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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Association between eupatilin and reduction in small bowel bleeding in aspirin users and aspirin plus acid suppressant users | Background/Aims: Capsule endoscopy (CE) has shown that low-dose aspirin occasionally causes small bowel (SB) bleeding. We herein evaluated the protective effects of mucoprotective agents (MPAs) on SB bleeding in aspirin users using the nationwide database of claims data from the National Health Insurance Service (NHIS).Methods: As CE is an insured procedure, we constructed an aspirin-SB cohort using NHIS claims data, with a maximum follow-up period of 24 months. Patients with anemia, melena, or hematochezia that occurred within 4 weeks before and after performing CE were suspected to have SB bleeding. A Cox proportional hazards regression model was used to determine the risk factors for SB bleeding. Subgroup analyses were conducted among patients who used acid suppressants, such as proton pump inhibitors (PPIs) and histamine-2 receptor antagonists.Results: A total of 15,542 aspirin users were included. Anticoagulant use (hazard ratio [HR], 3.22), high Charlson comorbidity index score (>= 2) (HR, 3.54), and PPI use (HR, 2.85) were significantly associated with SB bleeding, whereas eupatilin use (HR, 0.35) was a preventive factor. SB bleeding occurred more frequently in concurrent users of acid suppressants than in nonusers (1.3% vs. 0.5%). Subgroup analysis revealed that eupatilin significantly reduced the risk of SB bleeding in aspirin users with concurrent use of acid suppressants (HR, 0.23 vs. 2.55).Conclusions: Eupatilin was associated with a reduced risk of SB bleeding in both aspirin users and those with concomitant use of acid suppressants. Eupatilin use should be considered for aspirin users, especially for those concomitantly taking acid suppressants. | Lee, Hyun Seok; Nam, Ji Hyung; Oh, Dong Jun; Ahn, Hyun Jung; Lim, Yun Jeong | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Dongguk Univ, Coll Med, Dept Internal Med, Ilsan Hosp, Goyang, South Korea; Linewalks Inc, Data Analyt Team, Seoul, South Korea; Dongguk Univ, Ilsan Hosp, Dept Internal Med, Coll Med,Div Gastroenterol, 27 Dongguk Ro, Goyang 10326, South Korea | LIM, Yun Jeong/KVY-6446-2024 | 36647886100; 42361607200; 57203029221; 58478247500; 56501161800 | drlimyj@gmail.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 38 | 4 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 2.2 | 28.1 | 0.65 | 2025-06-25 | 4 | 4 | Aspirin; Capsule endoscopy; Eupatilin; Anti-ulcer agents; Gastrointestinal hemorrhage | SMALL-INTESTINAL INJURY; PROTON PUMP INHIBITORS; CAPSULE ENDOSCOPY; MULTICENTER; PREVENTION; REBAMIPIDE | Anti-ulcer agents; Aspirin; Capsule endoscopy; Eupatilin; Gastrointestinal hemorrhage | Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Flavonoids; Gastrointestinal Hemorrhage; Humans; Proton Pump Inhibitors; Risk Factors; acetylsalicylic acid; alginic acid; anticoagulant agent; antiulcer agent; antivitamin K; bismuth; cilostazol; clopidogrel; dipyridamole; ecabet; eupatilin; histamine H2 receptor antagonist; irsogladine maleate; misoprostol; polaprezinc; prasugrel; proton pump inhibitor; rebamipide; sucralfate; sulglicotide; teprenone; ticagrelor; troxipide; unclassified drug; warfarin; eupatilin; flavonoid; nonsteroid antiinflammatory agent; proton pump inhibitor; adult; aged; anemia; Article; capsule endoscopy; Charlson Comorbidity Index; cohort analysis; controlled study; drug utilization; female; follow up; hazard ratio; hematochezia; human; intestinal bleeding; major clinical study; male; melena; prescription; proportional hazards model; risk assessment; risk factor; risk reduction; small intestine; gastrointestinal hemorrhage | English | 2023 | 2023-07 | 10.3904/kjim.2022.340 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Detection of COVID-19 epidemic outbreak using machine learning | BackgroundThe coronavirus disease (COVID-19) pandemic has spread rapidly across the world, creating an urgent need for predictive models that can help healthcare providers prepare and respond to outbreaks more quickly and effectively, and ultimately improve patient care. Early detection and warning systems are crucial for preventing and controlling epidemic spread.ObjectiveIn this study, we aimed to propose a machine learning-based method to predict the transmission trend of COVID-19 and a new approach to detect the start time of new outbreaks by analyzing epidemiological data.MethodsWe developed a risk index to measure the change in the transmission trend. We applied machine learning (ML) techniques to predict COVID-19 transmission trends, categorized into three labels: decrease (L0), maintain (L1), and increase (L2). We used Support Vector Machine (SVM), Random Forest (RF), and XGBoost (XGB) as ML models. We employed grid search methods to determine the optimal hyperparameters for these three models. We proposed a new method to detect the start time of new outbreaks based on label 2, which was sustained for at least 14 days (i.e., the duration of maintenance). We compared the performance of different ML models to identify the most accurate approach for outbreak detection. We conducted sensitivity analysis for the duration of maintenance between 7 days and 28 days.ResultsML methods demonstrated high accuracy (over 94%) in estimating the classification of the transmission trends. Our proposed method successfully predicted the start time of new outbreaks, enabling us to detect a total of seven estimated outbreaks, while there were five reported outbreaks between March 2020 and October 2022 in Korea. It means that our method could detect minor outbreaks. Among the ML models, the RF and XGB classifiers exhibited the highest accuracy in outbreak detection.ConclusionThe study highlights the strength of our method in accurately predicting the timing of an outbreak using an interpretable and explainable approach. It could provide a standard for predicting the start time of new outbreaks and detecting future transmission trends. This method can contribute to the development of targeted prevention and control measures and enhance resource management during the pandemic. | Cho, Giphil; Park, Jeong Rye; Choi, Yongin; Ahn, Hyeonjeong; Lee, Hyojung | Kangwon Natl Univ, Dept Artificial Intelligence & Software, Samcheok Si, South Korea; Kyungpook Natl Univ, Dept Math, Daegu, South Korea; Natl Inst Math Sci, Busan Ctr Med Math, Daejeon, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea | Park, Jeong Rye/MDS-8129-2025; Choi, Yongin/GSD-3776-2022 | 56665111500; 56471031400; 57204844522; 58029969000; 57196021198 | hjlee@knu.ac.kr; | FRONTIERS IN PUBLIC HEALTH | FRONT PUBLIC HEALTH | 2296-2565 | 11 | SCIE;SSCI | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2023 | 3 | 28.1 | 1.82 | 2025-06-25 | 8 | 8 | COVID-19; prediction; machine learning; early detection; outbreak | SUPPORT | COVID-19; early detection; machine learning; outbreak; prediction | COVID-19; Disease Outbreaks; Health Personnel; Humans; Machine Learning; Pandemics; coronavirus disease 2019; epidemic; health care personnel; human; machine learning; pandemic | English | 2023 | 2023-12-18 | 10.3389/fpubh.2023.1252357 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Effectiveness of sleep interventions for rotating night shift workers: a systematic review and meta-analysis | Background: Sleep disturbance is a common issue among rotating night shift workers and is closely related to health risks. The present study aimed to determine the effectiveness of pharmacological and non-pharmacological sleep interventions for the management of sleep disturbance among rotating night shift workers.Methods: For this systematic review and meta-analysis, we searched six electronic databases-EMBASE, CINAHL, Cochrane Library, PubMed, Scopus, and Web of Science-for randomized controlled trials and clinical trials published from January 1990 to June 2022. The quality of eligible studies was independently assessed by three authors using the Joanna Briggs Institute Critical Appraisal Checklist for randomized controlled trials and quasi-experimental studies. The meta-analysis was performed based on the random effects model using the Comprehensive Meta-Analysis software. The study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Results: Of the 1019 studies retrieved, 30 met the inclusion criteria for the systematic review; 25 were selected for the meta-analysis. Sleep interventions were categorized as follows: pharmacological approach (n = 7), light therapy (n = 9), cognitive behavioral approach (n = 7), aroma or alternative therapy (n = 4), and shift schedule modification (n = 3). The overall mean effect size of the interventions was moderate (Hedges' g = 0.59; 95% confidence interval = 0.33-0.84, z = 4.50, p < 0.001).Conclusion: Sleep interventions were effective in promoting sleep or reducing sleep disturbance among rotating night shift workers. These findings provide evidence of the effectiveness of various pharmacological and non-pharmacological sleep interventions for managing sleep health in the work environment of rotating night shift workers. | Jeon, Bo Min; Kim, Su Hyun; Shin, Seung Hwa | Kyungpook Natl Univ, Coll Nursing, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, Daegu, South Korea; Andong Sci Coll, Dept Nursing, Andong, South Korea | kim, su/AAK-6271-2021 | 58461384500; 56664542600; 57224006486 | suhyun_kim@knu.ac.kr; | FRONTIERS IN PUBLIC HEALTH | FRONT PUBLIC HEALTH | 2296-2565 | 11 | SCIE;SSCI | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2023 | 3 | 28.1 | 0.49 | 2025-06-25 | 5 | 5 | shift work schedule; sleep; sleep-wake disorders; systematic review and meta-analysis; sleep interventions | BRIGHT LIGHT; NONPHARMACOLOGICAL INTERVENTIONS; IMPROVE ADAPTATION; MELATONIN; EXPOSURE; HEALTH; INSOMNIA; ATTENUATION; SCHEDULES; PERMANENT | shift work schedule; sleep; sleep interventions; sleep-wake disorders; systematic review and meta-analysis | Cognitive Behavioral Therapy; Complementary Therapies; Humans; Sleep; Sleep Wake Disorders; alternative medicine; cognitive behavioral therapy; human; meta analysis; sleep; sleep disorder | English | 2023 | 2023-06-22 | 10.3389/fpubh.2023.1187382 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Efficacy and safety of 1 L polyethylene glycol plus ascorbic acid for bowel preparation in elderly: comparison with oral sulfate solution | Background/Aims: Recently, 1 L of polyethylene glycol (PEG) plus ascorbic acid (Asc) has been introduced in Korea as a colonoscopy preparation agent. Data on its efficacy and safety in older adults have been limited. We aimed to evaluate the safety and efficacy of 1 L PEG/Asc in older adults by comparing it with oral sulfate solution (OSS). Methods: A prospective multicenter randomized study was conducted with subjects aged >= 65 years who underwent colonoscopy. The participants were randomized to receive 1 L PEG/Asc or OSS. The primary endpoint was successful bowel preparation, defined as total Boston Bowel Preparation Scale >= 6, and >= 2 at each segment. Patient satisfaction, adverse events, and renal function changes were compared between the groups. Results: Among the 106 patients, 104 were finally included in the analysis. Overall, successful bowel preparation was achieved in 96.2% of both 1 L PEG/Asc and OSS groups. The satisfaction scores for taste, total amount ingested, overall feeling, and willingness to repeat the same regimen were not significantly different between the groups. Adverse events of moderate or higher severity occurred in 16 and 10 cases in the 1 L PEG/Asc and OSS group, respectively. There were no significant changes in electrolyte levels or renal function from baseline. Conclusions: The successful bowel preparation rate was > 90% in both groups without severe adverse effects and significant changes in renal function. As a new low-dose preparation regimen for colonoscopy in older adults, 1 L PEG/Asc, is as effective and safe as OSS. | Lim, Ki Young; Kim, Kyeong Ok; Kim, Eun Young; Lee, Yoo Jin; Jang, Byung Ik; Kim, Sung Kook; Yang, Chang Heon | Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yeungnam Univ, Hlth Promot Ctr, Coll Med, Daegu, South Korea; Dongguk Univ, Dept Internal Med, Sch Med, Gyeongju, South Korea | Lee, Yoojin/AAB-9799-2022; Kwak, Sang Gyu/AAG-4341-2021; Kim, Eun Young/JCE-3602-2023 | 57272285300; 53363798100; 58889004100; 55531365900; 22953491400; 34770060400; 23089577400 | kokim@yu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 38 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 2.2 | 28.1 | 0.49 | 2025-06-25 | 3 | 3 | Colonoscopy; Cathartics; Polyethylene glycol; Oral sulfate solution | LOW-VOLUME PEG; GASTROINTESTINAL ENDOSCOPY; COLONOSCOPY PREPARATION; ADENOMA DETECTION; EUROPEAN-SOCIETY; RANDOMIZED-TRIAL; POLYP DETECTION; MORTALITY; OLDER | Cathartics; Colonoscopy; Oral sulfate solution; Polyethylene glycol | Aged; Ascorbic Acid; Cathartics; Colonoscopy; Humans; Polyethylene Glycols; Prospective Studies; Single-Blind Method; Sulfates; ascorbic acid plus polyethylene glycol; laxative; sulfate; unclassified drug; ascorbic acid; laxative; macrogol; sulfate; aged; Article; colonoscopy; controlled study; disease severity; drug efficacy; drug safety; drug tolerability; elderly care; female; food intake; human; intestine preparation; kidney function; major clinical study; male; multicenter study; outcome assessment; patient