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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Impacts of Tocolytics on Maternal and Neonatal Glucose Levels in Women With Gestational Diabetes Mellitus Background: We investigated the impacts of tocolytic agents on maternal and neonatal blood glucose levels in women with gestational diabetes mellitus (GDM) who used tocolytics for preterm labor. Methods: This multi-center, retrospective cohort study included women with GDM who were admitted for preterm labor from twelve hospitals in South Korea. We excluded women with multiple pregnancies, anomalies, overt DM diagnosed before pregnancy or 23 weeks of gestation, and women who received multiple tocolytics. The patients were divided according to the types of tocolytics; atosiban, ritodrine, and nifedipine group. We collected baseline maternal characteristics, pregnancy outcomes, maternal glucose levels during hospitalization, and neonatal glucose levels. We compared the frequency of maternal hyperglycemia and neonatal hypoglycemia among three groups. A multivariate logistic regression analysis was performed to evaluate the contributing factors to the occurrence of maternal hyperglycemia and neonatal hypoglycemia. Results: A total of 128 women were included: 44 (34.4%), 51 (39.8%), and 33 (25.8%) women received atosiban, ritodrine, and nifedipine, respectively. Mean fasting blood glucose (FBG) (112.3, 109.6, and 89.5 mg/dL, P = 95 mg/dL) and PPG2 (>= 120 mg/dL) levels in the atosiban and ritodrine group than in nifedipine group. The atosiban and ritodrine groups are also at increased risk of neonatal hypoglycemia (< 47 mg/dL) compared to the nifedipine group with the odds ratio of 4.58 and 4.67, respectively (P < 0.05). Conclusion: There is an increased risk of maternal hyperglycemia and neonatal hypoglycemia in women with GDM using atosiban and ritodrine tocolytics for preterm labor compared to those using nifedipine. Hong, Subeen; Seol, Hyun-Joo; Lee, Joonho; Hwang, Han Sung; Sung, Ji-Hee; Kwon, Ji Young; Lee, Seung Mi; Seong, Won Joon; Choi, Soo Ran; Kim, Seung Chul; Kim, Hee-Sun; Lee, Se Jin; Choi, Sae-Kyung; Lee, Kyung A.; Ko, Hyun Sun; Park, Hyun Soo Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Sch Med, Dept Obstet & Gynecol, Seoul, South Korea; Yonsei Univ, Coll Med, Yonsei Univ Hlth Syst, Dept Obstet & Gynecol,Inst Womens Med Life Sci, Seoul 120752, South Korea; Konkuk Univ, Sch Med, Med Ctr, Div Maternal & Fetal Med,Dept Obstet & Gynecol, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea; Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Inha Univ, Coll Med, Dept Obstet & Gynecol, Incheon, South Korea; Pusan Natl Univ, Coll Med, Dept Obstet & Gynecol, Busan, South Korea; Dongguk Univ, Ilsan Hosp, Dept Obstet & Gynecol, Goyang 10326, South Korea; Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Dept Obstet & Gynecol, Chunchon, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Providence St Joseph Eureka Hosp, Family Med Residency, Eureka, CA USA Lee, Seung Hwan/ABF-7267-2021 57208189052; 15924081200; 57203145138; 17345595900; 56347330000; 35218066400; 50262091500; 26656946000; 55756824400; 57484521500; 57195511578; 57206256821; 36924484600; 57203464136; 37026301100; 57201459522 hsparkmd@gmail.com; JOURNAL OF KOREAN MEDICAL SCIENCE J KOREAN MED SCI 1011-8934 1598-6357 39 34 SCIE MEDICINE, GENERAL & INTERNAL 2024 2.3 25.2 0.84 2025-05-07 0 1 Gestational Diabetes; Ritodrine; Atosiban; Nifedipine; Maternal Hyperglycemia; Neonatal Hypoglycemia PRETERM LABOR; ATOSIBAN; RITODRINE; HYPERGLYCEMIA; MULTICENTER; PREGNANCY; TOCOLYSIS; SAFETY; BLIND Atosiban; Gestational Diabetes; Maternal Hyperglycemia; Neonatal Hypoglycemia; Nifedipine; Ritodrine Adult; Blood Glucose; Diabetes, Gestational; Female; Humans; Hyperglycemia; Hypoglycemia; Infant, Newborn; Logistic Models; Nifedipine; Obstetric Labor, Premature; Odds Ratio; Pregnancy; Pregnancy Outcome; Republic of Korea; Retrospective Studies; Ritodrine; Tocolytic Agents; Vasotocin; argiprestocin; atosiban; nifedipine; ritodrine; uterus spasmolytic agent; adult; clinical trial; drug therapy; female; gestational diabetes; glucose blood level; human; hyperglycemia; hypoglycemia; multicenter study; newborn; odds ratio; pregnancy; pregnancy outcome; premature labor; retrospective study; South Korea; statistical model English 2024 2024-09-02 10.3346/jkms.2024.39.e236 바로가기 바로가기 바로가기 바로가기
Article Incidence of Clostridioides difficile Infections in Republic of Korea: A Prospective Study With Active Surveillance vs. National Data From Health Insurance Review & Assessment Service Background: Since the emergence of hypervirulent strains of Clostridioides difficile, the incidence of C. difficile infections (CDI) has increased significantly. Methods: To assess the incidence of CDI in Korea, we conducted a prospective multicentre observational study from October 2020 to October 2021. Additionally, we calculated the incidence of CDI from mass data obtained from the Health Insurance Review and Assessment Service (HIRA) from 2008 to 2020. Results: In the prospective study with active surveillance, 30,212 patients had diarrhoea and 907 patients were diagnosed with CDI over 1,288,571 patient -days and 193,264 admissions in 18 participating hospitals during 3 months of study period; the CDI per 10,000 patientdays was 7.04 and the CDI per 1,000 admission was 4.69. The incidence of CDI was higher in general hospitals than in tertiary hospitals: 6.38 per 10,000 patient -days (range: 3.25-12.05) and 4.18 per 1,000 admissions (range: 1.92-8.59) in 11 tertiary hospitals, vs. 9.45 per 10,000 patient -days (range: 5.68-13.90) and 6.73 per 1,000 admissions (range: 3.18-15.85) in seven general hospitals. With regard to HIRA data, the incidence of CDI in all hospitals has been increasing over the 13 -year -period: from 0.3 to 1.8 per 10,000 patient -days, 0.3 to 1.6 per 1,000 admissions, and 6.9 to 56.9 per 100,000 population, respectively. Conclusion: The incidence of CDI in Korea has been gradually increasing, and its recent value is as high as that in the United State and Europe. CDI is underestimated, particularly in general hospitals in Korea. Kim, Jieun; Myung, Rangmi; Kim, Bongyoung; Kim, Jinyeong; Kim, Tark; Lee, Mi Suk; Kim, Uh Jin; Park, Dae Won; Kim, Yeon-Sook; Lee, Chang-Seop; Kim, Eu Suk; Lee, Sun Hee; Chang, Hyun-Ha; Lee, Seung Soon; Park, Se Yoon; Choi, Hee Jung; Kim, Hye In; Ha, Young Eun; Wi, Yu Mi; Choi, Sungim; Shin, So Youn; Pai, Hyunjoo Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Natl Hlth Insurance Serv, Dept Nonbenefits Management, Wonju, South Korea; Hanyang Univ, Guri Hosp, Guri, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Internal Med, Divison Infect Dis, Bucheon, South Korea; Kyung Hee Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ, Dept Infect Dis, Med Sch, Gwangju, South Korea; Korea Univ, Dept Internal Med, Div Infect Dis, Ansan Hosp, Ansan, South Korea; Chungnam Natl Univ, Sch Med, Div Infect Dis, Daejeon, South Korea; Jeonbuk Natl Univ, Med Sch & Hosp, Dept Internal Med, Jeonju, South Korea; Jeonbuk Natl Univ, Med Sch Hosp, Res Inst Clin Med, Jeonju, South Korea; Seoul Natl Univ, Coll Med, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis, Daegu, South Korea; Hallym Univ, Coll Med, Chuncheon Sacred Heart Hosp, Dept Internal Med, Chunchon, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Daegu