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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Care for critically and terminally ill patients and moral distress of physicians and nurses in tertiary hospitals in South Korea: A qualitative study | Physicians and nurses working in acute care settings, such as tertiary hospitals, are involved in various stages of critical and terminal care, ranging from diagnosis of life-threatening diseases to care for the dying. It is well known that critical and terminal care causes moral distress to healthcare professionals. This study aimed to explore moral distress in critical and terminal care in acute hospital settings by analyzing the experiences of physicians and nurses from various departments. Semi-structured in-depth interviews were conducted in two tertiary hospitals in South Korea. The collected data were analyzed using grounded theory. A total of 22 physicians and nurses who had experienced moral difficulties regarding critical and terminal care were recruited via purposive maximum variation sampling, and 21 reported moral distress. The following points were what participants believed to be right for the patients: minimizing meaningless interventions during the terminal stage, letting patients know of their poor prognosis, saving lives, offering palliative care, and providing care with compassion. However, family dominance, hierarchy, the clinical culture of avoiding the discussion of death, lack of support for the surviving patients, and intensive workload challenged what the participants were pursuing and frustrated them. As a result, the participants experienced stress, lack of enthusiasm, guilt, depression, and skepticism. This study revealed that healthcare professionals working in tertiary hospitals in South Korea experienced moral distress when taking care of critically and terminally ill patients, in similar ways to the medical staff working in other settings. On the other hand, the present study uniquely identified that the aspects of saving lives and the necessity of palliative care were reported as those valued by healthcare professionals. This study contributes to the literature by adding data collected from two tertiary hospitals in South Korea. | Kang, Jiyeon; Choi, Eun Kyung; Seo, Minjeong; Ahn, Grace S.; Park, Hye Youn; Hong, Jinui; Kim, Min Sun; Keam, Bhumsuk; Park, Hye Yoon | Seoul Natl Univ, Dept Anthropol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Med Educ Ctr, Daegu, South Korea; Gyeongsang Natl Univ, Coll Nursing, Jinju, Gyeongsangnamdo, South Korea; Gyeongsang Natl Univ, Gerontol Hlth Res Ctr Inst Hlth Sci, Jinju, Gyeongsangnamdo, South Korea; Univ Calif San Diego, Sch Med, La Jolla, CA USA; Seoul Natl Univ, Dept Neuropsychiatry, Bundang Hosp, Seoul, South Korea; Seoul Natl Univ Hosp, Ctr Palliat Care & Clin Ethics, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Pediat, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Psychiat, Seoul, South Korea; Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea | ; Kang, Jiyeon/KHV-4892-2024; choi, eunkyung/JUF-8150-2023; Kim, Seonghwan/AAZ-1679-2021 | 57217126239; 57391706800; 57191039621; 57204606941; 55794207700; 57218180864; 55568531722; 14028521700; 57189505933 | psychepark@gmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 12 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0.49 | 2025-07-30 | 10 | 10 | OF-LIFE CARE; NURSING-CARE; END; STAFF; CHALLENGES; FAMILIES; CULTURE; ISSUES; VIEWS | Adult; Critical Care; Female; Humans; Interviews as Topic; Male; Middle Aged; Nursing Staff, Hospital; Physicians; Prognosis; Republic of Korea; Stress, Psychological; Surveys and Questionnaires; Terminally Ill; Tertiary Care Centers; Young Adult; adult; Article; critically ill patient; doctor nurse relation; dominance behavior; ethical dilemma; female; grounded theory; human; male; medical staff; nurse attitude; palliative therapy; physician attitude; prognosis; qualitative research; South Korea; terminal care; terminally ill patient; tertiary care center; workload; intensive care; interview; mental stress; middle aged; nursing staff; physician; psychology; questionnaire; young adult | English | 2021 | 2021-12-16 | 10.1371/journal.pone.0260343 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | COVID-19 pneumonia on chest X-rays: Performance of a deep learning-based computer-aided detection system | Chest X-rays (CXRs) can help triage for Coronavirus disease (COVID-19) patients in resource-constrained environments, and a computer-aided detection system (CAD) that can identify pneumonia on CXR may help the triage of patients in those environment where expert radiologists are not available. However, the performance of existing CAD for identifying COVID-19 and associated pneumonia on CXRs has been scarcely investigated. In this study, CXRs of patients with and without COVID-19 confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) were retrospectively collected from four and one institution, respectively, and a commercialized, regulatory-approved CAD that can identify various abnormalities including pneumonia was used to analyze each CXR. Performance of the CAD was evaluated using area under the receiver operating characteristic curves (AUCs), with reference standards of the RT-PCR results and the presence of findings of pneumonia on chest CTs obtained within 24 hours from the CXR. For comparison, 5 thoracic radiologists and 5 non-radiologist physicians independently interpreted the CXRs. Afterward, they re-interpreted the CXRs with corresponding CAD results. The performance of CAD (AUCs, 0.714 and 0.790 against RT-PCR and chest CT, respectively hereinafter) were similar with those of thoracic radiologists (AUCs, 0.701 and 0.784), and higher than those of non-radiologist physicians (AUCs, 0.584 and 0.650). Non-radiologist physicians showed significantly improved performance when assisted with the CAD (AUCs, 0.584 to 0.664 and 0.650 to 0.738). In addition, inter-reader agreement among physicians was also improved in the CAD-assisted interpretation (Fleiss' kappa coefficient, 0.209 to 0.322). In conclusion, radiologist-level performance of the CAD in identifying COVID-19 and associated pneumonia on CXR and enhanced performance of non-radiologist physicians with the CAD assistance suggest that the CAD can support physicians in interpreting CXRs and helping image-based triage of COVID-19 patients in resource-constrained environment. | Hwang, Eui Jin; Kim, Ki Beom; Kim, Jin Young; Lim, Jae-Kwang; Nam, Ju Gang; Choi, Hyewon; Kim, Hyungjin; Yoon, Soon Ho; Goo, Jin Mo; Park, Chang