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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Letter | Clinical Outcome of Breast Cancer Patients on Chemotherapy during the COVID-19 Pandemic in South Korea | Lee, S. J.; Kim, J.; Chae, Y. S. | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Oncol Hematol, Daegu, South Korea | Lee, Joong/A-5417-2013 | 57203597252; 55915816900; 57190793908 | CLINICAL ONCOLOGY | CLIN ONCOL-UK | 0936-6555 | 1433-2981 | 33 | 1 | SCIE | ONCOLOGY | 2021 | 4.925 | 38.6 | 0.38 | 2025-07-30 | 1 | 1 | breast cancer; cancer chemotherapy; clinical outcome; coronavirus disease 2019; disease course; human; infection risk; Letter; pandemic; patient education; personal hygiene; priority journal; South Korea | English | 2021 | 2021-01 | 10.1016/j.clon.2020.07.018 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | Article | Mechanical and clinical evaluation of the effect of microscrew on root proximity and cortical bone thickness | Background/Objectives: Primary stability is required for successful use of microscrew. This study investigated correlations among biomechanical, morphological, and clinical values in relationship to root contact and different placement locations. Materials/Methods: Thirty-three microscrews were placed between the molars (n = 18) or in the body of the mandible (n = 15) in three pigs. Insertion torque, Periotest, resonance frequency analysis (RFA), and static and dynamic stiffness were measured. Cone beam computed tomography was performed before and after the insertion of microscrews. Interproximal microscrews were divided into root contacted microscrews (n = 9) and non-root contact microscrews (n = 9). Factorial analysis of variance was conducted, with significance set at P < 0.05. Results: A significant difference was observed between bodily and root contacted microscrews in Periotest, RFA, static and dynamic stiffness, Tanδ, and bone density (RFA, P = 0.045; all others, P < 0.001). A significant difference was observed between bodily and non-root contact microscrews in Periotest, RFA, and bone density (RFA, P = 0.025; all others, P < 0.001). A significant difference was observed in static (P = 0.01) and dynamic (P = 0.038) stiffness between microscrews with and without contact. Dynamic stiffness (P = 0.02) and Tanδ (P = 0.03) showed significant correlations with Periotest results only in bodily microscrews. Limitations: Since a pig bone was used, some differences in the quality and quantity of the bone might be observed between humans. Conclusions/Implications: Stiffness values distinguished between microscrews with and without contact. Periotest and RFA results indicated that bodily microscrews were more stable than interproximal microscrews. Periotest and RFA may be useful with large, microscrews and/or in thick cortical bone, but further investigation is required to determine the stability of interproximal microscrews. © The Author(s) 2019. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved | Tsatalis, Andrea E.; Watanabe, Keiichiro; Mitchell, Bobby; Kim, Do-Gyoon; Lee, Damian J.; Zheng, Fengyuan; Kyung, Hee-Moon; Deguchi, Toru | College of Dentistry, Ohio State University, Columbus, United States; Division of Orthodontics, College of Dentistry, Ohio State University, Columbus, United States; Ohio State University, Columbus, United States; Division of Orthodontics, College of Dentistry, Ohio State University, Columbus, United States; Division of Restorative Sciences and Prosthodontics, College of Dentistry, Ohio State University Columbus, Columbus, United States; Division of Restorative Sciences and Prosthodontics, College of Dentistry, Ohio State University Columbus, Columbus, United States; Department of Orthodontics, School of Dentistry, Kyungpook National University, Daegu, South Korea; Division of Orthodontics, College of Dentistry, Ohio State University, Columbus, United States | 57192906317; 56044920500; 57216188104; 8635777000; 35095378900; 57208885403; 7004292284; 7201724448 | deguchi.4@osu.edu; | European Journal of Orthodontics | EUR J ORTHODONT | 0141-5387 | 1460-2210 | 42 | 2 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2021 | 3.131 | 38.6 | 1.17 | 2025-07-30 | 6 | Animals; Bone Density; Cortical Bone; Dental Implantation, Endosseous; Dental Implants; Humans; Mandible; Osseointegration; Swine; Torque; animal; bone density; cortical bone; diagnostic imaging; human; mandible; osseointegration; pig; surgery; tooth implant; tooth implantation; torque | English | Final | 2021 | 10.1093/ejo/cjz017 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Mid-term electricity load prediction using CNN and Bi-LSTM | Electricity is one of the critical role players to build an economy. Electricity consumption and generation can affect the overall policy of the country. Such importance opens an area for intelligent systems that can provide future insights. Intelligent management for electric power consumption requires future electricity power consumption prediction with less error. These predictions provide insights for making decisions to smooth line the policy and grow the country's economy. Future prediction