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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Influence of Lingual Tonsillar Volume in Patients with Obstructive Sleep Apnea | This study aimed to evaluate the influence of lingual tonsil (LT) volume measured using a three-dimensional (3D) reconstruction volume rendering program on clinical parameters and polysomnography (PSG) results. A total of 100 patients who underwent PSG, computed tomography (CT), and allergy test from April 2016 to April 2020 were randomly selected. LT volume was measured using an imaging software program that enables 3D reconstruction of CT images. PSG parameters were analyzed by dividing the subjects into two groups according to LT volume (each 50 people). Based on the medial volume of 0.863 cm(3), the upper half LT volume group and the lower half LT volume group were analyzed. Clinical factors such as body weight, neck circumference, body mass index (BMI), and age showed no difference between the two groups. Among PSG parameters, supine arousal index and non-rapid eye movement (NREM) arousal index were significantly higher in the upper half LT volume group (p = 0.012, 0.037). However, there was no significant difference in apnea-hypopnea index (AHI) between the upper and lower half LT volume groups (p = 0.749). Arousal snoring index and REM arousal index also showed no difference between the two groups. The prevalence of allergic rhinitis was not different in the two groups. High LT volume is associated with NREM arousal and arousal in the supine position, but it is not related to AHI. | Kang, Yung Jee; Kim, Byung Kil; Hong, Sang Duk; Jung, Yong Gi; Ryu, Gwanghui; Kim, Hyo Yeol | Sungkyunkwan Univ, Samsung Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Sch Med, Seoul 06351, South Korea; Kyungpook Natl Univ, Dept Otorhinolaryngol Head & Neck Surg, Chilgok Hosp, Daegu 41404, South Korea | ; Ryu, Gwanghui/MGW-2108-2025; Kim, Hyo Yeol/HLP-5150-2023 | 57216933365; 57469397400; 24072844200; 23025412600; 55601888200; 7410127775 | ghryu379@gmail.com;siamkhy@gmail.com; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 12 | 11 | SCIE | BIOLOGY | 2022 | 3.2 | 36.4 | 0.12 | 2025-06-25 | 2 | 1 | lingual tonsil volume; polysomnography; obstructive sleep apnea | REFLUX SYMPTOM INDEX; HYPERTROPHY; ADULTS; BASE; FAT | lingual tonsil volume; obstructive sleep apnea; polysomnography | English | 2022 | 2022-11 | 10.3390/life12111920 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Isolation and identification of metronidazole resistance Helicobacter pylori from gastric patients in the southeastern region of India and its advanced antibacterial treatment using biological silver oxide nanoparticles | The present study aimed to identify the drug resistance Helicobacter pylori (H. pylori), and its advanced treatment using Digiria muricata (Dm) leaf mediated silver oxide nanoparticles (Ag2ONPs). The synthesized Dm-Ag2ONPs were confirmed by UV-visible spectrometry, X-ray diffraction crystallography (XRD), Fourier transfer infrared spectroscopy (FT-IR), Transmission electron microscopy (TEM), Energy dispersive spectroscopy (EDAX). The fifty gastric biopsy samples were obtained from gastric patients in the Trichy SRM medical College Hospital and Research Centre, Central South-Eastern region of India, Trichy with Gastro endoscopy. H. pylori was identified by biopsy crush cytology, histopathology, rapid urease test, and biochemical tests. The resistance pattern was checked by the disk diffusion method. Among 50 biopsy samples, ten patients had positive results for culture, biochemical, and histopathology. The obtained strains showed 10% resistance to the metronidazole and 100% sensitivity toward amoxicillin and clarithromycin. Further, the metronidazole resistance strain was tested against Dm-Ag2ONPs using a well diffusion assay, which showed (25 mu g/mL) 2.4 +/- 0.4 and (100 mu g/mL) 5.5 +/- 0.5 mm antibacterial activity. Overall, the obtained results from the present investigation are promising enough to revels the effectiveness of Dm-Ag2ONPs to inhibit the metronidazole resistance H. pylori, this may help to develop a novel therapeutic drug against the drug resistance H. pylori infections. | Sampath, Gattu; Govarthanan, Muthusamy; Krishnamurthy, Sridharan; Nagarajan, Prabhusaran; Rameshkumar, Neelamegam; Krishnan, Muthukalingan; Nagarajan, Kayalvizhi | Periyar Univ, Dept Zool, Salem, India; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hospital, Dept Biomat, Chennai 600077, India; Tamilnadu Dr MGR Med Univ, Trichy SRM Med Coll Hosp & Res Ctr, Dept Microbiol & Gastroenterol, Tiruchirapalli, India; Cent Univ Tamil Nadu, Thiruvarur 610005, Tamil Nadu, India; Amity Univ, Amity Inst Biotechnol AIB, Mumbai, Maharashtra, India | Govarthanan, Muthusamy/C-1491-2014; kayalvizhi, nagarajan/D-8742-2011; Muthusamy, Govarthanan/C-1491-2014 | 57216919716; 54881927600; 57681484700; 57212634421; 35173727100; 7102069651; 57215224341 | kayal@periyaruniversity.ac.in; | BIOCHEMICAL ENGINEERING JOURNAL | BIOCHEM ENG J | 1369-703X | 1873-295X | 187 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;ENGINEERING, CHEMICAL | 2022 | 3.9 | 36.4 | 0.37 | 2025-06-25 | 5 | 5 | Silver oxide nanoparticles; Gastrointestinal disease; Helicobacter pylori; Histopathology; Metronidazole | ANTIMICROBIAL SUSCEPTIBILITY; BIOSYNTHESIS | Gastrointestinal disease; Helicobacter pylori; Histopathology; Metronidazole; Silver oxide nanoparticles | Biopsy; Cells; Cytology; Drug delivery; Energy dispersive spectroscopy; High resolution transmission electron microscopy; Infrared spectroscopy; Nanoparticles; Oxides; Silver oxides; X ray crystallography; antiinfective agent; Digiria muricata leaf extract; metal nanoparticle; metronidazole; plant extract; silver oxide nanoparticle; unclassified drug; Advanced treatment; Antibacterial treatment; Biopsy samples; Drug-resistance; Gastrointestinal Disease; Helicobacter pylori; Histopathology; Isolation and identification; Metronidazole; Silver oxide nanoparticles; adult; aged; Amaranthaceae; antibacterial activity; antibiotic resistance; antibiotic sensitivity; antibiotic therapy; Article; bacterial strain; bacterium culture; bacterium identification; bacterium isolate; biochemical analysis; biosynthesis; clinical article; controlled study; cytology; demographics; Digiria muricata; disk diffusion; endoscopy; energy dispersive X ray spectroscopy; female; Fourier transform infrared spectroscopy; gastrointestinal disease; Giemsa stain; Helicobacter infection; Helicobacter pylori; histopathology; human; human tissue; India; male; medicinal plant; multidrug resistant bacterium; nonhuman; plant leaf; stomach biopsy; transmission electron microscopy; ultraviolet visible spectroscopy; X ray crystallography; X ray diffraction; Strain | English | 2022 | 2022-11 | 10.1016/j.bej.2022.108445 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | LENS-GRM Applicability Analysis and Evaluation | Recently, there have been many abnormal natural phenomena caused by climate