연구성과로 돌아가기
2021 연구성과 (149 / 281)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Characterization of dwarf and narrow leaf (dnl-4) mutant in rice | Height and leaf morphology are important agronomic traits of the major crop plant rice (Oryza sativa). In previous studies, the dwarf and narrow leaf genes (dnl1, dnl2 and dnl3) have identified in rice. Using the Ac/Ds knockout system, we found a new dwarf and narrow leaf (dnl) mutant and identified mutated gene. The dnl-4 mutant showed reduced plant height and leaf blade width compared to the wild type, and increased leaf inclination. The morphological defects of the mutant were caused by the suppressed expression of the DNL-4 gene, which encodes a pfkB carbohydrate kinase protein. These results suggest that DNL-4 expression is involved in modulating plant height and leaf growth. Furthermore, DNL-4 expression also affects productivity in rice: the dnl-4 mutant exhibited reduced panicle length and grain width compared with the wild type. To understand DNL-4 function in rice, we analyzed the expression levels of leaf growth-related genes, such as NAL1, NAL7, and CSLD4, in the dnl-4 mutant. Expression of NAL1 and NAL7 was downregulated in the dnl-4 mutant compared to the wild type. The observation that DNL-4 expression corresponded with that of NAL1 and NAL7 is consistent with the narrow leaf phenotype of the dnl-4 mutant. These results suggest that DNL-4 regulates plant height and leaf structure in rice. | Bae, Ki-Deuk; Um, Tae-Young; Yang, Won-Tae; Park, Tae-Hyeon; Hong, So-Yeon; Kim, Kyung-Min; Chung, Young-Soo; Yun, Dae-Jin; Kim, Doh-Hoon | Dong A Univ, Coll Life Sci & Nat Resources, Busan 49315, South Korea; Kangwon Natl Univ, Dept Agr & Life Ind, Chunchon, South Korea; Seoul Natl Univ, Grad Sch Int Agr Technol, Pyeongchang, South Korea; Seoul Natl Univ, Crop Biotechnol Inst GreenBio Sci & Technol, Pyeongchang, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Daegu, South Korea; Konkuk Univ, Dept Biomed Sci & Engn, Seoul, South Korea | ; Kim, Kyung-Min Kim/C-7007-2014 | 57201327800; 56754885900; 56150341400; 59105265800; 57201310784; 34868260300; 26434587100; 35228284000; 7409766359 | dhkim@dau.ac.kr; | PLANT SIGNALING & BEHAVIOR | PLANT SIGNAL BEHAV | 1559-2316 | 1559-2324 | 16 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;PLANT SCIENCES | 2021 | 2.734 | 40.0 | 1.47 | 2025-07-30 | 18 | 19 | Dwarf and narrow leaf mutant; Oryza sativa; pfkB carbohydrate kinase protein | Dwarf and narrow leaf mutant; Oryza sativa; pfkB carbohydrate kinase protein | Gene Expression Regulation, Plant; Oryza; Plant Leaves; Plant Proteins; plant protein; gene expression regulation; genetics; metabolism; Oryza; physiology; plant leaf | English | 2021 | 2021-02-01 | 10.1080/15592324.2020.1849490 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Mutation of the OsGlyRS3 gene affects heading date in rice | Aminoacyl-tRNA synthetases play a critical role in protein synthesis by catalyzing the covalent attachment of amino acids to their cognate tRNAs. However, the role of aminoacyl-tRNA synthetases in the transition from vegetative to reproductive growth in plants remains poorly understood. In this study, a rice (Oryza sativa) glycyl-tRNA synthetase 3, OsGlyRS3, was found to impact heading date in rice. Flowering in osglyrs3, a mutant line containing a T-DNA insertion in OsGlyRS3, was advanced by approximately 2 weeks compared to wild type. Expression analysis of flowering regulator genes showed that transcript levels of Heading date 1 (Hd1), Heading date 3a (Hd3a), and OsMADS51 were elevated in osglyrs3. These data indicate that the loss of OsGlyRS3 activity induces the expression of flowering-activating genes, resulting in early flowering. | Kim, Yeon Jeong; Kwak, Jun Soo; Dae Hwan, Kwon; Song, Jong Tae; Seo, Hak Soo | Seoul Natl Univ, Dept Agr Forestry & Bioresources, Res Inst Agr & Life Sci, Seoul, South Korea; Seoul Natl Univ, Plant Genom & Breeding Inst, Seoul, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Seoul Natl Univ, BioMAX Inst, Seoul, South Korea | 57202818506; 57188934445; 57223190858; 57797134000; 26642769200 | seohs@snu.ac.kr; | PLANT SIGNALING & BEHAVIOR | PLANT SIGNAL BEHAV | 1559-2316 | 1559-2324 | 16 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;PLANT SCIENCES | 2021 | 2.734 | 40.0 | 0 | 2025-07-30 | 0 | 0 | OsGlyRS3; rice; flowering; glycyl-tRNA synthetase; Hd3a | flowering; glycyl-tRNA synthetase; Hd3a; OsGlyRS3; rice | Flowers; Gene Expression Regulation, Plant; Genes, Plant; Glycine-tRNA Ligase; Mutation; Oryza; Plant Development; Plant Proteins; glycine transfer RNA ligase; plant protein; enzymology; flower; gene expression regulation; genetics; growth, development and aging; mutation; Oryza; physiology; plant development; plant gene | English | 2021 | 2021-07-03 | 10.1080/15592324.2021.1913366 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Clinical significance of vitamin D in idiopathic normal pressure hydrocephalus | Background Although recent studies show vitamin D deficiency is associated with cognitive decline, urinary incontinence, and gait instability, there has been no study on the effect of vitamin D on idiopathic normal pressure hydrocephalus (iNPH) characterized by the classic symptom triad of cognitive decline, urinary incontinence, and gait instability. We