Min | Seoul Natl Univ, Dept Radiol, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Radiol, Seoul, South Korea; Daegu Fatima Hosp, Dept Radiol, Daegu, South Korea; Keimyung Univ, Dept Radiol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Seoul Natl Univ, Inst Radiat Med, Med Res Ctr, Seoul, South Korea; Chung Ang Univ Hosp, Dept Radiol, Seoul, South Korea | ; Yoon, Soon/AAL-1640-2020; Kim, Hyungjin/JED-7172-2023; Park, Chang/J-8409-2016; Goo, Jin Mo/AFT-4543-2022; Kim, Juhee/KFS-3069-2024; Hwang, Eui/X-4415-2018 | 56018603700; 59080545400; 55862597800; 55515341400; 57201464949; 57193447585; 57207824165; 57219956574; 7006253916; 16234023200 | cmpark.morphius@gmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 1.46 | 2025-07-30 | 20 | 29 | CORONAVIRUS DISEASE 2019; WUHAN; CT | Aged; COVID-19; Deep Learning; Female; Humans; Lung; Male; Middle Aged; Radiographic Image Interpretation, Computer-Assisted; Radiography, Thoracic; Republic of Korea; Retrospective Studies; Tomography, X-Ray Computed; adult; aged; Article; computer assisted diagnosis; controlled study; coronavirus disease 2019; deep learning; female; human; major clinical study; male; receiver operating characteristic; retrospective study; sensitivity and specificity; thorax radiography; diagnostic imaging; epidemiology; lung; middle aged; pathology; South Korea; thorax radiography; x-ray computed tomography | English | 2021 | 2021-06-07 | 10.1371/journal.pone.0252440 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Diagnostic usefulness of the spot urine sodium/potassium ratio in cirrhotic patients with ascites | Background and aims The low-salt diet is considered important for control of ascites in cirrhotic patients. To validate whether the spot urine sodium (Na)/potassium (K) ratio could replace 24-h urine Na (uNa) excretion in assessing low-salt diet compliance. Methods We prospectively studied 175 patients. 24-h urine collection and spot urine collection were performed. Subsequently, 24-h uNa, urine creatinine (uCr), and spot urine Na and K were assessed. A complete urine collection was confirmed based on 24-h uCr excretion levels of 15mg/kg/day for men and 10mg/kg/day for women. The area under the receiver operating characteristic (AUROC) curve analysis was performed to evaluate the feasibility of spot urine Na/K ratio in predicting 24-h uNa greater than 78mmol/day. Results Out of 175 patients, 24-h urine samples were completely collected in 57 patients only. Moreover, urine samples were not completely collected in 118 patients because their 24-h uCr excretion level was less than the established criteria. In complete urine collection group, AUROC curve for spot urine Na/K ratio in predicting 24-h uNa greater than 78mmol/day was 0.874 +/- 0.051 (P<0.001). In the incomplete urine collection group, the AUROC was 0.832 +/- 0.039 (P<0.001). In complete urine collection group, the classical cutoff value greater than 1.0 of spot urine Na/K ratio showed 90.9% sensitivity and 56.0% specificity. Conclusions The spot urine Na/K ratio reflects 24-h uNa, but the AUROC value obtained in this study is lower than that of a previous study. Considered the large number of patients with incomplete urine collection, validating 24-h complete urine collection criteria is necessary. | Lee, Jin Wook; Hwang, Jae Seok; Chung, Woo Jin; Lee, Heon Ju; Park, Jung Gil; Lee, Chang Hyeong; Kim, Byung Seok; Song, Jeong Eun; Kweon, Young Oh; Tak, Won Young; Park, Soo Young; Jang, Se Young; Suh, Jeong Ill; Jang, Byoung Kuk | Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Bokwang Hosp, Dept Internal Med, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Dongguk Univ, Dept Internal Med, Coll Med, Gyeongju, South Korea | Lee, Hyo-Suk/J-5618-2012; Kim, Sang/J-5398-2012; Park, Jung/AAK-5167-2020; song, jeong/P-9106-2015 | 57224911284; 57205851488; 55741230500; 59105278500; 57216816399; 55784781600; 55974276800; 57189097150; 7004694832; 7004074582; 57191674344; 57202881977; 7201515001; 58849853600 | jangha106@gmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0 | 2025-07-30 | 0 | 0 | NATURAL-HISTORY; LIVER-CIRRHOSIS; SODIUM; SARCOPENIA; PARACENTESIS; EXCRETION; CARE | Adult; Ascites; Creatinine; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Patient Compliance; Potassium; ROC Curve; Sodium; creatinine; potassium; sodium; creatinine; potassium; sodium; adult; Article; ascites; creatinine urine level; diagnostic accuracy; diagnostic test accuracy study; dietary compliance; female; human; liver cirrhosis; major clinical study; male; middle aged; potassium urine level; prediction; prospective study; sensitivity and specificity; sodium excretion; sodium restriction; sodium urine level; urine sampling; ascites; complication; liver cirrhosis; pathology; patient compliance; receiver operating characteristic; urine | English | 2021 | 2021-06-24 | 10.1371/journal.pone.0253886 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Direct medical costs after surgical or nonsurgical treatment for degenerative lumbar spinal disease: A nationwide matched cohort study with a 10-year follow-up | Objective The demand for treating degenerative lumbar spinal disease has been increasing, leading to increased utilization of medical resources. Thus, we need to understand how the budget of insurance is currently used. The objective of the present study is to overview the utilization of the National Health Insurance Service (NHIS) by providing the direct insured cost between patients receiving surgery and patients receiving nonsurgical treatment for degenerative lumbar disease. Methods The NHIS-National Sample Cohort was utilized to select patients with lumbar disc herniation, spinal stenosis, spondylolisthesis or spondylolysis. A matched cohort study design was used to show direct medical costs of surgery (n = 2,698) and nonsurgical (n = 2,698) cohorts. Non-surgical treatment included medication, physiotherapy, injection, and chiropractic. The monthly costs of the surgery cohort and nonsurgical cohort were presented at initial treatment, posttreatment 1, 3, 6, 9, and 12 months and yearly thereafter for 10 years. Results The characteristics and matching factors were well-balanced between the matched cohorts. Overall, surgery cohort spent $50.84/patient/month, while the nonsurgical cohort spent $29.34/patient/month (p<0.01). Initially, surgery treatment led to more charge to NHIS ($2,762) than nonsurgical treatment ($180.4) (p<0.01). Compared with the non-surgical cohort, the surgery cohort charged $33/month more for the first 3 months, charged less at 12 months, and charged approximately