human cell; neovascularization (pathology); protein expression; protein function; tumor vascularization; breast; breast tumor; cell motion; female; gene expression regulation; genetics; metabolism; pathology; tumor cell line; tumor invasion; vascularization | English | 2021 | 2021-01 | 10.3390/genes12010009 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Predictive Value of Circulating miRNAs in Lymph Node Metastasis for Colon Cancer | (1) Background: Lymph node (LN) status is an indubitable prognostic factor for survival among colon cancer patients. MicroRNAs (miRNAs) have been implicated in the development and progression of many cancers and are potential biomarkers for cancer diagnosis and prognosis. Therefore, we validated candidate biomarkers using circulating miRNAs by analyzing the plasma miRNA concentrations from patients with colon cancer to predict LN metastasis. (2) Methods: This study included 79 blood samples from patients diagnosed with colon cancer. The NanoString assay was used for screening, and TaqMan miRNA assays for quantitative real-time polymerase chain reaction (RT-PCR) test was used for validation. In a discovery set, we compared the expression of 800 circulating miRNAs in 24 samples (stage 0/I/IIA versus IIIB/IIIC). For validation, a total 79 samples were tested using quantitative RT-PCR. (3) Results: In the discovery set, 10 candidate circulating miRNAs were detected (4 up-regulated miRNAs: miR-323a-3p, miR-382-5p, miR-29a-3p, and miR-376a-3p; 6 down-regulated miRNAs: miR-26a-5p, let-7g-5p, miR-15b-5p, miR-142-3p, miR-374a-5p, and let-7b-5p). In the validation set, higher expression of three circulating miRNAs (miR-323a-3p, miR-382-5p, and miR-376a-3p) was significantly associated with LN metastasis (p = 0.0063, 0.0107, and 0.0022). (4) Conclusions: High expression of circulating miR-323a-3p, miR-382-5p, and miR-376a-3p was significantly associated with LN metastasis in colon cancer patients. These miRNAs could be circulating biomarker candidates that predict the presence of LN metastasis. | Lee, In Hee; Kim, Gyeonghwa; Kwak, Sang Gyu; Baek, Dong Won; Kang, Byung Woog; Kim, Hye Jin; Park, Su Yeon; Park, Jun Seok; Choi, Gyu-Seog; Hur, Keun; Kim, Jong Gwang | Daegu Catholic Univ, Sch Med, Dept Internal Med, Div Hematol Oncol, Daegu 42112, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41404, South Korea; Daegu Catholic Univ, Sch Med, Dept Med Stat, Daegu 42112, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Canc Res Inst, Dept Oncol Hematol,Sch Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Canc Res Inst, Dept Surg,Sch Med, Daegu 41404, South Korea | ; Kwak, Sang Gyu/AAG-4341-2021; Hur, Keun/G-9513-2011; Kim, Gyeonghwa/AAQ-6424-2021; Kim, Hye/W-1059-2019; Park, Joonhong/AAZ-9885-2020 | 56390538200; 57195957884; 56645812600; 57191874272; 28567838500; 57204567554; 57203275898; 35226761100; 8058759100; 8861888000; 59501049300 | cakey83@hanmail.net;med.aurora1106@gamil.com;sanggyu39@naver.com;baekdw83@gamil.com;bwkang@knu.ac.kr;chocogom@hanmail.net;psy-flower@hanmail.net;caumed5@hanmail.net;kyuschoi@knu.ac.kr;keunhur@knu.ac.kr;jkk21c@knu.ac.kr; | GENES | GENES-BASEL | 2073-4425 | 12 | 2 | SCIE | GENETICS & HEREDITY | 2021 | 4.141 | 40.9 | 0.7 | 2025-07-30 | 13 | 10 | microRNA; biomarker; circulating microRNAs; lymph node metastasis; colon | Biomarker; Circulating microRNAs; Colon; Lymph node metastasis; MicroRNA | Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Circulating MicroRNA; Colonic Neoplasms; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Prognosis; ROC Curve; Survival Analysis; circulating microRNA; let-7g 5p; microRNA 142 3p; microRNA 15b 5p; microRNA 26a 5p; microRNA 29a 3p; microRNA 323a 3p; microRNA 374a 5p; microRNA 376a 3p; microRNA 382 5p; microRNA 7b 5p; unclassified drug; circulating microRNA; tumor marker; adult; aged; Article; blood sampling; cancer prognosis; cancer staging; cancer survival; colon cancer; controlled study; disease marker; down regulation; female; gene expression; human; human cell; lymph node metastasis; major clinical study; male; predictive value; real