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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | A Modified eCura System to Stratify the Risk of Lymph Node Metastasis in Undifferentiated-Type Early Gastric Cancer After Endoscopic Resection | Purpose: The original eCura system was designed to stratify the risk of lymph node metastasis (LNM) after endoscopic resection (ER) in patients with early gastric cancer (EGC). We assessed the effectiveness of a modified eCura system for reflecting the characteristics of undifferentiated-type (UD)-EGC. Materials and Methods: Six hundred thirty-four patients who underwent non-curative ER for UD-EGC and received either additional surgery (radical surgery group; n=270) or no further treatment (no additional treatment group; n=364) from 18 institutions between 2005 and 2015 were retrospectively included in this study. The eCuraU system assigned 1 point each for tumors >20 mm in size, ulceration, positive vertical margin, and submucosal invasion m; 2 points for submucosal invasion >= 500 mu m; and 3 points for lymphovascular invasion. Results: LNM rates in the radical surgery group were 1.1%, 5.4%, and 13.3% for the low- (0-1 point), intermediate- (2-3 points), and high-risk (4-8 points), respectively (P-for-trend<0.001). The eCuraU system showed a significantly higher probability of identifying patients with LNM as high-risk than the eCura system (66.7% vs. 22.2%; McNemar P<0.001). In the no additional treatment group, overall survival (93.4%, 87.2%, and 67.6% at 5 years) and cancer-specific survival (99.6%, 98.9%, and 92.9% at 5 years) differed significantly among the low-, intermediate-, and high-risk categories, respectively (both P<0.001). In the high-risk category, surgery outperformed no treatment in terms of overall mortality (hazard ratio, 3.26; P=0.015). Conclusions: The eCuraU system stratified the risk of LNM in patients with UD-EGC after ER. It is strongly recommended that high-risk patients undergo additional surgery. | Yang, Hyo-Joon; Lee, Hyuk; Kim, Tae Jun; Jung, Da Hyun; Choi, Kee Don; Ahn, Ji Yong; Lee, Wan Sik; Jeon, Seong Woo; Kim, Jie-Hyun; Ha Kim, Gwang; Park, Jae Myung; Kim, Sang Gyun; Shin, Woon Geon; Kim, Young-Il; Choi, Il Ju | Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Div Gastroenterol,Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Gastrointestinal Canc Ctr, Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea; Yonsei Univ, Coll Med, Inst Gastroenterol, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Div Gastroenterol, Seoul, South Korea; Chonnam Natl Univ, Med Sch, Dept Internal Med, Gwangju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Internal Med,Inst Gastroenterol, Seoul, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Pusan, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Div Gastroenterol, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Liver Res Inst, Coll Med, Seoul, South Korea; Hallym Univ, Inst Liver & Digest Dis, Coll Med, Dept Internal Med, Chunchon, South Korea; Natl Canc Ctr, Ctr Gastr Canc, Res Inst & Hosp, Goyang, South Korea; Natl Canc Ctr, Res Inst & Hosp, Ctr Gastr Canc, 323 Ilsan Ro, Goyang 10408, South Korea | ; Ahn, Ji Yong/AGO-1695-2022; LEE, KYUNG-HAN/HPD-9299-2023; Jeon, Seongwoo/AAU-4618-2020; Kim, Jie-Hyun/Q-9061-2019; Kim, Gwang Ha/ABF-3932-2021; Kim, Yuriy/ABD-7016-2020 | 57188930761; 57304930200; 57189389501; 57965484700; 14621577200; 36809017800; 57208140974; 9733636500; 49461401400; 35214772400; 8548758100; 56371524600; 13606883400; 57203809495; 7401471464 | cij1224@ncc.re.kr; | JOURNAL OF GASTRIC CANCER | J GASTRIC CANCER | 2093-582X | 2093-5641 | 24 | 2 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2024 | 3.8 | 27.6 | 2.13 | 2025-05-07 | 4 | 4 | Stomach neoplasms; Undifferentiated-type histology; Endoscopic mucosal resection; Lymph node metastasis; Risk assessment | LONG-TERM OUTCOMES; SUBMUCOSAL DISSECTION; CRITERIA; SURGERY; MODEL | Endoscopic mucosal resection; Lymph node metastasis; Risk assessment; Stomach neoplasms; Undifferentiated-type histology | adult; aged; Article; cancer mortality; cancer risk; cancer specific survival; cancer staging; cohort analysis; colloid carcinoma; computer assisted tomography; controlled study; demographics; diagnostic test accuracy study; disease free survival; eCura system; endoscopic mucosal resection; endoscopic surgery; endoscopy; female; follow up; gastrectomy; high risk patient; histology; human; human tissue; immunohistochemistry; low risk patient; lymph node dissection; lymph node metastasis; lymph vessel metastasis; male; mortality; multicenter study; outcome assessment; overall survival; predictive value; retrospective study; risk assessment; risk factor; scoring system; stomach cancer; systematic review (topic); tumor volume; undifferentiated type early gastric cancer | English | 2024 | 2024-04 | 10.5230/jgc.2024.24.e13 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Analysis of microbiological tests in patients withholding or withdrawing life-sustaining treatment at the end stage of life in 2 Korean hospitals | Objective:We evaluated the adequacy of microbiological tests in patients withholding or withdrawing life-sustaining treatment (WLST) at the end stage of life.Setting:The study was conducted at 2 tertiary-care referral hospitals in Daegu, Republic of Korea.Design:Retrospective cross-sectional study.Methods:Demographic findings, clinical and epidemiological characteristics, statistics of microbiological tests, and microbial species isolated from patients within 2 weeks before death were collected in 2 tertiary-care referral hospitals from January to December 2018. We also reviewed the antimicrobial treatment that was given within 3 days of microbiological testing in patients on WLST.Results:Of the 1,187 hospitalized patients included, 905 patients (76.2%) had WLST. The number of tests per 1,000 patient days was higher after WLST than before WLST (242.0 vs 202.4). Among the category of microbiological tests, blood cultures were performed most frequently, and their numbers per 1,000 patient days before and after WLST were 95.9 and 99.0, respectively. The positive rates of blood culture before and after WLST were 17.2% and 