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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Editorial Material | A Case of Hepatic Immunoglobulin G4-Related Disease Presenting as an Inflammatory Pseudotumor and Sclerosing Cholangitis | An inflammatory pseudotumor is a benign disease characterized by tumor-like lesions consisting of inflammatory cells including plasma cells and fibrous tissue. Recently, some inflammatory pseudotumor cases proved to be a form of Immunoglobulin G4-related disease (IgG4-RD). This novel clinical entity, recognized as a fibroinflammatory condition, is characterized by lymphoplasmacytic infiltration with a predominance of IgG4-positive plasma cells, storiform fibrosis, and often elevated serum IgG4 concentrations. We report a case of IgG4-RD in the form of an inflammatory pseudotumor in the liver with combined sclerosing cholangitis. We recommend that for diagnosing IgG4-RD accurately, it is important to obtain adequate tissue samples and follow-up the lesion in clinical practice. | Jang, Se Young; Han, Young Seok; Lee, Sang Yub; Han, Ja Ryung; Kweon, Young Oh; Tak, Won Young; Park, Soo Young; Lee, Yu Rim; Ryeom, Hun Kyu; Cha, Jung Guen; Hong, Jihoon; Kang, Yoo Na | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Radiol, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Forens Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea | ; Lee, Joo/C-3851-2013 | 57202881977; 7404096216; 56016177400; 57214671308; 7004694832; 7004074582; 57191674344; 57194094753; 6505864513; 57206855971; 57215858314; 7402784356 | vocjsy@knu.ac.kr;gshys@knu.ac.kr;sangyub@knu.ac.kr;jh40356@gmail.com;yokweon@knu.ac.kr;wytak@knu.ac.kr;psyoung@knu.ac.kr;deblue00@naver.com;hkryeom@knu.ac.kr;ircha7527@knu.ac.kr;blushain@knu.ac.kr;yoonakang@knu.ac.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 6 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 0.4 | 2025-06-25 | 2 | 3 | immunoglobulin G4-related disease; cholangitis; sclerosing; immunohistochemistry; biopsy; liver; surgery | biopsy; cholangitis; immunoglobulin G4-related disease; immunohistochemistry; liver; sclerosing; surgery | alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; bilirubin; C reactive protein; gamma glutamyltransferase; immunoglobulin G; immunoglobulin G4; prednisolone; adult; Article; backache; bile duct dilatation; biliary tract drainage; case report; cholangiography; cholangitis; cholestasis; clinical article; computer assisted tomography; diagnostic accuracy; drug hypersensitivity; drug withdrawal; erythrocyte sedimentation rate; fever; follow up; hepatectomy; hepatic inflammatory pseudotumor; human; human tissue; immunoglobulin G4 related disease; immunohistochemistry; laboratory test; laparoscopic cholecystectomy; leukocyte count; liver abscess; liver biopsy; liver nodule; male; middle aged; moon face; recanalization; recurrent infection; repeat procedure; sclerosing cholangitis; tumor diagnosis; ultrasound guided biopsy; upper abdominal pain | English | 2022 | 2022-06 | 10.3390/diagnostics12061497 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comparative investigation on antibacterial studies of Oxalis corniculata and silver nanoparticle stabilized graphene surface | In this study, we report a facile method for the partial exfoliation of graphite into graphene and simultaneous surface stabilization of graphene and silver nanoparticles using a plant extract from Oxalis corniculata (Puliyarai Keerai). Four graphene composites were prepared through sonication: graphene-plant extract prepared at room temperature of about 27 degrees C (G-PRT) and 70 degrees C (G-PHT), and graphene-plant extract with silver nanoparticles prepared using NH4OH (G-PAgNH4) and NaOH (G-PAgNa). The composites were characterized using X-ray diffraction, Raman spectroscopy, field-emission scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and thermogravimetric analyses. The characterizations revealed the small sizes of the graphene sheets in the composites than in graphite, silver nanoparticles (AgNPs) with diameters of similar to 10 nm, and uniform distributions of the plant extract and AgNPs on the graphene surface. The graphene composites exhibited significant antibacterial potential against both Gram-negative (Salmonella typhimurium and Escherichia coli) and Gram-positive (Bacillus cereus and Staphylococcus aureus) microorganisms. G-PAgNa composites exhibited the lowest (10 mu g/mL) minimum inhibitory concentration and minimum bacterial concentration values against S. aureus and S. typhimurium. [GRAPHICS] . | Perumal, Suguna; Atchudan, Raji; Ramalingam, Srinivasan; Edison, Thomas Nesakumar Jebakumar Immanuel; Lee, Hyang Moo; Cheong, In Woo; Devarajan, Natarajan; Lee, Yong Rok | Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, Gyeongsangbuk D, South Korea; Sejong Univ, Dept Chem, Seoul 143747, South Korea; Yeungnam Univ, Dept Food Sci & Technol, Gyongsan 38541, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Dept Appl Chem, Daegu 41566, South Korea; Periyar Univ, Sch Biosci, Dept Biotechnol, Nat Drug Res Lab, Salem 636011, Tamil Nadu, India | Edison, Thomas/N-8909-2015; D., Natarajan/ABB-1036-2020; Lee, Yong/K-6373-2015; Ramalingam, Srinivasan/AAN-4585-2020; RAJI, ATCHUDAN/C-9904-2017; perumal, suguna/N-9075-2017 | 56673798900; 26648054700; 57202134239; 6506181821; 55598631800; 7006733373; 7003295307; 57330662900 | suguna.perumal@gmail.com;yrlee@yu.ac.kr; | JOURNAL OF MATERIALS SCIENCE | J MATER SCI | 0022-2461 | 1573-4803 | 57 | 25 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 4.5 | 37.6 | 0.65 | 2025-06-25 | 8 | 8 | ESCHERICHIA-COLI; GRAPHITE OXIDE; CHEMICAL-REDUCTION; BLOCK-COPOLYMERS; ESSENTIAL OILS; DISPERSIONS; MEMBRANE; EXFOLIATION; EXTRACTION; NANOSHEETS | Bacteriology; Escherichia coli; Field emission microscopes; Graphene; Graphite; High resolution transmission electron microscopy; Plant extracts; Salmonella; Scanning electron microscopy; Silver nanoparticles; Sodium hydroxide; Thermogravimetric analysis; X ray photoelectron spectroscopy; Anti-bacterial studies; Antibacterials; Facile method; Field emission scanning