Fatima Hosp, Dept Infect Dis, Daegu, South Korea; Bucheon Sejong Hosp, Dept Infect Dis, Bucheon, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Div Infect Dis, Chang Won, South Korea; Dongguk Univ, Ilsan Hosp, Div Infect Dis, Goyang, South Korea; Catholic Kwandong Univ, Coll Med, Int St Marys Hosp, Dept Infect Dis, Incheon, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Div Infect Dis, 222 Wangsimni Ro, Seoul 04763, South Korea Kim, Sun/GSN-4867-2022; Kim, Ju-Hyoung/N-1450-2019; LEE, SUN HEE/AAB-5714-2022; Kim, Su Hyun/JPY-2079-2023; Lee, Chang-Seop/IQU-1791-2023; Kim, Woo/AAG-1822-2019; Kim, Jong/K-3445-2013; Kim, Seog/J-5403-2012; Kim, Bongyoung/H-3409-2018; Kim, Tark/MFH-8178-2025 56528660800; 57204877946; 55622077200; 57222440773; 55501021000; 55759244100; 55606990600; 55724785200; 57208777401; 26423010200; 22938086900; 56498686800; 7407521688; 56386309200; 55259986400; 57217262202; 57208153832; 56642344700; 23013143100; 57204670336; 56390632400; 57225132406 paihj@hanyang.ac.kr; JOURNAL OF KOREAN MEDICAL SCIENCE J KOREAN MED SCI 1011-8934 1598-6357 39 12 SCIE MEDICINE, GENERAL & INTERNAL 2024 2.3 25.2 5.64 2025-04-16 8 8 Clostridioides difficile Infection; Incidence; Active Surveillance; Big Data CLINICAL-FEATURES; EPIDEMIOLOGY; HOSPITALS Active Surveillance; Big Data; Clostridioides difficile Infection; Incidence Clostridioides difficile; Clostridium Infections; Cross Infection; Humans; Incidence; Insurance, Health; Prospective Studies; Republic of Korea; Tertiary Care Centers; Watchful Waiting; clinical trial; Clostridioides difficile; Clostridium infection; cross infection; health insurance; human; incidence; multicenter study; prospective study; South Korea; tertiary care center; watchful waiting English 2024 2024-04-01 10.3346/jkms.2024.39.e118 바로가기 바로가기 바로가기 바로가기
Article Influenza and the risk of active tuberculosis occurrence among individuals with latent tuberculosis infection: A national cohort study in South Korea (2015-2020) Background: Influenza's potential impact on active tuberculosis (TB) development has been debated, with limited clinical evidence. To address this, we explored the association between influenza episodes and TB incidence in a national cohort of individuals with latent TB infection (LTBI). Methods: We examined adults (>= 20 years) diagnosed with LTBI between 2015 and 2020, using the Health Insurance Review and Assessment Service's national database in South Korea. We collected demographic data, comorbidities, and influenza episodes within 6 months before and after the initial LTBI diagnosis (prior vs. subsequent episode). We stratified the analysis into groups with and without TB preventive therapy (TPT). Results: Among 220,483 LTBI subjects, 49% received TPT, while 51% did not. The average age was 48.4 years, with 52% having comorbidities. A prior and subsequent influenza episode was identified in 3221 and 4580 individuals, respectively. Of these, 1159 (0.53%) developed incident TB over an average follow-up of 1.86 years. The incidence rates of TB were comparable between individuals with and without prior and/or subsequent influenza episodes in the TPT group, but 1.4 times higher in the non-TPT group for those with such episodes. Cox proportional -hazards regression analysis indicated that influenza was not a risk factor for incident TB in the TPT group. However, a subsequent influenza episode significantly increased TB risk in the non-TPT group (hazard ratio: 1.648 [95% CI, 1.053-2.580]). Conclusions: In individuals with LTBI not receiving TPT, experiencing an influenza episode may elevate the risk of developing active TB. Lee, Jaehee; Seo, Hyewon; Kim, Dohyang; Hwang, Jinseub; Kwon, Jin-Won Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Univ, Dept Stat, Gyeongbuk, South Korea; Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, 80 Daehak Ro, Daegu 41566, South Korea Lee, Jaehee/S-1697-2018; Lee, Jun Young/CAI-2335-2022 13805476000; 55612130200; 57218821860; 57189231296; 16202951700 jaelee@knu.ac.kr;seohw@knu.ac.kr;gj1705@naver.com;hjs04090409@gmail.com;jwkwon@knu.ac.kr; JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION J MICROBIOL IMMUNOL 1684-1182 1995-9133 57 3 SCIE IMMUNOLOGY;INFECTIOUS DISEASES;MICROBIOLOGY 2024 3.7 25.2 1.38 2025-05-07 3 2 Latent tuberculosis infection; Incident tuberculosis; Influenza; Risk Incident tuberculosis; Influenza; Latent tuberculosis infection; Risk Adult; Aged; Cohort Studies; Comorbidity; Female; Humans; Incidence; Influenza, Human; Latent Tuberculosis; Male; Middle Aged; Proportional Hazards Models; Republic of Korea; Risk Factors; Tuberculosis; Young Adult; isoniazid; rifampicin; adult; aged; Article; cohort analysis; comorbidity; controlled study; cumulative incidence; female; follow up; human; incidence; infection risk; influenza; latent tuberculosis; major clinical study; male; risk factor; South Korea; tuberculosis; very elderly; complication; epidemiology; middle aged; proportional hazards model; tuberculosis; young adult English 2024 2024-06 10.1016/j.jmii.2024.04.003 바로가기 바로가기 바로가기 바로가기
Article Modified Albumin-Bilirubin Grade After Curative Treatment: Predicting the Risk of Late Intrahepatic Recurrence of Hepatocellular Carcinoma Background: We aimed to identify the prognostic factors for late intrahepatic recurrence (IHR), defined as recurrence more than two years after curative treatment of newly diagnosed hepatocellular carcinoma (HCC). Methods: This retrospective cohort study included patients with newly diagnosed, previously untreated, very early, or early HCC treated with initial curative treatment and followed up without recurrence for more than two years, excluding early IHR defined as recurrence within two years in single center. Late IHR-free survival (IHRFS) was defined as the time interval from initial curative treatment to the first IHR or death without IHR, whichever occurred first. Results: Among all the enrolled 2,304 patients, 1,427 (61.9%) underwent curative intent hepatectomy and the remaining 877 (38.1%) underwent local ablative therapy (LAT). During the follow-up after curative treatment (median, 82.6 months; range, 24.1 to 195.7), late IHR was detected in 816 (35.4%) patients. In the multivariable analysis, age, male sex, cirrhotic liver at diagnosis, type of initial treatment, and modified albumin-bilirubin (mALBI) grade were significant prognostic baseline factors. Furthermore, mALBI grade at three (2a vs. 1, P = 0.02, hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.04-1.70; 2b/3 vs. 1, P = 0.03; HR, 1.42; 95% CI, 1.03-1.94) and six months (2b/3 vs. 1; P = 0.006; HR, 1.61; 95% CI, 1.13-2.30) after initial curative treatment was also a significant prognostic factor for late IHR. Conclusion: After curative treatment for newly diagnosed early HCC, the mALBI grade at three and six months after initial curative treatment, as well as at baseline, was one of the most crucial prognostic factors for late IHR. Goh, Myung Ji; Park, Hee Chul; Kim, Nalee; Bae, Bong Kyung; Choi, Moon Seok; Rhu, Jinsoo; Lee, Min Woo; Jeong, Woo Kyoung; Kim, Minji; Kim, Kyunga; Yu, Jeong Il Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiat Oncol, 81 Irwon Ro, Seoul 06351, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Radiat Oncol, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Surg, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul, South