연구성과로 돌아가기
2024 연구성과 (150 / 286)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Speaker-Attributed Training for Multi-Speaker Speech Recognition Using Multi-Stage Encoders and Attention-Weighted Speaker Embedding | Featured Application Speech recognition; speaker adaptation; speaker diarization.Abstract Automatic speech recognition (ASR) aims at understanding naturally spoken human speech to be used as text inputs to machines. In multi-speaker environments, where multiple speakers are talking simultaneously with a large amount of overlap, a significant performance degradation may occur with conventional ASR systems if they are trained by recordings of single talkers. This paper proposes a multi-speaker ASR method that incorporates speaker embedding information as an additional input. The embedding information for each of the speakers in the training set was extracted as numeric vectors, and all of the embedding vectors were stacked to construct a total speaker profile matrix. The speaker profile matrix from the training dataset enables finding embedding vectors that are close to the speakers of the input recordings in the test conditions, and it helps to recognize the individual speakers' voices mixed in the input. Furthermore, the proposed method efficiently reuses the decoder from the existing speaker-independent ASR model, eliminating the need for retraining the entire system. Various speaker embedding methods such as i-vector, d-vector, and x-vector were adopted, and the experimental results show 0.33% and 0.95% absolute (3.9% and 11.5% relative) improvements without and with the speaker profile in the word error rate (WER). | Kim, Minsoo; Jang, Gil-Jin | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 57219221740; 7102646102 | craft8244@naver.com;gjang@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 14 | 18 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 2.5 | 28.3 | 0 | 2025-05-07 | 0 | 1 | speech recognition; speaker embedding; speaker-attributed training | SEPARATION | speaker embedding; speaker-attributed training; speech recognition | Audio recordings; Embeddings; Error statistics; Matrix algebra; Signal encoding; Automatic speech recognition; Embedding information; Embeddings; Human speech; matrix; Multi-stages; Speaker adaptation; Speaker diarization; Speaker embedding; Speaker-attributed training; Speech recognition | English | 2024 | 2024-09 | 10.3390/app14188138 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Stability of Silver-Nanowire-Based Flexible Transparent Electrodes under Mechanical Stress | Flexible organic solar cells (OSCs) are one of the most promising power sources for wearable electronics. A high-quality transparent electrode is one of the indispensable components for OSCs because it guarantees sufficient light transparency and electrical conductivity. Silver nanowires (AgNWs) are considered to be an ideal candidate over commercial rigid indium tin oxide as flexible transparent electrodes (FTEs) because of their superior optoelectronic properties, excellent mechanical flexibility, solution treatability, and high compatibility with semiconductors. However, the stability of AgNWs-based FTEs (AgNWs-FTEs) hinders their further application. In this perspective, we provide state-of-the-art solution-processed AgNWs with enhanced stability and their applications in flexible OSCs. We start with a systematic analysis of the failure mechanisms and evaluation methods of AgNWs-FTEs. Then the key reinforced materials are summarized. Next, the main stability enhancement strategies are briefly discussed. Applications of AgNWs-FTEs in flexible and stretchable OSCs are further surveyed. Finally, an outlook on the current status, future challenges, and emerging strategies in this field is presented. | Ma, Yoohan; Sim, Geon Woo; Jo, Sungjin; Hyun, Dong Choon; Roh, Jae-Seung; Ko, Dongwook; Kim, Jongbok | Kumoh Natl Inst Technol, Dept Mat Sci & Engn, Gumi 39177, South Korea; Kumoh Natl Inst Technol, Dept Energy Engn Convergence, Gumi 39177, South Korea; Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea | 57215733716; 59073915900; 7101724027; 15834575400; 56425149400; 24479440600; 15762365000 | john931023@gmail.com;pr9329@naver.com;sungjin@knu.ac.kr;dong.hyun@knu.ac.kr;jsroh@kumoh.ac.kr;duko1293@gmail.com;jbkim@kumoh.