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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Selective neurodegeneration of the hippocampus caused by chronic cerebral hypoperfusion: F-18 FDG PET study in rats | Background Chronic cerebral hypoperfusion (CCH) is known to induce Alzheimer's disease (AD) pathology, but its mechanism remains unclear. The purpose of this study was to identify the cerebral regions that are affected by CCH, and to evaluate the development of AD pathology in a rat model of CCH. Methods A rat model of CCH was established by bilaterally ligating the common carotid arteries in adult male rats (CCH group). The identical operations were performed on sham rats without arteries ligation (control group). Regional cerebral glucose metabolism was evaluated at 1 and 3 months after bilateral CCA ligation using positron emission tomography with F-18 fluorodeoxyglucose. The expression levels of amyloid beta 40 (A beta 40), amyloid beta 42 (A beta 42), and hyperphosphorylated tau were evaluated using western blots at 3 months after the ligation. Cognitive function was evaluated using the Y-maze test at 3 months after the ligation. Results At 1 month after the ligation, cerebral glucose metabolism in the entorhinal, frontal association, motor, and somatosensory cortices were significantly decreased in the CCH group compared with those in the control group. At 3 months after the ligation, cerebral glucose metabolism was normalized in all regions except for the anterodorsal hippocampus, which was significantly decreased compared with that of the control group. The expression of A beta 42 and the A beta 42/40 ratio were significantly higher in the CCH group than those in the control group. The phosphorylated-tau levels of the hippocampus in the CCH group were significantly lower than those in the control group. Cognitive function was more impaired in the CCH group than that in the control group. Conclusion Our findings suggest that CCH causes selective neurodegeneration of the anterodorsal hippocampus, which may be a trigger point for the development of AD pathology. | Lee, Jung-In; Lim, Ji Sun; Hong, Jeong-Ho; Kim, Shin; Lee, Sang-Woo; Ji, Hyun Dong; Won, Kyoung Sook; Song, Bong-Il; Kim, Hae Won | Keimyung Univ, Dept Nucl Med, Dongsan Hosp, Daegu, South Korea; Keimyung Univ, Dept Neurol, Dongsan Hosp, Daegu, South Korea; Keimyung Univ, Dept Immunol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Keimyung Univ, Inst Med Sci, Daegu, South Korea | Hong, Jeong-Ho/T-8099-2018; Kim, Shin/D-1669-2013; lee, sangwoo/KUD-1906-2024; Lee, Jung-In/ABB-6667-2020; Song, Bong-il/LIC-9102-2024 | 57211162126; 57202909530; 55931654800; 57210866288; 57196249819; 57191592819; 7005951440; 36164442800; 55739523500 | hwkim.nm@gmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 2 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.5 | 2025-06-25 | 6 | 7 | CHRONIC BRAIN HYPOPERFUSION; WHITE-MATTER LESIONS; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; MOUSE MODEL; MEMORY; DEMENTIA; HYPOXIA; ACTIVATION; PATHOLOGY | Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Carotid Arteries; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Hippocampus; Male; Maze Learning; Peptide Fragments; Positron-Emission Tomography; Rats; Rats, Wistar; tau Proteins; amyloid beta protein[1-40]; amyloid beta protein[1-42]; fluorodeoxyglucose f 18; tau protein; amyloid beta protein; amyloid beta protein[1-40]; amyloid beta-protein (1-42); fluorodeoxyglucose f 18; glucose; peptide fragment; tau protein; adult; animal experiment; animal model; animal tissue; Article; brain metabolism; brain perfusion; carotid artery ligation; cognition; common carotid artery; controlled study; glucose metabolism; hippocampus; infant; male; nerve degeneration; neuroimaging; nonhuman; positron emission tomography; protein expression level; protein phosphorylation; rat; sham procedure; Western blotting; Y-maze test; Alzheimer disease; animal; brain; carotid artery; chemistry; diagnostic imaging; disease model; hippocampus; maze test; metabolism; pathology; surgery; Wistar rat | English | 2022 | 2022-02-10 | 10.1371/journal.pone.0262224 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Serological evaluation of patients with coronavirus disease-2019 in Daegu, South Korea | Background Early and accurate detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical to prevent spread of the infection. Understanding of the antibody response to SARS-CoV-2 in patients with coronavirus disease 2019 (COVID-19) is insufficient, particularly in relation to those whose responses persist for more than 1 month after the onset of symptoms. We conducted a SARS-CoV-2 antibody test to identify factors affecting the serological response and to evaluate its diagnostic utility in patients with COVID-19. Methods and finding We collected 1,048 residual serum samples from 396 patients with COVID-19 confirmed by real-time reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. The samples had been used for routine admission tests in six healthcare institutions in Daegu. Antibody to SARS-CoV-2 was analyzed and the cutoff index (COI) was calculated for quantitative analysis. The patients' information was reviewed to evaluate the relationship between antibody positivity and clinical characteristics. The anti-SARS-CoV-2 antibody positivity rate was 85% and the average COI was 24.3. The positivity rate and COI increased with time elapsed since symptom onset. Anti-SARS-CoV-2 antibody persisted for at least 13 weeks after symptom onset at a high COI. There was a significant difference in anti-SARS-CoV-2 antibody positivity rate between patients with and without symptoms, but not according to sex or disease course. The descending COI pattern at weeks 1 to 5 after symptom onset was significantly more frequent in patients who died than in those who recovered. Conclusions Anti-SARS-CoV-2 antibody persisted for at least 13 weeks at a high COI in patients with COVID-19. A decreasing COI pattern up to fifth week may be associated with a poor prognosis of COVID-19. As new treatments and vaccines are introduced, it is important to monitor continuously the usefulness of anti-SARS-CoV-2 antibody assays. | Park, Sunggyun; Chang, Soon Hee; Lee, Jae Hee; Lee, Jong