change. Anthropogenic factors associated with insufficient water resource management can be another cause. Among natural causes, rainfall intensity and volume often induce flooding. Therefore, accurate rainfall estimation and prediction can prevent and mitigate damage caused by these hazards. Sadly, uncertainties often hinder accurate rainfall forecasting. This study investigates the uncertainty of the Korean rainfall ensemble prediction data and runoff analysis model in order to enhance reliability and improve prediction. The objectives of this study include: (i) evaluating the spatial characteristics and applicability of limited area ensemble prediction system (LENS) data; (ii) understanding uncertainty using parameter correction and generalized likelihood uncertainty estimation (GLUE) and grid-based rainfall-runoff model (GRM); (iii) evaluating models before and after LENS-GRM correction. In this study, data from the Wicheon Basin was used. The informal likelihood (R2, NSE, PBIAS) and formal likelihood (log-normal) were used to evaluate model applicability. The results confirmed that uncertainty of the behavioral model exists using the likelihood threshold when applying the runoff model to rainfall forecasting data. Accordingly, this method is expected to enable more reliable flood prediction by reducing the uncertainties of the rainfall ensemble data and the runoff model when selecting the behavioral model for the user's uncertainty analysis. It also provides a basis for flood prediction studies that apply rainfall and geographical characteristics for rainfall-runoff uncertainty analysis. | Lee, Sanghyup; Seong, Yeonjeong; Jung, Younghun | Univ Illinois, Dept Agr & Biol Engn, Urbana, IL 61801 USA; Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, 2559 Gyeongsangdaero, Sangju 37224, Gyeongbuk, South Korea | 57839879500; 57202956507; 55195880200 | y.jung@knu.ac.kr; | WATER | WATER-SUI | 2073-4441 | 14 | 23 | SCIE | ENVIRONMENTAL SCIENCES;WATER RESOURCES | 2022 | 3.4 | 36.4 | 0.11 | 2025-06-25 | 0 | 1 | uncertainty analysis; rainfall-runoff modeling; rainfall estimation; LENS; GLUE; GRM | UNCERTAINTY; MODEL | GLUE; GRM; LENS; rainfall estimation; rainfall-runoff modeling; uncertainty analysis | Behavioral research; Climate change; Floods; Glues; Gluing; Rain; Reliability analysis; Runoff; Water management; Weather forecasting; Ensemble prediction systems; Generalized likelihood uncertainty estimation; Grid-based; Grid-based rainfall-runoff model; Limited area ensemble prediction system; Rainfall - Runoff modelling; Rainfall estimations; Rainfall forecasting; Uncertainty; correction; geographical characteristics; precipitation intensity; rainfall-runoff modeling; uncertainty analysis; Uncertainty analysis | English | 2022 | 2022-12 | 10.3390/w14233897 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Prognostic Impact and Predictors of New-Onset Atrial Fibrillation in Heart Failure | Background: The prognostic impact and predictors of NOAF in HF patients are not fully elucidated. This study aims to determine whether new-onset atrial fibrillation (NOAF) affects patient outcome and investigate predictors of atrial fibrillation (AF) in acute heart failure (HF) patients using real-world data. Methods: The factors associated with NOAF in 2894 patients with sinus rhythm (SR) enrolled in the Korean Acute Heart Failure (KorAHF) registry were investigated. Survival was analyzed using AF as a time-dependent covariate. Relevant predictors of NOAF were analyzed using multivariate proportional hazards models. Results: Over 27.4 months, 187 patients developed AF. The median overall survival time was over 48 and 9.9 months for the SR and NOAF groups, respectively. Cox regression analysis with NOAF as a time-dependent covariate showed a higher risk of death among patients with NOAF. Multivariate Cox modeling showed that age, worsening HF, valvular heart disease (VHD), loop diuretics, lower heart rate, larger left atrium (LA) diameter, and elevated creatinine levels were independently associated with NOAF. Risk score indicated the number of independent predictors. The incidence of NOAF was 2.9%, 9.4%, and 21.8% in the low-risk, moderate-risk, and high-risk groups, respectively (p < 0.001). Conditional inference tree analysis identified worsening HF, heart rate, age, LA diameter, and VHD as discriminators. Conclusions: NOAF was associated with decreased survival in acute HF patients with SR. Age, worsening HF, VHD, loop diuretics, lower heart rate, larger LA diameter, and elevated creatinine could independently predict NOAF. This may be useful to risk-stratify HF patients at risk for AF. | Choi, Hyo-In; Lee, Sang Eun; Kim, Min-Seok; Lee, Hae-Young; Cho, Hyun-Jai; Choi, Jin Oh; Jeon, Eun-Seok; Hwang, Kyung-Kuk; Chae, Shung Chull; Baek, Sang Hong; Kang, Seok-Min; Choi, Dong-Ju; Yoo, Byung-Su; Kim, Kye Hun; Cho, Myeong-Chan; Oh, Byung-Hee; Kim, Jae-Joong | Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Cardiol,Sch Med, Seoul 03181, South Korea; Univ Ulsan, Asan Med Ctr, Dept Internal Med, Div Cardiol,Coll Med, Seoul 05505, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Div Cardiol, Seoul 03080, South Korea; Sungkyunkwan Univ, Dept Internal Med, Div Cardiol, Coll Med, Seoul 06351, South Korea; Chungbuk Natl Univ, Dept Internal Med, Div Cardiol, Coll Med, Cheongju 28644, South Korea; Kyungpook Natl Univ, Dept Internal Med, Div Cardiol, Coll Med, Daegu 41944, South Korea; Catholic Univ Republ Korea, Dept Internal Med, Div Cardiol, Seoul 03083, South Korea; Yonsei Univ, Dept Internal Med, Div Cardiol, Coll Med, Seoul 03722, South Korea; Seoul Natl Univ, Bundang Hosp, Div Cardiol, Cardiovasc Ctr, Seongnam 13620, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Div Cardiol, Wonju 26426, South Korea; Chonnam Natl Univ, Heart Res Ctr, Gwangju 61469, South Korea | Oh, Byung-Hee/G-9875-2011; Kim, Kyung-Hee/JBI-8300-2023; Choi, Dong-Ju/J-5686-2012; LEE, JI/L-6920-2013; Lee, Hye-Young/JEP-8044-2023; Jeong, Gi/AAB-2830-2021; Kim, Soo-Yeon/ADR-9663-2022; Choi, Joon/D-6140-2017 | 36877359500; 57207065107; 57212315719; 56151235500; 35285421400; 15848011800; 7004279641; 7402426370; 7101962036; 7201371594; 7405685375; 35274349200; 7102851884; 56150430800; 7401727518; 57216293873; 36065764100 | drhyoin.choi@samsung.com;sangeunlee.md@gmail.com;guess124@gmail.com;hylee612@snu.ac.kr;hyunjaicho@snu.ac.kr;jinoh.choi@samsung.com;esjeon@skku.edu;kyungkukhwang@gmail.com;scchae@knu.ac.kr;whitesh@catholic.ac.kr;smkang@yumc.yonsei.ac.kr;djchoi@snu.ac.kr;yubs@yonsei.ac.kr;christiankyehun@hanmail.net;mccho@chungbuk.ac.kr;ohbhmed@snu.ac.kr;jjkim@amc.seoul.kr; | LIFE-BASEL | LIFE-BASEL | 2075-1729 | 12 | 4 | SCIE | BIOLOGY | 2022 | 3.2 | 36.4 | 0.48 | 2025-06-25 | 4 | 4 | atrial fibrillation; heart failure; mortality; risk factors; registries | RISK | atrial fibrillation; heart failure; mortality; registries; risk factors | English | 2022 | 2022-04 | 10.3390/life12040579 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Adalimumab in Pediatric Inflammatory