the same over the course of 10 years. Conclusion Surgical treatment initially led to more government reimbursement than nonsurgical treatment, but the charges during follow-up period were not different. The results of the present study should be interpreted in light of the costs of medical services, indirect costs, societal cost, quality of life and societal willingness to pay in each country. The monetary figures are implied to be actual economic costs but those in the reimbursement system instead reflect reimbursement charges from the government. | Kim, Chi Heon; Chung, Chun Kee; Choi, Yunhee; Lee, Juhee; Yang, Seung Heon; Lee, Chang Hyun; Park, Sung Bae; Kim, Kyoung-Tae; Rhee, John M.; Park, Moon Soo | Seoul Natl Univ Hosp, Dept Neurosurg, Seoul, South Korea; Seoul Natl Univ, Dept Neurosurg, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Brain & Cognit Sci, Seoul, South Korea; Seoul Natl Univ Hosp, Med Res Collaborating Ctr, Div Med Stat, Seoul, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Neurosurg, Boramae Hosp, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Emory Univ, Dept Orthopaed Surg, Sch Med, Atlanta, GA 30322 USA; Hallym Univ, Dept Orthoped, Dongtan Sacred Heart Hosp, Gyeonggi, South Korea | Choi, You-Jung/AFR-4193-2022; Kim, Chi/J-6536-2019; PARK, MOON/AAQ-5767-2020 | 35145892000; 7403613043; 7404777879; 57204073070; 56440402100; 56942572100; 45261436700; 57201369790; 7202839338; 57224667717 | chungc@snu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 12 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0.54 | 2025-07-30 | 10 | 11 | LOW-BACK-PAIN; RESEARCH TRIAL SPORT; NONOPERATIVE TREATMENT; REOPERATION RATES; DISC HERNIATION; PRACTICE PATTERNS; HEALTH INSURANCE; FUSION SURGERY; OUTCOMES; SPONDYLOLISTHESIS | Adult; Aged; Analgesia; Cost of Illness; Exercise Therapy; Female; Humans; Intervertebral Disc Degeneration; Lumbosacral Region; Male; Manipulation, Chiropractic; Middle Aged; Orthopedic Procedures; Spinal Stenosis; Spondylolisthesis; Spondylolysis; adult; Article; chiropractic; cohort analysis; comparative study; conservative treatment; female; follow up; government; health care cost; human; lumbar disk hernia; lumbar spinal stenosis; major clinical study; male; middle aged; national health insurance; patient selection; physiotherapy; postoperative period; quality of life; spinal cord atrophy; spondylolisthesis; spondylolysis; Willingness To Pay; aged; analgesia; chiropractic manipulation; cost of illness; economics; intervertebral disk degeneration; kinesiotherapy; lumbosacral region; orthopedic surgery; pathology; vertebral canal stenosis | English | 2021 | 2021-12-01 | 10.1371/journal.pone.0260460 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | EphA2 promotes tumorigenicity of cervical cancer by up-regulating CDK6 | Erythropoietin-producing hepatocellular receptor A2 (EphA2) receptor tyrosine kinase plays an important role in tissue organization and homeostasis in normal organs. EphA2 is overexpressed in a variety of types of solid tumours with oncogenic functions. However, the role of EphA2 in cervical cancer (CC) is still needed to be further explored. Here, we examined the role of EphA2 by establishing a stable EphA2 knock-down CC cell lines or a stable EphA2-overexpressed CC cells lines. Overexpression of EphA2 increased cell proliferation and migration of CC while EphA2 knock-down decreased the CC tumorigenicity. In addition, EphA2 knock-down suppressed CC tumour development in the xenograft mouse model. Inhibition of EphA2 by AWL-II-41-27, EphA2-specific tyrosine kinase inhibitor, or knock-down of EphA2 decreased mRNA and protein expression of cyclin-dependent kinase (CDK) 6 in CC cells, which increased cellular susceptibility to epirubicin (EPI), an anti-cancer chemotherapy drug. A clinicopathological study of EphA2 was conducted on a cohort of 158 human CC patients. EphA2 protein expression was positively correlated with CDK6 protein expression, invasion depth, lymph node metastasis and clinicopathological stage (P < .05). This study demonstrates the oncogenic activity of EphA2 in vitro and in vivo, which provides insights into the relevant mechanisms that might lead to novel treatments for CC. | Huang, Changhao; Chen, Zihua; He, Yihong; He, Zhengxi; Ban, Zhenying; Zhu, Yuanhang; Ding, Leilei; Yang, Chen; Jeong, Ji-Hak; Yuan, Weijie; Yang, Li | Cent South Univ, Xiangya Hosp, Hunan Key Lab Precise Diag & Treatment Gastrointe, Changsha, Peoples R China; Cent South Univ, Xiangya Hosp, Dept Gastrointestinal Surg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China; Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha, Peoples R China; Zhengzhou Univ, Affiliated Hosp 3, Zhengzhou, Peoples R China; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea | ; zhang, yi/HKV-8165-2023; Huang, Changhao/LHA-6143-2024 | 57190050818; 23977374300; 57222014747; 57205163540; 56708282100; 57195683972; 57218528561; 57203149100; 55913671500; 56822842400; 57213065734 | csuxyywj@csu.edu.cn;zdsfyyangli@163.com; | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | J CELL MOL MED | 1582-1838 | 1582-4934 | 25 | 6 | SCIE | CELL BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2021 | 5.295 | 38.5 | 1.06 | 2025-07-30 | 16 | 17 | CDK6; cervical cancer; chemotherapy resistance; EphA2 | CDK6; cervical cancer; chemotherapy resistance; EphA2 | AWL II 41 27; cyclin dependent kinase 6; ephrin receptor A2; epidermal growth factor receptor; epirubicin; insulin; messenger RNA; unclassified drug; adult; angiogenesis; animal cell; animal model; animal tissue; antineoplastic activity; apoptosis; Article; C-4-I cell line; cancer chemotherapy; cancer staging; carcinogenicity; cell migration; cell proliferation; cell proliferation assay; cell viability; cohort analysis; controlled study; female; gene knockdown; gene mutation; gene overexpression; genetic transduction; genetic transfection; HeLa cell line; human; human cell; human tissue; immunohistochemistry; in vitro study; in vivo study; lymph node metastasis; major clinical study; middle aged; mouse; mRNA expression level; MTT assay; nonhuman; protein expression; real time reverse transcription polymerase chain reaction; SiHa cell line; transwell assay; upregulation; uterine cervix cancer; Western blotting; wound healing assay | English | 2021 | 2021-03 | 10.1111/jcmm.16337 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Identification of a novel non-invasive biological marker to overcome the shortcomings of PSA in diagnosis and risk stratification for prostate cancer: Initial prospective study of developmental endothelial