Ho; Ham, Ji Yeon; Kim, Yu Kyung; Kim, Sang-Gyung; Ryoo, Nam Hee | Keimyung Univ, Dept Lab Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Clin Pathol, Korea, South Korea; Keimyung Univ, Dept Lab Med, Daegu Dongsan Hosp, Daegu, South Korea; Yeungnam Univ, Dept Lab Med, Coll Med, Daegu, South Korea; Daegu Catholic Univ Hosp, Dept Lab Med, Daegu, South Korea | ; Kim, Mi-Kyung/E-8682-2012; Kim, Eun/AAS-6706-2020 | 57216947436; 57222602055; 57226163939; 57193676397; 56464754800; 9237571900; 7601590190; 7801573357 | namhryoo@gmail.com; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.14 | 2025-06-25 | 2 | 2 | Aged; Antibodies, Viral; COVID-19; COVID-19 Nucleic Acid Testing; COVID-19 Serological Testing; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Real-Time Polymerase Chain Reaction; Republic of Korea; Reverse Transcriptase Polymerase Chain Reaction; SARS-CoV-2; Sensitivity and Specificity; immunoglobulin G; immunoglobulin M; virus antibody; adult; antibody response; Article; controlled study; coronavirus disease 2019; COVID-19 serological testing; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; female; human; infection prevention; intermethod comparison; major clinical study; male; middle aged; positivity rate; prognosis; quantitative analysis; real time reverse transcription polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2; South Korea; virus detection; aged; blood; diagnosis; enzyme linked immunosorbent assay; epidemiology; genetics; immunology; procedures; real time polymerase chain reaction; reverse transcription polymerase chain reaction; sensitivity and specificity | English | 2022 | 2022-01-20 | 10.1371/journal.pone.0262820 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Survey of overwintering Halyomorpha halys (Hemiptera: Pentatomidae) in ports of export and natural landscapes surrounding the ports in Republic of Korea | Halyomorpha halys (Hemiptera: Pentatomidae), an important agricultural and nuisance pest, is highly invasive with peculiar hiding behavior in human-made structures for overwintering. To evaluate the contamination risk of overwintering H. halys in non-agricultural export goods, we conducted a two-year field survey in Republic of Korea to locate overwintering H. halys in two major ports of export, Ulsan and Pyeongtaek ports, and monitored both active and overwintering H. halys population levels with varying distances from the ports ranging from 1 km to 48 km. First, we deployed wooden shelters in the two ports to catch dispersing H. halys for overwintering and conducted visual inspections for human-made structures in the ports to locate overwintering H. halys. In addition, we sampled dead trees to find overwintering H. halys in wooded areas. Second, we monitored active H. halys populations using pheromone traps with varying distances from the ports. From the survey of overwintering populations, no H. halys was collected from wooden shelters deployed in the two ports. However, we found four adults overwintering in human-made structures in Pyeongtaek port in the first year of survey. One dead adult was also found from a dead tree located in a wooded area adjacent to Pyeongtaek port in the second year. For active populations, results of pheromone trapping indicated that H. halys populations were present during autumn dispersal period not only in agricultural areas, but also in wooded areas adjacent to the two ports. This study reports for the first time that overwintering H. halys were found from the inside the port of export in its native areas with a low density. The results were discussed for evaluating contamination risk of overwintering H. halys in export goods shipping from the Republic of Korea. | Song, Hyunsung; Jung, Minhyung; Hwang, Seoyul; Kim, Jiseok; Kim, Donghun; Lee, Doo-Hyung | Gachon Univ, Dept Life Sci, Seongnam Si, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Vector Entomol, Sangju, Gyeongsangbok D, South Korea; Kyungpook Natl Univ, Grad Sch Plant Protect & Quarantine, Dept Plant Protect & Quarantine, Daegu, South Korea | 57209221785; 57188649986; 57286510400; 57870544800; 56115927500; 55649570824 | dklome2018@knu.ac.kr;dl343@gachon.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 8 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.07 | 2025-06-25 | 1 | 1 | MARMORATED STINK BUG; GENETIC DIVERSITY; NORTH-AMERICA; BIOLOGY; BEHAVIOR; ECOLOGY; EUROPE; PEST; ASIA | Animals; Healthy Life Expectancy; Heteroptera; Humans; Pheromones; Republic of Korea; Trees; pheromone; adult; animal tissue; Article; autumn; contamination; controlled study; female; Halyomorpha halys; Hemiptera; male; nonhuman; overwintering; risk; rural area; South Korea; animal; Heteroptera; human; tree | English | 2022 | 2022-08-26 | 10.1371/journal.pone.0270532 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Systematic Assessment of the Positive Role of Arabidopsis thaliana GROWTH-REGULATING FACTORs in Regulation of Cell Proliferation During Leaf Growth | Leaf growth and development are primarily driven by cell proliferation and expansion. Among a number of genes involved in the regulation of cell proliferation, the GROWTH-REGULATING FACTOR (GRF) transcription factors have been established to act as positive regulators of cell proliferation and leaf growth in angiosperms. While the Arabidopsis thaliana GRF family comprises nine members, not all members of the family have been experimentally confirmed for the positive role, not only due to no or only slight changes in leaf size of corresponding single mutants, but also due to unavailability of multiple mutants to overcome the obstacle. Furthermore, some discrepancies and confusion in their roles have been disclosed in the literature. Here, we systemically prepared a series of such multiple mutants and confirmed that all GRF members, except for GRF8, acted as positive regulators of cell proliferation and leaf growth. We also systematically examined the spatio-temporal distribution patterns of all nine GRF proteins in the leaf organ, and found that their distribution patterns were highly reminiscent of the behavior of the cell cycle arrest front. We therefore propose that GRFs play an important role in shaping the arrest front and growth patterns of leaves. | Lee, Gah-Hee; Lee, Byung