Bowel Disease | The introduction of biological agents with strong anti-inflammatory action, such as antitumor necrosis factor (TNF) agents, has changed inflammatory bowel disease (IBD) treatment strategy and goals, and has contributed significantly to improve the long-term prognosis of patients. Moreover, several biological agents are being used or researched in pediatric populations. However, only two biological agents, infliximab (IFX) and adalimumab (ADL), are currently approved for children and adolescents. In pediatric IBD, there are limitations and burdens associated with facilitating mucosal healing (MH) when utilizing these two biological agents. ADL is effective in both naive patients and those with previous experience with biologics. Beyond clinical remission, this drug is also effective for MH and histological remission. The use of therapeutic drug monitoring to further enhance the effectiveness of ADL treatment can be expected to reduce treatment failure of ADL and pave the way for appropriate treatment in the treat-to-target era. This review paper focuses on ADL, examine studies conducted in children, and determine the role this agent plays against pediatric inflammatory bowel disease. | Choi, So Yoon; Kang, Ben | Kosin Univ, Gospel Hosp, Coll Med, Dept Pediat, Pusan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea | 康, 奔/JMQ-0812-2023 | 57207282105; 57194823199 | benkang@knu.ac.kr; | FRONTIERS IN PEDIATRICS | FRONT PEDIATR | 2296-2360 | 10 | SCIE | PEDIATRICS | 2022 | 2.6 | 36.5 | 0.49 | 2025-06-25 | 3 | 5 | adalimumab; biologics; inflammatory bowel disease; Crohn's disease; ulcerative colitis; child | ANTITUMOR NECROSIS FACTOR; SEVERE CROHNS-DISEASE; POST-HOC ANALYSIS; COMBINATION THERAPY; CLINICAL REMISSION; BIOLOGICAL THERAPY; INFLIXIMAB THERAPY; BRITISH SOCIETY; NATURAL-HISTORY; FOLLOW-UP | adalimumab; biologics; child; Crohn's disease; inflammatory bowel disease; ulcerative colitis | adalimumab; biological product; immunomodulating agent; activity of daily living assessment; arthralgia; Crohn disease; drug efficacy; drug indication; drug monitoring; fistula; gastrointestinal endoscopy; histopathology; human; infection; inflammatory bowel disease; injection site reaction; myalgia; pediatric patient; psoriasis; remission; Review; ulcerative colitis; upper respiratory tract infection | English | 2022 | 2022-04-13 | 10.3389/fped.2022.852580 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Development of Spinal Tuberculosis in an Adolescent With Crohn's Disease After Infliximab Therapy: A Case Report With Literature Review | IntroductionTuberculosis (TB) spondylitis, also known as Pott's disease, is a severe form of extrapulmonary TB. Infliximab treatment for Crohn's disease (CD) patients increases the risk of TB, and is likely to increase the risk of TB spondylitis as well. Case PresentationWe report a rare case of TB spondylitis development in a 16-year-old female with CD. She had a close household contact of active pulmonary TB and received contact investigation. She was diagnosed with latent TB 1 month before the diagnosis of CD, and had started a latent TB treatment regimen with isoniazid for 9 months. At 5 months from the start of latent TB treatment, infliximab was started. Approximately 1 year after infliximab treatment, her infusion interval was shortened from every 8 weeks to every 4 weeks owing to secondary loss of response due to nonimmunogenic pharmacokinetic failure. One month later, miliary TB developed and infliximab was stopped. She received a miliary TB treatment regimen for 6 months, curing the disease. Three months later, spinal TB was incidentally detected on abdominal computed tomography. She received a TB treatment regimen for 12 months, curing spinal TB. Currently, she is receiving vedolizumab to treat CD and is in clinical remission. Although this patient has sufficiently been treated at each stage of TB development, particularly for latent TB and miliary TB, TB spondylitis still developed. ConclusionConsidering that TB spondylitis developed despite sufficient treatment at each stage, pediatric gastroenterologists should stay cautious when using anti-tumor necrosis factor agents in patients with inflammatory bowel disease with a history of latent TB. | Jung, Jae Hoon; Choi, Sujin; Kang, Youra; Cho, Dae-Chul; Lee, So Mi; Park, Tae In; Choe, Byung-Ho; Kim, Dongsub; Kang, Ben | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ Daegu, Sch Med, Dept Pathol, Daegu, South Korea | 康, 奔/JMQ-0812-2023; Choe, Byung-Ho/KSM-6251-2024 | 57246413500; 57223972405; 57464178600; 55859543400; 56824903400; 7401801814; 57574977300; 57205248455; 57194823199 | kds@knu.ac.kr;benkang@knu.ac.kr; | FRONTIERS IN PEDIATRICS | FRONT PEDIATR | 2296-2360 | 9 | SCIE | PEDIATRICS | 2022 | 2.6 | 36.5 | 0.4 | 2025-06-25 | 3 | 3 | Pott's disease; Crohn's disease; tuberculosis; tumor necrosis factor; infliximab; vedolizumab | INFLAMMATORY-BOWEL-DISEASE; TUMOR-NECROSIS-FACTOR; ASIA-PACIFIC ASSOCIATION; GASTROENTEROLOGY CONSENSUS; MAINTENANCE THERAPY; INFECTION; RISK; RECOMMENDATIONS; ORGANIZATION; REACTIVATION | Crohn's disease; infliximab; Pott's disease; tuberculosis; tumor necrosis factor; vedolizumab | adalimumab; azathioprine; ethambutol; infliximab; isoniazid; mesalazine; methotrexate; pyrazinamide; rifampicin; vedolizumab; adolescent; Article; case report; clinical article; computer assisted tomography; contact examination; Crohn disease; drug withdrawal; enteric feeding; family history; female; human; ileocolonoscopy; latent tuberculosis; lung tuberculosis; medical history; miliary tuberculosis; remission; thorax radiography; tuberculous spondylitis | English | 2022 | 2022-02-09 | 10.3389/fped.2021.802298 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effect of initiator on the catalytic performance of zinc(II) complexes supported by aminomethylquinoline and aminomethylpyridine derived ligands in stereoselective ring opening polymerization of rac-lactide | Zinc(II) complexes, namely [LnZnCl2] (L-n = L-A-L-D) supported with N,N'-bidentate aminomethylquinoline and aminomethylpyridine derived ligands, such as 2-(piperidin-1-ylmethyl)quinoline (L-A), 4-(quinolin-2-ylmethyl) morpholine (L-B), 2-(piperidin-1-ylmethyl)pyridine (L-C), and 4-(pyridin-2-ylmethyl)morpholine (L-D), were synthesized and structurally characterized. The structural data revealed that distorted tetrahedral geometries are adopted by Zn(II) metal ions by coordinating with corresponding ligands in a bidentate fashion. Catalytic studies conducted with these complexes in the presence of initiating reagents, i.e., LiMe, LiOCHMe2, and LiCl, showed that they can initiate ring-opening polymerization (ROP) of rac-lactide (rac-LA). All the tested initiators were active, with the in situ catalytic systems of [LnZnCl(2)] and [LiMe] displaying marked differences in the initiation, polymerization rate and control toward ROP of rac-LA compared to the in situ catalytic systems of [LnZnCl(2)] and [(LiOPr)-Pr-i], giving an 87% conversion of rac-LA within 