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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Analysis of the Extracellular Proteome of Colistin-Resistant Korean Acinetobacter baumannii Strains | We analyzed the extracellular proteome of colistin-resistant Korean Acinetobacter baumannii (KAB) strains to identify proteome profiles that can be used to characterize extensively drug-resistant KAB strains. Four colistin-resistant KAB strains with colistin resistance associated with point mutations in pmrB and pmrC genes were analyzed. Analysis of the extracellular proteome of these strains revealed the presence of 506 induced common proteins, which were hence considered as the core extracellular proteome. Class C ADC-30 and class D OXA- 23 beta-lactamases were abundantly induced in these strains. Porins (Caro and CarO-like porin), outer membrane proteins (OmpH and BamABDE), transport protein (AdeK), receptor (TonB), and several proteins of unknown function were among the specifically induced proteins. Based on the sequence homology analysis of proteins from the core proteome and those of other A. baumannii strains and pathogenic bacterial species as well as further in silico screening, we propose that CarO-like porin is an A. baumannii-specific protein and that two tryptic peptides that originate from CarO-like porin detected by tandem mass spectrometry are peptide makers of this protein. | Lee, Sang-Yeop; Yun, Sung Ho; Lee, Hayoung; Yi, Yoon-Sun; Park, Edmond Changkyun; Kim, Wooyoung; Kim, Hye-Yeon; Lee, Je Chul; Kim, Gun-Hwa; Kim, Seung Il | Korea Basic Sci Inst, Res Ctr Bioconvergence Anal, Ochang 28119, South Korea; Korea Res Inst Chem Technol, Ctr Convegent Res Emerging Virus Infect, Daejeon 34114, South Korea; Univ Sci & Technol, Dept Bioanalyt Sci, Daejeon 34113, South Korea; Korea Basic Sci Inst, Ctr Res Equipment, Ochang 28119, South Korea; Chungnam Natl Univ, Coll Pharm, Dept Toxicol, Daejeon 34134, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea | ; LEE, HAYOUNG/HJJ-6600-2023 | 57203597099; 36828356500; 57200636136; 57189587992; 8356827900; 59062768500; 56002614500; 25930392000; 36747896000; 57206876176 | ksi@kbsi.re.kr; | ACS OMEGA | ACS OMEGA | 2470-1343 | 5 | 11 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2020 | 3.512 | 43.5 | 0.55 | 2025-06-25 | 13 | 12 | ANTIMICROBIAL RESISTANCE; IDENTIFICATION; VESICLES | English | 2020 | 2020-03-24 | 10.1021/acsomega.9b03723 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Characterization and Application of a Recombinant Exolytic GH50A β-Agarase from Cellvibrio sp. KY-GH-1 for Enzymatic Production of Neoagarobiose from Agarose | Neoagarobiose (NA2) is the repeating disaccharide unit of agarose and possesses various promising biological activities. To identify an efficient exolytic beta-agarase required for NA2 production from agarose, the GH50A beta-agarase gene from agar-degrading Cellvibrio sp. KY-GH-1 was overexpressed as a recombinant His-tagged protein using the Escherichia coli expression system. GH50A beta-agarase that consists of 797 amino acids was able to produce predominantly NA2 from agarose at an optimal temperature and pH of 35 degrees C and 7.5, respectively. The enzyme was stable up to 35 degrees C and within a pH range of 7.0-9.0. The K-m, V-max, K-cat, and k(cat)/K-m values of the enzyme were 26.5 mg/mL, 16.9 U/mg, 25.2 and 1.2 X 10(5) s(-1) M-1, respectively. The copresence of 5 mM MnSO4 and 10 mM tris(2-carboxyethyl)-phosphine (TCEP) resulted in a 2.5-fold enhancement of the enzyme activity. For NA2 production, neoagaro-oligosaccharides (NAOSs) containing NA4-NA18 were preferred over agarose or agaro-oligosaccharides (AOSs) as substrates. NA2 was produced along with minor amounts of agarotriose (A3) after treatment of AOS with the enzyme, indicating that the exolytic digestion of AOS by the enzyme was initiated by releasing A3 from nonreducing ends. Enzymatic hydrolysis of 0.4% agarose (100 mL) using GH50A beta-agarase (20 mu g/mL) for 4 h under optimal reaction conditions (5 mM MnSO4, 10 mM TCEP, 35 degrees C, 20 mM Tris-HCl, and pH 7.5) and purification of NA2 from hydrolysis products by Bio-Gel P-2 column chromatography resulted in the recovery of 216 mg of NA2 (similar to 54% yield from agarose). Altogether, these results suggest that the recombinant GHSOA beta-agarase is useful to convert agarose to NA2. | Kwon, MiJung; Jang, Won Young; Kim, Geon Min; Kim, Young Ho | Kyungpook Natl Univ, Lab Immunobiol, Sch Life Sci & Biotechnol, Coll Nat Sci, Daegu 41566, South Korea | 57208820636; 56373427000; 57220159933; 57208312159 | ykim@knu.ac.kr; | ACS OMEGA | ACS OMEGA | 2470-1343 | 5 | 45 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2020 | 3.512 | 43.5 | 0.55 | 2025-06-25 | 13 | 13 | English | 2020 | 2020-11-17 | 10.1021/acsomega.0c04390 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Development of an Antiwindup Technique for a Cascade Control System | A cascade control system comprising the primary and secondary controllers suffers from a cascade-type integral windup problem in which the output saturation of the secondary control loop can considerably increase the integral part of the primary control loop. In this paper, we present a new predictive antiwindup technique that can completely eliminate the possibility of secondary controller output saturation, resulting in no cascade-type integral windup phenomenon. The proposed method does not require any type of process models; thus, its implementation is simple and straightforward, which is a very favorable advantage compared to the model-based