Ha; Jung, Jae-Hak; Lee, Sang-Joo; Mai, Tran-Thi; Kim, Jeong Hoe | Kyungpook Natl Univ, Dept Biol, Daehak Ro 80, Daegu 41566, South Korea; BHL Seegene Inc, Taewon Bldg 91, Seoul 05548, South Korea | Kim, So-Young/JFS-7698-2023 | 57841777700; 57215105367; 57203377472; 56912102800; 57195308433; 7601377826 | kimjeon4@knu.ac.kr; | JOURNAL OF PLANT BIOLOGY | J PLANT BIOL | 1226-9239 | 1867-0725 | 65 | 5 | SCIE | PLANT SCIENCES | 2022 | 2.9 | 34.9 | 0.78 | 2025-06-25 | 7 | 7 | Arabidopsis thaliana; GROWTH-REGULATING FACTOR; Leaf growth; Cell proliferation; CYCB1;1::GUS | GRF TRANSCRIPTION FACTORS; DEVELOPING LEAVES; MICRORNA MIR396; PLANT-GROWTH; COACTIVATOR; EXPRESSION; MECHANISM; FAMILY; GENE; MORPHOLOGY | Arabidopsis thaliana; Cell proliferation; CYCB1;1::GUS; GROWTH-REGULATING FACTOR; Leaf growth | English | 2022 | 2022-10 | 10.1007/s12374-022-09366-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The impact of non-alcoholic fatty liver disease on sleep apnea in healthy adults: A nationwide study of Korea | Background & aims Nonalcoholic fatty liver disease (NAFLD) is one of the most common health problems worldwide. Sleep apnea (SA) causes cardiovascular and metabolic problems, as well as a significant socioeconomic burden. Although several studies have found that SA causes NAFLD, there is no evidence that NAFLD causes SA. The goal of this study was to look at the relationship between NAFLD and SA in realworld data. Methods We evaluated 334,334 healthy individuals without comorbidities who underwent National Health checkups in the Republic of Korea from 2009 to 2014. NAFLD was defined by a surrogate marker, the fatty liver index (FLI). The association between FLI and SA was analyzed using multivariate Cox proportional hazards regression models. Results During a median followup of 5.3 years, 1,351 patients (0.4%) were newly diagnosed with SA. Subjects were categorized into quartile groups according to FLI (range: Q1, 0-4.9; Q2, 5.0-12.5; Q3, 12.6-31.0; Q4, >31.0). Subjects with higher FLIs had a significantly higher cumulative incidence of SA than those with lower FLIs (Q1, 119 [0.1%]; Q2, 210 [0.3%]; Q3, 339 [0.4%]; Q4, 683 [0.8%]; P < 0.001). Adjusted hazard ratios (HRs) revealed that a higher FLI was independently associated with an increased risk of SA (HR between Q4 and Q1, 4.03; 95% confidence interval, 3.22-5.05; P < 0.001). This association remained statistically significant after further adjustment for Body mass index (BMI) (HR between Q4 and Q1, 2.19; 95% confidence interval, 1.69-2.83; P < 0.001). FLI was significantly associated with an increased risk of new-onset SA regardless of baseline characteristics. Conclusion This study demonstrated that NAFLD, assessed by FLI, was independently associated with increased risk for SA in the healthy Korean population. | Kim, Namkyun; Roh, Jae-Hyung; Lee, Hanbyul; Kim, Doyeon; Heo, Sung Jae | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Chungnam Natl Univ, Sejong Hosp, Sch Med, Dept Cardiol Internal Med, Sejong, South Korea; Chungnam Natl Univ, Div Healthcare Business Dev, Sejong Hosp, Sejong, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu, South Korea | 허, 성재/AAU-3921-2020 | 55887032700; 57216309871; 59107079300; 57813354300; 55822906000 | blueskyhsj@hanmail.net; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.36 | 2025-06-25 | 4 | 5 | STEATOSIS | Adult; Body Mass Index; Humans; Incidence; Non-alcoholic Fatty Liver Disease; Republic of Korea; Risk Factors; Sleep Apnea Syndromes; alcohol; gamma glutamyltransferase; triacylglycerol; adult; alcohol consumption; Article; body mass; cigarette smoking; clinical evaluation; cohort analysis; disease association; fatty liver index; female; follow up; hazard ratio; human; incidence; major clinical study; male; nonalcoholic fatty liver; physical activity; proportional hazards model; risk assessment; sleep disordered breathing; South Korea; waist circumference; complication; nonalcoholic fatty liver; risk factor; sleep disordered breathing; South Korea | English | 2022 | 2022-07-21 | 10.1371/journal.pone.0271021 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Validation of quantitative real-time PCR reference genes and spatial expression profiles of detoxication-related genes under pesticide induction in honey bee, Apis mellifera | Recently, pesticides have been suggested to be one of the factors responsible for the large-scale decline in honey bee populations, including colony collapse disorder. The identification of the genes that respond to pesticide exposure based on their expression is essential for understanding the xenobiotic detoxification metabolism in honey bees. For the accurate determination of target gene expression by quantitative real-time PCR, the expression stability of reference genes should be validated in honey bees exposed to various pesticides. Therefore, in this study, to select the optimal reference genes, we analyzed the amplification efficiencies of five candidate reference genes (RPS5, RPS18, GAPDH, ARF1, and RAD1a) and their expression stability values using four programs (geNorm, NormFinder, BestKeeper, and RefFinder) across samples of five body parts (head, thorax, gut, fat body, and carcass) from honey bees exposed to seven pesticides (acetamiprid, imidacloprid, flupyradifurone, fenitrothion, carbaryl, amitraz, and bifenthrin). Among these five candidate genes, a combination of RAD1a and RPS18 was suggested for target gene normalization. Subsequently, expression levels of six genes (AChE1, CYP9Q1, CYP9Q2, CYP9Q3, CAT, and SOD1) were normalized with a combination of RAD1a and RPS18 in the different body parts from honey bees exposed to pesticides. Among the six genes in the five body parts, the expression of SOD1 in the head, fat body, and carcass was significantly induced by six pesticides. In addition, among seven pesticides, flupyradifurone statistically induced expression levels of five genes in the fat body. | Kim, YeongHo; Kim, Hyemin; Cha, JooHeon; Lee, Si Hyeock; Kim, Young Ho | Kyungpook Natl Univ, Dept Ecol Sci, Sangju, Gyeongbuk, South Korea; Kyungpook Natl Univ, Dept Appl Biol, Sangju, Gyeongbuk, South Korea; Seoul Natl Univ, Dept Agr Biotechnol, Seoul, South Korea | Kim, Young/J-5414-2012; Lee, Sang/R-7470-2019 | 58516491300; 57965331200; 