satisfaction; prospective study; randomized controlled trial; visual analog scale; clinical trial; single blind procedure | English | 2023 | 2023-09 | 10.3904/kjim.2023.030 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Efficacy and safety of sofosbuvir-velpatasvir and sofosbuvir-velpatasvir-voxilaprevir for hepatitis C in Korea: a Phase 3b study | Background/Aims: Despite the availability of direct-acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection in Korea, need remains for pangenotypic regimens that can be used in the presence of hepatic impairment, comorbidities, or prior treatment failure. We investigated the efficacy and safety of sofosbuvir-velpatasvir and sofosbuvir-velpatasvir-voxila-previr for 12 weeks in HCV-infected Korean adults.Methods: This Phase 3b, multicenter, open-label study included 2 cohorts. In Cohort 1, participants with HCV genotype 1 or 2 and who were treatment-naive or treatment-experienced with interferon-based treatments, received sofosbuvir-velpat-asvir 400/100 mg/day. In Cohort 2, HCV genotype 1 infected individuals who previously received an NS5A inhibitor -contain-ing regimen >= 4 weeks received sofosbuvir-velpatasvir-voxilaprevir 400/100/100 mg/day. Decompensated cirrhosis was an exclusion criterion. The primary endpoint was SVR12, defined as HCV RNA < 15 IU/mL 12 weeks following treatment.Results: Of 53 participants receiving sofosbuvir-velpatasvir, 52 (98.1%) achieved SVR12. The single participant who did not achieve SVR12 experienced an asymptomatic Grade 3 ASL/ALT elevation on day 15 and discontinued treatment. The event resolved without intervention. All 33 participants (100%) treated with sofosbuvir-velpatasvir-voxilaprevir achieved SVR 12. Overall, sofosbuvir-velpatasvir and sofosbuvir-velpatasvir-voxilaprevir were safe and well tolerated. Three participants (5.6%) in Cohort 1 and 1 participant (3.0%) in Cohort 2 had serious adverse events, but none were considered treatment-related. No deaths or grade 4 laboratory abnormalities were reported.Conclusions: Treatment with sofosbuvir-velpatasvir or sofosbuvir-velpatasvir-voxilaprevir was safe and resulted in high SVR12 rates in Korean HCV patients. | Heo, Jeong; Kim, Yoon Jun; Lee, Sung Wook; Lee, Youn-Jae; Yoon, Ki Tae; Byun, Kwan Soo; Jung, Yong Jin; Tak, Won Young; Jeong, Sook-Hyang; Kwon, Kyung Min; Suri, Vithika; Wu, Peiwen; Jang, Byoung Kuk; Lee, Byung Seok; Cho, Ju-Yeon; Jang, Jeong Won; Yang, Soo Hyun; Paik, Seung Woon; Kim, Hyung Joon; Kwon, Jung Hyun; Park, Neung Hwa; Kim, Ju Hyun; Kim, In Hee; Ahn, Sang Hoon; Lim, Young-Suk | Pusan Natl Univ, Coll Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Liver Res Inst, Seoul, South Korea; Dong A Univ, Dong A Univ Hosp, Coll Med, Dept Internal Med, Busan, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Dept Internal Med, Busan, South Korea; Pusan Natl Univ, Sch Med, Yangsan Hosp, Dept Internal Med, Yangsan, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Gastroenterol & Hepatol, Seoul, South Korea; Seoul Natl Univ, Coll Med, Boramae Med Ctr, Div Gastroenterol,Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA; Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Chungnam Natl Univ, Sch Med, Dept Internal Med, Daejeon, South Korea; Chosun Univ, Coll Med, Dept Internal Med, Gwangju, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Hepatol, Seoul, South Korea; Vet Hlth Serv Med Ctr, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med, Seoul, South Korea; Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Internal Med, Ulsan, South Korea; Gachon Univ, Gil Med Ctr, Coll Med, Dept Internal Med, Incheon, South Korea; Jeonbuk Natl Univ Hosp, Dept Internal Med, Jeonju, South Korea; Yonsei Univ, Coll Med, Inst Gastroenterol, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol,Liver Ctr, Seoul, South Korea | Jeong, Sook-Hyang/J-5642-2012; Lim, Young-Suk/AFQ-5165-2022; Jang, Jeong/LOS-2890-2024; Lee, Yoon Jae/HGE-5712-2022; Kim, Yoon/J-2746-2012; 박, 진화/GYV-5685-2022; Heo, Jeong/MHQ-1390-2025; Ahn, Sang Hoon/AFM-2603-2022; Wu, Peiwen/IXX-1315-2023 | 8422238800; 25947520600; 34868280600; 24175940200; 14820137300; 57226086928; 56865094300; 7004074582; 7402425167; 58251252000; 57200392461; 57221164532; 58849853600; 57203247116; 57210595428; 7402965009; 57206925848; 7102643032; 57206212081; 39863073100; 7202111836; 57216524819; 7404143744; 7401989551; 57226548822 | AHNSH@yuhs.ac;limys@amc.seoul.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 38 | 4 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 2.2 | 28.1 | 0.49 | 2025-06-25 | 4 | 3 | Direct -acting antiviral; Decompensated cirrhosis; NS5A inhibitor; Polymerase inhibitor; Protease inhibitor | GENOTYPE 1; VIRUS-INFECTION; OPEN-LABEL; HCV; GS-9857; GUIDELINES | Decompensated cirrhosis; Direct-acting antiviral; NS5A inhibitor; Polymerase inhibitor; Protease inhibitor | alanine aminotransferase; aspartate aminotransferase; sofosbuvir plus velpatasvir; sofosbuvir plus velpatasvir plus voxilaprevir; virus RNA; adult; aged; alanine aminotransferase blood level; Article; aspartate aminotransferase blood level; clinical effectiveness; cohort analysis; drug efficacy; drug safety; drug tolerability; female; hepatitis C; Hepatitis C virus genotype 1; human; major clinical study; male; multicenter study; nonhuman; phase 3 clinical trial; South Korean; treatment outcome; treatment planning | English | 2023 | 2023-07 | 10.3904/kjim.2022.252 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Everyday rehearsal of death and the dilemmas of dying in super-ageing Japan | In recent years, a new trend of performing a 'good death' has swept Japanese society. Popular, especially among the elderly, shukatsu (sic) refers to the phenomenon of preparing for one's own demise through various practices, in particular, the writing of an 'ending note (sic)'. A will designates the beneficiaries of one's estate or property after one's passing, whereas an ending note not only includes financial and legal matters, it goes far beyond that. It contains provisions for the deceased-to-be's end-of-life treatments, such as hospice care, as well as explicit instructions for seemingly mundane details such as the guest list, flower arrangements, and casket for one's funeral. This trend of engaging in shukatsu can be viewed as a part of the biopolitics of a super-ageing Japanese society in which the elderly are now expected to manage all aspects of their own lives-including the disposal of their bodily remains when they pass away. Yet, as this anthropologically informed analysis discloses, such biopolitics also gives rise to a new set of ethical dilemmas for the elderly and their families, constituting a new form of politics of life and death. Indeed, rejecting the neoliberal injunction to efficiently