18.0%, respectively. Candida spp. were the most common microbiological species in sputum (17.4%) and urine (48.2%), and Acinetobacter spp. were the most common in blood culture (17.3%). After WLST determination, 70.5% of microbiological tests did not lead to a change in antibiotic use.Conclusions:Many unnecessary microbiological tests are being performed in patients with WLST within 2 weeks of death. Microbiological testing should be performed carefully and in accordance with the patient's treatment goals. | Bae, Sohyun; Kwon, Ki Tae; Hwang, Soyoon; Kim, Yoonjung; Chang, Hyun-Ha; Kim, Shin-Woo; Lee, Nan Young; Kim, Yu Kyoung; Lee, Je Chul | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu, South Korea; Kyungpook Natl Univ, Dept Internal Med, Div Infect Dis, Chilgok Hosp, 807 Hokuk Ro, Daegu 41404, South Korea | Kim, Tae-You/J-2750-2012; Hwang, Soyoon/HHM-5762-2022; Kim, Sun/G-3451-2013; Kim, Young-Il/ISS-7678-2023; Kim, Hanjin/KYP-2633-2024 | 57219699506; 9733850500; 57203160675; 57203160508; 7407521688; 57189703358; 57209204358; 9237571900; 25930392000 | ktkwon@knu.ac.kr;sangdo86@naver.com; | INFECTION CONTROL & HOSPITAL EPIDEMIOLOGY | INFECT CONT HOSP EP | 0899-823X | 1559-6834 | 45 | 2 | SCIE | INFECTIOUS DISEASES;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2024 | 2.9 | 27.6 | 0 | 2025-05-07 | 1 | 0 | CULTURES | Clinical Decision-Making; Cross-Sectional Studies; Humans; Retrospective Studies; Tertiary Care Centers; Withholding Treatment; antibiotic agent; carbapenem; glycopeptide; Acinetobacter; aged; antimicrobial therapy; Article; blood culture; Candida; controlled study; cross-sectional study; demographics; female; hospital patient; human; in-hospital mortality; life sustaining treatment; major clinical study; male; microbiological examination; nonhuman; patient referral; positivity rate; retrospective study; South Korea; sputum; sputum analysis; terminal care; tertiary health care; treatment withdrawal; urinalysis; clinical decision making; tertiary care center | English | 2024 | 2024-02 | 10.1017/ice.2023.191 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Association of Soy Foods With Gastric Cancer Considering Helicobacter pylori: A Multi-Center Case-Control Study | Purpose: This study aims to explore the relationship between soy food consumption and gastric cancer (GC) risk, accounting for Helicobacter pylori infection status. Materials and Methods: We analyzed data from patients with GC and healthy individuals prospectively enrolled by 6 hospitals between 2016 and 2018. Dietary intake was evaluated using questionnaires that categorized seven dietary habits and 19 food groups. Multivariate logistic regression models were applied to examine associations. Model I adjusted for various epidemiological factors, while Model II included further adjustments for H. pylori infection. Primary exposures examined were consumption frequencies of nonfermented, unsalted soy foods (soybean/tofu) and fermented, salty soy foods (soybean paste stew). Results: A total of 5,535 participants were included, with 1,629 diagnosed with GC. In Model I, the frequency of soybean/tofu consumption was inversely related to GC risk; adjusted odd ratios (aORs) were 0.62 (95% confidence interval [CI], 0.48-0.8), 0.38 (95% CI, 0.3-0.49), 0.42 (95% CI, 0.33-0.53), and 0.33 (95% CI, 0.27-0.42) for 1 time/week, 2 times/week, 3 times/week, and >= 4 times/week. Consumption of 2 servings/week of soybean paste stew showed the lowest GC association, forming a V-shaped curve. Both low (aOR, 4.03; 95% CI, 3.09-5.26) and high serving frequencies of soybean paste stew (aOR, 2.23; 95% CI, 1.76-2.82) were associated with GC. The association between soy foods and GC in Model II was similar to that in Model I. The soy food-GC associations were consistent across sexes in Model I. Nonetheless, the positive correlation between frequent consumption of soybean paste stew (>= 5 times/week) and GC was more pronounced in women (aOR, 7.58; 95% CI, 3.20-17.99) compared to men (aOR, 3.03; 95% CI, 1.61-5.88) in Model II. Subgroup analyses by H. pylori status and salty diet revealed a consistent inverse relationship between soybean/tofu and GC risk. In contrast, soybean paste stew showed a V-shaped relationship in H. pylori-positive or salty diet groups and no significant association in the H. pylori-negative group. Conclusions: Soybean/tofu intake is consistently associated with a decreased risk of GC. However, the relationship between soybean paste stew consumption and GC risk varies, depending on H. pylori infection status and dietary salt intake. | Nam, Su Youn; Jeon, Seong Woo; Kwon, Joong Goo; Chung, Yun Jin; Kwon, Yong Hwan; Lee, Si Hyung; Lee, Ju Yup; Yang, Chang Hun; Jo, Junwoo | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Gastroenterol, 807 Hoguk Ro, Daegu 41404, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Fatima Hosp, Dept Internal Med, Daegu, South Korea; Yeungnam Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea | ; Lee, Hyun Woo/AAH-8473-2020; Jeon, Seongwoo/AAU-4618-2020; Lee, Si/ABH-1408-2020 | 55617028500; 9733636500; 12779951100; 57199411938; 58950750100; 35771122400; 55891683700; 57207279888; 57210425017 | swjeon@knu.ac.kr; | JOURNAL OF GASTRIC CANCER | J GASTRIC CANCER | 2093-582X | 2093-5641 | 24 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2024 | 3.8 | 27.6 | 0 | 2025-05-07 | 0 | 0 | Gastric cancer; Soy beans; Helicobacterpylori | PROCESSED MEAT CONSUMPTION; STOMACH-CANCER; DIETARY FACTORS; VEGETABLE INTAKE; SALTED FOOD; LIFE-STYLE; RISK; POPULATION; FRUIT; ADENOCARCINOMA | Gastric cancer; Helicobacter pylori; Soy beans | immunoglobulin G; midazolam; propofol; adult; Article; body mass; cancer risk; case control study; cerebrovascular disease; chemiluminescence immunoassay; controlled study; diabetes mellitus; endoscopy; female; food frequency questionnaire; food intake; ginseng; Helicobacter infection; Helicobacter pylori; human; human experiment; hypertension; major clinical study; male; middle aged; multicenter study; multivariate logistic regression analysis; obesity; physical activity; prospective study; questionnaire; soy food; stomach cancer | English | 2024 | 2024-10 | 10.5230/jgc.2024.24.e39 