time polymerase chain reaction; receiver operating characteristic; scoring system; survival analysis; survival rate; upregulation; validity; very elderly; colon tumor; gene expression profiling; gene expression regulation; genetics; lymph node metastasis; middle aged; mortality; prognosis | English | 2021 | 2021-02 | 10.3390/genes12020176 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Production of Membrane Vesicles in Listeria monocytogenes Cultured with or without Sub-Inhibitory Concentrations of Antibiotics and Their Innate Immune Responses In Vitro | Listeriosis is a food-borne illness caused by Listeria monocytogenes. Ampicillin (AMP) alone or in combination with gentamicin (GEN) is the first-line treatment option. Membrane vesicle (MV) production in L. monocytogenes under antibiotic stress conditions and pathologic roles of these MVs in hosts have not been reported yet. Thus, the aim of this study was to investigate the production of MVs in L. monocytogenes cultured with sub-minimum inhibitory concentrations (MICs) of AMP, GEN, or trimethoprim/sulfamethoxazole (SXT) and determine pathologic effects of these MVs in colon epithelial Caco-2 cells. L. monocytogenes cultured in tryptic soy broth with 1/2 MIC of AMP, GEN, or SXT produced 6.0, 2.9, or 1.5 times more MV particles, respectively, than bacteria cultured without antibiotics. MVs from L. monocytogenes cultured with AMP (MVAMP), GEN (MVGEN), or SXT (MVSXT) were more cytotoxic to Caco-2 cell than MVs obtained from cultivation without antibiotics (MVTSB). MVAMP induced more expression of tumor necrosis factor (TNF)-alpha gene than MVTSB, MVGEN and MVSXT, whereas MVTSB induced more expression of interleukin (IL)-1 beta and IL-8 genes than other MVs. Expression of pro-inflammatory cytokine genes by L. monocytogenes MVs was significantly inhibited by proteinase K treatment of MVs. In conclusion, antibiotic stress can trigger the biogenesis of MVs in L. monocytogenes and MVs produced by L. monocytogenes exposed to sub-MIC of AMP can induce strong pro-inflammatory responses by expressing TNF-alpha gene in host cells, which may contribute to the pathology of listeriosis. | Woo, Jung-Hwa; Kim, Shukho; Lee, Taewon; Lee, Je-Chul; Shin, Ji-Hyun | Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea; Korea Univ, Dept Appl Math, Coll Sci & Technol, Sejong 30019, South Korea; Korea Univ, Inst Sci & Technol, Coll Sci & Technol, Sejong 30019, South Korea | ; Kim, Shukho/AGG-1087-2022 | 57211502461; 24341187900; 55501330600; 25930392000; 52464611600 | dasomi999@naver.com;shukhokim@knu.ac.kr;taewon70@korea.ac.kr;leejc@knu.ac.kr;jhshin@korea.ac.kr; | GENES | GENES-BASEL | 2073-4425 | 12 | 3 | SCIE | GENETICS & HEREDITY | 2021 | 4.141 | 40.9 | 0.54 | 2025-07-30 | 11 | 11 | Listeria monocytogenes; membrane vesicles; innate immune response; antibiotics | Antibiotics; Innate immune response; Listeria monocytogenes; Membrane vesicles | Anti-Bacterial Agents; Bacterial Proteins; Caco-2 Cells; Cell Line, Tumor; Cytokines; Humans; Immunity, Innate; Listeria monocytogenes; Listeriosis; Microbial Sensitivity Tests; Virulence Factors; ampicillin; cotrimoxazole; gentamicin; interleukin 1beta; interleukin 8; tumor necrosis factor; antiinfective agent; bacterial protein; cytokine; virulence factor; antibiotic sensitivity; Article; bacterial strain; bacterium culture; bacterium isolation; Caco-2 cell line; cell culture; cell mediated cytotoxicity; controlled study; drug effect; gene expression; gene expression level; human; human cell; IL 1beta gene; IL 8 gene; in vitro study; innate immunity; Listeria monocytogenes; membrane vesicle; minimum inhibitory concentration; MTT assay; nonhuman; particle size; quantitative analysis; real time polymerase chain reaction; TNF alpha gene; drug effect; immunology; innate immunity; listeriosis; microbial sensitivity test; procedures; tumor cell line | English | 2021 | 2021-03 | 10.3390/genes12030415 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Screening and Genetic Network Analysis of Genes Involved in Freezing and Thawing Resistance in DaMDHAR-Expressing