separate death from life, many elderly try to recover-and resituate-death within the social and ethical realm of the living. | Kim, Heekyoung | Kyungpook Natl Univ, Dept Archaeol & Anthropol, Daegu, South Korea | 57474605400 | anthrohkkim@knu.ac.kr; | MODERN ASIAN STUDIES | MOD ASIAN STUD | 0026-749X | 1469-8099 | 57 | 1 | SSCI | AREA STUDIES | 2023 | 1 | 28.1 | 0 | 2025-06-25 | 1 | 1 | Death preparation; ending note; ageing; neoliberal biopolitics; Japan | HEALTH | ageing; Death preparation; ending note; Japan; neoliberal biopolitics | Japan; aging population; cultural geography; cultural influence; elderly population; ethics; mortality; neoliberalism | English | 2023 | 2023-01 | 10.1017/s0026749x21000445 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Helicobacter pylori eradication reduces risk for recurrence of gastric hyperplastic polyp after endoscopic resection | Background/Aims: Little is known about the effect of Helicobacter pylori eradication on the recurrence of gastric hyperplastic polyps after endoscopic resection. Thus, we evaluated the recurrence rate of gastric hyperplastic polyps based on H. pylori eradication following endoscopic resection. Methods: We retrospectively reviewed the medical records of 201 patients with H. pylori infection who underwent endoscopic resection for gastric hyperplastic polyps at six medical centers. H. pylori status was assessed by histological analysis and a rapid urease test. A total of 149 patients underwent successful H. pylori eradication (eradication group), whereas 52 patients had persistent H. pylori infections (non- eradication group). The recurrence rate of gastric hyperplastic polyps and the risk factors according to H. pylori status were analyzed. Results: During the mean follow-up period of 18.3 months, recurrent gastric polyps developed after endoscopic resection in 10 patients (19.2% [10/52]) in the non- eradication group and 12 patients (8.1% [12/149]) in the eradication group. The cumulative incidence of recurrent gastric hyperplastic polyps was significantly higher in the non- eradication group than in the eradication group (p = 0.041, log-rank test). In the adjusted analysis, H. pylori eradication reduced the recurrence of gastric hyperplastic polyps (hazard ratio [HR], 0.42; 95% confidence interval [CI], 0.18 to 0.99), whereas anticoagulation therapy increased the risk of recurrence of gastric hyperplastic polyps (HR, 4.91; 95% CI, 1.39 to 17.28). Conclusions: Successful eradication of H. pylori may reduce the recurrence of gastric hyperplastic polyps in patients after endoscopic mucosal resection. | Cho, Young Sin; Nam, Su Youn; Moon, Hee Seok; Kim, Tae Ho; Kim, Sung Eun; Jung, Jin Tae | Soonchunhyang Univ, Coll Med, Div Gastroenterol, Cheonan Hosp, Cheonan, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Ctr Gastr Canc, Sch Med, Daegu, South Korea; Chungnam Natl Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Coll Med, Daejeon, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Gastroenterol,Bucheon St Marys Hosp, Bucheon, South Korea; Kosin Univ, Dept Internal Med, Div Gastroenterol, Coll Med, Busan, South Korea; Daegu Catholic Univ, Dept Internal Med, Div Gastroenterol, Sch Med, Daegu, South Korea | Moon, Hee Seok/AAC-6951-2022; KIM, SUNG/ADF-8559-2022 | 57212979518; 55617028500; 35269308500; 57207802208; 58848142900; 7402896898 | nam20131114@gmail.com; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 38 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 2.2 | 28.1 | 0.82 | 2025-06-25 | 8 | 5 | Helicobacter pylori; Polyps; Endoscopic mucosal resection; Recurrence | MANAGEMENT; STOMACH; INFECTION | Endoscopic mucosal resection; Helicobacter pylori; Polyps; Recurrence | Adenomatous Polyps; Endoscopy; Helicobacter Infections; Helicobacter pylori; Humans; Retrospective Studies; Stomach Neoplasms; amoxicillin; anticoagulant agent; antithrombocytic agent; bismuth citrate; clarithromycin; hydroxymethylglutaryl coenzyme A reductase inhibitor; metronidazole; nonsteroid antiinflammatory agent; proton pump inhibitor; tetracycline; adult; anticoagulant therapy; Article; bacterial clearance; bacterium examination; confidence interval; controlled study; endoscopic mucosal resection; eradication therapy; female; follow up; gastric hyperplastic polyp; hazard ratio; Helicobacter infection; Helicobacter pylori; histopathology; human; human tissue; incidence; log rank test; major clinical study; male; medical record review; middle aged; nonhuman; recurrence risk; retrospective study; risk factor; risk reduction; stomach polyp; thrombosis; treatment outcome; triplet chemotherapy; adenomatous polyp; complication; endoscopy; Helicobacter infection; Helicobacter pylori; pathology; stomach tumor | English | 2023 | 2023-03 | 10.3904/kjim.2022.111 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Improved time-varying reproduction numbers using the generation interval for COVID-19 | Estimating key epidemiological parameters, such as incubation period, serial interval (SI), generation interval (GI) and latent period, is essential to quantify the transmissibility and effects of various interventions of COVID-19. These key parameters play a critical role in quantifying the basic reproduction number. With the hard work of epidemiological investigators in South Korea, estimating these key parameters has become possible based on infector-infectee surveillance data of COVID-19 between February 2020 and April 2021. Herein, the mean incubation period was estimated to be 4.9 days (95% CI: 4.2, 5.7) and the mean generation interval was estimated to be 4.3 days (95% CI: 4.2, 4.4). The mean serial interval was estimated to be 4.3, with a standard deviation of 4.2. It is also revealed that the proportion of presymptomatic transmission was similar to 57%, which indicates the potential risk of transmission before the disease onset. We compared the time-varying reproduction number based on GI and SI and found that the time-varying reproduction number based on GI may result in a larger estimation of R-t, which refers to the COVID-19 transmission potential around the rapid increase of cases. This highlights the importance of considering presymptomatic transmission and generation intervals when estimating the time-varying reproduction number. | Kim, Tobhin; Lee, Hyojung; Kim, Sungchan; Kim, Changhoon; Son, Hyunjin; Lee, Sunmi | Kyung Hee Univ, Dept Appl Math, Yongin, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Pusan Natl Univ, Coll Med, Dept Prevent Med, Busan, South Korea; Pusan Natl Univ Hosp, Busan Ctr Infect Dis Control & Prevent, Busan, South Korea; Dong A Univ, Coll Med, Dept Prevent Med, Busan, South Korea | 57550324000; 57196021198; 57193343289; 57203626040; 57203048631; 55716483800 | sunmilee@khu.ac.kr; | FRONTIERS