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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Convective MHD flow of hybrid-nanofluid within an elliptic porous enclosure | The essential aim of this modeling is to scrutinize the irreversibility and heat transfer of hybrid nanomaterial within a permeable medium. The inner elliptic surface experiences the uniform flux and outer wall maintains cold temperature. To scrutinize the impact of porous region, difference between the temperature of fluid and solid matrix was involved and stream function formulation was applied to simplify the equations. Outputs were obtained by means of CVFEM and its accuracy was check by comparing with previous article. Greater values for W can be obtained with rise of Ra while opposite tendency appears for Ha. When Nhs* = 1, Ha = 1, growth of Ra provides 3.86 times lower values of Nu. Nu declines about 70.1% with growth of Ha when Ra* = 5, Nhs* = 0.01. Unfavorable effect of MHD on Nu declines with augment of Nhs*. Nu reduces about 72.5% with augment of Nhs when Ra* = 5, Ha = 1. (C) 2020 Elsevier B.V. All rights reserved. | Shehzad, S. A.; Sheikholeslami, M.; Ambreen, T.; Shafee, Ahmad | COMSATS Univ Islamabad, Dept Math, Sahiwal 57000, Pakistan; Babol Noshirvani Univ Technol, Dept Mech Engn, Babol, Iran; Babol Noshirvani Univ Technol, Renewable Energy Syst & Nanofluid Applicat Heat T, Babol, Iran; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Duy Tan Univ, Inst Res & Dev, Da Nang 550000, Vietnam | Shafee, A./ABF-2812-2020; Sheikholeslami, Mohsen/G-9034-2015; Shehzad, Sabir/J-3885-2014 | 42262831200; 54880733100; 57195420431; 57202423343 | sabirali@cuisahiwal.edu.pk;shafeehajizadehahmad@duytan.edu.vn; | PHYSICS LETTERS A | PHYS LETT A | 0375-9601 | 1873-2429 | 384 | 28 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2020 | 2.654 | 41.3 | 2.35 | 2025-06-25 | 38 | 41 | Elliptic porous enclosure; Nano powders; Free convection; Magnetic forces | TANGENT HYPERBOLIC NANOFLUID; NATURAL-CONVECTION; THERMAL-CONDUCTIVITY; MAGNETIC-FIELD; MASS-TRANSFER; AGGREGATIONS; CAVITY | Elliptic porous enclosure; Free convection; Magnetic forces; Nano powders | Heat transfer; Cold temperatures; Elliptic surfaces; Fluid and solids; Hybrid nanofluid; Hybrid nanomaterials; Porous enclosure; Streamfunction formulation; Uniform flux; Magnetohydrodynamics | English | 2020 | 2020-10-09 | 10.1016/j.physleta.2020.126727 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ecological value of global terrestrial plants | As a crucial primary producer of the earth, terrestrial plants play important functions in energy flow and biogeochemical cycles of the planet. However, their real wealth contributions to human society are not properly evaluated because of their widespread distribution and limitations in evaluation methods. This study used the emergy methodology to evaluate the ecological economic value of global terrestrial plants. Terrestrial plants were divided into three groups of bryophytes, gymnosperms and angiosperms for the emergy evaluation. The area of the system boundary for terrestrial plants was 13.5 E+9 ha. Total annual emergy use of the terrestrial plants was 10.29 E + 24 sej yr(-1) which consisted of 9.19 E + 24 sej yr(-1) by angiosperms, 1.00 E + 24 sej yr(-1) used by gymnosperms, and 0.09 E + 24 sej yr(-1) by bryophytes. The total emergy stored in the terrestrial plants was 648.50 E + 24 sej, with 550.28 E + 24 sej stored in angiosperms, 91.64 E + 24 sej in gymnosperms, and 6.58E+24 sej in bryophytes. The Unit Emergy Values (UEVs) of the Net Primary Production (NPP) of terrestrial plants was calculated as 183.31 E + 6 sej gC(-1). For each plant group, UEVs were 189.00 E + 6 sej gC(-1) for angiosperms, 145.54 E + 6 sej J(-1) for gymnosperms, and 159.63 E + 06 sej gC(-1) for bryophytes. The emdollar values were calculated to determine approximate monetary values for production and storage of the terrestrial plants. The ecological values of the annual plant production were 5.14 trillion (em)$ for the all terrestrial plants with 4.59 trillion, 0.50 trillion, and 0.05 trillion (em)$ for angiosperm, gymnosperm, and bryophytes respectively. The ecological values stored in the plant biomasses were 324.25 trillion (em)$ for all the terrestrial plans, with 275.14 trillion, 45.82 trillion, and 3.29 trillion (em)$ for angiosperm, gymnosperm, and bryophytes respectively. | Lee, Dong Joo; Choi, Moon Bo | Gwangju Inst Sci & Technol, Sch Earth Sci & Environm Engn, Gwangju, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | 57208500119; 51863232400 | kosinchoi@hanmail.net; | ECOLOGICAL MODELLING | ECOL MODEL | 0304-3800 | 1872-7026 | 438 | SCIE | ECOLOGY | 2020 | 2.974 | 41.3 | 0.25 | 2025-06-25 | 4 | 3 | Ecological economic value; Terrestrial plant; Emergy analysis; UEV; NPP | NET PRIMARY PRODUCTION; ECOSYSTEM SERVICES; CLIMATE-CHANGE; BOREAL; COVER; PINE; SOIL; PRODUCTIVITY; BRYOPHYTES; EVOLUTION | Ecological economic value; Emergy analysis; NPP; Terrestrial plant; UEV | bryophytes; Gymnospermae; Magnoliophyta; Biogeochemistry; Earth (planet); Economics; Plants (botany); Biogeochemical cycle; Ecological economics; Ecological values; Emergy evaluation; Evaluation methods; Net primary production; Primary producers; Terrestrial plants; angiosperm; annual plant; biogeochemical cycle; bryophyte; ecological economics; energy flow; gymnosperm; terrestrial ecosystem; Ecology | English | 2020 | 2020-12-15 | 10.1016/j.ecolmodel.2020.109330 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Application of calcium nebulization for mass exposure to an accidental hydrofluoric acid spill | Purpose: To determine the long-term prevalence and characteristics of acute hydrofluoric acid (HF) exposure in 2223 patients during the first 30 months after a mass-casualty exposure, and to confirm the antidotal effect of nebulized calcium on inhalation burns caused by HF. Methods: This observational cohort study included patients after an HF spill in the Republic of Korea on September 27, 2012; registered patients were followed until April 2015. We assessed toxic effects, distance from spill, degree of acute poisoning, and the effect of nebulized calcium in HF-exposed individuals. Results: Overall, 2223 patients received emergency management or antidote therapy for 20 days. Seventy-four of 134 patients with dermal toxicity received calcium-lidocaine gel, and 368 individuals with bronchial irritation signs received calcium gluconate via nebulizer nCG. A total 377 ampoules 786 g of calcium gluconate were used in