locus-1 protein | Objective This prospective study sought to clarify the developmental endothelial locus-1 (Del-1) protein as values of diagnosis and risk stratification of prostate cancer (PCa). Design From February 2017 to December 2019, a total 458 patients who underwent transrectal ultrasound guided prostate biopsy or surgery of benign prostatic hyperplasia agreed to research of Del-1 protein. We prospectively compared and analyzed the Del-1 protein and prostate specific antigen (PSA) in relation to the patients' demographic and clinicopathological characteristics. Results Mean age was 68.868.55 years. Mean PSA and Del-1 protein was 21.72 +/- 89.37, 0.099 +/- 0.145, respectively. Two hundred seventy-six (60.3%) patients were diagnosed as PCa. Among them, 181 patients underwent radical prostatectomy (RP). There were significant differences in Del-1 protein between benign and PCa group (0.066 +/- 0.131 vs 0.121 +/- 0.149, respectively, p = 0.120) for predicting PCa were 88.9% (56/63) and 93.5% (101/108), respectively. Among 181 patients who underwent RP, there were significant differences in Del-1 protein according to stage (pT2 vs pT3a vs >= pT3b) (0.113 +/- 0.078, 0.171 +/- 0.121, 0.227 +/- 0.161, respectively, p = 9) were the independent prognostic factors for predicting higher pT stage (>= 3b). Furthermore, age, PSA and Del-1 protein were independent prognostic factors for predicting significant PCa. Conclusion Patients with PCa showed higher expression of Del-1 protein than benign patients. Del-1 protein increased with the stage and Gleason score of PCa. Collaboration with PSA, Del-1 protein can be a non-invasive useful marker for diagnosis and risk stratification of PCa. | Chung, Jae-Wook; Kim, Hyun Tae; Ha, Yun-Sok; Lee, Eun Hye; Chun, So Young; Lee, Chan-Hyeong; Byeon, Kyeong Hyeon; Choi, Seock Hwan; Lee, Jun Nyung; Kim, Bum Soo; Kim, Tae-Hwan; Yoo, Eun Sang; Yoon, Ghil Suk; Baek, Moon-Chang; Kwon, Tae Gyun | Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Kyungpook Natl Univ, Biomed Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu, South Korea | ; Kim, Tae/B-9921-2013; Kim, Young-Bo/AAR-8052-2021 | 35204798500; 55739531300; 35487226400; 57189661699; 8688166900; 57189904697; 57204423048; 9742645500; 16301364600; 57202817150; 57797823600; 7006609239; 57204691355; 7006013097; 15073765400 | mcbaek@knu.ac.kr;tgkwon@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 4 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0.43 | 2025-07-30 | 9 | 9 | BREAST-CANCER; CELL; EXOSOMES; ANTIGEN; ALPHA-V-BETA-3; EXPRESSION; BIOMARKERS; ADHESION; UTILITY; GROWTH | Aged; Biopsy; Calcium-Binding Proteins; Cell Adhesion Molecules; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Predictive Value of Tests; Prospective Studies; Prostate; Prostate-Specific Antigen; Prostatectomy; Prostatic Hyperplasia; Prostatic Neoplasms; Risk Assessment; developmental endothelial locus 1 protein; prostate specific antigen; tumor marker; unclassified drug; calcium binding protein; cell adhesion molecule; EDIL3 protein, human; prostate specific antigen; adult; age; aged; antigen specificity; Article; cancer diagnosis; cancer prognosis; cancer risk; cancer staging; cohort analysis; controlled study; diagnostic test accuracy study; disease association; Gleason score; human; human tissue; major clinical study; male; predictive value; prospective study; prostate biopsy; prostate cancer; prostate hypertrophy; prostatectomy; protein analysis; protein blood level; protein expression; sensitivity and specificity; transrectal ultrasound guided biopsy; biopsy; blood; cancer grading; lymph node metastasis; middle aged; pathology; prostate; prostate hypertrophy; prostate tumor; risk assessment | English | 2021 | 2021-04-26 | 10.1371/journal.pone.0250254 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Impact of acute kidney injury on graft outcomes of deceased donor kidney transplantation: A nationwide registry-based matched cohort study in Korea | Background Favorable long-term and short-term graft survival and patient survival after kidney transplantation (KT) from deceased donors with acute kidney injury (AKI) have been reported. However, few studies have evaluated effects of donor AKI status on graft outcomes after KT in Asian population. Thus, the purpose of this study was to evaluate graft function after KTs from donors with AKI compared to matched KTs from donors without AKI using a multicenter cohort in Korea. Methods We analyzed a total of 1,466 KTs collected in Korean Organ Transplant Registry between April 2014 and December 2017. KTs from AKI donors (defined as donors with serum creatinine level. 2 mg/dL) and non-AKI donors (275 cases for each group) were enrolled using a 1:1 propensity score matching. Graft outcomes including graft and patient survival, delayed graft function (DGF), rejection rate, and serially measured estimated glomerular filtration rate (eGFR) were evaluated. Results After propensity matching, KTs from AKI donors showed higher rate of DGF (44.7% vs. 24.0%, p < 0.001). However, the rejection rate was not significantly different between the two groups (KTs from AKI donors vs. KTs from non-AKI donors). eGFRs measured after 6 months, 1 year, 2 years and 3 years were not significantly different by donor AKI status. With median follow-up duration of 3.52 years, cox proportional hazards models revealed hazard ratio of 0.973 (95% confidence interval [CI], 0.584 to 1.621), 1.004 (95% CI, 0.491 to 2.054) and 0.808 (95% confidence interval [CI], 0.426 to 1.532) for overall graft failure, death-censored graft failure and patient mortality, respectively, in KTs from AKI donors compared to KTs from non-AKI donors as a reference. Conclusions KTs from AKI donors showed comparable outcomes to KTs from non-AKI donors, despite a higher incidence of DGF. Results of this study supports the validity of using kidneys from deceased AKI donors in Asian population. | Ha, Jane; Jung, Cheol Woong; Choi, Sunkyu; Kim, Myung-Gyu; Gwon, Jun Gyo; Kim, Joong Kyung; Kim, Chan-Duck; Min, Ji Won; Yang, Jaeseok; Ahn, Curie | Korea Univ, Dept Med, Coll Med, Seoul, South Korea; Korea Univ, Dept Surg, Anam Hosp, Seoul, South Korea; Korea Univ, Dept Biostat, Coll Med, Seoul, South Korea; Korea Univ, Dept Internal Med, Anam Hosp, Seoul, South Korea; Bongseng Mem Hosp, Dept Internal Med, Busan, South Korea; Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Bucheon St Marys Hosp, Div Nephrol, Dept Internal Med, Bucheon, South Korea; Seoul Natl Univ Hosp, Dept Nephrol, Seoul, South Korea | ; Gwon, Jun/AAX-7446-2020; Yang, Jae/LUW-8250-2024 | 57217000677; 