IN PUBLIC HEALTH | FRONT PUBLIC HEALTH | 2296-2565 | 11 | SCIE;SSCI | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2023 | 3 | 28.1 | 1.14 | 2025-06-25 | 6 | 5 | COVID-19; latent period; generation interval; incubation period; serial interval; presymptomatic transmission | DYNAMICS | COVID-19; generation interval; incubation period; latent period; presymptomatic transmission; serial interval | Basic Reproduction Number; COVID-19; Humans; Reproduction; Republic of Korea; SARS-CoV-2; basic reproduction number; coronavirus disease 2019; epidemiology; human; reproduction; Severe acute respiratory syndrome coronavirus 2; South Korea | English | 2023 | 2023-06-30 | 10.3389/fpubh.2023.1185854 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Korean guidelines for the management of gout | Gout is the most common form of arthritis, with the prevalence increasing worldwide. The present treatment guidelines provide recommendations for the appropriate treatment of acute gout, management during the inter-critical period, and prevention of chronic complications. The guidelines were developed based on evidence- based medicine and draft recommendations finalized after expert consensus. These guidelines are designed to provide clinicians with clinical evidence to enable efficient treatment of gout. | Lee, Jennifer Jooha; Lee, Ji Soo; Chung, Min Kyung; Ahn, Joong Kyong; Choi, Hyo-Jin; Hong, Seung-Jae; Yoon, Chong-Hyeon; Kim, Su-Hyun; Jeong, Kyung-Hwan; Kim, Jong-Woo; Kim, Bo-Yeon; Shin, Jin-Ho; Kim, Woo Gyu; Kim, Soo-Young; Kim, Hyun-Jung; Song, Jeong-Soo; Jun, Jae-Bum; Park, Hyun-Ah; Chae, Shung Chull; Choi, Bum Soon; Kim, Tae Nyun; Kim, Hyun Ah | Catholic Univ Korea, Coll Med, Dept Internal Med, Div Rheumatol, Seoul, South Korea; Ewha Womans Univ, Dept Internal Med, Div Rheumatol, Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Rheumatol,Sch Med, Seoul, South Korea; Gachon Univ, Gil Med Ctr, Dept Internal Med, Div Rheumatol,Coll Med, Incheon, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp, Sch Med, Div Rheumatol,Dept Internal Med, Seoul, South Korea; Chung Ang Univ, Dept Internal Med, Div Nephrol, Sch Med, Seoul, South Korea; Kyung Hee Univ, Dept Internal Med, Div Nephrol, Med Ctr, Seoul, South Korea; Inje Univ, Sanggye Paik Hosp, Dept Family Med, Coll Med, Seoul, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab,Bucheon Hosp, Bucheon, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Div Cardiol, Seoul, South Korea; Lights & Salt Internal Med, Goyang, South Korea; Hallym Univ, Kangdong Sacred Heart Hosp, Dept Family Med, Coll Med, Seoul, South Korea; Korea Univ, Inst Evidence Based Med, Dept Prevent Med, Cochrane Korea,Coll Med, Seoul, South Korea; Chung Ang Univ, Dept Internal Med, Div Rheumatol, Sch Med, Seoul, South Korea; Hanyang Univ Hosp Rheumat Dis, Dept Rheumatol, Seoul, South Korea; Inje Univ, Seoul Paik Hosp, Dept Family Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Nephrol, Seoul, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Internal Med, Div Endocrinol & Metab,Coll Med, Busan, South Korea; Hallym Univ, Dept Internal Med, Div Rheumatol, Sacred Heart Hosp, Anyang, South Korea | Kim, Tae/AAV-5521-2020; Hyun-Jung, Kim/E-8074-2011; Kim, Soo Young/GLR-4223-2022; Kim, Su Hyun/JPY-2079-2023 | 53984609600; 14424388700; 56151890500; 23026979900; 7404338827; 9745284000; 7202882922; 57196229394; 8443579300; 48061224600; 56942628400; 57222486697; 58568401100; 56557998600; 56703907300; 58568414000; 7202753064; 13405439400; 7101962036; 7402755304; 36010711100; 57191721097 | kimha@hallym.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 38 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 2.2 | 28.1 | 0.33 | 2025-06-25 | 0 | 2 | Gout; Guidelines; Treatment | URATE-LOWERING THERAPY; SERUM URIC-ACID; DOUBLE-BLIND; FLARE PREVENTION; INITIATION; ALLOPURINOL; FEBUXOSTAT; COLCHICINE; RISK; PROPHYLAXIS | Gout; Guidelines; Treatment | Arthritis, Gouty; Asian People; Consensus; Gout; Humans; Republic of Korea; Article; evidence based medicine; gout; medical literature; practice guideline; publication; Asian; consensus; gout; human; South Korea | English | 2023 | 2023-09 | 10.3904/kjim.2023.206 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Long-term cardiovascular events in hypertensive patients: full report of the Korean Hypertension Cohort | Background/Aims: This study evaluated the long-term cardiovascular complications among Korean patients with hyperten-sion and compared them with that of controls without hypertension. Methods: The Korean Hypertension Cohort (KHC) enrolled 11,043 patients with hypertension and followed them for more than 10 years. Age-and sex-matched controls without hypertension were enrolled at a 1:10 ratio. We compared the inci-dence of cardiovascular events and death among patients and controls without hypertension. Results: The mean age was 59 years, and 34.8% and 16.5% of the patients belonged to the high and moderate cardiovas-cular risk groups, respectively. During the 10-year follow-up, 1,591 cardiovascular events (14.4%) with 588 deaths (5.3%) oc-curred among patients with hypertension and 7,635 cardiovascular events (6.9%) with 4,826 deaths (4.4%) occurred among controls. Even the low-risk population with hypertension showed a higher cardiovascular event rate than the population without hypertension. Although blood pressure measurements in the clinic showed remarkable inaccuracy compared with those measured in the national health examinations, systolic blood pressure (SBP) >= 150 mmHg was significantly associated with a higher risk of cardiovascular events. Conclusions: This long-term follow-up study confirmed the cardiovascular event rates among Korean hypertensive patients were substantial, reaching 15% in 10 years. SBP levels >= 150 mmHg were highly associated with occurrence of cardiovascular event rates. | Lee, Jin Young; Bak, Jean Kyung; Kim, Mina; Shin, Ho-Gyun; Park, Kyun-Ik; Lee, Seung-Pyo; Lee, Hee-Sun; Lee, Ju-Yeun; Kim, Kwang-il; Kang, Si-Hyuck; Lee, Jang Hoon; Jang, Se Yong; Lee, Ju-Hee; Kim, Kye Hun; Cho, Jae Yeong; Park, Jae-Hyeong; Park, Sue K.; Lee, Hae-Young | Chung Ang Univ, Dept Appl Stat, Seoul, South Korea; Natl Evidence Based Healthcare Collaborating Agcy, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Coll Pharm, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Dept Internal Med, Div Cardiol,Coll Med, Cheongju, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Dept Cardiovasc Med, Med Sch, Gwangju, South Korea; Chungnam Natl Univ, Dept Internal Med, Coll Med, Daejeon, South Korea; Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul, South Korea | Park, Jae-Hyeong/AAD-9015-2021; Lee, Hye-Young/JEP-8044-2023; Kang, Si-Hyuck/AAR-9790-2020; Cho, Jae