Korea; Samsung Med Ctr, Res Inst Future Med, Biomed Stat Ctr, Seoul, South Korea ; Kim, Nalee/KGK-4760-2024; Kim, Kyunga/LCL-2839-2024; Yu, Jeong Il/MTC-0984-2025; Jeong, Woo Kyoung/ABE-7025-2021; Lee, Jaewon/AFM-0002-2022 57215026475; 7601567098; 56714463100; 57191481610; 55661123900; 54970403400; 56570691900; 14012468500; 56984405900; 57467763700; 35212472500 jeongil.yu@samsung.com; JOURNAL OF KOREAN MEDICAL SCIENCE J KOREAN MED SCI 1011-8934 1598-6357 39 37 SCIE MEDICINE, GENERAL & INTERNAL 2024 2.3 25.2 0 2025-05-07 0 0 Hepatocellular Carcinoma; Curative Treatment; Recurrence; Liver Function; Albumin-Bilirubin Grade; Prognosis RESECTION; TRIAL Albumin-Bilirubin Grade; Curative Treatment; Hepatocellular Carcinoma; Liver Function; Prognosis; Recurrence Adult; Aged; Bilirubin; Carcinoma, Hepatocellular; Disease-Free Survival; Female; Hepatectomy; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Factors; Serum Albumin; bilirubin; serum albumin; adult; aged; blood; diagnosis; disease free survival; female; hepatectomy; human; liver cell carcinoma; liver tumor; male; metabolism; middle aged; mortality; pathology; prognosis; proportional hazards model; retrospective study; risk factor; surgery; tumor recurrence English 2024 2024-09-30 10.3346/jkms.2024.39.e251 바로가기 바로가기 바로가기 바로가기
Article Pediatric Extracorporeal Membrane Oxygenation in Korea: A Multicenter Retrospective Study on Utilization and Outcomes Spanning Over a Decade Background: Over the last decade, extracorporeal membrane oxygenation (ECMO) use in critically ill children has increased and is associated with favorable outcomes. Our study aims to evaluate the current status of pediatric ECMO in Korea, with a specific focus on its volume and changes in survival rates based on diagnostic indications. Methods: This multicenter study retrospectively analyzed the indications and outcomes of pediatric ECMO over 10 years in patients at 14 hospitals in Korea from January 2012 to December 2021. Four diagnostic categories (neonatal respiratory, pediatric respiratory, postcardiotomy, and cardiac-medical) and trends were compared between periods 1 (2012-2016) and 2 (2017-2021). Results: Overall, 1065 ECMO runs were performed on 1032 patients, with the annual number of cases remaining unchanged over the 10 years. ECMO was most frequently used for post-cardiotomy (42.4%), cardiac-medical (31.8%), pediatric respiratory (17.5%), and neonatal respiratory (8.2%) cases. A 3.7% increase and 6.1% decrease in pediatric respiratory and post-cardiotomy cases, respectively, were noted between periods 1 and 2. Among the four groups, the cardiac-medical group had the highest survival rate (51.2%), followed by the pediatric respiratory (46.4%), post-cardiotomy (36.5%), and neonatal respiratory (29.4%) groups. A consistent improvement was noted in patient survival over the 10 years, with a significant increase between the two periods from 38.2% to 47.1% (P = 0.004). Improvement in survival was evident in post-cardiotomy cases (30-45%, P = 0.002). Significant associations with mortality were observed in neonates, patients requiring dialysis, and those treated with extracorporeal cardiopulmonary resuscitation (P < 0.001). In pediatric respiratory ECMO, immunocompromised patients also showed a significant correlation with mortality (P < 0.001). Conclusion: Pediatric ECMO demonstrated a steady increase in overall survival in Korea; however, further efforts are needed since the outcomes remain suboptimal compared with global outcomes. Choi, Yu Hyeon; Jhang, Won Kyoung; Park, Seong Jong; Choi, Hee Joung; Oh, Min-Su; Kwon, Jung Eun; Kim, Beom Joon; Shin, Ju Ae; Lee, In Kyung; Park, June Dong; Lee, Bongjin; Chung, Hyun; Na, Jae Yoon; Choi, Ah Young; Cho, Joongbum; Choi, Jaeyoung; Cho, Hwa Jin; Kim, Ah Young; Shin, Yu Rim; Byun, Joung-Hee; Kim, Younga Seoul Med Ctr, Dept Pediat, Seoul, South Korea; Univ Ulsan, Dept Pediat, Asan Med Ctr Childrens Hosp, Coll Med, Seoul, South Korea; Keimyung Univ, Dongsan Hosp, Dept Pediat, Sch Med, Daegu, South Korea; Jeju Natl Univ, Jeju Natl Univ Hosp, Dept Pediat, Coll Med, Jeju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Catholic Univ Korea, Eunpyeong St Marys Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Pediat, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea; Sejong Gen Hosp, Dept Pediat, Bucheon, South Korea; Hanyang Univ, Coll Med, Dept Pediat, Seoul, South Korea; Chungnam Natl Univ Hosp, Dept Pediat, Daejeon, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Crit Care Med, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, Seoul, South Korea; Chonnam Natl Univ, Childrens Hosp, Dept Pediat, Gwangju, South Korea; Med Sch, Gwangju, South Korea; Yonsei Univ, Severance Hosp, Dept Pediat, Coll Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Thorac & Cardiovasc Surg, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Pediat, Sch Med, Yangsan, South Korea; Pusan Natl Univ, Yangsan Hosp, Sch Med, 20 Geumo Ro, Yangsan 50612, South Korea ; Lee, Bong-Jin/AAQ-1609-2020; Kim, Yong-Hoon/AAC-5500-2022; Choi, Youn/AAS-3301-2021; Lee, JongGu/B-7384-2013; Cho, Hwa Jin/AFA-1420-2022; Kim, Youngmin/C-7926-2019; Park, June/J-5496-2012 56583002600; 23481560600; 35211375100; 25937150300; 57189639737; 57194002366; 57216253267; 57194702863; 58846061700; 8621069800; 57209267054; 57195928308; 57221383861; 57209531173; 50360978300; 57202550087; 40561069100; 57190798342; 57226204951; 57196050893; 57196050642 youngflo@daum.net; JOURNAL OF KOREAN MEDICAL SCIENCE J KOREAN MED SCI 1011-8934 1598-6357 39 3 SCIE MEDICINE, GENERAL & INTERNAL 2024 2.3 25.2 0.94 2025-04-16 1 1 Extracorporeal Membrane Oxygenation; Pediatric; Neonates; Children; Survival Rate CONGENITAL HEART-DISEASE; BIRTH-WEIGHT INFANTS; LIFE-SUPPORT; CARE; ASSOCIATION; FOUNDATION; SURVIVAL; UPDATE; VOLUME Children; Extracorporeal Membrane Oxygenation; Neonates; Pediatric; Survival Rate Cardiopulmonary Resuscitation; Child; Extracorporeal Membrane Oxygenation; Heart; Humans; Infant, Newborn; Republic of Korea; Retrospective Studies; child; clinical trial; epidemiology; extracorporeal oxygenation; heart; human; multicenter study; newborn; resuscitation; retrospective study; South Korea English 2024 2024-01-22 10.3346/jkms.2024.39.e33 바로가기 바로가기 바로가기 바로가기