30 sec using [rac-LA]:[LBZ(n)Cl(2)]:[LiMe] = 100:1:2 at 0 degrees C. Polylactides (PLAs) obtained were of low molecular weights with slightly higher polydispersity indices (PDI = 1.21-1.25) in all cases regardless of the initiating Zn(II) system and variations in ancillary ligands. Overall, the higher hetero-enriched PLAs were provided by the in situ catalytic systems of [LnZnCl2] and [LiMe] (the highest P-r up to 0.86 at 0 degrees C) compared to that with the in situ system of [LnZ(n)Cl(2)] and [(LiOPr)-Pr-i]. | Lee, Jaegyeong; Kim, Dongil; Lee, Hyosun; Nayab, Saira; Han, Ji Hoon | Kyungpook Natl Univ, Dept Chem & Green Nano Mat Res Ctr, Daehakro 80, Daegu 41566, South Korea; Shaheed Benazir Bhutto Univ, Dept Chem, Sheringal Dir U 18000, Khyber Pakhtunk, Pakistan; Andong Natl Univ, Dept Appl Chem, 1375 Gyeongdong Ro, Andong 36729, Gyeongbuk, South Korea | Nayab, Saira/JBS-3013-2023 | 57202254509; 35474978000; 15750846000; 36490286400; 57439639400 | hyosunlee@knu.ac.kr;drnayab@sbbu.edu.pk; | POLYHEDRON | POLYHEDRON | 0277-5387 | 1873-3719 | 216 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR;CRYSTALLOGRAPHY | 2022 | 2.6 | 36.5 | 0.69 | 2025-06-25 | 7 | 7 | Aminomethylquinoline; Aminomethylpyridine; Zn(II) complexes; Tetrahedral geometry; Ring-opening polymerization; Hetero-enriched poly(lactide) | METAL-COMPLEXES; METHYL-METHACRYLATE; ALKOXIDE COMPLEXES; POLY(LACTIC ACID); ZN(II) COMPLEXES; STRUCTURAL-CHARACTERIZATION; EPSILON-CAPROLACTONE; CU(II); ROP; POLYLACTIDE | Aminomethylpyridine; Aminomethylquinoline; Hetero-enriched poly(lactide); Ring-opening polymerization; Tetrahedral geometry; Zn(II) complexes | Ligands; Lithium compounds; Metal ions; Polydispersity; Ring opening polymerization; Synthesis (chemical); Zinc compounds; Aminomethylpyridine; Aminomethylquinoline; Catalytic system; Hetero-enriched poly(lactide); Poly lactide; Rac-lactide; Ring-opening polymerization; Tetrahedral geometry; Zn complex; Zn(initiating zn) complex; Lime | English | 2022 | 2022-04-01 | 10.1016/j.poly.2022.115696 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Epidemiology and Clinical Characteristics of Human Coronaviruses-Associated Infections in Children: A Multi-Center Study | BackgroundHuman coronaviruses (HCoVs) are associated with upper respiratory tract infections. Although studies have analyzed the clinical and epidemiological characteristics of HCoV-associated infections, no multi-center studies have been conducted in Korean children. We aimed to describe the epidemiology and clinical characteristics of HCoV-associated infection in children. MethodsWe retrospectively reviewed medical records of children in whom HCoVs were detected using multiplex reverse transcriptase-polymerase chain reaction amplification in five centers from January 2015 to December 2019. ResultsOverall, 1,096 patients were enrolled. Among them, 654 (59.7%) patients were male. The median age was 1 year [interquartile range (IQR), 0-2 years]. HCoVs were identified mainly in winter (55.9%). HCoV-229E, HCoV-OC43, and HCoOV-NL63 were detected mainly in winter (70.9, 55.8, and 57.4%, respectively), but HCoV-HKU1 was mainly identified in spring (69.7%). HCoV-OC43 (66.0%) was detected most frequently, followed by HCoV-NL63 (33.3%), and HCoV-229E (7.7%). Two different types of HCoVs were co-detected in 18 samples, namely. Alphacoronavirus-betacoronavirus co-infection (n = 13) and, alphacoronavirus-alphacoronavirus co-infection (n = 5). No betacoronavirus-betacoronavirus co-infection was detected. Patients were diagnosed with upper respiratory tract infection (41.4%), pneumonia (16.6%), acute bronchiolitis (15.5%), non-specific febrile illness (13.1%), croup (7.3%), and acute gastroenteritis (5.1%). There were 832 (75.9%) hospitalized patients with a median duration of hospitalization of 4 days (IQR, 3-5 days); 108 (9.9%) patients needed supplemental oxygen with 37 (3.4%) needing high-flow nasal cannula or mechanical ventilation. There were no deaths. ConclusionHCoV-associated infections exhibit marked seasonality with peaks in winter. Patients with lower respiratory tract infection, a history of prematurity, or underlying chronic diseases may progress to a severe course and may need oxygen therapy. | Jo, Kyo Jin; Choi, Soo-Han; Oh, Chi Eun; Kim, HyeonA; Choi, Bong Seok; Jo, Dae Sun; Park, Su Eun | Pusan Natl Univ, Dept Pediat, Childrens Hosp, Yangsan, South Korea; Pusan Natl Univ Hosp, Dept Pediat, Busan, South Korea; Kosin Univ, Dept Pediat, Coll Med, Busan, South Korea; Kyungpook Natl Univ, Dept Pediat, Sch Med, Daegu, South Korea; Jeonbuk Natl Univ, Dept Pediat, Med Sch, Jeonju, South Korea | Park, SuEun/KHV-9023-2024; Jo, Dae Sun/I-5756-2014; Jo, Dae/S-2762-2019; OH, CHI EUN/GLQ-7050-2022 | 57210702300; 55841482200; 36461469400; 57416123700; 56547873100; 57556166600; 36465325900 | psepse@naver.com; | FRONTIERS IN PEDIATRICS | FRONT PEDIATR | 2296-2360 | 10 | SCIE | PEDIATRICS | 2022 | 2.6 | 36.5 | 2 | 2025-06-25 | 8 | 10 | human coronavirus; multiplex polymerase chain reaction; children; multi-center study; prognosis | HOSPITALIZED CHILDREN; RESPIRATORY-DISEASE; HKU1; NL63; COMMUNITY | children; human coronavirus; multi-center study; multiplex polymerase chain reaction; prognosis | acute gastroenteritis; Article; artificial ventilation; bronchiolitis; child; clinical feature; coinfection; controlled study; Coronaviridae infection; disease severity; female; fever; high flow nasal cannula therapy; hospital admission; hospital patient; hospitalization; human; Human coronavirus 229E; Human coronavirus HKU1; Human coronavirus NL63; Human coronavirus OC43; infection rate; length of stay; major clinical study; male; medical record review; morbidity; multiplex reverse transcription polymerase chain reaction; nasopharyngeal swab; oxygen supply; oxygen therapy; pneumonia; preschool child; retrospective study; South Korea; spring; upper respiratory tract infection; virus detection; winter | English | 2022 | 2022-04-12 | 10.3389/fped.2022.877759 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Incidence and Prevalence Trends of Pediatric Inflammatory Bowel Disease in the Daegu-Kyungpook Province From 2017 to 2020 | Background and Aim: There is paucity of data regarding the epidemiology of pediatric IBD in Asia compared to that of Western countries. We aimed to investigate the incidence and prevalence trends of pediatric inflammatory bowel disease (IBD) in the Daegu-Kyungpook province of South Korea from 2017 to 2020.Methods: This study was a multicenter, retrospective study conducted in eight IBD referral centers located in the Daegu-Kyungpook province. Children and adolescents of <= 18 years who were initially diagnosed with IBD between 2017 and 2020 were included. The annual number of children and adolescents newly diagnosed with IBD and the annual resident population of children and adolescents <= 18 years of age in the Daegu-Kyungpook province were investigated to calculate the annual incidence and prevalence in the region.Results: A total 304 children and