57965439100; 34872664900; 57215211825 | yhkim05@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 11 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.43 | 2025-06-25 | 7 | 6 | INDUCED OXIDATIVE STRESS; POLLEN LOADS; RESIDUES; NEONICOTINOIDS; EXPOSURE; DETOXIFICATION; INSECTICIDES; POPULATIONS; MECHANISMS; NICOTINE | Animals; Bees; Insecticides; Pesticides; Pyridines; Real-Time Polymerase Chain Reaction; Superoxide Dismutase-1; acetamiprid; amitraz; bifenthrin; carbaril; fenitrothion; flupyradifurone; imidacloprid; pesticide; unclassified drug; copper zinc superoxide dismutase; insecticide; pesticide; pyridine derivative; AChE1 gene; adult; animal experiment; Apis mellifera; ARF1 gene; Article; body fat; body regions; CAT gene; controlled study; CYP9Q1 gene; CYP9Q2 gene; CYP9Q3 gene; detoxification; GAPDH gene; gene; gene expression level; gene expression profiling; nonhuman; RAD1a gene; real time polymerase chain reaction; RPS18 gene; RPS5 gene; SOD1 gene; validation study; animal; bee; genetics; metabolism; real time polymerase chain reaction | English | 2022 | 2022-11-10 | 10.1371/journal.pone.0277455 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Comparison of the Analgesic Efficacy of Opioid-Sparing Multimodal Analgesia and Morphine-Based Patient-Controlled Analgesia in Minimally Invasive Surgery for Colorectal Cancer | Background A multimodal analgesia (MMA) protocol has shown the effect of postoperative pain control and reduced the postoperative opioid consumption. However, it was questionable whether MMA could replace opioid-based patient-controlled analgesia (PCA) for postoperative pain control. Therefore, this study aimed to investigate whether an MMA protocol is non-inferior to opioid-based PCA for pain management after a minimally invasive colorectal cancer surgery. Methods A randomized, open-label, non-inferiority clinical trial was conducted on patients undergoing laparoscopic or robotic resection of colorectal cancer. The patients were randomly assigned to either the PCA or MMA group. The MMA protocol included pregabalin, tramadol, wound infiltration, and transversus abdominis plane block. The primary outcome was the numeric rating scale (NRS) score for pain at rest 24 h postoperatively. Results Ninety-seven patients were included in the intention-to-treat analysis. The mean difference in NRS score at rest at 24 h was 0.25 (95% confidence interval, - 0.61 to 1.11). This result demonstrated the non-inferiority of MMA to PCA in our non-inferiority margin (- 1). Compared with the PCA group, the median remifentanil dose (996 vs. 654 mu g; p < 0.001) and time in the post-anesthesia care unit (35 vs. 25 min; p < 0.001) were significantly less in the MMA group. Conclusions Our MMA protocol successfully controlled postoperative pain and was non-inferior to morphine-based PCA based on patient-reported pain intensity, with no significant increase in adverse events. These results will help construct a strategy to reduce conventional opioid prescriptions for pain management after a minimally invasive colorectal cancer surgery. Trial Registration Number Trial Registration Clinical Research Information Service Identifier: KCT0002593 | Yeo, Jinseok; Park, Jun Seok; Choi, Gyu-Seog; Kim, Hye Jin; Kim, Jay Kyoung; Oh, Jinyoung; Park, Soo Yeun | Kyungpook Natl Univ, Dept Anesthesiol & Pain Med, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Dept Colorectal Surg, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea | Park, Joonhong/AAZ-9885-2020; Kim, Hye/W-1059-2019 | 35072322000; 35226761100; 8058759100; 57204567554; 57218347150; 57609999900; 40561578300 | psy-flower@daum.net; | WORLD JOURNAL OF SURGERY | WORLD J SURG | 0364-2313 | 1432-2323 | 46 | 7 | SCIE | SURGERY | 2022 | 2.6 | 35.0 | 2.28 | 2025-06-25 | 11 | 11 | ABDOMINIS PLANE BLOCK; POSTOPERATIVE PAIN; MANAGEMENT; TRAMADOL | Abdominal Muscles; Analgesia, Patient-Controlled; Analgesics, Opioid; Colorectal Neoplasms; Humans; Minimally Invasive Surgical Procedures; Morphine; Pain, Postoperative; Prospective Studies; morphine; narcotic analgesic agent; abdominal wall musculature; colorectal tumor; complication; controlled study; human; minimally invasive surgery; patient controlled analgesia; postoperative pain; procedures; prospective study; randomized controlled trial | English | 2022 | 2022-07 | 10.1007/s00268-022-06473-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Need to restage Korean melanoma patients following publication of the 8th edition of the American Joint Committee on Cancer staging manual | Background: The tumor, nodes and metastasis (TNM) classification and stage grouping have been updated in the 8th edition of the American Joint Committee on Cancer (AJCC) melanoma staging manual. However, restaging all the previous cases are not recommended. Aims: The aims of the study were to investigate the necessity of restaging Korean melanoma patients staged by the previous edition of the AJCC manual. Methods: Differences in the staging criteria of the 7th and 8th editions of the AJCC manual were identified. The staging of 276 primary melanomas from January 2011 to December 2018 was classified by both 7th and 8th editions of the manual and their differences were compared. Results: Staging by 7th and 8th edition of the AJCC manual differed in 64 cases (23.2%). The pathological prognostic staging changed in 35 (12.7%), and 29 (10.5%) had changes in only TNM classification but not the pathological staging. None of the patients needed additional sentinel lymph node biopsy or systemic treatment as a result of restaging. Additional counseling was needed for the patients, because melanoma-specific survival was increased in the 8th edition. Limitations: This is a retrospective study with relatively small number of patients at a single tertiary center in Korea. Conclusion: Assessment of the need for additional sentinel lymph node biopsy or systemic treatment is recommended because of the latest changes in the AJCC melanoma staging manual. Although the restaging of previously staged melanomas is not significantly needed in our patients, still the differences in TNM classification and/or pathological prognostic staging suggest the need to separately recognize the patients previously staged by 7th edition and recently staged