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 14 | 1 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 2.5 | 28.3 | 1.21 | 2025-04-16 | 2 | 3 | silver nanowire; flexible electrode; electrical resistance; compressive stress; tensile stress | ITO FILMS; SOLAR-CELLS; GRAPHENE; PRESSURE; DESIGN | compressive stress; electrical resistance; flexible electrode; silver nanowire; tensile stress | English | 2024 | 2024-01 | 10.3390/app14010420 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Teacher-Student Model Using Grounding DINO and You Only Look Once for Multi-Sensor-Based Object Detection | Object detection is a crucial research topic in the fields of computer vision and artificial intelligence, involving the identification and classification of objects within images. Recent advancements in deep learning technologies, such as YOLO (You Only Look Once), Faster-R-CNN, and SSDs (Single Shot Detectors), have demonstrated high performance in object detection. This study utilizes the YOLOv8 model for real-time object detection in environments requiring fast inference speeds, specifically in CCTV and automotive dashcam scenarios. Experiments were conducted using the 'Multi-Image Identical Situation and Object Identification Data' provided by AI Hub, consisting of multi-image datasets captured in identical situations using CCTV, dashcams, and smartphones. Object detection experiments were performed on three types of multi-image datasets captured in identical situations. Despite the utility of YOLO, there is a need for performance improvement in the AI Hub dataset. Grounding DINO, a zero-shot object detector with a high mAP performance, is employed. While efficient auto-labeling is possible with Grounding DINO, its processing speed is slower than YOLO, making it unsuitable for real-time object detection scenarios. This study conducts object detection experiments using publicly available labels and utilizes Grounding DINO as a teacher model for auto-labeling. The generated labels are then used to train YOLO as a student model, and performance is compared and analyzed. Experimental results demonstrate that using auto-generated labels for object detection does not lead to degradation in performance. The combination of auto-labeling and manual labeling significantly enhances performance. Additionally, an analysis of datasets containing data from various devices, including CCTV, dashcams, and smartphones, reveals the impact of different device types on the recognition accuracy for distinct devices. Through Grounding DINO, this study proves the efficacy of auto-labeling technology in contributing to efficiency and performance enhancement in the field of object detection, presenting practical applicability. | Son, Jinhwan; Jung, Heechul | Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea | ; Jung, Heechul/HTL-7199-2023 | 59073930600; 55652175200 | ii9696ii@knu.ac.kr;heechul@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 14 | 6 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 2.5 | 28.3 | 1.1 | 2025-05-07 | 4 | 5 | deep learning; computer vision; object detection; auto-labeling | auto-labeling; computer vision; deep learning; object detection | English | 2024 | 2024-03 | 10.3390/app14062232 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Time of Flight Distance Sensor-Based Construction Equipment Activity Detection Method | In this study, we delve into a novel approach by employing a sensor-based pattern recognition model to address the automation of construction equipment activity analysis. The model integrates time of flight (ToF) sensors with deep convolutional neural networks (DCNNs) to accurately classify the operational activities of construction equipment, focusing on piston movements. The research utilized a one-twelfth-scale excavator model, processing the displacement ratios of its pistons into a unified dataset for analysis. Methodologically, the study outlines the setup of the sensor modules and their integration with a controller, emphasizing the precision in capturing equipment dynamics. The DCNN model, characterized by its four-layered convolutional blocks, was meticulously tuned within the MATLAB environment, demonstrating the model's learning capabilities through hyperparameter optimization. An analysis of 2070 samples representing six distinct excavator activities yielded an impressive average precision of 95.51% and a recall of 95.31%, with an overall model accuracy of 95.19%. When compared against other vision-based and accelerometer-based methods, the proposed model showcases enhanced performance and reliability under controlled experimental conditions. This substantiates its potential for practical application in real-world construction scenarios, marking a significant advancement in the field of construction equipment monitoring. | Park, Young-Jun; Yi, Chang-Yong | Kyungpook Natl Univ, Intelligent Construct Automat Ctr, Daegu 41566, South Korea | 57191258386; 36614886300 | py0307@knu.ac.kr;cyyi@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 14 | 7 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 2.5 | 28.3 | 0.73 | 2025-05-07 | 1 | 2 | ToF distance sensor; equipment activity recognition; DCNN classification; piston movement; data transformation | ACTIVITY RECOGNITION; SIMULATION; FRAMEWORK; SUPPORT; FEATURES | data transformation; DCNN classification; equipment activity recognition; piston movement; ToF distance sensor | English | 2024 | 2024-04 | 10.3390/app14072859 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Treatment of Swine Wastewater Using the Domestic Microalga Halochlorella rubescens KNUA214 for Bioenergy Production and Carotenoid Extraction | The management of swine wastewater (SW) presents