antiwindup techniques from the practical viewpoint. Our simulation confirms that the proposed method can completely remove the primary controller's cascade-type integral windup resulting from the saturation of the secondary controller output. Further, the proposed method exhibited good control performance without needing any type of process model for the various types of processes and controllers. Our experimental study successfully demonstrated that there are no problems in applying the proposed method to real plants. | Bae, Jeong Eun; Kim, Kyeong Hoon; Chu, Syng Chul; Heo, Jaepil; Lim, Sanghun; Sung, Su Whan | Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea | 57218849373; 57195755639; 57218852891; 57217335552; 57218849821; 7202731867 | suwhansung@knu.ac.kr; | ACS OMEGA | ACS OMEGA | 2470-1343 | 5 | 50 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2020 | 3.512 | 43.5 | 0.12 | 2025-06-25 | 3 | 5 | RESPONSE IDENTIFICATION METHOD; FRAMEWORK | English | 2020 | 2020-12-22 | 10.1021/acsomega.0c04927 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Real-Time Optimization of a CO Preferential Oxidation Reactor Temperature with Extremum Seeking Control Techniques | A hydrogen (H-2)-rich gas mixture is used as the fuel of the proton exchange membrane fuel cell (PEMFC). A small amount of the carbon monoxide (CO) gas in the gas mixture can significantly deactivate the catalyst of the PEMFC, resulting in a reduction in the efficiency of power generation. Preferential oxidation is used to reduce the CO concentration less than 10 ppm in the gas mixture. It has an optimal reaction temperature at which the reaction shows the minimum exit CO concentration with minimum consumption of H-2. This optimal temperature continuously changes under the varying conditions of operation and catalyst deactivation. In this study, two modified extremum seeking control (ESC) methods were proposed to continuously seek and maintain this optimal reaction temperature, guaranteeing CO concentration under 10 ppm even under time-varying conditions. The proposed methods have a smaller number of design parameters than the conventional extremum seeking approaches so that tuning the ESC method is much easier, more intuitive, and efficient. In addition, the proposed method can additionally use the secondary measurement to improve the performance of the ESC method by removing the possibility that the modeling error of the linear dynamic block can deteriorate the accuracy of calculating the gradient of the nonlinear static block. The experimental results confirmed that the proposed methods can track the optimal temperature within a short time compared to the conventional approach while successfully maintaining the CO concentration below 10 ppm. | Heo, Jea Pil; Sung, Su Whan; Lee, Jietae | Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea | 57189221315; 7202731867; 7601455194 | jtlee@knu.ac.kr; | ACS OMEGA | ACS OMEGA | 2470-1343 | 5 | 23 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2020 | 3.512 | 43.5 | 0.12 | 2025-06-25 | 3 | 3 | OXIDE CATALYST; CUO-CEO2; SYSTEMS | English | 2020 | 2020-06-16 | 10.1021/acsomega.0c01145 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Synthesis of Metal-Organic Framework ZnOx-MOF@MnO2 Composites for Selective Removal of Strontium Ions from Aqueous Solutions | A Zn(II)-based metal-organic framework (MOF) compound and MnO2 were used to prepare ZnOx-MOF@MnO2 composites for selective Sr2+ removal in aqueous solutions. The ZnOx-MOF@MnO2 composites were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and Brunauer-Emmett-Teller surface area analysis. The functional groups, morphologies, thermal stabilities, and specific surface areas of the composites were suitable for Sr2+ adsorption. A maximum adsorption capacity of 147.094 mg g(-1) was observed in batch adsorption experiments, and the sorption isotherms were fit well by the Freundlich model of multilayer adsorption. Adsorption reached equilibrium rapidly in kinetic experiments and followed the pseudo-secondorder kinetic model. The adsorption capacity of the ZnOx-MOF@MnO2 composite with the highest MnO2 content was high over a wide pH range, and the composite was highly selective toward Sr2+ in solutions containing coexisting competing ions. Also, it has a good reusability for removing Sr2+. | Choi, Jung-Weon; Park, Yoon-Ji; Choi, Sang-June | Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, Daegu 41566, South Korea | 56996378900; 57209361847; 56605563600 | sjchoi@knu.ac.kr; | ACS OMEGA | ACS OMEGA | 2470-1343 | 5 | 15 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2020 | 3.512 | 43.5 | 1.59 | 2025-06-25 | 37 | 40 | MANGANESE OXIDE; ADSORPTION; ADSORBENT; PERFORMANCE; EFFICIENT; SORPTION; CESIUM; MEMBRANE; RECOVERY; SR(II) | English | 2020 | 2020-04-21 | 10.1021/acsomega.0c00228 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Well-Designed Au Nanorod-Doped Cu2O Core-Shell Nanocube-Embedded Reduced Graphene Oxide Composite for Efficient Removal of a Water Pollutant Dye | To ensure environmental safety, the removal of organic pollutants has gained increasing attention globally. We have synthesized uniform Au nanorod (NR)-doped Cu2O core-shell nanocubes (CSNCs) via a seed-mediated route embedded on the surface of rGO sheets. The Au NRs@Cu2O/rGO nanocomposite was characterized using various techniques such as transmission electron microscopy (TEM), atomic force microscopy (AFM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier-transform infrared (FT-IR) and Raman spectroscopies. The scanning TEMenergy-dispersive