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Comparison of the Prognosis of Upper-Third Gastric Cancer With That of Middle and Lower-Third Gastric Cancer | Purpose: Gastric cancer is one of the most common cancers in Korea, and the proportion of upper-third gastric cancers has been steadily increasing over the last two decades. This study aimed to evaluate the effect of tumor location on gastric cancer prognosis. Materials and Methods: We retrospectively reviewed 2,466 patients who underwent gastrectomy for pathologically proven gastric cancer between January 2011 and December 2016. The patients were divided into an upper-third group (U group; n=419, 17.0%) and a middle- and lower-third group (ML group; n=2,047, 83.0%). Clinicopathological characteristics, overall survival (OS), and recurrence-free survival (RFS) alter surgery were compared. Results: The U group had more advanced disease than the ML group and a higher incidence of N3b disease for T3 (12.0% vs. 4.9%, p=0.023) and T4 tumors (33.3% vs. 17.5%, p=0.001). The 5-year RFS rate for stage III disease was marginally lower in the U group than that in the ML group (47.1% vs. 56.7%, p=0.082). The upper third location was an independent prognostic factor for both OS (hazard ratio [HR], 1.350; 95% confidence interval [CI], 1.065-1.711) and RFS (HR, 1.430; 95% CI, 1.080-1.823). Conclusions: Upper-third gastric cancer shows extensive node metastasis compared to those located more distally in >= T3 tumors. The upper third location is an independent prognostic factor for both OS and RFS and may have an adverse impact on RFS, particularly in patients with stage III gastric cancer. | Park, Ji Yeon; Kim, Eun Ji; Yang, Jae Yeong; Park, Ki Bum; Kwon, Oh Kyoung | Kyungpook Natl Univ, Chilgok Hosp, Dept Surg, 807 Hoguk Ro, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea | Park, Ji Yeon/AAV-2471-2020 | 57196405216; 58983790200; 58983956400; 57220965452; 26536109900 | jybark99@knu.ac.kr; | JOURNAL OF GASTRIC CANCER | J GASTRIC CANCER | 2093-582X | 2093-5641 | 24 | 2 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;ONCOLOGY | 2024 | 3.8 | 27.6 | 0.53 | 2025-05-07 | 2 | 2 | Stomach neoplasms; Gastric fundus; Gastrectomy; Prognosis; Survival analysis | TUMOR LOCATION; UNITED-STATES; ADENOCARCINOMA; CLASSIFICATION; COMPLICATIONS; DIAGNOSIS; KOREA | Gastrectomy; Gastric fundus; Prognosis; Stomach neoplasms; Survival analysis | tumor marker; adjuvant chemotherapy; aged; Article; cancer prognosis; cancer recurrence; cancer staging; cohort analysis; comparative study; computer assisted tomography; confidence interval; esophagogastroduodenoscopy; female; follow up; gastrectomy; histology; human; incidence; Kaplan Meier method; lymph node dissection; lymph node metastasis; major clinical study; male; multivariate analysis; overall survival; postoperative complication; prospective study; recurrence free survival; retrospective study; stomach cancer | English | 2024 | 2024-04 | 10.5230/jgc.2024.24.e3 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Development of Korean Representative Headforms for the Total Inward Leakage Testing on Filtering Facepiece Respirators | Background: The lack of headforms that accurately reflect the head characteristics of Koreans and the demographic composition of the Korean population can lead to inadequate FFR testing and reduced effectiveness of FFRs. Method: Direct measurements of 5,110 individuals and 3D measurements of 2,044 individuals, aged between 9 and 69 years, were sampled from the data pool of Size Korea surveys based on the age and gender ratios of the Korean resident demographics. Seven head dimensions were selected based on the ISO 16976-2, availability of Size Korea measurements, and their relevance to the fit performance of FFRs. A principal component analysis (PCA) was performed using the direct measurements to extract the main factors explaining the head characteristics and then the main factors were standardized and remapped to 3D measurements, creating five size categories representing Korean head shapes. Lastly, representative 3D headforms were constructed by averaging five head shapes for each size category. Results: The study identified two main factors explaining Korean head characteristics by the PCA procedure specified in ISO 16976-2 and developed five representative headforms reflecting the anthropometric features of Korean heads: medium, small, large, short & wide, and long & narrow. Conclusion: This study developed representative headforms tailored to the Korean population for conducting total inward leakage (TIL) tests on filtering facepiece respirators (FFRs). The representative headforms can be used for TIL testing by employing robotic headforms to enhance the performance of FFRs for the Korean target population. (c) 2023 Occupational Safety and Health Research Institute. Published by Elsevier B.V. on behalf of Institute, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/). | Lee, Ah Lam; Cui, Xin; Jung, Hayoung; Kim, Hee Eun; Jeon, Eun Jin; Na, Hyungjin; Kim, Eunmi; You, Heecheon | Kyungpook Natl Univ, Ctr Beautiful Aging, Dept Clothing & Text, Daegu, South Korea; Pohang Univ Sci & Technol, Dept Ind & Management Engn, Pohang, South Korea; Univ Michigan, Transportat Res Inst, Biosci Grp, Ann Arbor, MI USA; Gyeongbuk Technopk, Med Convergence Text Ctr, Gyeongsangbuk Do, South Korea; Pohang Univ Sci & Technol, Dept Ind & Management, Pohang 37673, South Korea | ; Jung, Hayoung/NBY-2147-2025; Lee, Ah Lam/AIB-3298-2022 | 57216704558; 57689108500; 57190617637; 55766543400; 54580989900; 58745260300; 58745883500; 7101663786 | hcyou@postech.ac.kr; | SAFETY AND HEALTH AT WORK | SAF HEALTH WORK-KR | 2093-7911 | 2093-7997 | 15 | 1 | SCIE;SSCI | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2024 | 2.9 | 27.6 | 0.65 | 2025-05-07 | 1 | 1 | Filtering facepiece respirator (FFR); Headform; Korean population; Total inward leakage (TIL) | DIGITAL 3-D HEADFORMS; FIT | Filtering facepiece respirator (FFR); Headform; Korean population; Total inward leakage (TIL) | adolescent; adult; aged; anthropometric parameters; Article; cephalometry; child; clinical assessment; clinical feature; controlled study; demographics; face; female; head; human; Korean Representative Headforms; male; measurement; middle aged; principal component analysis; program development; South Korea; total inward leakage testing | English | 2024 | 2024-03 | 10.1016/j.shaw.2023.11.