significant environmental challenges, requiring solutions that combine effective treatment with resource recovery. This study highlights the dual role of microalgae in wastewater remediation and bioenergy production. H. rubescens KNUA214 was cultivated in media containing varying concentrations of diluted swine wastewater (DSW; 0%, 25%, 50%, and 100%). Cultivating with Blue Green-11 (BG-11) medium + 50% DSW maximized biomass growth, the chlorophyll content, and carotenoid production. Nutrient removal efficiency in 100% DSW over 8 days demonstrated reductions of 59.3% in total nitrogen, 67.7% in ammonia nitrogen, and 40.7% in total phosphorus, confirming the species' capacity for effective wastewater treatment. The carotenoid analysis using HPLC revealed that astaxanthin, lutein, canthaxanthin, and beta-carotene exhibited the highest levels in BG-11 + 50% DSW. Furthermore, the biomass analyses confirmed its potential for bioenergy applications, with high calorific values and significant polyunsaturated fatty acid concentrations, enhancing its utility for bioenergy and biolubricant production. These findings position H. rubescens KNUA214 as an effective resource for integrating SW management with the sustainable production of high-value biochemicals, offering environmental and economic benefits. | Seo, Yu-Hee; Do, Jeong-Mi; Suh, Ho-Seong; Park, Su-Bin; Yoon, Ho-Sung | Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Blue Carbon Res Ctr, Bioresource Res Ctr, Daegu 41566, South Korea; Nakdonggang Natl Inst Biol Resources NNIBR, Biol Resources Res Dept, Sangju 37242, South Korea | Park, Su-Bin/IVH-9442-2023 | 59489877900; 57208562245; 58139501200; 57201732680; 7402990205 | seoyuhee16@gmail.com;jmdoe09@knu.ac.kr;ibhs@naver.com;sbpark@nnibr.re.kr;hsy@knu.ac.kr; | APPLIED SCIENCES-BASEL | APPL SCI-BASEL | 2076-3417 | 14 | 24 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2024 | 2.5 | 28.3 | 0 | 2025-05-07 | 0 | 0 | microalgae; swine wastewater; bioenergy; biolubricant; carotenoids | PHYSICOCHEMICAL PROPERTIES; FUEL PROPERTIES; BIODIESEL; ACCUMULATION; CULTIVATION; EFFICIENT; REMOVAL; QUALITY; BLENDS; OILS | bioenergy; biolubricant; carotenoids; microalgae; swine wastewater | Carotenoids; Nitrogen removal; Bio-energy; Bioenergy productions; Biolubricants; Dual role; Environmental challenges; Micro-algae; Microalga; Resource recovery; Swine wastewater; Wastewater remediation; Microalgae | English | 2024 | 2024-12 | 10.3390/app142411650 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | High-quality three-dimensional visualization system for light field microscopy using a robust-depth estimation algorithm and holographic optical element-microlens array | We propose a high-quality three-dimensional (3D) visualization system based on light field microscopy using a robust-depth estimation (RDE) algorithm and a holographic optical element-microlens array (HOE-MLA). According to the Bragg angle characteristics, the HOE-MLA allows the simultaneous capture of both images viewed through a dual-channel camera. This system provides high-quality 3D visualization by combining a depth map estimated from the light field with high-resolution two-dimensional (2D) images and texture information. To estimate the depth and shape of micro-objects with high accuracy, a custom-designed RDE algorithm based on reliability analysis and image matting information considers all information obtained from high-resolution 2D and directional-view images. Based on the acquired depth and color/texture information, clear, natural-view 3D visualization of the object is reconstructed, including depth information with high accuracy and high quality, similar to that of a 2D image. The superiority of the proposed system is verified experimentally, and the results indicate that it can be used to easily acquire and display high-quality 3D information of microscopic objects with simple optical structure. | Kwon, Ki-Chul; Kwon, Ki Hoon; Erdenebat, Munkh-Uchral; Wu, Hui-Ying; Choi, Sungho; Kim, Min Young; Kim, Nam | Chungbuk Natl Univ, Sch Informat & Commun Engn, 1 Chungdae Ro, Cheongju 28644, Chungbuk Do, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea | 7201503212; 57190749004; 36166588400; 56515552000; 58803269700; 56739349100; 35494120000 | minykim@knu.ac.kr;namkim@chungbuk.ac.kr; | OPTICS AND LASERS IN ENGINEERING | OPT LASER ENG | 0143-8166 | 1873-0302 | 176 | SCIE | OPTICS | 2024 | 3.7 | 28.4 | 0.75 | 2025-05-07 | 1 | 2 | Anthrax; Epidemiology; Latent infections; Peracute infections; Host resistance; Dosedependent mode | DISPLAY; MODEL | Anthrax; Dosedependent mode; Epidemiology; Host resistance; Latent infections; Peracute infections | Holography; Microlenses; Optical instrument lenses; Textures; Three dimensional computer graphics; Three dimensional displays; Visualization; Anthrax; Depth Estimation; Dose-dependent; Dosedependent mode; Estimation algorithm; High quality; Host resistance; Latent infection; Light fields; Peracute infection; Reliability analysis | English | 2024 | 2024-05 | 10.1016/j.optlaseng.2024.108096 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | AI-assisted classification of AVM endothelial cell phenotypes based on dynamic features | Ham, Seokhoon; Kang, Minwoo; Min, Chanhong; Chung, Ho Yun; Shin, Jennifer H. | Korea Adv Inst Sci & Technol, Daejeon, South Korea; Kyungpook Natl Univ, Daegu, South Korea | BIOPHYSICAL JOURNAL | BIOPHYS J | 0006-3495 | 1542-0086 | 123 | 3 | SCIE | BIOPHYSICS | 2024 | 3.1 | 28.5 | 0 | English | 2024 | 2024-02-08 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Kinetics of Deoxidation of the Molten Blister Copper by Bubbling a Carbon Monoxide and Argon Gas Mixture | A kinetic study was investigated the deoxidation of molten blister copper by bubbling an Ar-CO gas mixture through a submerged nozzle at 1,473 K. The effects of CO gas partial pressure and total gas flow rate were thoroughly investigated. The deoxidation rate increased with the CO partial pressure and total gas flow rate. Furthermore, a mathematical model of the mass transfer rate of reactants and products around the boundary layer of rising bubble was constructed. The deoxidation rate highly depended on the mass transfer of reactants and products through the boundary layer. And the experimental results were well explained by this model. The variation in the rate of CO gas supply per unit time under different reaction conditions was disregarded to analyze oxygen concentration reduction and mass transfer resistances comparatively. As a result, it was determined that the chemical reaction at the reaction interface achieved local chemical equilibrium. Moreover, the mass transfer driving force of CO and CO2 gas significantly influenced the reaction rate under the given conditions. Consequently, it was found that the rate of deoxidation of molten copper through CO gas had a mixed control mechanism involving the mass transfer through both liquid and gas boundary layers. | Lee, So-Yeong; Kim, Hyunsoo; Sohn, Ho-Sang | Kyungpook Natl Univ, Dept Mat Sci & Met Engn, 80 Daehak Ro, Daegu 41566, South Korea | 57208210267; 58967131100; 7201426373 | sohn@knu.ac.kr; | METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE | METALL MATER TRANS B | 1073-5615 | 1543-1916 | 55 | 3 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2024 | 3.1 | 28.6 | 0 | 2025-05-07 | 1 | 0 | LIQUID COPPER; MASS-TRANSFER; OXYGEN | Argon; Boundary layers; Bubble formation; Carbon dioxide; Carbon monoxide; Flow of gases; Gas mixtures; Oxygen supply; Partial pressure; A-carbon; Argon gas mixtures; Blister copper; CO gas mixture; Deoxidation; Effect of CO; Gas flowrate; Kinetic study; Monoxide gas; Submerged nozzles; Mass transfer | English | 2024 | 2024-06 | 10.1007/s11663-024-03044-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Brain-Derived Neurotrophic Factor (BDNF) Enhances Osteogenesis and May Improve Bone Microarchitecture in an Ovariectomized Rat Model | Background: Brain-derived neurotrophic factor (BDNF) has gained attention as a therapeutic agent due to its potential biological activities, including osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of BDNF have not been fully understood. This study aimed to investigate the action of BDNF on the osteoblast differentiation in bone marrow stromal cells, and its influence on signaling pathways. In addition, to evaluate the clinical efficacy, an in vivo animal study was performed. Methods: Preosteoblast cells (MC3T3-E1), bone marrow-derived stromal cells (ST2), and a direct 2D co-culture system were treated with BDNF. The effect of BDNF on cell proliferation was determined using the CCK-8 assay. Osteoblast differentiation was assessed based on alkaline phosphatase (ALP) activity and staining and the protein expression of multiple osteoblast markers. Calcium accumulation was examined by Alizarin red S staining. For the animal study, we used ovariectomized Sprague-Dawley rats and divided them into BDNF and normal saline injection groups. MicroCT, hematoxylin and eosin (H&E), and tartrate-resistant acid phosphatase (TRAP) stain were performed for analysis. Results: BDNF significantly increased ALP activity, calcium deposition, and the expression of osteoblast differentiation-related proteins, such as ALP, osteopontin, etc., in both ST-2 and the MC3T3-E1 and ST-2 co-culture systems. Moreover, the effect of BDNF on osteogenic differentiation was diminished by blocking tropomyosin receptor kinase B, as well as inhibiting c-Jun N-terminal kinase and p38 MAPK signals. Although the animal study results including bone density and histology showed increased osteoblastic and decreased osteoclastic activity, only a portion of parameters reached statistical significance. Conclusions: Our study results showed that BDNF affects osteoblast differentiation through TrkB receptor, and JNK and p38 MAPK signal pathways. Although not statistically significant, the trend of such effects was observed in the animal experiment. | Park, Eugene J.; Truong, Van-Long; Jeong, Woo-Sik; Min, Woo-Kie | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Coll Med, Dept Orthoped Surg, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Jeong, Woo-Sik/AAN-6885-2020 | 55371642100; 55925363400; 10440750200; 8548041000 | osjpark@knu.ac.kr;truong88@knu.ac.kr;wsjeong@knu.ac.kr;wkmin@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 13 | 6 | SCIE | CELL BIOLOGY | 2024 | 5.2 | 28.7 | 1.56 | 2025-05-07 | 5 | 5 | bone formation; brain-derived neurotrophic factor; osteoblastic differentiation | MESENCHYMAL STEM-CELLS; GENE-EXPRESSION; DIFFERENTIATION; INJURY; VEGF | bone formation; brain-derived neurotrophic factor; osteoblastic differentiation | Animals; Brain-Derived Neurotrophic Factor; Calcium; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; 2 (2 amino 3 methoxyphenyl)chromone; adezmapimod; alkaline phosphatase; anthra[1,9 cd]pyrazol 6(2h) one; ascorbic acid; bone morphogenetic protein 2; brain derived neurotrophic factor receptor; mitogen activated protein kinase; mitogen activated protein kinase p38; osteoclast differentiation factor; osteopontin; transcription factor osterix; transcription factor RUNX2; brain derived neurotrophic factor; calcium; mitogen activated protein kinase p38; animal cell; animal experiment; animal model; animal tissue; Article; bone density; bone development; bone marrow stroma cell; bone microarchitecture; bone tissue; cell culture; cell proliferation; coculture; colorimetry; computer assisted tomography; controlled study; extracellular matrix; female; histology; JNK signaling; MAPK signaling; micro-computed tomography; nonhuman; osteoblast; osteoclast; osteoclastogenesis; osteoporosis; ovariectomy; protein expression; rat; rat model; signal transduction; Sprague Dawley rat; stroma cell; Western blotting; animal; metabolism | English | 2024 | 2024-03 | 10.3390/cells13060518 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Evolving Paradigms in Sepsis Management: A Narrative Review | Sepsis, a condition characterized by life-threatening organ dysfunction due to a dysregulated host response to infection, significantly impacts global health, with mortality rates varying widely across regions. Traditional therapeutic strategies that target hyperinflammation and immunosuppression have largely failed to improve outcomes, underscoring the need for innovative approaches. This review examines the development of therapeutic agents for sepsis, with a focus on clinical trials addressing hyperinflammation and immunosuppression. It highlights the frequent failures of these trials, explores the underlying reasons, and outlines current research efforts aimed at bridging the gap between theoretical advancements and clinical applications. Although personalized medicine and phenotypic categorization present promising directions, this review emphasizes the importance of understanding the complex pathogenesis of sepsis and developing targeted, effective therapies to enhance patient outcomes. By addressing the multifaceted nature of sepsis, future research can pave the way for more precise and individualized treatment strategies, ultimately improving the management and prognosis of sepsis patients. | Kim, Min-Ji; Choi, Eun-Joo; Choi, Eun-Jung | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea; Daegu Catholic Univ, Sch Med, Dept Anesthesiol & Pain Med, Daegu 42472, South Korea; Daegu Catholic Univ, Sch Med, Dept Anat, Duryugongwon Ro 17gil, Daegu 42472, South Korea | ; Kim, Minji/AAQ-2339-2020 | 57206189095; 58039921000; 57218919440 | kmj_endo@knuh.kr;sthgood9@naver.com;ejchoi@cu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 13 | 14 | SCIE | CELL BIOLOGY | 2024 | 5.2 | 28.7 | 1.15 | 2025-05-07 | 8 | 8 | sepsis; hyperinflammation; immune paralysis | TUMOR-NECROSIS-FACTOR; INTERLEUKIN-6 RECEPTOR ANTAGONISTS; INFLAMMATORY RESPONSE SYNDROME; PLACEBO-CONTROLLED TRIAL; CRITICALLY-ILL PATIENTS; TOLL-LIKE RECEPTORS; SEPTIC SHOCK; DOUBLE-BLIND; MOLECULAR-MECHANISMS; FRAGMENT AFELIMOMAB | hyperinflammation; immune paralysis; sepsis | Humans; Inflammation; Sepsis; alkaline phosphatase; cytotoxic T lymphocyte antigen 4; fludrocortisone; heat shock protein; hepatitis A virus cellular receptor 2; high mobility group B1 protein; hydrocortisone; immunoglobulin; immunoglobulin enhancer binding protein; interferon induced helicase C domain containing protein 1; interleukin 1; interleukin 10; interleukin 1beta; interleukin 37; interleukin 4; interleukin 6; interleukin 8; lipopolysaccharide; mammalian target of rapamycin complex 1; myeloid differentiation factor 88; nucleotide binding oligomerization domain like receptor; pathogen associated molecular pattern; polymyxin B; programmed death 1 receptor; protein tyrosine phosphatase SHP 2; recombinant granulocyte macrophage colony stimulating factor; toll like receptor 2; toll like receptor 3; toll like receptor 4; toll like receptor 5; toll like receptor 7; toll like receptor 9; transcription factor AP 1; transforming growth factor beta; tumor necrosis factor; acute kidney failure; apoptosis; autoimmune