spectroscopy (STEM-EDS) elemental mapping of the AuNRs@Cu2O/rGO nanocomposite indicates that the Au NR (40 nm) is fully covered with the Cu2O particles (similar to 145 nm) as a shell. N-2 gas sorption analysis shows that the specific surface area of the composite is 205.5 m(2)/g with a mesoporous character. Moreover, incorporation of Au NRs@Cu2O CSNCs increases the nanogaps around the nanoparticles and suppresses the stacking/bundling of rGO, which significantly influences the pore size and increase the surface area. A batch adsorption experiment was carried out under various parameters, such as the effect of pH, contact time, temperature, initial dye concentration, and adsorbent dosage, for the removal of methylene blue (MB) in aqueous solution. The high surface area and mesoporosity can cause the adsorption capacity to reach equilibrium within 20 min with a 99.8% removal efficiency. Both kinetic and isotherm data were obtained and fitted very well with the pseudo-second-order kinetic and Langmuir isotherm model. The Langmuir isotherm revealed an excellent dye sorption capacity of 243.9 mg/g at 298 K. Moreover, after five adsorption cycles, the dye removal efficiency decreased from 99 to 86%. This novel route paves a new path for heterogeneous adsorbent synthesis, which is useful for catalysis and electrochemical applications. | Mahajan, Hansa; Arumugasamy, Shiva Kumar; Panda, Atanu; Sada, Venkateswarlu; Yoon, Minyoung; Yun, Kyusik | Gachon Univ, Dept Nanochem, Seongnam 13120, South Korea; Gachon Univ, Dept Bionanotechnol, Seongnam 13120, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Censer, Daegu 41566, South Korea | venkateswarlu, sada/P-2034-2018; Panda, Dr. Atanu/AAU-7780-2020 | 57202075318; 57212410431; 57201632042; 55649254900; 25222186500; 35331093900 | venkisada67@gmail.com;myyoon@knu.ac.kr;ykusik@gachon.ac.kr; | ACS OMEGA | ACS OMEGA | 2470-1343 | 5 | 38 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2020 | 3.512 | 43.5 | 0.67 | 2025-06-25 | 16 | 17 | METHYLENE-BLUE; CATIONIC DYES; AQUEOUS-SOLUTION; RECENT ADVANCEMENTS; ADSORPTION REMOVAL; FACILE SYNTHESIS; MALACHITE GREEN; METAL-IONS; ADSORBENT; NANOCOMPOSITES | English | 2020 | 2020-09-29 | 10.1021/acsomega.0c03487 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | A multi-centre study of trends in hepatitis B virus-related hepatocellular carcinoma risk over time during long-term entecavir therapy | The risk of developing hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) is reduced by antiviral therapy. Here, we evaluated the chronological trends in HCC development risk starting in 2007, when entecavir reimbursement was first initiated in South Korea. Treatment-naive patients with chronic hepatitis B (CHB) receiving entecavir 0.5 mg/d were stratified into three groups according to entecavir start time: early (2007-2010), middle (2011-2012) and late (2013-2014) cohorts Among 2442 patients, cumulative probabilities of developing HCC after 1, 3 and 5 years were, respectively, 1.7%, 5.1%, and 8.2% (early cohort; n = 672); 1.5%, 5.1% and 8.9% (middle cohort; n = 757); and 1.2%, 5.3% and 10.6% (late cohort; n = 1013;P > .05 between each pair). Older age, male, positive hepatitis B e antigen, liver cirrhosis, Child-Pugh class B (vs A) and lower platelet count significantly predicted HCC development in univariate analysis (P < .001), whereas entecavir start time (early vs middle vs late cohorts) did not affect the risk of HCC development (P = .457). A multivariate analysis revealed that older age (adjusted hazard ratio [aHR]=1.041), male gender (aHR = 2.069), liver cirrhosis (aHR = 3.771) and Child-Pugh class B (vs A, aHR = 1.548) were independently associated with an increased risk of HCC development, whereas higher platelet count was independently associated with a reduced risk of HCC development (aHR = 0.993; allP < .05). In conclusion, the risk of developing HCC among patients receiving entecavir in South Korea has been stable since 2007. To establish more effective HCC surveillance programs, further studies regarding the carcinogenic roles of nonviral factors are required. | Kim, Seung Up; Chon, Yong Eun; Seo, Yeon Seok; Lee, Hye Won; Lee, Han Ah; Kim, Mi Na; Min, In Kyung; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Tak, Won Young; Kim, Beom Kyung; Park, Soo Young | Yonsei Univ, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Yonsei Univ, Inst Gastroenterol, Coll Med, Seoul, South Korea; Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea; Cha Univ, Dept Internal Med, Cha Bundang Med Ctr, Seongnam, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Biomed Syst Informat, Biostat Collaborat Unit, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea | ; Ahn, Sang Hoon/AFM-2603-2022; Kim, Sun/L-4239-2013; Lee, Hye/D-9081-2016; Park, Jun/H-7127-2019; Kim, Yoon/G-6633-2015; Kim, Dong/F-4608-2014; SANG-HOON, AHN/AAV-2600-2020; Kim, Kyung/F-3470-2010; Kim, Eun Young/JCE-3602-2023 | 54933821200; 36089768300; 35234912400; 57200110315; 57190980926; 57202910894; 57215770167; 47861376300; 56119929100; 7401989551; 7004074582; 35302925200; 57191674344 | beomkkim@yuhs.ac;psyoung0419@gmail.com; | JOURNAL OF VIRAL HEPATITIS | J VIRAL HEPATITIS | 1352-0504 | 1365-2893 | 27 | 12 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;INFECTIOUS DISEASES;VIROLOGY | 2020 | 3.728 | 43.6 | 0.21 | 2025-06-25 | 6 | 4 | carcinogenic; entecavir; hepatitis B virus; hepatocellular carcinoma; liver cirrhosis | LIVER FIBROSIS; MARKERS | carcinogenic; entecavir; hepatitis B virus; hepatocellular carcinoma; liver cirrhosis | Aged; Antiviral