investigated the clinical significance of vitamin D in patients with iNPH. Methods Between 2017 and 2020, 44 patients who underwent ventriculoperitoneal shunt surgery were divided into low (= 15 ng/mL) vitamin D groups according to the concentration of 25(OH)D, an effective indicator of vitamin D status. They were respectively evaluated according to clinical and radiological findings. Results The low vitamin D group (n = 24) showed lower preoperative cognition compared to the high vitamin D group (n = 20) in terms of Korean-Mini Mental Status Examination (K-MMSE) and iNPH grading scale (iNPHGS) (K-MMSE: 20.5 +/- 5.4 versus 24.0 +/- 4.5, p = 0.041; iNPHGS cognitive score: 2 +/- 0.9 versus 1 +/- 0.6, p = 0.025). And the low vitamin D group showed pre- and postoperatively more severe urinary incontinence (preoperative iNPHGS urinary score: 1 +/- 1.0 versus 0 +/- 0.9, p = 0.012; postoperative iNPHGS urinary score:1 +/- 1.0 versus 0 +/- 0.9, p = 0.014). The score of narrow high-convexity sulci for the low vitamin D group was lower (low vitamin D group: 1 +/- 0.7 versus high vitamin D group: 2 +/- 0.4, p = 0.031). Conclusion Lower concentration of vitamin D in iNPH may be related to lower preoperative cognition, pre- and postoperative urinary incontinence, and brain morphological change. | Lee, Chaejin; Seo, Hyunwoo; Yoon, Sang-Youl; Chang, Sung Hyun; Park, Seong-Hyun; Hwang, Jeong-Hyun; Kang, Kyunghun; Kim, Chi-Hun; Hahm, Myong Hun; Park, Eunhee; Ahn, Jae Yun; Park, Ki-Su | Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Dept Phys & Rehabil Med, Med Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Daegu, South Korea | ; Ahn, Jae Yun/N-2652-2017 | 57211989339; 57223050421; 57195615457; 57753019200; 21734563200; 7403896906; 55365592200; 56984274000; 56015548700; 56107216400; 56937505400; 55932363100 | kiss798@gmail.com; | ACTA NEUROCHIRURGICA | ACTA NEUROCHIR | 0001-6268 | 0942-0940 | 163 | 7 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2021 | 2.816 | 40.1 | 0.26 | 2025-07-30 | 0 | 3 | Normal pressure hydrocephalus; Vitamin D; Cognition; Urinary incontinence | TAP TEST; SHUNT EFFECTIVENESS; NATIONAL-HEALTH; OLDER-ADULTS; D DEFICIENCY; SYMPTOMS; RECEPTOR | Cognition; Normal pressure hydrocephalus; Urinary incontinence; Vitamin D | Brain; Cognition; Humans; Hydrocephalus, Normal Pressure; Ventriculoperitoneal Shunt; Vitamin D; 25 hydroxyvitamin D; calcium; parathyroid hormone; vitamin D; aged; Article; bone mineralization; brain ventricle peritoneum shunt; calcium blood level; cerebrospinal fluid examination; cerebrospinal fluid tap test; clinical article; cognition assessment; cognitive defect; computer assisted tomography; controlled study; electrochemiluminescence immunoassay; electronic medical record; female; functional assessment; gait disorder; human; male; measurement; neuroimaging; normotensive hydrocephalus; nuclear magnetic resonance imaging; parathyroid hormone blood level; postural headache; preoperative evaluation; radioimmunoassay; urine incontinence; vitamin blood level; vitamin D deficiency; vitamin supplementation; brain; cognition | English | 2021 | 2021-07 | 10.1007/s00701-021-04849-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Usefulness of combination usage of balloon guide catheter with contact aspiration thrombectomy | Background Angiographic outcomes of contact aspiration thrombectomy (CAT), a frontline thrombectomy strategy, can vary depending on balloon guide catheter (BGC) usage, stroke etiology, and occlusion location. The purpose of this study was to analyze conditional outcomes of CAT to determine which result in maximum angiographic benefits. Methods Patients who received CAT for anterior circulation occlusive stroke between January 2017 and December 2018 were included. Angiographic and clinical outcomes were compared relative to BGC use, stroke etiology, and occlusion location. Multivariable analyses for first-pass reperfusion (FPR) and favorable clinical outcome were performed. Results Of 160 included patients, the rates of FPR, successful reperfusion after CAT, final successful reperfusion, and favorable clinical outcome were 43.1%, 58.1%, 81.9%, and 60.6%, respectively. BGC use was associated with a higher rate of FPR, successful reperfusion after CAT, a lower rate of distal embolization, and faster reperfusion. Based on subgroup analysis, BGC usage in ICA, MCA M1 occlusion, and cardioembolism were associated with higher FPR, successful reperfusion after CAT, and lower distal embolization. Faster reperfusion was achieved in ICA occlusions and cardioembolisms. BGC usage was an independent predictor of FPR. Favorable clinical outcome was associated with male gender, low initial NIHSS score, fast onset to reperfusion, and FPR. Conclusions In CAT, BGC usage was associated with better angiographic outcomes, including higher FPR, successful reperfusion after CAT, prevention of distal embolization, and faster reperfusion, especially in proximal occlusions and cardioembolisms. These conditions may play a role in maximizing the benefits of CAT. | Kim, Yong-Won; Kang, Dong-Hun; Son, Wonsoo; Hwang, Yang-Ha; Kim, Yong-Sun; Shin, Jong Wook; Lim, Jeong-Wook; Koh, Hyeon-Song; Kwon, Hyon-Jo | Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Chungnam Natl Univ, Med Sch & Hosp, Daejeon Chungnam Reg Cerebrovasc