electron microscopy; Graphene composites; Graphene sheets; Partial exfoliation; Surface stabilization; Uniform distribution; X- ray diffractions; Metal nanoparticles | English | 2022 | 2022-07 | 10.1007/s10853-022-07289-3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Deep Learning-Based Four-Region Lung Segmentation in Chest Radiography for COVID-19 Diagnosis | Imaging plays an important role in assessing the severity of COVID-19 pneumonia. Recent COVID-19 research indicates that the disease progress propagates from the bottom of the lungs to the top. However, chest radiography (CXR) cannot directly provide a quantitative metric of radiographic opacities, and existing AI-assisted CXR analysis methods do not quantify the regional severity. In this paper, to assist the regional analysis, we developed a fully automated framework using deep learning-based four-region segmentation and detection models to assist the quantification of COVID-19 pneumonia. Specifically, a segmentation model is first applied to separate left and right lungs, and then a detection network of the carina and left hilum is used to separate upper and lower lungs. To improve the segmentation performance, an ensemble strategy with five models is exploited. We evaluated the clinical relevance of the proposed method compared with the radiographic assessment of the quality of lung edema (RALE) annotated by physicians. Mean intensities of segmented four regions indicate a positive correlation to the regional extent and density scores of pulmonary opacities based on the RALE. Therefore, the proposed method can accurately assist the quantification of regional pulmonary opacities of COVID-19 pneumonia patients. | Kim, Young-Gon; Kim, Kyungsang; Wu, Dufan; Ren, Hui; Tak, Won Young; Park, Soo Young; Lee, Yu Rim; Kang, Min Kyu; Park, Jung Gil; Kim, Byung Seok; Chung, Woo Jin; Kalra, Mannudeep K.; Li, Quanzheng | Seoul Natl Univ Hosp, Transdisciplinary Dept Med & Adv Technol, Seoul 03080, South Korea; Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Daegu 42415, South Korea; Catholic Univ, Daegu Sch Med, Dept Internal Med, Daegu 42472, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Daegu 42601, South Korea | Park, Jung/AAK-5167-2020; Kim, Seul Kee/A-6076-2015; Kalra, Mannudeep/LXW-4237-2024; Kang, Min Kyu/U-8050-2018; Wu, Dufan/AFZ-1956-2022; Kang, Min/U-8050-2018 | 57208003578; 44861409500; 55286668100; 57214672137; 7004074582; 57191674344; 57194094753; 59142854300; 57216816399; 55974276800; 55741230500; 7007035549; 7405862484 | younggon2.kim@gmail.com;KKIM24@partners.org;dwu6@mgh.harvard.edu;HREN2@mgh.harvard.edu;MKALRA@mgh.harvard.edu;psyoung0419@gmail.com;deblue00@naver.com;gsnrs@naver.com;kbs9225@cu.ac.kr;chung50@dsmc.or.kr;li.quanzheng@mgh.harvard.edu; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 2.26 | 2025-06-25 | 13 | 17 | COVID-19; deep learning; segmentation; detection; lung; left hilum; carina; RALE | Carina; COVID-19; Deep learning; Detection; Left hilum; Lung; RALE; Segmentation | adult; aged; Article; coronavirus disease 2019; deep learning; female; human; image segmentation; left lung; lung; lung angiography; lung edema; major clinical study; male; middle aged; motor dysfunction assessment; physician; pneumonia; retrospective study; right lung; thorax radiography; training; validation process | English | 2022 | 2022-01 | 10.3390/diagnostics12010101 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Diagnostic Accuracy of Loop-Mediated Isothermal Amplification Assay for Group B Streptococcus Detection in Recto-Vaginal Swab: Comparison with Polymerase Chain Reaction Test and Conventional Culture | A rapid method for obtaining group B streptococcus (GBS) screening results has been required in the obstetric field. We aimed to determine the diagnostic performance of the Loop-Mediated Isothermal Amplification (LAMP) assay is acceptable compared to the existing polymerase chain reaction (PCR) assay. The study involved 527 pregnant women aged 19 to 44 years. Rectovaginal swabs were collected between 35 and 37 weeks of gestation or prior to impending preterm births or term labor without GBS screening. We presented the diagnostic performance of the LAMP assay with a 95% confidence interval (CI) compared to the PCR and microbiological culture. In total, 115 (21.8%), 115 (21.8%) and 23 (4.4%) patients showed positive results using the LAMP, PCR assay and microbiological culture method, respectively. The LAMP assay showed 100% sensitivity (95% CI, 96.8-100.0), 100% specificity (95% CI, 99.1-100.0) and 100% diagnostic accuracy (95% CI, 99.3-100.0) with the reference being the PCR assay. Meanwhile, the LAMP assay showed 87.0% sensitivity (95% CI, 71.0-100.0), 81.2% specificity (95% CI, 77.6-84.7), and 81.4% diagnostic accuracy (95% CI, 78.0-84.8) with the microbiological culture as a reference. This study presented the LAMP assay as an acceptable method for GBS screening with a similar performance to the existing PCR method. | Sung, Ji-Hee; Cha, Hyun-Hwa; Lee, Nan-Young; Lee, Won-Ki; Choi, Yeseul; Han, Hyung-Soo; Lee, Yoo-Young; Chong, Gun-Oh; Seong, Won-Joon | Sungkyunkwan Univ, Samsung Med Ctr, Dept Obstet & Gynecol, Sch Med, Seoul 06351, South Korea; Kyungpook Natl Univ, Dept Obstet & Gynecol, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Lab Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Med Informat, Daegu 41944, South Korea; Kyungpook Natl Univ, Clin Omics Res Ctr, Sch Med, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41405, South Korea | ; lee, nan/HZM-0321-2023 | 56347330000; 37033517800; 57209204358; 57207141046; 57226123444; 7401969388; 29767612900; 23099068000; 26656946000 | jihee.sung@samsung.com;chh9861@knu.ac.kr;leenanyoung70@gmail.com;wonlee@knu.ac.kr;yeseul.choi830@gmail.com;hshan@knu.ac.kr;yooyoung.lee@samsung.com;gochong@knu.ac.kr;wiseong@knu.ac.kr;wjseong@knu.ac.