7402016375; 57200691637; 36183208900; 50361148000; 56508055400; 8558530700; 56212607100; 57212326527; 7201986669 | cwjung@korea.ac.kr;curie@snu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 11 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0.27 | 2025-07-30 | 5 | 5 | GLOMERULAR-FILTRATION-RATE; SURVIVAL | Acute Kidney Injury; Cohort Studies; Kidney Transplantation; creatinine; acute kidney failure; adult; Article; clinical effectiveness; cohort analysis; deceased donor; delayed graft function; disease registry; estimated glomerular filtration rate; female; follow up; graft rejection; graft survival; human; kidney transplantation; Korea; major clinical study; male; middle aged; multicenter study; risk factor; survival rate; treatment outcome; trend study; acute kidney failure | English | 2021 | 2021-11-17 | 10.1371/journal.pone.0260076 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Implementing psychological first aid ontology | Background This study develops an ontology of Psychological First Aid (PFA) by extracting relevant knowledge from a review of PFA literature. Materials and methods This study was conducted using the PFA ontology development 101 method. This review processes previously-developed PFA studies by consulting Google Scholar, CINHL, PUBMED, and MEDLINE. Protege 5.0 program was used to integrate with ontology development. The developed PFA ontology consisted of eight super classes: Action agenda, Assessment, Concrete method, Disaster type, Disaster disposition, Purpose, Qualification and Skill, Reaction. In total, 166 terms were collected. Results The eight super classes were divided into 72 classes and 64 subclasses. The composition yielded in a total of 166 axioms (85 logical axioms; 81 declaration axioms). Conclusions This study provides basic data to guide development and composition of PFA arbitration programs. | Jung, Hyun-Ok; Han, Seung-Woo | Kyungpook Natl Univ, Coll Nursing, Daegu, South Korea; Kyungil Univ, Dept Emergency Med Technol, Gyongsan, South Korea | 57224449640; 57210797256 | swhan@kiu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0 | 2025-07-30 | 0 | 1 | Disaster Planning; Emergency Responders; First Aid; Health Knowledge, Attitudes, Practice; Health Personnel; Humans; Practice Guidelines as Topic; Resilience, Psychological; article; decision making; disaster; first aid; human; Medline; ontology development; search engine; skill; attitude to health; disaster planning; first aid; health care personnel; organization and management; practice guideline; procedures; psychological resilience; psychology; rescue personnel | English | 2021 | 2021-06-09 | 10.1371/journal.pone.0252891 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Multi-criteria optimization for planning volumetric-modulated arc therapy for prostate cancer | We aimed to compare the volumetric-modulated arc therapy (VMAT) plans with or without multi-criteria optimization (MCO) on commercial treatment-planning systems (Eclipse, Varian Medical System, Palo Alto, CA, USA) for patients with prostate cancer. We selected 25 plans of patients with prostate cancer who were previously treated on the basis of a VMAT plan. All plans were imported into the Eclipse Treatment Planning System version 15.6, and re-calculation and re-optimization were performed. The MCO plan was then generated. The dosimetric quality of the plans was evaluated using dosimetric parameters and dose indices that account for target coverage and sparing of the organs at risk (OARs). We defined the rectum, bladder, and bilateral femoral heads. The VMAT-MCO plan offers an improvement of gross treatment volume coverage with increased minimal dose and reduced maximal dose. In the planning treatment volume, the D-mean and better gradient, homogeneity, and conformity indexes improved despite the increasing hot and cold spots. When implemented through the MCO plan, a steeper fall off the adjacent OARs in the overlap area was achieved to obtain lower dose parameters. MCO generated better sparing of the rectum and bladder through a tradeoff of the increasing dose to the bilateral femoral heads within the tolerable dose constraints. Compared with re-optimization and re-calculation, respectively, significant dose reductions were observed in the bladder (241 cGy and 254 cGy; p<0.001) and rectum (474 cGy and 604 cGy, p<0.001) with the MCO. Planning evaluation and dosimetric measurements showed that the VMAT-MCO plan using visualized navigation can provide sparing of OAR doses without compromising the target coverage in the same OAR dose constraints. | Park, Jongmoo; Park, Jaehyeon; Oh, Sean; Yea, Ji Woon; Lee, Jeong Eun; Park, Jae Won | Kyungpook Natl Univ, Chilgok Hosp, Dept Radiat Oncol, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Radiat Oncol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea | Park, Jin-Hong/F-1829-2014; Park, Ji Won/JCD-9105-2023; Park, Jun/H-7127-2019 | 56180048900; 57208665003; 55305602300; 55305655400; 57206732333; 57225161977 | jelee@knu.ac.kr;kapicap@naver.com; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 9 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0.32 | 2025-07-30 | 6 | 6 | CONFORMAL RADIATION-THERAPY; TOXICITY; RADIOTHERAPY; GENITOURINARY; IMPACT; LIFE | Aged; Aged, 80 and over; Algorithms; Humans; Male; Middle Aged; Prostatic Neoplasms; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Retrospective Studies; adult; aged; Article; bladder; calculation; cancer patient; clinical article; clinical target volume; cohort analysis; computer assisted tomography; dose volume histogram; dosimetry; external beam radiotherapy; femoral head; human; maximum tolerated dose; middle aged; multiobjective optimization; nuclear magnetic resonance imaging; organs at risk; planning target volume; prescription; prostate cancer; radiation dose; rectum; retrospective study; volumetric modulated arc therapy; algorithm; intensity modulated radiation therapy; male; procedures; prostate tumor; radiotherapy planning system; very elderly | English | 2021 | 2021 | 10.1371/journal.pone.0257216 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Multivessel versus IRA-only PCI in patients with NSTEMI and severe left ventricular systolic dysfunction | Background A substantial number of patients presenting with non-ST-elevation myocardial infarction (NSTEMI) and multivessel disease (MVD) have severe left ventricular systolic dysfunction (LVSD) (left ventricular ejection fraction (LVEF) less than 35%). But data are lacking regarding optimal percutaneous coronary intervention (PCI) strategy for these patients. The