can be categorized into three categories, namely (1) Long-Term, (2) Short-Term, and (3) Mid-Term predictions. For our study, we consider the Mid-Term electricity consumption prediction. Dataset provided by Korea Electric power supply to get insights for a metropolitan city like Seoul. Dataset is in time-series, so statistical and machine learning models can be used. This study provides experimental results from the proposed ARIMA and CNN-Bi-LSTM. Hyperparameters are tuned for ARIMA and neural network models to increase the models' accuracy, which looks promising as RMSE for training is 0.14 and 0.20 RMSE for testing. | Gul, M. Junaid; Urfa, Gul Malik; Paul, Anand; Moon, Jihoon; Rho, Seungmin; Hwang, Eenjun | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu, South Korea; Korea Univ, Sch Elect Engn, Seoul, South Korea; Sejong Univ, Seoul, South Korea | Gul, Malik junaid jami/O-1392-2018; Rho, Seungmin/HTP-6683-2023; Gul, Malik/O-1392-2018; Paul, Anand/V-6724-2017; Moon, Jihoon/ABB-6112-2021; gul, Malik Urfa/ISU-2871-2023 | 57203752948; 58087464900; 56650522400; 57193756583; 10738984000; 7101826788 | junaidgul@live.com.pk;theurfagul@gmail.com;paul.editor@gmail.com;johnny89@korea.ac.kr;smrho@sejong.ac.kr;ehwang04@korea.ac.kr; | JOURNAL OF SUPERCOMPUTING | J SUPERCOMPUT | 0920-8542 | 1573-0484 | 77 | 10 | SCIE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;COMPUTER SCIENCE, THEORY & METHODS;ENGINEERING, ELECTRICAL & ELECTRONIC | 2021 | 2.557 | 38.6 | 2.61 | 2025-07-30 | 37 | 47 | Mid-term power consumption; ARIMA; Neural network; CNN; BI-LSTM | ARIMA; BI-LSTM; CNN; Mid-term power consumption; Neural network | Autoregressive moving average model; Bismuth compounds; Electric power systems; Electric power utilization; Electric utilities; Forecasting; Intelligent systems; Electric power consumption; Electric power supply; Electricity-consumption; Future predictions; Intelligent management; Machine learning models; Metropolitan cities; Neural network model; Long short-term memory | English | 2021 | 2021-10 | 10.1007/s11227-021-03686-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Tumor immune microenvironment of primary colorectal adenocarcinomas metastasizing to the liver or lungs | Background Because of the heterogeneity of metastatic colorectal cancer (mCRC), a genome-wide analysis was performed to characterize the tumor immune microenvironment (TIME). Methods RNA-seq analysis of 62 primary CRCs without and 63 with systemic metastasis (SM- and SM+ groups) was conducted, and the data were used in a training set after adjustment by propensity score matching. Samples were further subdivided into those with hepatic metastasis (CHM subgroup), pulmonary metastasis (CPM subgroup), or concurrent CHM and CPM (concurrent group). Validation was done by quantitative reverse-transcription polymerase chain reaction using another 40 primary CRC samples. Results Compared with the CHM or CPM subgroups, the concurrent group showed upregulated in inflammatory or immune processes, cytokine secretion, and myeloid leukocyte migration. Nine candidate genes were selected: SM-specific IDO1, JAM3, and PDE2A; CHM- or CPM-specific BIRC7; CPM-specific HISI1H2BK, and both SM-specific and CHM- or CPM-specific EPHB6, LPL, THBD, and PPBP. In a validation set of primary CRCs, JAM3 and IDO1 (p = 0.044 and p = 0.036, respectively) were confirmed to show significant upregulation and downregulation, respectively, in the SM+ group, whereas HIST1H2BK (p = 0.017) was significantly upregulated in the CPM subgroup. Conclusions Our findings indicate that a host-suppressive TIME is established in the primary tumor of mCRC and identify immune-related site-specific markers of mCRC. | Kim, Jin C.; Ha, Ye J.; Park, In J.; Kim, Chan W.; Yoon, Yong S.; Lee, Jong L.; Tak, Ka H.; Cho, Dong-Hyung; Park, Seong H.; Kim, Seon-Kyu; Kim, Seon-Young; Kim, Yong S. | Univ Ulsan, Dept Surg, Coll Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Asan Med Ctr, Seoul, South Korea; Asan Med Ctr, Asan Inst Life Sci, Lab Canc Biol & Genet, Seoul, South Korea; Kyungpook Natl Univ, Sch Life Sci, Grad Sch, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol, Genome Editing Res Ctr, Daejeon, South Korea | Choi, Hye Rin/JDV-9065-2023; Lww, Jong/W-1791-2019; Kim, Seon-Kyu/KBA-0395-2024; Park, In/U-2371-2019; Kim, Seon-Young/A-7193-2009; Bin Kim, Hong/J-5452-2012 | 55664401800; 38561431400; 7403243464; 55966571500; 8423860200; 55194819000; 55363346300; 35093684400; 37025059300; 13410554000; 55146733100; 56570975100 | jckim@amc.seoul.kr; | JOURNAL OF SURGICAL ONCOLOGY | J SURG ONCOL | 0022-4790 | 1096-9098 | 124 | 7 | SCIE | ONCOLOGY;SURGERY | 2021 | 2.885 | 38.7 | 0.7 | 2025-07-30 | 6 | 6 | colorectal adenocarcinoma; immune; metastasis; microenvironment; RNA-seq | CANCER; GUIDELINES; ADHESION; COLON; CELLS | colorectal adenocarcinoma; immune; metastasis; microenvironment; RNA-seq | Adenocarcinoma; Case-Control Studies; Cell Adhesion Molecules; Colorectal Neoplasms; Down-Regulation; Female; Genome-Wide Association Study; Histones; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; RNA, Messenger; Tumor Microenvironment; Up-Regulation; amino