Saccharomyces cerevisiae Using Gene Expression Profiling | The cryoprotection of cell activity is a key determinant in frozen-dough technology. Although several factors that contribute to freezing tolerance have been reported, the mechanism underlying the manner in which yeast cells respond to freezing and thawing (FT) stress is not well established. Therefore, the present study demonstrated the relationship between DaMDHAR encoding monodehydroascorbate reductase from Antarctic hairgrass Deschampsia antarctica and stress tolerance to repeated FT cycles (FT2) in transgenic yeast Saccharomyces cerevisiae. DaMDHAR-expressing yeast (DM) cells identified by immunoblotting analysis showed high tolerance to FT stress conditions, thereby causing lower damage for yeast cells than wild-type (WT) cells with empty vector alone. To detect FT2 tolerance-associated genes, 3 '-quant RNA sequencing was employed using mRNA isolated from DM and WT cells exposed to FT (FT2) conditions. Approximately 332 genes showed >= 2-fold changes in DM cells and were classified into various groups according to their gene expression. The expressions of the changed genes were further confirmed using western blot analysis and biochemical assay. The upregulated expression of 197 genes was associated with pentose phosphate pathway, NADP metabolic process, metal ion homeostasis, sulfate assimilation, beta-alanine metabolism, glycerol synthesis, and integral component of mitochondrial and plasma membrane (PM) in DM cells under FT2 stress, whereas the expression of the remaining 135 genes was partially related to protein processing, selenocompound metabolism, cell cycle arrest, oxidative phosphorylation, and alpha-glucoside transport under the same condition. With regard to transcription factors in DM cells, MSN4 and CIN5 were activated, but MSN2 and MGA1 were not. Regarding antioxidant systems and protein kinases in DM cells under FT stress, CTT1, GTO, GEX1, and YOL024W were upregulated, whereas AIF1, COX2, and TRX3 were not. Gene activation represented by transcription factors and enzymatic antioxidants appears to be associated with FT2-stress tolerance in transgenic yeast cells. RCK1, MET14, and SIP18, but not YPK2, have been known to be involved in the protein kinase-mediated signalling pathway and glycogen synthesis. Moreover, SPI18 and HSP12 encoding hydrophilin in the PM were detected. Therefore, it was concluded that the genetic network via the change of gene expression levels of multiple genes contributing to the stabilization and functionality of the mitochondria and PM, not of a single gene, might be the crucial determinant for FT tolerance in DaMDAHR-expressing transgenic yeast. These findings provide a foundation for elucidating the DaMDHAR-dependent molecular mechanism of the complex functional resistance in the cellular response to FT stress. | Kim, Il-Sup; Choi, Woong; Son, Jonghyeon; Lee, Jun Hyuck; Lee, Hyoungseok; Lee, Jungeun; Shin, Seung Chul; Kim, Han-Woo | Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu 41566, South Korea; Korea Polar Res Inst, Incheon 21990, South Korea; Univ Sci & Technol, Dept Polar Sci, Incheon 21990, South Korea | ; Shin, Seung Chul/LIA-8245-2024; Choi, Woong/AAD-9084-2019 | 55477678200; 57211508168; 55881098100; 57214247889; 57216148355; 57206732355; 55804630100; 22985057300 | 92kis@hanmail.net;woong@kopri.re.kr;jonghyeon_son@kopri.re.kr;junhyucklee@kopri.re.kr;soulaid@kopri.re.kr;jelee@kopri.re.kr;ssc@kopri.re.kr;hwkim@kopri.re.kr; | GENES | GENES-BASEL | 2073-4425 | 12 | 2 | SCIE | GENETICS & HEREDITY | 2021 | 4.141 | 40.9 | 0.39 | 2025-07-30 | 3 | 6 | Antarctic plant; Deschampsia antarctica; monodehydroascorbate reductase; freezing and thawing; gene expression profiling; transgenic yeast | Antarctic plant; Deschampsia antarctica; Freezing and thawing; Gene expression profiling; Monodehydroascorbate reductase; Transgenic yeast | Freezing; Gene Expression Regulation, Fungal; Gene Regulatory Networks; NADH, NADPH Oxidoreductases; Poaceae; Saccharomyces cerevisiae; Stress, Physiological; Transcription Factors; alanine; dehydroascorbic