Agents; Carcinoma, Hepatocellular; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Retrospective Studies; Treatment Outcome; entecavir; hepatitis B(e) antigen; antivirus agent; entecavir; guanine; adult; aging; Article; cancer growth; cancer risk; Child Pugh score; chronic hepatitis B; cohort analysis; comparative study; disease association; female; health insurance; human; liver cell carcinoma; liver cirrhosis; long term care; major clinical study; male; middle aged; multicenter study; platelet count; prediction; priority journal; retrospective study; risk reduction; sex ratio; South Korea; aged; clinical trial; complication; Hepatitis B virus; liver cell carcinoma; liver cirrhosis; liver tumor; treatment outcome | English | 2020 | 2020-12 | 10.1111/jvh.13384 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Predictive score for hepatocellular carcinoma after hepatitis B e antigen loss in patients treated with entecavir or tenofovir | The risk of developing hepatocellular carcinoma (HCC) after hepatitis B e antigen seroclearance (ESC) remains unclear. We established and validated a new risk prediction model for HCC development after ESC in patients with chronic hepatitis B (CHB) receiving antiviral therapy (AVT). Between 2006 and 2016, 769 patients (training cohort) and 1,061 patients (validation cohort) with CHB who experienced ESC during AVT using entecavir (ETV) or tenofovir disoproxil fumarate (TDF) were recruited. In the multivariate analysis, male sex (hazard ratio [HR] = 2.092; 95% confidence interval [CI] = 1.152-3.800), cirrhosis (HR = 5.141; 95% CI = 2.367-11.167) and fibrosis-4 index (FIB-4) of >3.25 (HR = 2.070; 95% CI = 1.184-3.620) were the independent risk factors for HCC development (all P 3.25 = 1, 3.25 as constituent variables. | Lim, Tae Seop; Lee, Hyun Woong; Lee, Jung Il; Kim, In Hee; Lee, Chang Hun; Jang, Byoung Kuk; Chung, Woo Jin; Yim, Hyung Joon; Suh, Sang Jun; Seo, Yeon Seok; Lee, Han Ah; Yu, Jung Hwan; Lee, Jin-Woo; Kim, Sang Gyune; Kim, Young Seok; Park, Soo Young; Tak, Won Young; Kim, Soon Sun; Cheong, Jae Youn; Jeong, Soung Won; Jang, Jae Young; Rou, Woo Sun; Lee, Byung Seok; Kim, Seung Up | Yonsei Univ, Yongin Severance Hosp, Dept Internal Med, Coll Med, Yongin, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Chonbuk Natl Univ, Dept Internal Med, Med Sch, Jeonju, South Korea; Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Korea Univ, Coll Med, Ansan Hosp, Dept Internal Med, Ansan, South Korea; Korea Univ, Coll Med, Anam Hosp, Dept Internal Med, Seoul, South Korea; Inha Univ, Dept Internal Med, Sch Med, Incheon, South Korea; Soonchunhyang Univ, Dept Internal Med, Bucheon Hosp, Coll Med, Bucheon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Ajou Univ, Dept Gastroenterol, Sch Med, Suwon, South Korea; Soonchunhyang Univ, Dept Internal Med, Coll Med, Seoul Hosp, Seoul, South Korea; Chungnam Natl Univ, Dept Internal Med, Sch Med, 266 Munwha Ro, Daejeon 301747, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea | ; LEE, HYUN/ABC-6119-2021; Kim, Sang/AAI-5704-2020; Jang, Jae/AAN-1508-2020; KIM, JEONGSEON/AAA-4643-2022; Lee, Jeong-Hoon/Q-1055-2018; Lee, Chang-Hun/B-7015-2019; Cheon, Jung-Eun/J-5684-2012; Kim, Sun/L-4239-2013 | 56518959700; 55509204800; 57190744199; 7404143744; 57203056004; 58849853600; 55741230500; 7005664934; 25723856600; 35234912400; 57190980926; 57893118300; 57216961138; 35278042500; 57207444475; 57191674344; 7004074582; 36056907800; 7004933299; 55625009600; 57221679776; 50562108200; 57203247116; 54933821200 | gie001@cnuh.co.kr;ksukorea@yuhs.ac; | JOURNAL OF VIRAL HEPATITIS | J VIRAL HEPATITIS | 1352-0504 | 1365-2893 | 27 | 10 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;INFECTIOUS DISEASES;VIROLOGY | 2020 | 3.728 | 43.6 | 0.36 | 2025-06-25 | 7 | 7 | hepatitis B; hepatitis B e antigen; hepatocellular carcinoma; risk prediction | DISOPROXIL FUMARATE; LIVER STIFFNESS; RISK; FIBROSIS; FIB-4; VALIDATION; EVENTS; LEVEL | hepatitis B; hepatitis B e antigen; hepatocellular carcinoma; risk prediction | Antiviral Agents; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Tenofovir; entecavir; hepatitis B(e) antigen; tenofovir disoproxil; antivirus agent; entecavir; guanine; hepatitis B(e) antigen; tenofovir; adult; antiviral therapy; Article; cancer growth; cancer risk; chronic hepatitis B; cohort analysis; controlled study; female; human; human cell; liver cell carcinoma; liver cirrhosis; liver fibrosis; major clinical study; male; mathematical model; predictive value; priority journal; retrospective study; sex ratio; complication; liver cell carcinoma; liver tumor | English | 2020 | 2020-10 | 10.1111/jvh.13316 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effectiveness of Gelatin-Thrombin Matrix Sealants (Floseal®) on Postoperative Spinal Epidural Hematoma during Single-Level Lumbar Decompression Using Biportal Endoscopic Spine Surgery: Clinical and Magnetic Resonance Image Study | Background. Symptomatic postoperative spinal epidural hematoma (PSEH) is a devastating complication that could develop after lumbar decompression surgery. PSEH can also develop after biportal endoscopic spine surgery (BESS), one of the recently introduced minimally invasive spine surgery techniques. Gelatin-thrombin matrix sealant (GTMS) is commonly used to prevent PSEH. This study aimed at analyzing the clinical and radiological effects of GTMS use during BESS. Methods. A total of 206 patients with spinal stenosis who underwent decompression by BESS through a posterior interlaminar approach from October 2015 to September 2018 were enrolled