aim of this study was to compare the long-term outcomes of IRA (infarct-related artery)-only and multivessel PCI in patients with NSTEMI and MVD complicated by severe LVSD. Methods Among 13,104 patients enrolled in the PCI registry from November 2011 to December 2015, patients with NSTEMI and MVD with severe LVSD who underwent successful PCI were screened. The primary outcome was 3-year major adverse cardiovascular events (MACEs), defined as all-cause death, any myocardial infarction, stroke, and any revascularization. Results Overall, 228 patients were treated with IRA-only PCI (n = 104) or MV-PCI (n = 124). The MACE risk was significantly lower in the MV-PCI group than in the IRA-only PCI group (35.5% vs. 54.8%; hazard ratio [HR] 0.561; 95% confidence interval [CI] 0.378-0.832; p = 0.04). This result was mainly driven by a significantly lower risk of all-cause death (23.4% vs. 41.4%; hazard ratio [HR] 0.503; 95% confidence interval [CI] 0.314-0.806; p = 0.004). The results were consistent after multivariate regression, propensity-score matching, and inverse probability weighting to adjust for baseline differences. Conclusions Among patients with NSTEMI and MVD complicated with severe LVSD, multivessel PCI was associated with a significantly lower MACE risk. The findings may provide valuable information to physicians who are involved in decision-making for these patients. | Lee, Myunhee; Kim, Dae-Won; Park, Mahn-Won; Lee, Kyusup; Her, Sung-Ho; Chang, Kiyuk; Chung, Wook Sung; Jeong, Myung Ho; Rha, Seung-Woon; Kim, Hyo-Soo; Gwon, Hyeon Cheol; Seong, In Whan; Hwang, Kyung Kuk; Chae, Shung Chull; Kim, Kwon-Bae; Kim, Young Jo; Cha, Kwang Soo; Oh, Seok Kyu; Chae, Jei Keon; Jung, Ji-Hoon | Catholic Univ Korea, Daejeon St Marys Hosp, Div Cardiol, Coll Med, Daejeon, South Korea; Catholic Univ Korea, St Vincents Hosp, Div Cardiol, Coll Med, Suwon, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Div Cardiol, Coll Med, Seoul, South Korea; Chonnam Natl Univ Hosp, Gwangju, South Korea; Guro Hosp, Seoul, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Seoul, South Korea; Chungnam Natl Univ Hosp, Daejeon, South Korea; Chungbuk Natl Univ Hosp, Cheongju, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Daegu, South Korea; Yeungnam Univ Hosp, Daegu, South Korea; Pusan Natl Univ Hosp, Busan, South Korea; Wonkwang Univ Hosp, Iksan, South Korea; Chonbuk Natl Univ Hosp, Jeonju, South Korea; Korea Inst Toxicol, Daejeon, South Korea | Park, M.J./Y-5611-2019; Lee, Myunhee/KBC-5100-2024; Rha, Seung-Woon/AGE-5810-2022; Kim, Hyo/J-2753-2012 | 57223112782; 57199419487; 57751047500; 57204923370; 12806475600; 25521288100; 7401983318; 56485157500; 8569030400; 33567809200; 6603262426; 35254371300; 7402426370; 7101962036; 8319343800; 57189907572; 7102837700; 24734336000; 26029709000; 57204175011 | mirinesilver@catholic.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 10 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0.11 | 2025-07-30 | 3 | 5 | PERCUTANEOUS CORONARY INTERVENTION; ACUTE MYOCARDIAL-INFARCTION; ISCHEMIC CARDIOMYOPATHY; ARTERY-DISEASE; REVASCULARIZATION; IMPACT; MORTALITY; VIABILITY; SURVIVAL; SURGERY | Aged; Aged, 80 and over; Cardiovascular Diseases; Coronary Vessels; Female; Humans; Male; Middle Aged; Non-ST Elevated Myocardial Infarction; Percutaneous Coronary Intervention; Proportional Hazards Models; Prospective Studies; Registries; Risk Factors; Severity of Illness Index; Treatment Outcome; Vascular Diseases; Ventricular Dysfunction, Left; Ventricular Function, Left; acetylsalicylic acid; angiotensin receptor antagonist; anticoagulant agent; beta adrenergic receptor blocking agent; clopidogrel; dipeptidyl carboxypeptidase inhibitor; fibrinogen receptor antagonist; hydroxymethylglutaryl coenzyme A reductase inhibitor; prasugrel; purinergic P2Y receptor antagonist; ticagrelor; acute kidney failure; aged; all cause mortality; Article; bleeding; cardiogenic shock; cardiovascular mortality; cerebrovascular accident; controlled study; coronary artery disease; female; heart arrhythmia; heart failure; heart infarction; hospital readmission; human; infarct related artery percutaneous coronary intervention; left ventricular systolic dysfunction; major clinical study; male; multivessel percutaneous coronary intervention; non ST segment elevation myocardial infarction; observational study; percutaneous coronary intervention; propensity score; prospective study; repeat procedure; adverse event; cardiovascular disease; complication; coronary blood vessel; heart left ventricle function; middle aged; mortality; non ST segment elevation myocardial infarction; pathology; proportional hazards model; register; risk factor; severity of illness index; treatment outcome; vascular disease; very elderly | English | 2021 | 2021-10-13 | 10.1371/journal.pone.0258525 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | N-[2-(4-benzoyl-1-piperazinyl)phenyl]-2-(4-chlorophenoxy) acetamide is a novel inhibitor of resorptive bone loss in mice | The dynamic balance between bone formation and bone resorption is vital for the retention of bone mass. The abnormal activation of osteoclasts, unique cells that degrade the bone matrix, may result in many bone diseases such as osteoporosis. Osteoporosis, a bone metabolism disease, occurs when extreme osteoclast-mediated bone resorption outstrips osteoblast-related bone synthesis. Therefore, it is of great interest to identify agents that can regulate the activity of osteoclasts and prevent bone loss-induced bone diseases. In this study, we found that N-[2-(4-benzoyl-1-piperazinyl)phenyl]-2-(4-chlorophenoxy) acetamide (PPOAC-Bz) exerted a strong inhibitory effect on osteoclastogenesis. PPOAC-Bz altered the mRNA expressions of several osteoclast-specific marker genes and blocked the formation of mature osteoclasts, suppressing F-actin belt formation and bone resorption activity in vitro. In addition, PPOAC-Bz prevented OVX-induced bone loss in vivo. These findings highlighted the potential of PPOAC-Bz as a prospective drug for the treatment of osteolytic disorders. | Chen, Zhihao; Cho, Eunjin; Ding, Mina; Seong, Jihyoun; Che, Xiangguo; Lee, Sunwoo; Park, Byung-Ju; Choi, Je-Yong; Lee, Tae-Hoon | Chonnam Natl Univ, Dept Mol Med, Grad Sch, Gwangju, South Korea; Chonnam Natl Univ, Dent Sci Res Inst, Korea Mouse Phenotyping Ctr, Dept Oral Biochem,Sch Dent, Gwangju, South Korea; Kyungpook Natl Univ, KNU Convergence Educ Program Biomed Sci Creat Fut, Korea Mouse Phenotyping Ctr,Sch Med, Cell & Matrix Res Inst Korea,Dept Biochem & Cell, Daegu, South Korea; Chonnam Natl Univ, Dept Chem, Gwangju, South Korea | ; Lee, Tae-Hoon/AAR-3708-2021; Lee, Jae-Won/HJP-9840-2023; Choi, Je-Yong/AAR-7334-2021 | 57204542529; 57204184051; 57219660577; 57203153967; 54792660600; 15048323600; 55471707300; 7501391068; 57198752094 | chinaczhihao@gmail.com;thlee83@jnu.ac.kr; | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | J CELL MOL MED | 1582-1838 | 1582-4934 | 25 | 3 | SCIE | CELL BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2021 | 5.295 | 38.5 | 0 | 2025-07-30 | 0 | 0 | acetamide; bone resorption; osteoclastogenesis; piperazine | NF-KAPPA-B; OSTEOCLAST DIFFERENTIATION; RECEPTOR ACTIVATOR; LIGAND; OSTEOPOROSIS; APOPTOSIS; HEALTH | acetamide; bone resorption; osteoclastogenesis; piperazine | acetamide; colony stimulating factor 1; n [2 (4 benzoyl 1 piperazinyl) phenyl] 2 (4 chlorophenoxy) acetamide; osteocalcin; osteoclast differentiation factor; unclassified drug; animal experiment; animal model; animal tissue; Article; bone mass; cell viability; female; immunofluorescence; micro-computed tomography; mouse; nonhuman; ossification; osteoclast; osteoclastogenesis; osteolysis; osteoporosis; Pi3K/Akt signaling; protein expression; real time polymerase chain reaction; Western blotting | English | 2021 | 2021-02 | 10.1111/jcmm.16228 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Prediction of hearing outcomes in chronic otitis media patients underwent tympanoplasty using ossiculoplasty outcome parameter staging or middle ear risk indices | Purpose Ossiculoplasty outcome parameter staging (OOPS) and middle ear risk index (MERI) are the most commonly used indices for predicting prognosis of patients with chronic otitis media (COM). This study aimed to verify the efficiency of OOPS and MERI scores in predicting outcomes of patients with COM who underwent tympanoplasty. Methods We retrospectively reviewed the data of patients who underwent tympanoplasty (n = 526). OOPS, and MERI scores were collected. Hearing data were measured 1 day preoperatively, and 3 and 12 months postoperatively. Operation success was defined according to the Korean Society of Otology guidelines. Results For calculation of success, the ROC values of MERI were 0.551 at 12 months. ROC values of OOPS were 0.637 at 12 months. There were no significant differences in hearing variables among the three groups according to MERI. There were significantly favorable outcomes in hearing variables in the low-risk group in OOPS. The mean OOPS score was greater in patients with success than those with non-success. Otorrhea, ossicle status, and status of mucosa as variables in both indices were associated with success. The type of mastoidectomy as a variable in OOPS alone was associated with success. Absence of hypertension, presence of ossiculoplasty, and use of incus as ossiculoplasty material were associated with poor success rate. Conclusion Compared with MERI, the OOPS index was more closely associated with the hearing outcomes, which may be due to the extent of inflammation in the OOPS index. | Jung, Da Jung; Lee, Hyun Ju; Hong, Ji Song; Kim, Dong Gyu; Mun, Jae Yeon; Bae, Jong-Won; Yoo, Myung Hoon; Lee, Kyu-Yup | Kyungpook Natl Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu, South Korea | ; Lee, Doh Young/GLR-9586-2022 | 57220970862; 57226420013; 57219112643; 57226412874; 57226413631; 57219342705; 22956750000; 22135779500 | kylee@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0.32 | 2025-07-30 | 10 | 12 | PROGNOSTIC-FACTORS; RECONSTRUCTION; DISEASE | Adult; Chronic Disease; Ear, Middle; Humans; Male; Middle Aged; Otitis Media; Prognosis; Retrospective Studies; Treatment Outcome; Tympanoplasty; Young Adult; adult; chronic disease; human; male; middle aged; middle ear; otitis media; prognosis; retrospective study; treatment outcome; tympanoplasty; young adult | English | 2021 | 2021-07-29 | 10.1371/journal.pone.0252812 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Prevalence and distribution pattern of Cryptosporidium spp. among pre-weaned diarrheic calves in the Republic of Korea | Cryptosporidium spp. are protozoan parasites that belong to subphylum apicomplexa and cause diarrhea in humans and animals worldwide. Data on the prevalence of Cryptosporidium spp. and its subtypes among calves in the Republic of Korea (KOR) are sparse. Hence, our study aimed to investigate the prevalence and association between the age of calf and the identified Cryptosporidium spp. and to determine the genotypes/subtypes of Cryptosporidium spp. in pre-weaned calves with diarrhea in the KOR. A total of 460 diarrheic fecal samples were collected from calves aged 1-60 days and screened for Cryptosporidium spp. by the 18S rRNA gene. Species identification was determined using the sequencing analysis of the 18S rRNA gene, and C. parvum-positive samples were subtyped via the sequence analysis of the 60-kDa glycoprotein (gp60) gene. Sequence analysis based on the 18S rRNA gene revealed the presence of three Cryptosporidium spp., namely, C. parvum (n = 72), C. ryanae (n = 12), and C. bovis (n = 2). Co-infection by these species was not observed. The infection rate was the highest in calves aged 11-20 days (26.1%, 95% CI 17.1-35.1), whereas the lowest rate was observed in calves aged 21-30 days (7.7%, 95% CI 0.0-16.1). The prevalence of C. parvum was detected exclusively in calves aged = 31 days of age. The occurrence of C. parvum (chi(2) = 25.300, P = 0.000) and C. ryanae (chi(2) = 18.020, P = 0.001) was significantly associated with the age of the calves. Eleven different subtypes of the IIa family that belonging to C. parvum were recognized via the sequence analyses of the gp60 gene. Except for two (IIaA18G3R1 and IIaA15G2R1) subtypes, nine subtypes were first identified in calves with diarrhea in the KOR. IIaA18G3R1 was the most frequently detected subtype (72.2% of calves), followed by IIaA17G3R1 (5.6%), IIaA15G2R1 (4.2%), IIaA19G4R1 (4.2%), IIaA16G4R1 (2.8%), IIaA17G4R1 (2.8%), IIaA19G3R (2.8%), IIaA14G1R1 (1.4%), IIaA14G3R1 (1.4%), IIaA15G1R1 (1.4%), and IIaA19G1R1 (1.4%) These results suggest that the prevalence of Cryptosporidium spp. is significantly associated with calf age. Furthermore, the findings demonstrate the high genetic diversity of C. parvum and the widespread occurrence of zoonotic C. parvum in pre-weaned calves. Hence, calves are a potential source of zoonotic transmission with considerable public health implications. | Jang, Dong-Hun; Cho, Hyung-Chul; Shin, Seung-Uk; Kim, Eun-Mi; Park, Yu-Jin; Hwang, Sunwoo; Park, Jinho; Choi, Kyoung-Seong | Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Sci & Biotechnol, Sangju, South Korea; Jeonbuk Natl