disease; clinical trial (topic); cytokine production; cytokine release; extracellular trap; hospital mortality; human; hyperinflammation; hypotension; immune deficiency; immune dysregulation; immune paralysis; immune response; immune system; immunomodulation; inflammation; melanoma; mitochondrial dynamics; mortality rate; myeloid-derived suppressor cell; neutrophil extracellular trap; oxidative stress; paralysis; personalized medicine; phase 1 clinical trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); phenotype; randomized controlled trial (topic); Review; sepsis; septic shock; Stroop test; systematic review; systemic inflammatory response syndrome; treatment outcome; upregulation; therapy | English | 2024 | 2024-07 | 10.3390/cells13141172 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Hopping the Hurdle: Strategies to Enhance the Molecular Delivery to the Brain through the Blood-Brain Barrier | Modern medicine has allowed for many advances in neurological and neurodegenerative disease (ND). However, the number of patients suffering from brain diseases is ever increasing and the treatment of brain diseases remains an issue, as drug efficacy is dramatically reduced due to the existence of the unique vascular structure, namely the blood-brain barrier (BBB). Several approaches to enhance drug delivery to the brain have been investigated but many have proven to be unsuccessful due to limited transport or damage induced in the BBB. Alternative approaches to enhance molecular delivery to the brain have been revealed in recent studies through the existence of molecular delivery pathways that regulate the passage of peripheral molecules. In this review, we present recent advancements of the basic research for these delivery pathways as well as examples of promising ventures to overcome the molecular hurdles that will enhance therapeutic interventions in the brain and potentially save the lives of millions of patients. | Cogill, Sinnead Anne; Lee, Jae-Hyeok; Jeon, Min-Tae; Kim, Do-Geun; Chang, Yongmin | Korea Brain Res Inst, Dementia Res Grp, Daegu 41062, South Korea; Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept Brain & Cognit Sci, Daegu 42988, South Korea; Korea Adv Inst Sci & Technol KAIST, Dept Bio & Brain Engn, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu 41944, South Korea | 59142974300; 59143033500; 56018969800; 55797863700; 7501840633 | sinneadcogill@dgist.ac.kr;eprince1015@kaist.ac.kr;jmt1986@kbri.re.kr;kimvet0911@kbri.re.kr;ychang@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 13 | 10 | SCIE | CELL BIOLOGY | 2024 | 5.2 | 28.7 | 1.61 | 2025-05-07 | 7 | 8 | neurodegenerative disease; blood-brain barrier; drug delivery | P-GLYCOPROTEIN EXPRESSION; RECEPTOR-MEDIATED TRANSCYTOSIS; CENTRAL-NERVOUS-SYSTEM; TIGHT JUNCTION; ALZHEIMERS-DISEASE; IN-VITRO; DRUG-DELIVERY; COATED NANOPARTICLES; TRANSPORT ACTIVITY; ENDOTHELIAL-CELLS | blood–brain barrier; drug delivery; neurodegenerative disease | Animals; Biological Transport; Blood-Brain Barrier; Brain; Drug Delivery Systems; Humans; aducanumab; amiodarone; breast cancer resistance protein; cyclosporin A derivative; dasatinib; dexverapamil; doxorubicin; drug carrier; fibrinogen; immunoglobulin; laniquidar; lecanemab; magnetic nanoparticle; matrix metalloproteinase; metal nanoparticle; methotrexate; multidrug resistance protein 1; quantum dot; quinidine; quinine; reactive oxygen metabolite; solid lipid nanoparticle; solute carrier protein; tariquidar; vasculotropin; verapamil; zosuquidar; antigen recognition; apoptosis; astrocyte; autoimmune encephalomyelitis; bioavailability; blood brain barrier; cancer chemotherapy; cytokine release; cytotoxicity; drug delivery system; drug efficacy; drug release; endocytosis; exocytosis; glucose metabolism; human; ligand binding; molecular dynamics; multimodal imaging; nerve degeneration; nonhuman; nuclear magnetic resonance imaging; Parkinson disease; particle size; pericyte; photodynamic therapy; Review; thermostability; tight junction; transcytosis; ubiquitination; upregulation; zeta potential; animal; brain; metabolism; procedures; transport at the cellular level | English | 2024 | 2024-05 | 10.3390/cells13100789 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | LINC01270 Regulates the NF-κB-Mediated Pro-Inflammatory Response via the miR-326/LDOC1 Axis in THP-1 Cells | Long intergenic noncoding (LINC)01270 is a 2278 bp transcript belonging to the intergenic subset of long noncoding (lnc)RNAs. Despite increased reports of LINC01270's involvement in different diseases, evident research on its effects on inflammation is yet to be achieved. In the present study, we investigated the potential role of LINC01270 in modulating the inflammatory response in the human monocytic leukemia cell line THP-1. Lipopolysaccharide treatment upregulated LINC01270 expression, and siRNA-mediated suppression of LINC01270 enhanced NF-kappa B activity and the subsequent production of cytokines IL-6, IL-8, and MCP-1. Interestingly, the knockdown of LINC01270 downregulated