acid; antineoplastic agent; carcinoembryonic antigen; complementary DNA; cyclic nucleotide phosphodiesterase 2; ephrin receptor B6; glyceraldehyde 3 phosphate dehydrogenase; hisi1h2bk protein; ido1 protein; junctional adhesion molecule C; lipoprotein lipase; livin; lpl protein; messenger RNA; pde2a protein; phosphatidylinositol 3 kinase; ppbp protein; protein kinase B; RNA; RNA directed DNA polymerase; thbd protein; unclassified drug; cell adhesion molecule; histone; histone H2B type 1-A; IDO1 protein, human; indoleamine 2,3 dioxygenase; JAM3 protein, human; messenger RNA; adult; Article; cell migration; clinical feature; colorectal carcinoma; colorectal liver metastasis; comparative study; controlled study; cytokine release; down regulation; female; genome-wide association study; human; immune response; liver metastasis; lung metastasis; major clinical study; male; middle aged; myeloid leukocyte; propensity score; quantitative analysis; reverse transcription polymerase chain reaction; RNA extraction; RNA sequencing; tumor microenvironment; upregulation; adenocarcinoma; case control study; colorectal tumor; genetics; liver tumor; lung tumor; metabolism; pathology; tumor microenvironment | English | 2021 | 2021-12 | 10.1002/jso.26631 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Noncovalent Functionalized Graphene Nanocarriers from Graphite for Treating Thyroid Cancer Cells | Here, biocompatible graphene (G) nanocarriers decorated with iron oxide nanoparticles (IONPs) were prepared using 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) and poly(ethylene glycol) monomethacrylate (PEGMA). For this, we report the use of graphite directly instead of graphene oxide or reduced graphene oxide. Graphene nanocarrier (in situ GIOPMPC) was prepared in one-pot by in situ copolymerization of MPC and PEGMA monomers in the presence of IONPs and G. GIOPMCP nanocarriers were prepared by sonication using PMPC-co-PEGMA copolymers in the presence of IONPs and G. The prepared graphene nanocarriers were thoroughly characterized by various techniques. The analyses confirmed the successful preparation of nanocarriers with even distributions of PMPC-co-PEGMA and IONPs on surface G. The IONPs were coordinated through the phosphate groups in PMPC. Excellent dispersibility of the graphene nanocarriers in water enabled drug delivery applications. The prepared nanocarriers did not show significant cytotoxicity to the thyroid cancer cells up to 8 mg/mL (IC50: 38.26 mg/mL). Thyroid cancer cells were stably transduced with a bioluminescent reporter to monitor cell cytotoxicity. Doxorubicin (DOX) was loaded onto in situ GIOPMPC nanocarriers at two different concentrations and was successfully delivered to thyroid cancer cells, resulting in strong cytotoxicity. Moreover, signaling mechanistic analyses showed apoptosis activation, inhibition of anti-apoptosis and proliferation, and increased DNA damage in the thyroid cancer cells. | Perumal, Suguna; Gangadaran, Prakash; Bae, Ye Won; Ahn, Byeong-Cheol; Cheong, In Woo | Kyungpook Natl Univ, Sch Engn, Dept Appl Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 KNU Convergence Educ Program Biomed Sci Crea, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu 41944, South Korea | Gangadaran, Prakash/AAV-3102-2021; perumal, suguna/N-9075-2017 | 56673798900; 54393130400; 57201280756; 7202791511; 7006733373 | abc2000@knu.ac.kr;inwoo@knu.ac.kr; | ACS BIOMATERIALS SCIENCE & ENGINEERING | ACS BIOMATER SCI ENG | 2373-9878 | 7 | 6 | SCIE | MATERIALS SCIENCE, BIOMATERIALS | 2021 | 5.395 | 38.9 | 0.65 | 2025-07-30 | 13 | 12 | graphene; iron oxide nanoparticle; phosphorylcholine; in situ polymerization; thyroid cancer; doxorubicin | ENHANCED FIREFLY LUCIFERASE; DRUG-DELIVERY; BREAST-CANCER; SUBCELLULAR-LOCALIZATION; LUNG-CANCER; DOXORUBICIN; OXIDE; PROTEIN; VISUALIZATION; EXFOLIATION | doxorubicin; graphene; in situ polymerization; iron oxide nanoparticle; phosphorylcholine; thyroid cancer | Doxorubicin; Drug Carriers; Drug Delivery Systems; Graphite; Humans; Thyroid Neoplasms; Biocompatibility; Cell death; Cell signaling; Controlled drug delivery; Cytotoxicity; Diseases; Graphite; Iron oxides; Magnetic nanoparticles; Polyethylene glycols; Targeted drug delivery; 2 (methacryloxy)ethyl phosphorylcholine; copolymer; doxorubicin; graphene; graphene oxide; graphite; iron oxide nanoparticle; nanocarrier; phosphate; polyethylene glycol monomethacrylic acid; polymer; unclassified drug; water; doxorubicin; drug carrier; 2- ethyl phosphorylcholine (mpc)(Methacryloyloxy); Dispersibilities; Drug delivery applications; Functionalized graphene; Iron oxide nanoparticles (IONPs); Mechanistic analysis; Phosphate group; Situ copolymerization; antiapoptosis; antineoplastic activity; apoptosis; Article; biocompatibility; bioluminescence; CAL-62 cell line; cell proliferation; controlled study; cytotoxicity; dispersity; drug delivery system; drug effect; human; human cell; IC50; in vitro study; one pot synthesis; polymerization; signal transduction; thyroid cancer cell line; ultrasound; drug delivery system; thyroid tumor; Graphene | English | 2021 | 2021-06-14 | 10.1021/acsbiomaterials.1c00067 