Article Prevalence and Associated Factors of Depression and Anxiety Among Healthcare Workers During the Coronavirus Disease 2019 Pandemic: A Nationwide Study in Korea Background: A healthcare system's collapse due to a pandemic, such as the coronavirus disease 2019 (COVID-19), can expose healthcare workers (HCWs) to various mental health problems. This study aimed to investigate the impact of the COVID-19 pandemic on the depression and anxiety of HCWs. Methods: A nationwide questionnaire -based survey was conducted on HCWs who worked in healthcare facilities and public health centers in Korea in December 2020. Patient Health Questionnaire -9 (PHQ-9) and Generalized Anxiety Disorder -7 (GAD -7) were used to measure depression and anxiety. To investigate factors associated with depression and anxiety, stepwise multiple logistic regression analysis was performed. Results: A total of 1,425 participating HCWs were included. The mean depression score (PHQ-9) of HCWs before and after COVID-19 increased from 2.37 to 5.39, and the mean anxiety score (GAD -7) increased from 1.41 to 3.41. The proportion of HCWs with moderate to severe depression (PHQ-9 >= 10) increased from 3.8% before COVID-19 to 19.5% after COVID-19, whereas that of HCWs with moderate to severe anxiety (GAD -7 >= 10) increased from 2.0% to 10.1%. In our study, insomnia, chronic fatigue symptoms and physical symptoms after COVID-19, anxiety score (GAD -7) after COVID-19, living alone, and exhaustion were positively correlated with depression. Furthermore, post -traumatic stress symptoms, stress score (Global Assessment of Recent Stress), depression score (PHQ-9) after COVID-19, and exhaustion were positively correlated with anxiety. Conclusion: In Korea, during the COVID-19 pandemic, HCWs commonly suffered from mental health problems, including depression and anxiety. Regularly checking the physical and mental health problems of HCWs during the COVID-19 pandemic is crucial, and social support and strategy are needed to reduce the heavy workload and psychological distress of HCWs. Lee, Shinwon; Hwang, Soyoon; Kwon, Ki Tae; Nam, Eunkyung; Chung, Un Sun; Kim, Shin-Woo; Chang, Hyun-Ha; Kim, Yoonjung; Bae, Sohyun; Shin, Ji-Yeon; Bae, Sang-geun; Ryoo, Hyun Wook; Jeong, Juhwan; Oh, Namhee; Lee, So Hee; Kim, Yeonjae; Kang, Chang Kyung; Park, Hye Yoon; Park, Jiho; Park, Se Yoon; Kim, Bongyoung; Cheong, Hae Suk; Son, Ji Woong; Lim, Su Jin; Yun, Seongcheol; Oh, Won Sup; Park, Kyung-Hwa; Lee, Ju-Yeon; Heo, Sang Taek; Lee, Ji-yeon Pusan Natl Univ, Sch Med, Dept Internal Med, Pusan Natl Univ, Busan, South Korea; Pusan Natl Univ Hosp, Med Res Inst, Busan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis,Chilgok Hosp, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Childrens Hosp, Sch Med, Dept Psychiat, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Div Infect Dis, Daegu, South Korea; Daegu Med Ctr, Hosp Infect Control Team, Daegu, South Korea; Natl Med Ctr, Dept Psychiat, Seoul, South Korea; Natl Med Ctr, Dept Internal Med, Div Infect Dis, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Psychiat, Seoul, South Korea; Konkuk Univ, Sch Med, Med Ctr, Dept Internal Med, Seoul, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Div Infect Dis,Sch Med, Seoul, South Korea; Konyang Univ Hosp, Dept Internal Med, Daejeon, South Korea; Masan Med Ctr, Dept Internal Med, Div Resp Dis, Chang Won, South Korea; Andong Med Ctr, Dept Internal Med, Andong, South Korea; Kangwon Natl Univ, Dept Internal Med, Div Infect Dis, Sch Med, Chunchon, South Korea; Chonnam Natl Univ, Med Sch, Dept Infect Dis, Gwangju, South Korea; Chonnam Natl Univ, Med Sch, Dept Psychiat, Gwangju, South Korea; Jeju Natl Univ, Dept Internal Med, Div Infect Dis, Coll Med, Jeju, South Korea; Hankuk Univ Foreign Studies, Dept Counseling Psychol, Seoul, South Korea ; Lee, So Hee/B-5940-2016; Lee, Jung-Seok/L-6826-2019; Kim, Hanjin/KYP-2633-2024; Kim, Wonhee/AAA-1074-2021; Hwang, Soyoon/HHM-5762-2022; Kim, Jung/S-5543-2017 24479446100; 57203160675; 9733850500; 58121908200; 24477437300; 57189703358; 7407521688; 57203160508; 57219699506; 55567961600; 55278023500; 55350557500; 58981143700; 57195674103; 56442744300; 56066688300; 55808491400; 57189505933; 57452625000; 55259986400; 55622077200; 57233155100; 57217473793; 57222279275; 57218948065; 24778642500; 57219637574; 57203144588; 9737963500; 57201650869 ktkwon@knu.ac.kr;unsunchung@gmail.com; JOURNAL OF KOREAN MEDICAL SCIENCE J KOREAN MED SCI 1011-8934 1598-6357 39 13 SCIE MEDICINE, GENERAL & INTERNAL 2024 2.3 25.2 0.94 2025-04-16 1 3 Depression; Anxiety; COVID-19; Pandemic; Healthcare Worker ACUTE RESPIRATORY SYNDROME; GENERAL-POPULATION; SUICIDAL IDEATION; INSOMNIA; SEVERITY; COVID-19; VALIDATION; VERSION; SYMPTOMS; FATIGUE Anxiety; COVID-19; Depression; Healthcare Worker; Pandemic Anxiety; Anxiety Disorders; COVID-19; Depression; Health Personnel; Humans; Pandemics; Prevalence; Republic of Korea; anxiety; anxiety disorder; coronavirus disease 2019; depression; health care personnel; human; pandemic; prevalence; South Korea English 2024 2024-04-08 10.3346/jkms.2024.39.e120 바로가기 바로가기 바로가기 바로가기
Article Real-World Eligibility and Cost-Effectiveness Analysis of Empagliflozin for Heart Failure in Korea Background: The US Food and Drug Administration (FDA) and European Medicines Agency (EMA) approved empagliflozin for reducing cardiovascular mortality and heart failure (HF) hospitalization in patients with both HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). However, limited data are available on the generalizability of empagliflozin to clinical practice. Therefore, we evaluated real-world eligibility and potential cost-effectiveness based on a nationwide prospective HF registry.Methods: A total of 3,108 HFrEF and 2,070 HFpEF patients from the Korean Acute Heart Failure (KorAHF) registry were analyzed. Eligibility was estimated by inclusion and exclusion criteria of EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced) and EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction (EMPEROR-Preserved) trials and by FDA & EMA label criteria. The cost-utility analysis was done using a Markov model to project the lifetime medical cost and quality-adjusted life year (QALY).Results: Among the KorAHF patients, 91.4% met FDA & EMA label criteria, while 44.7% met the clinical trial criteria. The incremental cost-effectiveness ratio of empagliflozin was calculated at US$6,764 per QALY in the overall population, which is far below a threshold of US$18,182 per QALY. The cost-effectiveness benefit was more evident in patients with HFrEF (US$5,012 per QALY) than HFpEF (US$8,971 per QALY).Conclusion: There is a large discrepancy in real-world eligibility for empagliflozin between FDA & EMA labels and clinical trial criteria. Empagliflozin is cost-effective in HF patients regardless of ejection fraction in South Korea health care setting. The efficacy and safety of empagliflozin in real-world HF patients should be further investigated for a broader range of clinical applications. Kim, Eui-Soon; Park, Sun-Kyeong; Youn, Jong-Chan; Lee, Hye Sun; Lee, Hae-Young; Cho, Hyun-Jai; Choi, Jin-Oh; Jeon, Eun-Seok; Lee, Sang Eun; Kim, Min-Seok; Kim, Jae-Joong; Hwang, Kyung-Kuk; Cho, Myeong-Chan; Chae, Shung Chull; Kang, Seok-Min; Park, Jin Joo; Choi, Dong-Ju; Yoo, Byung-Su; Cho, Jae Yeong; Kim, Kye Hun; Oh, Byung-Hee; Greenberg, Barry; Baek, Sang Hong Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea; Catholic Univ Korea, Coll Pharm, Bucheon, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Catholic Res Inst Intractable Cardiovasc Dis, Coll Med,Div Cardiol,Dept Internal Med, Seoul, South Korea; Yonsei Univ, Coll Med, Biostat Collaborat Unit, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul, South Korea; Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; Kyungpook Natl Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnam, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea; Chonnam Natl Univ, Med Sch, Dept Cardiovasc Med, Gwangju, South Korea; Incheon Sejong Hosp, Dept Cardiovasc Med, Incheon, South Korea; UC San Diego Hlth Syst, Dept Radiol, La Jolla, CA USA; Catholic Univ Korea, Seoul St Marys Hosp, Catholic Res Inst Intractable Cardiovasc Dis, Coll Med,Div Cardiol,Dept Internal Med, 222 Banpo Daero, Seoul 06591, South Korea Kim, Soo-Yeon/ADR-9663-2022; Jeong, Gi/AAB-2830-2021; Lee, Hye/J-2154-2015; Youn, Jong-Chan/AAS-1405-2020; LEE, JI/L-6920-2013; Cho, Jae