acid reductase; messenger RNA; monodehydroascorbate reductase; natural resistance associated macrophage protein 2; protein kinase; sulfate; transcription factor; unclassified drug; monodehydroascorbate reductase (NADH); oxidoreductase; transcription factor; 3' untranslated region; AIF1 gene; amino acid metabolism; amino acid synthesis; Article; biochemical analysis; cell cycle arrest; cell damage; cell membrane; CIN5 gene; controlled study; COX2 gene; CTT1 gene; DaMDHAR gene; Deschampsia antarctica; enzyme activity; freeze thawing; fungal gene; gene activation; gene expression level; gene expression profiling; genetic analysis; genetic screening; GEX1 gene; glycogen synthesis; grass; GTO gene; homeostasis; immunoblotting; MET14 gene; MGA1 gene; mitochondrion; MSN2 gene; MSN4 gene; nonhuman; oxidative phosphorylation; pentose phosphate cycle; physiological stress; protein processing; RCK1 gene; RNA isolation; RNA sequencing; Saccharomyces cerevisiae; signal transduction; SIP18 gene; TRX3 gene; upregulation; Western blotting; wild type; yeast cell; YOL024W gene; YPK2 gene; adverse event; enzymology; freezing; gene expression regulation; gene regulatory network; genetics; Poaceae | English | 2021 | 2021-02 | 10.3390/genes12020219 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Transcriptomic Analysis of Rice Plants Overexpressing PsGAPDH in Response to Salinity Stress | In plants, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a main enzyme in the glycolytic pathway. It plays an essential role in glycerolipid metabolism and response to various stresses. To examine the function of PsGAPDH (Pleurotus sajor-caju GAPDH) in response to abiotic stress, we generated transgenic rice plants with single-copy/intergenic/homozygous overexpression PsGAPDH (PsGAPDH-OX) and investigated their responses to salinity stress. Seedling growth and germination rates of PsGAPDH-OX were significantly increased under salt stress conditions compared to those of the wild type. To elucidate the role of PsGAPDH-OX in salt stress tolerance of rice, an Illumina HiSeq 2000 platform was used to analyze transcriptome profiles of leaves under salt stress. Analysis results of sequencing data showed that 1124 transcripts were differentially expressed. Using the list of differentially expressed genes (DEGs), functional enrichment analyses of DEGs such as Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were performed. KEGG pathway enrichment analysis revealed that unigenes exhibiting differential expression were involved in starch and sucrose metabolism. Interestingly, trehalose-6-phosphate synthase (TPS) genes, of which expression was enhanced by abiotic stress, showed a significant difference in PsGAPDH-OX. Findings of this study suggest that PsGAPDH plays a role in the adaptation of rice plants to salt stress. | Lim, Hyemin; Hwang, Hyunju; Kim, Taelim; Kim, Soyoung; Chung, Hoyong; Lee, Daewoo; Kim, Soorin; Park, Soochul; Cho, Woosuk; Ji, Hyeonso; Lee, Gangseob | Natl Inst Forest Sci, Dept Forest Bioresources, Suwon 16631, South Korea; Natl Marine Biodivers Inst Korea, Dept Appl Marine Bioresource Sci, Seocheon 33662, South Korea; Rural Dev Adm, Natl Inst Agr Sci, Jeonju 54874, South Korea; 3BIGS CO LTD, 156 Gwanggyo Ro, Suwon 16429, South Korea; Rural Dev Adm, Natl Inst Crop Sci, Suwon 16430, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | ; Kim, Soo Rin/X-2192-2019 | 16245024900; 57196458040; 56160159000; 57204760604; 57219361312; 7406665921; 36659584200; 57203251031; 57215232371; 7201738214; 25927158200 | supia1125@korea.kr;hjhwang@mabik.re.kr;ktlmi01@korea.kr;sykimflower@korea.kr;hychung@3bigs.com;dlee@korea.kr;soorinkim@knu.ac.kr;usdapark@korea.kr;phyto@korea.kr;jhs77@korea.kr;kangslee0227@gmail.com; | GENES | GENES-BASEL | 2073-4425 | 12 | 5 | SCIE | GENETICS & HEREDITY | 2021 | 4.141 | 40.9 | 1.01 | 2025-07-30 | 14 | 14 | glyceraldehyde-3-phosphate dehydrogenase; salt stress; tolerance; transcriptomic analysis; transgenic rice | ORYZA-SATIVA L.; GENE-EXPRESSION; SALT STRESS; TOLERANCE; DROUGHT; PHOTOSYNTHESIS; GROWTH; TISSUE; TOOL | Glyceraldehyde-3-phosphate