expression of leucine zipper downregulated in cancer 1 (LDOC1), a novel NF-kappa B suppressor. An analysis of the LINC01270/micro-RNA (miRNA)/protein interactome profile identified miR-326 as a possible mediator. Synthetic RNA agents that perturb the interaction among LINC01270, miR-326, and LDOC1 mRNA mitigated the changes caused by LINC01270 knockdown in THP-1 cells. Additionally, a luciferase reporter assay in HEK293 cells further confirmed that LINC01270 knockdown enhances NF-kappa B activation, while its overexpression has the opposite effect. This study provides insight into LINC01270's role in modulating inflammatory responses to lipopolysaccharide stimulation in THP-1 cells via the miR-326/LDOC1 axis, which negatively regulates NF-kappa B activation. | Arab, Imene; Lim, Su-Geun; Suk, Kyoungho; Lee, Won-Ha | Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea | 58663912800; 56044587400; 7005114595; 57205609794 | arabimene07@gmail.com;sugeun624@hanmail.net;whl@knu.ac.kr; | CELLS | CELLS-BASEL | 2073-4409 | 13 | 23 | SCIE | CELL BIOLOGY | 2024 | 5.2 | 28.7 | 0 | 2025-05-07 | 0 | 0 | LINC01270; NF-kappa B signaling; miR-326; LDOC1; inflammation | CANCER; LDOC1; EXPRESSION; PROTEIN | inflammation; LDOC1; LINC01270; miR-326; NF-κB signaling | Humans; Inflammation; Lipopolysaccharides; MicroRNAs; NF-kappa B; RNA, Long Noncoding; Signal Transduction; THP-1 Cells; beta actin; immunoglobulin enhancer binding protein; interleukin 6; interleukin 8; leucine zipper downregulated in cancer 1; lipopolysaccharide; long untranslated RNA; long untranslated RNA 01270; microRNA; microRNA 326; monocyte chemotactic protein 1; small interfering RNA; synaptotagmin I; toll like receptor 4; unclassified drug; immunoglobulin enhancer binding protein; lipopolysaccharide; long untranslated RNA; microRNA; MIRN326 microRNA, human; Article; bioinformatics; cell phagocytosis; controlled study; densitometry; enzyme linked immunosorbent assay; flow cytometry; gene knockdown; gene overexpression; gene sequence; genetic transfection; human; human cell; inflammation; luciferase assay; NF kB signaling; polyacrylamide gel electrophoresis; protein expression; protein phosphorylation; protein protein interaction; protein secretion; real time polymerase chain reaction; receptor down regulation; RNA isolation; THP-1 cell line; Western blotting; genetics; inflammation; metabolism; pathology; signal transduction | English | 2024 | 2024-12 | 10.3390/cells13232027 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Formation of Human Arteriovenous Malformation Organoids and Their Characteristics | Arteriovenous malformations (AVMs) are characterized by direct connections between arteries and veins without intervening capillaries, with the concomitant formation of abnormal vascular networks associated with angiogenesis. However, the current understanding of the diagnosis and treatment of AVMs is limited, and no in vitro disease models exist at present for studying this condition. In this study, we produced endothelial cells (ECs) in two-dimensional cultures and three-dimensional (3D) blood vessel organoids (BVOs), comparing gene expression profiles between normal and AVM organoids. The normal and AVM organoids were examined via immunofluorescence staining using CD31 and phalloidin. The AVM organoids showed significantly higher expression levels of CD31 and phalloidin than the normal organoids. Genes such as FSTL1, associated with angiogenesis, showed significantly higher expression in the AVM organoids than in the normal organoids. In contrast, the MARCKS gene exhibited no significant difference in expression between the two types of organoids. The capillaries and related CSPG4 genes exhibited the lowest expression in the 3D AVM organoids. Furthermore, hsa-mir-135b-5p, a small RNA related to AVMs, showed elevated expression in AVM tissues and significantly higher levels in 3D AVM organoids. In our study, we were able to successfully establish AVM organoids (hBVOs) containing ECs and mural cells through advancements in stem cell and tissue engineering. These organoids serve as valuable models for investigating disease mechanisms, drug development, and screening potential therapeutic interventions in drug discovery. These findings contribute essential insights for the development of treatment strategies targeting AVMs. | Oh, Eun Jung; Kim, Hyun Mi; Kwak, Suin; Huh, Chanhoe; Chung, Ho Yun | Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu 41944, South Korea; Yonsei Univ, Coll Med, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu 41944, South Korea | 35746789300; 57261065200; 57735418300; 59469633200; 7404007181 | fullrest74@knu.ac.kr;sarang7939@knu.ac.kr;suin8349@naver.com;99skychan@gmail.com;chunghoyun@gmail.com; | CELLS | CELLS-BASEL | 2073-4409 | 13 | 23 | SCIE | CELL BIOLOGY | 2024 | 5.2 | 28.7 | 0 | 2025-05-07 | 0 | 0 | arteriovenous malformations; blood vessel organoid; three-dimensional culture; induced pluripotent stem cells | GENERATION; DISEASE | arteriovenous malformations; blood