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Energy-economic-environmental analysis of a net-zero energy greenhouse with fan-coil units and hot-water pipes: Experiment and modelling | This study analysed the performance of a hot-water pipe (HWP) and fan-coil units (FCUs) in controlling microclimate conditions in a net-zero energy greenhouse (NZEG). The performance of a previously developed TraNsient SYstem Simulation (TRNSYS) model for the NZEG was enhanced to include a crop model and several HWP emission standards, and the improved TRNSYS model was used to analyse heating, ventilation and air-conditioning (HVAC) systems for different greenhouse sizes in the Republic of Korea. Further, an economic analysis was conducted. The model validation showed excellent agreement between the measured and simulated values, with Nash-Sutcliffe efficiency of 0.98. The presence of crop in the simulation model reduced the total heating load by 14.5 MWh and increased the cooling load by 4 MWh. The capacity of the FCU was increased as the outside temperature rose from 33.4 celcius to 36.4 celcius in summer, and the diameter of the HWP was decreased from 25A to 10A as the outside temperature rose from -21.7 celcius to -12.2 celcius in winter to maintain the greenhouse at the desired temperature of 15 celcius . Notably, the payback period was reduced by 9 years when the annual savings in heating energy costs and revenue from carbon trading were considered as a part of the net economic cash flow. | Adesanya, Misbaudeen Aderemi; Na, Wook-Ho; Kim, Min-Hwi; Lee, Hyun-Woo | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Agr Civil Engn, Daegu, South Korea; Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu, South Korea; Korea Inst Energy Res, Renewable Energy Syst Lab, Daejeon, South Korea; Kyungpook Natl Univ, Dept Agr Civil Engn, 80 Daehak Ro, Daegu 41566, South Korea | Adesanya, Misbaudeen/AAA-4664-2022; Kim, Min-Hwi/S-9817-2018 | 57264527200; 57211208368; 55541423800; 57209160180 | whlee@knu.ac.kr; | INDOOR AND BUILT ENVIRONMENT | INDOOR BUILT ENVIRON | 1420-326X | 1423-0070 | 33 | 8 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH;ENGINEERING, ENVIRONMENTAL | 2024 | 2.9 | 27.6 | 2.49 | 2025-05-07 | 5 | 5 | Net-zero energy greenhouse; TraNsient SYstem simulation; Fan-coil units; Hot-water pipes; Crop; Heating pipe emission standards; Life cycle cost | PERFORMANCE; PREDICTION | Crop; Fan-coil units; Heating pipe emission standards; Hot-water pipes; Life cycle cost; Net-zero energy greenhouse; TraNsient SYstem simulation | carbon dioxide; hot water; kerosene; petroleum derivative; sugar; water; air conditioning; ant colony optimization; Article; chemical oxygen demand; cooling; economics; energy; environment; evapotranspiration; greenhouse; heating; human; humidity; lung ventilation; microclimate; photosynthesis; seasonal variation; simulation; solar radiation; thermal conductivity; validation process; wind speed | English | 2024 | 2024-10 | 10.1177/1420326x241246075 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Factors associated with gastric and duodenal neuroendocrine tumors: A multicenter case-control study | Background and Aims: The incidence of gastric and duodenal neuroendocrine tumors (GNET and DNET, respectively) is increasing, however associated factors of these diseases are not well known. Here, we investigated the factors associated with GNET and DNET. Methods: Patients with GNET and DNET presenting at eight tertiary referral centers between 2001 and 2020 were included and compared with healthy controls who underwent upper endoscopic screening. Clinical factors and laboratory data were analyzed to determine associated factors of GNET and DNET. Results: Overall, 396 patients with GNET and 193 patients with DNET were included and compared with 1725 healthy controls. Multivariate analysis showed that age (odds ratio [OR] 0.98), diabetes (OR 1.72), hypertension (OR 1.97), low serum high-density lipoprotein cholesterol (HDL-C) levels (OR 2.54), and past/present H. pylori infection (OR 1.46) were significantly associated with GNET. In contrast, DNET was significantly associated with diabetes (OR 1.80), hypertension (OR 1.68), low serum HDL-C levels (OR 2.29), and past/present H. pylori infection (OR 5.42). In the sex-based subgroup analysis in GNET, current smoking was strongly associated in women (OR 9.85), but not in men. Conclusions: This study identified several common metabolic factors associated with GNET and DNET. Additionally, some factors had sex-specific associations. (c) 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. | Nam, Kwangwoo; Nam, Su Youn; Park, Jun Chul; Cho, Young Sin; Choi, Hyuk Soon; Jung, Kyoungwon; Park, Seon-Young; Cho, Joon Hyun; Chun, Hyonho | Dankook Univ, Dankook Univ Hosp, Dept Gastroenterol, Coll Med, Cheonan, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Hematol Oncol, 807 Hoguk Ro, Daegu 702210, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Div Gastroenterol, Seoul, South Korea; Soonchunhyang Univ, Cheonan Hosp, Coll Med, Dept Internal Med,Div Gastroenterol, Cheonan, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Gastroenterol & Hepatol, Seoul, South Korea; Kosin Univ, Coll Med, Dept Internal Med, Div Gastroenterol, Busan, South Korea; Chonnam Natl Univ, Med Sch, Dept Internal Med, Gwangju, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Div Gastroenterol & Hepatol, Daegu, South Korea; Korea Adv Inst Sci & Technol KAIST, Dept Math Sci, Daejeon, South Korea | ; Park, Jordan Jun Chul/ABI-6276-2020 | 56650545300; 55617028500; 57226044317; 57212979518; 55581334800; 55267725300; 7501833800; 55515690700; 56678893000 | nam20131114@gmail.com; | DIGESTIVE AND LIVER DISEASE | DIGEST LIVER DIS | 1590-8658 | 1878-3562 | 56 | 9 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2024 | 3.8 | 27.6 | 0 | 2025-05-07 | 0 | 0 | Stomach; Duodenum; Neuroendocrine tumor; Associated factor | TERM-FOLLOW-UP; ENDOSCOPIC RESECTION; HELICOBACTER-PYLORI; RISK-FACTORS; PROGNOSTIC-FACTORS; CARCINOID-TUMORS; CANCER-RISK; MANAGEMENT; NEOPLASMS | Associated factor; Duodenum; Neuroendocrine tumor; Stomach | Adult; Aged; Case-Control Studies; Duodenal Neoplasms; Female; Helicobacter Infections; Helicobacter pylori; Humans; Hypertension; Male; Middle Aged; Neuroendocrine Tumors; Retrospective Studies; Risk Factors; Stomach Neoplasms; high density lipoprotein cholesterol; adult; Article; cancer screening; case control study; controlled study; diabetes mellitus; duodenal neuroendocrine tumor; endoscopy; female; gastric neuroendocrine tumor; Helicobacter infection; human; hypertension; major clinical study; male; middle aged; retrospective study; risk factor; smoking; tertiary care center; aged; blood; clinical trial; complication; duodenum tumor; epidemiology; Helicobacter pylori; multicenter study; neuroendocrine tumor; pathology; stomach tumor | English | 2024 | 2024-09 | 10.1016/j.dld.2024.01.210 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Quantification of whole-organ individual and bilateral renal metabolic rate of oxygen | Purpose: Renal metabolic rate of oxygen (rMRO(2)) is a potentially important biomarker of kidney function. The key parameters for rMRO(2) quantification include blood flow rate (BFR) and venous oxygen saturation (SvO(2)) in a draining vessel. Previous approaches to quantify renal metabolism have focused on the single organ. Here, both kidneys are considered as one unit to quantify bilateral rMRO(2). A pulse sequence to facilitate bilateral rMRO(2) quantification is introduced.Methods: To quantify bilateral rMRO(2), measurements of BFR and SvO(2) are made along the inferior vena cava (IVC) at suprarenal and infrarenal locations. From the continuity equation, these four parameters can be related to derive an expression for bilateral rMRO(2). The recently reported K-MOTIVE pulse sequence was implemented at four locations: left kidney, right kidney, suprarenal IVC, and infrarenal IVC. A dual-band variant of K-MOTIVE (db-K-MOTIVE) was developed by incorporating simultaneous-multi-slice imaging principles. The sequence simultaneously measures BFR and SvO(2) at suprarenal and infrarenal locations in a single pass of 21 s, yielding bilateral rMRO(2).Results: SvO(2) and BFR are higher in suprarenal versus infrarenal IVC, and the renal veins are highly oxygenated (SvO(2) >90%). Bilateral rMRO(2) quantified in 10 healthy subjects (8 M, 30 +/- 8 y) was found to be 291 +/- 247 and 349 +/- 300 (mu molO(2)/min)/100 g, derived from K-MOTIVE and db-K-MOTIVE, respectively. In comparison, total rMRO(2) from combining left and right was 329 +/- 273 (mu molO(2)/min)/100 g.Conclusion: The present work demonstrates that bilateral rMRO(2) quantification is feasible with fair reproducibility and physiological plausibility. The indirect method is a promising approach to compute bilateral rMRO(2) when individual rMRO(2) quantification is difficult. | Deshpande, Rajiv S.; Langham, Michael C.; Lee, Hyunyeol; Kamona, Nada; Wehrli, Felix W. | Univ Penn, Perelman Sch Med, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA; Kyungpook Natl Univ, Sch Elect & Elect Engn, Div AI & Signal Proc, Daegu, South Korea | 56938050100; 26326967200; 57193268117; 57208866181; 7007158575 | felix.wehrli@pennmedicine.upenn.edu; | MAGNETIC RESONANCE IN MEDICINE | MAGN RESON MED | 0740-3194 | 1522-2594 | 91 | 5 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2024 | 3 | 27.6 | 2.04 | 2025-05-07 | 4 | 4 | db-K-MOTIVE; K-MOTIVE; MOTIVE; renal oxygen metabolism; T-2-based oximetry; venous oxygen saturation | BLOOD-FLOW; CONSUMPTION; PULSE; CAIPIRINHA; SATURATION; HYPOXIA; WATER; TIME | db-K-MOTIVE; K-MOTIVE; MOTIVE; renal oxygen metabolism; T<sub>2</sub>-based oximetry; venous oxygen saturation | Humans; Kidney; Oximetry; Oxygen; Reproducibility of Results; Vena Cava, Inferior; Magnetic resonance; Metabolism; Oxygen; biological marker; oxygen; oxygen; Dual Band; Dual-band variant of K-MOTIVE; K-MOTIVE; MOTIVE; Oximetry; Oxygen metabolisms; Oxygen saturation; Renal oxygen metabolism; T2-based oximetry; Venoi oxygen saturation; adult; angiography; Article; blood flow velocity; brain blood flow; data analysis; female; flow rate; hematocrit; hemodynamics; human; human experiment; hypoxia; image analysis; image quality; image segmentation; inferior cava vein; kidney function; kidney metabolism; kidney vein; male; metabolic parameters; metabolic rate; normal human; nuclear magnetic resonance imaging; organ; oximetry; oxygen consumption; oxygen saturation; regression analysis; reproducibility; sensitivity analysis; venous oxygen tension; diagnostic imaging; kidney; metabolism; oximetry; procedures; Location | English | 2024 | 2024-05 | 10.1002/mrm.29981 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Analysis of Rice Blast Fungus Genetic Diversity and Identification of a Novel Blast Resistance OsDRq12 Gene | The rice blast fungus Magnaporthe oryzae poses a significant challenge to maintaining rice production. Developing rice varieties with resistance to this disease is crucial for its effective control. To understand the genetic variability of blast isolates collected between 2015 and 2017, the 27 monogenic rice lines that carry specific resistance genes were used to evaluate blast disease reactions. Based on criteria such as viability, virulence, and reactions to resistance genes, 20 blast isolates were selected as representative strains. To identify novel resistance genes, a quantitative trait locus analysis was carried out utilizing a mixture of the 20 representative rice blast isolates and a rice population derived from crossing the blast-resistant cultivar 'Cheongcheong' with the blast-susceptible cultivar 'Nagdong'. This analysis revealed a significant locus, RM1227-RM1261 on chromosome 12, that is associated with rice blast resistance. Within this locus, 12 disease resistance-associated protein genes were identified. Among them, OsDRq12, a member of the nucleotide-binding, leucine-rich repeat disease resistance family, was chosen as the target gene for additional computational investigation. The findings of this study have significant implications for enhancing rice production and ensuring food security by controlling rice blast and developing resistant rice