Univ, Coll Vet Med, Iksan, South Korea | 57219426751; 57219427000; 56967385500; 57219722950; 57219426539; 57217125669; 8730126700; 7403949556 | kschoi3@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 11 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0.27 | 2025-07-30 | 7 | 7 | N. SP APICOMPLEXA; DAIRY CALVES; MOLECULAR CHARACTERIZATION; GENETIC DIVERSITY; PARVUM SUBTYPES; GP60 GENOTYPES; FECAL SAMPLES; NEONATAL CALF; CATTLE; HUMANS | Age Factors; Animals; Cattle; Cryptosporidiosis; Cryptosporidium; Diarrhea; DNA, Protozoan; DNA, Ribosomal; Feces; Phylogeny; Prevalence; Republic of Korea; RNA, Ribosomal, 18S; Sequence Analysis, DNA; Weaning; RNA 18S; protozoal DNA; ribosome DNA; RNA 18S; 18S rRNA gene; animal experiment; animal model; Article; calf (bovine); clinical evaluation; coinfection; controlled study; cryptosporidiosis; Cryptosporidium; Cryptosporidium bovis; Cryptosporidium parvum; Cryptosporidium ryanae; diarrhea; disease association; feces analysis; gene; gene sequence; genetic variability; genotype; gp60 gene; groups by age; nonhuman; prevalence; sequence analysis; South Korea; species distribution; weaning; age; animal; bovine; classification; cryptosporidiosis; diarrhea; DNA sequence; feces; genetics; isolation and purification; parasitology; phylogeny; prevalence; procedures; veterinary medicine; weaning | English | 2021 | 2021-11-15 | 10.1371/journal.pone.0259824 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Real-time measurement of intraocular pressure variation during automatic intravitreal injections: An ex-vivo experimental study using porcine eyes | Purpose To measure needle insertion force and change in intraocular pressure (IOP) in real-time during intravitreal injection (IVI). The effects of needle size, insertion speed, and injection rate to IOP change were investigated. Methods Needle insertion and fluid injection were performed on 90 porcine eyeballs using an automatic IVI device. The IVI conditions were divided according to needle sizes of 27-gauge (G), 30G, and 33G; insertion speeds of 1, 2, and 5 mm/s; and injection rates of 0.01, 0.02, and 0.05 mL/s. Insertion force and IOP were measured in real-time using a force sensor and a pressure transducer. Results The peak IOP was observed when the needle penetrated the sclera; the average IOP elevation was 96.3, 67.1, and 59.4 mmHg for 27G, 30G, and 33G needles, respectively. An increase in insertion speed caused IOP elevation at the moment of penetration, but this effect was reduced as needle size decreased: 109.8-85.9 mmHg in 27G for 5-1 mm/s (p = 0.0149) and 61.8-60.7 mmHg in 33G for 5-1 mm/s (p = 0.8979). Injection speed was also related to IOP elevation during the stage of drug injection: 16.65 and 11.78 mmHg for injection rates of 0.05 and 0.01 mL/s (p < 0.001). Conclusion The presented data offers an understanding of IOP changes during each step of IVI. Slow needle insertion can reduce IOP elevation when using a 27G needle. Further, the injection rate must be kept low to avoid IOP elevations during the injection stage. | Park, Ikjong; Park, Han Sang; Kim, Hong Kyun; Chung, Wan Kyun; Kim, Keehoon | POSTECH, Dept Mech Engn, Pohang, South Korea; Kyungpook Natl Univ Hosp, Dept Ophthalmol, Daegu, South Korea | Kim, Hong Kyun/ITT-7758-2023 | 57192195676; 57208186456; 57218260940; 57204958534; 59475350100 | khk@postech.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 16 | 8 | SCIE | MULTIDISCIPLINARY SCIENCES | 2021 | 3.752 | 38.5 | 0.22 | 2025-07-30 | 7 | 6 | TISSUE INTERACTION FORCES; LASIK; MICROKERATOME; FLUCTUATION; SCLERA; MODEL | Animals; Automation; Friction; Humans; Intraocular Pressure; Intravitreal Injections; Kinetics; Mechanical Phenomena; Swine; animal experiment; Article; ex vivo study; experimental study; eye; intraocular pressure; intravitreal drug administration; local field potential; nonhuman; pig; sclera; animal; automation; devices; friction; human; intraocular pressure; intravitreal drug administration; kinetics; mechanics; physiology | English | 2021 | 2021-08-26 | 10.1371/journal.pone.0256344 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A 3D graphics rendering pipeline implementation based on the openCL massively parallel processing | Recently, massively-parallel computing libraries and devices are much widely used, in addition to the traditional 3D graphics systems. In this paper, we present a full 3D fixed-function graphics pipeline, based on the OpenCL, which is one of the most widely used massively-parallel computing library. The full 3D graphics features including WebGL, Web3D and others can be implemented on the massively-parallel computations, without underlying 3D graphics hardware support. Many previous works focused on another massively-parallel system of CUDA, which has a drawback of limited availability. In contrast, we designed and implemented a new architecture with OpenCL, which is now available on various computing devices, including most CPUs, GPUs, and at least theoretically, special-purpose embedded FPGAs. Our work provides full 3D graphics features on OpenCL-capable systems, without dedicated 3D graphics hardware, to finally make 3D graphics features ubiquitous. Technically, we used a top-down approach in its rendering, from the whole screen to precise pixels. At each stage, we tuned our OpenCL implementations and also their global and local parameter spaces. We present the details of our design and also the final result of our implementation, and show its correctness and efficiency. | Kim, Mingyu; Baek, Nakhoon | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | 57201126946; 7007017954 | snow_chris@naver.com;oceancru@gmail.com; | JOURNAL OF SUPERCOMPUTING | J SUPERCOMPUT | 0920-8542 | 1573-0484 | 77 | 7 | SCIE | COMPUTER SCIENCE, HARDWARE & ARCHITECTURE;COMPUTER SCIENCE, THEORY & METHODS;ENGINEERING, ELECTRICAL & ELECTRONIC | 2021 | 2.557 | 38.6 | 0.62 | 2025-07-30 | 13 | 10 | 3D rendering pipeline; OpenCL acceleration; Massively parallel computation; General purpose GPU; Rasterization | 3D rendering pipeline; General purpose GPU; Massively parallel computation; OpenCL acceleration; Rasterization | Parallel processing systems; Pipelines; Program processors; Three dimensional computer graphics; Computing devices; Graphics pipeline; Local parameters; Massively parallel computing; Massively parallel processing; Massively parallel systems; Massively parallels; Top down approaches; Rendering (computer graphics) | English | 2021 | 2021-07 | 10.1007/s11227-020-03581-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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