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Biological Factors Associated with Infectious Diarrhea in Calves | Calf diarrhea is a major cause of economic loss in the cattle industry. Identifying biomarkers associated with the pathological conditions may provide beneficial guidelines for detecting disease progression and monitoring effectiveness of therapeutic agents in calves suffering from diarrhea. The objective of this research was to find out biological factors associated with calf diarrhea, based on clinical findings and the presence of enteric pathogens. Fecal and blood samples were obtained from 73 non-diarrheal and 42 diarrheal calves. The presence of enteric pathogens, hemato-chemical parameters, acute phase proteins, and pro-inflammatory cytokines were investigated in the samples. According to the presence of diarrhea and pathogens, the calves were classified into healthy (n=35), subclinical (non-diarrheal but pathogen-positive, n=36), infectious diarrheal (diarrheal and pathogen-positive, n=39), and unknown diarrheal groups (diarrheal but pathogen-negative, n=3). The presence of bovine coronavirus, bovine rotavirus group A, and Cryptosporidium spp. were significantly associated with the development of calf diarrhea (P<0.05). The infectious diarrheal group showed increases in monocyte percentages and blood urea nitrogen level and the decreases in glucose, potassium, and phosphorus levels (P<0.05). Moreover, inflammatory proteins such as haptoglobin, fibrinogen, interleukin-6, and tumor necrosis factor-alpha were elevated in the infectious diarrheal group compared to the healthy group (P<0.05). The current study identified altered blood biological factors in calves with infectious diarrhea. The results suggested that these factors may be useful targets for monitoring animal health in calf diarrheal disease, especially infectious diarrhea. | Kim, Suhee; Yu, Do-Hyeon; Jung, Sukhan; Kang, Jinhee; Park, Kwangman; Chae, Jeong-Byoung; Choi, Kyoung-Seong; Kim, Hyeon-Cheol; Park, Bae-Keun; Chae, Joon-Seok; Park, Jinho | Gyeongsang Natl Univ Hosp, Dept Internal Med, Jinju 52727, South Korea; Gyeongsang Natl Univ Hosp, Inst Hlth Sci, Jinju 52727, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Jinju 52828, South Korea; Rural Dev Adm, Natl Inst Anim Sci, Wonju 55365, South Korea; Jeonbuk Natl Univ, Coll Vet Med, Iksan 54596, South Korea; Seoul Natl Univ, Res Inst Vet Sci, Lab Vet Internal Med, BK21 Plus Program Creat Vet Sci Res, Seoul 08826, South Korea; Seoul Natl Univ, Coll Vet Med, Seoul 08826, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Sangju 37224, South Korea; Kangwon Natl Univ, Coll Vet Med, Chunchon 24341, South Korea; Chungnam Natl Univ, Coll Vet Med, Daejeon 34134, South Korea | Chae, Jeong/AAP-6038-2021 | 36614279700; 14623495400; 57210209134; 57210211499; 57219435315; 57037983200; 7403949556; 35345454300; 37043844700; 7102478039; 8730126700 | jpark@jbnu.ac.kr; | PAKISTAN VETERINARY JOURNAL | PAK VET J | 0253-8318 | 2074-7764 | 41 | 4 | SCIE | VETERINARY SCIENCES | 2021 | 1.803 | 39.0 | 1.85 | 2025-07-30 | 7 | 10 | Acute phase protein; Calf; Diarrhea; Hemato-chemical parameter; Pathogen; Pro-inflammatory cytokine | ACUTE-PHASE PROTEINS; NEONATAL CALF DIARRHEA; EIMERIA-ZUERNII INFECTION; DAIRY; CORONAVIRUS; ETIOLOGY; DISEASE | Acute phase protein; Calf; Diarrhea; Hemato-chemical parameter; Pathogen; Pro-inflammatory cytokine | acute phase protein; albumin; biological factor; biological marker; C reactive protein; chloride; cytokine; fibrinogen; haptoglobin; interleukin 6; nitrogen; phosphorus; potassium; protein; sodium; tumor necrosis factor; animal experiment; animal tissue; Article; blood cell count; blood chemistry; blood sampling; Bovine coronavirus; Bovine rotavirus A; Bovine viral diarrhea virus 1; calf (bovine); cattle disease; clinical examination; clinical feature; controlled study; Cryptosporidium; cytokine production; disease exacerbation; Eimeria; enteropathogen; enzyme linked immunosorbent assay; Escherichia coli; feces analysis; Giardia; infectious diarrhea; microorganism detection; microscopy; nonhuman; prevalence; real time polymerase chain reaction; Salmonella; sampling; urea nitrogen blood level | English | 2021 | 2021 | 10.29261/pakvetj/2021.078 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Matched Comparison of Bone Transport Using External Fixator Over a Nail Versus External Fixator Over a Plate for Segmental Tibial Bone Defects | Objective: To compare the outcomes and complications of bone transport over a nail (BTON) with those of bone transport over a plate (BTOP) for segmental tibial bone defects. Design: Retrospective matched study design. Setting: A major metropolitan tertiary referral trauma center. Patients: Thirty-six patients with segmental tibial bone defects of >4 cm were included in this study. Intervention: Either BTON or BTOP was performed on 18 patients. Main Outcome Measurements: We compared the healing of the distraction process and of the docking site between the techniques. Distraction parameters including external fixator (EF) time, external fixation index, and healing index were compared. Bone