cultivars. | Zhao, Dan-Dan; Chung, Hyunjung; Jang, Yoon-Hee; Farooq, Muhammad; Choi, Soo Yeon; Du, Xiao-Xuan; Kim, Kyung-Min | Natl Inst Crop Sci, Rural Dev Adm, Crop Fdn Res Div, Wonju 55365, South Korea; Natl Inst Agr Sci, Rural Dev Adm, Gene Engn Div, Jeonju 54874, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Yancheng Inst Technol, Coll Marine & Biol Engn, 211 Jianjun East Rd, Yancheng 224051, Jiangsu, Peoples R China; Kyungpook Natl Univ, Coastal Agr Res Inst, Daegu 41566, South Korea | ; Du, Xiaoxuan/AGZ-8638-2022; ZHAO, DANDAN/HIK-2130-2022; Kim, Kyung-Min Kim/C-7007-2014 | 57459517300; 55910719700; 57219901992; 59899372800; 57219911363; 57209098077; 34868260300 | haobingshuaike@hotmail.com;kkm@knu.ac.kr; | PHYTOPATHOLOGY | PHYTOPATHOLOGY | 0031-949X | 1943-7684 | 114 | 8 | SCIE | PLANT SCIENCES | 2024 | 3.1 | 27.7 | 1.69 | 2025-05-07 | 4 | 4 | Magnaporthe oryzae; monogenic rice lines; QTL; rice; rice blast | BROAD-SPECTRUM RESISTANCE; VIRULENCE; DISEASE; LOCUS | Magnaporthe oryzae; monogenic rice lines; QTL; rice; rice blast | Ascomycota; Disease Resistance; Genes, Plant; Genetic Variation; Magnaporthe; Oryza; Plant Diseases; Plant Proteins; Pyricularia oryzae; Quantitative Trait Loci; plant protein; Ascomycetes; disease resistance; genetic variation; genetics; immunology; Magnaporthe; Magnaporthe oryzae; microbiology; Oryza; pathogenicity; physiology; plant disease; plant gene; quantitative trait locus | English | 2024 | 2024-08 | 10.1094/phyto-02-24-0050-r | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | CRISPR-Cas9 System Mediated Genome Editing Technology: An Ultimate Tool to Enhance Abiotic Stress in Crop Plants | The drastic rise in the human population globally might uplift the issue of food scarcity in the coming few decades. This problem could affect the agricultural sector entirely, and to set targets for uplift, major issues like climate change and environmental stresses should be fixed for possible high crop production. To develop highly productive and resistant varieties using old traditional methods is now a waste of time, and fast practices like the use of genome editing tools are required. Among all the technological tools, CRISPR-Cas9 is the most precise, productive, and quickest system, with extensive usage to resist biotic and abiotic stresses. This technique has direct or indirect influence over quantitative genes to withstand abiotic shocks. More than 20 crops have been modified using CRISPR-Cas tools to withstand stresses and improve yield. Researchers are using CRISPR/Cas-based genome editing to improve staple crops for biotic and abiotic stress resistance and improved nutritional quality.Irrespective of rules regarding genetically modified organisms, CRISPR/Cas9 insert genes through agroinfiltration, viral infection, or preassembled Cas9 protein-sgRNA ribonucleoprotein transformation in crops without transgenic impression. Certain undesirable genes that result in starch degradation and maltose amassing were deleted by using CRISPR to reduce cold sensitivity. Precise noxious ion and metal removal from roots and their effective counterbalancing in protoplast notions to distant structures could also be managed through gene editing tools. Spindly gene knockout creates stress-tolerant (drought and salt) plants. Researchers can make cost-effective use of CRISPR technology in multiple sectors. The global population needs to be fed as climate change has severely affected food security, which could be overcome in the future through advancements in CRIPSR technology. | Mohamed, Heba I.; Khan, Ayesha; Basit, Abdul | Ain Shams Univ, Fac Educ, Dept Biol & Geol Sci, Cairo 1575, Egypt; Univ Agr, Fac Crop Prod Sci, Dept Hort, Peshawar 25120, Pakistan; Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea | ; Basit, Abdul/AAX-2414-2021; Khan, Ayesha/NKP-0640-2025; mohamed, heba/U-8673-2019 | 37102371200; 57199716425; 58696991300 | hebaibrahim79@gmail.com; | JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION | J SOIL SCI PLANT NUT | 0718-9508 | 0718-9516 | 24 | 2 | SCIE | ENVIRONMENTAL SCIENCES;PLANT SCIENCES;SOIL SCIENCE | 2024 | 3.1 | 27.7 | 1.59 | 2025-05-07 | 8 | 9 | CRISPR/Cas9; Cold stress; Drought stress; Heat stress; Heavy metal stress; Herbicide stress; Gene knockout | TRANSCRIPTION FACTORS; TARGETED MUTAGENESIS; HEAT TOLERANCE; HOMOLOGOUS RECOMBINATION; ASCORBATE PEROXIDASE; COLD TOLERANCE; ABSCISIC-ACID; RICE PLANTS; HUMAN-CELLS; GUIDE RNA | Cold stress; CRISPR/Cas9; Drought stress; Gene knockout; Heat stress; Heavy metal stress; Herbicide stress | English | 2024 | 2024-06 | 10.1007/s42729-024-01778-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Efficiency optimization of All-Inorganic perovskite solar cell device using NiOx and ZnO as charge transport layers | In this study, we have developed and refined an all-inorganic perovskite solar cell with the structure FTO/ZnO/ CsPbBr3/NiOx/Au. This was accomplished by incorporating the inorganic perovskite CsPbBr3 and the inorganic charge transport layers ZnO and NiOx. We employed solvent engineering techniques such as dropping solvents like isopropyl alcohol (IPA) and ethyl acetate (EA) during the spin-coating process, along with optimizing the thickness of the absorber layer and annealing conditions to enhance the power conversion efficiency (PCE). Our evaluation of the impact of the CsPbBr3 absorption layer thickness on PCE revealed that efficiency improved with layer thicknesses up to 280 nm. Moreover, we investigated the influence of post-deposition annealing durations on CsPbBr3, experimenting with times of 0.5hr, 1hr, 2hr, 3hr, and 5hr. The optimal conversion efficiency of 0.91 % was attained with an annealing temperature of 225 degrees C for 2hr, particularly when the absorption layer thickness was set at 280 nm. These results suggest that the device structure optimization for all-inorganic perovskite quantum dot solar cells can be successfully applied for efficiency optimization. | Son, Hyojung; Heo, Young-Woo; Jeong, Byoung-Seong | Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Adv Mat Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | 57902836700; 7004298542; 35895071700 | gatorever@knu.ac.kr; | SOLAR ENERGY | SOL ENERGY | 