by 8th edition. Careful counseling about melanoma-specific survival is needed for Asian patients. | Lee, Hyun Ji; Park, Kyung Duck; Jang, Yong Hyun; Lee, Weon Ju; Lee, Seok-Jong; Kim, Jun Young | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Dermatol, Daegu, South Korea | Lee, Joong/A-5417-2013 | 57207758693; 55767995700; 57016046400; 24474659000; 56013454400; 35310922800 | 198kjy@hanmail.net; | INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY | INDIAN J DERMATOL VE | 0378-6323 | 0973-3922 | 88 | 3 | SCIE | DERMATOLOGY | 2022 | 2.9 | 35.0 | 0 | 2025-06-25 | 0 | 0 | American Joint Committee on Cancer; melanoma; staging; survival; TNM classification | CUTANEOUS MELANOMA; MANAGEMENT | American Joint Committee on Cancer; melanoma; staging; survival; TNM classification | Humans; Melanoma; Neoplasm Staging; Prognosis; Republic of Korea; Retrospective Studies; United States; lactate dehydrogenase; acral lentiginous melanoma; American Joint Committee on Cancer staging manual; Article; Breslow thickness; cancer prognosis; cancer specific survival; cancer staging; distant metastasis; human; human tissue; Korea; local recurrence free survival; lymph node metastasis; major clinical study; melanoma; micrometastasis; practice guideline; retrospective study; sentinel lymph node biopsy; systemic therapy; cancer staging; epidemiology; melanoma; prognosis; South Korea; United States | English | 2022 | 2022 (MAY-JUN) | 10.25259/ijdvl_680_20 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Swift one-stage reconstruction of two adjacent nasal defects with a modified bilobed flap | Lee, Seon Hwa; Kim, Jun Young | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Dermatol, Daegu, South Korea | 57224078421; 35310922800 | 198kjy@hanmail.net; | INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY | INDIAN J DERMATOL VE | 0378-6323 | 0973-3922 | 88 | 6 | SCIE | DERMATOLOGY | 2022 | 2.9 | 35.0 | 0.28 | 2025-06-25 | 1 | 1 | Humans; Nose; Reconstructive Surgical Procedures; Surgical Flaps; acrodynia; aged; basal cell carcinoma; bone graft; case report; clinical article; echography; female; human; human tissue; Letter; physical examination; rhinoplasty; skin transplantation; very elderly; nose; reconstructive surgery; surgical flaps | English | 2022 | 2022 (NOV-DEC) | 10.25259/ijdvl_1201_2021 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | A multicenter, open-label study for efficacy and safety evaluation of anagrelide in patients with treatment-naive, high-risk essential thrombocythemia as a primary treatment | As the discussion of first-line anagrelide treatment is ongoing, we aimed to prospectively examine the efficacy and safety of anagrelide in cytoreduction therapy-naive high risk essential thrombocythemia (ET) patients in Korea. Seventy patients from 12 centers were treated with anagrelide monotherapy for up to 8 weeks, followed up until 24 months. At week 8, 50.0% of the patients were able to achieve platelet < 600 x 10(9)/L, and by 12 months, 55/70 (78.6%) patients stayed on anagrelide, and 40.0% patients showed platelet normalization. 14 patients required additional hydroxyurea (HU) for cytoreduction. The median daily dose of needed HU was 500mg (range 250mg - 1500mg). The efficacy was independent of the somatic mutation status. There were 4 thromboembolic events and 7 bleeding events during the follow-up period. The most common adverse events associated with anagrelide use were headache, followed by palpitation/chest discomfort, edema and generalized weakness/fatigue. 7 patients wished to discontinue anagrelide treatment due to adverse events (3 due to headache; 2 due to edema; 1 due to palpitation and 1 due to skin eruption). All in all, first-line anagrelide treatment showed a favorable response with tolerable safety profiles regardless of somatic mutation status. | Byun, Ja Min; Kim, Ho Young; Nam, Seung-Hyun; Shin, Ho-Jin; Song, Seulki; Park, Jinny; Han, Sang Hoon; Park, Yong; Yuh, Young Jin; Mun, Yeung-Chul; Do, Young Rok; Sohn, Sang Kyun; Bae, Sung Hwa; Shin, Dong-Yeop; Yoon, Sung-Soo | Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Hallym Univ, Dept Internal Med, Med Ctr, Anyang, South Korea; Kyung Hee Univ Gangdong, Dept Internal Med, Seoul, South Korea; Pusan Natl Univ Hosp, Med Res Inst, Sch Med, Dept Internal Med,Div Haematol Oncol, Pusan, South Korea; Seoul Natl Univ Hosp, Canc Res Inst, Seoul, South Korea; Gachon Univ, Dept Internal Med, Div Hematol, Gil Med Ctr, Incheon, South Korea; Jeju Natl Univ, Jeju Natl Univ Hosp, Dept Internal Med, Sch Med, Jeju, South Korea; Korea Univ, Dept internal Med, Div Hematooncol, Sch Med, Seoul, South Korea; Inje Univ, Sanggye Paik Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Mokdong Hosp, Seoul, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Dongsan Hosp, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Catholic Univ, Dept Internal Med, Sch Med, Daegu, South Korea | ; Nam, Seung-Hyun/GYJ-4373-2022; Kim, Ho-Young/HTR-7982-2023; Park, Junsik/KIB-5533-2024; Byun, Ja/AAI-2125-2020; Hyun-Jung, Kim/E-8074-2011 | 57191727590; 57221442234; 55264192100; 16239868400; 57211636999; 35277336100; 56693289900; 7405373234; 7003838456; 7003363716; 8960168300; 13310226800; 56545017400; 36492559200; 7404036304 | shindongyeop@snu.ac.kr;ssysmc@snu.ac.kr; | FRONTIERS IN ONCOLOGY | FRONT ONCOL | 2234-943X | 12 | SCIE | ONCOLOGY | 2022 | 4.7 | 35.1 | 0.09 | 2025-06-25 | 1 | 1 | essential thrombocythemia; high risk; Anagrelide; phase IV clinical trial; myeloproliferative neoplasms | POLYCYTHEMIA-VERA; HYDROXYUREA; MUTATION | Anagrelide; essential thrombocythemia; high risk; myeloproliferative neoplasms; phase IV clinical trial | acetylsalicylic acid; anagrelide; clopidogrel; dabigatran; edoxaban; enoxaparin; hydroxyurea; interferon; adult; aged; alcohol liver cirrhosis; angina pectoris; Article; brain hemorrhage; brain infarction; cardiovascular risk factor; carotid artery obstruction; clinical trial; controlled study; diabetes mellitus; drug efficacy; drug safety; dyslipidemia; dyspepsia; ecchymosis; edema; epigastric pain; epistaxis; fatigue; headache; heart palpitation; hepatitis B; human; human experiment; hypertension; major clinical study; male; multicenter study; observational study; rash; thorax pain; thrombocythemia; thrombosis; thyroid