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 7 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 0.53 | 2025-06-25 | 3 | 4 | group B streptococcus; diagnosis; loop-mediated isothermal amplification assay; polymerase chain reaction assay | COLONIZATION | diagnosis; group B streptococcus; loop-mediated isothermal amplification assay; polymerase chain reaction assay | RNA 16S; adult; Article; bacterium detection; controlled study; diagnostic accuracy; diagnostic test accuracy study; DNA extraction; female; gestational age; human; labor; loop mediated isothermal amplification; major clinical study; maternal age; matrix assisted laser desorption ionization time of flight mass spectrometry; oligonucleotide probe; polymerase chain reaction; premature labor; rectal swab; sensitivity and specificity; statistically significant result; Streptococcus agalactiae; vagina smear | English | 2022 | 2022-07 | 10.3390/diagnostics12071569 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Evaluation of Depth of Invasion and Tumor Thickness as a Prognostic Factor for Early-Stage Oral Squamous Cell Carcinoma: A Retrospective Study | The aim of this study was to compare the effect of using depth of invasion (DOI) versus tumor thickness (TT) as a prognostic factor for early-stage oral squamous cell carcinoma (OSCC). A total of 57 patients with early-stage OSCC treated surgically from 2009 to 2014 at our institution were reviewed retrospectively. Histopathological measurement of DOI and TT was performed. The validation of DOI and TT as prognostic factors was conducted using a Kaplan-Meier survival analysis. TT had no association with disease-specific survival (DSS) or progression-free survival (PFS) in this cohort; however, increased DOI was significantly associated with decreased DSS but not correlated to decreased PFS. The T category of the 7th edition of AJCC was statistically associated with both DSS and PFS; however, the T category of the 8th edition of the AJCC was only associated with DSS. In this study group, TT could not be used as a prognostic factor, and DOI was not by itself sufficient to predict prognosis for early-stage OSCC. The T category in AJCC 8th Edition cannot be considered the sole prognostic factor for early OSCC, so additional prognostic factors may need to be considered. | Lee, You-Jung; Kwon, Tae-Geon; Kim, Jin-Wook; Lee, Sung-Tak; Hong, Su-Hyung; Choi, So-Young | Kyungpook Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, 2175 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Microbiol & Immunol, 2175 Dalgubeol Daero, Daegu 41940, South Korea | ; Lee, Jong-Chan/AAJ-2401-2020 | 57385615500; 35205433300; 55862646000; 55931708300; 8691449100; 57202918688 | leeyj7544@gmail.com;kwondk@knu.ac.kr;vocaleo@knu.ac.kr;st0907@knu.ac.kr;hongsu@knu.ac.kr;dentalchoi@knu.ac.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 1.2 | 2025-06-25 | 9 | 9 | early-stage oral squamous cell carcinoma (OSCC); depth of invasion (DOI); tumor thickness (TT); T category; disease-specific survival (DSS); progression-free survival (PFS) | AMERICAN JOINT COMMITTEE; 4TH EDITION; NECK; CANCER; HEAD; DISEASE | Depth of invasion (DOI); Disease-specific survival (DSS); Early-stage oral squamous cell carcinoma (OSCC); Progression-free survival (PFS); T category; Tumor thickness (TT) | adult; aged; Article; buccal mucosa; cancer growth; cancer prognosis; cancer recurrence; cancer size; controlled study; depth of invasion; disease specific survival; early cancer; elective surgery; female; gingiva; histopathology; human; human tissue; major clinical study; male; mouth squamous cell carcinoma; neck dissection; postoperative care; primary tumor; progression free survival; retrospective study; tumor invasion; tumor thickness | English | 2022 | 2022-01 | 10.3390/diagnostics12010020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Experimental and theoretical investigation of the effect of Sn on κ-Ga2O3 growth | In this work, the effect of Sn doping on the formation of an orthorhombic kappa-Ga2O3 was investigated through experiments and first-principles calculations. The kappa-Ga2O3 films were grown on sapphire and GaN on-sapphire by a mist chemical vapor deposition. For kappa-Ga2O3 on sapphire grown at 650 degrees C, the beta-phase emerged upon the strain relaxation of the kappa-phase. Doping with Sn resulted in the thicker kappa-phase with the thinner beta-phase, suggesting the Sn-induced delay of strain relaxation. The phase stabilization can be attributed to the compressive strain induced by Sn substituting smaller Ga. This compressive strain also led to the thinner intermediate layers underneath the kappa-phase. kappa-Ga2O3 on GaN grown at 670 degrees C, on the other hand, exhibited neither the intermediate layers nor the beta-phase layer on top. In comparison with the undoped kappa-Ga2O3 on GaN, the Sn-doped sample showed a more abrupt interface with less severe rotational-domain formation. Our first-principles calculations based on density functional theory suggested that Sn+ on a pentahedral Ga site has the lowest formation energy under the oxygen-rich condition and maintains relatively low formation energy even under the oxygen-poor condition. Given the pentahedron coordination is unique to the kappa-phase, this could have also contributed to the phase stabilization. Understanding the effect of Sn could provide ways to improve the structural quality of kappa-Ga2O3, which is a promising material for next-generation electronics. Please check and confirm the edit made in article title.ConfirmedPlease confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 1 Given name: [Ha Young] Last name [Kang] Author 4 Given name: [Tae Hoon] Last name [Lee], Author 1 Given name: [Roy Byung Kyu] Last name [Chung]. Also, kindly confirm the details in the metadata are correct.ConfirmedPlease confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 1 Given name: [specify authors given name] Last name [specify authors last name]. Also, kindly confirm the details in the metadata are correct.Confirmed | Kang, Ha Young; Choi, Yoonho; Pyeon, Kyungjin; Lee, Tae Hoon; Chung, Roy Byung Kyu | Kyungpook Natl Univ, Elect Mat Sci & Engn Dept, Daegu 41566, South Korea | Lee, Tae/B-1160-2013 | 57346636700; 55685936600; 57955380200; 55731221000; 16642183100 | thl@knu.ac.kr;roy.b.chung@knu.ac.kr; | JOURNAL OF MATERIALS