adolescents that had been diagnosed with IBD were included in this study. Among these patients, 71.4% had been diagnosed with Crohn's disease (CD), and 28.6% with ulcerative colitis (UC). The population based annual incidences of IBD from 2017 to 2020 were each 7.24, 6.82, 10.27, and 13.33 per 100,000, respectively (P for trend <0.001), 4.48, 5.26, 7.39, and 9.8 per 100,000, respectively, for CD (P for trend <0.001), and 2.76, 1.56, 2.88, and 3.53 per 100,000, respectively, for UC (P for trend = 0.174).Conclusion: Pediatric IBD, especially CD has significantly increased recently in the Daegu-Kyungpook province. Epidemiology studies from other regions of Asia are required to better elucidate this trend of increase in Asia. | Choe, Jae Young; Choi, Sujin; Song, Ki Hwan; Jang, Hyo-Jeong; Choi, Kwang-Hae; Yi, Dae Yong; Hong, Suk Jin; Hwang, Jun Hyun; Cho, Seung-Man; Kim, Young Jin; Choe, Byung-Ho; Kang, Ben | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Daegu, South Korea; Goo Hosp, Dept Surg, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Pediat, Daegu, South Korea; Yeungnam Univ, Dept Pediat, Sch Med, Daegu, South Korea; Chung Ang Univ, Coll Med, Dept Pediat, Seoul, South Korea; Daegu Catholic Univ, Dept Pediat, Sch Med, Daegu, South Korea; Daegu Catholic Univ, Dept Prevent Med, Sch Med, Daegu, South Korea; Dongguk Univ, Dept Pediat, Sch Med, Gyeongju, South Korea; Daegu Fatima Hosp, Dept Pediat, Daegu, South Korea | Choe, Byung-Ho/KSM-6251-2024; 康, 奔/JMQ-0812-2023; Yi, Dae/G-1729-2014 | 57023107400; 57223972405; 56404948200; 55355948500; 55040976900; 57190851975; 56573097000; 36129337200; 35168810700; 57221868564; 57574977300; 57194823199 | benkang@knu.ac.kr; | FRONTIERS IN PEDIATRICS | FRONT PEDIATR | 2296-2360 | 9 | SCIE | PEDIATRICS | 2022 | 2.6 | 36.5 | 3.8 | 2025-06-25 | 17 | 19 | COVID-19; inflammatory bowel disease; Crohn's disease; Korea; Asia; child | ULCERATIVE-COLITIS; NATURAL-HISTORY; POPULATION; EPIDEMIOLOGY; CHILDREN; CANADA; COHORT; YOUNG | Asia; child; COVID-19; Crohn's disease; inflammatory bowel disease; Korea | adolescent; age; Article; child; comparative study; coronavirus disease 2019; Crohn disease; female; human; incidence; inflammatory bowel disease; major clinical study; male; multicenter study; prevalence; retrospective study; South Korea; ulcerative colitis | English | 2022 | 2022-01-04 | 10.3389/fped.2021.810173 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Kawasaki disease following SARS-CoV-2 infection: Stronger inflammation with no increase in cardiac complications | BackgroundHerein we investigate the difference between Kawasaki disease (KD) with and without a recent history of SARS-CoV-2 infection. MethodsWe compared the clinical characteristics of patients with KD during the SARS-CoV-2 pandemic in a single children's hospital in Korea. Fifty-two patients were enrolled and divided into group 1 (with a history of COVID-19, n = 26) and group 2 (without a history of COVID-19, n = 26) according to whether or not they contracted COVID-19 within the 8 weeks before hospitalization. Data, including clinical features and laboratory results, were analyzed and compared between groups. ResultsThe median age of patients was significantly higher in group 1 than in group 2 (53 months [IQR, 24-81] vs. 15 months [IQR, 6-33], p = 0.001). The incidence of cervical lymphadenopathy was significantly higher (p = 0.017), while that of BCGitis was significantly lower in group 1 (p = 0.023), and patients had a significantly longer hospital stay (5 days [IQR, 3-8] vs. 3 days [IQR, 3-4], p = 0.008). In group 1, platelet count was significantly lower (p = 0.006), and hemoglobin and ferritin levels were significantly higher (p = 0.013 and p = 0.001, respectively) on the first admission day. Following treatment with intravenous immunoglobulin (IVIG), the platelet count was significantly lower (p = 0.015), and the percentage of neutrophils and neutrophil-to-lymphocyte ratio were significantly higher in group 1 (p = 0.037 and p = 0.012). Although there was no statistical difference, patients requiring infliximab treatment due to prolonged fever was only in group 1. The incidence of cardiovascular complications did not differ between the groups. ConclusionsPost-COVID KD showed a stronger inflammatory response than KD-alone, with no differences in cardiac complications. | Roh, Da Eun; Lim, Young Tae; Kwon, Jung Eun; Kim, Yeo Hyang | Inje Univ, Busan Paik Hosp, Coll Med, Dept Pediat, Busan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Childrens Hosp, Div Pediat Cardiol, Daegu, South Korea | 57195734230; 57197274340; 57194002366; 57032023800 | kimyhmd@knu.ac.kr; | FRONTIERS IN PEDIATRICS | FRONT PEDIATR | 2296-2360 | 10 | SCIE | PEDIATRICS | 2022 | 2.6 | 36.5 | 0.8 | 2025-06-25 | 4 | 4 | SARS-CoV-2; COVID-19; mucocutaneous lymph node syndrome; pediatric multisystem inflammatory disease; COVID-19 related; macrophage activation syndrome | CHILDREN; COVID-19; DIAGNOSIS; EPIDEMIOLOGY; MANAGEMENT | COVID-19; COVID-19 related; macrophage activation syndrome; mucocutaneous lymph node syndrome; pediatric multisystem inflammatory disease; SARS-CoV-2 | alanine aminotransferase; albumin; aspartate aminotransferase; bilirubin; C reactive protein; ferritin; fibrinogen; hemoglobin; hypertensive factor; immunoglobulin; infliximab; lactate dehydrogenase; methylprednisolone; procalcitonin; sodium; triacylglycerol; adult; age; aneurysm; Article; cardiovascular disease; cervical lymphadenopathy; clinical feature; comparative study; coronavirus disease 2019; demographics; echocardiography; edema; erythema; feet edema; female; fever; gastrointestinal symptom; hand edema; heart arrhythmia; heart muscle contractility; heart ventricle contractility; hemoglobin blood level; human; hypotension; incidence; length of stay; leukocyte; lymphocyte; major clinical study; male; mitral valve regurgitation; mucocutaneous lymph node syndrome; neutrophil; neutrophil lymphocyte ratio; neutrophil percentage; onset age; pandemic; pericardial effusion; platelet count; rash; real time reverse transcription polymerase chain reaction; retrospective study; sex ratio; South Korea; systolic dysfunction | English | 2022 | 2022-11-17 | 10.3389/fped.2022.1036306 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Translational Strategies to Eliminate Chronic Hepatitis B in Children: Prophylaxis and Management in East Asian Countries | Translational medical research on hepatitis B virus (HBV) infection and chronic hepatitis B (CHB) pathogenesis provides guidance on strengthening the treatment and prevention strategies of CHB. Preventing vertical transmission is the key to eliminating HBV infection in children. The understanding of HBV replication, hepatocyte turnover, and the fate of covalently closed circular DNA (cccDNA) would help establish a personalized application of the guidelines, especially concerning the discontinuation of nucleos(t)ide analog (NA) treatment in children. Transplacental leakage of HBV-infected maternal blood is suggested as the leading