cancer; transient ischemic attack; very elderly; weakness; young adult | English | 2022 | 2022-11-23 | 10.3389/fonc.2022.989984 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Amyloid beta oligomers-induced parkin aggravates ER stress-mediated cell death through a positive feedback loop | Recently, Parkin has been reported to induce endoplasmic reticulum (ER) stress. In addition, amyloid beta oligomers WO), hallmarks of Alzheimer's disease (AD), also increase ER stress in neurons. Because a mutation in the Parkin gene is a well-known predominant cause of familial Parkinson's disease (PD), Parkin has been well studied in PD but has not been well researched in AD. In this study, we investigated the role of MO-mediated Parkin associated with ER stress in AD. For AD-based research, we used MO treatments in mouse hippocampusderived HT-22 cells. We stably expressed Parkin in HT-22 cells to confirm the hypothesis and used siParkin for downregulation of Parkin expression. Moreover, using hippocampi from amyloid precursor protein/presenilin 1/ Tau triple transgenic mice (3xTg-AD mice), which are used for AD models, we confirmed the relationship between ER stress and Parkin in vivo. We observed that ATF4 upregulated MO-increases in Parkin. Parkin overexpression aggravated ER stress in MO-treated HT-22 cells and the hippocampi of 3xTg-AD mice. Parkin downregulation led to no significant change when compared to MO-treated cells. Moreover, Parkin-mediated ER stress was not related to oxidative stress. Our study indicates that MO-induced ATF4 upregulated Parkin levels and that Parkin increases ER stress as a positive feedback loop. Through this study, our findings provide a foundation for future studies on the specific mechanisms related to the role of Parkin in AD. | Kam, Min Kyoung; Kim, Bokyung; Lee, Dong Gil; Lee, Hong Jun; Park, Young-Ho; Lee, Dong-Seok | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu 41566, South Korea; Chungbuk Natl Univ, Res Med & Med Res Inst, Cheongju, Chungbuk, South Korea; E Biogen Inc, Res Inst, Seoul, South Korea; Korea Res Inst Biosci & Biotechnol KRIBB, Futurist Anim Resource & Res Ctr FARRC, Cheongju, South Korea | ; lee, wj/JNR-4926-2023 | 57195564169; 57205869587; 56824532400; 35215736300; 56246852400; 57210068061 | leel@knu.ac.kr;lee1@knu.ac.kr; | NEUROCHEMISTRY INTERNATIONAL | NEUROCHEM INT | 0197-0186 | 1872-9754 | 155 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;NEUROSCIENCES | 2022 | 4.2 | 35.1 | 0.42 | 2025-06-25 | 5 | 5 | Parkin; ATF4; Amyloid beta oligomers; Endoplasmic reticulum stress; Alzheimer's disease | ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; ALZHEIMERS-DISEASE; A-BETA; MITOPHAGY; NEURONS; INHIBITION; ACTIVATION; PROTEASOME; INDUCTION | Alzheimer's disease; Amyloid beta oligomers; ATF4; Endoplasmic reticulum stress; Parkin | Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Death; Endoplasmic Reticulum Stress; Feedback; Mice; Mice, Transgenic; Ubiquitin-Protein Ligases; activating transcription factor 4; amyloid beta protein; amyloid precursor protein; lactate dehydrogenase; oligomer; parkin; presenilin 1; reactive oxygen metabolite; amyloid beta protein; ubiquitin protein ligase; 3XTg mouse; Alzheimer disease; animal cell; animal experiment; animal model; Article; cell death; cell viability; confocal microscopy; cytotoxicity; DNA sequencing; down regulation; endoplasmic reticulum stress; flow cytometry; HT22 cell line; immunohistochemistry; luciferase assay; male; mouse; MTT assay; nonhuman; nucleotide sequence; oxidative stress; polymerase chain reaction; positive feedback; real time polymerase chain reaction; RNA extraction; RNA interference; upregulation; Western blotting; Alzheimer disease; animal; cell death; endoplasmic reticulum stress; feedback system; genetics; metabolism; transgenic mouse | English | 2022 | 2022-05 | 10.1016/j.neuint.2022.105312 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Busulfan and thiotepa as a conditioning regimen for autologous stem cell transplantation in patients with multiple myeloma: A study of the Korean Multiple Myeloma Working Party (KMMWP-1801 study) | BackgroundAutologous stem cell transplantation (ASCT) remains the standard of care for patients with newly diagnosed multiple myeloma (MM). Several attempts to improve the efficacy of conditioning regimens have been conducted in MM, but no more effective regimen than conventional high-dose melphalan has been introduced. ObjectiveIn this study, the efficacy and toxicity of busulfan and thiotepa (BuTT) and those of high-dose melphalan (HD-MEL) were compared retrospectively as a conditioning regimen for ASCT in patients with MM. Study designIncluded in the analysis were 114 patients who received BuTT and 114 patients who received HD-MEL treatment between March 2008 and May 2020. The BuTT regimen consisted of intravenous thiotepa 5 mg/kg once a day from days 7 to 6, followed by intravenous busulfan 3.2 mg/kg once a day from days 5 to 3. The HD-MEL conditioning regimen consisted of melphalan 100 mg/m(2) once a day from days 3 to 2. ResultsThe overall response rate after ASCT did not differ between BuTT and HD-MEL (94.7% in BuTT vs. 97.4% in HD-MEL, p = 0.333). After a median follow-up of 47.6 months, progression-free survival (PFS) tended to be longer in the BuTT group (median PFS, 41.5 months vs. 30.3 months; hazard ratio (HR), 0.706; 95% confidence interval (CI), 0.497-1.004, p = 0.053). In the subgroup analysis of patients who did not proceed to maintenance or consolidation treatment after ASCT, the difference in PFS became more significant (median PFS, 41.5 months vs. 24.4 months; HR, 0.621; 95% CI, 0.388-0.993; p = 0.047). Additionally, the BuTT group had fewer adverse events, such as grade 3 or 4 stomatitis and diarrhea, than the HD-MEL group (stomatitis, 10.5% vs. 23.7%, p = 0.013; diarrhea, 10.5% vs. 25.4%, p = 0.005). There was no difference in the occurrence of venous-occlusive disease (2.6% in BuTT vs. 0.9% in HD-MEL, p = 0.622). ConclusionOur study results suggest that BuTT is an effective alternative conditioning regimen with reduced toxicity in patients with newly diagnosed MM. | Song, Ga-Young; Jung, Sung-Hoon; Kim, Jin Seok; Eom, Hyeon Seok; Moon, Joon Ho; Yhim, Ho-Young; Kim, Kihyun; Min, Chang-Ki; Lee, Je-Jung | Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Hwasun, South Korea; Yonsei Univ, Severance Hosp, Coll Med, Seoul, South Korea; Natl Canc Ctr, Goyang Si, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Daegu, South Korea; Chonbuk Natl Univ, Div Hematol Oncol, Med Sch, Jeonju, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Seoul, South Korea; Catholic Univ Korea, Seoul St Marys Hematol Hosp, Seoul St, Seoul, South Korea | Lee, Jung-Hye/F-6974-2013; Kim, Kihyun/D-5175-2013; KIM, JIN/I-6927-2019 | 57193027251; 55511978300; 55032033600; 35268272400; 56568642700; 35785270600; 57199440300; 57224962914; 7601478211; 36144600500 | drjejung@chonnam.ac.kr;ckmin@catholic.ac.kr; | FRONTIERS IN ONCOLOGY | FRONT ONCOL | 2234-943X | 12 | SCIE | ONCOLOGY | 2022 | 4.7 | 35.1 | 0.47 | 2025-06-25 | 5 | 5 | multiple myeloma; autologous stem cell transplantation; conditioning regimen; busulfan and melphalan; melphalan conditioning | HIGH-DOSE MELPHALAN; VENOOCCLUSIVE DISEASE; CYCLOPHOSPHAMIDE TBC; PREPARATIVE REGIMEN; INTENSIVE REGIMEN; MARROW; LYMPHOMA; LIVER | autologous stem cell transplantation; busulfan and melphalan; conditioning regimen; melphalan conditioning; multiple myeloma | alanine aminotransferase; aspartate aminotransferase; beta 2 microglobulin; bortezomib; busulfan; creatinine; cyclophosphamide; dexamethasone; hemoglobin; immunoglobulin A; immunoglobulin G; immunoglobulin M; lactate dehydrogenase; melphalan; thalidomide; thiotepa; vincristine; Article; autologous stem cell transplantation; cancer survival; diarrhea; drug efficacy; drug megadose; ECOG Performance Status; follow up; hematologic disease; hospitalization; human; major clinical study; multiple myeloma; neutrophil count; overall response rate; overall survival; platelet count; progression free survival; retrospective study; stomatitis; treatment response | English | 2022 | 2022-08-30 | 10.3389/fonc.2022.959949 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Long-term oncological outcomes of oncoplastic breast-conserving surgery after a 10-year follow-up - a single center experience and systematic literature review | AimWhile many studies reported the oncological outcomes of oncoplastic breast-conserving surgery (OBCS), there were inherent differences in the study population, surgeons' expertise, and classifications of techniques used. There were also limited studies with long term follow up oncological outcomes beyond 5 years. This current study aimed to compare long-term oncological outcomes of ipsilateral breast tumor recurrence (IBTR) disease-free survival (DFS) and overall survival (OS) following conventional and oncoplastic breast-conserving surgery using volume displacement and replacement techniques. MethodsBetween 2009 and 2013, 539 consecutive patients who underwent breast conservation surgery including 174 oncoplastic and 376 conventional procedures were analysed. A systematic review of studies with at least five years of median follow up were performed to compare long term oncological outcomes. ResultsAt a median follow-up of 82.4 months, there were 23 (4.2%) locoregional recurrences, 17 (3.2%) metachronous contralateral breast cancer, 26 (4.8%) distant metastases, and 13 (2.4%) deaths. The hazard ratio of OBCS for IBTR, DFS and OS were 0.78 (95% confidence interval [CI] 0.21-2.94, p=0.78), 1.59 (95% CI, 0.88 to 2.87, p=0.12), and 2.1 (95% CI, 0.72 to 5.9, p=0.17) respectively. The 10-year IBTR-free, DFS and OS rate were 97.8%, 86.2%, and 95.7% respectively. ConclusionThere remained a dearth in well-balanced comparative studies with sufficient long-term follow-up, and our study reported long-term oncological outcomes for OBCS which were favourable of either VD or replacement techniques. | Hing, Jun Xian; Kang, Byeong Ju; Keum, Hee Jung; Lee, Jeeyeon; Jung, Jin Hyang; Kim, Wan Wook; Yang, Jung Dug; Lee, Joon Seok; Park, Ho Yong | Kyungpook Natl Univ, Kyungpook Natl Univ Chilgok Hosp, Sch Med, Dept Surg, Daegu, South Korea; Changi Gen Hosp, Dept Gen Surg, Div Breast Surg, Singapore, Singapore; Singapore Hlth Serv Pte Ltd, Singhealth Duke NUS Breast Ctr, Singapore, Singapore; Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu, South Korea | Yang, Jung/R-7806-2019; Lee, Jong-Mok/KVY-9550-2024; LEE, JIN/Q-3108-2018; PARK, JUN-YOUNG/P-5981-2015 | 57216917884; 57279815300; 57221998716; 37079213100; 57209310173; 26023273400; 55171704700; 56496041000; 56564377200 | phy123@knu.ac.kr; | FRONTIERS IN ONCOLOGY | FRONT ONCOL | 2234-943X | 12 | SCIE | ONCOLOGY | 2022 | 4.7 | 35.1 | 0.19 | 2025-06-25 | 2 | 2 | oncoplastic; breast-conserving surgery; oncological outcomes; volume displacement; volume replacement | VOLUME REPLACEMENT; CANCER-PATIENTS; PARTIAL MASTECTOMY; CONSERVATION SURGERY; SURGICAL TECHNIQUES; RECONSTRUCTION; INSTITUTION; IMMEDIATE; SAFE | breast-conserving surgery; oncological outcomes; oncoplastic; volume displacement; volume replacement | English | 2022 | 2022-08-09 | 10.3389/fonc.2022.944589 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Optimization of spectrally selective 180° radiofrequency pulse timings in J-difference editing (MEGA) of lactate | Purpose: J-Difference editing (MEGA) provides an effective spectroscopic means of selectively measuring low-concentration metabolites having weakly coupled spins. The fractional inphase and antiphase coherences are determined by the radiofrequency (RF) pulses and inter-RF pulse intervals of the sequence. We examined the timings of the spectrally selective editing 180 degrees pulses (E180) in MEGA-PRESS to maximize the edited signal amplitude in lactate at 3T. Methods: The time evolution of the lactate spin coherences was analytically and numerically calculated for non-volume localized and single-voxel localized MEGA sequences. Single-voxel localized MEGA-PRESS simulations and phantom experiments were conducted for echo time (TE) 60-160 ms and for all possible integer-millisecond timings of the E180 pulses. Optimized E180 timings of 144, 103, and 109 ms TEs, tailored with simulation and phantom data, were tested in brain tumor patients in vivo. Lactate signals, broadened to singlet linewidths (similar to 6 Hz), were compared between simulation, phantom, and in vivo data. Results: Theoretical and experimental data indicated consistently