SCIENCE | J MATER SCI | 0022-2461 | 1573-4803 | 57 | 42 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2022 | 4.5 | 37.6 | 0.73 | 2025-06-25 | 8 | 10 | SI | Calculations; Chemical vapor deposition; Density functional theory; Gallium nitride; III-V semiconductors; Oxygen; Semiconductor doping; Stabilization; Stress relaxation; Chemical vapour deposition; Compressive strain; Experimental investigations; First principle calculations; Formation energies; Intermediate layers; Phase stabilization; Sn doping; Strain induced; Theoretical investigations; Sapphire | English | 2022 | 2022-11 | 10.1007/s10853-022-07897-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Improved Image Analysis for Measuring Gastric Ulcer Index in Animal Models and Clinical Diagnostic Data | Gastric ulcers are one of the most common gastrointestinal diseases. In this study, as an attempt to reduce the minimal error in clinical observations during the diagnosis of gastric ulcers, the applicability of improved ImageJ analysis (IA) was investigated by comparing the results of animal experiments and clinical data. As a result, IA exhibited a significantly improved potential for determining the ulcer index (UI) of clinical data sheets compared to those rated directly by conventional clinical observation (CCO). This indicated that IA enhanced the reproducibility of the measurement of gastric UI using a Bland-Altman plot, resulting in a reduced deviation of each UI value. In addition, it was confirmed that errors in gastric UI decisions can be reduced by adjusting RGB values in diagnostic clinical data (i.e., adjusting to 100 is relatively better than adjusting to 50 or 200). Together, these results suggest that the new enhanced IA could be compatible with novel applications for measuring and evaluating gastric ulcers in clinical settings, meaning that the developed method could be used not only as an auxiliary tool for CCO, but also as a pipeline for ulcer diagnosis. | Yoo, Chi-Yeol; Son, Hyeong-U; Kim, Sung-kook; Kim, Si-Oh; Lee, Sang-Han | Kyungpook Natl Univ, Grad Sch, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Dept Gastroenterol & Hepatol, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Anesthesiol, Daegu 41404, South Korea | Kwak, Sang Gyu/AAG-4341-2021; Lee, Seung Eun/ABG-1607-2021 | 57201151911; 53881847500; 34770060400; 7601585407; 57221453703 | yousee0581@knu.ac.kr;shwcrystal@naver.com;skkim@knu.ac.kr;sokim@knu.ac.kr;sang@knu.ac.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 0.8 | 2025-06-25 | 5 | 6 | gastric ulcer; image analysis; ImageJ; conventional clinical observation; ulcer index | WATER-IMMERSION; NITRIC-OXIDE; STRESS; PHOTOGRAPHY; PREVENTION; PROTECTION; FRACTION; COLOR | conventional clinical observation; gastric ulcer; image analysis; ImageJ; ulcer index | animal experiment; animal model; animal tissue; Article; clinical observation; controlled study; deep learning; diagnostic accuracy; diagnostic error; disease classification; erythema; image analysis; image processing; light intensity; male; mouse; nonhuman; photography; stomach lesion; stomach ulcer; ulcer index | English | 2022 | 2022-05 | 10.3390/diagnostics12051233 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Multiplex Immunofluorescence Assay of Infiltrating Mononu-Clear Cell Subsets in Acute T-Cell-Mediated Rejection and BK Virus-Associated Nephropathy in the Allograft Kidney | Renal allograft biopsy is the gold standard procedure for diagnosis of kidney rejection via specific pathological changes. To provide a better assessment of immunologic events in acute T-cell-mediated rejection (acute TCMR) and BK virus-associated nephropathy (BKVAN) cases, we used multiplex immunofluorescence staining to identify infiltrating mononuclear cell subsets in the cortex area of transplanted kidneys. Antibodies to CD4, CD8, CD20, CD68, Foxp3, and cytokeratin were used. In cortical interstitium, CD8+ cells were significantly more prevalent in acute TCMR than BKVAN cases (34% vs. 22.8%, p = 0.034). In medulla, CD20+ cells were significantly more prevalent in BKVAN than acute TCMR cases (51.9% vs. 11.3%, p = 0.028). | Kim, Mee-Seon; Lim, Jeong-Hoon; Han, Man-Hoon; Kim, Sang-Yeob; Kim, Yun Jae; Kim, Yong-Jin | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Div Nephrol,Dept Internal Med, Daegu 41944, South Korea; Univ Ulsan, Coll Med, Dept Convergence Med, Seoul 05505, South Korea; Asan Med Ctr, Seoul 05505, South Korea; Asan Med Ctr, Asan Inst Life Sci, Seoul 05505, South Korea | ; Kim, Yong-Jin/J-2745-2012; Lim, Jeong-Hoon/ABE-6003-2020 | 56123006700; 55360244300; 57194067936; 9232868900; 57221421363; 56150365500 | kimm2342@gmail.com;jh-lim@knu.ac.kr;one-many@hanmail.net;sykim3yk@amc.seoul.kr;windkim87@gmail.com;yyjjkim1@gmail.com; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 0.4 | 2025-06-25 | 2 | 3 | multiplex immunofluorescence assay; image analysis; T-cell-mediated rejection; BK virus-associated nephropathy; transplant kidney | MONOCLONAL-ANTIBODIES; RENAL MEDULLA; CLASSIFICATION; PROSPECTS | BK virus-associated nephropathy; Image analysis; Multiplex immunofluorescence assay; T-cell-mediated rejection; Transplant kidney | CD20 antigen; CD4 antigen; CD68 antigen; CD8 antigen; cytokeratin; transcription factor FOXP3; acute graft rejection; acute T-cell mediated rejection; adult; Article; BK virus nephropathy; CD8+ T lymphocyte; female; histopathology; human; human cell; human tissue; image analysis; image segmentation; immunofluorescence; immunofluorescence assay; immunohistochemistry; interstitium; kidney allograft; kidney biopsy; kidney graft; kidney medulla; kidney transplantation; male; middle aged; mononuclear cell; multiplex immunofluorescence assay; prevalence; regions of interest; Simian virus 40 | English | 2022 | 2022-02 | 10.3390/diagnostics12020268 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Noninvasive NMR/MRS Metabolic Parameters to Evaluate Metabolic Syndrome in Rats | (1) Background: Ectopic fat deposition and its effects, metabolic syndrome, have been significantly correlated to lifestyle and caloric consumption. There is no specific