and functional results were compared according to the Paley-Maar classification. Complications associated with each procedure were compared. Results: Both BTON and BTOP achieved similar rates of primary union (83% vs. 89%) at the distraction or docking site. Significantly less time wearing an EF was needed for BTOP than for BTON (2.8 vs. 5.4 months; P < 0.01). The external fixation index was significantly lower for BTOP than for BTON (0.45 vs. 0.94 mo/cm; P < 0.01), whereas the healing indexes were similar. The final outcomes and complication incidences were not significantly different. Conclusions: The EF time was significantly shorter for BTOP than for BTON; however, the final outcomes were similar. Therefore, BTOP could be considered an attractive option for bone transport in patients with segmental tibial defects. | Park, Kyeong-Hyeon; Oh, Chang-Wug; Kim, Joon-Woo; Oh, Jong-Keon; Yoon, Yong-Cheol; Seo, Il; Ha, Sung-Soo; Chung, Seung-Ho | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthopaed Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Korea Univ, Sch Med, Dept Orthopaed Surg, Guro Hosp, Seoul, South Korea; Gachon Univ, Trauma Ctr, Orthopaed Trauma Div, Coll Med, Incheon, South Korea | Yong-Cheol, Yoon/HPD-8077-2023; Park, KyeongHyeon/KEH-4919-2024; Oh, Chang-Wug/AAO-4602-2021 | cwoh@knu.ac.kr; | JOURNAL OF ORTHOPAEDIC TRAUMA | J ORTHOP TRAUMA | 0890-5339 | 1531-2291 | 35 | 11 | SCIE | ORTHOPEDICS;SPORT SCIENCES | 2021 | 2.884 | 39.0 | 8 | bone transport; plate; nail; segmental bone defect; external fixator | INTRAMEDULLARY NAIL; RECONSTRUCTION; COMPLICATIONS; MANAGEMENT; NONUNIONS; REPAIR | English | 2021 | 2021-11 | 10.1097/bot.0000000000002084 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | An Update on Trichoderma Mitogenomes: Complete De Novo Mitochondrial Genome of the Fungal Biocontrol Agent Trichoderma harzianum (Hypocreales, Sordariomycetes), an Ex-Neotype Strain CBS 226.95, and Tracing the Evolutionary Divergences of Mitogenomes in Trichoderma | Members of the genus Trichoderma (Hypocreales), widely used as biofungicides, biofertilizers, and as model fungi for the industrial production of CAZymes, have actively been studied for the applications of their biological functions. Recently, the study of the nuclear genomes of Trichoderma has expanded in the directions of adaptation and evolution to gain a better understanding of their ecological traits. However, Trichoderma's mitochondria have received much less attention despite mitochondria being the most necessary element for sustaining cell life. In this study, a mitogenome of the fungus Trichoderma harzianum CBS 226.95 was assembled de novo. A 27,632 bp circular DNA molecule was revealed with specific features, such as the intronless of all core PCGs, one homing endonuclease, and a putative overlapping tRNA, on a closer phylogenetic relationship with T. reesei among hypocrealean fungi. Interestingly, the mitogenome of T. harzianum CBS 226.95 was predicted to have evolved earlier than those of other Trichoderma species and also assumed with a selection pressure in the cox3. Considering the bioavailability, both for the ex-neotype strain of the T. harzianum species complex and the most globally representative commercial fungal biocontrol agent, our results on the T. harzianum CBS 226.95 mitogenome provide crucial information which will be helpful criteria in future studies on Trichoderma. | Kwak, Yunyoung | Univ Paris Saclay, Univ Paris Sud Paris XI, Ecol Systemat & Evolut, AgroParisTech,CNRS, F-91400 Orsay, France; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Qual & Safety Assessment Agr Prod, Daegu 41566, South Korea | 24724461200 | yun@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 9 | 8 | SCIE | MICROBIOLOGY | 2021 | 4.926 | 39.1 | 0.66 | 2025-07-30 | 9 | 9 | divergence; divergence time; evolution; fungal mitochondrial genome; fungal mitogenome; selective pressure; Trichoderma | PHYLOGENETIC ANALYSIS; SOFTWARE; SYSTEMATICS; EXPANSION; INTRONS; BIOLOGY; MODELS; RNAS; TOOL | Divergence; Divergence time; Evolution; Fungal mitochondrial genome; Fungal mitogenome; Selective pressure; Trichoderma | English | 2021 | 2021-08 | 10.3390/microorganisms9081564 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Characterization of a New and Efficient Polyvalent Phage Infecting E. coli O157:H7, Salmonella spp., and Shigella sonnei | Ongoing outbreaks of foodborne diseases remain a significant public health concern. Lytic phages provide promising attributes as biocontrol agents. This study characterized KFS-EC3, a polyvalent and lytic phage, which was isolated from slaughterhouse sewage and purified by cesium chloride density centrifugation. Host range and efficiency of plating analyses revealed that KFS-EC3 is polyvalent and can efficiently infect E. coli O157:H7, Salmonella spp., and Shigella sonnei. KFS-EC3 had a latent time of 20 min and burst size of similar to 71 phages/infected cell. KFS-EC3 was stable and infectious following storage at a pH range of 3 to 11 and a temperature range of -70 degrees C to 60 degrees C. KFS-EC3 could inhibit E. coli O157:H7 growth by 2 logs up to 52 h even at the