0038-092X | 1471-1257 | 281 | SCIE | ENERGY & FUELS | 2024 | 6.6 | 27.7 | 0.5 | 2025-05-07 | 0 | 2 | All-Inorganic; Perovskite; ZnO; NiOx; Solar Cell | CSPBBR3 PEROVSKITE; QUANTUM DOTS; NANOCRYSTALS; STABILITY; SOLVENT | All-Inorganic; NiO<sub>x</sub>; Perovskite; Solar Cell; ZnO | Cell engineering; Nanocrystals; Perovskite; Selenium compounds; Semiconductor quantum dots; Solar absorbers; Tellurium compounds; Absorption layer; All-inorganic; Charge transport layer; Efficiency optimization; Inorganics; Layer thickness; NiOx; Power conversion efficiencies; Solar cell devices; ZnO; absorption; efficiency measurement; fuel cell; optimization; performance assessment; perovskite; solvent; temperature effect; Spin coating | English | 2024 | 2024-10 | 10.1016/j.solener.2024.112892 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Recent Advances in Biochemical Reprogramming Network Under Drought Stress in Soybean | Global climatic changes and the increasing human population have severely threatened global food security. Under abiotic stresses, metabolic reprogramming is crucial in cytosolic osmotic regulation. Therefore, biochemical characterization and profiling are essential to understand the physio-molecular responses of plants to environmental stress, such as drought stress. Drought stress is one of the major abiotic stresses that challenge the sustainability of crop production systems. Soybean is an important food legume crop that is sensitive to drought stress. In this review, we discuss the effects of drought stress on soybean and its associated biochemical reprogramming for optimizing plant production under stressful environments. The role of metabolites in the metabolic reprogramming within the cell during drought stress has also been described. Such diverse biochemical reprogramming is required for systemic acquired acclimation to drought stress in soybean. | Shaffique, Shifa; Farooq, Muhammad; Kang, Sang-Mo; Lee, In-Jung | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Sultan Qaboos Univ, Coll Agr & Marine Sci, Dept Plant Sci, Al Khoud, Muscat 123, Oman | ; Kang, Sang-Mo/MBG-7823-2025; Lee, In-Jung/GLS-0432-2022; shaffique, shifa/KUC-7102-2024; Muhammad, Farooq/KMY-9001-2024 | 57203898867; 56260585600; 56189696900; 16425830900 | farooqcp@squ.edu.om;ijlee@knu.ac.kr; | JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION | J SOIL SCI PLANT NUT | 0718-9508 | 0718-9516 | 24 | 2 | SCIE | ENVIRONMENTAL SCIENCES;PLANT SCIENCES;SOIL SCIENCE | 2024 | 3.1 | 27.7 | 1.19 | 2025-05-07 | 6 | 6 | TCA; sugar; Metabolomics; Reactive oxygen species; Secondary metabolites | PROLINE ACCUMULATION; PROTEOMIC ANALYSIS; ANTIOXIDANT METABOLISM; PHENOTYPIC PLASTICITY; WATER-STRESS; GLYCINE-MAX; SHORT-TERM; TOLERANCE; PLANTS; OSMOREGULATION | Metabolomics; Reactive oxygen species; Secondary metabolites; TCA; sugar | English | 2024 | 2024-06 | 10.1007/s42729-024-01711-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Association of Basic Psychological Need Fulfillment and School Happiness with Obesity Levels and Intensity of Physical Activity during Physical Education Classes in South Korean Adolescents | This study examined the relationship between basic psychological need fulfillment (BPNF) and school happiness in relation to the intensity of physical activity exhibited by adolescents during physical education (PE) classes and their obesity levels. We measured BPNF and school happiness using a questionnaire administered to 600 junior high school students. After exclusion, 532 questionnaires were analyzed. A 3D accelerometer (GT3X model) from Actigraph and the body mass index were used to measure physical activity intensity and obesity, respectively. The findings of this study indicate that BPNF and school happiness were significantly associated with physical activity intensity. Specifically, students who engaged in high-intensity physical activity exhibited higher levels of BPNF and school happiness. Additionally, BPNF and school happiness were not significantly related to obesity, whereas a significant relationship was observed between BPNF, school happiness, and the interaction between physical activity intensity and obesity level. This finding implies that adolescents with higher physical activity intensity and lower obesity reported higher levels of BPNF and school happiness. These findings suggest that physical activity intensity during PE classes significantly influences emotional development. Therefore, incorporating moderate-to-vigorous physical activity into PE may serve as a strategy for promoting emotional development in adolescents. | Yun, Ju-Seok; Lee, Gyu-Il; Kim, Bo-Ram | Korea Univ, Dept Phys Educ, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Phys Educ, Daegu 41566, South Korea | 58362133900; 58118889300; 57220036010 | tennis2667@korea.ac.kr;mauri94@knu.ac.kr;brh@naver.com; | HEALTHCARE | HEALTHCARE-BASEL | 2227-9032 | 12 | 1 | SCIE;SSCI | HEALTH CARE SCIENCES & SERVICES;HEALTH POLICY & SERVICES | 2024 | 2.7 | 27.8 | 1.67 | 2025-04-16 | 2 | 2 | school happiness; basic psychological need fulfillment; intensity of physical activity; obesity level; moderate-to-vigorous physical activity | SELF-DETERMINATION THEORY; QUALITY-OF-LIFE; CHILDREN; HEALTH; CHILDHOOD; PERCEPTIONS; OVERWEIGHT; DEPRESSION; EXERCISE; STUDENTS | basic psychological need fulfillment; intensity of physical activity; moderate-to-vigorous physical activity; obesity level; school happiness | English | 2024 | 2024-01 | 10.3390/healthcare12010040 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Changes in Pediatric End-of-Life Process After the Enforcement of the Act on Life-Sustaining Treatment Decisions-The Experience of a Single Children's Hospital | Background: The Act on Life-Sustaining Treatment (LST) for patients at the end of life (the Korean LST Decision Act), implemented in the Republic of Korea in February 2018, has led to changes in the end-of-life decision-making (EOLDM) process in children. This study aimed to investigate changes in pediatric EOLDM process and LST practices since the Korean LST Decision Act. Methods: This retrospective cohort study included 107 patients who died at Kyungpook National University Children's Hospital from January 