Yeong/GVT-2986-2022; LEE, Seung/ISA-9627-2023; Kim, Kwang-il/AAP-7315-2021 | 57226402698; 57277449200; 57792673200; 57219900089; 57277120600; 55665415400; 55548996000; 55922427400; 57193847032; 35740757100; 54581258000; 57207977889; 57204073070; 56150430800; 59625559100; 36063048400; 8085325400; 56151235500 | hylee612@snu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 38 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 2.2 | 28.1 | 1.15 | 2025-06-25 | 5 | 7 | Hypertension; Blood pressure; Cardiovascular diseases | ACHIEVED BLOOD-PRESSURE; RISK; DISEASE; ASSOCIATION; OUTCOMES; TARGETS; ASIA | Blood pressure; Cardiovascular diseases; Hypertension | Blood Pressure; Cardiovascular Diseases; Follow-Up Studies; Humans; Hypertension; Middle Aged; Republic of Korea; Risk Factors; acetylsalicylic acid; aldosterone antagonist; alpha adrenergic receptor blocking agent; angiotensin receptor antagonist; antidiabetic agent; beta adrenergic receptor blocking agent; calcium channel blocking agent; dipeptidyl carboxypeptidase inhibitor; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitor; low density lipoprotein cholesterol; thiazide diuretic agent; triacylglycerol; adult; aged; albuminuria; all cause mortality; Article; blood pressure; blood pressure measurement; body mass; brain hemorrhage; cardiovascular disease; cardiovascular mortality; cardiovascular risk; cholesterol blood level; cohort analysis; controlled study; diabetes mellitus; diastolic blood pressure; end stage renal disease; estimated glomerular filtration rate; family history; female; follow up; heart failure; heart infarction; human; hypertension; hypertensive patient; incidence; ischemic stroke; Korean (people); major clinical study; male; metabolic syndrome X; mortality; national health insurance; peripheral arterial disease; risk reduction; smoking; systolic blood pressure; cardiovascular disease; hypertension; middle aged; risk factor; South Korea | English | 2023 | 2023-01 | 10.3904/kjim.2022.249 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Mechanisms influencing the factors of urban built environments and coronavirus disease 2019 at macroscopic and microscopic scales: The role of cities | In late 2019, the coronavirus disease 2019 (COVID-19) pandemic soundlessly slinked in and swept the world, exerting a tremendous impact on lifestyles. This study investigated changes in the infection rates of COVID-19 and the urban built environment in 45 areas in Manhattan, New York, and the relationship between the factors of the urban built environment and COVID-19. COVID-19 was used as the outcome variable, which represents the situation under normal conditions vs. non-pharmacological intervention (NPI), to analyze the macroscopic (macro) and microscopic (micro) factors of the urban built environment. Computer vision was introduced to quantify the material space of urban places from street-level panoramic images of the urban streetscape. The study then extracted the microscopic factors of the urban built environment. The micro factors were composed of two parts. The first was the urban level, which was composed of urban buildings, Panoramic View Green View Index, roads, the sky, and buildings (walls). The second was the streets' green structure, which consisted of macrophanerophyte, bush, and grass. The macro factors comprised population density, traffic, and points of interest. This study analyzed correlations from multiple levels using linear regression models. It also effectively explored the relationship between the urban built environment and COVID-19 transmission and the mechanism of its influence from multiple perspectives. | Zhang, Longhao; Han, Xin; Wu, Jun; Wang, Lei | Tianjin Chengjian Univ, Sch Architecture, Tianjin, Peoples R China; Kyungpook Natl Univ, Dept Landscape Architecture, Daegu, South Korea; Tianjin Univ, Sch Architecture, Tianjin, Peoples R China | ; Wu, Jun/JQW-9046-2023; 磊, 王/KFS-1412-2024 | 58437360700; 57716224500; 57222741708; 57715975800 | wujuntj@tcu.edu.cn;wanglei2021@tju.edu.cn; | FRONTIERS IN PUBLIC HEALTH | FRONT PUBLIC HEALTH | 2296-2565 | 11 | SCIE;SSCI | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2023 | 3 | 28.1 | 2.27 | 2025-06-25 | 8 | 10 | COVID-19; urban built environment; relevance; street view images; computer vision; deep learning | CLINICAL CHARACTERISTICS; LEVEL | computer vision; COVID-19; deep learning; relevance; street view images; urban built environment | Built Environment; Cities; COVID-19; Environment Design; Humans; Linear Models; city; environmental planning; epidemiology; human; statistical model | English | 2023 | 2023-02-28 | 10.3389/fpubh.2023.1137489 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Physiological Properties, Functions, and Trends in the Matrix Metalloproteinase Inhibitors in Inflammation-Mediated Human Diseases | Background Matrix metalloproteinases (MMPs), also known as metalloproteinases, are enzymes that degrade proteins and require the presence of active metal atoms. There are more than 20 types of MMPs, and they promote cell migration through the proteolytic degradation of the extracellular basement. MMPs are upregulated in cancers and inflamed regions. MMPs have three conservation regions: pro-MMP, catalysis, and hemopexin. Through these domains, MMPs cleave matrixes and cell-cell barriers. Consequently, MMPs cleave the whole extracellular matrix (ECM). In other words, they decompose most of the components related to the ECM, in their roles as key enzymes in cellular and pathophysiological events in the body. Introduction Zn2+-containing endo-type peptidases directly degrade and remodel the ECM region in the progression of various diseases. MMPs are frequently found in abnormal disease status of inflammatory responses, periodontal lesion, inflammatory pulmonary lesion, arteriosclerotic smooth muscles, arthritis, and tumor metastasis and invasion. They are also known to participate in aging processes-such as wrinkle formation-by destroying collagen in the dermis. In particular, the onset of diseases via the MMP-dependent inflammatory response is caused by the breakdown of proteins in the ECM and the basement membranous region, which are the supporting structures of cells. Methods This review describes the developments in the research examining the general and selective inhibitors for MMP associated with various human diseases over the past 20 years in terms of structure remodeling, substrate-recognizing specificities, and pharmacological applicability. Results Among two similar types of MMPs, MMP-2 is known as gelatinase-A with a 72 kDa, while MMP-9 is termed gelatinase-B with a 92 kDa. Both of these play a key role in this action. Therefore, both enzymatic expression levels coincide during the onset and progression of