Yeong/GVT-2986-2022; Lee, Hye Sun/J-2154-2015; Oh, Byung-Hee/G-9875-2011; Choi, Dong-Ju/J-5686-2012; choi, jo/O-5940-2014 57220956934; 56010737100; 14070921900; 57208650357; 56151235500; 35285421400; 15848011800; 7004279641; 57207065107; 57212315719; 57225030259; 58842870300; 58092080500; 7101962036; 7405685375; 35799900000; 35274349200; 7102851884; 23024350000; 56150430800; 57216293873; 7201629440; 7201371594 jong.chan.youn@gmail.com; JOURNAL OF KOREAN MEDICAL SCIENCE J KOREAN MED SCI 1011-8934 1598-6357 39 1 SCIE MEDICINE, GENERAL & INTERNAL 2024 2.3 25.2 0.94 2025-04-16 4 1 SGLT2 Inhibitors; Empagliflozin; Heart Failure; Drug Therapy; Cost-Effectiveness Analysis CARDIOVASCULAR OUTCOMES; BLOOD-PRESSURE; HYPERTENSION; ASSOCIATION; MANAGEMENT; MORTALITY; TRIALS Cost-Effectiveness Analysis; Drug Therapy; Empagliflozin; Heart Failure; SGLT2 Inhibitors Cost-Effectiveness Analysis; Heart Failure; Humans; Prospective Studies; Republic of Korea; Stroke Volume; United States; empagliflozin; cost effectiveness analysis; heart failure; heart stroke volume; human; prospective study; South Korea; United States English 2024 2024-01-08 10.3346/jkms.2024.39.e8 바로가기 바로가기 바로가기 바로가기
Article Sites of Metastasis and Survival in Metastatic Renal Cell Carcinoma: Results From the Korean Renal Cancer Study Group Database Background: In patients with metastatic renal cell carcinoma (mRCC), sites of metastatic involvement have been reported to be associated with a difference in survival. However, frequency and survival according to different sites of metastases in Korean patients with mRCC remain unclear. Therefore, this study aimed to assess the frequency of metastatic site involvement and the association between sites of metastatic involvement and survival Korean patients with mRCC. Methods: This retrospective study used the multicenter cohort of the Korean Renal Cancer Study Group mRCC database to identify patients who started targeted therapy between December 2005 and March 2018. Data on the frequency of metastatic organ involvement at the time of mRCC diagnosis and oncologic outcomes according to different sites of metastasis were analyzed. Results: A total of 1,761 patients were eligible for analysis. Of the 1,761 patients, 1,564 (88.8%) had clear cell RCC, and 1,040 (59.1%) had synchronous metastasis. The median number of metastasis sites was 2 (interquartile range [IQR], 1-6). The median age at the initiation of systemic therapy was 60 years (IQR, 29-88), 1,380 (78.4%) were men, and 1,341 (76.1%) underwent nephrectomy. Based on the International Metastatic Renal Cell Carcinoma Database Consortium model, patients were stratified into favorable-, intermediate-, and poor-risk groups with 359 (20.4%), 1,092 (62.0%), and 310 (17.6%) patients, respectively. The lung (70.9%), lymph nodes (37.9%), bone (30.7%), liver (12.7%), adrenal gland (9.8%), and brain (8.2%) were the most common sites of metastasis, followed by the pancreas, pleura, peritoneum, spleen, thyroid, and bowel. Among the most common sites of metastasis (> 5%), the median cancer-specific survival (CSS) ranged from 13.9 (liver) to 29.1 months (lung). An association was observed between liver, bone, and pleural metastases and the shortest median CSS (< 19 months). Conclusion: In Korean patients with mRCC, metastases to the lung, lymph nodes, bone, liver, adrenal gland, and brain were more frequent than those to other organs. Metastases to the liver, bone, and pleura were associated with poor CSS. The findings of this study may be valuable for patient counseling and guiding future study designs. Lee, Chan Ho; Kang, Minyong; Kwak, Cheol; Ko, Young Hwii; Kim, Jung Kwon; Park, Jae Young; Bang, Seokhwan; Il Seo, Seong; Suh, Jungyo; Song, Wan; Song, Cheryn; Lee, Hyung Ho; Chung, Jinsoo; Jeong, Chang Wook; Jo, Jung Ki; Choi, Seock Hwan; Choi, Joongwon; Choi, Changil; Choo, Seol Ho; Han, Jang Hee; Hong, Sung-Hoo; Hwang, Eu Chang Inje Univ, Busan Paik Hosp, Coll Med, Dept Urol, Busan, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Urol, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Urol, Seoul, South Korea; Yeungnam Univ, Coll Med, Dept Urol, Daegu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Urol, Seoul, South Korea; Korea Univ, Ansan Hosp, Dept Urol, Coll Med, Ansan, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Urol, Seoul, South Korea; Natl Canc Ctr, Ctr Urol Canc, Dept Urol, Goyang, South Korea; Hanyang Univ, Coll Med, Dept Urol, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Urol, Daegu, South Korea; Chung Ang Univ, Gwangmyeong Hosp, Dept Urol, Coll Med, Gwangmyeong, South Korea; Hallym Univ, Sch Med, Dongtan Sacred Heart Hosp, Dept Pathol, Hwaseong, South Korea; Ajou Univ, Ajou Univ Hosp, Sch Med, Dept Gastroenterol, Suwon, South Korea; Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Urol, Hwasun, South Korea ; Kwak, Cheol/J-2731-2012; Park, Jae young/AFQ-0813-2022; Park, Jae Young/AFQ-0813-2022; Hwang, Eu/K-3680-2019; Ko, Young Hwii/GRX-0718-2022; Choi, Joongwon/ABG-8559-2021 55855972900; 23489077600; 7005639032; 25723368800; 58757961300; 55717166600; 57201129776; 7202469835; 57193006727; 56079751200; 10040623600; 54383550000; 16678454900; 8879131000; 37060991000; 9742645500; 57208742789; 57203975172; 56506584700; 57412154000; 37030299600; 8441681300 urohwang@gmail.com; JOURNAL OF KOREAN MEDICAL SCIENCE J KOREAN MED SCI 1011-8934 1598-6357 39 45 SCIE MEDICINE, GENERAL & INTERNAL 2024 2.3 25.2 0.84 2025-05-07 2 2 Carcinoma, Renal Cell; Neoplasm Metastasis; Molecular Targeted Therapy; Survival; Prognosis PROGNOSTIC-FACTORS; CABOZANTINIB; SUNITINIB; THERAPY; TUMORS Carcinoma; Molecular Targeted Therapy; Neoplasm Metastasis; Prognosis; Renal Cell; Survival Adult; Aged; Aged, 80 and over; Bone Neoplasms; Carcinoma, Renal Cell; Databases, Factual; Female; Humans; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Nephrectomy; Republic of Korea; Retrospective Studies; adult; aged; bone tumor; epidemiology; factual database; female; human; kidney tumor; liver tumor; lung tumor; lymph node metastasis; male; middle aged; mortality; nephrectomy; pathology; renal cell carcinoma; retrospective study; South Korea; very elderly English 2024 2024-11-25 10.3346/jkms.2024.39.e293 바로가기 바로가기 바로가기 바로가기