the nCG formulation. Calcium administration did not cause adverse reactions during the observation period. Longterm cohort observation showed that 120 patients (120/2233, 5.4%) returned to medical facilities for management of HF-related symptoms within 1 month; 18 persons (18/1660, 1.1%) returned 1-3 months later with chronic cough and respiratory symptoms; and 3 patients (3/1660, 0.2%) underwent medical treatment due to upper-airway toxic symptoms more than 2 years after HF exposure. Conclusion: Respiratory toxicity after mass exposure to an HF spill was successfully treated by calcium nebulizer. Based on our experience, detoxification processes and the amounts of antidote stocked are important when planning for future chemical disasters at the community level. (C) 2020 Elsevier Ltd and ISBI. All rights reserved. | Choe, Michael Sung Pil; Lee, Mi Jin; Seo, Kang Suk; Kam, Sin; Kim, Keon Yeop; Je, Dongwook; Kim, Seong Hun; Nho, Woo Young; Park, Hong In; Shin, Sujeong; Ryoo, Hyun Wook | CHA Univ, Gumi CHA Med Ctr, Dept Emergency Med, Gumi, South Korea; Kyungpook Natl Univ, Sch Med, Dept Emergency Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med & Publ Hlth, Daegu, South Korea | ; Nho, Woo Young/JLN-0752-2023 | 57189643732; 55507282600; 57204305189; 55764926800; 35076059600; 57215830267; 57215836673; 57215831839; 57215835549; 57215828708; 55350557500 | michaelchoe@hanmail.net;emmam@knu.ac.kr;kssuh@knu.ac.kr;kamshin@knu.ac.kr;pmkky@knu.ac.kr;jdw2000@daum.net;junram@nate.com;a345em@gmail.com;twilgiht2002@naver.com;drjeong79@naver.com;ryoo@knu.ac.kr; | BURNS | BURNS | 0305-4179 | 1879-1409 | 46 | 6 | SCIE | CRITICAL CARE MEDICINE;DERMATOLOGY;SURGERY | 2020 | 2.744 | 41.5 | 0.36 | 2025-06-25 | 7 | 4 | Burns; Chemical hazard release; Hydrofluoric acid; Calcium gluconate; Nebulizer | BURNS; DECONTAMINATION; ASSOCIATION; MANAGEMENT; COMMUNITY; GLUCONATE; EFFICACY | Burns; Calcium gluconate; Chemical hazard release; Hydrofluoric acid; Nebulizer | Administration, Cutaneous; Administration, Inhalation; Adolescent; Adult; Aged; Anesthetics, Local; Antidotes; Burns, Chemical; Burns, Inhalation; Calcium; Calcium Gluconate; Chemical Hazard Release; Child; Child, Preschool; Cohort Studies; Female; Gels; Humans; Hydrofluoric Acid; Infant; Infant, Newborn; Inhalation Exposure; Lidocaine; Male; Mass Casualty Incidents; Middle Aged; Nebulizers and Vaporizers; Republic of Korea; Young Adult; calcium; gluconate calcium; hydrofluoric acid; lidocaine; steroid; antidote; calcium; gluconate calcium; hydrofluoric acid; lidocaine; local anesthetic agent; adolescent; adult; aged; ambulatory care; Article; bronchitis; chemical burn; child; chronic cough; cohort analysis; diarrhea; disease course; disease severity; dizziness; drug safety; dyspnea; eye irritation; female; follow up; foreign body; headache; hemoptysis; human; hypochondriasis; infant; laryngitis; laryngopharyngitis; lung burn; lung toxicity; major clinical study; male; middle aged; monotherapy; myalgia; nausea; nebulization; newborn; observational study; patient safety; pharyngitis; pneumonia; rectum hemorrhage; skin irritation; skin toxicity; sore throat; South Korea; spillage; weakness; chemical accident; chemical burn; cutaneous drug administration; exposure; gel; inhalational drug administration; lung burn; mass disaster; nebulizer; preschool child; young adult | English | 2020 | 2020-09 | 10.1016/j.burns.2020.02.015 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Clinicopathological Features of Patients with the BRCA1 c.5339T>C (p.Leu1780Pro) Variant | Purpose Recent studies revealed the BRCA1 c.5339T>C, p.Leu1780Pro variant (L1780P) is highly suggested as a likely pathogenic. The aim of this study was to evaluate clinicopathologic features of L1780P with breast cancer (BC) using multicenter data from Korea to reinforce the evidence as a pathogenic mutation and to compare L1780P and other BRCA1/2 mutations using Korean Hereditary Breast Cancer (KOHBRA) study data. Materials and Methods The data of 54 BC patients with L1780P variant from 10 institutions were collected and the clinicopathologic characteristics of the patients were reviewed. The hereditary breast and/or ovarian cancer-related characteristics of the L1780P variant were compared to those of BC patients in the KOHBRA study. Results The median age of all patients was 38 years, and 75.9% of cases showed triple-negative breast cancer. Comparison of cases with L1780P to carriers from the KOHBRA study revealed that the L1780P patients group was more likely to have family history (FHx) of ovarian cancer (OC) (24.1% vs. 19.6% vs. 11.2%, p < 0.001 and p=0.001) and a personal history of OC (16.7% vs. 2.9% vs. 1.3%, p=0.003 and p=0.001) without significant difference in FHx of BC and bilateral BC. The cumulative risk of contralateral BC at 10 years after diagnosis was 31.9%, while the cumulative risk of OC at 50 years of age was 20.0%. Patients with L1780P showed similar features with BRCA1 carriers and showed higher penetrance of OC than patients with other BRCA1 mutations. Conclusion L1780P should be considered as a pathogenic mutation. Risk-reducing salpingo-oophorectomy is highly recommended for women with L1780P. | Park, Hyung Seok; Ryu, Jai Min; Park, Ji Soo; Im, Seock-Ah; Jung, So-Youn; Kim, Eun-Kyu; Park, Woo-Chan; Min, Jun Won; Lee, Jeeyeon; You, Ji Young; Lee, Jeong Eon; Kim, Sung-Won | Yonsei Univ, Coll Med, Dept Surg, Seoul, South Korea; Sungkyunkwan Univ, Samsung Comprehens Canc Ctr, Samsung Med Ctr, Dept Surg,Sch Med, Seoul, South Korea; Yonsei Canc Ctr, Canc Prevent Ctr, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Canc Res Inst, Seoul, South Korea; Natl Canc Ctr, Ctr Breast Canc, Goyang, South Korea; Seoul Natl Univ, Coll Med, Dept Surg, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Breast Care Ctr, Seongnam, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Dept Surg, Coll Med, Seoul, South Korea; Dankook Univ, Dept Surg, Coll Med, Cheonan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Surg, Daegu, South Korea; Korea Univ, Anam Hosp, Coll Med, Div Breast & Endocrine Surg,Dept Surg, Seoul, South Korea; Daerim St Marys Hosp, Breast Care Ctr, Dept Surg, 657 Siheung Daero, Seoul 07442, South Korea | ; Lee, Jeeyun/I-7171-2015; Park, Hong-Gyu/C-6000-2008; Kim, Sung-Won/J-5409-2012; Park, Ji Soo/JMR-4351-2023; Im, Seock-Ah/J-5620-2012; Kim, Eun-Kyu/LNQ-3974-2024; Lee, Jong-Mok/KVY-9550-2024 | 55713697800; 57158270000; 55271728100; 34570185300; 35272292400; 24829042700; 56067764000; 36182527600; 37079213100; 56692134000; 57200181799; 55974612200 | paojlus@hanmail.net;brcakorea@gmail.com; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 52 | 3 | SCIE | ONCOLOGY | 2020 | 4.679 | 41.5 | 0.47 | 2025-06-25 | 7 | 7 | Breast neoplasms; BRCA1; c.5339T > C; p.Leu1780Pro; Survival; Prognosis | HEREDITARY BREAST-CANCER; KOREAN PATIENTS; UNCLASSIFIED VARIANTS; ACMG STANDARDS; MUTATIONS; FOUNDER; GUIDELINES; GENES; RISK | Brca1; Breast neoplasms; C.5339tc; P.leu1780pro; Prognosis; Survival | Adult; Biomarkers, Tumor; BRCA1 Protein; Breast Neoplasms; Female; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Middle Aged; Mutation; Prognosis; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Republic of Korea; Retrospective Studies; BRCA1 protein; BRCA2 protein; leucine; proline; BRCA1 protein; BRCA1 protein, human; epidermal growth factor receptor 2; estrogen receptor; progesterone receptor; tumor marker; adult; age; Article; breast cancer; cancer prognosis; cancer survival; clinical feature; clinical outcome; estrogen receptor negative breast cancer; estrogen receptor positive breast cancer; event free survival; family history; female; gene mutation; hereditary breast and ovarian cancer syndrome; histopathology; human; human epidermal growth factor receptor 2 negative breast cancer; human epidermal growth factor receptor 2 positive breast cancer; Korea; major clinical study; medical history; multicenter study; ovary cancer; penetrance; prevalence; progesterone receptor negative breast cancer; progesterone receptor positive breast cancer; recurrence free survival; retrospective study; triple negative breast cancer; breast tumor; clinical trial; follow up; genetic predisposition; genetics; metabolism; middle aged; mutation; pathology; prognosis; South Korea | English | 2020 | 2020-07 | 10.4143/crt.2019.351 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Immunogenicity and Optimal Timing of 13-Valent Pneumococcal Conjugate Vaccination during Adjuvant Chemotherapy in Gastric and Colorectal Cancer: A Randomized Controlled Trial | Purpose Pneumococcal vaccination (13-valent pneumococcal conjugate vaccine [PCV13]) is recommended to cancer patients undergoing systemic chemotherapy. However, the optimal time interval between vaccine administration and initiation of chemotherapy has been little studied in adult patients with solid malignancies. Materials and Methods We conducted a prospective randomized controlled trial to evaluate whether administering PCV13 on the first day of chemotherapy is non-inferior to vaccinating 2 weeks prior to chemotherapy initiation. Patients were randomly assigned to two study arms, and serum samples were collected at baseline and 4 weeks after vaccination to analyze the serologic response against Streptococcus pneumoniae using a multiplexed opsonophagocytic killing assay. Results Of the 92 patients who underwent randomization, 43 patients in arm A (vaccination 2 weeks before chemotherapy) and 44 patients in arm B (vaccination on the first day of chemotherapy) were analyzed. Immunogenicity was assessed by geometric mean and fold-increase of post-vaccination titers, seroprotection rates (percentage of patients with post-vaccination titers > 1:64), and seroconversion rates (percentage of patients with > 4-fold increase in post-vaccination titers). Serologic responses to PCV13 did not differ significantly between the two study arms according to all three types of assessments. Conclusion The overall antibody response to PCV13 is adequate in patients with gastric and colorectal cancer during adjuvant chemotherapy, and no significant difference was found when patients were vaccinated two weeks before or on the day of chemotherapy initiation. | Choi, Wonyoung; Kim, Jong Gwang; Beom, Seung-Hawn; Hwang, Jun-Eul; Shim, Hyun-Jung; Cho, Sang-Hee; Shin, Min-Ho; Jung, Sin-Ho; Chung, Ik-Joo; Song, Joon Young; Bae, Woo Kyun | Chonnam Natl Univ, Coll Med, Dept Internal Med, Div Hematol Oncol,Hwasun Hosp, Hwasun, South Korea; Kyungpook Natl Univ, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Yonsei Univ, Dept Internal Med, Div Med Oncol, Coll Med, Seoul, South Korea; Chonnam Natl Univ, Dept Prevent Med, Med Sch, Hwasun, South Korea; Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA; Korea Univ, Dept Internal Med, Div Infect Dis, Coll Med, Seoul, South Korea | ; Kim, Sung-Bae/JXL-8219-2024; Choi, Wonyoung/ABE-3359-2020 | 55904980100; 34771414000; 52563182100; 57216575473; 57213652842; 56900205600; 7401537616; 7403677252; 15735604200; 57214400146; 14028001300 | infection@korea.ac.kr;drwookyun@jnu.ac.kr; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 52 | 1 | SCIE | ONCOLOGY | 2020 | 4.679 | 41.5 | 1.21 | 2025-06-25 | 17 | 22 | Chemotherapy; Vaccination; Stomach neoplasms; Colorectal neoplasms | ANTIBODY-RESPONSE; POLYSACCHARIDE VACCINE; INFLUENZA-VIRUS; CHILDREN; DISEASE; SAFETY | Chemotherapy; Colorectal neoplasms; Stomach neoplasms; Vaccination | Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colonic Neoplasms; Colorectal Neoplasms; Female; Humans; Immunization Schedule; Immunogenicity, Vaccine; Male; Middle Aged; Outcome Assessment, Health Care; Pneumococcal Infections; Pneumococcal Vaccines; Seroconversion; Seroepidemiologic Studies; Time-to-Treatment; Vaccination; antineoplastic agent; capecitabine; fluorouracil; folinic acid; gimeracil plus oteracil potassium plus tegafur; oxaliplatin; Pneumococcus vaccine; 13-valent pneumococcal vaccine; antineoplastic agent; Pneumococcus vaccine; adjuvant chemotherapy; adjuvant therapy; adult; aged; Article; bone marrow suppression; cancer combination chemotherapy; cancer immunization; cell killing; colorectal cancer; controlled study; drug dose reduction; female; human; major clinical study; male; neutropenia; optimal drug dose; phagocytosis; prospective study; randomized controlled trial; seroconversion; stomach cancer; Streptococcus pneumoniae; unspecified side effect; vaccine immunogenicity; adjuvant chemotherapy; adverse event; colon tumor; colorectal tumor; complication; immunization; immunology; middle aged; pneumococcal infection; procedures; seroepidemiology; time to treatment; vaccination | English | 2020 | 2020-01 | 10.4143/crt.2019.189 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Pediatric Adenocarcinoma in Korea: A Multicenter Study | Purpose Adenocarcinoma is an extremely rare malignancy in the pediatric population. Research regarding pediatric adenocarcinoma is very rare in Korea. This study aimed to investigate the clinical features of pediatric adenocarcinomas of various primary organ sites in Korea. Materials and Methods Pediatric patients under 18 years, diagnosed with adenocarcinoma of various sites between January 1995 and December 2016, were included. We retrospectively reviewed patient and tumor characteristics and calculated survival estimates, reported as 5-year survival rate and 95% confidence interval. Results Of 80 patients (median age, 15 years; range, 10 to 17 years), 37 (46.3%) were men, and 24 (30%) had a family history of cancer or underlying disease relevant to malignancy. The cancer locations were the colon and rectum (n=32), ovaries (n=18), stomach (n=15), lung (n=4), small bowel (n=1), and other sites (n=10). Totally, 54.8% patients (42/77) had stage 3 or 4 disease. The median follow-up period was 2.0 years (range, 0 to 20.4). The 5-year overall survival estimate for all patients, and for those with stomach, colorectal, ovarian, and other cancer sites were 57.9%+/- 11.5%, 58.2%+/- 25.7%, 41.5%+/- 18.2%, 87.5%+/- 16.2%, and 64.0%+/- 34.4%, respectively. The 5-year survival rate differed significantly between categories of adenocarcinomas into gastrointestinal (GI) (44.7%) and non-GI adenocarcinomas (78.8%) (p=0.007). The 5-year survival rate also differed significantly according to carcinoembryonic antigen level (69.3% in 3 ng/mL; p < 0.001). Conclusion In pediatric patients, adenocarcinomas arise from various organs and are often diagnosed at advanced stages. Large, prospective studies for their accurate clinical characteristics and prognostic factors are needed. | Yang, Hee-Beom; Namgoong, Jung-Man; Kim, Ki Hoon; Kim, Dae Yeon; Park, Jinyoung; Shin, Hyun Beak; Youn, Joong Kee; Lee, Sanghoon; Lee, Ji Won; Jung, Sung Eun; Chung, Jae Hee; Choe, Yun-Mee; Heo, Tae Gil; Ho, In Geol; Kim, Hyun-Young | Seoul Natl Univ, Dept Pediat Surg, Childrens Hosp, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Pediat Surg, Coll Med,Childrens Hosp, Seoul, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Surg, Coll Med, Busan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, Daegu, South Korea; Chonbuk Natl Univ, Dept Surg, Sch Med, Jeonju, South Korea; Sungkyunkwan Univ, Sch Med, Dept Surg, Samsung Med Ctr, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea; Seoul Natl Univ, Dept Pediat Surg, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Pediat Surg, Seoul, South Korea; Inha Sch Med, Dept Pediat Surg, Incheon, South Korea; Inje Univ, Ilsan Paik Hosp, Dept Surg, Goyang, South Korea; Yonsei Univ, Severance Childrens Hosp, Dept Pediat Surg, Coll Med, Seoul, South Korea | ; Kim, Ji/ABE-2824-2020; PARK, JUN-YOUNG/P-5981-2015; Jung, Sung/J-5641-2012 | 57210342570; 55073679300; 39361679400; 35292178400; 57190865032; 56060593200; 57189579452; 57202883546; 57217265353; 57193306322; 57207096724; 17134407300; 42761395500; 57189601203; 57192552961 | spkhy02@snu.ac.kr; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 52 | 1 | SCIE | ONCOLOGY | 2020 | 4.679 | 41.5 | 0.13 | 2025-06-25 | 2 | 2 | Adenocarcinoma; Pediatrics; Rare tumor | COLORECTAL-CARCINOMA; GASTRIC-CANCER; CHILDREN; ADOLESCENTS; CHILDHOOD; TUMORS; EXPERIENCE; SYMPTOMS; FEATURES; CLUES | Adenocarcinoma; Pediatrics; Rare tumor | Adenocarcinoma; Adolescent; Biomarkers, Tumor; Child; Combined Modality Therapy; Disease Management; Female; Humans; Male; Neoplasm Staging; Population Surveillance; Prognosis; Republic of Korea; Survival Analysis; Treatment Outcome; CA 19-9 antigen; capecitabine; carcinoembryonic antigen; cisplatin; doxifluridine; fluorouracil; folinic acid; irinotecan; oxaliplatin; paclitaxel; tumor marker; adolescent; Article; bile duct carcinoma; bladder carcinoma; bone marrow cancer; brain cancer; cancer chemotherapy; cancer localization; cancer radiotherapy; cancer staging; cancer survival; child; childhood cancer; clinical feature; colon adenocarcinoma; controlled study; family history; female; follow up; head and neck carcinoma; human; intestine carcinoma; Korea; lung adenocarcinoma; major clinical study; male; multicenter study; multimodality cancer therapy; nose cavity cancer; ovary adenocarcinoma; overall survival; pancreas adenocarcinoma; parotid gland cancer; rectum carcinoma; small intestine; spine cancer; stomach adenocarcinoma; survival rate; uterine cervix adenocarcinoma; adenocarcinoma; clinical trial; disease management; health survey; prognosis; South Korea; survival analysis; treatment outcome | English | 2020 | 2020-01 | 10.4143/crt.2019.092 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Real-World Experience of Nivolumab in Non-small Cell Lung Cancer in Korea | Purpose The introduction of immune checkpoint inhibitors represents a major advance in the treatment of lung cancer, allowing sustained recovery in a significant proportion of patients. Nivolumab is a monoclonal anti-programmed death cell protein 1 antibody licensed for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) after prior chemotherapy. In this study, we describe the demographic and clinical outcomes of patients with advanced NSCLC treated with nivolumab in the Korean expanded access program. Materials and Methods Previously treated patients with advanced nonsquamous and squamous NSCLC patients received nivolumab at 3 mg/kg every 2 weeks up to 36 months. Efficacy data including investigator-assessed tumor response, progression data, survival, and safety data were collected. Results Two hundred ninety-nine patients were treated across 36 Korean centers. The objective response rate and disease control rate were 18% and 49%, respectively; the median progression-free survival was 2.1 months (95% confidence interval [CI], 1.87 to 3.45), and the overall survival (OS) was 13.2 months (95% CI, 10.6 to 18.9). Patients with smoking history and patients who experienced immune-related adverse events showed a prolonged OS. Cox regression analysis identified smoking history, presence of immune-related adverse events as positive factors associated with OS, while liver metastasis was a negative factor associated with OS. The safety profile was generally comparable to previously reported data. Conclusion This real-world analysis supports the use of nivolumab for pretreated NSCLC patients, including those with an older age. | Lim, Sun Min; Kim, Sang-We; Cho, Byoung Chul; Kang, Jin Hyung; Ahn, Myung-Ju; Kim, Dong-Wan; Kim, Young-Chul; Lee, Jin Soo; Lee, Jong-Seok; Lee, Sung Yong; Park, Keon Uk; An, Ho Jung; Cho, Eun Kyung; Jang, Tae Won; Kim, Bong-Seog; Kim, Joo-Hang; Lee, Sung Sook; Na, Im-Il; Yoo, Seung Soo; Lee, Ki Hyeong | Yonsei Univ, Yonsei Canc Ctr, Div Med Oncol, Coll Med, Seoul, South Korea; Univ Ulsan, Coll Med, Div Oncol, Dept Internal Med,Asan Med Ctr, Seoul, South Korea; Catholic Univ Korea, Div Med Oncol, Dept Internal Med, Seoul St Marys Hosp,Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Div Hematol Oncol, Samsung Med Ctr, Sch Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Internal Med, Hwasun, South Korea; Natl Canc Ctr, Ctr Lung Canc, Goyang, South Korea; Seoul Natl Univ, Div Hematol & Med Oncol, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Korea Univ, Guro Hosp, Dept Internal Med, Seoul, South Korea; Keimyung Univ, Dongsan Hosp, Dept Hematol Oncol, Daegu, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Med Oncol,St Vincents Hosp, Suwon, South Korea; Gachon Univ, Dept Internal Med, Div Oncol, Gil Med Ctr, Incheon, South Korea; Kosin Univ, Dept Internal Med, Gospel Hosp, Busan, South Korea; Vet Hlth Serv Med Ctr, Dept Internal Med, Seoul, South Korea; CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Seongnam, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Hematol Oncol, Busan, South Korea; Korea Inst Radiol & Med Sci, Div Hematol Oncol, Dept Internal Med, Korea Canc Ctr Hosp, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Chungbuk Natl Univ, Coll Med, Chungbuk Natl Univ Hosp, Div Hematol Oncol,Dept Internal Med, 776 Ilsunhwan Ro, Cheongju 28644, South Korea | Lee, Joo Yong/ADE-2110-2022; KIM, SUNJONG/JXN-0257-2024; Lee, Hyoungjin/GRR-7154-2022; Kim, Jin-Seok/AAK-5424-2020; Cho, ByoungChul/LSL-6088-2024; Kim, Dong-Wan/J-5391-2012; Kang, Jin Hyoung/KYQ-2256-2024; Kim, Yong-Joo/AAK-1840-2021; Lee, Jae/R-3643-2019 | 56446114500; 49061131600; 7401747804; 56656852000; 7103352186; 56189698600; 35201246200; 55675871400; 8622005400; 56734650000; 55898683500; 24466611800; 56909397000; 7102426031; 58304574800; 56488520200; 47761294800; 13606074500; 56479781600; 57196253114 | kihlee@chungbuk.ac.kr; | CANCER RESEARCH AND TREATMENT | CANCER RES TREAT | 1598-2998 | 2005-9256 | 52 | 4 | SCIE | ONCOLOGY | 2020 | 4.679 | 41.5 | 0.81 | 2025-06-25 | 15 | 16 | Non-small cell lung cancer; Anti-PD-1; Real-world date | ADVERSE EVENTS; CHECKPOINT INHIBITORS; EFFICACY; ASSOCIATION; DOCETAXEL | Anti-PD-1; Non-small cell lung cancer; Real-world data | alanine aminotransferase; anaplastic lymphoma kinase; antineoplastic agent; aspartate aminotransferase; epidermal growth factor receptor; nivolumab; programmed death 1 ligand 1; adult; advanced cancer; aged; Article; bone metastasis; brain metastasis; cancer chemotherapy; cancer control; cancer radiotherapy; cancer surgery; cancer survival; clinical outcome; computer assisted tomography; controlled study; decreased appetite; demography; diarrhea; drug efficacy; drug safety; dyspnea; endocrine disease; erythema; fatigue; female; gastrointestinal disease; human; immunohistochemistry; large cell carcinoma; liver metastasis; liver toxicity; lung adenocarcinoma; lung metastasis; lung toxicity; major clinical study; male; multicenter study; myalgia; non small cell lung cancer; overall survival; people by smoking status; pleura effusion; pneumonia; progression free survival; pruritus; rash; side effect; skin toxicity; smoking; South Korea; squamous cell lung carcinoma; treatment response time; university hospital | English | 2020 | 2020-10 | 10.4143/crt.2020.245 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | A functionalized nanocomposite adsorbent for the sequential removal of radioactive iodine and cobalt ions in aqueous media | The need for efficient remediation of the radioactive waste caused by undesirable nuclear accidents and overspending of radionuclides has gained worldwide attention, with extensive recent efforts made to protect the environment from radioactive contamination. Although various treatment processes for the removal of radionuclides and the purification of liquid waste have been reported, the development of a better decontamination method is still necessary for obtaining enhanced desalination performances. Herein, we report a dual-functional composite adsorbent composed of a cellulose acetate membrane as a solid support, gold nanoparticles (AuNPs), and a metal chelating agent which can potentially be used to efficiently remove radioactive iodine and cobalt. In the desalination experiments, the sorption membrane was able to remove cobalt ions rapidly in water. Isotherm data shows that approximately 180 Co2+ atoms were captured per AuNP. Next, the same material was used for the adsorption of iodide anions. Within a few minutes, more than 99% of radioactive iodine was removed even in the presence of other ion species. These findings clearly demonstrate that the desalination method presented in here provides a useful approach for the sequential removal of toxic metal and halogen species in aqueous media. | Park, Jung Eun; Shim, Ha Eun; Mushtaq, Sajid; Choi, Yong Jun; Jeon, Jongho | Kyungpook Natl Univ, Dept Appl Chem, Sch Appl Chem Engn, Daegu 41566, South Korea; Korea Atom Energy Res Inst, Adv Radiat Technol Inst, Jeongeup 56212, South Korea; Pakistan Inst Engn & Appl Sci, Dept Nucl Engn, Islamabad 45650, Pakistan; Univ Seoul, Sch Environm Engn, Seoul 02504, South Korea | 57210160353; 56622211200; 57207516170; 57111090300; 35082028100 | jeonj@knu.ac.kr; | KOREAN JOURNAL OF CHEMICAL ENGINEERING | KOREAN J CHEM ENG | 0256-1115 | 1975-7220 | 37 | 12 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;ENGINEERING, CHEMICAL | 2020 | 3.309 | 41.6 | 0.31 | 2025-06-25 | 9 | 9 | Desalination; Composite Materials; Nanoadsorbents; Radioactive Wastes; Adsorption | NANOPARTICLES; EFFICIENT; NTA | Adsorption; Composite Materials; Desalination; Nanoadsorbents; Radioactive Wastes | English | 2020 | 2020-12 | 10.1007/s11814-020-0668-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Biochemical properties and crystal structure of formate-tetrahydrofolate ligase from Methylobacterium extorquens CM4 | Methylobacterium extorquens is a methylotroph model organism that has the ability to assimilate formate using the tetrahydrofolate (THF) pathway. The formate-tetrahydrofolate ligase from M. extorquens (MeFtfL) is an enzyme involved in the THF pathway that catalyzes the conversion of formate, THF, and ATP into formyltetrahydrofolate and ADP. To investigate the biochemical properties of MeFtfL, we evaluated the metal usage and enzyme kinetics of the enzyme. MeFtfL uses the Mg ion for catalytic activity, but also has activity for Mn and Ca ions. The enzyme kinetics analysis revealed that Km value of farmate was much higher than THF and ATP, which shows that the ligation activity of MeFtfL is highly dependent on formation concentration. We also determined the crystal structure of MeFtfL at 2.8 A resolution. MeFtfL functions as a tetramer, and each monomer consists of three domains. The structural superposition of MeFtfL with FtfL from Moorella thermoacetica allowed us to predict the substrate binding site of the enzyme. (C) 2020 Elsevier Inc. All rights reserved. | Kim, Seongmin; Lee, Seul Hoo; Seo, Hogyun; Kim, Kyung-Jin | Kyungpook Natl Univ, Sch Life Sci, KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Daegu 41566, South Korea; Pohang Univ Sci & Technol, Pohang Accelerator Lab, Pohang 37673, South Korea | Kim, Kyung-Jin/MVY-3405-2025 | 57204760454; 57205261937; 57189697998; 55510867400 | kkim@knu.ac.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 528 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2020 | 3.575 | 41.6 | 0.21 | 2025-06-25 | 7 | 7 | Formate assimilation; Methylobacterium extorquens CM4; Formate-tetrahydrofolate ligase; Metal usage | C1 COMPOUNDS; MICROBIAL-GROWTH; FORMYLTETRAHYDROFOLATE SYNTHETASE; METHYLOTROPHIC METABOLISM; GENOME SEQUENCES; METHANOL; C-1; AM1; PATHWAY; ENZYME | Formate assimilation; Formate-tetrahydrofolate ligase; Metal usage; Methylobacterium extorquens CM4 | Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Formate-Tetrahydrofolate Ligase; Formates; Kinetics; Metabolic Networks and Pathways; Methylobacterium extorquens; Models, Molecular; Protein Interaction Domains and Motifs; Protein Structure, Quaternary; Recombinant Proteins; calcium ion; formate tetrahydrofolate ligase; magnesium ion; manganese; bacterial protein; formate tetrahydrofolate ligase; formic acid; formic acid derivative; recombinant protein; Article; bacterial strain; binding site; biochemical analysis; crystal structure; crystallization; enzyme activity; enzyme analysis; enzyme purification; enzyme structure; enzyme substrate; Methylobacterium extorquens; nonhuman; priority journal; protein expression; chemistry; enzyme active site; enzymology; genetics; kinetics; metabolism; Methylobacterium extorquens; molecular model; protein domain; protein quaternary structure; X ray crystallography | English | 2020 | 2020-07-30 | 10.1016/j.bbrc.2020.05.198 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Biochemical properties and crystal structure of isocitrate lyase from Bacillus cereus ATCC 14579 | The glyoxylate cycle is an important anabolic pathway and acts under a C-2 compound (such as acetic acid) rich condition in bacteria. The isocitrate lyase (ICL) enzyme catalyzes the first step in the glyoxylate cycle, which is the cleavage of isocitrate to glyoxylate and succinate. This enzyme is a metalo-enzyme that contains an Mg2+ or a Mn(2+)ion at the active site for enzyme catalysis. We expressed and purified ICL from Bacillus cereus (BcICL) and investigated its biochemical properties and metal usage through its enzyme activity and stability with various divalent metal ion. Based on the results, BcICL mainly utilized the Mg2+ ion for enzyme catalysis as well as the Mn2+, Ni2+ and Co2+ ions. To elucidate its molecular mechanisms, we determined the crystal structure of BcICL at 1.79 angstrom. Through this structure, we analyzed a tetrameric interaction of the protein. We also determined the BcICL structure in complex with both the metal and its products, glyoxylate and succinate at 2.50 angstrom resolution and revealed each ligand binding modes. (C) 2020 Elsevier Inc. All rights reserved. | Lee, Seul Hoo; Ki, Dongwoo; Kim, Sangwoo; Kim, Il-Kwon; Kim, Kyung-Jin | Kyungpook Natl Univ, Sch Life Sci, KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Daegu 41566, South Korea | Kim, Kyung-Jin/MVY-3405-2025 | 57205261937; 57219308133; 59237076700; 56547774100; 55510867400 | kkim@knu.ac.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 533 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2020 | 3.575 | 41.6 | 0.21 | 2025-06-25 | 4 | 4 | Isocitrate lyase; Bacillus cereus; Metal utilization; Crystal structure | BACILLUS-CEREUS; BINDING-AFFINITY; GLYOXYLATE CYCLE; POTENTIAL TARGET; STABILITY | Bacillus cereus; Crystal structure; Isocitrate lyase; Metal utilization | Bacillus cereus; Catalytic Domain; Crystallography, X-Ray; Glyoxylates; Isocitrate Lyase; Magnesium; Metals; Models, Molecular; Protein Multimerization; Sequence Alignment; Sequence Analysis, Protein; Succinic Acid; cobalt; glyoxylic acid; isocitrate lyase; magnesium ion; metal ion; nickel; succinic acid; tetramer; glyoxylic acid; glyoxylic acid derivative; isocitrate lyase; magnesium; metal; succinic acid; Article; Bacillus cereus; biochemistry; catalysis; controlled study; crystal structure; crystallization; enzyme activity; enzyme analysis; enzyme binding; enzyme purification; enzyme stability; enzyme structure; nonhuman; priority journal; protein expression; Bacillus cereus; chemistry; enzyme active site; enzymology; metabolism; molecular model; protein multimerization; sequence alignment; sequence analysis; X ray crystallography | English | 2020 | 2020-12-17 | 10.1016/j.bbrc.2020.09.136 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Crumbs proteins regulate layered retinal vascular development required for vision | Crumbs proteins are transmembrane proteins that regulate cellular apico-basal polarity. Animals carrying mutated crb1 present retinal vascular abnormalities; this mutation is associated with progressive retinal degeneration with intraretinal cystoid fluid collection in humans. This study aimed to evaluate a potential role of crumbs proteins in retinal vascular development and maintenance. We demonstrated that crumbs homologues (CRBs) were differentially expressed and changed dramatically during mouse retinal vascular development. Intravitreal injection of CRB1 and CRB2 siRNA induced delayed development of the deep capillary plexus and premature development of the intermediate capillary plexus, resulting in disrupted vascular integrity. However, microfluidic chip assay using human retinal endothelial cells revealed that CRBs do not directly affect in vitro retinal angiogenesis. CRBs control retinal angiogenesis by regulating neuroglial vascular endothelial growth factor-A (VEGFA) and matrix metalloproteinase-3 expression. These findings demonstrate a pivotal role of CRBs in providing critical neurotrophic support through normal layered vascular network development and maintenance. This implies that preserving CRBs and restoring layered retinal vascular networks could be novel targets for preventing vision-threatening retinal diseases. (C) 2019 Elsevier Inc. All rights reserved. | Son, Sunggeun; Cho, Minsub; Lee, Junyeop | Yeungnam Univ, Dept Ophthalmol, Coll Med, 170 Hyeonchung Ro, Daegu 421415, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea | ; Lee, Junyeop/K-4940-2016 | 57211939747; 57222282298; 35071403300 | retina@yu.ac.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 521 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2020 | 3.575 | 41.6 | 0.63 | 2025-06-25 | 10 | 10 | Crumbs protein; Retina. angiogenesis; Deep vascular complex; Muller glia cell | PHOTORECEPTOR MORPHOGENESIS; GROWTH-FACTOR; CRB1; METALLOPROTEINASES; COMPLEX; VEGF | Crumbs protein; Deep vascular complex; Müller glia cell; Retina. angiogenesis | Animals; Animals, Newborn; Cells, Cultured; Electroretinography; Endothelial Cells; Eye Proteins; Gene Expression Regulation, Developmental; Humans; Matrix Metalloproteinase 3; Membrane Proteins; Mice, Inbred C57BL; Mice, Mutant Strains; Neovascularization, Physiologic; Nerve Tissue Proteins; Retina; Retinal Vessels; Vascular Endothelial Growth Factor A; CRB1 protein, human; Crb1 protein, mouse; Crb2 protein, mouse; eye protein; membrane protein; Mmp3 protein, mouse; nerve protein; stromelysin; vasculotropin A; angiogenesis; animal; C57BL mouse; cell culture; cytology; drug effect; electroretinography; endothelium cell; gene expression regulation; genetics; growth, development and aging; human; metabolism; mutant mouse strain; newborn; pathology; retina; retina blood vessel | English | 2020 | 2020-01-22 | 10.1016/j.bbrc.2019.11.013 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Crystal structure of an acetyl-CoA acetyltransferase from PHB producing bacterium Bacillus cereus ATCC 14579 | Bacillus cereus ATCC 14579 is a known polyhydroxybutyrate (PHB)-producing microorganism that possesses genes associated with PHB synthesis such as PhaA, PhaB, and PHA synthases. PhaA (i.e., thiolase) is the first enzyme in the PHA biosynthetic pathway, which catalyze the condensation of two acetyl-CoA molecules to acetoacetyl-CoA. Our study elucidated the crystal structure of PhaA in Bacillus cereus ATCC 14579 (BcTHL) in its apo- and CoA-bound forms. BcTHL adopts a type II biosynthetic thiolase structure by forming a tetramer. The crystal structure of CoA-complexed BcTHL revealed that the substrate binding site of BcTHL is constituted by different residues compared with other known thiolases. Our study also revealed that Arg221, a residue involved in ADP binding, undergoes a positional conformational change upon the binding of the CoA molecule. (C) 2020 Elsevier Inc. All rights reserved. | Hong, Jiyeon; Park, Woojin; Seo, Hogyun; Kim, Il-Kwon; Kim, Kyung-Jin | Kyungpook Natl Univ, Sch Life Sci, KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Daegu 41566, South Korea | ; Kim, Kyung-Jin/MVY-3405-2025 | 57205354591; 57211680374; 57189697998; 56547774100; 55510867400 | kkim@knu.ac.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 533 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2020 | 3.575 | 41.6 | 0.42 | 2025-06-25 | 10 | 9 | Bacillus cereus; Acetyl-CoA acetyltransferase; Polyhydroxybutyrate | POLYHYDROXYALKANOATE SYNTHASES; BIOSYNTHESIS; CLONING | Acetyl-CoA acetyltransferase; Bacillus cereus; Polyhydroxybutyrate | Acetyl-CoA C-Acetyltransferase; Bacillus cereus; Bacterial Proteins; Catalytic Domain; Coenzyme A; Crystallography, X-Ray; Hydroxybutyrates; Models, Molecular; acetyl coenzyme A acetyltransferase; adenosine diphosphate; butyric acid derivative; polyhydroxybutyrate; protein PhaA; unclassified drug; acetyl coenzyme A acetyltransferase; bacterial protein; coenzyme A; hydroxybutyric acid; Article; Bacillus cereus; binding site; conformational transition; controlled study; crystal structure; enzyme structure; enzyme substrate complex; enzyme synthesis; nonhuman; priority journal; protein structure; site directed mutagenesis; Bacillus cereus; chemistry; enzyme active site; enzymology; metabolism; molecular model; X ray crystallography | English | 2020 | 2020-12-10 | 10.1016/j.bbrc.2020.09.048 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Dach1 regulates neural crest migration during embryonic development | Dachshund 1(Dach1) is a key component of the retinal determination gene network that plays significant roles in cell fate regulation. The vertebrate homolog of Drosophila dachshund has gained considerable importance as an essential regulator of development, but its functions during embryonic development remain elusive. We investigated the functional significance of dach1 during Xenopus embryogenesis using loss-of-function studies. Reverse transcription-polymerase chain reaction demonstrated the maternal nature of dach1, showing enhanced expression at the neurula stage of development, and morpholino oligonucleotide injection of dach1 induced phenotypic anomalies of microcephaly and reduced body length. Animal cap assays followed by whole-mount in-situ hybridization indicated the perturbed expression of neural and neural crest (NC) markers. Our data suggest the prerequisite functions of dach1 in NC migration during Xenopus embryogenesis. However, the developmental pathways regulated by dach1 during embryogenesis require further elucidation. (C) 2020 Elsevier Inc. All rights reserved. | Kim, Yoo-Kyung; Lee, Hongchan; Ismail, Tayaba; Kim, Youni; Lee, Hyun-Shik | Kyungpook Natl Univ, Coll Nat Sci, KNU Ctr Nonlinear Dynam, Sch Life Sci,CMRI,BIC21 Plus KNU Creat BioRes Grp, Daegu 41566, South Korea | Ismail, Tayaba/LPQ-9181-2024 | 57207442979; 57210948333; 57190277495; 57204943696; 16316010200 | leeh@knu.ac.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 527 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2020 | 3.575 | 41.6 | 0.07 | 2025-06-25 | 6 | 4 | Dachshund; Neural crest; Neural development; Embryogenesis; Cell fate | TRANSCRIPTION FACTOR; MOUSE DACH1; EYE; SPECIFICATION; EXPRESSION; DACHSHUND; HOMOLOG; CHICK; LIMB; FGF | Cell fate; Dachshund; Embryogenesis; Neural crest; Neural development | Animals; Embryonic Development; Gene Deletion; Gene Expression Regulation, Developmental; Microcephaly; Neural Crest; Xenopus laevis; morpholino oligonucleotide; adult; animal experiment; animal tissue; Article; body size; controlled study; dachshund homolog 1 gene; embryo; embryo development; female; gene; gene expression; gene function; genetic regulation; in situ hybridization; loss of function mutation; microcephaly; neural crest; neural crest migration; neurulation; nonhuman; phenotype; priority journal; reverse transcription polymerase chain reaction; whole mount in situ hybridization; Xenopus laevis; animal; embryo development; embryology; gene deletion; gene expression regulation; genetics; metabolism; microcephaly; neural crest; pathology | English | 2020 | 2020-07-05 | 10.1016/j.bbrc.2020.05.009 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Down-regulation of IDH2 sensitizes cancer cells to erastin-induced ferroptosis | Ferroptosis is a form of regulated cell death induced by lipid peroxidation that is dependent on iron. This pathway is being considered as an alternative anticancer therapeutic strategy, and the chemoreagent erastin induces ferroptosis by blocking system Xc(-), which causes a cysteine shortage that depletes intracellular GSH. Mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2) is major enzyme that produces NADPH, which is a crucial source for mitochondrial GSH turnover. Therefore, we hypothesized that down-regulation of IDH2 would have a synergic effect on erastin-induced ferroptosis. Here, we investigated the effect of IDH2 knockdown on ferroptosis in human HT1080 fibrosarcoma and murine Hepa1-6 hepatoma cells cultured in vitro as well as in an in vivo model of allografted Hepa1-6 cells in nude mice. Our results show that susceptibility to ferroptosis was substantially increased when IDH2 was down-regulated. This study supports that IDH2 has protective effect against ferroptotic cell death, and that the enzyme could be targeted to sensitize cancer cells to ferroptosis. (C) 2020 Elsevier Inc. All rights reserved. | Kim, Hyunjin; Lee, Jin Hyup; Park, Jeen-Woo | Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, BK21 Plus KNU Creat BioRes Grp, Taegu, South Korea; Korea Univ, Dept Food & Biotechnol, Sejong, South Korea | park, jun yeon/GPX-5293-2022 | 57206212088; 36067819400; 35574514000 | parkjw@knu.ac.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 525 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2020 | 3.575 | 41.6 | 1.69 | 2025-06-25 | 36 | 40 | Ferroptosis; IDH2; Erastin; Sensitization | MITOCHONDRIAL; DAMAGE | Erastin; Ferroptosis; IDH2; Sensitization | Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regulation; Ferroptosis; Fibrosarcoma; Gene Knockdown Techniques; Humans; Isocitrate Dehydrogenase; Mice; Piperazines; isocitrate dehydrogenase 2; erastin; isocitrate dehydrogenase; isocitrate dehydrogenase 2, human; isocitrate dehydrogenase 2, mouse; piperazine derivative; animal cell; animal experiment; animal model; animal tissue; Article; cancer cell; cancer cell culture; cell death; cell protection; controlled study; down regulation; ferroptosis; Hepa 1-6 cell line; HT-1080 cell line; human; human cell; in vitro study; in vivo study; mouse; nonhuman; priority journal; sensitization; animal; down regulation; drug effect; ferroptosis; fibrosarcoma; gene knockdown; genetics; liver cell carcinoma; pathology; tumor cell line | English | 2020 | 2020-04-30 | 10.1016/j.bbrc.2020.02.093 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor | Androgenetic alopecia (AGA) is a common genetic disorder, and a X-chromosomal locus that contains the androgen receptor (AR) and ectodysplasin A2 receptor (EDA2R) genes represents a major susceptibility locus for AGA. In our previous study, we reported that ectodysplasin-A2 (EDA-A2) induces apoptosis in cultured human hair follicle (HF) cells and promotes the regression of HFs in mice. However, the role of the EDA-A2/EDA2R in AGA remains unknown, as the causative gene in this pathway has not yet been identified and potential functional connections between EDA-A2 signaling and the androgen pathway remain unclear. In this study, we investigated the expression of EDA2R in balding HFs and matched with non-balding HFs. The EDA2R level was upregulated in the balding dermal papilla (DP) cells compared with non-balding DP cells derived from patients with AGA. However, EDA2R was strongly expressed in both balding and non-balding outer root sheath (ORS) cells. We screened EDA-A2-regulated genes in balding DP cells and identified dickkopf 1 (DKK-1) as catagen inducer during the hair cycle. The mRNA and protein expression levels of DKK-1 were both upregulated by EDA-A2. In addition, DKK-1 expression was induced by EDA-A2 both in cultured human HFs and in mouse HFs. Moreover, the EDA-A2-induced apoptosis of DP and ORS cells was reversed by the antibody-mediated neutralization of DKK-1. Collectively, our data strongly suggest that EDA-A2 induces DKK-1 secretion and causes apoptosis in HFs by binding EDA2R, which is overexpressed in the bald scalp. EDA-A2/EDA2R signaling could inhibit hair growth through DKK-1 induction, and an inhibitor of EDA-A2/EDA2R signaling may be a promising agent for the treatment and prevention of AGA. (C) 2020 Elsevier Inc. All rights reserved. | Kwack, Mi Hee; Jun, Mee Sook; Sung, Young Kwan; Kim, Jung Chul; Kim, Moon Kyu | Kyungpook Natl Univ, Sch Med, Dept Immunol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Kyungpook Natl Univ Hosp, Hair Transplantat Ctr, Daegu, South Korea | 6507685557; 7006544857; 55663365300; 57207436677; 57199748390 | go3004@knu.ac.kr; | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | BIOCHEM BIOPH RES CO | 0006-291X | 1090-2104 | 529 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS | 2020 | 3.575 | 41.6 | 0.28 | 2025-06-25 | 7 | 7 | EDA-A2; EDA2R; DKK-1; AGA; Dermal papilla | MALE PATTERN BALDNESS; ANDROGEN; PATHWAY; GROWTH; GENE | AGA; Dermal papilla; DKK-1; EDA-A2; EDA2R | Alopecia; Apoptosis; Cells, Cultured; Ectodysplasins; Hair Follicle; Humans; Intercellular Signaling Peptides and Proteins; Up-Regulation; Xedar Receptor; dickkopf 1 protein; ectodysplasin receptor; messenger RNA; neutralizing antibody; protein ectodysplasin A2; unclassified drug; DKK1 protein, human; ectodysplasin A; EDA protein, human; EDA2R protein, human; signal peptide; XEDAR receptor; animal experiment; animal model; apoptosis; Article; cell culture; clinical article; comparative study; controlled study; dermal papilla cell; epidermis cell; female; gene control; gene expression; hair growth; human; human cell; human tissue; male; male type alopecia; mouse; nonhuman; outer root sheath cell; priority journal; protein analysis; protein expression; protein secretion; signal transduction; skin cell; upregulation; alopecia; cytology; genetics; hair follicle; metabolism | English | 2020 | 2020-08-27 | 10.1016/j.bbrc.2020.06.098 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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