diseases. Endogenous tissue inhibitors of matrix metalloproteinases (TIMPs) are highly specific for each MMP inhibitor type. The intrinsic factors regulate various MMP types by inhibiting the onset of various diseases mediated by MMP-dependent or independent inflammatory responses. The MMP-9 and MMP-2 enzyme activity related to the prognosis of diseases associated with the inflammatory response are selectively inhibited by TIMP1 and TIMP2, respectively. The major pathogenesis of MMP-mediated diseases is related to the proliferation of inflammatory cells in various human tissues, which indicates their potential to diagnose or treat these diseases. The discovery of a substance that inhibits MMPs would be very important for preventing and treating various MMP-dependent diseases. Conclusion Considerable research has examined MMP inhibitors, but most of these have been synthetic compounds. Research using natural products as MMP inhibitors has only recently become a subject of interest. This review intends to discuss recent research trends regarding the physiological properties, functions, and therapeutic agents related to MMPs. | Kim, Il-Sup; Yang, Woong-Suk; Kim, Cheorl-Ho | Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu 41566, South Korea; Nodaji Co Ltd, Pohang 37927, Gyeongsangbuk D, South Korea; SungKyunKwan Univ, Dept Biol Sci, Mol & Cellular Glycobiol Unit, Suwon 16419, Gyunggi Do, South Korea; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Seoul 06351, South Korea | Kim, Cheorl-Ho/T-6753-2019 | 55477678200; 57069270500; 7409877266 | yangws91@naver.com;chkimbio@skku.edu;yang-ws91@naver.com; | CURRENT MEDICINAL CHEMISTRY | CURR MED CHEM | 0929-8673 | 1875-533X | 30 | 18 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY | 2023 | 3.5 | 28.1 | 1.53 | 2025-06-25 | 27 | 27 | Matrix metalloproteinases (MMP); MMP-9; MMP-mediated pathogenesis; inflammation; MMP inhibitors; ECM region | ENDOTHELIAL GROWTH-FACTOR; GELATINASE B SECRETION; STRUCTURE-BASED DESIGN; CELL-MIGRATION; EXTRACELLULAR-MATRIX; MOLECULAR-MECHANISM; CATALYTIC DOMAIN; CYSTEINE SWITCH; GENE-EXPRESSION; HIGHLY POTENT | ECM region; inflammation; Matrix metalloproteinases (MMP); MMP inhibi-tors; MMP-9; MMP-mediated pathogenesis | Extracellular Matrix; Gelatinases; Humans; Inflammation; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasms; ADAM protein; collagen; collagenase; collagenase 3; fibronectin; gelatinase; gelatinase A; gelatinase B; intrinsic factor; matrilysin; matrix metalloproteinase inhibitor; membrane metalloendopeptidase; monoclonal antibody; natural product; proteinase; scleroprotein; stromelysin; tissue inhibitor of metalloproteinase; vasculotropin; zinc ion; gelatinase; gelatinase A; matrix metalloproteinase inhibitor; allosterism; arteriosclerosis; arthritis; basement membrane; cancer inhibition; cell migration; cell proliferation; crystal structure; dermis; diabetes mellitus; disease exacerbation; drug selectivity; drug targeting; enzymatic degradation; enzyme activation; enzyme inhibition; enzyme substrate complex; extracellular matrix; gene expression regulation; human; inflammation; inflammatory cell; lung lesion; metastasis; nonhuman; pathogenesis; pathophysiology; periodontal disease; prognosis; protein domain; protein expression level; Review; smooth muscle; tumor invasion; upregulation; VEGF signaling; wrinkle; inflammation; metabolism; neoplasm | English | 2023 | 2023 | 10.2174/0929867329666220823112731 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Predictive role of absolute lymphocyte count in daratumumab-treated patients with relapsed/ refractory multiple myeloma | Background/Aims: Daratumumab has shown an encouraging antitumor effect in patients with multiple myeloma (MM), and was known to alter the immune properties by off-targeting immunosuppressive cells. Here, we aimed to evaluate the change in absolute lymphocyte count (ALC) as a surrogate marker for predicting survival outcomes of patients treated with daratumumab. Methods: Between 2018 and 2021, the medical records of patients with relapsed/refractory MM (RRMM) treated with daratumumab monotherapy at 10 centers in South Korea were reviewed. We collected the ALC data at pre-infusion (D0), day 2 after the first infusion (D2), and prior to the third cycle of daratumumab therapy (D56) Results: Fifty patients who were administered at least two cycles of daratumumab were included. Overall response rate was 54.0% after two cycles of daratumumab treatment. On D2, almost all patients experienced a marked reduction in ALC. However, an increase in ALC on D56 (ALCD56) was observed in patients with non-progressive disease, whereas failure of ALC recovery was noted in those with progressive disease. Patients with ALCD56 > 700/mu L (n = 39, 78.0%) had prolonged progression-free survival (PFS) and overall survival (OS) than those with ALCD56 = 700/mu L (median PFS: 5.8 months vs. 2.6 months, p = 0.025; median OS: 24.1 months vs. 6.1 months, p = 0.004). In addition, ALCD56 > 700/mu L was a significant favorable prognostic factor for PFS (hazard ratio [HR], 0.22; p = 0.003) and OS (HR, 0.23; p = 0.012). Conclusions: Increase in ALC during daratumumab treatment was significantly associated with prolonged survival outcomes in patients with RRMM. The ALC value can predict clinical outcomes in patients treated with daratumumab. | Cho, Hee Jeong; Jo, Jae-Cheol; Lee, Yoo Jin; Lee, Myung Won; Kim, Do Young; Shin, Ho Jin; Im, Sung Nam; Lee, Ji Hyun; Bae, Sung Hwa; Do, Young Rok; Lee, Won Sik; Kim, Min Kyung; Jung, Jina; Lee, Jung Min; Kim, Ju-Hyung; Baek, Dong Won; Sohn, Sang-Kyun; Moon, Joon Ho | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, 130 Dongdeok Ro, Daegu 41944, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Hematol & Oncol, Coll Med, Ulsan, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Hematol Oncol, Coll Med, Daejeon, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Hematol Oncol, Sch Med, Busan, South Korea; Inje Univ, Dept Hematol Oncol, Haeundae Paik Hosp, Busan, South Korea; Dong A Univ Hosp, Dept Hematol Oncol, Busan, South Korea; Daegu Catholic Univ, Daegu Catholic Univ Hosp, Dept Hematol Oncol, Sch Med, Daegu, South Korea; Keimyung Univ, Dept Hematol Oncol, Sch Med, Daegu, South Korea; Inje Univ, Dept Hematol Oncol, Busan Paik Hosp, Busan, South Korea; Yeungnam Univ Hosp, Dept Hematol Oncol, Daegu, South Korea | Lee, Yoojin/AAB-9799-2022; Lee, Jung-Min/L-8227-2016; Jo, Jae-Cheol/CAE-9453-2022; Hyun-Jung, Kim/E-8074-2011 | 57216754907; 35818309200; 57188669696; 55890002700; 57206099586; 16239868400; 57191922511; 56813113800; 56545017400; 8960168300; 55556573100; 58914633600; 58128627500; 57211561890; 58739544500; 57191874272; 13310226800; 56568642700 | jhmoon@knu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 