Article Spirometric Interpretation and Clinical Relevance According to Different Reference Equations Background: Global Lung Function Initiative (GLI)-2012 reference equation is currently suggested for interpretation of spirometry results and a new local reference equation has been developed in South Korea. However, lung function profiles according to the different reference equations and their clinical relevance have not been identified in chronic obstructive pulmonary disease (COPD) patients. Methods: Our cross-sectional study evaluated Choi's, Korean National Health and National Examination Survey (KNHANES)-VI, and GLI-2012 reference equations. We estimated the percentages of predictive forced expiratory volume in one second (FEV1) and airflow limitation severity according to reference equations and analyzed their associations with patient reported outcomes (PROs): COPD assessment test (CAT) score, St. George's Respiratory Questionnaire for COPD patients (SGRQ-C) score, and six minute walk distance (6MWD). Results: In the eligible 2,180 COPD patients, lower predicted values of FEV1 and forced vital capacity (FVC) were found in GLI-2012 compared to Choi's and KNHANES-VI equations. GLI-2012 equation resulted in a lower proportion of patients being classified as FEV1 < 80% or FVC < 80% compared to the other equations. However, the Z -scores of FEV1 and FVC were similar between the KNHANES-VI and GLI-2012 equations. Three reference equations exhibited significant associations between FEV1 (%) and patient -reported outcomes (CAT score, SGRQ-C score, and 6MWD). Conclusion: GLI-2012 reference equation may not accurately reflect FEV1 (%) in the Korean population, but the Z -score using GLI-2012 equation can be a viable option for assessing FEV1 and airflow limitation in COPD patients. Similar to the other two equations, the GLI-2012 equation demonstrated significant associations with PROs. Lee, Hyun Woo; Lee, Jung-Kyu; Hwang, Yong-Il; Seo, Hyewon; Ahn, June Hong; Kim, Sung-Ryeol; Kim, Hyun Jung; Jung, Ki-Suck; Yoo, Kwang Ha; Kim, Deog Kyeom Seoul Natl Univ, Seoul Metropolitan Govt Seoul Natl Univ Boramae Me, Dept Internal Med, Div Resp & Crit Care,Coll Med, Seoul, South Korea; Hallym Univ, Dept Internal Med, Div Pulm Allergy & Crit Care Med, Sacred Heart Hosp, Anyang, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yeungnam Univ, Med Ctr, Coll Med, Dept Internal Med, Daegu, South Korea; Yonsei Univ, Yongin Severance Hosp, Dept Internal Med, Coll Med, Yongin, South Korea; Keimyung Univ, Dept Internal Med, Div Pulm & Crit Care Med, Dongsan Hosp, Daegu, South Korea; Hallym Univ, Coll Med, Div Pulm Allergy & Crit Care Med, Sacred Heart Hosp, Anyang, South Korea; Konkuk Univ, Dept Internal Med, Sch Med, Seoul, South Korea; Seoul Natl Univ, Seoul Metropolitan Govt Seoul Natl Univ Boramae Me, Dept Internal Med, Div Resp & Crit Care,Coll Med, 20 Boramae Ro 5 Gil, Seoul 07061, South Korea ; Lee, Hyun Woo/AAH-8473-2020; Hyun-Jung, Kim/E-8074-2011; Jung, Ki-Suck/AAN-2473-2021; HWANG, YONG/AAU-7121-2021; Kim, Sung-Ryeol/L-9266-2019; Ahn, June/AAB-3093-2019 57205720858; 55937212800; 34570249800; 55612130200; 56645445800; 56396079900; 57196215317; 7402479869; 57693301700; 14060371000 kimdkmd@gmail.com; JOURNAL OF KOREAN MEDICAL SCIENCE J KOREAN MED SCI 1011-8934 1598-6357 39 4 SCIE MEDICINE, GENERAL & INTERNAL 2024 2.3 25.2 5.64 2025-04-16 8 8 Spirometry; Pulmonary Disease, Chronic Obstructive; Reference Values; Forced Expiratory Volume; Patient Reported Outcome Measures OBSTRUCTIVE PULMONARY-DISEASE; REFERENCE VALUES; COPD; POPULATION; OUTCOMES; DECLINE; KOREA; FEV1; AGE Chronic Obstructive; Forced Expiratory Volume; Patient Reported Outcome Measures; Pulmonary Disease; Reference Values; Spirometry Clinical Relevance; Cross-Sectional Studies; Forced Expiratory Volume; Humans; Lung; Pulmonary Disease, Chronic Obstructive; Reference Values; Spirometry; Vital Capacity; chronic obstructive lung disease; clinical significance; cross-sectional study; forced expiratory volume; human; lung; reference value; spirometry; vital capacity English 2024 2024-01-29 10.3346/jkms.2024.39.e20 바로가기 바로가기 바로가기 바로가기
Article Suicide Rates and Subgroups With Elevated Suicide Risk Among Patients With Psychiatric Disorders: A Nationwide Cohort Study in Korea Background: Despite the distinctly high risk of suicide among patients with psychiatric disorders, little is known regarding the nationwide rates and risk factors for suicide among individual subgroups of patients with psychiatric disorders. This study aimed to assess differences in suicide rates and identify risk factors for suicide across multiple psychiatric diseases using data from a nationally representative cohort in Korea. Methods: Six groups of incident patients with psychiatric disorders, namely those with drug use disorder (DUD), alcohol use disorder (AUD), schizophrenia (SCZ), bipolar disorder (BD), depressive disorder (DD), or other affective disorders (OADs), were extracted from the National Health Information Database and followed up. Suicide rates and risk factors were then determined for each disease group. Results: Patients with psychiatric disorders had higher suicide rates than did the general population, with standardized mortality ratios (SMRs) ranging from 2.5 to 16.6. In particular, patients with DUD showed markedly higher suicide rate (584.0 per 100,000 person-years [PYs]; SMR, 16.6) than did patients with affective disorders, including DD (119.8 per 100,000 PYs; SMR, 3.1). AUD, DUD, SCZ, and BD showed lower male/female suicide rate ratios (1.1-1.4) than did depressive and OADs (2.2-2.4). Old age increased the risk for suicide among those with DUD and OADs, while medical aid recipients exhibited the lowest suicide risk among those with the AUD and SCZ. Male sex and the presence of multiple psychiatric comorbidities were consistently identified as suicide risk factors across mental illness subgroups. Conclusion: The current study observed substantial variations in suicide rates and risk factors across psychiatric disorders and patient characteristics, which have significant implications for suicide prevention strategies. Kang, Jiwon; Lim, Jiseun; Lee, Junhee; Shin, Ji-Yeon Eulji Univ, Coll Med, Dept Prevent Med, 77 Gyerong Ro 771 Beon Gil, Daejeon 34824, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Psychiat, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu, South Korea 57789010700; 55630938100; 57196137310; 55567961600 limjiseun@gmail.com; JOURNAL OF KOREAN MEDICAL SCIENCE J KOREAN MED SCI 1011-8934 1598-6357 39 39 SCIE MEDICINE, GENERAL & INTERNAL 2024 2.3 25.2 0.84 2025-05-07 1 1 Suicide; Risk Factors; Mental Disorders; Cohort Studies; Suicide Prevention RETROSPECTIVE COHORT; PSYCHOTIC DISORDERS; COMPLETED SUICIDE; MENTAL-DISORDERS; PREVALENCE; SCHIZOPHRENIA; CONTACTS; DEATH Cohort Studies; Mental Disorders; Risk Factors; Suicide; Suicide Prevention Adolescent; Adult; Aged; Alcoholism; Bipolar Disorder; Cohort Studies; Databases, Factual; Depressive Disorder; Female; Humans; Male; Mental Disorders; Middle Aged; Republic of Korea; Risk Factors; Schizophrenia; Substance-Related Disorders; Suicide; Young Adult; adolescent; adult; aged; alcoholism; bipolar disorder; cohort analysis; complication; depression; drug dependence; epidemiology; factual database; female; human; male; mental disease; middle aged; risk factor; schizophrenia; South Korea; suicide; young adult English 2024 2024-10-14 10.3346/jkms.2024.39.e264 바로가기 바로가기 바로가기 바로가기
