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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Reduced Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Receiving Long-Term Besifovir Therapy | Simple Summary Further information is necessary regarding the influence of besifovir (BSV), a new nucleotide analogue, on the occurrence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). When we compared the HCC incidence in non-cirrhotic CHB patients receiving BSV with the predicted number derived from the REACH-B (risk estimation for HCC in CHB) model, the standardized incidence ratio (SIR) was significantly reduced to 0.128 at 7 years. The incidence of HCC in patients with cirrhosis was compared using the GAG-HCC (guide with age, gender, HBV DNA, core promotor mutation, and cirrhosis) model, and the SIR was significantly decreased to 0.371 at 7.5 years. HCC prediction was available for BSV-treated patients using existing models. We concluded that BSV decreases the risk of HCC in patients with CHB, and HCC risk prediction models are applicable.Abstract No information is available regarding the influence of besifovir (BSV), a new nucleotide analogue, on the occurrence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). This study evaluated the reduced risk of HCC in patients undergoing BSV treatment. A total of 188 patients with CHB were treated with BSV for up to 8 years. We prospectively assessed the incidence of HCC compared with the risk from prediction models. During the follow-up, 5 patients developed HCC: 1 of 139 patients with non-cirrhotic CHB, and 4 of 49 patients with liver cirrhosis. We compared the HCC incidence in non-cirrhotic and cirrhotic patients with the predicted number derived from the REACH-B (risk estimation for HCC in CHB) model and GAG-HCC (guide with age, gender, HBV DNA, core promotor mutation, and cirrhosis) model, respectively. The standardized incidence ratio (SIR) was 0.128 (p = 0.039) at 7 years in non-cirrhotic CHB patients, and the SIR was 0.371 (p = 0.047) at 7.5 years in cirrhotic patients, suggesting a significantly decreased HCC incidence in both groups. HCC prediction was available for BSV-treated patients using existing models. In conclusion, BSV decreased the risk of HCC in patients with CHB, and prediction models were applicable. Clinical trial registry website and trial number: ClinicalTrials.gov no: NCT01937806. | Yim, Hyung Joon; Kang, Seong Hee; Jung, Young Kul; Ahn, Sang Hoon; Kim, Won; Yang, Jin Mo; Jang, Jae Young; Kweon, Yong Oh; Cho, Yong Kyun; Kim, Yoon Jun; Hong, Gun Young; Kim, Dong Joon; Sohn, Joo Hyun; Lee, Jin Woo; Park, Sung Jae; Yim, Sun Young; Park, Jin Kyung; Um, Soon Ho | Korea Univ, Dept Internal Med, Ansan Hosp, 123 Jeokgeum Ro, Ansan 15355, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea; Seoul Natl Univ, Boramae Med Ctr, Seoul Metropolitan Govt, Dept Internal Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea; Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Internal Med, 93 Jungbu Daero, Suwon 16247, South Korea; Soonchunhyang Univ, Seoul Hosp, Dept Internal Med, 59 Daesagwan Ro, Seoul 04401, South Korea; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Internal Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Internal Med, 29 Saemunan Ro, Seoul 03181, South Korea; Seoul Natl Univ, Dept Internal Med, Seoul Natl Univ Hosp, 101 Daehak Ro, Seoul 03080, South Korea; Seoul Natl Univ Hosp, Liver Res Inst, 101 Daehak Ro, Seoul 03080, South Korea; Kwangju Christian Hosp, Dept Internal Med, 37 Yangnim Ro, Gwangju 503715, South Korea; Hallym Univ, Chuncheon Sacred Heart Hosp, 77 Sakju Ro, Chunchon 24253, South Korea; Hallym Univ, Ctr Liver & Digest Dis, Chuncheon Sacred Heart Hosp, 77 Sakju Ro, Chunchon 24253, South Korea; Hanyang Univ, Guri Hosp, Dept Internal Med, 153 Gyeongchun Ro, Guri 11923, South Korea; Inha Univ Hosp, Dept Internal Med, 27 Inhang Ro, Incheon 22332, South Korea; Inje Univ, Busan Paik Hosp, Dept Internal Med, 75 Bokji ro, Busan 47392, South Korea; Korea Univ, Anam Hosp, Coll Med, Dept Internal Med, 73 Goryeodae Ro, Seoul 02841, South Korea; Ildong Pharmaceut Co, 2,Baumoe Ro 27 gil, Seoul 06752, South Korea | ; Kim, Hee Man/AAF-4253-2020; SANG-HOON, AHN/AAV-2600-2020; Kim, Yoon/J-2746-2012; Yim, Sun/AAX-8128-2020; Kim, Won/H-6940-2019; Ahn, Sang Hoon/AFM-2603-2022; Lee, Jin/AAK-6959-2020 | 7005664934; 55850927200; 25626113500; 7401989551; 57049716700; 58305205500; 57221679776; 7004694832; 35261851400; 25947520600; 44161264800; 57190251856; 57222479854; 57216961138; 24176295000; 57217559329; 58115486900; 57416815200 | gudwns21@korea.ac.kr;dumbo83@korea.ac.kr;2002021168@korea.ac.kr;ahnsh@yuhs.ac;drwon1@snu.ac.kr;jmyangdr@catholic.ac.kr;jyjang@schmc.ac.kr;yokweon@knu.ac.kr;choyk2004.cho@samsung.com;yoonjun@snu.ac.kr;gyh228803@gmail.com;djkim@hallym.ac.kr;sonjh@hanyang.ac.kr;jin@inha.ac.kr;yaheaven@inje.ac.kr;eug203@korea.ac.kr;jkpark@ildong.com;umsh@korea.ac.kr; | CANCERS | CANCERS | 2072-6694 | 16 | 5 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 0.93 | 2025-05-07 | 2 | 2 | antivirals; cancer; carcinogenesis; complications; hepatitis B virus; liver tumor; nucleotide analogues; performance; prediction model; risk reduction | SIMPLE NONINVASIVE INDEX; SIGNIFICANT FIBROSIS; SCORING SYSTEM; PREDICT; CIRRHOSIS; IMPACT | antivirals; cancer; carcinogenesis; complications; hepatitis B virus; liver tumor; nucleotide analogues; performance; prediction model; risk reduction | alanine aminotransferase; antivirus agent; aspartate aminotransferase; besifovir; carnitine; hepatitis B surface antigen; hepatitis B(e) antigen; tenofovir disoproxil; adult; Article; aspartate aminotransferase to platelet ratio index; cancer patient; carcinogenesis; chronic hepatitis B; controlled study; diagnostic test accuracy study; echography; female; Hepatitis B virus; human; liver cell carcinoma; liver