noninvasive evaluation tool being used in order to establish clinical markers for tracing the metabolic pathway implicated in obesity-related abnormalities that occur in the body as a result of a high-fat diet (HFD). The purpose of this work is to investigate in vivo ectopic fat distribution and in vitro metabolite profiles given by HFDs, as well as how they are inter-related, in order to find surrogate metabolic biomarkers in the development of metabolic syndrome utilizing noninvasive approaches. (2) Methods: Male Wistar rats were divided into a standard normal chow diet, ND group, and HFD group. After 16 weeks of different diet administration, blood samples were collected for proton nuclear magnetic resonance (H-1 NMR) and biochemical analysis. Magnetic resonance imaging/proton magnetic resonance spectroscopy (MRI/H-1 MRS) was performed on the abdomen, liver, and psoas muscle of the rats. (3) Results: Visceral fat showed the strongest relationship with blood cholesterol. Although liver fat content (LFC) was not associated with any biophysical profiles, it had the highest correlation with metabolites such as (-CH2)(n) very-low-density lipoprotein/low-density lipoprotein (VLDL/LDL), lactate, and N-acetyl glycoprotein of serum H-1 NMR. HFD showed no obvious influence on muscle fat accumulation. Acetoacetate, N-acetyl glycoprotein, lactate, (-CH2)(n) VLDL/LDL, and valine were the five possible metabolic biomarkers used to differentiate HFD from ND in the present study. (4) Conclusions: Our study has validated the influence of long-term HFD-induced ectopic fat on body metabolism as well as the metabolic profile deterioration both in vivo and in vitro. | Htun, Khin Thandar; Jaikumkao, Krit; Pan, Jie; Moe, Aye Thidar Moe; Intachai, Nuttawadee; Promsan, Sasivimon; Lungkaphin, Anusorn; Tapanya, Monruedee; Pasanta, Duanghathai; Tungjai, Montree; Kaewjaeng, Siriprapa; Kim, Hong Joo; Kaewkhao, Jakrapong; Lai, Christopher; Kothan, Suchart | Chiang Mai Univ, Fac Associated Med Sci, Ctr Radiat Res & Med Imaging, Dept Radiol Technol, Chiang Mai 50200, Thailand; Shandong Normal Univ, Coll Life Sci, Shandong Prov Key Lab Anim Resistant Biol, Jinan 250014, Peoples R China; Chiang Mai Univ, Fac Med, Dept Physiol, Chiang Mai 50200, Thailand; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Nakhon Pathom Rajabhat Univ, Fac Sci & Technol, Ctr Excellence Glass Technol & Mat Sci CEGM, Muang 73000, Nakhon Pathom, Thailand; Singapore Inst Technol, Hlth & Social Sci Cluster, 10 Dover Dr, Singapore 138683, Singapore | Lai, Christopher/A-3852-2014; Intachai, Nuttawadee/HOH-1735-2023; Kim, Hong Joo/AAE-1178-2022; Lai, Christopher Wai Keung/A-3852-2014; Jaikumkao, Krit/IUN-9587-2023 | 57221962831; 57189094453; 55733326300; 57221787142; 57221909427; 57189099082; 6504821056; 57190283815; 57205246803; 8518889700; 55871868200; 59051568100; 23974520300; 57189519251; 6507017165 | khinthandar_htun@cmu.ac.th;krit.ja@cmu.ac.th;jiepan@sdnu.edu.cn;ayethidarmoemoe@cmu.ac.th;nuttawadee.i@cmu.ac.th;sasivimon_promsan@cmu.ac.th;anusorn.lungka@cmu.ac.th;monruedee.t@cmu.ac.th;duanghathai.pas@cmu.ac.th;montree.t@cmu.ac.th;siriprapa.k@cmu.ac.th;hongjoo@knu.ac.kr;jakrapong@webmail.npru.ac.th;chris.lai@singaporetech.edu.sg;suchart.kothan@cmu.ac.th; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 7 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 0.53 | 2025-06-25 | 4 | 4 | MRI; H-1 MRS; H-1 NMR; HFD; metabolic syndrome | DIET-INDUCED OBESITY; SUBCUTANEOUS ADIPOSE-TISSUE; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; VISCERAL FAT; INTRAHEPATIC FAT; NMR; COMPLICATIONS; MUSCLE; MODEL | <sup>1</sup> H MRS; <sup>1</sup> H NMR; HFD; metabolic syndrome; MRI | acetoacetic acid; cholesterol; glycoprotein; lactic acid; low density lipoprotein; n acetyl glycoprotein; pentobarbital; unclassified drug; valine; very low density lipoprotein; abdomen; abdominal fat; adult; amino acid blood level; animal experiment; animal model; animal tissue; Article; biochemical analysis; body fat distribution; cholesterol blood level; controlled study; fat content; in vitro study; in vivo study; intra-abdominal fat; lactate blood level; lipid composition; lipid storage; lipoprotein blood level; liver; male; metabolic parameters; metabolic syndrome X; metabolite; non invasive procedure; nonhuman; nuclear magnetic resonance imaging; protein blood level; proton nuclear magnetic resonance; psoas muscle; rat; single drug dose | English | 2022 | 2022-07 | 10.3390/diagnostics12071621 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Editorial Material | Primary Clear Cell Carcinoma of the Pancreas: A Rare Case Report | Most pancreatic carcinoma is ductal adenocarcinoma. Primary pancreatic clear cell carcinomas composed almost entirely of clear tumor cells are very rare. We present a case of a 72-year-old man with a pancreatic mass, which was detected on abdominal computed tomography (CT). He had no symptoms and no abnormal findings on physical examination; however, he had a history of hepatitis B, hepatitis C, and hepatocellular carcinoma. He had received anti-viral treatment and radiofrequency ablation twice until 2 years prior. One year prior, follow-up contrast-enhanced abdominal CT revealed a newly developed pancreatic mass. Laparoscopic radical antegrade modular pancreato-splenectomy was performed. An ill-defined white-to-tan firm solid mass was observed in the pancreas, approximately 4.3 cm in diameter. The tumor cells showed >95% clear cell features, with a large round to oval nuclei and abundant clear cytoplasms, and well-defined cell membranes. Immunohistochemical staining revealed that the tumor cells were positive for cytokeratin 7, cytokeratin 19, HNF-1 beta, MUC-1, and p53. We excluded the possibility of metastatic clear renal cell carcinoma, neuroendocrine carcinoma, perivascular epithelioid cell tumor, malignant melanoma, and sarcoma because of the negativity for vimentin, chromogranin, synaptophysin, and HMB45. Consequently, he was diagnosed as having primary clear cell carcinoma of the pancreas and was treated with postoperative radiotherapy. Two months later, abdominal CT was suspicious for local recurrence at the resection margin. Additional adjuvant FOLFIRINOX chemotherapy was carried out 12 times. The patient is still alive after his third radiofrequency ablation for the newly-developed hepatic mass. Immunohistochemical staining for MUC-1 and HNF-1 beta, as well as histologic feature is very helpful for the diagnosis of primary pancreatic clear cell carcinoma with imaging methods for metastasis exclusion. | Kang, Yoo-Na | Kyungpook Natl Univ, Sch Med, Dept Forens Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea | 7402784356 | yoonakang@knu.ac.