Ctr, Dept Neurol, Daejeon, South Korea; Chungnam Natl Univ, Med Sch & Hosp, Daejeon Chungnam Reg Cerebrovasc Ctr, Dept Neurosurg, 282 Munhwa Ro, Daejeon 35015, South Korea | HWANG, Yang-Ha/F-3068-2013 | 56203298200; 8977805800; 36676729400; 7402311308; 57095278300; 55649107200; 55929869600; 56273962100; 26647558700 | solesoul@hanmail.net; | ACTA NEUROCHIRURGICA | ACTA NEUROCHIR | 0001-6268 | 0942-0940 | 163 | 6 | SCIE | CLINICAL NEUROLOGY;SURGERY | 2021 | 2.816 | 40.1 | 0.78 | 2025-07-30 | 7 | 6 | Acute ischemic stroke; Contact aspiration thrombectomy; Balloon guide catheter; Stroke etiology; Occlusion location | ACUTE ISCHEMIC-STROKE; LARGE VESSEL OCCLUSION; STENT-RETRIEVER THROMBECTOMY; MECHANICAL THROMBECTOMY; ENDOVASCULAR TREATMENT; REVASCULARIZATION; MULTICENTER; OUTCOMES; THERAPY; TRIAL | Acute ischemic stroke; Balloon guide catheter; Contact aspiration thrombectomy; Occlusion location; Stroke etiology | Aged; Aged, 80 and over; Angiography; Catheters; Endovascular Procedures; Female; Humans; Male; Middle Aged; Multivariate Analysis; Reperfusion; Stroke; Thrombectomy; Treatment Outcome; adult; aged; artery embolism; artery occlusion; Article; artificial embolization; brain hemorrhage; brain ischemia; cardioembolism; cerebrovascular accident; circulation; clinical assessment; clinical outcome; comparative study; contact aspiration thrombectomy; controlled study; coronary angiography; coronary reperfusion; dyslipidemia; female; first pass reperfusion; human; major clinical study; male; mechanical thrombectomy; National Institutes of Health Stroke Scale; occlusive cerebrovascular disease; outcome assessment; priority journal; prospective study; thrombus aspiration; angiography; catheter; cerebrovascular accident; diagnostic imaging; endovascular surgery; middle aged; multivariate analysis; reperfusion; thrombectomy; treatment outcome; very elderly | English | 2021 | 2021-06 | 10.1007/s00701-021-04787-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Application of asymmetric Henry reaction by copper(II) complexes containing (R,R)-1,2-diaminocyclohexane with naphthyl and thiophenyl substituents | A series of Cu(II) complexes containing C-1-symmetric thiophene derivatives of (1R,2R)-N1-(naphthalen-2-ylmethyl)cyclohexane-1,2-diamine, namely L-1, L-2 and L-3 were synthesized and characterized. These complexes had distorted square-planar geometries around the Cu(II) center. High yield (99%) and excellent enantioselectivity (>99%) for (S)-1-nitro-4-phenylbutan-2-ol from the reaction of 3-phenylpropanal and nitromethane was obtained using [(LCu)-Cu-1(OAc)(2)] or [(LCu)-Cu-3(OAc)(2)] with 10 mol% of diisopropylethylamine (DIPEA) within 24 h. The catalytic systems also demonstrated good activity and moderate to high enantioselectivity for aliphatic aldehydes. | Cho, Juhyun; Jeong, Jong Hwa; Lee, Hyosun; Lee, Jungkyu K.; Nayab, Saira | Kyungpook Natl Univ, Dept Chem, 80 Daehakro, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, 80 Daehakro, Daegu 41566, South Korea; Shaheed Benazir Bhutto Univ, Dept Chem, Sheringal Dir U, Khyber Pakhtunk, Pakistan | ; Nayab, Saira/JBS-3013-2023 | 57198450723; 7402045988; 15750846000; 8312040000; 36490286400 | jeongjh@knu.ac.kr;hyosunlee@knu.ac.kr; | INORGANICA CHIMICA ACTA | INORG CHIM ACTA | 0020-1693 | 1873-3255 | 525 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR | 2021 | 3.118 | 40.2 | 0.17 | 2025-07-30 | 2 | 2 | Unsymmetrical chiral diamine ligands; Copper(II) complexes; Asymmetric Henry reaction; beta-Nitroalcohols | X-RAY STRUCTURES; NITROALDOL REACTION; CHIRAL LIGANDS; ALDEHYDES; CU(II); POLYMERIZATION; NITROALKANES; DERIVATIVES; CATALYSTS; SALALEN | Asymmetric Henry reaction; Copper(II) complexes; Unsymmetrical chiral diamine ligands; β-Nitroalcohols | Copper compounds; Enantioselectivity; Synthesis (chemical); Asymmetric Henry reactions; Copper(II) complex; Higher yield; Square planar geometry; Symmetrics; Synthesised; Thiophene derivatives; Thiophenyl; Unsymmetrical chiral diamine ligand; Β-nitroalcohol; Amines | English | 2021 | 2021-09-24 | 10.1016/j.ica.2021.120492 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Autophagy activity contributes to the impairment of social recognition in Epac2⁻/⁻ mice | Autophagy is a lysosomal degradation pathway that regulates cellular homeostasis. It is constitutively active in neurons and controls the essential steps of neuronal development, leading to its dysfunction in neurodevelopmental disorders. Although mTOR-associated impaired autophagy has previously been reported in neurodevelopmental disorders, there is lack of information about the dysregulation of mTOR-independent autophagy in neurodevelopmental disorders. In this study, we investigated whether the loss of Epac2, involved in the mTOR-independent pathway, affects autophagy activity and whether the activity of autophagy is associated with social-behavioral phenotypes in mice with Epac2 deficiencies. We observed an accumulation of autophagosomes and a significant increase in autophagic flux in Epac2-deficient neurons, which had no effect on mTOR activity. Next, we examined whether an increase in autophagic activity contributed to the social behavior exhibited in Epac2(-/-) mice. The social recognition deficit observed in Epac2(-/-) mice recovered in double transgenic Epac2(-/-): Atg5(+/-) mice. Our