2015 to December 2020. Patients were divided into two groups: pre-law (January 2015-January 2018, n = 55) and post-law (February 2018-December 2020, n = 52). We analyzed medical records for EOLDM process, patient characteristics, intensive care unit (ICU) admission, documentation types, and LST withholding or withdrawal decisions. Results: After the Korean LST Decision Act, the median total hospitalization duration decreased significantly (14 days [IQR, 3-80] vs. 6 days [IQR, 2-18], p = 0.020), as did the median ICU length of stay (3 days [IQR 1-33] vs. 2.5 days [IQR 1-10.3], p = 0.002). The time from admission to end-of-life decision documentation was significantly shorter in group 2 (6 days [IQR 1-31] vs. 4 days [IQR 1-9], p = 0.027). The use of physician orders for life-sustaining treatment (POLST) documents increased (0% to 33.3%), while do-not-resuscitate (DNR) orders decreased (85.3% to 16.7%). Notably, LST withdrawal decisions increased from 0% to 27.8% (p = 0.001) in the post-legislation period. Conclusions: The Korean LST Decisions Act has led to significant changes in the EOLDM process for terminally ill children, including earlier decision-making, increased use of POLST documents, more frequent LST withdrawal decisions, and shorter hospital and ICU stays. These findings suggest a shift towards more structured and timely end-of-life care discussions in pediatric settings. | Roh, Da-Eun; Kwon, Jung-Eun; Lim, Young-Tae; Kim, Yeo-Hyang | Inje Univ, Busan Paik Hosp, Coll Med, Dept Pediat, Busan 47392, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu 41944, South Korea; Kyungpook Natl Univ, Childrens Hosp, Pediat Palliat Care Ctr, Daegu 41404, South Korea | 57195734230; 57194002366; 57197274340; 57032023800 | ponyks1004@naver.com;lovecello623@gmail.com;ytlim@knuh.kr;kimyhmd@knu.ac.kr; | HEALTHCARE | HEALTHCARE-BASEL | 2227-9032 | 12 | 21 | SCIE;SSCI | HEALTH CARE SCIENCES & SERVICES;HEALTH POLICY & SERVICES | 2024 | 2.7 | 27.8 | 0 | 2025-05-07 | 1 | 0 | terminal care; palliative care; advance directives; withholding treatment; children | CARDIOPULMONARY-RESUSCITATION; WITHDRAWAL; CARE | advance directives; children; palliative care; terminal care; withholding treatment | English | 2024 | 2024-11 | 10.3390/healthcare12212156 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Deep electroacupuncture of neurogenic spots attenuates immobilization stress-induced acute hypertension in rats | Background: Our previous studies proved that neurogenic inflammatory spots (or neurogenic spots) have the same physiological features as acupuncture points and that neurogenic spot stimulation generates therapeutic effects in various animal models. However, it is unclear how deeply the neurogenic spots should be stimulated to generate therapeutic effects. Methods: The effects of acupuncture at various needle depths below the neurogenic spot were examined in a rat immobilization stress-induced hypertension (IMH) model. Electroacupuncture was applied to a neurogenic spot at depths of 1, 2, or 3 mm using a concentric bipolar electrode. Results: Electrical stimulation of the neurogenic spot at a 3 -mm depth most effectively lowered blood pressure compared with controls and stimulation at 1- and 2 -mm depths, which was inhibited by pretreatment with a local anesthetic lidocaine. Electrical stimulation of the neurogenic spot or injection of substance P (SP) at a 3 -mm depth significantly excited the rostral ventrolateral medulla (rVLM) compared with superficial stimulation. Electrical stimulation applied at a 3 -mm depth on neurogenic spots dominantly caused c-fos expression from rVLM and ventrolateral periaqueductal gray (vlPAG) in IMH rats. Pretreatment with resiniferatoxin (RTX) injection into the neurogenic spot to ablate SP or calcitonin gene-related peptide (CGRP) prevented the effects of 3 -mm neurogenic spot stimulation on blood pressure in IMH rats. Conversely, artificial injection of SP or CGRP generated antihypertensive effects in IMH rats. Conclusion: Our data suggest that neurogenic spot stimulation at a 3 -mm depth generated anti-hypertensive effects through the local release of SP and CGRP and activation of rVLM and vlPAG. | Zhan, Cong; Jang, Han Byeol; Ahn, Danbi; Chang, Suchan; Ryu, Yeonhee; Kim, Hyung Kyu; Lee, Bong Hyo; Guan, Xiaowei; Fan, Yu; Lee, Bae Hwan; Kim, Hee Young | Yonsei Univ, Coll Med, Dept Physiol, Seoul, South Korea; Daegu Haany Univ, Coll Korean Med, Dept Physiol, Daegu, South Korea; Korea Inst Oriental Med, Korean Med Fundamental Res Div, Daejeon, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Physiol, Taegu, South Korea; Nanjing Univ Chinese Med, Dept Human Anat & Histoembryol, Nanjing, Peoples R China; Yonsei Univ Coll Med, Dept Physiol, Seoul 03722, South Korea | ; Kim, Hee/ABH-9670-2020; Kim, Hyung/J-5451-2012 | 58817560700; 57214789091; 57222303784; 56208951400; 8673843500; 57208751988; 22938054300; 23469178600; 59065751400; 57216391271; 57205024859 | heeykim@yuhs.ac; | INTEGRATIVE MEDICINE RESEARCH | INTEGR MED RES | 2213-4220 | 2213-4239 | 13 | 1 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE | 2024 | 3 | 27.8 | 0.92 | 2025-05-07 | 1 | 1 | Immobilization stress-induced hypertension | ROSTRAL VENTROLATERAL MEDULLA; PERIAQUEDUCTAL GRAY; C-FOS; MECHANISMS; PAIN; INFLAMMATION | Acupuncture; Immobilization stress-induced hypertension; Neurogenic inflammatory spot; Rostral ventrolateral medulla; Ventrolateral periaqueductal gray | calcitonin gene related peptide; Evans blue; isoflurane; lidocaine; protein c fos; resiniferatoxin; substance P; urethan; acupuncture point; animal experiment; animal model; animal tissue; antihypertensive activity; Article; blood pressure measurement; blood pressure regulation; controlled study; electroacupuncture; electrostimulation; firing rate; fluorescence intensity; hypertension; immobilization stress; immunohistochemistry; local anesthesia; male; nerve cell excitability; neurogenic inflammation; nonhuman; rat; rostral ventrolateral medulla; sensory nerve; systolic blood pressure; ventrolateral periaqueductal gray | English | 2024 | 2024-03 | 10.1016/j.imr.2023.101006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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