that the MEGA-edited signal amplitude and width are sensitive to the E180 timings. In volume-localized MEGA, the lactate peak amplitudes in E180-on and difference spectra were maximized at specific E180 timings for individual TEs, largely due to the chemical-shift displacement effects. The E180 timings for maximum lactate peak amplitude were different from those of maximum inphase coherence in in vivo linewidth situations. Conclusion: In in vivo MEGA editing, the E180 pulse timings can be effectively used for manipulating the inphase and antiphase coherences and increasing the edited signal amplitude, following TE optimization. | Ganji, Sandeep K.; An, Zhongxu; Tiwari, Vivek; Chang, Yongmin; Patel, Toral R.; Maher, Elizabeth A.; Choi, Changho | Univ Texas Southwestern Med Ctr Dallas, Adv Imaging Res Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA; Univ Texas Southwestern Med Ctr Dallas, Dept Radiol, Dallas, TX 75390 USA; Philips Healthcare, Andover, MA USA; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu, South Korea; Univ Texas Southwestern Med Ctr Dallas, Dept Neurol Surg, Dallas, TX 75390 USA; Univ Texas Southwestern Med Ctr Dallas, Dept Neurol & Neurotherapeut, Dallas, TX 75390 USA; Univ Texas Southwestern Med Ctr Dallas, Dept Radiat Oncol, Dallas, TX 75390 USA; Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA; Univ Texas Southwestern Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA; Univ Texas Southwestern Med Ctr Dallas, Annette G Strauss Ctr Neurooncol, Dallas, TX 75390 USA | Ganji, Sandeep/G-4983-2013 | 14119653200; 55878195300; 55079170900; 7501840633; 36640783700; 7102985585; 55070978500 | Changho.Choi@UTSouthwestern.edu; | MAGNETIC RESONANCE IN MEDICINE | MAGN RESON MED | 0740-3194 | 1522-2594 | 87 | 3 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 3.3 | 35.2 | 0.42 | 2025-06-25 | 3 | 3 | H-1 MRS; 3T; editing 180 degrees RF pulse timings; J-difference editing (MEGA); lactate | MAGNETIC-RESONANCE-SPECTROSCOPY; HUMAN BRAIN; 2-HYDROXYGLUTARATE DETECTION; QUANTIFICATION; GLYCINE; GABA; PRODUCT; TUMORS; T-2; MRS | Heart Rate; Humans; Lactic Acid; Magnetic Resonance Spectroscopy; Phantoms, Imaging; Radio Waves; Chemical shift; Phantoms; Presses (machine tools); lactic acid; lactic acid; Antiphase; In-vivo; Localised; Low concentrations; Optimisations; Peak amplitude; Pulse timing; Radio frequency pulse; Signal amplitude; Single voxel; adult; Article; brain tumor; calculation; clinical article; controlled study; data analysis; female; human; in vivo study; proton nuclear magnetic resonance; radiofrequency; signal noise ratio; simulation; theoretical study; heart rate; imaging phantom; nuclear magnetic resonance spectroscopy; radiofrequency radiation; Metabolites | English | 2022 | 2022-03 | 10.1002/mrm.29051 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Chemical Bonding of Biomolecules to the Surface of Nano-Hydroxyapatite to Enhance Its Bioactivity | Hydroxyapatite (HA) is a significant constituent of bones or teeth and is widely used as an artificial bone graft. It is often used to replace the lost bones or in reconstructing alveolar bones before dental implantation. HA with biological functions finds its importance in orthopedic surgery and dentistry to increase the local concentration of calcium ions, which activate the growth and differentiation of mesenchymal stem cells (MSC). To make relevant use of HA in bone transplantation, the surfaces of orthopedic and dental implants are frequently coated with nanosized hydroxyapatite (nHA), but its low dispersibility and tendency to form aggregates, the purpose of the surface modification of bone implants is defeated. To overcome these drawbacks and to improve the histocompatibility of bone implants or to use nHA in therapeutic applications of implants in the treatment of bone diseases, various studies suggested the attachment of biomolecules (growth factors) or drugs through chemical bonding at the surface of nHA. The growth factors or drugs bonded physically at the surface of nHA are mostly unstable and burst released immediately. Therefore, reported studies suggested that the surface of nHA needs to be modified through the chemical bonding of biologically active molecules at the surface of bone implants such as proteins, peptides, or naturally occurring polysaccharides to prevent the aggregation of nHA and to get homogenous dispersion of nHA in solution. The role of irradiation in producing bioactive and antibacterial nHA through morphological variations in surfaces of nHA is also summarized by considering internal structures and the formation of reactive oxygen species on irradiation. This mini-review aims to highlight the importance of small molecules such as proteins, peptides, drugs, and photocatalysts in surface property modification of nHA to achieve stable, bioactive, and antibacterial nHA to act as artificial bone implants (scaffolds) in combination with biodegradable polymers. | Kang, Sohee; Haider, Adnan; Gupta, Kailash Chandra; Kim, Hun; Kang, Innkyu | Yeungnam Univ, Coll Med, Dept Dent, Daegu 42415, South Korea; Natl Univ Med Sci NUMS, Dept Biol Sci, Rawalpindi 46000, Pakistan; Indian Inst Technol, Dept Chem, Polymer Res Lab, Roorkee 247667, Uttar Pradesh, India; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea; Jeil Med Corp, Seoul 08378, South Korea | ; Gupta, Kailash/I-7478-2019 | 57874967700; 55506147800; 57198261272; 57196024332; 7203062733 | kangsh@yu.ac.kr;adnan_phd@outlook.com;kcgptfcy@iitr.ac.in;biohuny@jeilmed.co.kr;ikkang@knu.ac.kr; | COATINGS | COATINGS | 2079-6412 | 12 | 7 | SCIE | MATERIALS SCIENCE, COATINGS & FILMS;MATERIALS SCIENCE, MULTIDISCIPLINARY;PHYSICS, APPLIED | 2022 | 3.4 | 35.3 | 0.37 | 2025-06-25 | 15 | 16 | hydroxyapatite (HA); orthopedics; dentistry; chemical bonding; histocompatibility; therapeutic functions | BONE MORPHOGENETIC PROTEIN-2; IN-VITRO; COMPOSITE SCAFFOLDS; GROWTH-FACTORS; NANOCOMPOSITE SCAFFOLD; MECHANICAL-PROPERTIES; TISSUE REGENERATION; CALCIUM PHOSPHATES; ADSORPTION; IMPLANTS | chemical bonding; dentistry; histocompatibility; hydroxyapatite (HA); orthopedics; therapeutic functions | English | 2022 | 2022-07 | 10.3390/coatings12070999 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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