dehydrogenase; Salt stress; Tolerance; Transcriptomic analy-sis; Transgenic rice | Gene Expression Regulation, Plant; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Oryza; Plant Leaves; Plant Proteins; Salt Stress; Transcriptome; Up-Regulation; glyceraldehyde 3 phosphate dehydrogenase; starch; sucrose; transcriptome; transferase; trehalose 6 phosphate synthase; unclassified drug; glyceraldehyde 3 phosphate dehydrogenase; plant protein; transcriptome; Article; carbohydrate metabolism; differential gene expression; gene function; gene ontology; gene overexpression; germination rate; homozygosity; nonhuman; plant gene; plant growth; plant leaf; plant response; PsGAPDH gene; rice; salt stress; salt tolerance; sucrose metabolism; TPS gene; transcriptomics; transgenic plant; wild type; gene expression regulation; genetics; metabolism; Oryza; upregulation | English | 2021 | 2021-05 | 10.3390/genes12050641 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Identification of Metabolic Phenotypes in Young Adults with Obesity by ¹H NMR Metabolomics of Blood Serum | (1) Since the obesity prevalence rate has been consistently increasing, it is necessary to find an effective way to prevent and treat it. Although progress is being made to reduce obesity in the young adult population, a better understanding of obesity-related metabolomics and related biochemical mechanisms is urgently needed for developing appropriate screening strategies. Therefore, the aim of this study is to identify the serum metabolic profile associated with young adult obesity and its metabolic phenotypes. (2) Methods: The serum metabolic profile of 30 obese and 30 normal-weight young adults was obtained using proton nuclear magnetic resonance spectroscopy (H-1 NMR). H-1 NMR spectra were integrated into 24 integration regions, which reflect relative metabolites, and were used as statistical variables. (3) Results: The obese group showed increased levels of lipids, glucose, glutamate, N-acetyl glycoprotein, alanine, lactate, 3 hydroxybutyrate and branch chain amino acid (BCAA), and decreased levels of choline as compared with the normal-weight group. Non-hyperlipidemia obese adults showed lower levels of lipids and lactate, glutamate, acetoacetate, N-acetyl glycoprotein, isoleucine, and higher levels of choline and glutamine, as compared with hyperlipidemic obese adults. (4) Conclusions: This study reveals valuable findings in the field of metabolomics and young adult obesity. We propose several serum biomarkers that distinguish between normal weight and obese adults, i.e., glutamine (higher in the normal group, p < 0.05), and lactate, BCAAs, acetoacetate and 3-hydroxybutyrate (higher in the obese group, p < 0.05). In addition, visceral fat and serum TG, glutamate, acetoacetate, N-acetyl glycoprotein, unsaturated lipid, isoleucine, and VLDL/LDL are higher (p < 0.05) in the obese with hyperlipidemia. Therefore, they can be used as biomarkers to identify these two types of obesity. | Htun, Khin Thandar; Pan, Jie; Pasanta, Duanghathai; Tungjai, Montree; Udomtanakunchai, Chatchanok; Chancharunee, Sirirat; Kaewjaeng, Siriprapa; Kim, Hong Joo; Kaewkhao, Jakrapong; Kothan, Suchart | Chiang Mai Univ, Fac Associated Med Sci, Ctr Radiat Res & Med Imaging, Dept Radiol Technol, Chiang Mai 50200, Thailand; Shandong Normal Univ, Coll Life Sci, Shandong Prov Key Lab Anim Resistant Biol, Jinan 250014, Peoples R China; Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Nakhon Pathom Rajabhat Univ, Fac Sci & Technol, Ctr Excellence Glass Technol & Mat Sci CEGM, Muang 73000, Nakhon Pathom, Thailand | ; Kim, Hong Joo/AAE-1178-2022 | 57221962831; 55733326300; 57205246803; 8518889700; 55151549700; 24378137700; 55871868200; 59051568100; 23974520300; 6507017165 | ktdhtun28@gmail.com;jiepan@sdnu.edu.cn;duanghathai.pa@gmail.com;mtungjai@gmail.com;chatchanok.u@cmu.ac.th;c.sirirat@gmail.com;siriprapa.k@cmu.ac.th;hongjoo@knu.ac.kr;jakrapong@webmail.npru.ac.th;suchart.kothan@cmu.ac.th; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 11 | 6 | SCIE | BIOLOGY | 2021 | 3.253 | 41.0 | 1.44 | 2025-07-30 | 16 | 18 | H-1 NMR; young adults; obesity; hyperlipidemia; metabolic profile; metabolic syndrome | FATTY LIVER-DISEASE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; DIET; SPECTROSCOPY; OVERWEIGHT; BIOMARKER; INSIGHTS; CHOLINE | 1H NMR; Hyperlipidemia; Metabolic profile; Metabolic syndrome; Obesity; Young adults | English | 2021 | 2021-06 | 10.3390/life11060574 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Waist Circumference and BMI Are Strongly Correlated with MRI-Derived Fat Compartments in Young Adults | Young adulthood is increasingly considered as a vulnerable age group for significant weight gain, and it is apparent that there is an increasing number of new cases of metabolic syndrome developing among this population. This study included 60 young adult volunteers (18-26 years old). All participants obtained a calculated total abdominal fat percentage, subcutaneous fat percentage, and visceral fat percentage using a semiautomatic segmentation technique from T1-weighted magnetic resonance imaging (MRI) images of the abdomen. The results show strongest correlation between abdominal fat and BMI (r = 0.824) followed by subcutaneous fat (r = 0.768), and visceral fat (r = 0.633) respectively, (p < 0.001 for all, after having been adjusted for age and gender). Among anthropometric measurements, waist circumference showed strong correlation with all fat compartments (r = 0.737 for abdominal, r = 0.707 for subcutaneous fat, and r = 0.512 for visceral fat; p < 0.001 for all). The results obtained from examining the blood revealed that there was a moderate positive correlation relationship between all fat compartments with triglyceride, high-density lipoprotein, and fasting glucose levels (p < 0.05 for all). This study suggests that both BMI and waist circumference could be used to assess the fat compartments and treatment targets to reduce the risk of metabolic disorders and health risks in the young adult population. | Pasanta, Duanghathai; Htun, Khin Thandar; Pan, Jie; Tungjai, Montree; Kaewjaeng, Siriprapa; Chancharunee, Sirirat; Tima, Singkome; Kim, Hong Joo; Kaewkhao, Jakrapong; Kothan, Suchart | Chiang Mai Univ, Fac Associated Med Sci, Ctr Radiat Res & Med Imaging, Dept Radiol Technol, Chiang Mai 50200, Thailand; Shandong Normal Univ, Coll Life Sci, Shandong Prov Key Lab Anim Resistant Biol, Jinan 250014, Peoples R China; Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand; Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, Chiang Mai 50200, Thailand; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Nakhon Pathom Rajabhat Univ, Ctr Excellence Glass Technol & Mat Sci CEGM, Muang 73000, Nakhon Pathom, Thailand | ; Tima, Singkome/AAE-5378-2022; Kim, Hong Joo/AAE-1178-2022 | 57205246803; 57221962831; 55733326300; 8518889700; 55871868200; 24378137700; 15073484600; 59051568100; 23974520300; 6507017165 | duanghathai.pas@cmu.ac.th;ktdhtun28@gmail.com;jiepan@sdnu.edu.cn;mtungjai@gmail.com;siriprapa.k@cmu.ac.th;c.sirirat@gmail.com;singkome.tima@cmu.ac.th;hongjoo@knu.ac.kr;jakrapong@webmail.npru.ac.th;suchart.kothan@cmu.ac.th; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 11 | 7 | SCIE | BIOLOGY | 2021 | 3.253 | 41.0 | 2.11 | 2025-07-30 | 22 | 26 | magnetic resonance spectroscopy; abdominal fat; visceral fat; subcutaneous fat; young adult; body-mass index; waist circumference; waist-to-hip ratio | MAGNETIC-RESONANCE-SPECTROSCOPY; SUBCUTANEOUS ADIPOSE-TISSUE; BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; RISK-FACTORS; CHOLESTEROL; OVERWEIGHT; OBESITY; SINGLE | Abdominal fat; Body-mass index; Magnetic resonance spectroscopy; Subcutaneous fat; Visceral fat; Waist circumference; Waist-to-hip ratio; Young adult | English | 2021 | 2021-07 | 10.3390/life11070643 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A phosphor converted RED light for automotive LED rear lamp and compliance with ECE light regulation | In conventional red color lighting LED lamp for vehicles are composed of red color lighting LED and additional transparent or red lenses. Generally red color lighting LED is based on the semiconductor