cause of vertical transmission. Prenatal maternal prophylaxis could diminish maternal HBV viremia at delivery, to reduce the risk of neonatal HBV infection. The meaning of the expression "no additional risk of breast milk feeding" is thereby explained. Understanding the untreated natural course of CHB in children and the course changeable by treatment is important to apply individualistic strategies and avoid the immoral selection of treatment indications. NAs with potent efficacy and a high barrier to drug resistance should be used as first-line treatment to reduce the likelihood of NA-resistant HBV development because the rate of mutant HBV emergence might count on the infected hepatocyte turnover rate in chronic HBV infection. Although elimination of intranuclear cccDNA is difficult by NAs alone, a cure is possible by human immunity and hepatocyte turnover. The reduction of intranuclear cccDNA occurs after the destruction of HBV-infected hepatocytes, non-cytolytic immune response, apoptosis of hepatocytes, and compensatory cell proliferation. Therefore, consolidation therapy after NA-induced hepatitis B e-antigen seroconversion must be necessary for a sufficient period. This review also summarizes the treatment strategies of CHB in children based on the practical application of translational research. | Kang, Ben; Yi, Dae Yong; Choe, Byung-Ho | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Dept Pediat, Coll Med, Seoul, South Korea | Choe, Byung-Ho/KSM-6251-2024; Yi, Dae/G-1729-2014; 康, 奔/JMQ-0812-2023 | 57194823199; 57190851975; 57574977300 | bhchoi@knu.ac.kr; | FRONTIERS IN PEDIATRICS | FRONT PEDIATR | 2296-2360 | 9 | SCIE | PEDIATRICS | 2022 | 2.6 | 36.5 | 0.39 | 2025-06-25 | 5 | 4 | viral replication; hepatocytes; turnover; cccDNA; hepatitis B virus; nucleos(t)ide analog | CLOSED CIRCULAR DNA; VIRUS-INFECTION; HEPATOCELLULAR-CARCINOMA; VERTICAL TRANSMISSION; HBEAG SEROCONVERSION; SPECIAL EMPHASIS; E-ANTIGEN; HBSAG; HEPATOCYTES; CLEARANCE | cccDNA; hepatitis B virus; hepatocytes; nucleos(t)ide analog; turnover; viral replication | antivirus agent; circular DNA; hepatitis B(e) antigen; antiviral therapy; cell proliferation; chronic hepatitis B; disease elimination; Hepatitis B virus; human; liver cell; nonhuman; Review; seroconversion; translational research; treatment indication; turnover rate; vertical transmission; viral clearance; virus replication | English | 2022 | 2022-02-04 | 10.3389/fped.2021.809838 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2019 | Purpose The current study provides national cancer statistics and their secular trends in Korea, including incidence, mortality, survival, and prevalence in 2019. Materials and Methods Incidence, survival, and prevalence rates of cancer were calculated using the Korea National Cancer Incidence Database, from 1999 to 2019, with survival follow-up until December 31, 2020. Deaths from cancer were assessed using causes-of-death data obtained from Statistics Korea. Results In 2019, newly diagnosed cancer cases and deaths from cancer were reported as 254,718 (age-standardized rate [ASR], 275.4 per 100,000) and 81,203 (ASR, 72.2 per 100,000), respectively. For the first time, lung cancer (n=29,960) became the most frequent cancer in Korea, excluding thyroid cancer. The overall cancer incidence rates increased by 3.3% annually from 1999 to 2012, and decreased by 5.3% annually from 2012 to 2015, thereafter, followed by nonsignificant changes. The incidence of thyroid cancer increased again from 2016 (annual percentage change, 6.2%). Cancer mortality rates have been decreasing since 2002, with more rapid decline in recent years (annual decrease of 2.7% from 2002 to 2013; 3.3% from 2013 to 2019). The 5-year relative survival between 2015 and 2019 was 70.7%, which contributed to prevalent cases reaching over 2 million in 2019. Conclusion Cancer survival rates have improved over the past decades, but the number of newly diagnosed cancers is still increasing, with some cancers showing only marginal improvement in survival outcomes. As the number of cancer survivors increases, a comprehensive cancer control strategy should be implemented in line with the changing aspects of cancer statistics. © 2022 Korean Cancer Association. All rights reserved. | Kang, Mee Joo; Won, Young-Joo; Lee, Jae Jun; Jung, Kyu-Won; Kim, Hye-Jin; Kong, Hyun-Joo; Im, Jeong-Soo; Seo, Hong Gwan; Kim, Chang-Hoon; Yoo, Cheol-In; Kim, Yong-Dae; Kim, Young-Taek; Park, Chul Min; Youm, Jung-Ho; Lim, Kyuhyoung; Hong, Nam-Soo; Kweon, Sun-Seog; Kim, Woo-Chul; Park, Ki-Soo | Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea, National Cancer Center Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, Division of Cancer Registration and Surveillance, National Cancer Control Institute, National Cancer Center, Goyang, South Korea; National Cancer Control Institute, National Cancer Center, Goyang, South Korea; Korea Central Cancer Registry, National Cancer Center, Goyang, South Korea, National Cancer Center Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea; Busan Cancer Registry, Pusan National University Hospital, South Korea; Ulsan Cancer Registry, Ulsan University Hospital, South Korea; Chungbuk Cancer Registry, Chungbuk National University Hospital, South Korea; Daejeon/Chungnam Cancer Registry, Chungnam National University and Hospital, South Korea; Jeju Cancer Registry, Jeju National University and Hospital, South Korea; Chonbuk Cancer Registry, Jeonbuk National University Hospital, South Korea; Kangwon Cancer Registry, Kangwon National University Hospital, South Korea; Daegu/Gyeongbuk Cancer Registry, Kyungpook National University Medical Center, South Korea; Gwangju/Jeonnam Cancer Registry, Chonnam National University Hwasun Hospital, South Korea; Incheon Cancer Registry, Inha University Hospital, South Korea; Gyeongnam Cancer Registry, Gyeongsang National University and Hospital, South Korea | 23018377700; 7102129118; 57221933938; 7402479862; 57194054637; 57202469400; 14621582000; 57199873685; 57203626040; 7201746392; 8277138500; 57211411051; 57200324105; 58406928700; 24177182600; 54684167600; 7003824608; 55730056400; 56014252100 | astra67@ncc.re.kr; | Cancer Research and Treatment | CANCER RES TREAT | 1598-2998 | 2005-9256 | 54 | 2 | SCIE | ONCOLOGY | 2022 | 4.6 | 36.7 | 22.03 | 2025-06-25 | 233 | Incidence; Korea; Mortality; Neoplasms; Prevalence; Survival | adolescent; adult; age; age distribution; aged; Article; bladder cancer; brain cancer; breast cancer; cancer epidemiology; cancer incidence; cancer mortality; cancer prognosis; cancer statistics; cancer survival; carcinoma in situ; cause of death; central nervous system cancer; cerebrovascular disease; child; childhood cancer; chronic respiratory tract disease; colorectal cancer; data base; diabetes mellitus; esophagus cancer; female; follow up; gallbladder cancer; heart disease; hepatobiliary system cancer; Hodgkin disease; human; hypertension; ICD-O-3; infant; kidney cancer; Korea; larynx cancer; leukemia; lip cancer; liver cancer; liver