38 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 2.2 | 28.1 | 0.16 | 2025-06-25 | 3 | 1 | Multiple myeloma; Daratumumab; Lymphocyte count; Biomarkers; Survival analysis | SURVIVAL; MONOTHERAPY; CELLS; CRITERIA; THERAPY; IMPACT; RISK; CD38 | Biomarkers; Daratumumab; Lymphocyte count; Multiple myeloma; Survival analysis | Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Humans; Lymphocyte Count; Multiple Myeloma; Progression-Free Survival; daratumumab; antineoplastic agent; daratumumab; monoclonal antibody; absolute lymphocyte count; adult; aged; Article; cancer growth; cancer staging; cancer survival; clinical article; clinical outcome; controlled study; female; general pathological parameters; human; human cell; low risk patient; male; monotherapy; mortality risk; multiple cycle treatment; multiple myeloma; overall response rate; overall survival; prediction; prognostic factor; progression free survival; refractory multiple myeloma; refractory multiple myeloma; relapsed multiple myeloma; relapsed multiple myeloma; retrospective study; South Korea; treatment response; lymphocyte count; multiple myeloma; pathology | English | 2023 | 2023-03 | 10.3904/kjim.2022.183 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Correction | Predictive role of absolute lymphocyte count in daratumumab-treated patients with relapsed/refractory multiple myeloma (vol 38, pg 238, 2023) | Cho, Hee Jeong; Jo, Jae-Cheol; Lee, Yoo Jin; Lee, Myung Won; Kim, Do Young; Shin, Ho Jin; Im, Sung Nam; Lee, Ji Hyun; Bae, Sung Hwa; Do, Young Rok; Lee, Won Sik; Kim, Min Kyung; Jung, Jina; Lee, Jung Min; Kim, Ju-Hyung; Baek, Dong Won; Sohn, Sang-Kyun; Moon, Joon Ho | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Univ Ulsan, Ulsan Univ Hosp, Dept Hematol & Oncol, Coll Med, Ulsan, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Dept Hematol Oncol, Coll Med, Daejeon, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Hematol Oncol, Sch Med, Busan, South Korea; Inje Univ, Dept Hematol Oncol, Haeundae Paik Hosp, Busan, South Korea; Dong A Univ Hosp, Dept Hematol Oncol, Busan, South Korea; Daegu Catholic Univ, Daegu Catholic Univ Hosp, Dept Hematol Oncol, Sch Med, Daegu, South Korea; Keimyung Univ, Dept Hematol Oncol, Sch Med, Daegu, South Korea; Inje Univ, Dept Hematol Oncol, Busan Paik Hosp, Busan, South Korea; Yeungnam Univ Hosp, Dept Hematol Oncol, Daegu, South Korea | Lee, Yoojin/AAB-9799-2022; Jo, Jae-Cheol/CAE-9453-2022; Hyun-Jung, Kim/E-8074-2011; Lee, Jung-Min/L-8227-2016 | 57216754907; 35818309200; 57188669696; 55890002700; 57206099586; 16239868400; 57191922511; 56813113800; 56545017400; 8960168300; 55556573100; 58914633600; 58128627500; 57211561890; 58739544500; 57191874272; 13310226800; 56568642700 | jhmoon@knu.ac.kr; | KOREAN JOURNAL OF INTERNAL MEDICINE | KOREAN J INTERN MED | 1226-3303 | 2005-6648 | 38 | 4 | SCIE | MEDICINE, GENERAL & INTERNAL | 2023 | 2.2 | 28.1 | 0 | 2025-06-25 | 0 | 0 | erratum | English | 2023 | 2023-07 | 10.3904/kjim.2022.183e | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Restorative perception of urban streets: Interpretation using deep learning and MGWR models | Restorative environments help people recover from mental fatigue and negative emotional and physical reactions to stress. Excellent restorative environments in urban streets help people focus and improve their daily behavioral performance, allowing them to regain efficient information processing skills and cognitive levels. High-density urban spaces create obstacles in resident interactions with the natural environment. For urban residents, the restorative function of the urban space is more important than that of the natural environment in the suburbs. An urban street is a spatial carrier used by residents on a daily basis; thus, the urban street has considerable practical value in terms of improving the urban environment to have effective restorative function. Thus, in this study, we explored a method to determine the perceived restorability of urban streets using street view data, deep learning models, and the Ordinary Least Squares (OLS), the multiscale geographically weighted regression (MGWR) model. We performed an empirical study in the Nanshan District of Shenzhen, China. Nanshan District is a typical high-density city area in China with a large population and limited urban resources. Using the street view images of the study area, a deep learning scoring model was developed, the SegNet algorithm was introduced to segment and classify the visual street elements, and a random forest algorithm based on the restorative factor scale was employed to evaluate the restorative perception of urban streets. In this study, spatial heterogeneity could be observed in the restorative perception data, and the MGWR models yielded higher R-2 interpretation strength in terms of processing the urban street restorative data compared to the ordinary least squares and geographically weighted regression (GWR) models. The MGWR model is a regression model that uses different bandwidths for different visual street elements, thereby allowing additional detailed observation of the extent and relevance of the impact of different elements on restorative perception. Our research also supports the exploration of the size of areas where heterogeneity exists in space for each visual street element. We believe that our results can help develop informed design guidelines to enhance street restorative and help professionals develop targeted design improvement concepts based on the restorative nature of the urban street. | Han, Xin; Wang, Lei; He, Jie; Jung, Taeyeol | Kyungpook Natl Univ, Dept Landscape Architecture, Daegu, South Korea; Tianjin Univ, Sch Architecture, Tianjin, Peoples R China; Harbin Inst Technol, Sch Architecture, Shenzhen, Peoples R China | ; 磊, 王/KFS-1412-2024 | 57716224500; 57715975800; 57221314854; 55490551100 | hejie2021@hit.edu.cn;jungty@knu.ac.kr; | FRONTIERS IN PUBLIC HEALTH | FRONT PUBLIC HEALTH | 2296-2565 | 11 | SCIE;SSCI | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2023 | 3 | 28.1 | 3.86 | 2025-06-25 | 18 | 17 | deep learning; street view; semantic segmentation; multiscale geographically weighted regression; urban street environment; restorative quality | GEOGRAPHICALLY WEIGHTED REGRESSION; STRESS RECOVERY | deep learning; multiscale geographically weighted regression; restorative quality; semantic segmentation; street view; urban street environment | Cities; Deep Learning; Environment; Humans; Perception; Spatial Regression; city; environment; human; perception; spatial regression | English | 2023 | 2023-03-30 | 10.3389/fpubh.2023.1141630 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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