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 0.27 | 2025-06-25 | 1 | 2 | pancreas; primary; clear cell carcinoma; hepatitis; hepatocellular carcinoma | DUCTAL CARCINOMA; ADENOCARCINOMA; EXPRESSION; TUMOR | clear cell carcinoma; hepatitis; hepatocellular carcinoma; pancreas; primary | alanine aminotransferase; antivirus agent; aspartate aminotransferase; bilirubin; CA 19-9 antigen; creatinine; cytokeratin 19; cytokeratin 7; fluorouracil; folinic acid; hepatocyte nuclear factor 1beta; irinotecan; Ki 67 antigen; mucin 1; oxaliplatin; protein p53; triacylglycerol lipase; vimentin; abdominal radiography; aged; alanine aminotransferase blood level; Article; aspartate aminotransferase blood level; cancer combination chemotherapy; cancer radiotherapy; case report; clear cell carcinoma; clinical article; computer assisted tomography; contrast enhancement; follow up; hepatitis B; hepatitis C; human; immunohistochemistry; laparoscopic radical antegrade modular pancreato splenectomy; liver cell carcinoma; male; pancreas carcinoma; radiofrequency ablation; rare disease; splenectomy; surgical margin; tumor invasion | English | 2022 | 2022-09 | 10.3390/diagnostics12092046 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prognostic Impact of Myosteatosis on Mortality in Hospitalized Patients with COVID-19 | Body composition, including sarcopenia, adipose tissue, and myosteatosis, is associated with unfavorable clinical outcomes in patients with coronavirus disease (COVID-19). However, few studies have identified the impact of body composition, including pre-existing risk factors, on COVID-19 mortality. Therefore, this study aimed to evaluate the effect of body composition, including pre-existing risk factors, on mortality in hospitalized patients with COVID-19. This two-center retrospective study included 127 hospitalized patients with COVID-19 who underwent unenhanced chest computed tomography (CT) between February and April 2020. Using the cross-sectional CT images at the L2 vertebra level, we analyzed the body composition, including skeletal muscle mass, visceral to subcutaneous adipose tissue ratio (VSR), and muscle density using the Hounsfield unit (HU). Of 127 patients with COVID-19, 16 (12.6%) died. Compared with survivors, non-survivors had low muscle density (41.9 vs. 32.2 HU, p < 0.001) and high proportion of myosteatosis (4.5 vs. 62.5%, p < 0.001). Cox regression analyses revealed diabetes (hazard ratio [HR], 3.587), myosteatosis (HR, 3.667), and a high fibrosis-4 index (HR, 1.213) as significant risk factors for mortality in patients with COVID-19. Myosteatosis was associated with mortality in hospitalized patients with COVID-19, independent of pre-existing prognostic factors. | Kang, Min-Kyu; Lee, Yu-Rim; Song, Jeung-Eun; Kweon, Young-Oh; Tak, Won-Young; Jang, Se-Young; Park, Jung-Gil; Park, Soo-Young | Yeungnam Univ, Dept Internal Med, Coll Med, Daegu 42415, South Korea; Kyungpook Natl Univ, Dept Internal Med, Sch Med, Kyungpook Natl Univ Hosp, Daegu 41994, South Korea; Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu 42472, South Korea | Kang, Min Kyu/U-8050-2018; Park, Jung/AAK-5167-2020; Kang, Min/U-8050-2018 | 59142854300; 57194094753; 57189097150; 7004694832; 7004074582; 57202881977; 57216816399; 57191674344 | gsnrs@naver.com;psyoung0419@gmail.com; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 1.46 | 2025-06-25 | 9 | 11 | COVID-19; myosteatosis; visceral adiposity; sarcopenia; body composition | CORONAVIRUS DISEASE 2019; SARCOPENIA; MULTICENTER; OUTCOMES | body composition; COVID-19; myosteatosis; sarcopenia; visceral adiposity | adult; aged; Article; body composition; computer assisted tomography; controlled study; coronavirus disease 2019; density; diabetes mellitus; female; Fibrosis-4 Index; hospital patient; human; infection risk; intra-abdominal fat; major clinical study; male; mortality; mortality risk; muscle disease; muscle mass; obesity; prognosis; retrospective study; sarcopenia; second lumbar vertebra; skeletal muscle; steatosis; subcutaneous fat; survivor; thorax radiography | English | 2022 | 2022-09 | 10.3390/diagnostics12092255 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Simple Quantification of Surface Uptake in F-18 Florapronol PET/CT Imaging for the Validation of Alzheimer's Disease | We developed a novel quantification method named shape feature using F-18 florapronol positron emission tomography-computed tomography (PET/CT) and evaluated its sensitivity and specificity for discriminating between patients with Alzheimer's disease (AD) and patients with mild cognitive impairment or other precursors dementia (non-AD). We calculated the cerebral amyloid smoothing score (CASS) and brain atrophy index (BAI) using the surface area and volume of the region of interest in PET images. We calculated gray and white matter from trained CT data, prepared using U-net. Shape feature was calculated by multiplying CASS with BAI scores. We measured region-based standard uptake values (SUVr) and performed receiver operating characteristic (ROC) analysis to compare SUVr, shape feature, CASS, and BAI score. We investigated the relationship between shape feature and neuropsychological tests. Fifty subjects (23 with AD and 27 with non-AD) were evaluated. SUVr, shape feature, CASS, and BAI score were significantly higher in patients with AD than in those with non-AD. There was no statistically significant difference between shape feature and SUVr in ROC analysis. Shape feature correlated well with mini-mental state examination scores. Shape feature can effectively quantify beta-amyloid deposition and atrophic changes in the brain. These results suggest that shape feature is useful in the diagnosis of AD. | Kim, Do-Hoon; Son, Junik; Hong, Chae Moon; Ryu, Ho-Sung; Jeong, Shin Young; Lee, Sang-Woo; Lee, Jaetae | Kyungpook Natl Univ, Sch Med & Hosp, Dept Nucl Med, Daegu 41944, South Korea; Sch Med & Hosp, Dept Neurol, Daegu 41944, South Korea | Son, Junik/GVU-0832-2022; lee, sangwoo/KUD-1906-2024; Lee, Sang-Jun/A-3892-2015 | 55624468392; 57408265500; 37050876700; 57014206500; 36164032500; 57196249819; 7601451907 | k8016851@gmail.com;dr.dimiaru.jun@gmail.com;shahking@hanmail.net;ryuhosung138@gmail.com;syjeong@knu.ac.kr;swleenm@knu.ac.kr;aetae@knu.ac.kr;jaetae@knu.ac.