disease; lung cancer; major clinical study; male; malignant neoplasm; mortality rate; mouth cancer; multiple cancer; multiple myeloma; newborn; nonhodgkin lymphoma; ovary cancer; pancreas cancer; pharynx cancer; pneumonia; prevalence; prostate cancer; sex difference; standardized incidence ratio; standardized mortality ratio; stomach cancer; suicide; survival rate; testis cancer; thyroid cancer; traffic accident; trend study; uterine cervix cancer; uterus cancer; young adult | English | Final | 2022 | 10.4143/crt.2022.128 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group | Purpose Acute promyelocytic leukemia (APL) is a rare disease in children and there are some different characteristics between children and adult. We aimed to evaluate incidence, clinical characteristics and treatment outcomes of pediatric APL in Korea. Materials and Methods Seventy-nine pediatric APL patients diagnosed from January 2009 to December 2016 in 16 tertiary medical centers in Korea were reviewed retrospectively. Results Of 801 acute myeloid leukemia children, 79 (9.9%) were diagnosed with APL. The median age at diagnosis was 10.6 years (range, 1.3 to 18.0). Male and female ratio was 1:0.93. Thirty patients (38.0%) had white blood cell (WBC) count greater than 10x10(9)/L at diagnosis. All patients received induction therapy consisting of all-trans retinoic acid and chemotherapy. Five patients (6.6%) died during induction chemotherapy and 66 patients (86.8%) achieved complete remission (CR) after induction chemotherapy. The causes of death were three intracranial hemorrhage, one cerebral infarction, and one sepsis. Five patients (7.1%) suffered a relapse during or after maintenance chemotherapy. The estimated 4-year event-free survival and overall survival (OS) rates were 82.1%+/- 4.4%, 89.7%+/- 5.1%, respectively. The 4-year OS was significantly higher in patients with initial WBC = 10x10(9)/L (p=0.020). Conclusion This study showed that the CR rates and survival outcomes in Korean pediatric APL patients were relatively good. The initial WBC count was the most important prognostic factor and most causes of death were related to serious bleeding in the early stage of treatment. | Park, Kyung Mi; Yoo, Keon Hee; Kim, Seong Koo; Lee, Jae Wook; Chung, Nack-Gyun; Ju, Hee Young; Koo, Hong Hoe; Lyu, Chuhl Joo; Han, Seung Min; Han, Jung Woo; Choi, Jung Yoon; Hong, Kyung Taek; Kang, Hyoung Jin; Shin, Hee Young; Im, Ho Joon; Koh, Kyung-Nam; Kim, Hyery; Kook, Hoon; Baek, Hee Jo; Kim, Bo Ram; Yang, Eu Jeen; Lim, Jae Young; Park, Eun Sil; Choi, Eun Jin; Park, Sang Kyu; Lee, Jae Min; Shim, Ye Jee; Kim, Ji Yoon; Park, Ji Kyoung; Kong, Seom Gim; Choi, Young Bae; Cho, Bin; Lim, Young Tak | Dongnam Inst Radiol & Med Sci, Dept Pediat, Busan, South Korea; Sungkyunkwan Univ, Dept Pediat, Samsung Med Ctr, Sch Med, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Pediat, Coll Med, 222 Banpo Daero, Seoul 06591, South Korea; Yonsei Univ, Dept Pediat, Coll Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Pediat, Inst Canc, Seoul, South Korea; Univ Ulsan, Coll Med, Div Pediat Hematol & Oncol, Dept Pediat,Asan Med Ctr,Childrens Hosp, Seoul, South Korea; Chonnam Natl Univ, Sch Med, Dept Pediat, Hwasun Hosp, Gwangju, South Korea; Pusan Natl Univ, Sch Med, Dept Pediat, Yangsan, South Korea; Gyeongsang Natl Univ, Coll Med, Dept Pediat, Jinju, South Korea; Daegu Catholic Univ, Sch Med, Dept Pediat, Daegu, South Korea; Univ Ulsan, Sch Med, Dept Pediat, Ulsan, South Korea; Yeungnam Univ, Coll Med, Dept Pediat, Daegu, South Korea; Keimyung Univ, Coll Med, Dept Pediat, Dongsan Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Inje Univ, Coll Med, Busan Paik Hosp, Dept Pediat, Busan, South Korea; Kosin Univ Med, Dept Pediat, Busan, South Korea; Ajou Univ, Sch Med, Dept Pediat, Suwon, South Korea | Han, Jung Woo/ABI-6899-2022; Hahn, Seung min/MBH-8374-2025; Lee, Jaewoong/IQS-0514-2023; Lee, Jae Min/H-8475-2013; Park, Jung Hoon/CZZ-0090-2022; Choi, Jungyoon/AAA-3883-2021; KIM, SUNG/ADF-8559-2022; Chung, Chun/J-5650-2012; Koh, Kyung-Nam/AAA-2747-2022; Kim, Tae/B-9921-2013 | 59618416000; 35304229600; 55486370800; 57218595050; 24074375300; 56389223700; 7102120540; 7004643628; 57429335900; 56927055400; 57102078500; 55145561500; 7404071502; 56582799400; 14524798500; 36508814500; 57196215369; 7006255531; 36724802200; 59441976500; 56594276100; 55555512300; 26030635800; 35075812900; 57209835309; 39261799700; 57222517942; 57205408095; 35332704400; 36982973800; 57204085410; 57789898000; 7402565128 | chobinkr@catholic.ac.kr;limyt@pusan.ac.kr; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 54 | 1 | SCIE | ONCOLOGY | 2022 | 4.6 | 36.7 | 0.47 | 2025-06-25 | 5 | 5 | Acute promyelocytic leukemia; All-trans retinoic acid; Childhood | TRANS-RETINOIC ACID; APL; CHILDREN; CONSOLIDATION; ADOLESCENTS; PETHEMA | Acute promyelocytic leukemia; All-trans retinoic acid; Childhood | Adolescent; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Disease-Free Survival; Female; Humans; Induction Chemotherapy; Infant; Leukemia, Promyelocytic, Acute; Leukocyte Count; Male; Progression-Free Survival; Remission Induction; Republic of Korea; Retrospective Studies; Treatment Outcome; Tretinoin; anthracycline; cytarabine; idarubicin; mercaptopurine; methotrexate; mitoxantrone; retinoic acid; antineoplastic agent; retinoic acid; adolescent; adult; Article; brain hemorrhage; brain infarction; cancer combination chemotherapy; cancer incidence; cancer recurrence; cause of death; child; childhood cancer; clinical feature; clinical outcome; comparative study; congestive heart failure; differentiation syndrome; event free survival; female; fever; headache; human; hypotension; induction chemotherapy; kidney failure; Korea; leukemia remission; leukocyte count; low drug dose; lung infiltrate; maintenance chemotherapy; major clinical study; male; overall survival; pericardial effusion; pleura effusion; promyelocytic leukemia; respiratory distress; retrospective study; sepsis; tertiary health care; treatment outcome; clinical trial; disease free survival; epidemiology; infant; mortality; multicenter study; preschool child; procedures; promyelocytic leukemia; remission; South Korea | English | 2022 | 2022-01 | 10.4143/crt.2021.313 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Evaluation of a Direct Reverse Transcription Loop-Mediated Isothermal Amplification Method without RNA Extraction (Direct RT-LAMP) for the Detection of Lymph Node Metastasis in Early Breast Cancer | Purpose Assessing lymph node metastasis, tumor-derived DNA, or tumor-derived RNA has previously been studied in place of immu- nohistochemical assay. Because a direct reverse transcription loop-mediated isothermal amplification method (direct RT-LAMP) has been previously developed in order to rapidly identify viruses in place of RNA extraction, our team hypothesized that a direct RT-LAMP assay can be employed as a substitute in order to detect tumor involvement of lymph nodes within breast cancer patients. Materials and Methods A total amount