in this study. Postoperative magnetic resonance imaging (MRI) was performed in all patients for evaluation of PSEH. Patients in whom GTMS was not used during surgery were assigned to Group A, and those in whom GTMS was used were classified as Group B. In the clinical evaluation, the visual analog scale (VAS) of the leg and back, Oswestry Disability Index (ODI), and modified MacNab criteria were used. The incidence rate and degree of dural compression of PSEH on postoperative MRI were measured. Results. The average age of the patients was 68.1 +/- 11.2(42-89) years. The overall incidence rate of PSEH was 20.9% (43/206). The incidence rates in Groups A and B were 26.4% and 13.6%, respectively, showing a significant difference (p=0.023). The VAS-leg and ODI improvement was significantly different depending on the intraoperative use of GTMS. However, there was no statistically significant difference between the two groups in terms of the VAS-back improvement. Groups A and B showed "good" and "excellent" rates according to the modified MacNab criteria in 79.4% and 87.6% of patients, respectively, showing statistically significant difference (p=0.049). In Group A, two patients underwent revision surgery due to PSEH, while none in Group B had such event. Conclusion. Intraoperative use of GTMS during BESS may be related to reduction in the occurrence rate of PSEH. Specifically, patients with GTMS appliance showed marked decrease in the occurrence of PSEH and had better clinical outcomes. | Kim, Ju-Eun; Yoo, Hyun-Seung; Choi, Dae-Jung; Park, Eugene J.; Hwang, Jin-Ho; Suh, Jeong-Duk; Yoo, Jun-Hyug | Himnaera Hosp, Dept Orthoped Surg, Busan, South Korea; Daegu Fatima Hosp, Dept Orthoped Surg, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Orthoped Surg, Daegu, South Korea | ; Park, Eugene/P-1473-2018 | 56487007900; 57217302438; 57061435000; 55371642100; 57202433383; 57218265155; 57218270562 | dspfuture@hanmail.net;brianyoo82@naver.com;djchoi9@hanmail.net;cnuhos55@hotmail.com;osjinho@naver.com;nurface24@gmail.com;108631@naver.com; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2020 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2020 | 3.411 | 43.7 | 1.06 | 2025-06-25 | 28 | 26 | RADIOLOGICAL OUTCOMES; FIBROSIS; LAMINECTOMY; HEMOSTASIS; STENOSIS; RISK | Aged; Aged, 80 and over; Decompression, Surgical; Endoscopy; Female; Gelatin; Hematoma, Epidural, Spinal; Humans; Lumbar Vertebrae; Magnetic Resonance Imaging; Male; Middle Aged; Postoperative Complications; Reoperation; Thrombin; Treatment Outcome; gelatin; gelatin thrombin matrix sealant; sealant; thrombin; unclassified drug; gelatin; thrombin; adult; aged; Article; back; biportal endoscopic spine surgery; clinical effectiveness; clinical evaluation; clinical outcome; controlled study; endoscopic surgery; female; human; incidence; leg; lumbar spinal cord; lumbar spinal stenosis; major clinical study; male; nuclear magnetic resonance imaging; Oswestry Disability Index; postoperative complication; reoperation; spinal cord decompression; spinal hematoma; spine surgery; surgical approach; visual analog scale; decompression surgery; diagnostic imaging; endoscopy; lumbar vertebra; middle aged; postoperative complication; spinal hematoma; surgery; treatment outcome; very elderly | English | 2020 | 2020-07-09 | 10.1155/2020/4801641 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Histone Deacetylase Inhibition Attenuates Aortic Remodeling in Rats under Pressure Overload | The use of histone deacetylase (HDAC) inhibitor is a novel therapeutic strategy for cardiovascular disease. Studies have shown that many HDAC inhibitors have the ability to reduce the aortic remodeling in various animal models. We hypothesized that the HDAC inhibitor, MGCD0103 (MGCD), attenuates aortic remodeling in rats under pressure overload-induced by transverse aortic constriction (TAC). The aortic ring tension analysis was conducted using the thoracic aorta. Sections of the aorta were visualized after hematoxylin and eosin, trichrome, and Verhoeff-van Gieson staining, and immunohistochemistry. The expression of genes related to aortic remodeling (alpha SMA,Mmp2, andMmp9) and angiotensin receptors (Agtr1andAgtr2) was determined by quantitative real-time polymerase chain reaction. There was a significant decrease in relaxation of the aorta when treated with MGCD. Fibrosis of the aortic wall and expression of angiotensin receptors increased in TAC rats, which was attenuated by MGCD. These results indicate that MGCD, an HDAC inhibitor, attenuates aortic remodeling in rats with TAC-induced pressure overload rats and may serve as a potential therapeutic target of antiaortic remodeling in pressure overload-induced hypertension-related diseases. | Jung, Hanna; Lee, Eunjo; Kim, Inkyeom; Kim, Gun Jik | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Thorac & Cardiovasc Surg, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, PBK21 PLUS KNU Biomed Convergence Program, Daegu 41944, South Korea | Jung, Hanna/Y-4165-2019 | 56467570700; 57190980166; 7404144630; 22234444300 | straightroot@knu.ac.kr; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2020 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2020 | 3.411 | 43.7 | 0.12 | 2025-06-25 | 5 | 4 | ANGIOTENSIN-II; ANEURYSM; MOCETINOSTAT; CONSTRICTION; LOSARTAN; FIBROSIS; RECEPTOR; HDACS; MODEL | Animals; Aorta; Constriction, Pathologic; Gene Expression Regulation; Histone Deacetylase Inhibitors; Hypertension; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley; Vascular Remodeling; alpha smooth muscle actin; angiotensin 1 receptor; angiotensin 2 receptor; gelatinase A; gelatinase B; histone deacetylase; mocetinostat; histone deacetylase inhibitor; animal experiment; animal model; animal tissue; aorta; aortic constriction; aortic disease; aortic wall; aortic wall fibrosis; Article; blood pressure measurement; controlled study; enzyme inhibition; gene expression; heart left ventricle overload; hypertension; immunohistochemistry; male; mRNA expression level; nonhuman; rat; real time polymerase chain reaction; thoracic aorta; transverse aortic constriction; vascular fibrosis; vasodilatation; animal; drug effect; gene expression regulation; hypertension; metabolism; pathology; Sprague Dawley rat; stenosis, occlusion and obstruction; vascular remodeling | English | 2020 | 2020-07-25 | 10.1155/2020/4705615 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Impact of Matching Point Selections on Image Registration Accuracy between Optical Scan and Computed Tomography | The point-based surface registration method involves the manual selection process of paired matching points on the data of computed tomography and optical scan. The purpose of this study was to investigate the impact of selection error and distribution of fiducial points on the accuracy of image matching between 3-dimensional (3D) images in dental planning software programs. Computed tomography and optical scan images of a partial edentulous dental arch were obtained. Image registration of the optical scan image to computed tomography was performed using the point-based surface registration method in planning software programs under different conditions of 3 fiducial points: point selection error (0, 1, or 2 mm), point distribution (unilateral, bilateral), and planning software (Implant Studio, Blue Bio Plan) (n=5per condition,N=60). The accuracy of image registration at each condition was evaluated by measuring linear discrepancies between matched images at X,Y, and Z axes. Kruskal-Wallis test, Mann-WhitneyUtest with Bonferroni correction, and 3-way analysis of variance were used to statistically analyse the measurement data (alpha=0.05). No statistically significant difference was exhibited between the 0 and 1 mm point mismatch conditions in either unilateral or bilateral point distributions. The discrepancy values in the 2 mm mismatch condition were significantly different from the other mismatch conditions, especially in the unilateral point distribution (P<0.05). Strong interactions among point selection error, distribution, and software programs on the image registration were found (P<0.001). Minor matching point selection error did not influence the accuracy of point-based automatic image registration in the software programs. When the fiducial points are distributed unilaterally with large point selection error, the image matching accuracy could be decreased. | Mai, Hai Yen; Lee, Du-Hyeong | Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, 2177 Dalgubeoldae Ro, Daegu 41940, South Korea; Kyungpook Natl Univ, Inst Translat Res Dent, Daegu 41940, South Korea | 57217872800; 35770948000 | deweylee@knu.ac.kr; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2020 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2020 | 3.411 | 43.7 | 0.47 | 2025-06-25 | 12 | 13 | GUIDED IMPLANT-SURGERY; CONE-BEAM; DENTAL MODELS; CT; DENSITY; SKULL | Algorithms; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Optical Imaging; Radiography, Dental; Software; Tomography, X-Ray Computed; Article; computer assisted tomography; image registration; three-dimensional imaging; tooth arch; algorithm; comparative study; fluorescence imaging; human; image processing; procedures; software; tooth radiography; x-ray computed tomography | English | 2020 | 2020-08-05 | 10.1155/2020/3285431 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Influence of the Postcuring Process on Dimensional Accuracy and Seating of 3D-Printed Polymeric Fixed Prostheses | The postcuring process is essential for 3-dimensional (3D) printing of photopolymer-based dental prostheses. However, the deformation of prostheses resulting from the postcuring process has not been fully investigated. The purpose of this study was to evaluate the effects of different postcuring methods on the fit and dimensional accuracy of 3D-printed full-arch polymeric fixed prostheses. A study stone model with four prosthetic implant abutments was prepared. A full-arch fixed dental prosthesis was designed, and the design was transferred to dental computer-aided manufacturing (CAM) software in which supports were designed to the surface of the prosthesis design for 3D printing. Using a biocompatible photopolymer and a stereolithography apparatus 3D printer, polymeric prostheses were produced (N=21). In postcuring, the printed prostheses were polymerized in three different ways: the prosthesis alone, the prosthesis with supports, or the prosthesis on a stone model. Geometric accuracy of 3D-printed prostheses, marginal gap, internal gap, and intermolar distance was evaluated using microscopy and digital techniques. Kruskal-Wallis and Mann-Whitney U tests with Bonferroni correction were used for the comparison of results among groups (alpha=0.05). In general, the mean marginal and internal gaps of cured prostheses were the smallest when the printed prostheses were cured with seating on the stone model (P<0.05). With regard to the adaptation accuracy, the presence of supports during the postcuring process did not make a significant difference. Error in the intermolar distance was significantly smaller in the model seating condition than in the other conditions (P<0.001). Seating 3D-printed prosthesis on the stone model reduces adverse deformation in the postcuring process, thereby enabling the fabrication of prostheses with favorable adaptation. | Kim, Jaewon; Lee, Du-Hyeong | Univ Buffalo, Sch Dent Med, Dept Periodont & Endodont, New York, NY USA; Kyungpook Natl Univ, Sch Dent, Inst Translat Res Dent, Dept Prosthodont, Daegu 41940, South Korea | 57207915082; 35770948000 | deweylee@knu.ac.kr; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2020 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2020 | 3.411 | 43.7 | 0.47 | 2025-06-25 | 13 | 16 | FIT; PHOTOPOLYMER; CONVERSION; FUTURE; CROWNS | Dental Prosthesis; Dental Prosthesis Design; Polymers; Printing, Three-Dimensional; polymer; Article; comparative study; computer aided manufacturing; data analysis software; dental light-curing; dimensional measurement accuracy; intermolar width; microscopy; polymerization; prosthesis design; stereolithography; stereomicroscopy; three dimensional printing; tooth occlusion; chemistry; tooth prosthesis | English | 2020 | 2020-11-16 | 10.1155/2020/2150182 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Learning Curve and Clinical Outcome of Biportal Endoscopic-Assisted Lumbar Interbody Fusion | Interbody fusion is a common surgical technique for diseases of the lumbar spine. Biportal endoscopic-assisted lumbar interbody fusion (BE-LIF) is a novel minimally invasive technique that has a long learning curve, which can be a barrier for surgeons. Therefore, we analyzed the learning curve in terms of operative time and evaluated the outcomes of BE-LIF. A retrospective study of fifty-seven consecutive patients who underwent BE-LIF for degenerative lumbar disease by a single surgeon from January 2017 to December 2018 was performed. Fifty patients underwent a single-level procedure, and 7 underwent surgery at two levels. The mean follow-up period was 24 months (range, 14-38). Total operative time, postoperative drainage volume, time to ambulation, and complications were analyzed. Clinical outcome was measured using the Oswestry Disability Index (ODI), Visual Analog Scale (VAS) score for back and leg pain, and modified Macnab criteria. The learning curve was evaluated by a nonparametric regression locally weighted scatterplot smoothing curve. Cases before the stable point on the curve were designated as group A, and those after the stable point were designated group B. Operative time decreased as the number of cases increased. A stable point was noticed on the 400th day and the 34th case after the first BE-LIF was performed. All cases showed improved ODI and VAS scores at the final follow-up. Overall mean operative time was 171.74 +/- 35.1 min. Mean operative time was significantly lower in group B (139.7 +/- 11.6 min) compared to group A (193.4 +/- 28.3 min). Time to ambulation was significantly lower in group B compared to group A. VAS and ODI scores did not differ between the two groups. BE-LIF is an effective minimally invasive technique for lumbar degenerative disease. In our case series, this technique required approximately 34 cases to reach an adequate performance level. | Kim, Ju-Eun; Yoo, Hyun-Seung; Choi, Dae-Jung; Hwang, Jin-Ho; Park, Eugene J.; Chung, Seungho | Himnaera Hosp, Dept Orthoped Surg, Busan, South Korea; Daegu Fatima Hosp, Dept Orthoped Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Orthoped Surg, Kyungpook Natl Univ Hosp, Daegu, South Korea | ; Park, Eugene/P-1473-2018 | 56487007900; 57217302438; 57061435000; 57202433383; 55371642100; 57221219695 | dspfuture@hanmail.net;brianyoo82@naver.com;djchoi9@hanmail.net;osjinho@naver.com;pjj841229@gmail.com;ho882243@gmail.com; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2020 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2020 | 3.411 | 43.7 | 1.94 | 2025-06-25 | 61 | 67 | BACK MUSCLE INJURY; SPINE SURGERY; RETRACTORS; DISABILITY; WORK | Aged; Clinical Competence; Endoscopy; Female; Humans; Learning Curve; Lumbar Vertebrae; Male; Middle Aged; Operative Time; Postoperative Complications; Retrospective Studies; Spinal Fusion; Treatment Outcome; adult; aged; Article; backache; biportal endoscopic assisted lumbar interbody fusion; clinical outcome; coccygeal vertebra; controlled study; endoscopic surgery; female; follow up; human; learning curve; leg pain; length of stay; major clinical study; male; medical device complication; medical record review; minimally invasive procedure; operation duration; Oswestry Disability Index; paralysis; posterior lumbar interbody fusion; postoperative hemorrhage; retrospective study; spinal hematoma; spine radiography; spondylolisthesis; transient paralysis; visual analog scale; adverse event; clinical competence; education; endoscopy; lumbar vertebra; middle aged; postoperative complication; procedures; spine fusion; surgery; treatment outcome | English | 2020 | 2020-12-18 | 10.1155/2020/8815432 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Translation and Validation of the Korean Version of the Postoperative Quality of Recovery Score QoR-15 | Quality of recovery after anesthesia is an important measure of the early postoperative health status of patients. The Quality of Recovery-15 (QoR-15) questionnaire is a self-rated questionnaire used to assess the quality of postoperative recovery. This study is aimed at translating and validating the Korean version of QoR-15 (QoR-15K). One hundred fifty patients were included in this study. We translated the original version of QoR-15 into QoR-15K and evaluated its