vessel organoid; induced pluripotent stem cells; three-dimensional culture | Arteriovenous Malformations; Endothelial Cells; Humans; MicroRNAs; Organoids; CD34 antigen; methylnitrosourea; microRNA; accessory cell; adipose derived stem cell; angiogenesis; angioosteohypertrophy syndrome; arteriovenous malformation; Article; controlled study; digital subtraction angiography; endothelium cell; female; fibroblast; flow cytometry; gene expression; human; human cell; hypoxia; immunocytochemistry; immunofluorescence; male; mesenchymal stem cell; middle aged; nuclear reprogramming; organoid; pluripotent stem cell; protein expression; real time polymerase chain reaction; Rendu Osler Weber disease; reverse transcription polymerase chain reaction; tissue engineering; upregulation; vascular smooth muscle cell; arteriovenous malformation; endothelium cell; genetics; metabolism; pathology | English | 2024 | 2024-12 | 10.3390/cells13231955 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Arduino practice judgment system based on function execution log in virtual execution environment | Recently, automatic judgment systems have been widely used in various computer science lectures, and these systems are mainly developed for languages with a console-based practice environment. On the other hand, embedded systems such as Arduino are executed in a hardware-based environment and their verification is conducted by manually checking the operation of the hardware. Therefore, it is not easy to automatically judge the Arduino system developed by students. In the embedded system, hardware and software have to be developed at the same time, and it increases effort and time for the instructors to teach students, especially in practice-based learning. The study in this article proposes an Arduino practice judgment system based on the function execution log in virtual execution environment. It performs both Fritzing-based hardware configuration checking and source code testing based on virtual execution environment, where hardware operations are replaced by mock-up functions. In addition, more diverse practices are possible by providing an experimental environment where students can freely enter input data and check the results. A case study shows that the developed system can be applied to the lectures and help reduce instructors' work and increase students' understanding through the system. | Seo, Kangbok; Kim, Junhyung; Lee, Woojin | Kyungpook Natl Univ, Sch Comp Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea; Yeungnam Univ, Coll Sci & Technol, Daegu, South Korea | 57195260523; 55720070800; 55682653854 | woojin@knu.ac.kr; | COMPUTER APPLICATIONS IN ENGINEERING EDUCATION | COMPUT APPL ENG EDUC | 1061-3773 | 1099-0542 | 32 | 2 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;EDUCATION, SCIENTIFIC DISCIPLINES;ENGINEERING, MULTIDISCIPLINARY | 2024 | 2.2 | 28.8 | 0.5 | 2025-05-07 | 0 | 1 | Arduino practice; automated assessment; automated feedback; automated judgment system; computer science education | Arduino practice; automated assessment; automated feedback; automated judgment system; computer science education | Automation; Computer hardware; E-learning; Education computing; Embedded systems; Engineering education; Arduino practice; Automated assessment; Automated feedback; Automated judgment system; Computer Science Education; Embedded hardware; Embedded-system; Execution logs; System hardware; Virtual execution environments; Students | English | 2024 | 2024-03 | 10.1002/cae.22695 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Refugees as perceived threat: College students' attitudes towards refugees in South Korea | In 2018, the influx of Yemeni asylum seekers generated the unprecedented politicization of the refugee issue in South Korea. This paper explored South Korean attitudes towards refugees by collecting data from Korean college students. In doing so, we looked into what led to negative attitudes towards refugees and the role perceived threats play as a mediator. Following previous studies on intergroup threat theory, we noted that threat perception was a useful tool in understanding intergroup prejudice and anxiety as perceived threats and their antecedents were found to explain a significant amount of the attitudes towards refugees. We also found strong interconnections between prejudices towards different minority groups, including Islamophobia, homophobia and anti-refugee attitudes. This finding supported the idea that such prejudices are part of a larger intolerant belief system towards minority groups in general. | Yuk, Joowon; Shin, Hyoung-jin | Kyungpook Natl Univ, Dept Sociol, Daegu, South Korea | 57194626233; 26436168300 | h.shin@knu.edu; | INTERNATIONAL MIGRATION | INT MIGR | 0020-7985 | 1468-2435 | 62 | 2 | SSCI | DEMOGRAPHY | 2024 | 2.1 | 29.0 | 0 | 2025-05-07 | 1 | 1 | South Korea; asylum seeker; minority group; refugee; student | English | 2024 | 2024-04 | 10.1111/imig.13238 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: