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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Preputial gland adenoma in a wild nutria (Myocastor coypus): a case report | Tumor incidence in wild mammals is reportedly very low. Wild nutria, a large rodent, is known to carry many infectious diseases, but rarely exhibits neoplastic diseases. We necropsied a male wild nutria and found a large nodular mass in the left inguinal region, adjacent to the penis. Histopathologically, the mass was diagnosed as preputial gland adenoma. Spontaneous preputial gland adenomas are extremely rare in all animals. Moreover, reports of tumors in nutrias have been limited to adenocarcinomas of the lungs and uterus, as well as subcutaneous fibromas. Here, we describe preputial gland adenoma in a wild nutria. | Kong, Joo Yeon; Kim, Hyo-Seok; Yeon, Seong-Chan; Park, Jin-Kyu; Jeong, Kyu-Shik; Hong, Il-Hwa | Gyeongsang Natl Univ, Coll Vet Med, Dept Vet Pathol, 501 Jinju Daero, Jinju 52828, South Korea; Seoul Natl Univ, Coll Vet Med, Dept Vet Clin Sci, Seoul 08826, South Korea; Seoul Natl Univ, Coll Vet Med, Res Inst Vet Sci, Seoul 08826, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu 41566, South Korea; Gyeongsang Natl Univ, Inst Anim Med, Jinju 52828, South Korea | Jeong, Kyu-Shik/D-6740-2011 | 56575865600; 57204277409; 8953995900; 35213723500; 7201556460; 8702273100 | ihhong@gnu.ac.kr; | JOURNAL OF VETERINARY SCIENCE | J VET SCI | 1229-845X | 1976-555X | 21 | 1 | SCIE | VETERINARY SCIENCES | 2020 | 1.672 | 40.8 | 0.18 | 2025-06-25 | 0 | 1 | Adipophilin; nutria; preputial gland; sebaceous glands | LESIONS; MORPHOLOGY; MICE | Adipophilin; Nutria; Preputial gland; Sebaceous glands | Adenoma; Animals; Animals, Wild; Exocrine Glands; Genital Neoplasms, Male; Introduced Species; Male; Republic of Korea; Rodent Diseases; Rodentia; adenoma; animal; case report; exocrine gland; introduced species; male; male genital tract tumor; pathology; rodent; rodent disease; South Korea; veterinary medicine; wild animal | English | 2020 | 2020-01 | 10.4142/jvs.2020.21.e1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Xenon modulates the GABA and glutamate responses at genuine synaptic levels in rat spinal neurons | Effects of xenon (Xe) on whole-cell currents induced by glutamate (Glu), its three ionotropic subtypes, and GABA, as well as on the fast synaptic glutamatergic and GABAergic transmissions, were studied in the mechanically dissociated "synapse bouton preparation" of rat spinal sacral dorsal commissural nucleus (SDCN) neurons. This technique evaluates pure single or multi-synapse responses from native functional nerve endings and enables us to quantify how Xe influences pre- and postsynaptic transmissions accurately. Effects of Xe on glutamate (Glu)-, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-, kainate (KA)- and N-methyl-D-aspartate (NMDA)- and GABA(A) receptor-mediated whole-cell currents were investigated by the conventional whole-cell patch configuration. Excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) were measured as spontaneous (s) and evoked (e) EPSCs and IPSCs. Evoked synaptic currents were elicited by paired-pulse focal electric stimulation. Xe decreased Glu, AMPA, KA, and NMDA receptor-mediated whole-cell currents but did not change GABA(A) receptor-mediated whole-cell currents. Xe decreased the frequency and amplitude but did not affect the 1/e decay time of the glutamatergic sEPSCs. Xe decreased the frequency without affecting the amplitude and 1/e decay time of GABAergic sIPSCs. Xe decreased the amplitude and increased the failure rate (Rf) and paired-pulse ratio (PPR) without altering the 1/e decay time of both eEPSC and eIPSC, suggesting that Xe acts on the presynaptic side of the synapse. The presynaptic inhibition was greater in eEPSCs than in eIPSCs. We conclude that Xe decreases glutamatergic and GABAergic spontaneous and evoked transmissions at the presynaptic level. The glutamatergic presynaptic responses are the main target of anesthesia-induced neuronal responses. In contrast, GABAergic responses minimally contribute to Xe anesthesia. | Kubota, Hisahiko; Akaike, Hironari; Okamitsu, Nobuharu; Jang, Il-Sung; Nonaka, Kiku; Kotani, Naoki; Akaike, Norio | Saga Univ, Fac Med, Dept Pharmacol, 5-1-1 Nabeshima, Saga 8498501, Japan; Kumamoto Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 5-1 Oe Honmachi, Kumamoto 8620973, Japan; Hiroshima Inst Technol, Fac Engn, Dept Elect & Comp Engn, Saeki Ku, 2-1-1 Miyake, Hiroshima 7315193, Japan; Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, 2177 Dalgubeol Daero, Daegu 700412, South Korea; Kumamoto Hlth Sci Univ, Res Div Life Sci, Kita Ku, 325 Izumi Machi, Kumamoto 8615598, Japan; Kitamoto Hosp, Res Div Neurophysiol, 3-7-6 Kawarasone, Saitama 3430821, Japan; Med Corp, Res Div Clin Pharmacol, Juryo Grp, Kumamoto Kinoh Hosp,Kita Ku, 6-8-1 Yamamuro, Kumamoto 8608518, Japan | 7403029230; 25958914500; 57214445854; 7102177910; 9436836200; 56708285400; 57194502749 | akaike.sachin715@juryo.or.jp; | BRAIN RESEARCH BULLETIN | BRAIN RES BULL | 0361-9230 | 1873-2747 | 157 | SCIE | NEUROSCIENCES | 2020 | 4.079 | 40.8 | 0.73 | 2025-06-25 | 11 | 11 | Spinal neurons; Synaptic transmission; Xenon; Glutamate; GABA | D-ASPARTATE RECEPTOR; NMDA RECEPTOR; NITROUS-OXIDE; INHIBITORY TRANSMISSION; COMPETITIVE-INHIBITION; PRESYNAPTIC BOUTONS; ANESTHETICS; NEUROTRANSMISSION; CHANNELS; AMPA | GABA; Glutamate; Spinal neurons; Synaptic transmission; Xenon | Anesthetics, Inhalation; Animals; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Inhibitory Postsynaptic Potentials; Neurons; Presynaptic Terminals; Rats, Wistar; Synaptic Transmission; Xenon; 4 aminobutyric acid; 4 aminobutyric acid A receptor; alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid; glutamic acid; kainic acid; n methyl dextro aspartic acid; xenon; 4 aminobutyric acid; glutamic acid; inhalation anesthetic agent; xenon; animal experiment; animal tissue; Article; electrophysiology; electrostimulation; evoked response; excitatory postsynaptic potential; female; GABAergic transmission; male; nerve ending; nonhuman; presynaptic inhibition; priority journal; rat; spinal cord nerve cell; synaptic transmission; whole cell patch clamp; animal; drug effect; inhibitory postsynaptic potential; nerve cell; physiology; synaptic transmission; Wistar rat | English | 2020 | 2020-04 | 10.1016/j.brainresbull.2020.01.016 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Reusability of a single-walled carbon nanotube-based biosensor for detecting peanut allergens and Y. enterocolitica | Biosensing systems based on electrochemical detection is popular to the industrial community, because the electronic readout from biosensor assays could replace conventional microarray methods. However, the greatest practical barrier to a wider acceptance of biosensors within the industrial field is due to their associated manufacturing and operating costs. In this study, a single-walled carbon nanotube (SWCNT)-based biosensor was tested for reusability after cleaning. The reusability of the existing biosensing system was examined using diverse cleaning reagents. Successful sensor cleaning without affecting their reusable properties was confirmed using sodium hydroxide (NaOH) solution. A range of NaOH concentrations between 70 and 160 mM was tested and the optimum reusable concentration for the biosensor was determined as 100 mM. A 5-time-reuse of the biosensor was achieved using 100 mM NaOH solution for peanut allergen control. Furthermore, re-adding antiYersinia antibodies to the biosensor led to the reaction of bacterial cells of Yersinia enterocolitica with the potential biosensor response. Scanning electron microscopy (SEM) results showed that microorganisms (Y. enterocolitica) and peanut allergen (Ara hl) were washed away from the biosensor chip after washing using NaOH (100 mM) for 2 h. | Sobhan, Abdus; Oh, Jun-Hyun; Park, Mi-Kyung; Lee, Jinyoung | South Dakota State Univ, Dept Agr & Biosyst Engn, Brookings, SD 57006 USA; Sangmyung Univ, Dept Plant & Food Sci, 31 Sangmyungdae Gil, Cheonan Si 31066, Chungcheongnam, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, 80 Daehak Ro, Daegu 41566, South Korea; Sangmyung Univ, Gyedang Gen Educ Inst, 31 Sangmyungdae Gil, Cheonan Si 31066, Chungcheongnam, South Korea | Oh, Jun-Hyun/J-7704-2017; Sobhan, Abdus/AAD-5057-2022; Park, Mi-Kyung/J-9643-2017 | 38762116400; 36451213600; 7404491155; 57203144662 | dorgly@smu.ac.kr; | MICROELECTRONIC ENGINEERING | MICROELECTRON ENG | 0167-9317 | 1873-5568 | 225 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;NANOSCIENCE & NANOTECHNOLOGY;OPTICS;PHYSICS, APPLIED | 2020 | 2.523 | 40.9 | 0.95 | 2025-06-25 | 16 | 16 | Single-walled carbon nanotube; Biosensor; Reusability; Sodium hydroxide | REUSABLE ELECTROCHEMICAL BIOSENSOR; SENSITIVE DETECTION; DNA; IMMUNOSENSOR; REGENERATION | Biosensor; Reusability; Single-walled carbon nanotube; Sodium hydroxide | Allergens; Biosensors; Chemical detection; Cleaning; Nanotubes; Oilseeds; Operating costs; Reusability; Scanning electron microscopy; Sodium hydroxide; Biosensing systems; Biosensor response; ELectrochemical detection; Electronic readout; Industrial communities; NaOH concentration; Singlewalled carbon nanotube (SWCNT); Yersinia enterocolitica; Single-walled carbon nanotubes (SWCN) | English | 2020 | 2020-03-15 | 10.1016/j.mee.2020.111281 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A Comparative Evaluation of Physicochemical Properties and Photocatalytic Efficiencies of Cerium Oxide and Copper Oxide Nanofluids | Copper oxide (CuO) and cerium oxide (CeO2) of various concentrations have been prepared through an ultrasonically assisted dispersion of CuO and CeO2 nanoparticles (NPs) in which water and nanofluids (NFs) were formulated. The morphological properties of the CuO and CeO2 NPs are reported. Few of the physicochemical properties that can influence the photocatalytic activities of the NFs are evaluated, such as viscosity, activation energy, density, thermal conductivity, electrical conductivity, alternating current (AC) conductivity, pH, stability, refractive index and optical band gap of the CuO and CeO2 NFs. Viscosity studies have been made at four different temperatures (303 K, 308 K, 313 K and 318 K) and the activation energy is calculated and compared between the CuO and CeO2 NFs. The thermal conductivity of the two NFs is calculated and compared. Electrical conductivity is measured for CuO and CeO2 NFs using an impedance analyzer at different frequencies at 303 K. The dielectric constant and AC conductivity were studied. The electrical conductivity and pH of the prepared NFs are measured and the results are compared. The stability of the NFs is determined from Zeta potential values obtained from dynamic light scattering measurements. UV-Visible diffuse reflectance measurements were used to deduce the optical bandgap of the respective metal oxide NPs in the NFs. The photocatalytic efficiencies of the CuO NFs and CeO2 NFs were evaluated using methylene blue (MB) as the model dye. The rate constant for the photodegradation of MB was higher for CuO NF as compared CeO2 NF and also higher than simple NPs-based photocatalysts. A plausible explanation for the role of NFs over the simple NPs-based photocatalytic solution is presented. | Rashmi, M.; Padmanaban, R.; Karthikeyan, Vaithinathan; Roy, Vellaisamy A. L.; Gopalan, Anantha-Iyengar; Saianand, Gopalan; Kim, Wha-Jung; Kannan, Venkatramanan | SCSVMV Deemed Univ, Dept Phys, Kanchipuram 631561, India; St Josephs Coll Arts & Sci Women, Dept Phys, Hosur 635126, India; City Univ Hongkong, Dept Mat Sci & Engn, Hong Kong 999077, Peoples R China; Univ Glasgow, Dept Elect & Nanoscale Engn, Glasgow G12 8QQ, Lanark, Scotland; Kyungpook Natl Univ, Daeyong Reg Infrastruct Technol Dev Ctr, Daegu 41556, South Korea; Univ Newcastle, Fac Engn & Built Environm, Callaghan, NSW 2308, Australia | Karthikeyan, V/O-8594-2017; kannan, venkatramanan/N-4628-2016; VELLAISAMY, Arul Lenus Roy/NDY-9741-2025; Gopalan, Saianand/J-6000-2019; KARTHIKEYAN, V/O-8594-2017 | 57221910297; 55253788200; 55846904800; 7005870324; 57191999779; 38362265400; 57203533494; 57218952492 | mrashme@gmail.com;kv.rjpm@gmail.com;kvecers@gmail.com;roy.vellaisamy@glasgow.ac.uk;algopal99@gmail.com;SaiAnand.Gopalan@newcastle.edu.au;kimwj@knu.ac.kr;kv@kanchiuniv.ac.in; | CATALYSTS | CATALYSTS | 2073-4344 | 10 | 1 | SCIE | CHEMISTRY, PHYSICAL | 2020 | 4.146 | 41.1 | 0.84 | 2025-06-25 | 23 | 24 | nanofluids; conductivity; stability; optical band gap and photocatalyst | THERMAL-CONDUCTIVITY ENHANCEMENT; HEAT-TRANSFER ENHANCEMENT; ETHYLENE-GLYCOL; METHYLENE-BLUE; ELECTRICAL-CONDUCTIVITY; PHYSICAL-PROPERTIES; CUO NANOSTRUCTURES; ACTIVATION-ENERGY; HYDROGEN-PEROXIDE; CARBON NANOTUBES | Conductivity; Nanofluids; Optical band gap and photocatalyst; Stability | English | 2020 | 2020-01 | 10.3390/catal10010034 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Catalytic Technologies for CO Hydrogenation for the Production of Light Hydrocarbons and Middle Distillates | In South Korea, where there are no resources such as natural gas or crude oil, research on alternative fuels has been actively conducted since the 1990s. The research on synthetic oil is subdivided into Coal to Liquid (CTL), Gas to Liquid (GTL), Biomass to Liquid (BTL), etc., and was developed with the focus on catalysts, their preparation, reactor types, and operation technologies according to the product to be obtained. In Fischer-Tropsch synthesis for synthetic oil from syngas, stability, CO conversion rate, and product selectivity of catalysts depends on the design of their components, such as their active material, promoter, and support. Most of the developed catalysts were Fe- and Co-based catalysts and were developed in spherical and cylindrical shapes according to the reactor type. Recently, hybrid catalysts in combination with cracking catalysts were developed to control the distribution of the product. In this review, we survey recent studies related to the design of catalysts for production of light hydrocarbons and middle distillates, including hybrid catalysts, encapsulated core-shell catalysts, catalysts with active materials with well-organized sizes and shapes, and catalysts with shape- and size-controlled supports. Finally, we introduce recent research and development (R&D) trends in the production of light hydrocarbons and middle distillates and in the catalytic processes being applied to the development of catalysts in Korea. | Chae, Ho Jin; Kim, Jin-Ho; Lee, Soo Chool; Kim, Hyo-Sik; Jo, Seong Bin; Ryu, Jae-Hong; Kim, Tae Young; Lee, Chul Ho; Kim, Se Jeong; Kang, Suk-Hwan; Kim, Jae Chang; Park, Myung-June | Kyungpook Natl Univ, Res Inst Adv Energy Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem Engn, Daegu 41566, South Korea; Inst Adv Engn, Plant Engn Ctr, Yongin 17180, Gyeonggi Do, South Korea; Ajou Univ, Dept Chem Engn, Suwon 16499, Gyeonggi Do, South Korea; Ajou Univ, Dept Energy Syst Res, Suwon 16499, Gyeonggi Do, South Korea | ; Chae, Ho/C-5535-2011; Jung, Hee-Tae/C-1574-2011; Kim, Yu/L-8480-2017; Park, Myung-June/D-6465-2013; Jo, SeongBin/MFJ-9000-2025 | 57204090253; 52563650100; 8524020100; 56981364800; 57190754848; 20735661400; 57208461628; 57203804607; 57214129193; 8549491400; 55985396900; 7404491035 | hwman777@nate.com;jinho@iae.re.kr;soochool@knu.ac.kr;hyosgogo@iae.re.kr;santebin@knu.ac.kr;jhryu@iae.re.kr;tyoung0218@knu.ac.kr;cjfgh38@knu.ac.kr;sjkim@knu.ac.kr;shkang@iae.re.kr;kjchang@knu.ac.kr;mjpark@ajou.ac.kr; | CATALYSTS | CATALYSTS | 2073-4344 | 10 | 1 | SCIE | CHEMISTRY, PHYSICAL | 2020 | 4.146 | 41.1 | 0.53 | 2025-06-25 | 33 | 34 | syngas; Fischer-Tropsch; catalyst design; active metal size; acidic site control; hydrocarbons | FISCHER-TROPSCH SYNTHESIS; ZEOLITE CAPSULE CATALYST; SUPPORTED IRON CATALYSTS; PARTICLE-SIZE; FIXED-BED; ISOPARAFFIN SYNTHESIS; SUPERCRITICAL-FLUID; CARBON NANOTUBES; HYBRID CATALYSTS; MN PROMOTION | Acidic site control; Active metal size; Catalyst design; Fischer; Hydrocarbons; Syngas; Tropsch | English | 2020 | 2020-01 | 10.3390/catal10010099 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Monomeric and tetrameric mercury(II) complexes with iodo and N2O2/N3O ligands: Structure and blue luminescence | The reaction of mercury(II) iodide and potential tetradentate ligand N-(2-pyridylmethyl)iminodiethanol (H2pmide) or N,N-bis(2-pyridylmethyl)-2-aminoethanol (bpaeOH) leads to the isolation of monomeric complex [Hg(H(2)pmide)(I)(2)] (1) and tetrameric {[Hg-2(bpaeOH)(2)][Hg2I7]I} (2). The crystal structures of 1 and 2 have been characterized by single crystal X-ray crystallography. In mononuclear neutral complex 1, the Hg(II) ion is bonded with one H2pmide species and two iodide anions as a distorted square pyramidal structure. 2 is a tetranuclear neutral complex that is composed of two [Hg(bpaeOH)](2+) cations and one [Hg2I7](3-) anion as well as additional I- anion. The [Hg2I7](3-) species connected to both the [Hg(bpaeOH)](2+) and [Hg(bpaeOH)(I)](+) units on the opposite side, which gives rise to the tetranuclear structure. 1 shows strong fluorescent emission at 412 nm with a blue color in methanol solution, while 2 displays very weak emission at 467 nm in the solid state. Particularly, in the case of 1, quantum yield is ca. 8.1% and fluorescence decay lifetime is ca. 1.95 ns. | Cho, Minji; Shin, Hye Jin; Kusumahastuti, Dewi K. A.; Yeo, Hyeonuk; Min, Kil Sik | Kyungpook Natl Univ, Dept Chem Educ, Daegu 41566, South Korea | Yeo, Hyeonuk/AHE-0397-2022; Arum Kusumahastuti, Dewi Kurnianingsih/IQW-8936-2023; yeo, hyeonuk/G-7890-2017 | 57217131029; 57217093676; 57213368367; 55324816500; 7201466885 | minks@knu.ac.kr; | INORGANICA CHIMICA ACTA | INORG CHIM ACTA | 0020-1693 | 1873-3255 | 511 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR | 2020 | 2.545 | 41.1 | 0.41 | 2025-06-25 | 7 | 6 | Coordination complex; Mercury(II); Ligand; Crystal structure; Photoluminescence | ON FLUORESCENT SENSORS; TURN-ON; HALIDE-COMPLEXES; CRYSTAL; PHOTOLUMINESCENCE; LIQUID | Coordination complex; Crystal structure; Ligand; Mercury(II); Photoluminescence | Fluorescence; Ligands; Negative ions; Single crystals; X ray crystallography; Blue luminescence; Fluorescence decays; Fluorescent emission; Monomeric complexes; Pyramidal structures; Single crystal X-ray crystallography; Tetradentate ligands; Tetranuclear structure; Mercury compounds | English | 2020 | 2020-10-01 | 10.1016/j.ica.2020.119789 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Morphological and Optical Properties of Cobalt Ion-Modified ZnO Nanowires | In this study, we prepared cobalt (Co) ion-modified ZnO nanowires using hydrothermal synthesis with zinc acetate dehydrate and Co (II) acetate hydrate precursors in ethanol solutions. Their morphological and optical properties were investigated with varying Co precursor concentration. The morphological changes of the ZnO nanowires depended positively on the concentration of the Co precursor. The ZnO nanowires showed modified crystal orientations and nanostructure shapes depending on the Co concentration in the solutions. Variations in the optical properties of the Co ion-modified ZnO nanowires could be explained by the interaction of the Co ions with the band electrons, oxygen vacancies, and zinc interstitials. The overall growth and characteristics of ZnO nanowires synthesized in solutions containing low levels of Co ions were related to Co doping into the ZnO bulks. In solutions containing high levels of Co ions, these were additionally related to the Co oxide cluster. | Choi, Seok Cheol; Lee, Do Kyung; Sohn, Sang Ho | LG Elect, Dept Proc Dev, Gumi 3938, Gyeongsangbuk D, South Korea; Daegu Catholic Univ, Sch Adv Mat Sci & Chem Engn, Gyongsan 38430, Gyeongsangbuk D, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea | 59102851900; 55941000700; 7101646506 | jomi119@hanmail.net;dokyung@cu.ac.kr;shsohn@knu.ac.kr; | CATALYSTS | CATALYSTS | 2073-4344 | 10 | 6 | SCIE | CHEMISTRY, PHYSICAL | 2020 | 4.146 | 41.1 | 0.18 | 2025-06-25 | 4 | 4 | ZnO nanowire; cobalt ion modification; cobalt doping; hydrothermal method | NANORODS; NANOPARTICLES; PHOTOLUMINESCENCE; SEMICONDUCTORS; NITROGEN; GROWTH; FILMS | Cobalt doping; Cobalt ion modification; Hydrothermal method; ZnO nanowire | English | 2020 | 2020-06 | 10.3390/catal10060614 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Preparation of PP/2D-Nanosheet Composites Using MoS2/MgCl2- and BN/MgCl2-Bisupported Ziegler-Natta Catalysts | Polypropylene/molybdenum disulfied (PP/MoS2) and Polypropylene/hexagonal boron nitride (PP/hBN) nanocomposites with varying concentration (0-6 wt %) were fabricated via in situ polymerization using two-dimensional (2D)-nanosheet/MgCl2-supported Ti-based Ziegler-Natta catalysts, which was prepared through a novel coagglomeration method. For catalyst preparation and interfacial interaction, MoS(2)and hBN were modified with octadecylamine (ODA) and octyltriethoxysilane (OTES), respectively. Compared with those of pristine PP, thermal stability of composites was 70 degrees C higher and also tensile strength and Young's modulus of the composites were up to 35% and 60% higher (even at small filler contents), respectively. The alkyl-modified 2D nanofillers were characterized by strong interfacial interactions between the nanofiller and the polymer matrix. The coagglomeration method employed in this work allows easy introduction and content manipulation of various 2D-nanosheets for the preparation of 2D-nanosheet/MgCl2-supported Ti-based Ziegler-Natta catalysts. | Zhang, He-xin; Shin, Byeong-Gwang; Lee, Dong-Eun; Yoon, Keun-Byoung | Anhui Univ Technol, Sch Chem & Chem Engn, Maanshan 143032, Peoples R China; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, Daegu 41566, South Korea | ; Hexin, Zhang/ACI-3911-2022 | 25633288200; 57220731845; 56605563300; 7401607550 | hxzhang@ahut.edu.cn;bshin@naver.com;dolee@knu.ac.kr;kbyoon@knu.ac.kr; | CATALYSTS | CATALYSTS | 2073-4344 | 10 | 6 | SCIE | CHEMISTRY, PHYSICAL | 2020 | 4.146 | 41.1 | 0.24 | 2025-06-25 | 17 | 18 | boron nitride; MoS2; bisupported Ziegler-Natta catalysts; nanocomposites | HEXAGONAL BORON-NITRIDE; MECHANICAL-PROPERTIES; GRAPHENE; FUNCTIONALIZATION; NANOSHEETS; NANOCOMPOSITES; INTERCALATION; EXFOLIATION; PERFORMANCE; METAL | Bisupported Ziegler; Boron nitride; MoS<sub>2</sub> ; Nanocomposites; Natta catalysts | English | 2020 | 2020-06 | 10.3390/catal10060596 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Synthesis, structure, magnetic properties, and catecholase-like activity of a phenoxo bridged dinuclear cobalt(II) complex | A dinuclear cobalt complex Co2L2 (H2L = N,N'-bis(salicylidene)-2,2'-ethylenedianiline) have been synthesized and characterized. X-ray crystallography found that Co2L2 contains a planar Co2O2 core where two Co(II) ions are bridged by two phenoxo ligands with Co-Co distance of 3.221 angstrom and the coordination geometry of each cobalt(II) ion is a distorted trigonal bipyramid. The magnetic susceptibility measurements revealed that both Co (II) ions are in low-spin (S = 1/2) states and two Co(II) spin centers are antiferromagnetically coupled with the exchange coupling constant of J = -45 cm(-1). Co2L2 showed catecholase-like activity when 3,5-di-tert-butylcatechol (3,5-H(2)dtbc) was treated with Co2L2 in the presence of O-2 and NaOH with the turnover number of k(cat) = 803 h(-1). Electron paramagnetic resonance (EPR) on the reaction mixture observed a key reaction intermediates, 3,5-di-tert-butyl-1,2-benzosemiquinonate anion radical (3,5-dtsq(.-)) bound to Co(III)-center. This is the first time observation of Co(III)-3,5-dtsq(.-) intermediate during the oxidation of 3,5-H(2)dtbc by a dicobalt(II/II) complex. | Sarkar, Shuranjan; Lee, Hong-In | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Bangladesh Jute Res Inst, Chem Div, Dhaka 1207, Bangladesh | Lee, Hong-In/IXN-3185-2023; Sarkar, Shuranjan/AFT-0296-2022 | 36550566300; 8509535000 | 1eehi@knu.ac.kr; | INORGANICA CHIMICA ACTA | INORG CHIM ACTA | 0020-1693 | 1873-3255 | 504 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR | 2020 | 2.545 | 41.1 | 0.25 | 2025-06-25 | 4 | 4 | Cobalt complex; Dinuclear complex; Catecholase activity; Single crystal structure; Magnetic properties | COBALOXIME(II)-CATALYZED OXIDATIVE DEHYDROGENATION; PHENOXAZINONE SYNTHASE ACTIVITY; DICOPPER(II) COMPLEXES; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURES; NICKEL(II) COMPLEXES; HIGH-SPIN; CRYSTALLOGRAPHIC CHARACTERIZATION; MANGANESE(III) COMPLEXES; MACROCYCLIC FRAMEWORK | Catecholase activity; Cobalt complex; Dinuclear complex; Magnetic properties; Single crystal structure | Binary alloys; Crystal structure; Electron spin resonance spectroscopy; Ions; Magnetic properties; Magnetic susceptibility; Magnetism; Paramagnetic resonance; Reaction intermediates; Single crystals; Sodium hydroxide; X ray crystallography; Antiferro-magnetically coupled; Catecholase activity; Cobalt complexes; Dinuclear complex; Distorted trigonal bipyramid; Electron paramagnetic resonances (EPR); Exchange coupling constants; Magnetic susceptibility measurements; Cobalt compounds | English | 2020 | 2020-05-01 | 10.1016/j.ica.2020.119437 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue | The bark of Ulmus parvifolia Jacq. (UP) was traditionally used as a diuretic and to treat intestinal inflammation. With modern evidence of the correlation of diuretics, gut inflammation, and obesity, our study has shown the antiobesity effects of the bark of UP. UP treatment reduced lipid production and adipogenic genes in vitro. In vivo studies revealed that UP 100 mg/kg and UP 300 mg/kg treatment significantly reduced mouse weight without reducing food intake, indicating increased energy expenditure. UP significantly reduced the weight of epididymal and subcutaneous adipose tissue and decreased liver weight. Histological analysis revealed improvement in the progression of nonalcoholic fatty liver disease and epididymal white adipose tissue hypertrophy induced by a HFD. Real-Time PCR of epididymal adipose tissue revealed significant increases of uncoupling protein-1 (UCP-1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha) expression after UP 300 mg/kg treatments. Phosphorylation of AMP-activated protein alpha (AMPK alpha) was increased, while phosphorylation of Acetyl-CoA Carboxylase (ACC) was reduced. Our findings reveal the ability of UP to reduce the occurrence of obesity through increased browning of white adipose tissue via increased AMPK alpha, PPAR gamma, PGC-1 alpha, and UCP-1 expression. | Lee, Yuan Yee; Kim, Minki; Irfan, Muhammad; Yuk, Heung Joo; Kim, Dong-Seon; Lee, Seung Eun; Kim, Seung-Hyung; Kim, Suk; Kim, Sung-Dae; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu 41566, South Korea; Korea Inst Oriental Med, Herbal Med Res Div, Daejeon 34054, South Korea; Natl Inst Hort & Herbal Sci, Dept Herbal Crop Res, Chungbuk 27709, South Korea; Daejeon Univ, Inst Tradit Med & Biosci, Daejeon, South Korea; Gyeongsang Natl Univ, Coll Vet Med, Dept Vet Med, Jinju 52828, South Korea; Dongnam Inst Radiol & Med Sci, Res Ctr, Busan 46033, South Korea | ; Rhee, Man/O-5705-2016; Irfan, Muhammad/AAY-1961-2021; Yuk, Heung/T-5882-2019; Yuan Yee, Lee/ABH-8956-2022; Kim, Seung-Hyung/AAA-4707-2020 | 57203798815; 57199747297; 35069404400; 36969874600; 56947571300; 57219018706; 54383305300; 26651495500; 55156746000; 57211035357 | rheemh@knu.ac.kr;yuanyeelee@knu.ac.kr; | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | EVID-BASED COMPL ALT | 1741-427X | 1741-4288 | 2020 | SCIE | INTEGRATIVE & COMPLEMENTARY MEDICINE | 2020 | 2.63 | 41.1 | 0.28 | 2025-06-25 | 5 | 6 | NECROSIS-FACTOR-ALPHA; OBESITY; HYPERTENSION; INFLAMMATION; ADIPONECTIN; EXPRESSION; ADIPOKINES; REGULATOR; GINSENG; LEPTIN | 1 naphthalene sulfonic acid; 2 ethylacridine; 2(1h)naphthalenone; acetyl coenzyme A carboxylase; adiponectin; alanine aminotransferase; antiobesity agent; aspartate aminotransferase; catechin; catechin 7 o beta dextro apiofuranoside; CCAAT enhancer binding protein alpha; cholesterol; complement factor D; fatty acid binding protein 4; glucose; high density lipoprotein; leptin; low density lipoprotein; palmitic acid; peroxisome proliferator activated receptor gamma coactivator 1alpha; plant extract; sirtuin 1; sitosterol; somatomedin C; sterol regulatory element binding protein 1c; tetrahydrolipstatin; triacylglycerol; Ulmus parvifolia extract; unclassified drug; uncoupling protein 1; 3T3-L1 cell line; alanine aminotransferase blood level; animal experiment; animal model; animal tissue; antiobesity activity; Article; aspartate aminotransferase blood level; cell viability; cholesterol blood level; controlled study; diet-induced obesity; elm; energy expenditure; epididymis fat; food intake; freeze drying; glucose blood level; in vivo study; liver weight; male; mitochondrial biogenesis; mouse; nonalcoholic fatty liver; nonhuman; real time polymerase chain reaction; subcutaneous fat; thermogenesis; triacylglycerol blood level; Ulmus parvifolia; white adipose tissue | English | 2020 | 2020-12-23 | 10.1155/2020/9358563 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Autophagy pathway upregulation in a human iPSC-derived neuronal model of Cohen syndrome with VPS13B missense mutations | Significant clinical symptoms of Cohen syndrome (CS), a rare autosomal recessive disorder, include intellectual disability, facial dysmorphism, postnatal microcephaly, retinal dystrophy, and intermittent neutropenia. CS has been associated with mutations in the VPS13B (vacuolar protein sorting 13 homolog B) gene, which regulates vesicle-mediated protein sorting and transport; however, the cellular mechanism underlying CS pathogenesis in patient-derived neurons remains uncertain. This report states that autophagic vacuoles accumulate in CS fibroblasts and the axonal terminals of CS patient-specific induced pluripotent stem cells (CS iPSC)-derived neurons; additionally, autophagic flux was significantly increased in CS-derived neurons compared to control neurons. VPS13B knockout HeLa cell lines generated using the CRISPR/Cas9 genome editing system showed significant upregulation of autophagic flux, indicating that VSP13B may be associated with autophagy in CS. Transcriptomic analysis focusing on the autophagy pathway revealed that genes associated with autophagosome organization were dysregulated in CS-derived neurons. ATG4C is a mammalian ATG4 paralog and a crucial regulatory component of the autophagosome biogenesis/recycling pathway. ATG4C was significantly upregulated in CS-derived neurons, indicating that autophagy is upregulated in CS neurons. The autophagy pathway in CS neurons may be associated with the pathophysiology exhibited in the neural network of CS patients. | Lee, You-Kyung; Lee, Soo-Kyeong; Choi, Suin; Huh, Yang Hoon; Kwak, Ji-Hye; Lee, Yong-Seok; Jang, Deok-Jin; Lee, Jae-Hyung; Lee, Kyungmin; Kaang, Bong-Kiun; Lim, Chae-Seok; Lee, Jin-A | Hannam Univ, Dept Biol Sci & Biotechnol, 1646 Yuseongdaero, Daejeon 34054, South Korea; Korea Basic Sci Inst, Ctr Electron Microscopy Res, Daejeon 34133, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Dept Anat, Sch Med, Daegu 41944, South Korea; Seoul Natl Univ, Neurosci Res Inst, Dept Physiol Biomed Sci, Coll Med, Seoul 03080, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Ecol Sci, Sangju 37224, South Korea; Kyung Hee Univ, Sch Dent, Dept Life & Nanopharmaceut Sci, Dept Oral Microbiol, Seoul 02447, South Korea; Seoul Natl Univ, Coll Nat Sci, Dept Biol Sci, Seoul 08826, South Korea; Wonkwang Univ, Dept Pharmacol, Sch Med, 460 Iksan Daero, Iksan 54538, South Korea | Lee, Kyungmin/ABC-5624-2020; Kim, Young/T-8521-2019; Lee, Yong/J-5587-2012; Lee, Jae-Hyung/AAI-9813-2020 | 56651292200; 57216701289; 57195607367; 7102963459; 56689173300; 57049728800; 22234503100; 55690041500; 57211016316; 7003889686; 7403654010; 35337365000 | cslimwk1@wku.ac.kr;leeja@hnu.kr; | MOLECULAR BRAIN | MOL BRAIN | 1756-6606 | 13 | 1 | SCIE | NEUROSCIENCES | 2020 | 4.041 | 41.2 | 0.53 | 2025-06-25 | 10 | 11 | Cohen syndrome; Autophagy; VPS13B; iPSC | Autophagy; Cohen syndrome; iPSC; VPS13B | Autophagosomes; Autophagy; Autophagy-Related Proteins; Axons; Cysteine Endopeptidases; Developmental Disabilities; Fibroblasts; Fingers; Gene Knockout Techniques; HeLa Cells; Humans; Induced Pluripotent Stem Cells; Intellectual Disability; Microcephaly; Microscopy, Electron; Muscle Hypotonia; Mutation, Missense; Myopia; Nerve Net; Neurons; Obesity; Retinal Degeneration; Up-Regulation; Vacuoles; Vesicular Transport Proteins; ATG4C protein; cysteine proteinase; unclassified drug; ATG4A protein, human; autophagy related protein; cysteine proteinase; vesicular transport protein; VPS13B protein, human; Article; autophagosome; autophagy (cellular); autosomal recessive disorder; Cohen syndrome; controlled study; CRISPR-CAS9 system; electron microscopy; fibroblast; gene; gene editing; gene knockout; genetic association; HeLa cell line; human; human cell; induced pluripotent stem cell; missense mutation; nerve cell; nerve ending; polymerase chain reaction; priority journal; real time polymerase chain reaction; transcriptomics; upregulation; VPS13B gene; Western blotting; autophagy; axon; cell vacuole; developmental disorder; finger; genetics; intellectual impairment; metabolism; microcephaly; missense mutation; muscle hypotonia; myopia; nerve cell network; obesity; pathology; pathophysiology; physiology; retina degeneration; ultrastructure; upregulation | English | 2020 | 2020-05-06 | 10.1186/s13041-020-00611-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Identification of a novel Shank2 transcriptional variant in Shank2 knockout mouse model of autism spectrum disorder | Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders that are highly heterogeneous in clinical symptoms as well as etiologies. Mutations in SHANK2 are associated with ASD and accordingly, Shank2 knockout mouse shows ASD-like behavioral phenotypes, including social deficits. Intriguingly, two lines of Shank2 knockout (KO) mouse generated by deleting different exons (exon 6-7 or exon 7) showed distinct cellular phenotypes. Previously, we compared gene expressions between Shank2 KOs lacking exon 6-7 (e6-7 KO) and KOs lacking exon 7 (e7 KO) by performing RNA-seq. In this study, we expanded transcriptomic analyses to identify novel transcriptional variants in the KO mice. We found prominent expression of a novel exon (exon 4 ' or e4') between the existing exons 4 and 5 in the Shank2 e6-7 KO model. Expression of the transcriptional variant harboring this novel exon was confirmed by RT-PCR and western blotting. These findings suggest that the novel variant may function as a modifier gene, which contributes to the differences between the two Shank2 mutant lines. Furthermore, our result further represents an example of genetic compensation that may lead to phenotypic heterogeneity among ASD patients with mutations in the same gene. | Lee, Yong-Seok; Yu, Nam-Kyung; Chun, Jeewan; Yang, Jung-Eun; Lim, Chae-Seok; Kim, Hyopil; Park, Gaeun; Lee, Jin-A; Lee, Kyungmin; Kaang, Bong-Kiun; Lee, Jae-Hyung | Seoul Natl Univ, Neurosci Res Inst, Dept Physiol, Biomed Sci,Coll Med, Seoul 03080, South Korea; Seoul Natl Univ, Coll Nat Sci, Sch Biol Sci, Lab Neurobiol, Seoul 08826, South Korea; Kyung Hee Univ, Grad Sch, Dept Dent, Seoul 02447, South Korea; Wonkwang Univ, Dept Pharmacol, Sch Med, Iksan 54538, South Korea; Hannam Univ, Dept Biotechnol & Biol Sci, Daejeon 34430, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Dept Anat, Behav Neural Circuitry & Physiol Lab,Grad Sch Med, Daegu 41944, South Korea; Kyung Hee Univ, Sch Dent, Dept Life & Nanopharmaceut Sci, Dept Oral Microbiol, Seoul 02447, South Korea | ; Lee, Kyungmin/ABC-5624-2020; Lee, Jae-Hyung/AAI-9813-2020; Lee, Yong/J-5587-2012 | 57049728800; 23767421000; 56966122600; 56899164700; 7403654010; 57073489200; 57216310263; 35337365000; 57211016316; 7003889686; 55690041500 | kaang@snu.ac.kr;jaehlee@khu.ac.kr; | MOLECULAR BRAIN | MOL BRAIN | 1756-6606 | 13 | 1 | SCIE | NEUROSCIENCES | 2020 | 4.041 | 41.2 | 0.6 | 2025-06-25 | 13 | 13 | Autism spectrum disorder; RNA-seq; Shank2 | DNA METHYLATION; MUTANT MICE; BEHAVIORS; EXPRESSION; MUTATIONS; PROTEINS; SYNAPSE; GENE | Autism spectrum disorder; RNA-seq; Shank2 | Animals; Autism Spectrum Disorder; Brain; Exons; Gene Expression Regulation; Genome; Mice, Knockout; Nerve Tissue Proteins; RNA, Messenger; Transcription, Genetic; messenger RNA; messenger RNA; nerve protein; Shank2 protein, mouse; animal experiment; animal model; Article; autism; C57BL/6N mouse; controlled study; epigenetics; exon; gene; gene deletion; gene expression; gene function; gene identification; gene knockout; genetic association; genetic heterogeneity; genetic variability; human; male; modifier gene; mouse; mouse model; mRNA expression level; nonhuman; phenotype; priority journal; protein expression level; real time polymerase chain reaction; RNA sequence; Shank2 gene; transcriptomics; Western blotting; animal; autism; brain; gene expression regulation; genetic transcription; genetics; genome; knockout mouse; metabolism | English | 2020 | 2020-04-06 | 10.1186/s13041-020-00595-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Proteomic analysis of synaptic protein turnover in the anterior cingulate cortex after nerve injury | Synaptic proteins play an important role for the regulation of synaptic plasticity. Numerous studies have identified and revealed individual synaptic protein functions using protein overexpression or deletion. In neuropathic pain nociceptive stimuli conveyed from the periphery repetitively stimulate neurons in the central nerve system, brain and spinal cord. Neuronal activities change the turnover (synthesis and degradation) rate of synaptic proteins. Thus, the analysis of synaptic protein turnover rather than just expression level change is critical for studying the role of synaptic proteins in synaptic plasticity. Here, we analyzed synaptosomal proteome in the anterior cingulate cortex (ACC) to identify protein turnover rate changes caused by peripheral nerve injury. Whereas PKC gamma levels were not altered, we found that the protein's turnover rate decreased after peripheral nerve injury. Our results suggest that postsynaptic PKC gamma synthesized by neuronal activities in the ACC is translocated to the postsynaptic membrane with an extended half-life. | Ko, Hyoung-Gon; Park, Dong Ik; Lee, Ji Hyun; Turck, Christoph W.; Kaang, Bong-Kiun | Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Seoul Natl Univ, Coll Nat Sci, Dept Biol Sci, 1 Gwanangno, Seoul 08826, South Korea; Max Planck Inst Psychiat, Dept Translat Res Psychiat, Kraepelinstr 2, D-80804 Munich, Germany | Turck, Christoph/ADE-0191-2022; Ko, Hyoung-Gon/KQU-8680-2024 | 14522654800; 35764051800; 57203144576; 7005792344; 7003889686 | kaang@snu.ac.kr; | MOLECULAR BRAIN | MOL BRAIN | 1756-6606 | 13 | 1 | SCIE | NEUROSCIENCES | 2020 | 4.041 | 41.2 | 0.27 | 2025-06-25 | 4 | 4 | KINASE-C-GAMMA; POSTSYNAPTIC DENSITY; PKC-GAMMA; INVOLVEMENT | Animals; Gyrus Cinguli; Hippocampus; Male; Membrane Proteins; Mice; Nerve Tissue Proteins; Neuralgia; Neuronal Plasticity; Peripheral Nerve Injuries; Peroneal Nerve; Peroneal Neuropathies; Protein Kinase C; Protein Transport; Proteolysis; Proteomics; brain protein; protein kinase C gamma; synatic protein; unclassified drug; membrane protein; nerve protein; protein kinase C; protein kinase C gamma; animal experiment; animal model; anterior cingulate; Article; cell activity; controlled study; degranulation; gene translocation; male; mouse; nerve injury; neuropathic pain; nonhuman; peripheral nerve injury; phenotype; postsynaptic membrane; priority journal; protein analysis; protein blood level; protein expression; protein metabolism; proteomics; animal; biosynthesis; cingulate gyrus; hippocampus; injury; metabolism; nerve cell plasticity; neuralgia; pathophysiology; peroneal neuropathy; peroneus nerve; protein degradation; protein transport | English | 2020 | 2020-02-12 | 10.1186/s13041-020-0564-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The lateral habenula is critically involved in histamine-induced itch sensation | Lateral habenula (LHb) is a brain region acting as a hub mediating aversive response against noxious, stressful stimuli. Growing evidences indicated that LHb modulates aminergic activities to induce avoidance behavior against nociceptive stimuli. Given overlapped neural circuitry transmitting pain and itch information, it is likely that LHb have a role in processing itch information. Here, we examined whether LHb is involved in itchy response induced by histamine. We found that histamine injection enhances Fos (+) cells in posterior portion within parvocellular and central subnuclei of the medial division (LHbM) of the LHb. Moreover, chemogenetic suppression of LHbM reduced scratching behavior induced by histamine injection. These results suggest that LHb is required for processing itch information to induce histaminergic itchy response. | Ko, Hyoung-Gon | Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Seoul Natl Univ, Dept Biol Sci, Coll Nat Sci, 1 Gwanangno, Seoul 08826, South Korea | Ko, Hyoung-Gon/KQU-8680-2024 | 14522654800 | hgko@knu.ac.kr; | MOLECULAR BRAIN | MOL BRAIN | 1756-6606 | 13 | 1 | SCIE | NEUROSCIENCES | 2020 | 4.041 | 41.2 | 0.2 | 2025-06-25 | 3 | 3 | ACTIVATION; NEURONS; PAIN; PRURITUS; COWHAGE | Animals; Habenula; Histamine; Mice; Proto-Oncogene Proteins c-fos; Pruritus; Sensation; clozapine n oxide; histamine; histamine; protein c fos; animal cell; animal experiment; animal model; animal tissue; Article; atopic dermatitis; brain function; brain region; controlled study; habenula; immunohistochemistry; immunoreactivity; mouse; nerve cell; nonhuman; parvocellular reticular nucleus; priority journal; pruritus; sensation; animal; habenula; metabolism; pathology; pruritus; sensation | English | 2020 | 2020-08-27 | 10.1186/s13041-020-00660-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The role of the VosA-repressed dnjA gene in development and metabolism in Aspergillus species | The DnaJ family of proteins (or J-proteins) are molecular chaperones that govern protein folding, degradation, and translocation in many organisms. Although J-proteins play key roles in eukaryotic and prokaryotic biology, the role of J-proteins in Aspergillus species is currently unknown. In this study, we characterized the dnjA gene, which encodes a putative DnaJ protein, in two Aspergillus species: Aspergillus nidulans and Aspergillus flavus. Expression of the dnjA gene is inhibited by the velvet regulator VosA, which plays a pivotal role in spore survival and metabolism in Aspergillus. The deletion of dnjA decreased the number of asexual spores (conidia), produced abnormal conidiophores, and reduced sexual fruiting bodies (cleistothecia) or sclerotia. In addition, the absence of dnjA caused increased sterigmatocystin or aflatoxin production in A. nidulans and A. flavus, respectively. These results suggest that DnjA plays a conserved role in asexual and sexual development and mycotoxin production in Aspergillus species. However, DnjA also plays a species-specific role; AniDnjA but not AflDnjA, affects conidial viability, trehalose contents, and thermal tolerance of conidia. In plant virulence assay, the infection ability of the Delta AfldnjA mutant decreased in the kernels, suggesting that DnjA plays a crucial role in the pathogenicity of A. flavus. Taken together, these results demonstrate that DnjA is multifunctional in Aspergillus species; it is involved in diverse biological processes, including fungal differentiation and secondary metabolism. | Son, Ye-Eun; Cho, He-Jin; Chen, Wanping; Son, Sung-Hun; Lee, Mi-Kyung; Yu, Jae-Hyuk; Park, Hee-Soo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, 80 Daehak Ro, Daegu 41566, South Korea; Univ Gottingen, Dept Mol Microbiol & Genet, Gottingen, Germany; KRIBB, BRC, Jeongeup Si, South Korea; Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA; Konkuk Univ, Dept Syst Biotechnol, Seoul 05030, South Korea | Park, Hee-Soo/AAC-6422-2019; Yu, Jae-Hyuk/A-2343-2008 | 57200513491; 57214721558; 55715932300; 57214091244; 57221217721; 7405531243; 15751448400 | phsoo97@knu.ac.kr; | CURRENT GENETICS | CURR GENET | 0172-8083 | 1432-0983 | 66 | 3 | SCIE | GENETICS & HEREDITY | 2020 | 3.886 | 41.2 | 0.96 | 2025-06-25 | 21 | 19 | DnaJ domain; Asexual development; Aflatoxins; Aspergillus nidulans; Aspergillus flavus | J-PROTEIN FAMILY; SECONDARY METABOLISM; ASEXUAL SPORULATION; SEXUAL DEVELOPMENT; ESCHERICHIA-COLI; DNAJ; BIOGENESIS; DIVERSITY; CHAPERONE; FUNGI | Aflatoxins; Asexual development; Aspergillus flavus; Aspergillus nidulans; DnaJ domain | Aspergillus flavus; Aspergillus nidulans; Fungal Proteins; Gene Expression Regulation, Fungal; Plant Diseases; Species Specificity; Spores, Fungal; Thermotolerance; Trehalose; Triticum; aflatoxin; mycotoxin; protein DnaJ; sterigmatocystin; trehalose; fungal protein; trehalose; Article; asexual spore; Aspergillus flavus; Aspergillus nidulans; cell differentiation; conidium; controlled study; dnja gene; fruiting body; fungal development; fungal gene; fungal metabolism; fungal plant disease; fungal sclerotium; fungal viability; fungal virulence; fungus mutant; fungus spore; gene deletion; heat tolerance; nonhuman; priority journal; secondary metabolism; species; species difference; survival; toxin synthesis; Aspergillus flavus; Aspergillus nidulans; gene expression regulation; genetics; growth, development and aging; metabolism; microbiology; pathogenicity; plant disease; wheat | English | 2020 | 2020-06 | 10.1007/s00294-020-01058-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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