cirrhosis; liver tumor; liver ultrasonography; major clinical study; male; middle aged; phase 3 clinical trial; platelet count; prediction; receiver operating characteristic; risk reduction | English | 2024 | 2024-03 | 10.3390/cancers16050887 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Resilience of tigecycline heteroresistance phenotype in Acinetobacter baumannii | Background Heteroresistance, frequently observed in diverse bacterial species, imposes clinical challenges. For this study, we investigated the stability and resilience of tigecycline heteroresistance in Acinetobacter baumannii.Methods Four tigecycline-heteroresistant (HR) A. baumannii strains and resistant populations (RPs) obtained from them were subjected to laboratory evolution assays for 30 days in antibiotic-free media. The heteroresistance phenotype was determined using a population analysis. Bacterial growth curves and in vitro competitiveness were determined to investigate the fitness cost of heteroresistance. Tigecycline efficacy was evaluated using an in vitro time-killing assay. Genetic mutations were identified using whole genome sequencing, and expression of genes in the two-component systems was also evaluated.Results Tigecycline heteroresistance was preserved even in antibiotic-free media, and tigecycline-RPs reverted to heteroresistance during serial culture without tigecycline pressure. The tigecycline-RPs showed a higher fitness cost than their respective HR strains, and the HR strains exhibited a survival advantage upon tigecycline treatment. Although the AdeABC efflux pump was overexpressed in the tigecycline-RPs, it was down-regulated in the HR strains.Conclusions Our data indicate that tigecycline heteroresistance is a highly resilient phenotype in A. baumannii that gives a high fitness advantage to bacteria in terms of competitiveness and response to antibiotic pressure. | Jo, Jeongwoo; Kim, Sun Ju; Kwon, Ki Tae; Ko, Kwan Soo | Sungkyunkwan Univ, Sch Med, Dept Microbiol, Suwon, South Korea; Sungkyunkwan Univ, Sch Pharm, Dept Pharm, Suwon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Kim, Sun Ju/AAE-6520-2022; Kim, Hanjin/KYP-2633-2024 | ksko@skku.edu; | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | J ANTIMICROB CHEMOTH | 0305-7453 | 1460-2091 | 80 | 2 | SCIE | INFECTIOUS DISEASES;MICROBIOLOGY;PHARMACOLOGY & PHARMACY | 2024 | 3.6 | 25.9 | 0 | English | 2024 | 2024-12-04 | 10.1093/jac/dkae436 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | The Clinical Significance of Myosteatosis in Survival Outcomes in Patients with Hepatocellular Carcinoma Treated with Sorafenib | The role of body composition parameters in sorafenib-treated hepatocellular carcinoma (HCC) patients is still not fully elucidated. Here, we aimed to evaluate the impact of computed tomography (CT)-based body composition parameters on the survival of such patients. In this multicenter study, we analyzed the data of 245 sorafenib-treated HCC patients from January 2008 to December 2019. Sarcopenia, visceral obesity, and myosteatosis were defined by using cross-sectional CT images at the third lumbar vertebra level. The effects of these parameters on overall survival (OS) and progression-free survival (PFS) were evaluated. The median age was 67.0 years (interquartile range: 61.0-78.0 year), and 211 patients (86.1%) were male. The median OS and PFS were 7.9 months and 4.8 months, respectively. Vascular invasion (hazard ratio (HR), 1.727; 95% confidence interval (CI), 1.258-2.371; p = 0.001), extrahepatic metastasis (HR, 1.401; 95% CI, 1.028-1.908; p = 0.033), alpha-fetoprotein level > 200 ng/mL (HR, 1.559; 95% CI, 1.105-2.201; p = 0.012), and myosteatosis (HR, 1.814; 95% CI, 1.112-2.960; p = 0.017) were associated with OS. Patient mortality was significantly higher in the group with two or more risk factors than in the group with fewer risk factors. In conclusion, myosteatosis may be a novel prognostic CT-based radiological biomarker in sorafenib-treated HCC patients. | Kang, Min Kyu; Song, Jeong Eun; Jang, Se Young; Kim, Byung Seok; Chung, Woo Jin; Lee, Changhyeong; Park, Soo Young; Tak, Won Young; Kweon, Young Oh; Hwang, Jae Seok; Jang, Byoung Kuk; Lee, Yu Rim; Park, Jung Gil | Yeungnam Univ, Yeungnam Univ Hosp, Coll Med, Dept Internal Med, Daegu 42415, South Korea; Daegu Catholic Univ, Daegu Catholic Univ Hosp, Dept Internal Med, Sch Med, Daegu 42415, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Keimyung Univ, Keimyung Univ Dongsan Hosp, Sch Med, Dept Internal Med, Daegu 42601, South Korea | ; Kim, Seul Kee/A-6076-2015; Kang, Min Kyu/U-8050-2018; Park, Jung/AAK-5167-2020; Kang, Min/U-8050-2018; song, jeong/P-9106-2015 | 59142854300; 57189097150; 57202881977; 55974276800; 55741230500; 55784781600; 57191674344; 7004074582; 7004694832; 57205851488; 58849853600; 57194094753; 57216816399 | kmggood111@naver.com;ssong3004@naver.com;magnolia1103@naver.com;kbs9225@cu.ac.kr;chung50@dsmc.or.kr;chlee1@cu.ac.kr;psyoung0419@gmail.com;eworldcup@gmail.com;yokweon@knu.ac.kr;gastro@dsmc.or.kr;jangha106@dsmc.or.kr;deblue00@naver.com;gsnrs@naver.com; | CANCERS | CANCERS | 2072-6694 | 16 | 2 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 2.1 | 2025-04-16 | 5 | 6 | hepatocellular carcinoma; myosteatosis; sorafenib; survival | OBESITY SKELETAL-MUSCLE; VISCERAL ADIPOSITY; PREDICT POOR; FAT; SARCOPENIA; DEPLETION | hepatocellular carcinoma; myosteatosis; sorafenib; survival | alpha fetoprotein; gadoxetic acid; sorafenib; aged; anthropometry; Article; body composition; body mass; computer assisted tomography; diabetes mellitus; extrahepatic metastasis; female; human; hypertension; intramuscular fat; lipid storage; liver cell carcinoma; lumbar vertebra; male; metastasis; mortality; Myosteatosis; nuclear magnetic resonance imaging; obesity; overall survival; progression free survival; risk factor; sarcopenia; steatosis | English | 2024 | 2024-01 | 10.3390/cancers16020454 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Correction | D-dimer to fibrinogen ratio predicts early neurological deterioration in ischemic stroke with atrial fibrillation (vol 229, pg 219, 2023) | Nam, Ki-Woong; Kim, Chi Kyung; Yu, Sungwook; Oh, Kyungmi; Chung, Jong -Won; Oh, Young Bang; Kim, Gyeong-Moon; Jung, Jin-Man; Song, Tae-Jin; Kim, Yong-Jae; Kim, Bum Joon; Heo, Sung Hyuk; Park, Kwang-Yeol; Kim, Jeong-Min; Park, Jong -Ho; Choi, Jay Chol; Park, Man-Seok; Kim, Joon-Tae; Choi, Kang-Ho; Ha Hwang, Yang; Seo, Woo-Keun | Seoul Natl Univ, Seoul Metropolitan Govt, Dept Neurol, Boramae Med Ctr, Seoul, South Korea; Korea Univ, Coll Med, Dept Neurol, Guro Hosp, Seoul, South Korea; Korea Univ, Korea Univ Anam Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South Korea; Korea Univ, Ansan Hosp, Coll Med, Dept Neurol, Ansan, South Korea; Ewha Womans Univ, Sch Med, Dept Neurol, Seoul, South Korea; Catholic Univ Korea, Dept Neurol, Seoul, South Korea; Asan Med Ctr, Dept Neurol, Seoul, South Korea; Kyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea; Chung Ang Univ, Chung Ang Univ Hosp, Coll Med, Dept Neurol, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Neurol, Seoul, South Korea; Hanyang Univ, Myongji Hosp, Coll Med, Dept Orthopaed Surg, Seoul, South Korea; Jeju Natl Univ, Dept Neurol, Jeju, South Korea; Chonnam Natl Univ Hosp, Dept Neurol, Chungnam, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea; Sungkyunkwan Univ, Dept Digital Hlth, Seoul, South Korea; Korea Univ, Guro Hosp, Dept Neurol, 148 Gurodong Ro, Seoul 08308, South Korea; Korea Univ, Coll Med, 148 Gurodong Ro, Seoul 08308, South Korea | ; Kim, Chi/AAR-9819-2020; Choi, Kangho/HKV-1503-2023; choi, jo/O-5940-2014; Kim, Jinkwon/AAR-6729-2021; Heo, Sung/P-3529-2019; Kim, Jeong-Min/ABH-2469-2021; Jung, Jin-Man/LJL-8037-2024 | 57189377536; 56701057800; 56144716300; 16048029600; 55553751200; 58758898300; 35237139600; 15755814800; 55507164200; 55865497600; 57992430300; 18835720200; 36060099300; 58758898400; 57390600900; 7501392645; 7404490852; 23667663000; 36491173100; 7402311308; 22981667600 | ckkim7@korea.ac.kr; | THROMBOSIS RESEARCH | THROMB RES | 0049-3848 | 1879-2472 | 233 | SCIE | HEMATOLOGY;PERIPHERAL VASCULAR DISEASE | 2024 | 3.4 | 26.0 | 0 | 2025-05-07 | 0 | 0 | D dimer; fibrinogen; adult; aged; article; atrial fibrillation; blood clotting disorder; complication; controlled study; female; fibrinolysis; human; Korea; male; prognosis; deterioration; erratum | English | 2024 | 2024-01 | 10.1016/j.thromres.2023.11.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Enhancing the Performance of an Oscillating Wing Energy Harvester Using a Leading-Edge Flap | In this study, we investigated the power generation capability of an oscillating wing energy harvester featuring an actively controlled flap positioned at the wing's leading edge. The findings revealed that attaching a leading-edge flap reduces fluid flow separation below the wing's lower surface at the leading edge, resulting in smoother flow and increased velocity near the hinge region. The leading-edge flap increases the pressure difference across the wing's surface, thereby enhancing the overall performance. In addition, the introduction of the leading-edge flap effectively elongates the wing's effective projected length in the heaving direction, leading to increased thrust. We examined flap lengths ranging from 10% to 50% of the chord length, with the maximum pitch angles of the wing and flap varying from 75 degrees to 105 degrees and 30 degrees to 55 degrees, respectively. The optimal power generation was achieved using a flap length of 40% of the chord length, combined with maximum wing and flap pitch angles of 95 degrees and 45 degrees, respectively. These conditions yielded a 29.9% overall power output increase and a 20.2% efficiency improvement compared to the case without the leading-edge flap. | Alam, Maqusud; Sohn, Chang Hyun | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | 58274982500; 36806852600 | maqusud1@outlook.com;chsohn@knu.ac.kr; | JOURNAL OF MARINE SCIENCE AND ENGINEERING | J MAR SCI ENG | 2077-1312 | 12 | 1 | SCIE | ENGINEERING, MARINE;ENGINEERING, OCEAN;OCEANOGRAPHY | 2024 | 2.8 | 26.0 | 2.24 | 2025-04-16 | 6 | 6 | energy harvester; flapping wing; leading-edge flap; pitching; heaving | EXTRACTION PERFORMANCE; FOIL; AIRFOIL | energy harvester; flapping wing; heaving; leading-edge flap; pitching | English | 2024 | 2024-01 | 10.3390/jmse12010062 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Performability Evaluation of Autonomous Underwater Vehicles Using Phased Fault Tree Analysis | This paper presents a phased fault tree analysis (phased-FTA)-based approach to evaluate the performability of Autonomous Underwater Vehicles (AUVs) in real time. AUVs carry out a wide range of missions, including surveying the marine environment, searching for specific targets, and topographic mapping. For evaluating the performability of an AUV, it is necessary to focus on the mission-dependent components and/or subsystems, because each mission exploits different combinations of devices and equipment. In this paper, we define a performability index that quantifies the ability of an AUV to perform the desired mission. The novelty of this work is that the performability of the AUV is evaluated based on the reliability and performance of the relevant resources for each mission. In this work, the component weight, expressing the degree of relevance to the mission, is determined using a ranking system. The proposed ranking system assesses the performance of the components required for each mission. The proposed method is demonstrated under various mission scenarios with different sets of faults and performance degradations. | Byun, Sungil; Lee, Dongik | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 55885212200; 55698910600 | bsi880705@naver.com;dilee@ee.knu.ac.kr; | JOURNAL OF MARINE SCIENCE AND ENGINEERING | J MAR SCI ENG | 2077-1312 | 12 | 4 | SCIE | ENGINEERING, MARINE;ENGINEERING, OCEAN;OCEANOGRAPHY | 2024 | 2.8 | 26.0 | 0.4 | 2025-05-07 | 0 | 1 | autonomous underwater vehicle; reliability; performance; performability; phased mission system; phased fault tree analysis | RELIABILITY-ANALYSIS; PERFORMANCE; SYSTEMS; DEPENDABILITY; ALGORITHM; SUBJECT | autonomous underwater vehicle; performability; performance; phased fault tree analysis; phased mission system; reliability | English | 2024 | 2024-04 | 10.3390/jmse12040564 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Examining linguistic and discourse features in oral text production and their dimensionality | Examining the dimensionality of oral discourse language skills in early childhood is crucial in informing theories of language and literacy development. This study examined the factor structure of linguistic and discourse features in oral text production for second graders. A total of 330 English-speaking second graders (Mage = 7.33, 53% boys, 55% White) described three pictures in two discourse conditions. Children's picture descriptions were transcribed verbatim and coded for a total of nine linguistic (e.g. elaborated noun phrase, clausal density) and discourse features (e.g. proper character introduction, perspective taking). Results from confirmatory factor analysis showed that a two-factor structure consisting of linguistic and discourse features factors provided the best fit to the data. Findings suggested that various linguistic and discourse features in oral text production can be best described as having two related but distinct factors. | Cho, Minkyung; Kim, Young-Suk Grace | Kyungpook Natl Univ, Daegu, South Korea; Univ Calif Irvine, Irvine, CA USA; Kyungpook Natl Univ, Teachers Coll, Dept English Educ, 516 Daehak Ro 80, Daegu 41566, South Korea | Cho, Minkyung/HNC-1081-2023 | 57222058853; 59538630600 | minkycho14@gmail.com; | FIRST LANGUAGE | FIRST LANG | 0142-7237 | 1740-2344 | 44 | 2 | AHCI;SSCI | LANGUAGE & LINGUISTICS;LINGUISTICS;PSYCHOLOGY, DEVELOPMENTAL | 2024 | 1.6 | 26.2 | 0 | 2025-05-07 | 0 | 0 | Oral text production; dimensionality; linguistic features; discourse features; second grade; multidimensional model | CORE LANGUAGE SKILL; LISTENING COMPREHENSION; ACADEMIC LANGUAGE; SIMPLE VIEW; CHILDREN; STABILITY; CHILDHOOD; ABILITY; TALK; MIND | dimensionality; discourse features; linguistic features; multidimensional model; Oral text production; second grade | English | 2024 | 2024-04 | 10.1177/01427237231219843 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fully automated quantitative coronary angiography versus optical coherence tomography guidance for coronary stent implantation (FLASH): Study protocol for a randomized controlled noninferiority trial | Background Artificial intelligence-based quantitative coronary angiography (AI-QCA) has been developed to provide a more objective and reproducible data about the severity of coronary artery stenosis and the dimensions of the vessel for intervention in real-time, overcoming the limitations of significant inter- and intraobserver variability, and time-consuming nature of on-site QCA, without requiring extra time and effort. Compared with the subjective nature of visually estimated conventional CAG guidance, AI-QCA guidance provides a more practical and standardized angiography-based approach. Although the advantage of intravascular imaging-guided PCI is increasingly recognized, their broader adoption is limited by clinical and economic barriers in many catheterization laboratories. Methods The FLASH (fully automated quantitative coronary angiography versus optical coherence tomography guidance for coronary stent implantation) trial is a randomized, investigator-initiated, multicenter, open-label, noninferiority trial comparing the AI-QCA-assisted PCI strategy with optical coherence tomography-guided PCI strategy in patients with significant coronary artery disease. All operators will utilize a novel, standardized AI-QCA software and PCI protocol in the AI-QCA-assisted group. A total of 400 patients will be randomized to either group at a 1:1 ratio. The primary endpoint is the minimal stent area (mm2 ), determined by the final OCT run after completion of PCI. Clinical follow-up and cost-effectiveness evaluations are planned at 1 month and 6 months for all patients enrolled in the study. Results Enrollment of a total of 400 patients from the 13 participating centers in South Korea will be completed in February 2024. Follow-up of the last enrolled patients will be completed in August 2024, and primary results will be available by late 2024. Conclusion The FLASH is the first clinical trial to evaluate the feasibility of AI-QCA-assisted PCI, and will provide the clinical evidence on AI-QCA assistance in the field of coronary intervention. | Kim, Yongcheol; Park, Hanbit; Yoon, Hyuck-Jun; Suh, Jon; Kang, Si-Hyuck; Lim, Young-Hyo; Jang, Duck Hyun; Park, Jae Hyoung; Shin, Eun-Seok; Bae, Jang-Whan; Lee, Jang Hoon; Oh, Jun-Hyok; Kang, Do-Yoon; Kweon, Jihoon; Jo, Min-Woo; Park, Duk-Woo; Kim, Young-Hak; Ahn, Jung-Min | Yonsei Univ, Yongin Severance Hosp, Coll Med, Dept Internal Med,Div Cardiol, Yongin, South Korea; Yongin Severance Hosp, Cardiovasc Ctr, Yongin, South Korea; Univ Ulsan, Gangneung Asan Hosp, Coll Med, Dept Med,Div Cardiol, Kangnung, South Korea; Keimyung Univ, Dongsan Hosp, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Dongsan Hosp, Cardiovasc Res Inst, Daegu, South Korea; Soon Chun Hyang Univ Hosp Bucheon, Dept Cardiol, Bucheon, South Korea; Seoul Natl Univ, Bundang Hosp, Cardiovasc Ctr, Dept Internal Med, Seongnam, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Div Cardiol, Seoul, South Korea; Sejong Gen Hosp, Dept Internal Med, Div Cardiol, Bucheon, South Korea; Korea Univ, Anam Hosp, Coll Med, Dept Cardiol,Cardiovasc Ctr, Seoul, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Cardiol, Ulsan, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Div Cardiol, Cheongju, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Natl Univ Hosp, Dept Cardiol, Busan, South Korea; Pusan Natl Univ, Natl Univ Hosp, Med Res Inst, Busan, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Div Cardiol, 388-1 Poongnap Dong, Seoul 138736, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Biomed Engn, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Prevent Med, Seoul, South Korea | Park, Jinwoo/AAD-1328-2022; Kang, Do-Yoon/JPJ-4415-2023; Park, Jin-Young/HDN-0483-2022; Yoon, HJ/IYJ-7484-2023; Kang, Si-Hyuck/AAR-9790-2020; Kim, Young-Hoon/B-5332-2011 | 57192112249; 57205702848; 36175243200; 16426220500; 35740757100; 26537498200; 55641689500; 57206477539; 35273651500; 8699381000; 54581258000; 37111495600; 54782618200; 56675608900; 8597170400; 7403245652; 36067581900; 35408705000 | AMERICAN HEART JOURNAL | AM HEART J | 0002-8703 | 1097-6744 | 275 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2024 | 3.5 | 26.3 | 0.54 | 2025-05-07 | 0 | 1 | INTRAVASCULAR ULTRASOUND; IMPACT; INTERVENTION; LESION; AREA; TERM; PCI | Artificial Intelligence; Coronary Angiography; Coronary Artery Disease; Coronary Stenosis; Coronary Vessels; Equivalence Trials as Topic; Female; Humans; Male; Percutaneous Coronary Intervention; Stents; Surgery, Computer-Assisted; Tomography, Optical Coherence; acetylsalicylic acid; clopidogrel; glyceryl trinitrate; heparin; prasugrel; ticagrelor; adult; Article; artificial intelligence; balloon dilatation; controlled study; coronary angiography; coronary occlusion; cost effectiveness analysis; disease severity; female; follow up; fully automated quantitative coronary angiography; human; implantation; intermethod comparison; interrater reliability; intracoronary drug administration; intrarater reliability; major clinical study; male; middle aged; multicenter study; open study; optical coherence tomography; prospective study; quantitative analysis; randomized controlled trial; South Korea; standardization; artificial intelligence; clinical trial; comparative study; computer assisted surgery; coronary artery disease; coronary blood vessel; coronary stenosis; diagnostic imaging; equivalence trial (topic); percutaneous coronary intervention; procedures; stent; surgery; therapy | English | 2024 | 2024-09 | 10.1016/j.ahj.2024.05.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | A Mechanoluminescent ZnS:Cu/PDMS and Biocompatible Piezoelectric Silk Fibroin/PDMS Hybrid Sensor for Self-Powered Sensing and Artificial Intelligence Control | Mechanoluminescence (ML) is luminescence induced due to mechanical stress, providing intuitive responses to strain-related events. Piezoelectricity is the conversion of mechanical strain into electrical signals, offering a quantitative measurement of force/deformation. Combining ML and piezoelectricity within a single device provides a comprehensive understanding of mechanical events, providing qualitative and quantitative information about strain-related phenomena. A ZnS:Cu/polydimethylsiloxane (PDMS) composite and a biocompatible silk fibroin/PDMS composite are prepared to generate ML and electrical signals, respectively. An innovative method for obtaining powder from silk fabrics is employed. The microstructure and composition of silk fibroin powder are also examined via X-ray diffraction and Fourier Transform Infrared (FTIR) spectroscopy. Mechanical stimuli such as pressure, stretching, twisting, bending, vibration, and rubbing are applied to the device to demonstrate optical and electrical responses. Under pressure, a voltage of 3.82 V and an output current of 201.6 nA are generated at a force of 1 N. Furthermore, a handwritten test is conducted to qualitatively visualize letters based on ML effects and explore the feasibility of using artificial intelligence to classify voltage signals generated during writing into their corresponding letters. This biocompatible, dual-modal self-powered sensor demonstrates broad applicability in wearable technology, biomechanics, human-machine interaction, security, and energy harvesting. A dual-modal self-powered sensor capable of emitting photons and electrical signals in response to mechanical stimuli is fabricated using ZnS:Cu/polydimethylsiloxane (PDMS) composite and a biocompatible silk fibroin/PDMS composite. The hybrid sensor shows response to multiple mechanical stimuli such as pressure, stretching, twisting, bending, vibration, and rubbing. The sensor can be applied to wearable technology, biomechanics, human-machine interaction, security, and energy harvesting. image | Kim, Min-Soo; Timilsina, Suman; Jang, Seong-Min; Kim, Ji-Sik; Park, Sang-Shik | Kyungpook Natl Univ, Dept Nano & Adv Mat Sci & Engn, Gyeongbuk 37224, South Korea; Kyungpook Natl Univ, KNU Res Inst Artificial Intelligent Diag Technol M, Gyeongbuk 37224, South Korea; Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, Gyeongbuk 37224, South Korea | ; Timilisina, Suman/GLT-8029-2022 | 58608961200; 55844969100; 57702842700; 16444690100; 7501833211 | jisikkim@knu.ac.kr;parkss@knu.ac.kr; | ADVANCED MATERIALS TECHNOLOGIES | ADV MATER TECHNOL-US | 2365-709X | 9 | 11 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 6.2 | 26.4 | 1.73 | 2025-05-07 | 3 | 10 | artificial intelligence; mechanoluminescence; piezoelectric; self-powered sensing; silk fibroin | artificial intelligence; mechanoluminescence; piezoelectric; self-powered sensing; silk fibroin | Biocompatibility; Crystallography; Energy harvesting; Fourier transform infrared spectroscopy; II-VI semiconductors; Piezoelectric devices; Vibrations (mechanical); Wearable technology; Zinc sulfide; Electrical signal; Force deformation; Intelligence control; Measurements of; Mechanical strain; Mechanical stress; Piezoelectric; Quantitative measurement; Self-powered sensing; Silk fibroin; Piezoelectricity | English | 2024 | 2024-06 | 10.1002/admt.202400255 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | CuO photocathode enhancement through ultra-thin carbon coating layer for photoelectrochemical water splitting | In this research, we introduce a facile approach utilizing a glucose solution as a precursor to form a protective carbon layer on inherently unstable semiconductor nanostructures, addressing the pervasive issue of photo -corrosion. We focused on CuO photocathode, employing a straightforward technique to envelop them with an ultra-thin, amorphous carbon layer, rendering them suitable for photoelectrochemical (PEC) water-splitting application for hydrogen production. The results demonstrated exceptional photo-stability and significantly improved photocurrent density of CuO arrays equipped with the carbon protective layer. This transformative modification led to a substantial enhancement in PEC performance, yielding a photocurrent density up to 2.19 mA.cm- 2 at 0 V vs. RHE. Furthermore, the maximum photo-to-current conversion efficiency reached 0.12 % at 0.1 V vs. RHE under AM 1.5G illumination condition (100 mW cm-2). In-depth investigations revealed that these enhancements results from accelerated electrochemical charge transfer at the electrode/electrolyte interface and concurrent mitigation of photo-corrosion rates. This approach has the potential to address stability concerns among a broad range of non-stable photoelectrodes, offering significant contributions to the field of energy conversion and the advancement of renewable energy technologies. | Lam, Nguyen Hoang; Truong, Nguyen Tam Nguyen; Ahn, Kwang-Soon; Jo, Younjung; Kang, Seung Beom; Hieu, Nguyen Huu; Shaikh, Shoyebmohamad F.; Kim, Chang-Duk; Lee, Moonyong; Jung, Jae Hak | Yeungnam Univ, Sch Chem Engn, 280 Daehak Ro, Gyeongbuk 38541, South Korea; Kyungpook Natl Univ, Dept Phys, 80 Daehakro, Daegu 41566, South Korea; Korea Carbon Ind Promot Agcy, Res & Dev Ctr, 110-11 Banryong Ro, Jeonju Si 54853, South Korea; Ho Chi Minh City Univ Technol HCMUT, Key Lab Chem Engn & Petr Proc Key CEPP Lab, VNU HCM, Ho Chi Minh City, Vietnam; King Saud Univ, Coll Sci, Dept Chem, POB 2455, Riyadh 11451, Saudi Arabia | Shaikh, Shoyebmohamad/ABC-6005-2020; Nguyen, Anh Tuan/GXF-6089-2022; Lam, Nguyen/KRO-9111-2024; Lee, Moonyong/ADZ-9659-2022 | 58313026700; 59663186100; 7202870619; 13502586500; 57218688331; 55823560700; 56386846700; 57200982445; 56967110700; 13308234300 | tamnguyentn@ynu.ac.kr;mynlee@ynu.ac.kr;jhjung@ynu.ac.kr; | FLATCHEM | FLATCHEM | 2452-2627 | 43 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 6.2 | 26.4 | 2.4 | 2025-04-16 | 7 | 7 | Carbon -coated layer; CuO; Photoelectrochemical; Protective layer; Water splitting | ELECTRONIC-STRUCTURE; HYDROGEN EVOLUTION; NANOWIRE ARRAYS; PERFORMANCE; GRAPHENE; PHOTOACTIVITY; STABILITY; FILMS; CU2O | Carbon-coated layer; CuO; Photoelectrochemical; Protective layer; Water splitting | English | 2024 | 2024-01 | 10.1016/j.flatc.2023.100600 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Facile Lithographic Fabrication of Closed-Loop Reentrant Micromesh via Shape Memory Effect-Induced Suspension for Robust Liquid-Repellency | Imprint lithography is one of the most used techniques for fabricating microstructures, owing to its high efficiency in both costs and time. However, imprinting has limited feasibility in realizing complex microstructures due to difficulties arising from the inherent limitations in the demolding process. Herein, a facile method is demonstrated for fabricating closed-loop reentrant topographies with microscale meshes through a combination of imprint lithography and shape memory polymer (SMP). The mesh structure imprinted onto the pre-pressed SMP pillar array can be elevated by utilizing the form-switchable property of SMP to fabricate suspended micromesh. Suspended micromesh is fully supported by restored SMP micropillar array, exhibiting a closed-loop shape that cannot be achieved with conventional imprint lithographic methods. Also, by the nature of reentrant geometry, liquid-repellency can be realized even for liquids with a lower surface tension than water, offering numerous applications in self-cleaning, droplet manipulation, and antifouling. Various liquid-repellent performances of the fabricated suspended micromesh are investigated and compared to the theoretical expectations for a non-wetting structure, confirming the successful establishment of reentrant topography in the fabricated structures. The proposed lithographic technique can be broadly utilized not only for liquid-repellent surfaces but also for the fabrication of various functional structures. Suspended micromesh exhibiting closed-loop reentrant topography can be established using simple imprint lithography assisted by the shape memory polymer's form-switchable property. Successful formation of the topography is confirmed through evaluation of liquid-repellency based on the comparison between the measured values and calculated values for a non-wetting surface. This closed-loop structure by imprint lithography suggests a new paradigm for microstructure fabrication. image | Lee, Gain; Kang, Bong Su; Kim, Minsu; Kwak, Moon Kyu | Kyungpook Natl Univ, Dept Mech Engn, Daegu 41566, South Korea; Seoul Natl Univ, Ctr Food & Bioconvergence, Dept Food Sci & Biotechnol, Seoul 08826, South Korea | ; Kwak, Moon/F-2786-2012 | 58184185700; 55330925300; 57212315616; 57203947984 | kms1685@knu.ac.kr;mkkwak@knu.ac.kr; | ADVANCED MATERIALS TECHNOLOGIES | ADV MATER TECHNOL-US | 2365-709X | 9 | 24 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 6.2 | 26.4 | 0 | 2025-05-07 | 0 | 0 | closed-loop reentrant topography; Imprint lithography; liquid-repellency; shape memory polymer; suspended micromesh | DRAG REDUCTION; SURFACE; POLYMER | closed-loop reentrant topography; Imprint lithography; liquid-repellency; shape memory polymer; suspended micromesh | Fabrication; Lithography; Microstructure; Shape-memory polymer; Wetting; Closed-loop; Closed-loop reentrant topography; Higher efficiency; Imprint lithography; Liquid repellency; Lithographic fabrication; Micro mesh; Shape memory polymers; Shape-memory effect; Suspended micromesh; Topography | English | 2024 | 2024-12 | 10.1002/admt.202400679 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Highly porous Pt3Ni nanosheets for enhanced hydrogen evolution reaction | Two-dimensional (2D) nanosheets with high surface-to-volume ratios have garnered significant attention for their electrocatalytic properties. This study explores the characterization and electrocatalytic performance of highly porous monometallic platinum (Pt) nanosheets and bimetallic platinum-nickel (Pt3Ni) nanosheets for the hydrogen evolution reaction (HER) in both alkaline and acidic media. Advanced characterization techniques were employed to elucidate the morphological and compositional properties of the Pt and Pt3Ni nanosheets. Electrochemical characterization demonstrated that Pt3Ni nanosheets/C outperformed Pt nanosheets/C and commercial Pt/C in terms of HER activity and stability. The enhanced HER performance of Pt3Ni nanosheets/C is believed to be due to the dominance of the Volmer-Tafel mechanism. These findings highlight the potential of 2D bimetallic nanosheets and suggest a promising avenue for advancing hydrogen energy technologies. | Kabiraz, Mrinal Kanti; Wahidah, Hafidatul; Hong, Jong Wook; Choi, Sang-Il | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Univ Ulsan, Dept Chem, Ulsan 44610, South Korea; Korea Inst Energy Technol KENTECH, Sch Energy Technol Hydrogen Energy, Naju 58330, South Korea | Choi, Sangil/N-7571-2013; Kabiraz, Mrinal/AAE-6381-2020 | 57201400780; 57808870000; 57215820078; 56167600800 | jwhong@kentech.ac.kr;sichoi@knu.ac.kr; | FLATCHEM | FLATCHEM | 2452-2627 | 48 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 6.2 | 26.4 | 0.94 | 2025-05-07 | 3 | 3 | 2D; PtNi; Nanosheet; Hydrogen evolution reaction; Mechanism | OXYGEN REDUCTION; ELECTROCATALYSTS; CARBON; EFFICIENT; SURFACE; ENERGY; SHAPE; NANOCRYSTALS; NANOWIRES; CATALYSTS | 2D; Hydrogen evolution reaction; Mechanism; Nanosheet; PtNi | English | 2024 | 2024-11 | 10.1016/j.flatc.2024.100750 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Quantum phase structural stability and switching in twist-graphenes | This study examines the electronic structure and potential energy surfaces of migration paths in various types of bilayer graphene. Using periodic boundary conditions, density functional theory (DFT), and the generalized gradient approximation (GGA) exchange-correlation functional, along with the nudged elastic band (NEB) method, to investigate the structural stability and dynamic equilibrium of twisted bilayer graphenes (TBGs) with twist angles of 13.2 degrees and 21.8 degrees. The results suggest that twist angles significantly impact atomic and electronic properties, including moire patterns, superlattice periods, and interfragment distances, which in turn influence bilayer graphene strongly correlated electronic quantum states. This research elucidates the fundamental mechanisms of superlubricity and mutual migration pathways of graphene fragments in TBGs. The low migration barriers observed could facilitate transitions between different energy-related phases, which are determined by the lattice moire patterns and the localization character of the electronic states, resulting in superlubricity. External mechanical factors may affect the quantum properties of TBGs, indicating potential applications in quantum computing and quantum sensing. | Melchakova, Iu. A.; Oyeniyi, G. T.; Engelgardt, D. R.; Polyutov, S. P.; Avramov, P. V. | ITMO Univ, Sch Phys & Engn, St Petersburg 197101, Russia; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Siberian Fed Univ, Int Res Ctr Spect & Quantum Chem IRC SQC, Svobodniy Pr 79 10, Krasnoyarsk 600041, Russia | ; Melchakova, Iuliia/KGM-5967-2024; Polyutov, Sergey/M-6417-2013 | 57206720228; 57737965200; 59152547900; 6507259627; 7004322420 | paul.veniaminovich@knu.ac.kr; | FLATCHEM | FLATCHEM | 2452-2627 | 47 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 6.2 | 26.4 | 0 | 2025-05-07 | 0 | 0 | Twisted bilayered graphene; PES; Migration; Heterostructure; DFT; Tribology | INITIO MOLECULAR-DYNAMICS; ELASTIC BAND METHOD; MAGIC-ANGLE; ATOMIC-STRUCTURE; POINTS; STATES | DFT; Heterostructure; Migration; PES; Tribology; Twisted bilayered graphene | English | 2024 | 2024-09 | 10.1016/j.flatc.2024.100702 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Assembly of the Human Multi-tRNA Synthetase Complex Through Leucine Zipper Motifs | Aminoacyl-tRNA synthetases (ARSs) are responsible for the ligation of amino acids to their cognate tRNAs. In human, nine ARSs form a multi-tRNA synthetase complex (MSC) with three ARS-interacting multifunctional proteins (AIMPs). Among the components of MSC, arginyl-tRNA synthetase 1 (RARS1) and two AIMPs (AIMP1 and AIMP2) have leucine zipper (LZ) motifs, which they utilize for their assembly in an MSC. RARS1 and AIMP1 have two LZ motifs (LZ1 and LZ2) in their N-terminus, respectively, while AIMP2 has one LZ motif between its lysyl-tRNA synthetase 1 (KARS1)-binding motif and glutathione transferase-homology domain, which links aspartyl-tRNA synthetase 1 (DARS1). Although the interaction mode between AIMP1 and RARS1, which also binds glutaminyl-tRNA synthetase 1 (QARS1), has been revealed, the mode in the presence of AIMP2 is still ambiguous since AIMP2 is known to not only bind to AIMP1 but also form a homodimer through its LZ. Here, we determined a crystal structure of the LZ complex of AIMP1 and AIMP2 and revealed the interaction mode of a heterotrimeric complex of RARS1, AIMP1, and AIMP2. The complex is established by a three-stranded coiled-coil structure with RARS1 LZ1, AIMP1 LZ1, and AIMP2 LZ and is completed with a two-stranded coiled-coil structure of RARS1 LZ2 and AIMP1 LZ2. In the human MSC, this heterotrimeric complex of RARS1, AIMP1, and AIMP2 allows for a subcomplex of fourteen protein molecules, in which two QARS1-RARS1-AIMP1-AIMP2-2 KARS1 complexes are linked separately to a dimeric DARS1. (c) 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies. | Kim, Dong Kyu; Lee, Kayoung; Kang, Beom Sik | Kyungpook Natl Univ, Sch Life Sci & Biotechnol, KNU Creat BioRes Grp, Daegu 41566, South Korea | 57210928800; 59416629200; 35082104200 | bskang2@knu.ac.kr; | JOURNAL OF MOLECULAR BIOLOGY | J MOL BIOL | 0022-2836 | 1089-8638 | 436 | 23 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 4.5 | 26.5 | 0 | 2025-05-07 | 0 | 0 | PROTEIN-PROTEIN INTERACTIONS; RAY SOLUTION SCATTERING; MACROMOLECULAR ASSEMBLAGE; STRUCTURE REFINEMENT; PROGRAM; BINDING; TOOLS; ATP | aminoacyl-tRNA synthetase; coiled-coil structure; protein assembly; protein–protein interaction | Amino Acyl-tRNA Synthetases; Arginine-tRNA Ligase; Crystallography, X-Ray; Cytokines; Humans; Leucine Zippers; Models, Molecular; Neoplasm Proteins; Nuclear Proteins; Protein Binding; Protein Multimerization; RNA-Binding Proteins; Tryptophan-tRNA Ligase; amino acid transfer RNA ligase; AIMP2 protein, human; amino acid transfer RNA ligase; arginine transfer RNA ligase; cytokine; leucine zipper protein; nuclear protein; protein binding; RNA binding protein; small inducible cytokine subfamily E, member 1; tryptophan transfer RNA ligase; tumor protein; WARS1 protein, human; affinity chromatography; amino acid sequence; amino terminal sequence; Article; basic leucine zipper motif; binding affinity; binding site; chemical structure; cloning; computer model; conformational transition; crystal structure; crystallization; data mining; Escherichia coli; hydrogen bond; mass spectrometry; molecular docking; mutagenesis; neurite outgrowth; polyacrylamide gel electrophoresis; protein assembly; protein expression; protein interaction; protein motif; protein protein interaction; protein purification; protein structure; proton transport; pull-down assay; RNA binding; sequence analysis; signal noise ratio; site directed mutagenesis; size exclusion chromatography; stoichiometry; ubiquitination; X ray crystallography; chemistry; genetics; human; metabolism; molecular model; protein multimerization | English | 2024 | 2024-12-01 | 10.1016/j.jmb.2024.168865 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Building Resilience and Social-Emotional Competencies in Elementary School Students through a Short-Term Intervention Program Based on the SEE Learning Curriculum | This study explored the positive effects of a six-week Social-Emotional and Ethical Learning (R) (SEE Learning) program on resilience and social and emotional competences, adapted for elementary students in Daegu, South Korea, a region strongly affected by the first outbreak of COVID-19. A total of 348 third- and fourth-grade students from 15 elementary schools participated, and the curriculum was tailored, emphasizing key areas such as resilience, attention, kindness, attention training, and compassion. Repeated measures analysis of variance (RMANOVA) tests showed statistically significant improvements between pre- and post-tests in resilience and its subscales, including self-efficacy, tolerance of negative affect, positive support relations, power of control, and spontaneity, as well as in social and emotional competencies, including emotional regulation, social skills, empathy, and social tendencies. Despite a lack of maintenance in all areas, at follow-up, the mean scores for self-efficacy, tolerance of negative affect, and positive support relations, as well as emotional regulation, social skills, empathy, and social tendency, remained higher than pre-test levels, suggesting some lasting benefits. The findings underscore the potential of the SEE Learning program integrated with resilience, mindfulness, compassion, and ethical practices to enhance students' resilience and social and emotional well-being. This study contributes to the growing body of evidence supporting the use of mindfulness and compassion-based SEL programs to mitigate the adverse effects of traumatic events on children's mental health. | Min, Hee Jung; Park, Sang-Hee; Lee, Seung-Hyun; Lee, Bo-Hwa; Kang, Mikyung; Kwon, Mi Ju; Chang, Myung Ju; Negi, Lobsang Tenzin; Samphel, Tsondue; Won, Seunghee | Dongguk Univ WISE, Dept Children & Adolescent Educ, Gyeongju 38066, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu Student Suicide Prevent Ctr, Daegu 41404, South Korea; Emory Univ, Ctr Contemplat Sci & Compass Based Ethics, Atlanta, GA 30322 USA; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu 41944, South Korea | 55039235100; 57402023800; 59188972800; 59188818000; 59188510500; 59188510600; 59188895400; 25030913700; 57311995000; 35278955600 | aravindamhj@gmail.com;bomhangi@hanmail.net;pigmandarin@gmail.com;ibohwa030@gmail.com;godk-mk@hanmail.net;pkwkmj@naver.com;2-yab@hanmail.net;snegi@emory.edu;tsamphe@emory.edu;wonsh864@knu.ac.kr; | BEHAVIORAL SCIENCES | BEHAV SCI-BASEL | 2076-328X | 14 | 6 | SSCI | PSYCHOLOGY, MULTIDISCIPLINARY | 2024 | 2.5 | 26.5 | 1.22 | 2025-05-07 | 3 | 3 | COVID-19; elementary students; resilience; social-emotional development; SEE learning | MINDFULNESS; COMPASSION | COVID-19; elementary students; resilience; SEE learning; social–emotional development | English | 2024 | 2024-06 | 10.3390/bs14060458 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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