study suggests that excessive autophagy due to Epac2 deficiencies may contribute to social recognition defects through an mTOR-independent pathway. | Kwak, Ji-Hye; Lee, You-kyung; Jun, Mi-Hee; Roh, Mootaek; Seo, Hyunhyo; Lee, Juhyun; Lee, Kyungmin; Lee, Jin-A | Kyungpook Natl Univ, Sch Med, Behav Neural Circuitry & Physiol Lab, Dept Anat,Brain Sci & Engn Inst, Daegu 41944, South Korea; Hannam Univ, Coll Life Sci & Nanotechnol, Dept Biol Sci & Biotechnol, Daejeon, South Korea | SEO, Hyunhyo/AAR-6343-2021 | 56689173300; 56651292200; 55206261300; 55352054500; 56611228800; 57219315346; 57211016316; 35337365000 | irislkm@knu.ac.kr;jlmaranatha@gmail.com; | MOLECULAR BRAIN | MOL BRAIN | 1756-6606 | 14 | 1 | SCIE | NEUROSCIENCES | 2021 | 4.399 | 40.2 | 0.14 | 2025-07-30 | 3 | 3 | Autophagy; Epac2; Social recognition; Neurodevelopmental disorders | CAMP; DISEASE; GENES | Autophagy; Epac2; Neurodevelopmental disorders; Social recognition | Animals; Autophagy; Behavior, Animal; Guanine Nucleotide Exchange Factors; Mice; Signal Transduction; Social Behavior; TOR Serine-Threonine Kinases; guanine nucleotide exchange factor; Rapgef4 protein, mouse; target of rapamycin kinase; animal; animal behavior; autophagy; metabolism; mouse; signal transduction; social behavior | English | 2021 | 2021-06-28 | 10.1186/s13041-021-00814-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Correction | Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors (vol 8, 7, 2015) | Park, Hyungju; Han, Kyung-Seok; Seo, Jinsoo; Lee, Jaekwang; Dravid, Shashank M.; Woo, Junsung; Chun, Heejung; Cho, Sukhee; Bae, Jin Young; An, Heeyoung; Koh, Woohyun; Yoon, Bo-Eun; Berlinguer-Palmini, Rolando; Mannaioni, Guido; Traynelis, Stephen F.; Bae, Yong Chul; Choi, Se-Young; Lee, C. Justin | Korea Inst Sci & Technol KIST, Ctr Neural Sci, Seoul, South Korea; Univ Sci & Technol UST, Neurosci Program, Daejeon, South Korea; Seoul Natl Univ, Sch Dent, Dept Physiol, Seoul, South Korea; Seoul Natl Univ, Sch Dent, Dent Res Inst, Seoul, South Korea; Creighton Univ, Dept Pharmacol, Omaha, NE 68178 USA; Kyungpook Natl Univ, Sch Dent, Dept Oral Anat & Neurobiol, Daegu, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, 145 Anam Ro, Seoul 02841, South Korea; Dankook Univ, Dept Nanobiomed Sci, Cheonan, South Korea; Newcastle Univ, Inst Neurosci, Sch Elect & Elect Engn, Newcastle Upon Tyne, Tyne & Wear, England; Univ Florence, Dept Pharmacol, Florence, Italy; Emory Univ, Dept Pharmacol, Atlanta, GA 30322 USA | Seo, Jinsoo/AAD-4950-2019; Lee, Jongmin/Q-4909-2019; Palmini, Rolando/K-8764-2013; mannaioni, guido/J-7067-2018; Chun, Heejung/B-3454-2014; Lee, C./AAC-1663-2019 | 36014358600; 55460583400; 7401783716; 57206732862; 7801627483; 54398095600; 56222708600; 55801815000; 55268279500; 56537645200; 57200079653; 36503095500; 6506886997; 6602729707; 7004038241; 56377838800; 7408122846; 7410148866 | sychoi@snu.ac.kr;cjl@kist.re.kr; | MOLECULAR BRAIN | MOL BRAIN | 1756-6606 | 14 | 1 | SCIE | NEUROSCIENCES | 2021 | 4.399 | 40.2 | 1.21 | 2025-07-30 | 0 | 1 | erratum | English | 2021 | 2021-06-29 | 10.1186/s13041-021-00811-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency | CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive gliosis of astrocytes and microglia followed by age-dependent cell death in the excitatory neurons of CTCF cKO mice. To assess the cognitive ability in CTCF cKO mice of over 20 weeks of age, we examined pairwise discrimination (PD), PD reversal learning (PDr), and different paired-associate learning (dPAL) tasks using a touch screen apparatus. We found cognitive impairment in dPAL touch screen tests, suggesting that prolonged Ctcf gene deficiency results in cognitive deficits. | Choi, Dong Il; Kim, Myeongwon; Kim, Somi; Yu, Nam-Kyung; Kwak, Chuljung; Seo, Hyunhyo; Lee, Kyungmin; Kaang, Bong-Kiun | Seoul Natl Univ, Coll Nat Sci, Sch Biol Sci, 1 Gwanangno, Seoul 08826, South Korea; Kyungpook Natl Univ, Sch Med, Dept Anat Brain Sci & Engn Inst, Lab Behav Neural Circuitry & Physiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea | SEO, Hyunhyo/AAR-6343-2021; Kim, SOOCHI/AAD-6959-2020 | 57201740255; 57190806002; 57200557270; 23767421000; 26435938700; 56611228800; 57211016316; 7003889686 | irislkm@knu.ac.kr;kaang@snu.ac.kr; | MOLECULAR BRAIN | MOL BRAIN | 1756-6606 | 14 | 1 | SCIE | NEUROSCIENCES | 2021 | 4.399 | 40.2 | 0.7 | 2025-07-30 | 8 | 10 | ANTERIOR CINGULATE CORTEX; LEARNING PAL TASK; MEMORY; MICE | Animals; Behavior, Animal; CCCTC-Binding Factor; Cognition Disorders; Mice, Knockout; Neurons; Phenotype; transcription factor CTCF; Ctcf protein, mouse; transcription factor CTCF; Article; astrocyte; cell death; cognitive defect; Ctcf gene; gene expression; gene knockout; genotype; gliosis; hippocampal CA1 region; hippocampal CA3 region; human; microglia; nerve excitability; nonhuman; paired associate learning; phenotype; priority journal; protein expression; reversal learning; animal; animal behavior; cognitive defect; knockout mouse; metabolism; nerve cell | English | 2021 | 2021-01-05 | 10.1186/s13041-020-00716-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Generalized Ricci recurrent spacetimes and GRW spacetimes | The main goal of this paper is to study the properties of generalized Ricci recurrent perfect fluid spacetimes and the generalized Ricci recurrent (generalized