lowest MOI of 0.001. Genomic analysis of KFS-EC3 revealed that it consisted of 167,440 bp and 273 ORFs identified as functional genes, without any genes associated with antibiotic resistance, virulence, allergenicity, and lysogenicity. This phage was finally classified into the Tequatrovirus genus of the Myoviridae family. In conclusion, KFS-EC3 could simultaneously infect E. coli O157:H7, S. sonnei, and Salmonella spp. with the lowest MOI values over long periods, suggesting its suitability for simultaneous pathogen control in foods. | Kim, Su-Hyeon; Adeyemi, Damilare Emmanuel; Park, Mi-Kyung | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Inst, Daegu 41566, South Korea | ; Park, Mi-Kyung/J-9643-2017 | 57217051011; 57211002020; 7404491155 | 1sh_hs1@naver.com;atidamilare1@gmail.com;parkmik@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 9 | 10 | SCIE | MICROBIOLOGY | 2021 | 4.926 | 39.1 | 1.54 | 2025-07-30 | 28 | 26 | polyvalent phage; effectiveness; Escherichia coli O157:H7; Salmonella; Shigella sonnei | BIOCONTROL; BACTERIOPHAGES; TYPHIMURIUM; OUTBREAKS; COCKTAIL; ENTERICA; TRENDS; GENES | Effectiveness; Escherichia coli O157:H7; Polyvalent phage; Salmonella; Shigella sonnei | English | 2021 | 2021-10 | 10.3390/microorganisms9102105 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Characterization of Cold-Tolerant Saccharomyces cerevisiae Cheongdo Using Phenotype Microarray | The cold-tolerant yeast Saccharomyces cerevisiae is industrially useful for lager fermentation, high-quality wine, and frozen dough production. S. cerevisiae Cheongdo is a recent isolate from frozen peach samples which has a good fermentation performance at low temperatures and desirable flavor profiles. Here, phenotype microarray was used to investigate industrial potentials of S. cerevisiae Cheongdo using 192 carbon sources. Compared to commercial wine yeast S. cerevisiae EC1118, Cheongdo showed significantly different growth rates on 34 substrates. The principal component analysis of the results highlighted that the better growth of Cheongdo on galactose than on EC1118 was the most significant difference between the two strains. The intact GAL4 gene and the galactose fermentation performance at a low temperatures suggested that S. cerevisiae Cheongdo is a promising host for industrial fermentation rich in galactose, such as lactose and agarose. | Jung, Kyung-Mi; Park, Jongbeom; Jang, Jueun; Jung, Seok-Hwa; Lee, Sang Han; Kim, Soo Rin | Gyeongsangbuk Do Agr Technol Adm, Cheongdo Peach Res Inst, Cheongdo 38315, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Kim, Soo Rin/X-2192-2019; Lee, Seung Eun/ABG-1607-2021 | 57196472095; 57223133187; 57223137781; 57223137228; 57221453703; 36659584200 | kmgod@korea.kr;whdqja5743@naver.com;hazel515@daum.net;jshtjrghk0@gmail.com;sang@knu.ac.kr;soorinkim@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 9 | 5 | SCIE | MICROBIOLOGY | 2021 | 4.926 | 39.1 | 0.22 | 2025-07-30 | 2 | 3 | phenotype microarray; yeast; cold tolerance; galactose; GAL4 | FERMENTATION PERFORMANCE; GALACTOSE FERMENTATION; ETHANOL-PRODUCTION; YEAST; GENOME; WILD; IDENTIFICATION; ADAPTATION; CONVERSION; GENOTYPE | Cold tolerance; GAL4; Galactose; Phenotype microarray; Yeast | English | 2021 | 2021-05 | 10.3390/microorganisms9050982 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Fecal Microbiome and Resistome Profiling of Healthy and Diseased Pakistani Individuals Using Next-Generation Sequencing | In this paper, we aimed to characterize the fecal microbiome and its resistomes of healthy and diseased subjects infected with multidrug-resistant Escherichia coli using next-generation sequencing (NGS). After initial screening, 26 stools samples belonging to healthy (n = 13) and diseased subjects (n = 13) were selected and subjected to NGS. A total of 23 and 42 antibiotic-resistant genes (ARGs) conferring resistance to 6 and 9 classes of antibiotics were identified in the resistomes of healthy and diseased subjects, respectively. Bacteroidetes were found to be the major phylum in both healthy and diseased subjects; however, Proteobacteria was predominantly present in the diseased subjects only. Microbial dysbiosis and predominance of various ARGs in the resistome of diseased subjects reflect the excessive usage of antibiotics in Pakistan and warrants immediate attention to regulate the use of various antimicrobials. | Afridi, Ome Kalsoom; Ali, Johar; Chang, Jeong Ho | Kyungpook Natl Univ, Dept Biol Educ, 80 Daehak Ro, Daegu 41566, South Korea; Rehman Med Coll, Ctr Genome Sci, Phase 5, Peshawar 25000, Pakistan; Sukkur Inst Business Adm Univ, Execut Dev Ctr, Sindh 65200, Pakistan; AlviArmani Int, Mississauga, ON M4W 3E2, Canada; CECOS Univ IT & Emerging Sci, Inst Integrat Biosci, Dept Biotechnol, Peshawar 25000, Pakistan | 57218250521; 57213890686; 57203598905 | ummeafridi@gmail.com;Johar.alil@rmi.edu.pk;jhcbio@knu.ac.kr;Johar.ali1@rmi.edu.pk; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 9 | 3 | SCIE | MICROBIOLOGY | 2021 | 4.926 | 39.1 | 0.44 | 2025-07-30 | 7 | 7 | antibiotics; gut microbiota; next-generation sequencing; microbial dysbiosis; loss of microbiota diversity | INTESTINAL MICROBIOTA; ANTIMICROBIAL RESISTANCE; GUT MICROBIOTA; ANTIBIOTICS; IMPACT | Antibiotics; Gut microbiota; Loss of mi-crobiota diversity; Microbial dysbiosis; Next-generation sequencing | English | 2021 | 2021-03 | 10.3390/microorganisms9030616 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Geographical Relationships between Long-Tailed Goral (Naemorhedus caudatus) Populations Based on Gut Microbiome Analysis | The long-tailed goral (Naemorhedus caudatus) is an endangered species found in the mountains of eastern and northern Asia. Its populations have declined for various reasons, and this species has been designated as legally protected in South Korea. Although various ecological studies have been conducted on long-tailed gorals, none have investigated the gut microbiome until now. In the present study, we compared the diversity and composition of the gut microbiome of seven populations of Korean long-tailed gorals. By analyzing the gut microbiome composition for each regional population, it was found that four phyla-Firmicutes, Actinobacteriota, Bacteroidota, and Proteobacteria-were the most dominant in all regions on average. The alpha diversity of the gut microbiome of the goral population in the northern regions was high, while that in the southern regions was low. Through the analysis of beta diversity, the seven long-tailed goral populations have been divided into three groups: the Seoraksan population, the Samcheock population, and the Wangpicheon population. It was possible to confirm the regional migration of the animals using the gut microbiome based on the site-relational network analysis. It was found that the most stable population of long-tailed gorals in Korea was the Seoraksan population, and the closely related groups were the Samcheok and Wangpicheon populations, respectively. Wangpicheon appeared to be a major point of dispersal in the migration route of Korean long-tailed gorals. | Park, Chang Eon; Cho, Bum-Joon; Kim, Min-Ji; Park, Hee Cheon; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Assoc Ex Situ Conservat, Inst Ornithol, Daegu 41541, South Korea; Wildlife Union, Donghae 25802, South Korea | ; Park, Chang Eon/ACL-1997-2022 | 57213511897; 57264158400; 57127351600; 56779256600; 57224125922 | aeonrapt@knu.ac.kr;hl2xsg@hanmail.net;tbd01188@gmail.com;cranesave@naver.com;jhshin@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 9 | 9 | SCIE | MICROBIOLOGY | 2021 | 4.926 | 39.1 | 0.29 | 2025-07-30 | 5 | 4 | Naemorhedus caudatus; long-tailed goral; geographical relationship; gut microbiome; 16s rRNA sequencing; endangered species; ruminant; network analysis | SEASONAL MIGRATION; HOME-RANGE; DEER; ZEBRAFISH; CAPREOLUS; PATTERNS | 16s rRNA sequencing; Endangered species; Geographical relationship; Gut microbiome; Long-tailed goral; Naemorhedus caudatus; Network analysis; Ruminant | English | 2021 | 2021-09 | 10.3390/microorganisms9092002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | HbxB Is a Key Regulator for Stress Response and β-Glucan Biogenesis in Aspergillus nidulans | Homeobox transcription factors are conserved in eukaryotes and act as multi-functional transcription factors in filamentous fungi. Previously, it was demonstrated that HbxB governs fungal development and spore viability in Aspergillus nidulans. Here, the role of HbxB in A. nidulans was further characterized. RNA-sequencing revealed that HbxB affects the transcriptomic levels of genes associated with trehalose biosynthesis and response to thermal, oxidative, and radiation stresses in asexual spores called conidia. A phenotypic analysis found that hbxB deletion mutant conidia were more sensitive to ultraviolet stress. The loss of hbxB increased the mRNA expression of genes associated with beta-glucan degradation and decreased the amount of beta-glucan in conidia. In addition, hbxB deletion affected the expression of the sterigmatocystin gene cluster and the amount of sterigmatocystin. Overall, these results indicated that HbxB is a key transcription factor regulating trehalose biosynthesis, stress tolerance, beta-glucan degradation, and sterigmatocystin production in A. nidulans conidia. | Son, Sung-Hun; Lee, Mi-Kyung; Son, Ye-Eun; Park, Hee-Soo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Biol Resource Ctr BRC, Jeongeup Si 56212, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea | Park, Hee-Soo/AAC-6422-2019 | 57214091244; 57221217721; 57200513491; 15751448400 | rk05555@naver.com;miklee1010@kribb.re.kr;thsdpdms0407@naver.com;phsoo97@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 9 | 1 | SCIE | MICROBIOLOGY | 2021 | 4.926 | 39.1 | 0.51 | 2025-07-30 | 7 | 7 | conidia; homeobox domain; RNA-sequencing analysis; transcription factor; sterigmatocystin; Aspergillus nidulans | HOMEODOMAIN PROTEINS; ASEXUAL SPORULATION; DIFFERENTIATION; GENE | Aspergillus nidulans; Conidia; Homeobox domain; RNA-sequencing analysis; Sterigmatocystin; Transcription factor | English | 2021 | 2021-01 | 10.3390/microorganisms9010144 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Potential Association between Vaginal Microbiota and Cervical Carcinogenesis in Korean Women: A Cohort Study | Convincing studies demonstrated that vaginal flora is one of the most impactful key components for the well-being of the genital tract in women. Nevertheless, the potential capability of vaginal-derived bacterial communities as biomarkers to monitor cervical carcinogenesis (CC) has yet to be studied actively compared to those of bacterial vaginosis (BV). We hypothesized that vaginal microbiota might be associated with the progression of CC. In this study, we enrolled 23 participants, including healthy controls (HC group; n = 7), patients with cervical intraepithelial neoplasia (CIN) 2 and 3 (CIN group, n = 8), and patients with invasive cervical cancer (CAN group; n = 8). Amplicon sequencing was performed using the Ion Torrent PGM to characterize the vaginal microbiota. Patients with CIN and CAN presented vaginal microbiota dysbiosis compared with HC. The alpha diversity analysis revealed that CC has a trend to be increased in terms of diversity indexes. Moreover, CC was associated with the abundance of specific microbes, of which Lactobacillus and Gardnerella were the most significantly different between HC and CIN, whereas Streptococcus was differentially abundant in CAN compared with CIN. We then evaluated their diagnostic abilities. Testing in terms of diagnostic ability using the three genera revealed considerably high performance with an area under the receiver-operating characteristic curve of 0.982, 0.953, and 0.922. The current study suggests that the presence of Gardnerella and Streptococcus may be involved in the advancment of CC. | Kang, Gi-Ung; Jung, Da-Ryung; Lee, Yoon Hee; Jeon, Se Young; Han, Hyung Soo; Chong, Gun Oh; Shin, Jae-Ho | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Dept Obstet & Gynecol, Chilgok Hosp, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41405, South Korea | 57211635810; 57221116102; 37088851700; 57216296837; 7401969388; 23099068000; 57224125922 | gukang@knu.ac.kr;amugae1210@knu.ac.kr;mylyh3@naver.com;tpqkf0927@naver.com;hshan@knu.ac.kr;gochong@knu.ac.kr;jhshin@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 9 | 2 | SCIE | MICROBIOLOGY | 2021 | 4.926 | 39.1 | 2.41 | 2025-07-30 | 42 | 40 | vaginal microbiome; CIN severity; CIN prediction; vaginosis | HUMAN-PAPILLOMAVIRUS; BACTERIAL VAGINOSIS; GUT-MICROBIOTA; CANCER; DIVERSITY; COLONIZATION; LACTOBACILLI; SIGNATURE; INFECTION; HEALTH | CIN prediction; CIN severity; Vaginal microbiome; Vaginosis | English | 2021 | 2021-02 | 10.3390/microorganisms9020294 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Comparison of Intaglio Surface Trueness of Interim Dental Crowns Fabricated with SLA 3D Printing, DLP 3D Printing, and Milling Technologies | This study aimed to evaluate the intaglio surface trueness of interim dental crowns fabricated with three 3-dimensional (3D) printing and milling technologies. Dental crown was designated and assigned as a computer-aided design (CAD) reference model (CRM). Interim dental crowns were fabricated based on CRM using two types of 3D printer technologies (stereolithography apparatus and digital light processing) and one type of milling machine (n = 15 per technology). The fabricated interim dental crowns were obtained via 3D modeling of the intaglio surface using a laboratory scanner and designated as CAD test models (CTMs). The alignment and 3D comparison of CRM and CTM were performed based on the intaglio surface using a 3D inspection software program (Geomagic Control X). Statistical analysis was validated using one-way analysis of variance and Tukey HSD test (alpha = 0.05). There were significant differences in intaglio surface trueness between the three different fabrication technologies, and high trueness values were observed in the milling group (p < 0.05). In the milling group, there was a significant difference in trueness according to the location of the intaglio surface (p < 0.001). In the manufacturing process of interim dental crowns, 3D printing technologies showed superior and uniform manufacturing accuracy than milling technology. | Son, Keunbada; Lee, Jung-Ho; Lee, Kyu-Bok | Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, Daegu 41940, South Korea; Kyungpook Natl Univ, Adv Dent Device Dev Inst, Daegu 41940, South Korea; SAESHIN, 52,Secheon Ro 1 Gil, Dalseong Gun 42941, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu 41940, South Korea | Son, Keunbada/AAG-8089-2019; SON, Keunbada/AAG-8089-2019 | 57202916520; 57226683472; 15925571200 | sonkeunbada@gmail.com;president@saeshin.com;kblee@knu.ac.kr; | HEALTHCARE | HEALTHCARE-BASEL | 2227-9032 | 9 | 8 | SCIE;SSCI | HEALTH CARE SCIENCES & SERVICES;HEALTH POLICY & SERVICES | 2021 | 3.16 | 39.2 | 3.12 | 2025-07-30 | 41 | 46 | trueness; 3D printing; milling; interim dental crown; digital dentistry; dental device | 3-DIMENSIONAL ACCURACY; IMPLANT IMPRESSIONS; INTRAORAL SCANNER; COMPLETE-ARCH; PRECISION; REPRODUCIBILITY | 3D printing; Dental device; Digital dentistry; Interim dental crown; Milling; Trueness | English | 2021 | 2021-08 | 10.3390/healthcare9080983 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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