Article The Impact of an Antimicrobial Stewardship Program on Days of Therapy in the Pediatric Center: An Interrupted Time-Series Analysis of a 19-Year Study Background: We aimed to analyze the effects of an antimicrobial stewardship program (ASP) on the proportion of antimicrobial -resistant pathogens in bacteremia, antimicrobial use, and mortality in pediatric patients. Methods: A retrospective single -center study was performed on pediatric inpatients under 19 years old who received systemic antimicrobial treatment from 2001 to 2019. A pediatric infectious disease attending physician started ASP in January 2008. The study period was divided into the pre -intervention (2001-2008) and the post -intervention (2009-2019) periods. The amount of antimicrobial use was defined as days of therapy per 1,000 patientdays, and the differences were compared using delta slope (= changes in slopes) between the two study periods by an interrupted time -series analysis. The proportion of resistant pathogens and the 30 -day overall mortality rate were analyzed by the chi 2 . Results: The proportion of extended -spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae bacteremia increased from 17% (39 of 235) in the pre -intervention period to 35% (189 of 533) in the post -intervention period ( P < 0.001). The total amount of antimicrobial use significantly decreased after the introduction of ASP (delta slope value = -16.5; 95% confidence interval [CI], -30.6 to -2.3; P = 0.049). The 30 -day overall mortality rate in patients with bacteremia did not increase, being 10% (55 of 564) in the pre -intervention and 10% (94 of 941) in the post -intervention period ( P = 0.881). Conclusion: The introduction of ASP for pediatric patients reduced the delta slope of the total antimicrobial use without increasing the mortality rate despite an increased incidence of ESBL-producing gram -negative bacteremia. Kim, Kyung-Ran; Park, Hyo Jung; Baek, Sun -Young; Choi, Soo -Han; Lee, Byung-Kee; Kim, Soojin; Kim, Jong Min; Kang, Ji-Man; Kim, Sun-Ja; Choi, Sae Rom; Kim, Dongsub; Choi, Joon-sik; Yoon, Yoonsun; Park, Hwanhee; Kim, Doo Ri; Shin, Areum; Kim, Seonwoo; Kim, Yae-Jean Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, Seoul, South Korea; Samsung Med Ctr, Dept Pharm, Seoul, South Korea; Sungkyunkwan Univ, Sch Pharm, Suwon, South Korea; Samsung Med Ctr, Res Inst Future Med, Seoul, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Pediat, Sch Med, Pusan, South Korea; Seoulsan Boram Hosp, Dept Pediat, Ulsan, South Korea; Samsung Dream Pediat Clin, Suwon, South Korea; Myongji Hosp, Dept Pediat, Goyang, South Korea; Yonsei Univ, Severance Childrens Hosp, Dept Pediat, Coll Med, Seoul, South Korea; Samsung Dream Pediat Clin, Jeju, South Korea; Wonju Citizen Clin, Wonju, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Pediat, Sch Med, Daegu, South Korea; Gangnam Severance Hosp, Dept Pediat, Seoul, South Korea; Korea Univ, Guro Hosp, Dept Pediat, Coll Med, Seoul, South Korea; Soonchunhyang Univ, Bucheon Hosp, Dept Pediat, Coll Med, Bucheon, South Korea; LSK Global PS, Acad Res Serv Headquarter, Seoul, South Korea; Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul, South Korea; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Samsung Med Ctr, Dept Pediat,Sch Med, 115 Irwon Ro, Seoul 06355, South Korea KIM, JIN/I-6927-2019; Yoon, Yoonsun/AAI-9275-2021; Park, Jinkyeong/GLV-1649-2022; Kim, Junetae/AAS-1234-2021; Kim, Jong-Min/J-5435-2012; Doori, Kim/HPC-3877-2023; kim, jong-eun/B-3550-2017 57190005709; 57221071745; 57203575696; 55841482200; 59153502600; 59153738100; 57022641100; 56587136500; 57203754693; 57203744913; 57205248455; 57205245521; 57217112409; 57208545075; 57217148489; 58475791700; 57196231483; 7410198066 yaejeankim@skku.edu; JOURNAL OF KOREAN MEDICAL SCIENCE J KOREAN MED SCI 1011-8934 1598-6357 39 21 SCIE MEDICINE, GENERAL & INTERNAL 2024 2.3 25.2 0 2025-04-16 0 0 Antimicrobial Stewardship Program; Pediatric Patients; Pediatric Infectious Disease Attending Physician; Antimicrobial Use; Antimicrobial-Resistant Pathogens INFECTIOUS-DISEASES SOCIETY; HEALTH-CARE EPIDEMIOLOGY; ANTIBIOTIC USE; RESISTANCE; INTERVENTIONS; GUIDELINES; REGRESSION; HOSPITALS; AMERICA; QUALITY Antimicrobial Stewardship Program; Antimicrobial Use; Antimicrobial-Resistant Pathogens; Pediatric Infectious Disease Attending Physician; Pediatric Patients Adolescent; Anti-Bacterial Agents; Antimicrobial Stewardship; Bacteremia; Child; Child, Preschool; Escherichia coli; Female; Hospitals, Pediatric; Humans; Infant; Interrupted Time Series Analysis; Klebsiella pneumoniae; Male; Retrospective Studies; antiinfective agent; adolescent; antimicrobial stewardship; bacteremia; child; drug effect; drug therapy; epidemiology; Escherichia coli; female; human; infant; isolation and purification; Klebsiella pneumoniae; male; microbiology; mortality; pediatric hospital; preschool child; retrospective study English 2024 2024-06-03 10.3346/jkms.2024.39.e172 바로가기 바로가기 바로가기 바로가기
Article Near-Infrared Organic Phototransistors with Solution-Processable Acid Molecule-Bound Small Molecule Complexes Here we report near-infrared (NIR) light-detecting organic phototransistors (OPTRs) with a gate-sensing layer (GSL) of solution-processable acid molecule-bound small molecule complexes that were prepared by reactions of 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPSA) and tris(4-aminophenyl)amine (TAPA). The reaction time between TAPA and AMPSA was varied to investigate its influence on the optical absorption and device performance. Results showed that the reaction, leading to the TAPA:AMPSA complexes, proceeded gradually with time by changing the solution color from dark green to light black. The resulting TAPA:AMPSA films exhibited additionally generated optical absorptions in the wavelength range of 600 similar to 1100 nm. The transistor test revealed that the devices with the 3 h-reacted TAPA:AMPSA layers delivered the highest drain current (1.01 mu A) with a reasonable on/off ratio (1.7 x 10(4)). The OPTRs with the wet-coated TAPA:AMPSA GSLs could stably detect three different NIR lights (780, 850, and 905 nm) with a maximum photoresponsivity of 94.2 mA/W (905 nm). The TAPA:AMPSA complexes could be solution-coated on poly(ethylene naphthalene) film substrates, leading to flexible OPTRs that could successfully detect the NIR light. Lee, Sooyong; Kim, Hwajeong; Kim, Youngkyoo Kyungpook Natl Univ, KNU Inst Nanophoton Applicat KINPA, Dept Chem Engn, Organ Nanoelect Lab, Daegu 41566, South Korea; Natl Univ, KNU Inst Nanophoton Applicat KINPA, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Environm Sci & Technol, Prior Res Ctr, Daegu 41566, South Korea 55421486100; 15520531700; 10340424400 ykimm@knu.ac.kr; ACS APPLIED ELECTRONIC MATERIALS ACS APPL ELECTRON MA 2637-6113 6 9 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY 2024 4.7 25.3 0 2025-05-07 0 0 organic phototransistor; NIR; wet-processable; small molecule; TAPA:AMPSA CONJUGATED POLYMERS; HIGH PHOTORESPONSE; BROAD-BAND; PERFORMANCE; PHOTODETECTORS; ULTRAVIOLET; TRANSISTORS; CHANNEL; ARRAY NIR; organic phototransistor; small molecule; TAPA:AMPSA; wet-processable Optical films; Acid molecules; Near Infrared; Near infrared light; Near-infrared; Organic phototransistors; Processable; Small molecules; Solution processable; Tris(4-aminophenyl)amine:2-acrylamido-2-methyl-1-propanesulphonic acid; Wet-processable; Color films English 2024 2024-09-09 10.1021/acsaelm.4c00921 바로가기 바로가기 바로가기 바로가기