Robertson-Walker (GRW)) spacetimes. It is proven that if the generalized Ricci recurrent perfect fluid spacetimes satisfy the Einstein's field equations without cosmological constant, then the isotropic pressure and the energy density of the perfect fluid spacetime are invariant along the velocity vector field of the perfect fluid spacetime. In this series, we show that a generalized Ricci recurrent perfect fluid spacetime satisfying the Einstein's field equations without cosmological constant is either Ricci recurrent or Ricci symmetric. An n-dimensional compact generalized Ricci recurrent GRW spacetime with almost Ricci soliton is geodesically complete, provided the soliton vector field of almost Ricci soliton is timelike. Also, we prove that a (GR)(n) GRW spacetime is Einstein. The properties of (GR)(n) GRW spacetimes equipped with almost Ricci soliton are studied. | Chaubey, Sudhakar K.; Suh, Young Jin | Univ Technol & Appl Sci Shinas, Dept Informat Thchnol, Sect Math, POB 77, Sohar 324, Oman; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, RIRCM, Daegu 41566, South Korea | Chaubey, S./ABB-6952-2021 | 36117508600; 7202260479 | sudhakar.chaubey@shct.edu.om;yjsuh@knu.ac.kr; | INTERNATIONAL JOURNAL OF GEOMETRIC METHODS IN MODERN PHYSICS | INT J GEOM METHODS M | 0219-8878 | 1793-6977 | 18 | 13 | SCIE | PHYSICS, MATHEMATICAL | 2021 | 1.873 | 40.2 | 1.3 | 2025-07-30 | 14 | 13 | Generalized Robertson-Walker spacetimes; perfect fluid spacetimes; generalized Ricci recurrent manifolds; Einstein spacetimes; almost Ricci solitons | ROBERTSON-WALKER SPACETIMES; PERFECT FLUID SPACETIMES; LORENTZ MANIFOLDS; CURVATURE; HYPERSURFACES; COMPLETENESS; SOLITONS; GEOMETRY | almost Ricci solitons; Einstein spacetimes; generalized Ricci recurrent manifolds; Generalized Robertson-Walker spacetimes; perfect fluid spacetimes | English | 2021 | 2021-11 | 10.1142/s0219887821502091 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Histone deacetylase inhibitor, mocetinostat, regulates cardiac remodelling and renin-angiotensin system activity in rats with transverse aortic constriction-induced pressure overload cardiac hypertrophy | Histone deacetylase (HDAC) inhibitors have shown cardioprotective or renoprotective effects in various animal models. Our study proposed that the HDAC inhibitor, mocetinostat, regulates cardiac remodelling and renin-angiotensin system (RAS) activity in rats with transverse aortic constriction (TAC)-induced pressure overload cardiac hypertrophy. Cardiac remodelling was evaluated using echocardiography. Cardiac hypertrophy was visualized with haematoxylin and eosin staining, and related gene (Nppa and Nppb) expression was quantified by quantitative real-time polymerase chain reaction (qRT-PCR). Cardiac and renal fibrosis were visualized with picrosirius red and trichrome staining, respectively. Fibrosis related gene (Collagen-1, Collagen-3, Ctgf, and Fibronectin) expression was determined by qRT-PCR. Serum concentrations of RAS components (renin, angiotensin II, and aldosterone) were quantified by enzyme-linked immunosorbent assay and related gene (Renin and Agtr1) expression was determined by qRT-PCR. TAC-induced pressure overload cardiac hypertrophy, which mimics hypertensive heart disease, increased cardiac remodelling, cardiac hypertrophy, and fibrosis in our rat models. Upon treatment with mocetinostat, there was a significant regression in cardiac remodelling, cardiac hypertrophy, and fibrosis in TAC rats. Additionally, pressure overload-induced renal fibrosis and activity of RAS-related components were increased in TAC rats, and were decreased on treatment with mocetinostat. The present study indicates that mocetinostat, an HDAC inhibitor, has cardiorenal protective effects in rats with TAC-induced pressure overload cardiac hypertrophy and offers a promising therapeutic agent for hypertension-related diseases. | Kim, Gun Jik; Jung, Hanna; Lee, Eunjo; Chung, Sung Woon | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Thorac & Cardiovasc Surg, Daegu 41944, South Korea; Minist Food & Drug Safety, Emerging Infect Dis Vaccines Div, Natl Inst Food & Drug Safety Evaluat, Cheongju 28159, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Thorac & Cardiovasc Surg, Sch Med, Busan 49241, South Korea | ; Jung, Hanna/Y-4165-2019 | 22234444300; 56467570700; 57190980166; 55153017300 | sungwoon@pusan.ac.kr; | REVIEWS IN CARDIOVASCULAR MEDICINE | REV CARDIOVASC MED | 1530-6550 | 2153-8174 | 22 | 3 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2021 | 4.43 | 40.2 | 0.58 | 2025-07-30 | 7 | 8 | Animal model; Fibrosis; Heart; Histone deacetylase; Hypertension; Hypertrophy; Kidney | FIBROSIS; HYPERTENSION; DAMAGE | Animal model; Fibrosis; Heart; Histone deacetylase; Hypertension; Hypertrophy; Kidney | Animals; Benzamides; Cardiomegaly; Constriction; Fibrosis; Histone Deacetylase Inhibitors; Humans; Myocardium; Pyrimidines; Rats; Renin-Angiotensin System; Ventricular Remodeling; aldosterone; angiotensin II; collagen type 1; collagen type 3; connective tissue growth factor; fibronectin; mocetinostat; renin; benzamide derivative; histone deacetylase inhibitor; mocetinostat; pyrimidine derivative; Agtr1 gene; aldosterone blood level; angiotensin blood level; animal experiment; animal model; animal tissue; aortic constriction; Article; collagen type 1 