validity, reliability, responsiveness, and clinical feasibility. QoR-15K showed acceptable criterion, structure, and construct validities. Reliability was verified using Cronbach's alpha (0.856), standard error of measurement (10.78), split-half reliability (0.831), test-retest reliability (rho=0.945, P <= 0.001), and intraclass correlation test-retest (rho=0.903, P <= 0.001). These results represent an acceptable reliability. Responsiveness was verified using Cohen's effect size (1.39), standardized response mean (1.03), and the correlation between QoR-15K score and duration of anesthesia (rho=-0.197, P=0.016). These results show acceptable responsiveness. The mean +/- standard deviation time to complete QoR-15K was 138.1 +/- 30.7 s. QoR-15K was rated more than adequate on the COnsensus-based Standards for the selection of health Measurement INstruments checklist. In conclusion, QoR-15K shows acceptable validity, reliability, responsiveness, and clinical feasibility and may help evaluate postoperative quality of recovery in Korean populations. | Kim, Donggyeong; Kim, Jay Kyoung; Yeo, Jinseok | Armed Forces Daegu Hosp, Dept Anesthesiol & Pain Med, Gyeongsangbuk Do, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Anesthesiol & Pain Med, Daegu, South Korea | 57230601300; 57218347150; 35072322000 | foavor87@naver.com;kjkng@korea.ac.kr;jsyeo@knu.ac.kr; | BIOMED RESEARCH INTERNATIONAL | BIOMED RES INT | 2314-6133 | 2314-6141 | 2020 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2020 | 3.411 | 43.7 | 0.59 | 2025-06-25 | 13 | 14 | Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesia Recovery Period; Female; Health Status; Humans; Male; Middle Aged; Postoperative Care; Prospective Studies; Quality of Life; Reproducibility of Results; Republic of Korea; Surveys and Questionnaires; adult; anesthesia; article; checklist; consensus; construct validity; controlled study; effect size; feasibility study; female; human; Korean (people); language; major clinical study; male; remission; test retest reliability; aged; anesthetic recovery; health status; middle aged; postoperative care; prospective study; quality of life; questionnaire; reproducibility; South Korea; very elderly | English | 2020 | 2020-10-14 | 10.1155/2020/3456234 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Peroxiredoxin 4 attenuates glutamate-induced neuronal cell death through inhibition of endoplasmic reticulum stress | High concentrations of glutamate induce neurotoxicity by eliciting reactive oxygen species (ROS) generation and intracellular Ca2+ influx. The disruption of Ca2+ homeostasis in the endoplasmic reticulum (ER) evokes ER stress, ultimately resulting in neuronal dysfunction. Additionally, glutamate participates in the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Peroxiredoxins (Prxs) are members of a family of antioxidant enzymes that protect cells from neurotoxic factor-induced apoptosis by scavenging hydrogen peroxide (H2O2). Prx4 is located in the ER and controls the redox condition within the ER. The present study investigated the protective effects of Prx4 against glutamate-induced neurotoxicity linked to ER stress. HT22 cells in which Prx4 was either overexpressed or silenced were used to elucidate the protective role of Prx4 against glutamate toxicity. The expression of Prx4 in HT22 cells was significantly increased in response to glutamate treatment, while ROS scavengers and ER chemical chaperones reduced Prx4 levels. Moreover, Prx4 overexpression reduces glutamate-induced apoptosis of HT22 cells by inhibiting ROS formation, Ca2+ influx, and ER stress. Therefore, we conclude that Prx4 has protective effects against glutamate-induced HT22 cell damage. Collectively, these results suggest that Prx4 could contribute to the treatment of neuronal disorders. | Kang, Ji Hye; Kim, Mi Hye; Lee, Hong Jun; Huh, Jae-Won; Lee, Hyun-Shik; Lee, Dong-Seok | Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu, South Korea; Chungbuk Natl Univ, Coll Med, Chungbuk, South Korea; E Biogen Inc, Res Inst, Seoul, South Korea; KRIBB, Natl Primate Res Ctr, Cheongju, South Korea | Kang, Ji-Hye/D-1945-2013; lee, wj/JNR-4926-2023 | 57216691958; 57193994930; 35215736300; 16645802900; 16316010200; 57210068061 | lee1@knu.ac.kr; | FREE RADICAL RESEARCH | FREE RADICAL RES | 1071-5762 | 1029-2470 | 54 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2020 | 4.148 | 43.9 | 1.02 | 2025-06-25 | 21 | 20 | Glutamate; peroxiredoxin 4; ER stress; ROS; HT22 cells | UNFOLDED PROTEIN RESPONSE; INDUCED OXIDATIVE STRESS; ER STRESS; CALCIUM INFLUX; IRE1; PEROXIDASE; MECHANISMS; APOPTOSIS; PATHWAYS; INJURY | ER stress; Glutamate; HT22 cells; peroxiredoxin 4; ROS | Animals; Apoptosis; Calcium; Cell Line; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Glutamic Acid; Hippocampus; Mice; Neurons; Peroxiredoxins; Reactive Oxygen Species; calcium ion; glutamic acid; peroxiredoxin 4; reactive oxygen metabolite; calcium; glutamic acid; peroxiredoxin; Prdx4 protein, mouse; animal cell; Article; calcium transport; controlled study; endoplasmic reticulum stress; gene overexpression; gene silencing; HT22 cell line; mouse; nerve cell lesion; nerve cell necrosis; neuroapoptosis; neuroprotection; neurotoxicity; nonhuman; protein expression level; animal; apoptosis; biosynthesis; cell line; cytology; drug effect; endoplasmic reticulum; endoplasmic reticulum stress; hippocampus; metabolism; nerve cell | English | 2020 | 2020-04-02 | 10.1080/10715762.2020.1745201 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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