materials as AlGaInP, AlGaAs or GaAsP. Such RED LEDs are mostly affected by temperature. As the temperature increases, the luminous flux droops sharply and lighting efficiency decreases accordingly. In addition, the light color changes due to the wavelength shift phenomenon. This makes the design for automotive ECE regulation for red light very demanding. In this study, it is intended to develop a high-efficiency RED LED light for automobile rear lamps with the phosphor-converted LEDs technology used the characteristics of blue light LED. The luminous flux droop affected by temperature change which is the most important parameter in vehicle lamp performance, is measured, and the compliance with the red light ECE regulation for automobiles is compared and evaluated. For measuring the optical properties, it was performed using the T3Ster TeraLED system. The PC RED LED chips for new development used blue LED based on InGaN (455 nm) and conventional RED LED chips are AllnGaP LEDs (614 nm, 620 nm). To optimize optical properties of PC RED LED, phosphor was applied in 5 grades according to concentration. The best optical properties of PC RED LED shows at the phosphor concentration of 40 %. The results have important implications for improving the performance of automotive red lamps. | Jeong, Seok-Ho; Kim, Jung-Young; Xiao, Xiao; Kim, Young-Suk | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Hyundai Mobis Ltd, Adv Lamp Prod Engn Cell, Gyeonggi Do 16891, South Korea | Kim, Sang-Hoon/AAA-2248-2020 | 57222124223; 57222130756; 57195394085; 36065820800 | caekim@knu.ac.kr; | OPTIK | OPTIK | 0030-4026 | 1618-1336 | 234 | SCIE | OPTICS | 2021 | 2.84 | 41.1 | 0.54 | 2025-07-30 | 9 | 10 | Rear lamp for automobile; Luminous flux droop; Phosphor based red LED; Chromaticity for red light | Chromaticity for red light; Luminous flux droop; Phosphor based red LED; Rear lamp for automobile | Aluminum alloys; Aluminum gallium arsenide; Automobiles; Color; Efficiency; Electric lamps; Gallium alloys; Gallium compounds; III-V semiconductors; Indium alloys; Light emission; Phosphors; Semiconductor alloys; ECE regulations; High-efficiency; Light regulation; Lighting efficiency; Phosphor-converted leds; Temperature changes; Temperature increase; Wavelength shift; Light emitting diodes | English | 2021 | 2021-05 | 10.1016/j.ijleo.2021.166590 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Evaluation of the significance of pseudomyxoma peritonei patients based on the Peritoneal Surface Oncology Group International (PSOGI) classification | Background: Pseudomyxoma peritonei (PMP) is a rare disease characterized by mucinous ascites and deposits on the peritoneal surfaces. The study aimed to assess PMP patients according to the Peritoneal Surface Oncology Group International (PSOGI) classification, as a part of standardization of this rare disease. Methods: This retrospective study analyzed PMP patients who underwent surgery between January 2007 and December 2017. All histologic slides were re-evaluated and the clinical data were collected. According to the PSOGI, PMP was retrospectively classified into three categories: low-grade (LG-PMP), highgrade (HG-PMP), and signet-ring cells (SRC-PMP). The extent of peritoneal involvement was quantified by the peritoneal cancer index (PCI). The completeness of cytoreduction (CCR) was dichotomized as complete or incomplete. Results: Fifty-seven patients were included in this study, consisted of 39 patients with LG-PMP (74.0%), 14 with HG-PMP (20.8%), and 4 with SRC-PMP (5.2%). There was no operative mortality and major complications occurred in 24 patients (31.2%). The 5-year overall survival was 56.2% +/- 8.1% for LG-PMP, 37.5%+/- 12.1% for HG-PMP, and 25.0%+/- 21.7% for SRC-PMP. Concerning CCR, the 5-year overall (complete: 59.5% +/- 8.4% vs. incomplete: 12.7% +/- 8.1%, p = 0.001) and disease-free survival (complete: 38.6% +/- 8.9% vs. incomplete: 7.7% +/- 6.8%, p = 0.001) were significantly different. In a multivariable analysis, PSOGI classification and CCR independently correlated with survival (p = 0.011 and 