gene; collagen type 3 gene; controlled study; Ctgf gene; drug targeting; echocardiography; enzyme linked immunosorbent assay; Fibronectin gene; gene; gene expression; haematoxylin and eosin staining; heart muscle fibrosis; heart protection; heart ventricle hypertrophy; heart ventricle remodeling; hypertension; kidney fibrosis; male; nonhuman; Nppa gene; Nppb gene; picrosirius red staining; plasma renin activity; rat; real time polymerase chain reaction; remission; renal protection; renin angiotensin aldosterone system; Renin gene; staining; trichrome staining; animal; cardiac muscle; cardiomegaly; fibrosis; heart ventricle remodeling; human; ligation; metabolism; pathology; renin angiotensin aldosterone system | English | 2021 | 2021-09-24 | 10.31083/j.rcm2203113 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells | As a dynamic organelle, mitochondria continuously fuse and divide with adjacent mitochondria. Imbalance in mitochondria dynamics leads to their dysfunction, which implicated in neurodegenerative diseases. However, how mitochondria alteration and glucose defect contribute to pathogenesis of Alzheimer's disease (AD) is still largely unknown. Dynamin-related protein 1 (Drp1) is an essential regulator for mitochondria fission. Among various posttranslational modifications, O-GlcNAcylation plays a role as a sensor for nutrient and oxidative stress. In this study, we identified that Drp1 is regulated by O-GlcNAcylation in AD models. Treatment of A beta as well as PugNAc resulted in mitochondrial fragmentation in neuronal cells. Moreover, we found that AD mice brain exhibits an upregulated Drp1 O-GlcNAcylation. However, depletion of OGT inhibited Drp1 O-GlcNAcylation in A beta-treated cells. In addition, overexpression of O-GlcNAc defective Drp1 mutant (T585A and T586A) decreased Drp1 O-GlcNAcylation and A beta-induced mitochondria fragmentation. Taken together, these finding suggest that A beta regulates mitochondrial fission by increasing O-GlcNAcylation of Drp1. | Park, So Jung; Bae, Ji-Eun; Jo, Doo Sin; Kim, Joon Bum; Park, Na Yeon; Fang, Jianguo; Jung, Yong-Keun; Jo, Dong Gyu; Cho, Dong-Hyung | Univ Cambridge, Cambridge Inst Med Res, Dept Med Genet, Cambridge CB2 0XY, England; Kyungpook Natl Univ, Grad Sch Life Sci, Brain Sci & Engn Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Grad Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, 80 Daehakro Bukgu, Daegu 41566, South Korea; Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; Seoul Natl Univ, Sch Biol Sci, Seoul 08826, South Korea; Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea | Kim, Joon/ADP-8066-2022; Jo, Dong-Gyu/AAN-9278-2021; Choi, Hye Rin/JDV-9065-2023; KIM, SUNG/ADF-8559-2022 | 58839092700; 57190605352; 56335489800; 57190611030; 57190609826; 23027231500; 35358575000; 7006823770; 35093684400 | dhcho@knu.ac.kr; | MOLECULAR BRAIN | MOL BRAIN | 1756-6606 | 14 | 1 | SCIE | NEUROSCIENCES | 2021 | 4.399 | 40.2 | 2.04 | 2025-07-30 | 33 | 31 | Drp1; O-GlcNAcylation; Mitochondrial fission; Amyloid-beta; Alzheimer's disease | Alzheimer’s disease; Amyloid-beta; Drp1; Mitochondrial fission; O-GlcNAcylation | Amyloid beta-Peptides; Animals; Cells, Cultured; Dynamins; Glycosylation; Humans; Mice, Transgenic; Mitochondrial Dynamics; Neurons; amyloid beta protein; dynamin related protein 1; mutant protein; regulator protein; unclassified drug; amyloid beta protein; DNM1L protein, human; Dnm1l protein, mouse; dynamin; Alzheimer disease; animal cell; animal experiment; animal model; animal tissue; Article; controlled study; disease model; disorders of mitochondrial functions; gene overexpression; human; human cell; mitochondrion; mouse; mouse model; nerve cell; nonhuman; o linked n acetylglucosaminylation; priority journal; protein modification; regulatory mechanism; SH-SY5Y cell line; upregulation; animal; cell culture; glycosylation; metabolism; mitochondrial dynamics; nerve cell; transgenic mouse | English | 2021 | 2021-01-09 | 10.1186/s13041-020-00727-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | SARS-CoV-2 main protease inhibition by compounds isolated from Luffa cylindrica using molecular docking | In this study, chemical investigation of methanol extract of the air-dried fruits of Luffa cylindrica led to the identification of a new delta-valerolactone (1), along with sixteen known compounds (2-17). Their chemical structures including the absolute configuration were elucidated by extensive spectroscopic analysis and electronic circular dichroism analysis, as well as by comparison with those reported in the literature. For the first time in literature, we have examined the binding potential of the isolated compounds to highly conserved protein, Mpro of SARS-CoV-2 using the molecular docking technique. We found that the isolated saponins (14-17) bind to the substrate-binding pocket of SARS-CoV-2 Mpro with docking energy scores of -7.13, -7.29, -7.47, and -7.54 kcal.mol- 1, respectively, along with binding abilities equivalent to an already claimed N3 protease inhibitor (-7.51 kcal.mol(-1)). | Cao, Thao Quyen; Kim, Jeong Ah; Woo, Mi Hee; Min, Byung Sun | Daegu Catholic Univ, Coll Pharm, Drug Res & Dev Ctr, Gyeongbuk 38430, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Wonkwang Univ, Inst Pharmaceut Res & Dev, Coll Pharm, Iksan 54538, South Korea | Quyen, Cao/AAP-9678-2020 | 56937820500; 24722570900; 7201527720; 55663638200 | bsmin@cu.ac.kr; | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | BIOORG MED CHEM LETT | 0960-894X | 1464-3405 | 40 | SCIE | CHEMISTRY, MEDICINAL;CHEMISTRY, ORGANIC | 2021 | 2.94 | 40.2 | 0.92 | 2025-07-30 | 10 | 11 | Luffa cylindrical; Saponins; Valerolactone; SARS-CoV-2; Molecular docking | TRITERPENOID SAPONINS; ACID; CONSTITUENTS; DERIVATIVES; LEAVES; SKIN | Luffa cylindrical; Molecular docking; Saponins; SARS-CoV-2; Valerolactone | Antiviral Agents; Catalytic Domain; Coronavirus 3C Proteases; Cysteine Proteinase Inhibitors; Fruit; Luffa; Molecular Docking Simulation; Protein Binding; Saponins; SARS-CoV-2; anticoronavirus agent; delta valerolactone; Luffa cylindrica extract; plant extract; saponin derivative; unclassified drug; viral protease; 3C-like proteinase, SARS-CoV-2; antivirus agent; cysteine proteinase inhibitor; protein binding; saponin; antiviral activity; Article; binding site; drug binding; drug identification; drug screening; drug structure; enzyme inhibition; enzyme substrate complex; Luffa aegyptiaca; molecular docking; nonhuman; Severe acute respiratory syndrome coronavirus 2; structure analysis; chemistry; drug effect; enzyme active site; fruit; isolation and purification; Luffa; metabolism | English | 2021 | 2021-05-15 | 10.1016/j.bmcl.2021.127972 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Yamabe and quasi-Yamabe solitons in paracontact metric manifolds | The aim of this paper is to characterize paracontact metric manifolds admitting Yamabe and quasi-Yamabe solitons. Several results of such solitons are proved. In particular, we classify Yamabe and quasi-Yamabe solitons on (k, mu)-paracontact metric manifolds. | De, Uday Chand; Suh, Young Jin | Univ Calcutta, Dept Pure Math, 35 Ballygunge Circular Rd, Kolkata 700019, W Bengal, India; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, RIRCM, Daegu 41566, South Korea | 7007046738; 7202260479 | uc_de@yahoo.com;yjsuh@knu.ac.kr; | INTERNATIONAL JOURNAL OF GEOMETRIC METHODS IN MODERN PHYSICS | INT J GEOM METHODS M | 0219-8878 | 1793-6977 | 18 | 12 | SCIE | PHYSICS, MATHEMATICAL | 2021 | 1.873 | 40.2 | 0.5 | 2025-07-30 | 8 | 9 | Paracontact metric manifolds; Yamabe solitons; quasi-Yamabe solitons; W-Ric vector fields | Paracontact metric manifolds; quasi-Yamabe solitons; W - Ric vector fields; Yamabe solitons | English | 2021 | 2021-10 | 10.1142/s0219887821501966 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Fabrication and Characterization of Graphene Oxide-Coated Plate for Efficient Culture of Stem Cells | BACKGROUND: For stem cell applications in regenerative medicine, it is very important to produce high-quality stem cells in large quantities in a short time period. Recently, many studies have shown big potential of graphene oxide as a biocompatible substance to enhance cell growth. We investigated if graphene oxide-coated culture plate can promote production efficiency of stem cells. METHODS: Three types of graphene oxide were used for this study. They are highly concentrated graphene oxide solution, single-layer graphene oxide solution, and ultra-highly concentrated single-layer graphene oxide solution with different single-layer ratios, and coated on cell culture plates using a spray coating method. Physiochemical and biological properties of graphene oxide-coated surface were analyzed by atomic force microscope (AFM), scanning electron microscope (SEM), cell counting kit, a live/dead assay kit, and confocal imaging. RESULTS: Graphene oxide was evenly coated on cell culture plates with a roughness of 6.4 similar to 38.2 nm, as measured by SEM and AFM. Young's Modulus value was up to 115.1 GPa, confirming that graphene oxide was strongly glued to the surface. The ex vivo stem cell expansion efficiency was enhanced as bone marrow-derived stem cell doubling time on the graphene oxide decreased compared to the control (no graphene oxide coating), from 64 to 58 h, and the growth rate increased up to 145%. We also observed faster attachment and higher affinity of stem cells to the graphene oxide compared to control by confocal microscope. CONCLUSION: This study demonstrated that graphene oxide dramatically enhanced the ex vivo expansion efficiency of stem cells. Spray coating enabled an ultra-thin coating of graphene oxide on cell culture plates. The results supported that utilization of graphene oxide on culture plates can be a promising mean for mass production of stem cells for commercial applications. | Park, Danbi; Park, Jaebum; Lee, Jihoon; Shim, Chang Jae; Kim, Min Sung; Lee, Tae Yong; Lim, Jeong Ok | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Biomed Res Inst,Joint Inst Regenerat Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Convergence & Fus Syst Engn, Sangju Si 37224, South Korea; Corestem Inc, Cent Res Ctr, 255 Pangyo Ro, Seoul 13486, South Korea | 57235629000; 57237034300; 59832369300; 57533870900; 57218438989; 57205775062; 7403454245 | jolim@knu.ac.kr; | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | TISSUE ENG REGEN MED | 1738-2696 | 2212-5469 | 18 | 5 | SCIE | CELL & TISSUE ENGINEERING;ENGINEERING, BIOMEDICAL | 2021 | 4.451 | 40.3 | 0.52 | 2025-07-30 | 7 | 7 | Graphene oxide; Ex vivo expansion efficiency; Stem cell; Large-scale cell culture | CHEMISTRY | Ex vivo expansion efficiency; Graphene oxide; Large-scale cell culture; Stem cell | Cell Proliferation; Graphite; Stem Cells; Atomic force microscopy; Biocompatibility; Bone; Cell culture; Cell proliferation; Efficiency; Protective coatings; Scanning electron microscopy; Stem cells; graphene oxide; graphene oxide; graphite; Biological properties; Cell culture plates; Commercial applications; Confocal imaging; Ex vivo expansion; Fabrication and characterizations; Production efficiency; Stem cell expansion; Article; atomic force microscopy; cell counting; cell culture; cell function; cell proliferation; cell structure; cell viability; comparative study; confocal microscopy; controlled study; ex vivo study; fibroblast; growth rate; hematopoietic stem cell; human; human cell; physical chemistry; production efficiency; scanning electron microscopy; spray coating; stem cell expansion; stem cell; Graphene | English | 2021 | 2021-10 | 10.1007/s13770-021-00370-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | IL-10 Deficiency Aggravates Renal Inflammation, Fibrosis and Functional Failure in High-Fat Dieted Obese Mice | BACKGROUND: High-fat diet-induced obesity is one of the major cause of chronic renal failure. This obesity-related renal failure is mainly caused by inflammatory processes. However, the role of the major anti-inflammatory cytokine interleukin (IL)-10 has not been researched intensively. METHODS: To evaluate the effect of IL-10 deficiency on obesity-related renal failure, the in vivo study was carried with four animal groups; (1) Low-fat dieted C57BL/6 mice, (2) Low-fat dieted IL-10 knockout (KO) mice, (3) High-fat dieted C57BL/6 mice and (4) High-fat dieted IL-10 KO mice group. The analysis was carried with blood/urine chemistry, H&E, Oil-Red-O, periodic acid-Schiff and Masson's trichrome staining immunohistochemistry and real-time PCR methods. RESULTS: At week 12, high-fat dieted IL-10 KO mice showed 1) severe lipid accumulation in kidneys, cholesterol elevation (in total, serum kidney) and low-density lipoprotein increasion through the SCAP-SREBP2-LDLr pathway; (2) serious histopathologic alterations showing glomerulosclerosis, tubulointerstitial fibrosis and immune cell infiltration; (3) increased pro-inflammatory cytokines and chemokines expression; (4) enhanced renal fibrosis; and (5) serious functional failure with high serum creatinine and BUN and proteinuria excretion compared to other groups. CONCLUSION: IL-10 deficiency aggravates renal inflammation, fibrosis and functional failure in high-fat dieted obese mice, thus IL-10 therapy could be applied to obesity-related chronic renal failure. | Kim, Dae Hwan; Chun, So Young; Lee, EunHye; Kim, Bomi; Yoon, BoHyun; Gil, Haejung; Han, Man-Hoon; Ha, Yun-Sok; Lee, Jun Nyung; Kwon, Tae Gyun; Kim, Bum Soo; Jang, Byung Ik | Yeungnam Univ, Dept Lab Anim Res Support Team, Med Ctr, Daegu 42415, South Korea; Kyungpook Natl Univ Hosp, BioMed Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Urol, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Yeungnam Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Kim, Soo-Yeon/ADR-9663-2022; Kim, Jihyun/F-6940-2013 | 55897992900; 8688166900; 57189661699; 57218929773; 57218931150; 57221906264; 57194067936; 35487226400; 16301364600; 15073765400; 57202817150; 22953491400 | dock97@hanmail.net;bijang@yumail.ac.kr; | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | TISSUE ENG REGEN MED | 1738-2696 | 2212-5469 | 18 | 3 | SCIE | CELL & TISSUE ENGINEERING;ENGINEERING, BIOMEDICAL | 2021 | 4.451 | 40.3 | 1.65 | 2025-07-30 | 21 | 23 | IL-10 deficiency; Renal failure; Obesity; High-fat diet | High-fat diet; IL-10 deficiency; Obesity; Renal failure | Animals; Diet, High-Fat; Fibrosis; Inflammation; Interleukin-10; Mice; Mice, Inbred C57BL; Mice, Obese; Chemical analysis; Drug products; Nutrition; Pathology; Polymerase chain reaction; alpha smooth muscle actin; C reactive protein; CD3 antigen; chemokine; cholesterol; collagen type 1; cytokine; fibronectin; glyceraldehyde 3 phosphate dehydrogenase; interleukin 10; interleukin 6; leptin; low density lipoprotein; low density lipoprotein receptor; sterol regulatory element binding protein 2; tumor necrosis factor; interleukin 10; Anti-inflammatories; Chronic renal failure; Immunohistochemistry; Inflammatory cytokines; Inflammatory process; Lipid accumulations; Low density lipoproteins; Real-time PCR method; animal experiment; animal model; animal tissue; Article; blood chemistry; C57BL 6 mouse; cell infiltration; cholesterol blood level; controlled study; cytokine release; disease association; disease severity; glomerulosclerosis; immunocompetent cell; immunohistochemistry; in vivo study; interleukin 10 deficiency; kidney failure; kidney fibrosis; kidney function; knockout mouse; lipid diet; lipid storage; low fat diet; male; Masson trichrome staining; mouse; mouse model; nephritis; nonhuman; obesity; periodic acid Schiff stain; protein blood level; protein deficiency; protein expression; protein function; real time polymerase chain reaction; signal transduction; staining; urea nitrogen blood level; urine chemistry; adverse event; animal; C57BL mouse; fibrosis; genetics; inflammation; mouse mutant; Mammals | English | 2021 | 2021-06 | 10.1007/s13770-020-00328-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: