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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells | Autophagy is a pivotal biological process responsible for maintaining the homeostasis of intracellular organelles. Yet the molecular intricacies of peroxisomal autophagy (pexophagy) remain largely elusive. From a ubiquitin-related chemical library for screening, we identified several inhibitors of the Von Hippel-Lindau (VHL) E3 ligase, including VH298, thereby serving as potent inducers of pexophagy. In this study, we observed that VH298 stimulates peroxisomal degradation by ATG5 dependently and escalates the ubiquitination of the peroxisomal membrane protein ABCD3. Interestingly, the ablation of NBR1 is similar to the curtailed peroxisomal degradation in VH298-treated cells. We also found that the pexophagy induced by VH298 is impeded upon the suppression of gene expression by the translation inhibitor cycloheximide. Beyond VHL inhibition, we discovered that roxadustat, a direct inhibitor of HIF-alpha prolyl hydroxylase, is also a potent inducer of pexophagy. Furthermore, we found that VH298-mediated pexophagy is blocked by silencing HIF-1 alpha. In conclusion, our findings suggest that VH298 promotes pexophagy by modulating VHL-mediated HIF-alpha transcriptional activity. | Kim, Yong Hwan; Park, Na Yeon; Jo, Doo Sin; Bae, Ji-Eun; Kim, Joon Bum; Park, Kyuhee; Jeong, Kwiwan; Kim, Pansoo; Yeom, Eunbyul; Cho, Dong-Hyung | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat Bio Res Grp, Daegu 41566, South Korea; ORGASIS Corp, Suwon 16229, South Korea; Kyungpook Natl Univ, KNU Inst Basic Sci, Coll Nat Sci, KNU LAMP Res Ctr, Daegu 41566, South Korea; Gyeonggido Business & Sci Accelerator, Bio Ind Dept, Suwon 16229, South Korea; Kyungpook Natl Univ, Organelle Inst, Daegu 41566, South Korea | Choi, Hye Rin/JDV-9065-2023; Kim, Joon/ADP-8066-2022 | 57204676401; 57190609826; 56335489800; 57190605352; 57190611030; 57194598552; 57197993212; 59548676400; 56058004100; 35093684400 | yoo035913@gmail.com;dhcho@knu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 29 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.6 | 25.5 | 0 | 2025-04-16 | 0 | 0 | VH298; VHL E3 ligase; HIF-alpha; autophagy; pexophagy | PEROXISOME; AUTOPHAGY; DEGRADATION; DISORDERS | autophagy; HIF-α; pexophagy; VH298; VHL E3 ligase | Autophagy; Cyclopropanes; HeLa Cells; Homeostasis; Humans; Macroautophagy; Pyrrolidines; Thiazoles; Von Hippel-Lindau Tumor Suppressor Protein; cyclopropane derivative; pyrrolidine derivative; thiazole derivative; VH298; VHL protein, human; von Hippel Lindau protein; genetics; HeLa cell line; homeostasis; human; macroautophagy | English | 2024 | 2024-01 | 10.3390/molecules29020482 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Investigation of Corrosion Behavior of Oxygen-Free Copper Canisters in Groundwater Chemistry of Deep Geological Repositories | The disposal of nuclear waste represents a paramount concern for human safety, and the corrosion resistance of containers within the disposal environment stands as a critical factor in ensuring the integrity of such waste containment systems. In this report, the corrosion behavior of copper canisters was monitored in Olkiluoto-simulated/-procured groundwater (South Korea) with different temperatures. The exposure of copper in the procured groundwater at 70 °C revealed a 3.7-fold increase in corrosion vulnerability compared with room temperature conditions, with a current density of 12.7 μA/cm2. During a three-week immersion test in a controlled 70 °C chamber, the canister in the Korean groundwater maintained a constant weight. In contrast, its counterpart in the simulated groundwater revealed continuous weight loss, indicating heightened corrosion. An X-ray diffraction (XRD) analysis identified corrosion byproducts, specifically Cu2Cl3(OH) and calcite (CaCO3), in the simulated groundwater, confirming its corrosive nature. The initial impedance analysis revealed distinct differences: Korean groundwater exhibits high pore resistance and diffusion effects, while the simulated groundwater shows low pore resistance. Consequently, the corrosion of copper canisters in the Korean environment is deemed relatively stable because of significant differences in ion concentrations. © 2023 by the authors. | Yun, Tae Ho; Kim, Taeyong; Kim, Seunghyun; Kim, Jisoo | Department of Precision Mechanical Engineering, Kyungpook National University (KNU), 2559 Gyeongsang-daero, Gyeongsangbuk-do, Sangju-si, 37224, South Korea; Department of Advanced Science and Technology Convergence, Kyungpook National University (KNU), 2559 Gyeongsang-daero, Gyeongsangbuk-do, Sangju-si, 37224, South Korea; Joining Technology Department, Korea Institute of Materials Science (KIMS), 797 Changwon-daero, Gyeongsangnam-do, Changwon-si, 51508, South Korea; Department of Precision Mechanical Engineering, Kyungpook National University (KNU), 2559 Gyeongsang-daero, Gyeongsangbuk-do, Sangju-si, 37224, South Korea, Department of Advanced Science and Technology Convergence, Kyungpook National University (KNU), 2559 Gyeongsang-daero, Gyeongsangbuk-do, Sangju-si, 37224, South Korea | 55383561400; 57934043800; 57189732178; 57192647685 | js.kim@knu.ac.kr;skims@kims.re.kr; | Materials | MATERIALS | N/A | 1996-1944 | 17 | 1 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 3.2 | 25.5 | 0.72 | 2025-04-16 | 2 | canister; electrochemical impedance spectroscopy (EIS); high-temperature deep geological disposal; Korean groundwater | Calcite; Chlorine compounds; Copper corrosion; Corrosion resistance; Corrosive effects; Electrochemical corrosion; Electrochemical impedance spectroscopy; Geology; Oxygen; Safety factor; X ray diffraction analysis; Canister; Copper canisters; Corrosion behaviour; Deep geological disposal; Electrochemical impedance spectroscopy; Electrochemical-impedance spectroscopies; High-temperature deep geological disposal; Highest temperature; Korean groundwater; Simulated ground water; Groundwater | English | Final | 2024 | 10.3390/ma17010074 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Metabolic Engineering of Komagataella phaffii for Xylose Utilization from Cellulosic Biomass | Cellulosic biomass hydrolysates are rich in glucose and xylose, but most microorganisms, including Komagataella phaffii, are unable to utilize xylose effectively. To address this limitation, we engineered a K. phaffii strain optimized for xylose metabolism through the xylose oxidoreductase pathway and promoter optimization. A promoter library with varying strengths was used to fine-tune the expression levels of the XYL1, XYL2, and XYL3 genes, resulting in a strain with a strong promoter for XYL2 and weaker promoters for XYL1 and XYL3. This engineered strain exhibited superior growth, achieving 14 g cells/L and a maximal growth rate of 0.4 g cells/L-h in kenaf hydrolysate, outperforming a native strain by 17%. This study is the first to report the introduction of the xylose oxidoreductase pathway into K. phaffii, demonstrating its potential as an industrial platform for producing yeast protein and other products from cellulosic biomass. | Park, Jongbeom; Park, Sujeong; Evelina, Grace; Kim, Sunghee; Jin, Yong-Su; Chi, Won-Jae; Kim, In Jung; Kim, Soo Rin | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea; Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA; Natl Inst Biol Resources, Species Divers Res Div, Incheon 22689, South Korea; Gyeongsang Natl Univ, Inst Agr & Life Sci, Dept Food Sci & Technol, Jinju 52828, South Korea | ; Jin, Yong-Su/L-4530-2013; Kim, Soo Rin/X-2192-2019 | 57223133187; 57218916250; 58758964300; 59199868800; 57204009076; 7006817223; 57195531808; 36659584200 | bum5743@gmail.com;tya198@naver.com;graceevelina@gmail.com;sunghee.kimmmm@gmail.com;ysjin@illinois.edu;wjchi76@korea.kr;ij0308@gnu.ac.kr;soorinkim@knu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 29 | 23 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.6 | 25.5 | 0 | 2025-05-07 | 0 | 0 | Komagataella phaffii; xylose metabolism; promoter library; lignocellulose; kenaf | RECOMBINANT SACCHAROMYCES-CEREVISIAE; PICHIA-PASTORIS; PROTEIN EXPRESSION; XYLITOL DEHYDROGENASE; FERMENTATION; CULTIVATION; XYL2; IMPROVEMENT; PROMOTERS; PATHWAY | kenaf; Komagataella phaffii; lignocellulose; promoter library; xylose metabolism | Biomass; Cellulose; Fermentation; Komagataella phaffii; Metabolic Engineering; Promoter Regions, Genetic; Saccharomycetales; Xylose; cellulose; xylose; biomass; budding yeast; fermentation; genetics; Komagataella phaffii; metabolic engineering; metabolism; procedures; promoter region | English | 2024 | 2024-12 | 10.3390/molecules29235695 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Strength Prediction of Non-Sintered Hwangto-Substituted Concrete Using the Ultrasonic Velocity Method | This paper presents and investigates the properties of concrete in which a portion of the cement is substituted with non-sintered Hwangto (NSH), a readily available building material in Asia. Given the inactive nature of NSH, this study aimed to determine the optimal cement replacement ratio and quantitative strength of the material. The unit weight, compressive strength, ultrasonic pulse velocity (UPV), and stress-strain of the NSH concrete (NSHC) were evaluated. Additionally, we developed a predictive model for determining compressive strength based on the regression analysis of compressive strength and UPV. The water-to-binder ratio was set to 0.41, 0.33, and 0.28, and the NSH replacement rates in the cement were set to 0%, 15%, 30%, and 45% for evaluating various strength ranges. The mechanical property measurements indicated reductions of 5.35% in unit weight, 35.62% in compressive strength, and 6.34% in UPV as the NSH was replaced. Notably, the smallest deviation from plain concrete was observed at a replacement rate of 15%. The scanning electron microscopy analysis results showed that the plain concrete exhibited a crystalloid structure; however, as the NSH replacement rate increased, the amorphous structure and pores increased while unreacted NSH particles were also observed. The X-ray diffraction analysis results demonstrate that the peak intensities for kaolinite and mullite increased as the NSH replacement rate increased, while those of C-S-H gel and CaO showed low peak intensities. Furthermore, the regression analysis concluded that an exponential function was suitable. Consequently, a compressive strength prediction model was developed, and in the error test, the NSHC model demonstrated an average error of <10%, with fewer errors at the lower compressive strength boundaries. | Im, Hajun; Kim, Wonchang; Choi, Hyeonggil; Lee, Taegyu | Semyung Univ, Dept Fire & Disaster Prevent, Jecheon 27136, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, Daegu 41566, South Korea | 58803568700; 57659934800; 56430165800; 7501437272 | haha1578@naver.com;kimwc69082@gmail.com;hgchoi@knu.ac.kr;ltg777@semyung.ac.kr; | MATERIALS | MATERIALS | 1996-1944 | 17 | 1 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 3.2 | 25.5 | 0.72 | 2025-04-16 | 1 | 2 | non-sintered Hwangto; mechanical properties; ultrasonic pulse velocity; compressive strength; prediction model; regression analysis; microstructural analysis | PULSE VELOCITY; COMPRESSIVE STRENGTH; WATER-CONTENT; METAKAOLIN; AGGREGATE; CEMENT | compressive strength; mechanical properties; microstructural analysis; non-sintered Hwangto; prediction model; regression analysis; ultrasonic pulse velocity | Cements; Concretes; Errors; Exponential functions; Forecasting; Kaolinite; Light velocity; Mullite; Regression analysis; Scanning electron microscopy; Titanium dioxide; X ray powder diffraction; Microstructural analysis; Non-sintered hwangto; Peak intensity; Plain concrete; Prediction modelling; Properties of concretes; Replacement rates; Strength prediction; Ultrasonic pulse velocity; Unit weight; Compressive strength | English | 2024 | 2024-01 | 10.3390/ma17010174 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Substitution Effect of a Single Nitrogen Atom on π-Electronic Systems of Linear Polycyclic Aromatic Hydrocarbons (PAHs): Theoretically Visualized Coexistence of Mono- and Polycyclic π-Electron Delocalization | We theoretically investigated the nitrogen substitution effect on the molecular structure and pi-electron delocalization in linear nitrogen-substituted polycyclic aromatic hydrocarbons (N-PAHs). Based on the optimized molecular structures and magnetic field-induced parameters of fused bi- and tricyclic linear N-PAHs, we found that the local pi-electron delocalization of subcycles (e.g., mono- and bicyclic constituent moieties) in linear N-PAHs is preserved, despite deviation from ideal structures of parent monocycles. The introduction of a fused five-membered ring with a pyrrolic N atom (N-5MR) in linear N-PAHs significantly perturbs the pi-electronic condition of the neighboring fused six-membered ring (6MR). Monocyclic pyrrole exhibits substantial bond length alternations, strongly influencing the pi-electronic systems of both the fused N-5MR and 6MR in linear N-PAHs, depending on the location of shared covalent bonds. A fused six-membered ring with a graphitic N atom in an indolizine moiety cannot generate monocyclic pi-electron delocalization but instead contributes to the formation of polycyclic pi-electron delocalization. This is evidenced by bifurcated diatropic ring currents induced by an external magnetic field. In conclusion, the satisfaction of Huckel's 4n + 2 rule for both mono- and polycycles is crucial for understanding the overall pi-electron delocalization. It is crucial to consider the unique characteristics of the three types of substituted N atoms and the spatial arrangement of 5MR and 6MR in N-PAHs. | Lim, Jong Min; Shim, Sangdeok; Bui, Hoa Thi; Kim, Jimin; Kim, Ho-Joong; Hwa, Yoon; Cho, Sung | Kyungpook Natl Univ, Dept Chem Educ, Daegu 41566, South Korea; Sunchon Natl Univ, Dept Chem, Sunchon 57922, South Korea; Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea; Chosun Univ, Dept Chem, Gwangju 61452, South Korea; Arizona State Univ, Sch Elect Comp & Energy Engn, Tempe, AZ 85287 USA | Hwa, Yoon/J-3128-2013; Bui, Hoa/GZA-9346-2022 | 55230588200; 55694061300; 59101185800; 56517693400; 57157852700; 35733900300; 57218324589 | jongmin@knu.ac.kr;san90@scnu.ac.kr;hoak52ahoahoc@gmail.com;jiminkim@chonnam.ac.kr;hjkim@chosun.ac.kr;yoon.hwa@asu.edu;scho@chonnam.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 29 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2024 | 4.6 | 25.5 | 2.17 | 2025-05-07 | 4 | 5 | polycyclic aromatic hydrocarbons; heteroatom effect; pi-electron delocalization; aromaticity; pi-conjugation | FIELD-EFFECT TRANSISTORS; CHEMICAL-SHIFTS NICS; ACID | aromaticity; heteroatom effect; polycyclic aromatic hydrocarbons; π-conjugation; π-electron delocalization | indolizine; nitrogen; polycyclic aromatic hydrocarbon; pyrrole; article; atom; chemical structure; conjugation; controlled study; covalent bond; electron; electronic device; female; magnetic field | English | 2024 | 2024-02 | 10.3390/molecules29040784 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synthesis of Long Alkyl and Fluoroalkyl Substituted Siloxane Copolymers for the Water Repellency of Rammed Earth Walls | Rammed earth in a built environment has vapor diffusion characteristics and humidity control abilities, each of which is respectively attributed to the porous structures and the hydrophilic properties. Indeed, these structures and properties allow for the easy absorbance of water particles, hence affecting the durability of a rammed earth wall. This paper presents the water-repellency method for rammed earth walls, which utilizes siloxane copolymers containing fluorine. The water-repellent properties are investigated by measuring the contact angle, water absorption rate, and compressive strength after spray-coating with the synthesized siloxane copolymers on the surface of the rammed earth specimens under study. The water contact angle of the specimen, coated with a siloxane copolymer containing 10 mol.% of a silane monomer with a fluorine group, is about 140 degrees. The water absorption of the specimen obtained after immersing in water for 24 h is low, at about 3.5 wt.%. In addition, the compressive strength remains more than 80% of the corresponding strength of the specimen which is not immersed in water. It is confirmed that the use of a 10% by volume of the siloxane copolymer containing the fluorine group may enhance the water-repellent performance and economic competitiveness. | Yoon, Keun-Byoung; Kim, Mu-Jin; Lee, Dong-Eun; Kim, Hee-Seon | Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea; ICAS Co Ltd, Corp R&D Ctr, Daegu 41566, South Korea | 7401607550; 58805391100; 56605563300; 58805161200 | kbyoon@knu.ac.kr;anwlc9833l@gmail.com;dolee@knu.ac.kr;momm1225@naver.com; | MATERIALS | MATERIALS | 1996-1944 | 17 | 1 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 3.2 | 25.5 | 0.36 | 2025-04-16 | 0 | 1 | water repellency; siloxane copolymer; rammed earth wall | PROTECTION; COATINGS | rammed earth wall; siloxane copolymer; water repellency | Compressive strength; Fluorine; Humidity control; Plastic coatings; Walls (structural partitions); Water absorption; Waterproofing; Built environment; Diffusion characteristics; Humidity-control; Hydrophilic properties; Porous structures; Rammed earth; Rammed earth walls; Siloxane copolymers; Vapour diffusions; Water-repellency; Contact angle | English | 2024 | 2024-01 | 10.3390/ma17010216 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Different Properties of Geopolymer Composites Reinforced with Flax Fibers and Carbon Fibers | The main motivation for this research was to improve the properties of geopolymers by reinforcement using synthetic and natural fibers, and to gain new knowledge regarding how the nature and/or the quantity of reinforcement fibers influences the properties of the final geopolymers. The main objective was to investigate the effects of different types of reinforcement fibers on the properties of the geopolymers. These reinforcement fibers were mainly environmentally friendly materials that can be used as alternatives to ordinary Portland cement. The authors used fly ash and river sand as the raw materials for the matrix, and added carbon fibers (CF), flax fibers (FF), or a hybrid of both (CFM) as reinforcements. The samples were prepared by mixing, casting, and curing, and then subjected to various tests. The main research methods used were compressive strength (CS), flexural strength (FS), water absorption (WA), abrasion resistance (B & ouml;hme's disk method), microstructure analysis (SEM), chemical composition (XRF), and crystal structure analysis (XRD). The results showed that the addition of fibers partially improved the mechanical properties of the geopolymers, as well as reducing microcracks. The CF-reinforced geopolymers exhibited the highest compressive strength, while the FF-reinforced geopolymers showed the lowest water absorption. The authors, based on previous research, also discussed the factors that influence fiber-matrix adhesion, and the optimal fiber content for geopolymers. | Brugaletta, Francesca; Becher, Anton Frederik; Rostagno, Danilo Laurent; Kim, JeongHye; Fresneda Medina, Jose Ignacio; Ziejewska, Celina; Marczyk, Joanna; Korniejenko, Kinga | Univ Catania, Fac Chem Engn Ind Sustainabil, Dept Civil Engn & Architecture, Piazza Univ 2, I-95124 Catania, Italy; Tech Univ Bergakad Freiberg, Inst Maschinenkunde & Fertigungstech, Gustav Zeuner Str 7, D-09599 Freiberg, Germany; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Biofibers & Mat Sci, 80 Daehak Ro, Daegu 41566, South Korea; Univ Politecn Valencia, Fac Mech Engn, Plaza Ferrandiz & Carbonell, Valencia 03801, Spain; Cracow Univ Technol, Fac Mat Engn & Phys, 37 Jana Pawla II St, PL-31864 Krakow, Poland | ; Korniejenko, Kinga/AAE-4907-2019 | 59170624500; 59170201500; 59171055200; 59170912300; 59170490600; 57205656339; 57205657038; 57190986563 | francescabrugaletta@outlook.com;antibe02@gmail.com;danilo.rostagno@gmail.com;gloria1211@knu.ac.kr;ignacio.fresneda.medina@gmail.com;celina.ziejewska@pk.edu.pl;joanna.marczyk@pk.edu.pl;kinga.korniejenko@pk.edu.pl; | MATERIALS | MATERIALS | 1996-1944 | 17 | 11 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 3.2 | 25.5 | 0.99 | 2025-05-07 | 5 | 5 | geopolymer; carbon fiber; flax fiber; composite | MECHANICAL-PROPERTIES; BEHAVIOR | carbon fiber; composite; flax fiber; geopolymer | Carbon fibers; Flax; Fly ash; Geopolymers; Hybrid materials; Inorganic polymers; Portland cement; Reinforced plastics; Water absorption; Flax fibres; Geopolymer; Geopolymer composites; matrix; Ordinary Portland cement; Property; Reinforcement fibers; Research method; River sands; Synthetic and natural fibers; Compressive strength | English | 2024 | 2024-06 | 10.3390/ma17112633 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | The Interplay Between Endoplasmic Reticulum Stress and Oxidative Stress in Chondrocyte Catabolism | Objective: Oxidative stress and endoplasmic reticulum (ER) stress play pivotal roles in disrupting the homeostasis of chondrocytes by producing catalytic proteases and enhancing chondrocyte senescence, consequently contributing to the progression of osteoarthritis (OA). Despite their close interaction, the underlying molecular mechanisms remain poorly understood. Here, we show that ER stress and oxidative stress reciprocally modulate each other to promote cartilage degradation. Methods: Primary chondrocytes were obtained from the articular cartilage of 5-day-old C57BL/6J mice by excising distal femur and proximal tibia. Tunicamycin was applied to induce ER stress in primary chondrocytes. Surgical OA was induced in 12-week-old male C57BL/6J mice by destabilizing the medial meniscus (DMM). Results: Tunicamycin-induced ER stress led to an increase in the production of reactive oxygen species (ROS) and catalytic proteases, including MMP13 and Adamts5, in primary chondrocytes, and it was primarily dependent on the NADPH oxidase (NOX) system. ER stress directly increased the expression of NOX2, NOX3, NOX4, and p22phox. Specifically, the protein kinase RNA-like ER kinase (PERK) pathway is involved in the expression of NOX4 and p22phox, the inositol-requiring enzyme 1 alpha (IRE1α) pathway in NOX2 and NOX3 expression, and the activating transcription factor 6 (ATF6) pathway influences NOX3 expression in chondrocytes. Conversely, inhibiting NOX function significantly reduced both ER stress sensor–related signaling and chondrocyte catabolism, thereby decelerating the progression of surgically induced OA in vivo. Conclusions: Our findings highlight the positive feedback loop between ER stress and oxidative stress in OA pathogenesis, suggesting that targeting NOX isoforms is a promising therapeutic strategy for OA. © The Author(s) 2024. | Kim, Yu Jung; Han, Jin; Han, Seungwoo | Laboratory for Arthritis and Cartilage Biology, Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, South Korea; Laboratory for Arthritis and Cartilage Biology, Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, South Korea; Laboratory for Arthritis and Cartilage Biology, Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, South Korea, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea | 58993543600; 57218360938; 55246807000 | kiefedr@knu.ac.kr; | Cartilage | CARTILAGE | 1947-6035 | 1947-6043 | SCIE | ORTHOPEDICS | 2024 | 2.7 | 25.5 | 3.3 | 2025-04-16 | 6 | chondrocyte; ER stress; NADPH oxidase; osteoarthritis; oxidative stress | English | Article in press | 2024 | 10.1177/19476035241245803 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | The Removal of Strontium Ions from an Aqueous Solution Using Na-A Zeolites Synthesized from Kaolin | Sr2+ ions in an aqueous solution were removed using Na-A zeolites synthesized from kaolin, a natural mineral. Na-A zeolites with high crystallinity were synthesized using NaOH/kaolin mass ratios of 0.6 (ZK06) and 0.9 (ZK09). The adsorption reached equilibrium within 120 min. The adsorption data obtained from experiments for Sr2+ using ZK06 and ZK09 were appropriately analyzed with pseudo-second-order kinetic and Langmuir isotherm models. Comparing the maximum adsorption capacities (qm) of ZK06 and ZK09 for Sr2+, the highest values were obtained at 1.90 and 2.42 mmol/g, respectively. Consequently, the Na-A zeolites synthesized from kaolin can be evaluated as adsorbents with high adsorption capacities for the removal of Sr2+, proportional to the degree of their crystallinity. | Lim, Woo-Ri; Lee, Chang-Han; Lee, Chung-Mo | Kyungpook Natl Univ, KNU Inst Basic Sci, Coll Nat Sci, KNU LAMP Res Ctr, Daegu 41566, South Korea; Catholic Univ Pusan, Dept Environm Adm, Busan 46252, South Korea; Pusan Natl Univ, Dept Geol Sci, Busan 46241, South Korea; Pusan Natl Univ, Inst Future Earth, Busan 46241, South Korea | Lee, Chang-Han/AAG-9178-2019 | 57211041754; 56011098800; 57188824015 | wooriful@naver.com;chlee@cup.ac.kr;chungmo@pusan.ac.kr; | MATERIALS | MATERIALS | 1996-1944 | 17 | 3 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 3.2 | 25.5 | 0.66 | 2025-05-07 | 2 | 2 | adsorption; Na-A zeolite; crystallinity; radioactive waste; strontium | RADIOACTIVE STRONTIUM; SODIUM NONATITANATE; SORPTION; ADSORPTION; BEHAVIOR; SR2+; CS+ | adsorption; crystallinity; Na-A zeolite; radioactive waste; strontium | Crystallinity; Isotherms; Kaolin; Sodium hydroxide; Strontium; Zeolites; Adsorption data; Cristallinity; High crystallinity; Kinetic isotherms; Mass ratio; Na-A zeolite; Natural minerals; Pseudo second order kinetics; Strontium ion; Synthesised; Adsorption | English | 2024 | 2024-02 | 10.3390/ma17030575 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Improved frequency performance in AlGaN/GaN HEMTs on Si using hydrogen silsesquioxane-assisted gate | AlGaN/GaN HEMTs have been regarded as the most promising option for achieving high-frequency power amplifier in various applications, including wireless communication, aerospace, and radar systems. To enable their use at even higher frequency, we conducted a study to enhance the frequency characteristics of AlGaN/GaN high electron mobility transistors (HEMTs) on a silicon substrate. By employing a hydrogen silsesquioxane (HSQ)-assisted gate, AlGaN/GaN HEMT with an LG of 0.17 mu m and LSD of 5 mu m exhibited a VTH of 4.5 V, ID.max of 885 mA/mm, and gm.max of 253 mS/mm. The planar-gate without HSQ shows VTH of 4.4 V, ID.max of 876 mA/mm, and gm.max of 258 mS/mm. The DC characteristics are comparable to those observed in planar-gate HEMT with a conventional gate structure. Though the DC characteristics of both devices are similar, the HSQ-assisted gate HEMT exhibits a higher fT/fmax of 55/89 GHz, whereas the planar-gate HEMT yields anfT/fmax of 38/64 GHz. The 32% reduction in the total extrinsic gate capacitance (Cgs + Cgd) is the major contributor to the improved frequency performance of the HSQ-assisted gate AlGaN/GaN HEMT. The adoption of HSQ-assisted gate AlGaN/GaN HEMTs presents itself as a highly advantageous choice for achieving higher-frequency operations. (c) 2023 Elsevier Inc. All rights reserved. | Jung, Hyun-Wook; Choi, Il-Gyu; Kim, Do-Hyun; Jung, Hyeon-Seok; Choi, Su-Min; Chang, Sung-Jae; Ahn, Ho-Kyun; Lim, Jong-Won; Kang, Dong-Min; Kim, Dae-Hyun; Won, Sang Min | Elect & Telecommun Res Inst, RF Power Components Res Sect, Daejeon 34129, South Korea; Sungkyunkwan Univ, Dept Elect & Comp Engn, Suwon 16419, South Korea; Kyungpook Natl Univ, Elect & Elect Engn Dept, Daegu 41566, South Korea | WON, SANG/IXN-0563-2023; Won, Sang Min/IXN-0563-2023; Jung, Hyun/F-6898-2013; Kim, Junghwan/AAQ-9204-2021 | 57192233439; 56424837700; 57203012552; 58852938100; 57825819100; 36699164100; 55704330000; 7403453759; 57213749090; 57212363794; 26423371000 | sangminwon@skku.edu; | MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING | MAT SCI SEMICON PROC | 1369-8001 | 1873-4081 | 170 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2024 | 4.6 | 25.8 | 0.65 | 2025-05-07 | 1 | 3 | AlGaN/GaN on Si; High-electron-mobility-transistors (HEMTs); HSQ; Gate structure; High-frequency | RF PERFORMANCE; GAN HEMTS; POWER | AlGaN/GaN on Si; Gate structure; High-electron-mobility-transistors (HEMTs); High-frequency; HSQ | Aluminum gallium nitride; Electron mobility; Gallium nitride; Hydrogen; III-V semiconductors; Power amplifiers; Silicon; AlGaN/GaN high electron mobility transistors; AlGaN/GaN on si; DC characteristics; Frequency performance; Gate structure; High electron-mobility transistors; High frequency HF; High frequency power; High-electron-mobility-transistor; Hydrogen silsesquioxane; High electron mobility transistors | English | 2024 | 2024-02 | 10.1016/j.mssp.2023.107985 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Dihydrotestosterone Enhances MICA-Mediated Immune Responses to Epstein-Barr Virus-Associated Gastric Carcinoma | Simple Summary Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a type of stomach cancer linked to EBV infection. This study explores how the male hormone dihydrotestosterone (DHT) affects the immune response against EBVaGC. Using the SNU719 cell line, we treated the cells with DHT and observed an increased expression of the androgen receptor (AR) and the activation of the NF-kappa B pathway. This led to higher levels of MICA, a protein that interacts with immune cells like natural killer (NK) and T cells, enhancing their ability to kill EBVaGC cells. Importantly, this immune boost occurred without increasing harmful inflammatory signals. Our findings suggest that DHT enhances the immune system's ability to target EBVaGC, providing a potential therapeutic approach by modulating androgen signaling to improve anti-tumor immunity.Abstract Background: Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a subset of gastric cancers linked to EBV infection. While the role of male hormones in cancers such as prostate, breast, and ovarian cancers is well-studied, their impact on EBVaGC remains less understood. This study aims to examine the effect of dihydrotestosterone (DHT) on EBVaGC, particularly focusing on its influence on the immune response. Methods: The study utilized the SNU719 EBVaGC cell line. Cells were treated with DHT to assess androgen receptor (AR) expression and the activation of signaling pathways, including NF-kappa B. The expression of MHC class I polypeptide-related sequence A (MICA) and its interaction with the NKG2D receptor on NK and T cells was evaluated. Cytotoxicity assays were conducted to determine DHT's effect on NK and T cell-mediated cytotoxicity, and proinflammatory cytokine gene expression was analyzed. Results: DHT significantly increased AR expression in EBVaGC cells and activated the NF-kappa B pathway, which led to increased transcription of target genes such as MICA and EBNA1. These changes enhanced the interaction with receptors on NK and T cells, thereby boosting their cytotoxicity against EBVaGC cells. Importantly, DHT did not upregulate proinflammatory cytokine genes. Conclusion: DHT enhances the immune response against EBVaGC by upregulating MICA and activating NK and T cells. These findings suggest potential therapeutic strategies targeting androgen signaling to improve anti-tumor immunity in EBVaGC. | Seo, Donghyun; Byun, Hyeji; Cho, Miyeon; Lee, Sun Hee; Youn, Sohyun; Lee, Junho; Jung, Inuk; Cho, Hyosun; Kang, Hyojeung | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Vessel Organ Interact Res Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Surg, Daegu 41566, South Korea; Duksung Womens Univ, Coll Pharm, Duksung Innovat Drug Ctr, Seoul 01369, South Korea | Jung, Inuk/T-1981-2018 | 58079865000; 59347283300; 57190213901; 58607352900; 59347828200; 57219032336; 56067575500; 55572361200; 8979751700 | puppu04050@naver.com;qkek0810@naver.com;cmy1004g@knu.ac.kr;ihappy278@knu.ac.kr;yshggid@gmail.com;2009045032@knu.ac.kr;inukjung@knu.ac.kr;hyosun1102@duksung.ac.kr;hkang72@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 16 | 18 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 0.47 | 2025-05-07 | 3 | 3 | androgen receptor; dihydrotestosterone; Epstein-Barr virus; MICA; NF-kappa B | NF-KAPPA-B; ANDROGEN RECEPTOR; CELL; TRANSCRIPTION; ACTIVATION; RESISTANCE; PROMOTER; PROTEIN | androgen receptor; dihydrotestosterone; Epstein–Barr virus; MICA; NF-κB | androgen receptor; androstanolone; gamma interferon; interleukin 16; interleukin 18; lactate dehydrogenase; MHC class I polypeptide-related sequence A; natural killer cell receptor NKG2D; peptides and proteins; puromycin; stromal cell derived factor 1; synaptotagmin I; unclassified drug; Article; cancer cell line; chemiluminescence immunoassay; chromatin immunoprecipitation polymerase chain reaction; coimmunoprecipitation; confocal microscopy; controlled study; cytotoxicity assay; EBNA1 gene; EBNA2 gene; Epstein Barr virus; Epstein Barr virus infection; expression vector; flow cytometry; fluorescence activated cell sorting; gene; gene editing; gene expression; genetic transfection; HEK293T cell line; high throughput sequencing; human; human cell; immune response; immunocompetent cell; immunofluorescence assay; luciferase assay; male; MHCA gene; MHCB gene; natural killer cell; NF kB signaling; NK-92 cell line; NTB-A gene; peripheral blood mononuclear cell; polymerase chain reaction; prostate cancer; protein expression; protein phosphorylation; RAET1G gene; RELA gene; reverse transcription polymerase chain reaction; signal transduction; SNU-719 cell line; stomach carcinoma; tumor immunity; Western blotting; YCCEL1 cell line | English | 2024 | 2024-09 | 10.3390/cancers16183219 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of fluorescent brighteners on the insecticidal activity of Bacillus thuringiensis var. kurstaki and LdMNPV on Lymantria dispar asiatica in Korea | Stilbene-based fluorescent brighteners (FBs) have been demonstrated to improve the insecticidal activities of entomopathogenic viruses; however, there is limited information regarding their effect on entomopathogenic bacteria. We conducted this study to investigate the effect of two FBs (FB 28 and FB 71) on the insecticidal activities of Bacillus thuringiensis var. kurstaki (Btk) and Lymantria dispar multiple nuclear polyhedrosis virus (LdMNPV) on Lymantria dispar asiatica. FB 28 and Btk combination at low concentration (1.6 x 10(2) IU/mL) increased the mortality, whereas FB 71 and Btk combination at intermediate and high concentrations (1.6 x 10(3) and 1.6 x 10(4) IU/mL) slightly reduced the mortality compared with that with Btk alone. The lethal time was also shorter with combinations of Btk and FB 28 than with FB 71. Both FB 28 and FB 71 increased the mortality in combination with LdMNPV at all concentrations (3 x 10(2), 3 x 10(4), and 3 x 10(6) polyhedral occlusion bodies/mL compared with that with LdMNPV alone. Our results suggest that FBs improve the insecticidal activities of Btk and LdMNPV, and their activities depend on their interactions with the midgut structures of the host insect species. | de Carvalho, Lucas Mezione; Hwang, Hwal-Su; Lee, Kyeong-Yeoll | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Appl Biol, Daegu, South Korea; Kyungpook Natl Univ, Sustainable Agr Res Ctr, Gunwi, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Plant Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Plant Med, Daegu, South Korea | 58726255300; 57204055221; 57217153096 | leeky@knu.ac.kr; | ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY | ARCH INSECT BIOCHEM | 0739-4462 | 1520-6327 | 115 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;ENTOMOLOGY;PHYSIOLOGY | 2024 | 1.9 | 25.9 | 0.68 | 2025-04-16 | 1 | 1 | biological control; entomopathogenic microbes; fluorescent brighteners; insecticidal enhancement; spongy moth | GYPSY-MOTH LEPIDOPTERA; OPTICAL BRIGHTENERS; PERITROPHIC MEMBRANE; CALCOFLUOR WHITE; CONGO RED; NUCLEOPOLYHEDROVIRUS | biological control; entomopathogenic microbes; fluorescent brighteners; insecticidal enhancement; spongy moth | Animals; Bacillus thuringiensis; Flighted Spongy Moth Complex; Insecticides; Lymantria dispar multiple nucleopolyhedrovirus; Moths; Nucleopolyhedroviruses; Republic of Korea; insecticide; animal; Bacillus thuringiensis; Baculoviridae; moth; South Korea | English | 2024 | 2024-01 | 10.1002/arch.22066 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Localized Radiotherapy for Classic Kaposi's Sarcoma: An Analysis of Lesion Characteristics and Treatment Response | Simple Summary This study aimed to evaluate the efficacy of radiotherapy for skin lesions in classic Kaposi's sarcoma. A retrospective analysis was performed. Response after radiotherapy was defined as follows: Complete response indicated no clinically detectable skin lesions and no symptoms. Partial response was defined as a reduction in lesion height by more than half or a lighter lesion color compared to before treatment. In-field recurrence was defined as the appearance of new lesions within a previously irradiated field. The overall response rate was 100%. The efficacy of radiotherapy was evident, even in cases involving disseminated lesions. Further research on the optimal dose and fractionation is deemed necessary.Abstract Objectives: Classic Kaposi's sarcoma (CKS) is a rare malignancy with diverse clinical presentations, lacking a standard treatment. While localized therapies are commonly used for symptomatic lesions, radiotherapy (RT) has demonstrated effectiveness. This study aims to evaluate the efficacy of RT for treating skin lesions in CKS. Methods: A retrospective analysis was conducted on patients with KS treated between April 2012 and January 2024. In total, 69 lesions in 16 patients were included. Treatment response was defined as follows: complete response (CR) indicated the absence of clinically detectable skin lesions and symptoms; partial response (PR) was a reduction in lesion height by more than half or a lighter lesion color compared to before treatment. In-field recurrence was the appearance of new lesions within a previously irradiated field. Logistic regression analysis was used to investigate factors influencing response and in-field recurrence. Results: The median follow-up period was 52 months (range, 3-138 months). The overall response rate was 100%, with 92.8% of the patients achieving CR and 7.2% receiving PR. PR was observed in three patients with five lesions, all of which remained stable. In-field recurrence occurred in two patients with initially advanced disease, and all recurrent lesions responded to RT. No variables were significantly associated with response or in-field recurrence. Conclusions: RT for CKS showed a 100% response rate, with complete symptom relief in all cases. The effectiveness of RT was evident, even in cases involving disseminated lesions. Further research is needed to determine the optimal RT dose and fractionation. | Park, Junhee; Lee, Jeong Eun | Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu 41944, South Korea | 57210104861; 57206732333 | jhp1247@knuh.kr;jelee@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 16 | 18 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 0 | 2025-05-07 | 0 | 0 | Kaposi's sarcoma; Kaposi sarcoma; radiotherapy; RT | DOSE-RATE BRACHYTHERAPY; RADIATION-THERAPY; DNA-SEQUENCES; MANAGEMENT; TRENDS; TRIAL; ERA | Kaposi sarcoma; Kaposi’s sarcoma; radiotherapy; RT | Human immunodeficiency virus antibody; adult; aged; Article; brain hemorrhage; bullous dermatitis; cancer localization; cancer radiotherapy; cancer recurrence; cancer staging; computer assisted tomography; desquamation; electron therapy; excisional biopsy; female; histopathology; hyperpigmentation; immunohistochemistry; irradiation; Kaposi sarcoma; local therapy; lymphedema; male; overall response rate; photon therapy; polymerase chain reaction; positron emission tomography-computed tomography; radiation dose; radiation dose fractionation; radiation toxicity; re-irradiation; recurrence risk; retrospective study; skin biopsy; skin defect; skin exfoliation; skin induration; skin pain; therapeutic equivalent dose; three-dimensional imaging; total hip replacement; treatment response; very elderly | English | 2024 | 2024-09 | 10.3390/cancers16183194 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Outcome of Atezolizumab Plus Bevacizumab Combination Therapy in High-Risk Patients with Advanced Hepatocellular Carcinoma | Simple Summary Although ATE + BEV treatment provides improved therapeutic efficacy, in our study, high-risk populations such as patients with grade Vp4 portal vein thrombus, bile duct invasion, or more than 50% liver infiltration had poor responses. This study aimed to investigate real-world outcomes and prognostic factors in high-risk patients with advanced HCC treated with atezolizumab plus bevacizumab. Unlike what was reported in the IMbrave150 study, atezolizumab plus bevacizumab treatment had consistent efficacy and tolerability in both the total and high-risk population in our study. Radiation therapy combined with atezolizumab plus bevacizumab treatment might be helpful to improve progression-free survival and overall survival in high-risk groups.Abstract Real-world data regarding treatment with atezolizumab plus bevacizumab in high-risk patients with advanced HCC are lacking. In this multicenter retrospective cohort study, a total of 215 patients with advanced HCC received atezolizumab plus bevacizumab treatment at four tertiary hospitals. High-risk patients were those with grade Vp4 portal vein thrombus, bile duct invasion, or more than 50% liver infiltration. In total, 98 (45.6%) were the high-risk population, 186 (86.5%) were considered to be Child-Pugh class A, and 128 (59.5%) had previously received neoadjuvant or concomitant radiation treatment. Median overall survival (OS) was 11.25 months (95% CI, 9.50-13.10), and the median progression-free survival (PFS) was 8.00 months (95% CI, 6.82-9.18). In the high-risk population, the median OS was 10 months (95% CI, 8.19-11.82) and the median PFS was 6.50 months (95% CI, 3.93-9.08). In the high-risk population, multivariate analysis indicated that radiation therapy and lower ALBI grade were associated with better OS and PFS. A total of 177 (82.3%) patients experienced adverse events of any grade, the most common being proteinuria (23.7%). Atezolizumab plus bevacizumab treatment showed consistent efficacy and tolerability in both the total and high-risk population. Radiation therapy combined with atezolizumab plus bevacizumab treatment might be helpful to improve PFS and OS in high-risk populations. | Hwang, Sang Youn; Woo, Hyun Young; Heo, Jeong; Kim, Hyung Jun; Park, Young Joo; Yi, Ki Youn; Lee, Yu Rim; Park, Soo Young; Chung, Woo Jin; Jang, Byoung Kuk; Tak, Won Young | Dongnam Inst Radiol & Med Sci, Dept Internal Med, Busan 46033, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Biomed Res Inst, Coll Med, Busan 49241, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Keimyung Univ, Dept Internal Med, Sch Med, Daegu 42601, South Korea | Heo, Jeong/MHQ-1390-2025 | 55466667900; 12787138800; 8422238800; 58622129500; 56697660800; 57491758400; 57194094753; 57191674344; 55741230500; 58849853600; 7004074582 | mongmani@daum.net;who54@hanmail.net;jheo@pusan.ac.kr;phorni@naver.com;juya0630@naver.com;yikiyoun@hanmail.net;deblue00@naver.com;psyoung0419@gmail.com;chung50@dsmc.or.kr;jangha106@dsmc.or.kr;wytak@knu.ac.kr; | CANCERS | CANCERS | 2072-6694 | 16 | 4 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 0.93 | 2025-05-07 | 2 | 3 | hepatocellular carcinoma; atezolizumab; bevacizumab; radiation | 3-DIMENSIONAL CONFORMAL RADIOTHERAPY; ENDOTHELIAL GROWTH-FACTOR; RADIATION-THERAPY; TUMOR THROMBUS; ANEMIA; CANCER; SORAFENIB; IMMUNOTHERAPY; IPILIMUMAB; MATURATION | atezolizumab; bevacizumab; hepatocellular carcinoma; radiation | alanine aminotransferase; aspartate aminotransferase; atezolizumab; bevacizumab; bilirubin; immunoglobulin A; immunoglobulin G; proton pump inhibitor; adult; angiography; Article; bone scintiscanning; cancer growth; cancer staging; chemoembolization; Child Pugh score; computer assisted tomography; drug combination; drug therapy; drug withdrawal; endoscopy; esophagogastroduodenoscopy; female; follow up; Hepacivirus; hepatectomy; high risk patient; human; length of stay; liver cell carcinoma; male; Model For End Stage Liver Disease Score; multiple cycle treatment; overall survival; palliative therapy; prevalence; progression free survival; prothrombin time; radiation dose; radiofrequency ablation; retrospective study; sustained virologic response; tertiary care center | English | 2024 | 2024-02 | 10.3390/cancers16040838 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Real-World Outcomes of Crizotinib in ROS1-Rearranged Advanced Non-Small-Cell Lung Cancer | Simple Summary Crizotinib, an oral tyrosine kinase inhibitor that targets ALK, MET, and ROS1 kinase, has emerged as an effective treatment for ROS1-rearranged NSCLC. In South Korea's real-world setting, characterized by a higher elderly population and increased brain/central nervous system metastasis rates, crizotinib remains a cornerstone in treating ROS1-rearranged NSCLC, providing lasting clinical benefits with a favorable safety profile. Liquid biopsies, utilizing biomarkers, are instrumental in detecting targetable mutations, monitoring the disease burden, and identifying resistance mechanisms. In our study, next-generation sequencing using cell-free total nucleic acids enables the detection of ROS1 fusions and the identification of resistance mechanisms during disease progression.Abstract Real-world data on the use and outcomes of crizotinib in ROS1-rearranged non-small-cell lung cancer (NSCLC) are limited. This study aims to analyze the real-world efficacy of crizotinib in South Korea and explore the utilization of liquid biopsies that implement next-generation sequencing (NGS) using cell-free total nucleic acids. In this prospective multicenter cohort study, 40 patients with ROS1-rearranged NSCLC, either starting or already on crizotinib, were enrolled. Patients had a median age of 61 years, with 32.5% presenting brain/central nervous system (CNS) metastases at treatment initiation. At the data cutoff, 48.0% were still in treatment; four continued with it even after disease progression due to the clinical benefits. The objective response rate was 70.0%, with a median duration of response of 27.8 months. The median progression-free survival was 24.1 months, while the median overall survival was not reached. Adverse events occurred in 90.0% of patients, primarily with elevated transaminases, yet these were mostly manageable. The NGS assay detected a CD74-ROS1 fusion in 2 of the 14 patients at treatment initiation and identified emerging mutations, such as ROS1 G2032R, ROS1 D2033N, and KRAS G12D, during disease progression. These findings confirm crizotinib's sustained clinical efficacy and safety in a real-world context, which was characterized by a higher elderly population and higher rates of brain/CNS metastases. The study highlights the clinical relevance of liquid biopsy for detecting resistance mechanisms, suggesting its value in personalized treatment strategies. | Kim, Hyeon Hwa; Lee, Jae Cheol; Oh, In-Jae; Kim, Eun Young; Yoon, Seong Hoon; Lee, Shin Yup; Lee, Min Ki; Lee, Jeong Eun; Park, Chan Kwon; Lee, Kye Young; Lee, Sung Yong; Kim, Seung Joon; Lim, Jun Hyeok; Choi, Chang-min | Univ Ulsan, Asan Med Ctr, Coll Med, Div Pulmonol & Crit Care Med,Dept Internal Med, 88 Olymp ro 43-gil, Seoul 05505, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Dept Oncol, Seoul 05505, South Korea; Chonnam Natl Univ, Med Sch, Dept Internal Med, Jeollanamdo 58128, South Korea; Hwasun Hosp, Gwangju 58128, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Div Pulm & Crit Care Med,Coll Med,Dept Internal Me, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Yangsan 50612, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Taegu 41404, South Korea; Pusan Natl Univ Hosp, Dept Internal Med, Div Pulmonol Allergy & Crit Care Med, Pusan 49241, South Korea; Chungnam Natl Univ, Dept Internal Med, Div Pulmonol, Daejeon 34134, South Korea; Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Internal Med,Div Pulm Allergy & Crit Care Med, Seoul 16247, South Korea; Konkuk Univ, Med Ctr, Sch Med, Dept Internal Med, Seoul 05030, South Korea; Korea Univ, Guro Hosp, Coll Med, Div Pulm Allergy & Crit Care Med,Dept Internal Med, Seoul 08308, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Pulmonol, Seoul 16247, South Korea; Inha Univ Hosp, Dept Internal Med, Incheon 22332, South Korea | ; Oh, In-Jae/AAG-5919-2020; Lee, Jeong Eun/R-8689-2019; Lim, Jun Hyeok/ABA-5277-2021; Lee, Joo Yong/ADE-2110-2022; Kim, Eun-Young/GQQ-0147-2022; Lee, Yo Han/IUN-3410-2023 | 57909631600; 24825051600; 58754601500; 57361264500; 55479240500; 49863712700; 16433227400; 57209104622; 14623269200; 8720534800; 56734650000; 57225930594; 57214084476; 14024046800 | hyeonhwa1@gmail.com;jclee@amc.seoul.kr;droij@chonnam.ac.kr;dognose79@naver.com;leemk@pusan.ac.kr;ckpaul@catholic.ac.kr;kyleemd@kuh.ac.kr;cmcksj@catholic.ac.kr;ccm@amc.seoul.kr; | CANCERS | CANCERS | 2072-6694 | 16 | 3 | SCIE | ONCOLOGY | 2024 | 4.4 | 25.9 | 1.4 | 2025-05-07 | 3 | 3 | ROS1; non-small-cell lung cancer; crizotinib; real-world efficacy | KINASE INHIBITOR; PHASE-III; ROS1; SURVIVAL; MUTATION; GENE; ADENOCARCINOMA; REARRANGEMENT; RESISTANCE; CISPLATIN | crizotinib; non-small-cell lung cancer; real-world efficacy; ROS1 | anaplastic lymphoma kinase; CD74 antigen; crizotinib; epidermal growth factor receptor; adult; aged; Article; body height; body mass; body weight; cancer staging; central nervous system metastasis; clinical article; cohort analysis; cytology; data analysis; distant metastasis; drug efficacy; drug safety; drug tolerability; ECOG Performance Status; female; fluorescence in situ hybridization; gene mutation; gene rearrangement; high throughput sequencing; histology; histopathology; human; hypertransaminasemia; immunohistochemistry; liquid biopsy; lymph node biopsy; male; multicenter study; non small cell lung cancer; oncogene K ras; outcome assessment; overall response rate; overall survival; pathological complete response; pleura effusion; progression free survival; proto oncogene; real time reverse transcription polymerase chain reaction; ROS1 gene; sequence analysis; smoking; treatment response; tumor growth; very elderly | English | 2024 | 2024-02 | 10.3390/cancers16030528 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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