Article Nonenzymatic Glucose Sensors Based on Nanoporous Copper Thin Films Fabricated by Laser-Induced Photoreduction Diabetes, a chronic metabolic disease affecting millions of people worldwide, necessitates the development of low-cost and reliable nonenzymatic glucose sensors for effective diabetes management on a global scale. This paper presents an approach using laser processing to fabricate nonenzymatic glucose sensors based on nanoporous Cu thin films (CuTFs). By subjecting a CuO nanorod array to a laser-induced photoreduction (LIPR) process, a highly efficient and sensitive glucose sensor is achieved through the transformation into a nanoporous CuTF. The nanoporous CuTF-based glucose sensor exhibits exceptional sensitivity, with a response of approximately 2.2 mA mM(-1) cm(-2), and an impressively low detection limit of 0.025 mu M. Furthermore, the sensor demonstrates remarkable stability, retaining 96% of its initial current response throughout a comprehensive 15-day evaluation. Additionally, the sensor exhibits excellent selectivity, effectively distinguishing glucose from interfering substances, such as ascorbic acid or uric acid, thereby establishing its reliability for glucose-sensing applications. Furthermore, the CuTF-based glucose sensor is applied to a human sweat-based noninvasive glucose sensor. The utilization of the LIPR process for fabricating the nanoporous CuTF holds great potential in advancing the field of advanced glucose-sensing technologies. Lee, Jehoon; Kong, Heejung; Kim, Hyeonwoo; Ko, Seonmi; Mun, Jonghwan; Yeo, Junyeob Kyungpook Natl Univ, Dept Phys, Novel Appl Nano Opt Lab, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea ; Kong, Heejung/CAG-1032-2022; Yeo, Junyeob/I-1287-2013 58150655100; 57552927300; 57223908123; 58110540600; 57555832500; 58692645200 junyeob@knu.ac.kr; ACS APPLIED ELECTRONIC MATERIALS ACS APPL ELECTRON MA 2637-6113 6 2 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY 2024 4.7 25.3 0.61 2025-05-07 3 2 nonenzymatic glucose sensors; human sweat sensors; laser processing; copper oxide nanorod arrays; copper thin films ELECTRODE; ARRAYS; CU2O copper oxide nanorod arrays; copper thin films; human sweat sensors; laser processing; nonenzymatic glucose sensors Ascorbic acid; Fabrication; Glucose; Glucose sensors; Nanorods; Oxide films; Thin films; Copper oxide nanorod array; Copper thin film; Cu thin film; Human sweat sensor; Laser induced; Laser process; Nano-porous; Nano-rod arrays; Non-enzymatic glucose sensors; Photo reduction; Copper oxides English 2024 2024-02-07 10.1021/acsaelm.3c01610 바로가기 바로가기 바로가기 바로가기
Article Pronounced Light Insensitivity in Low-Voltage n-Channel Organic Field-Effect Transistors with Channel Layers of Dinitrobenzothiadiazole-Containing Conjugated Polymer A light insensitivity in organic field-effect transistors (OFETs) is crucial for use under ambient light conditions that can cause additional current flow in devices leading to unexpected noises. Here, we report low-voltage driving n-channel OFETs, featuring very low light sensitivity, with a channel layer consisting of dinitrobenzothiadiazole-containing conjugated polymer, poly[{2,5-bis(2-octyldodecyl)-3,6-bis(thien-2-yl)-pyrrolo[3,4-c]pyrrole-1,4-diyl}-co-{2,2 '-(5,6-dinitro-2,1,3-benzothiadiazole)-5,5 '-diyl}] (PODTPPD-DNBT). The PODTPPD-DNBT polymer, synthesized via the Stille reaction of two comonomers, showed an optical absorption up to 1100 nm and a lowest unoccupied molecular orbital (LUMO) energy of 4.41 eV. The OFET devices with the PODTPPD-DNBT channels exhibited n-channel-mode transistor behaviors at a low voltage (<= 5 V) and very slightly increased drain current under illumination with strong near-infrared (NIR, wavelength = 905 nm, intensity = 5.96 mW/cm2) and simulated solar light (intensity = 100 mW/cm2). The PODTPPD-DNBT channel layers delivered very low photoresponsivity of 6.95 mA/W under the NIR light, which is less than 1% compared to the theoretical maximum value of 730 mA/W, and 2800% lower photoresponsivity (0.3 mA/W) compared to the same backbone polymer (PODTPPD-BT) without dinitro groups under the simulated solar light. Son, Youjeong; Kim, Taehoon; Kim, Hwajeong; Kim, Youngkyoo Kyungpook Natl Univ, Organ Nanoelect Lab, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Nanophoton Applicat KINPA, Dept Chem Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Energy Convergence & Climate Change, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Global Climate Change & Energy, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Environm Sci & Technol, Prior Res Ctr, Daegu 41566, South Korea ykimm@knu.ac.kr; ACS APPLIED ELECTRONIC MATERIALS ACS APPL ELECTRON MA 2637-6113 7 1 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY 2024 4.7 25.3 0 organic field-effect transistors; light insensitivity; n-channel; n-type conjugated polymer; dinitrobenzothiadiazole; low voltage DIKETOPYRROLOPYRROLE; SEMICONDUCTORS English 2024 2024-12-26 10.1021/acsaelm.4c01473 바로가기 바로가기 바로가기
Article Thermoelectric and Magnetic Properties of Biphasic ZrFe0.5Ni0.5Sb Double Half-Heusler and ZrNiSb Half-Heusler Induced by Co Doping Improving the efficiency of upcoming thermoelectric (TE) materials and exploring their potential for various niche applications are among the promising strategies for addressing the challenges that impede the commercialization of traditional TE materials. This work reports the results of efforts to improve the performance of the recently optimized ZrFe0.4Ni0.6Sb double half-Heusler (DhH) by cobalt (Co) doping. The synthesized ZrFe0.4-yCoyNi0.6Sb samples exhibit phase separation into coherent biphasic DhH and ZrNiSb phases with greatly improved electrical conductivity, which increases from similar to 400 S/cm in sample y = 0 to similar to 3886 S/cm in sample y = 0.4 at room temperature. In addition to the suppression of bipolar conduction, the thermal conductivity also decreases by similar to 18% in sample y = 0.1 compared to sample y = 0, which can be attributed to the enhanced phonon scattering and leads to an increase in peak zT from 0.33 in sample y = 0 to 0.37 in sample y = 0.1 at 973 K. Unfortunately, higher doping concentrations not only deteriorate the Seebeck coefficient but also excessively increase the electronic and lattice thermal conductivities, leading to lower zT values in the samples y > 0.1. By synthesizing and analyzing the (ZrFe0.4Ni0.6NiSb)(1-z) + (ZrNiSb)(z) samples, it is confirmed that the ZrNiSb phases are responsible for the appalling TE performance in the y > 0.1 samples. Further investigation using the recently restructured single parabolic model shows that the ZrFe0.4Ni0.6NiSb system was already overdoped before Co doping, which explains the reason for the resulting PF decrease. Finally, the ferromagnetic nature and tunable magnetism of the synthesized samples are revealed by using a vibrating sample magnetometer to study their magnetism, expanding their range of potential niche applications in spintronics. Kahiu, Joseph Ngugi; Kihoi, Samuel Kimani; Kim, Hyunji; Lee, Ho Seong Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea Kihoi, Samuel Kimani/IUM-8515-2023 57222096169; 57208396874; 57208408040; 55706810400 hs.lee@knu.ac.kr; ACS APPLIED ELECTRONIC MATERIALS ACS APPL ELECTRON MA 2637-6113 6 3 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;MATERIALS SCIENCE, MULTIDISCIPLINARY 2024 4.7 25.3 1.52 2025-05-07 5 5 Zr2FeNiSb2; phase separation; magnetic semiconductors; phonon scattering; modulation doping effect THERMAL-CONDUCTIVITY; PHASE-SEPARATION; ENHANCEMENT; PERFORMANCE magnetic semiconductors; modulation doping effect; phase separation; phonon scattering; Zr<sub>2</sub>FeNiSb<sub>2</sub> Cobalt compounds; Iron compounds; Magnetic semiconductors; Nickel compounds; Phase separation; Phonon scattering; Semiconductor doping; Thermal conductivity; Zirconium compounds; Cobalt doping; Doping effects; Half-heusler; Modulation doping; Modulation doping effect; Niche applications; Synthesised; Thermo-Electric materials; Thermoelectric; Thermoelectric material; Phonons English 2024 2024-03-06 10.1021/acsaelm.3c01749 바로가기 바로가기 바로가기 바로가기
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