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 0.4 | 2025-06-25 | 3 | 3 | beta-amyloid; positron emission tomography; F-18 florapronol; Alzheimer's disease; cerebral amyloid smoothing score; brain atrophy index | AMYLOID-BETA; HYPOTHETICAL MODEL; FLORBETAPIR-PET; BIOMARKERS; F-18-FC119S; AUTOPSY | Alzheimer’s disease; Beta-amyloid; Brain atrophy index; Cerebral amyloid smoothing score; F-18 florapronol; Positron emission tomography | amyloid beta protein; donepezil; fluorodeoxyglucose f 18; adult; aged; Alzheimer disease; Article; brain atrophy; cognitive defect; confidence interval; controlled study; dementia; diagnostic test accuracy study; female; gray matter; human; human experiment; image analysis; major clinical study; male; neuropsychological test; positron emission tomography-computed tomography; receiver operating characteristic; retina image; retrospective study; sensitivity and specificity; standardized uptake value; validation study; white matter | English | 2022 | 2022-01 | 10.3390/diagnostics12010132 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Strategic Significance of Low Viral Load of Human Papillomavirus in Uterine Cervical Cytology Specimens | Infection with high-risk (HR) Human Papillomavirus (HPV) is associated with the development of precancerous lesions or invasive carcinoma of the uterine cervix. Thus, the high viral load (VL) of HR-HPV DNA currently serves as a representative quantitative marker for cervical cancer. However, the clinical significance of low HPV DNA VL remains undetermined. This study aimed to evaluate the clinical association between the low HPV DNA VL and cytology/histologic diagnosis of cervical samples. We searched the electronic medical databases for the resultant analyses of HPV genotyping among patients who underwent treatment for any cervical lesion or who had undergone gynecological examinations with any positive HPV results according to the national cancer screening service between 2015 and 2016. HPV testing with genotyping and semi-quantitative VL measurement was conducted using an Anyplex(TM) II H28 Detection assay (H28 assay, Seegene, Seoul, Republic of Korea). The H28 assay is a multiplex semi-quantitative real-time PCR test using the tagging of oligonucleotide cleavage and extension (TOCE) technology. The VL was semi-quantified as high (3+; positive signal before 31 PCR cycles), intermediate (2+; positive between 31 and 39 PCR cycles), or low (1+; positive after 40 PCR cycles). Out of 5940 HPV VL analyses, 356 assays (5.99%) were reported as low VL (1+) of HPV DNA. Matched cytology diagnoses were mostly negative findings (n = 347, 97.5%), except for seven cases of atypical squamous cells of undetermined significance (1.9%) and two cases of atypical glandular cells (0.6%). During the follow-up periods, abnormal cytologic diagnoses were identified, including one case of high-grade squamous intraepithelial lesion (HSIL) and two low-grade squamous intraepithelial lesions (LSILs). The matched, confirmative histologic diagnosis of HSIL cytology was compatible with chronic inflammation, wherein the two LSILs had regular check-ups. None revealed clinically concerned outcomes associated with HPV-related squamous lesions. The cytology was most likely negative for malignancy when the VL of HPV DNA was low (1+). Additional strategic monitoring and management may thus be unnecessary. | Park, Nora Jee-Young; Park, Claire Su-Yeon; Jeong, Ji Yun; Kim, Moonsik; Yoo, Su Hyun; Chong, Gun Oh; Hong, Dae Gy; Park, Ji Young | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu 41404, South Korea; Kyungpook Natl Univ, Clin Omics Res Ctr, Sch Med, Daegu 41405, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, KNU Convergence Educ Program Biomed Sci Creat Fut, Daegu 41566, South Korea; Univ Alberta, Fac Nursing, Edmonton, AB T6G 2B7, Canada; Natl Police Hosp, Dept Pathol, Seoul 05715, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Obstet & Gynecol, Daegu 41404, South Korea | ; Park, Claire Su-Yeon/H-9665-2019 | 57226185359; 57193232078; 57205472984; 57195918515; 58963571400; 23099068000; 26656670100; 57210160197 | pathpjy@knu.ac.kr;clairesuyeonpark@gmail.com;jjiyun@gmail.com;teiroa83@gmail.com;sue-814@hanmail.net;gochong@knu.ac.kr;chssa0220@hanmail.net;jyparkmd@knu.ac.kr; | DIAGNOSTICS | DIAGNOSTICS | 2075-4418 | 12 | 8 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.6 | 37.6 | 0 | 2025-06-25 | 0 | 0 | Human Papillomavirus; HPV DNA; viral load; cervical cytology; shared decision making | II HPV HR; SQUAMOUS-CELL CARCINOMA; INTRAEPITHELIAL NEOPLASIA; CANCER; RISK; SITES; DNA; GENOTYPES; TRENDS; E2 | cervical cytology; HPV DNA; Human Papillomavirus; shared decision making; viral load | oligonucleotide; virus DNA; adult; Article; atypical squamous cells of the cervix; cancer screening; chronic inflammation; female; follow up; genotyping; gynecological examination; histopathology; human; major clinical study; middle aged; nonhuman; null result; real time polymerase chain reaction; squamous intraepithelial lesion of the cervix; uterine cervix cytology; virus load; Wart virus | English | 2022 | 2022-08 | 10.3390/diagnostics12081855 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | 3.0-Tesla MRI of normal canine adrenal glands | Adrenal disease is a common problem in dogs and MRI is increasingly being used as an adjunctive diagnostic