0.018, respectively). Conclusions: The PSOGI classification provides prognostic stratification, hopefully requiring further validation including every single case of PMP established as a standard criteria. (c) 2021 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). | Lee, Jong Lyul; Kim, Meejeong; Kim, Jihun; Kim, Chan Wook; Ha, Ye Jin; Kim, Seon-Young; Cho, Dong-Hyung; Kim, Jin Cheon | Univ Ulsan, Dept Surg, Asan Med Ctr, Coll Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Univ Ulsan, Dept Pathol, Asan Med Ctr, Coll Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Asan Med Ctr, Inst Innovat Canc Res, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Korea Res Inst Biosci & Biotechnol, Med Genom Res Ctr, Daejeon, South Korea; Kyungpook Natl Univ, Sch Life Sci, Daegu, South Korea | KIM, SEON HAHN/JTU-1415-2023; Lww, Jong/W-1791-2019; Bin Kim, Hong/J-5452-2012; Choi, Hye Rin/JDV-9065-2023 | 55194819000; 57208177678; 57222101434; 55966571500; 38561431400; 55146733100; 35093684400; 55664401800 | jckim@amc.seoul.kr; | ASIAN JOURNAL OF SURGERY | ASIAN J SURG | 1015-9584 | 0219-3108 | 44 | 6 | SCIE | SURGERY | 2021 | 2.808 | 41.1 | 1.16 | 2025-07-30 | 7 | 7 | Pseudomyxoma peritonei; Survival; Validation; Classification; Grade; Outcome | INTRAPERITONEAL CHEMOTHERAPY HIPEC; CYTOREDUCTIVE SURGERY; APPENDICEAL ORIGIN; CLINICOPATHOLOGICAL ANALYSIS; CARCINOMATOSIS; ADENOCARCINOMAS; NEOPLASMS; SURVIVAL; COHORT | Classification; Grade; Outcome; Pseudomyxoma peritonei; Survival; Validation | Cytoreduction Surgical Procedures; Humans; Peritoneal Neoplasms; Prognosis; Pseudomyxoma Peritonei; Retrospective Studies; cytoreductive surgery; human; peritoneum pseudomyxoma; peritoneum tumor; prognosis; retrospective study | English | 2021 | 2021-06 | 10.1016/j.asjsur.2021.01.012 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Health literacy and diabetes self-care activities: The mediating effect of knowledge and patient activation | Background An association between health literacy and health outcomes has been widely reported in the literature. However, models exploring the links between health literacy and the outcomes of health literacy need further testing. The purpose of this study was to examine the pathways of health literacy on diabetes self-care activities amongst patients with Type 2 diabetes. Methods A cross-sectional survey using secondary data analysis was conducted on 155 patients with Type 2 diabetes recruited from the diabetes clinics of two university hospitals in a metropolitan city in South Korea. Structural equation modelling analysis using bootstrapping was carried out using the AMOS software. Results Health literacy had no significant direct effect on diabetes self-care activities. Rather, health literacy had a significant indirect effect on diabetes self-care activities mediated through diabetes knowledge and patient activation. Conclusion These findings indicate that interventions intended to improve self-care activity amongst older adults with low health literacy should include strategies to enhance patients' knowledge, as well as their activation for diabetes self-care. | Kim, Su Hyun | Kyungpook Natl Univ, Coll Nursing, 680 Gukchaebosang Ro, Daegu 41944, South Korea | kim, su/AAK-6271-2021 | 56664542600 | suhyun_kim@knu.ac.kr; | INTERNATIONAL JOURNAL OF NURSING PRACTICE | INT J NURS PRACT | 1322-7114 | 1440-172X | 27 | 4 | SCIE;SSCI | NURSING | 2021 | 2.226 | 41.1 | 1.56 | 2025-07-30 | 11 | 13 | diabetes mellitus; knowledge; nursing; patient participation; self‐ care | EFFICACY; BEHAVIORS; PATHWAYS; ADULTS | diabetes mellitus; knowledge; nursing; patient participation; self-care | Aged; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Health Knowledge, Attitudes, Practice; Health Literacy; Humans; Patient Participation; Self Care; aged; attitude to health; cross-sectional study; health literacy; human; non insulin dependent diabetes mellitus; patient participation; self care | English | 2021 | 2021-08 | 10.1111/ijn.12925 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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