of 92 lymph nodes removed across 40 patients possessing breast cancer were collected at Kyungpook National University Chilgok Hospital between the months of November 2015 and February 2016. All samples were then evaluated and contrasted via both a direct RT-LAMP assay and routine histopathologic examination. Results The sensitivity and specificity of the direct RT-LAMP assay were 85.7% and 100%, respectively. The positive predictive value and negative predictive value were 100% and 94.4%, respectively. Conclusion Direct RT-LAMP assay is capable of facilitating the detection of sentinel lymph node metastasis within breast cancer patients intraoperatively possessing an excellent sensitivity via a cost-effective and time-saving manner. | Lee, In Hee; Jung, Jin Hyang; Lee, Soo Jung; Lee, Jeeyeon; Park, Ho Yong; Park, Ji-Young; Park, Jee Young; Jung, Jae-Hwan; Lee, Hyunchul; Jeon, Hyo-Sung; Chae, Yee Soo | Daegu Catholic Univ, Dept Internal Med, Div Hematol Oncol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Chilgok Hosp, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Chilgok Hosp, Dept Oncol Hematol, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Chilgok Hosp, Dept Pathol, Daegu, South Korea; M Monitor Inc, Daegu, South Korea; DNP Biotech Inc, Daegu, South Korea | Lee, Jong-Mok/KVY-9550-2024; Park, Joohyun/KAL-8175-2024; Park, Jun/HPH-3570-2023; Park, Jung Hwan/AAA-1951-2022; PARK, JUN-YOUNG/P-5981-2015 | 56390538200; 57209310173; 57203597252; 37079213100; 56564377200; 57210160197; 57226185359; 57429656900; 57429834700; 59108838200; 57190793908 | yschae@knu.ac.kr; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 54 | 1 | SCIE | ONCOLOGY | 2022 | 4.6 | 36.7 | 0.19 | 2025-06-25 | 2 | 2 | Breast neoplasms; Lymphatic metastasis; Reverse transcription loop-mediated isothermal amplification | NUCLEIC-ACID AMPLIFICATION; SENTINEL NODE; INTRAOPERATIVE DETECTION; BIOPSY | Breast neoplasms; Lymphatic metastasis; Reverse transcription loop-mediated isothermal amplification | Adult; Aged; Breast Neoplasms; Female; Humans; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Molecular Diagnostic Techniques; Nucleic Acid Amplification Techniques; Reverse Transcription; Sensitivity and Specificity; adult; aged; Article; breast cancer; cancer patient; clinical feature; controlled study; early cancer; evaluation study; female; histopathology; human; human tissue; lymph node metastasis; major clinical study; male; predictive value; reverse transcription loop mediated isothermal amplification; RNA extraction; sensitivity and specificity; breast tumor; lymph node; lymph node metastasis; middle aged; molecular diagnosis; nucleic acid amplification techniques; pathology; reverse transcription | English | 2022 | 2022-01 | 10.4143/crt.2020.749 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Postmastectomy Radiation Therapy for Node-Negative Breast Cancer of 5 cm or Larger Tumors: A Multicenter Retrospective Analysis (KROG 20-03) | Purpose This study aimed to evaluate the role of postmastectomy radiation therapy (PMRT) in patients with node-negative breast cancer of 5cm or larger tumors undergoing mastectomy. Materials and Methods Medical records of 274 patients from 18 institutions treated with mastectomy between January 2000 and December 2016 were retrospectively reviewed. Among these, 202 patients underwent PMRT, while 72 did not. Two hundred and forty-one patients (88.0%) received systemic chemotherapy, and 172 (62.8%) received hormonal therapy. Patients receiving PMRT were younger, more likely to have progesterone receptor-positive tumors, and received adjuvant chemotherapy more frequently compared with those without PMRT (p < 0.001, p=0.018, and p < 0.001, respectively). Other characteristics were not significantly different between the two groups. Results With a median follow-up of 95 months (range, 1 to 249 months), there were nine locoregional recurrences, and 20 distant metastases. The 8-year locoregonal recurrence-free survival rates were 98.0% with PMRT and 91.3% without PMRT (p=0.133), and the 8-year disease-free survival (DFS) rates were 91.8% with PMRT and 73.9% without PMRT (p=0.008). On multivariate analysis incorporating age, histologic grade, lymphovascular invasion, hormonal therapy, chemotherapy, and PMRT, the absence of lympho- vascular invasion and the receipt of PMRT were associated with improved DFS (p=0.025 and p=0.009, respectively). Conclusion Locoregional recurrence rate was very low in node-negative breast cancer of 5 cm or larger tumors treated with mastectomy regardless of the receipt of PMRT. However, PMRT was significantly associated with improved DFS. Further investigation is needed to confirm these findings. | Kim, Kyubo; Jung, Jinhong; Kim, Haeyoung; Jung, Wonguen; Shin, Kyung Hwan; Chang, Ji Hyun; Kim, Su Ssan; Park, Won; Chang, Jee Suk; Kim, Yong Bae; Ahn, Sung Ja; Lee, Ik Jae; Lee, Jong Hoon; Park, Hae Jin; Cha, Jihye; Kim, Juree; Choi, Jin Hwa; Koo, Taeryool; Kwon, Jeanny; Kim, Jin Hee; Kim, Mi Young; Park, Shin-Hyung; Kim, Yeon-Joo | Ewha Womans Univ, Dept Radiat Oncol, Coll Med, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Radiat Oncol, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Radiat Oncol, Sch Med, Seoul, South Korea; Seoul Natl Univ, Dept Radiat Oncol, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea; Yonsei Univ, Yonsei Canc Ctr, Dept Radiat Oncol, Coll Med, Seoul, South Korea; Chonnam Natl Univ, Dept Radiat Oncol, Med Sch, Gwangju, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Radiat Oncol, Coll Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Radiat Oncol, St Vincents Hosp, Suwon, South Korea; Hanyang Univ, Dept Radiat Oncol, Coll Med, Seoul, South Korea; Yonsei Univ Wonju, Dept Radiat Oncol, Coll Med, Wonju, South Korea; Cheil Gen Hosp, Dept Radiat Oncol, Seoul, South Korea; Womens Healthcare Ctr, Seoul, South Korea; Chung Ang Univ, Dept Radiol, Coll Med, Seoul, South Korea; Hallym Univ, Coll Med, Dept Radiat Oncol, Sacred Heart Hosp, Anyang, South Korea; Chungnam Natl Univ, Dept Radiat Oncol, Sch Med, Daejeon, South Korea; Keimyung Univ, Dept Radiat Oncol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Radiat Oncol, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Radiat Oncol, Daegu, South Korea; Natl Canc Ctr, Proton Therapy Ctr, Goyang, South Korea | KIM, JIN SU/U-2112-2019; Kim, Jae-Young/IUO-6466-2023; CHOI, JIN HWA/LWZ-8057-2024; Kim, Hye/AAF-7609-2020; Park, Shinhyung/LNQ-6428-2024; KIM, Yong/R-3111-2019; Chang, Jee Suk/ABU-3301-2022; Shin, Kwang-Hee/C-5687-2012; Kim, Haeyoung/ABC-4815-2020; lee, sang/Q-4650-2019 | radiat@snu.ac.kr; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 54 | 2 | SCIE | ONCOLOGY | 2022 | 4.6 | 36.7 | 5 | Breast neoplasms; >= 5 cm; Node-negative; Mastectomy; Radiotherapy | POSTOPERATIVE RADIOTHERAPY; LOCAL RECURRENCE; MASTECTOMY; WOMEN; IRRADIATION; SURVIVAL; OUTCOMES; SURGERY; T3N0 | English | 2022 | 2022-04 | 10.4143/crt2021.933 | 바로가기 | 바로가기 | 바로가기 |
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