test. To date, the MRI features of normal canine adrenal glands have only been reported using 1.5-Tesla (T) MRI. The aims of this prospective, methods-comparison, exploratory study were to evaluate the effects of pulse sequence on the appearance of normal canine adrenal glands using 3 Tesla MRI. Six research beagle dogs were sampled and the following pulse sequences were acquired for each: (1) T2-weighted images using two-dimensional (2D) turbo spin-echo (TSE), single-shot spin-echo (SSTSE), and three-dimensional (3D) TSE, (2) T1-weighted images using 2D TSE, 3D TSE, and 3D turbo field echo sequences, (3) post-contrast T1-weighted images, and (4) chemical shift imaging. The signal-to-noise ratio and contrast-to-noise ratio were measured for each dog and each pulse sequence. The signal intensity, clarity of the contour, distinction of the corticomedullary junction, degrees of motion, partial volume, and chemical shift artifact, and homogeneity of the contrast enhancement were evaluated qualitatively. In all sequences, except for chemical shift imaging, the adrenal glands were visualized in both planes with successful control of motion artifacts by manual ventilation. The adrenal contour was considered to be most clearly visualized with 2D TSE. Adrenal images were acquired within the shortest time using SSTSE although the contour was less clearly visualized than with TSE. Findings from this study in normal dogs can serve as background for further 3.0-T MRI studies of dogs with adrenal disease. | Lee, Eunji; Choi, Bo-kwon; Lee, Sang-kwon; Choi, Jihye | Chonnam Natl Univ, Coll Vet Med, Gwangju, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Seoul Natl Univ, Coll Vet Med, Dept Vet Med Imaging, Seoul 08826, South Korea | ; Lee, Sang-Kwon/IYI-9991-2023 | 57225178262; 57225173008; 56494541400; 7501393193 | imsono@snu.ac.kr; | VETERINARY RADIOLOGY & ULTRASOUND | VET RADIOL ULTRASOUN | 1058-8183 | 1740-8261 | 63 | 2 | SCIE | VETERINARY SCIENCES | 2022 | 1.7 | 37.8 | 1.09 | 2025-06-25 | 5 | 5 | 3.0-T; adrenal gland; dog; magnetic resonance imaging | MASSES; DIAGNOSIS | 3.0-T; adrenal gland; dog; magnetic resonance imaging | Adrenal Glands; Animals; Artifacts; Dogs; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Prospective Studies; Signal-To-Noise Ratio; alfaxalone; gadoterate meglumine; isoflurane; adrenal disease; adrenal gland; adult; anorexia; Article; computer assisted tomography; contrast enhancement; contrast to noise ratio; controlled study; depression; dexamethasone suppression test; dog; echo planar imaging; echography; exploratory research; female; image analysis; image quality; lymph node metastasis; male; nonhuman; nuclear magnetic resonance imaging; prospective study; proton nuclear magnetic resonance; signal noise ratio; vomiting; adrenal gland; animal; artifact; diagnostic imaging; procedures; three-dimensional imaging; veterinary medicine | English | 2022 | 2022-03 | 10.1111/vru.13066 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A suspected case of a multiple autoimmune syndrome in a poodle dog | A 9-year-old castrated male poodle dog was presented with icterus, anorexia, and lethargy. The dog was diagnosed with hypothyroidism 1 month before and was treated with levothyroxine. Severe anaemia with spherocytes, positive saline agglutination test, and hyperbilirubinemia indicated immune-mediated haemolytic anaemia (IMHA). Therefore, immunosuppressive therapy with prednisolone, mycophenolate mofetil, and danazol was started. Although the IMHA was well controlled, during tapering of prednisolone, acute multiple joint swelling and oedema suspected immune-mediated polyarthritis occurred twice. First, clinical symptoms improved as the dosage of prednisolone increased. However, the dog showed severe adverse effects to the steroid. Second time, we added leflunomide as another immunosuppressant, and clinical signs of arthritis disappeared. About 3 weeks later, despite the immunosuppressive therapy, skin lesions resembling an autoimmune dermatologic disorder spread throughout the body. Addition of cyclosporine resolved the skin lesions. This is a case report of a dog showing several sporadic clinical signs related to multiple autoimmune syndromes and their management using different immunosuppressant drugs. | Lim, Dahye; Jin, Yunseok; Son, Youngmin; Oh, Taeho; Bae, Seulgi | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, 80Daehak Ro, Daegu 41566, South Korea | 57216174038; 57411559400; 57226103101; 8251199600; 55418865900 | sgbae@knu.ac.kr; | VETERINARY MEDICINE AND SCIENCE | VET MED SCI | 2053-1095 | 8 | 2 | SCIE | VETERINARY SCIENCES | 2022 | 1.7 | 37.8 | 0.65 | 2025-06-25 | 2 | 4 | dog; immune-mediated haemolytic anaemia; immune-mediated polyarthritis; immunosuppressant; multiple autoimmune syndrome | DISEASES | dog; immune-mediated haemolytic anaemia; immune-mediated polyarthritis; immunosuppressant; multiple autoimmune syndrome | Anemia, Hemolytic, Autoimmune; Animals; Dog Diseases; Dogs; Immunosuppressive Agents; Male; Mycophenolic Acid; Prednisolone; Syndrome; antinuclear antibody; cefotaxime; clopidogrel; cyclosporine; danazol; doxycycline; famotidine; leflunomide; levothyroxine; lopirel; mycophenolate mofetil; prednisolone; rheumatoid factor; sucralfate; thyrotropin; immunosuppressive agent; mycophenolic acid; prednisolone; agglutination test; alopecia; Anaplasma; anorexia; Article; autoimmune disease; autoimmune hemolytic anemia; Babesia; bacterial arthritis; blood smear; blood transfusion; edema; Ehrlichia; erythrocyte disorder; fever; hematocrit; Hepatozoon; hyperbilirubinemia; hypothyroidism; immunosuppressive treatment; jaundice; joint swelling; Leptospira; lethargy; leukocytosis; Malassezia; nonhuman; polyarthritis; polymerase chain reaction; poodle; skin defect; spherocytosis; splenomegaly; systemic lupus erythematosus; ultrasound; animal; autoimmune hemolytic anemia; case report; dog; dog disease; male; pathology; syndrome; veterinary medicine | English | 2022 | 2022-03 | 10.1002/vms3.741 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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