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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Effect of switching from nucleos(t)ide maintenance therapy to PegIFN alfa-2a in patients with HBeAg-positive chronic hepatitis B: A randomized trial | Aims Induction of a durable viral response is difficult to achieve in patients with chronic hepatitis B (CHB), even from long-term use of a nucleos(t)ide analogue (NA). This study investigated whether switching to peginterferon (PegIFN) alfa-2a after long-term NA therapy induced a durable viral response. Methods Patients with hepatitis B e antigen (HBeAg)-positive CHB who received any NA for at least 72 weeks and had a low level of HBV DNA (<= 100 IU/mL) were randomized (1:1) to receive PegIFN alfa-2a (180 mu g/week) or NA for 48 weeks. The primary endpoint was change in the hepatitis B surface antigen (HBsAg) titer during antiviral therapy. Results We randomized 149 CHB patients to the two groups. Compared to baseline, the HBsAg levels in both groups were not lower at week 12, but were lower after 24, 36, and 48 weeks (all p< 0.001). The maximal HBsAg decline in the PegIFN alfa-2a group was at week 36 (0.50 +/- 0.88 log(10) IU/mL), and this decline was smaller in the NA group (0.08 +/- 0.46 log(10) IU/mL). The percentage of patients with HBeAg seroconversion at week 48 was also greater in the PegIFN alfa-2a group (15/75 [20.0%] vs. 5/74 [6.8%], p = 0.018). Multivariable analysis indicated the PegIFN alfa-2a group had a greater change in HBeAg seroconversion at week 48 (p = 0.027). Patients had relatively good tolerance to PegIFN alfa-2a therapy. Conclusions CHB patients who switched to PegIFN alfa-2a for 48 weeks had a significantly lower HBsAg titer and increased HBeAg seroconversion relative to those who remained on NA therapy. | Woo, Hyun Young; Heo, Jeong; Tak, Won Young; Lee, Heon Ju; Chung, Woo Jin; Park, Jung Gil; Park, Soo Young; Park, Young Joo; Lee, Yu Rim; Hwang, Jae Seok; Kweon, Young Oh | Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Internal Med, Coll Med, Busan, South Korea; Pusan Natl Univ Hosp, Med Res Inst, Busan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Internal Med, Coll Med, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea | Park, Jung/AAK-5167-2020; Heo, Jeong/MHQ-1390-2025; Lee, Hyo-Suk/J-5618-2012 | 12787138800; 8422238800; 7004074582; 55085510500; 55741230500; 57216816399; 57191674344; 56697660800; 57194094753; 57205851488; 7004694832 | jheo@pusan.ac.kr;wytak@knu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.07 | 2025-06-25 | 1 | 1 | SURFACE-ANTIGEN; PEGINTERFERON ALPHA-2A; PEGYLATED INTERFERON-ALPHA-2B; HBSAG SEROCLEARANCE; ENTECAVIR TREATMENT; CLINICAL-OUTCOMES; ASIAN PATIENTS; VIRUS; LAMIVUDINE; COMBINATION | Antiviral Agents; DNA, Viral; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; adefovir; alanine aminotransferase; entecavir; hepatitis B(e) antigen; lamivudine; nucleoside analog; peginterferon alpha2a; tenofovir; antivirus agent; hepatitis B surface antigen; hepatitis B(e) antigen; macrogol; recombinant protein; virus DNA; acute gastroenteritis; adult; alanine aminotransferase blood level; alopecia; antibody titer; Article; body weight loss; chronic hepatitis B; chronic hepatitis C; clinical effectiveness; controlled study; depression; diabetes mellitus; drug fatality; drug substitution; drug tolerability; drug withdrawal; dyspepsia; dyspnea; ecchymosis; eczema; fatigue; female; flu like syndrome; gingiva pain; headache; human; hypertension; hypothyroidism; insomnia; intention to treat analysis; lung cancer; lung tuberculosis; maintenance therapy; major clinical study; male; myalgia; neutropenia; pneumonia; prospective study; pruritus; randomized controlled trial; seroconversion; serology; side effect; thorax pain; thrombocytopenia; treatment duration; treatment outcome; treatment response; treatment withdrawal; upper respiratory tract infection; visual impairment | English | 2022 | 2022-07-22 | 10.1371/journal.pone.0270716 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effects of focused ultrasound pulse duration on stimulating cortical and subcortical motor circuits in awake sheep | Low-intensity transcranial focused ultrasound (tFUS) offers new functional neuromodulation opportunities, enabling stimulation of cortical as well as deep brain areas with high spatial resolution. Brain stimulation of awake sheep, in the absence of the confounding effects of anesthesia on brain function, provides translational insight into potential human applications with safety information supplemented by histological analyses. We examined the effects of tFUS pulsing parameters, particularly regarding pulse durations (PDs), on stimulating the cortical motor area (M1) and its thalamic projection in unanesthetized, awake sheep (n = 8). A wearable tFUS headgear, custom-made for individual sheep, enabled experiments to be conducted without using anesthesia. FUS stimuli, each 200 ms long, were delivered to the M1 and the thalamus using three different PDs (0.5, 1, and 2 ms) with the pulse repetition frequency (PRF) adjusted to maintain a 70% duty cycle at a derated in situ spatial-peak temporal-average intensity (I-spta) of 3.6 W/cm(2). Efferent electromyography (EMG) responses to stimulation were quantified from both hind limbs. Group-averaged EMG responses from each of the hind limbs across the experimental conditions revealed selective responses from the hind limb contralateral to sonication. The use of 0.5 and 1 ms PDs generated higher EMG signal amplitudes compared to those obtained using a 2 ms PD. Faster efferent response was also observed from thalamic stimulation than that from stimulating the M1. Post-sonication behavioral observation and histological assessment performed 24 h and 1 month after sonication were not indicative of any abnormalities. The results suggest the presence of pulsing scheme-dependent effects of tFUS on brain stimulation and attest its safety in awake large animals. | Kim, Hyun-Chul; Lee, Wonhye; Kowsari, Kavin; Weisholtz, Daniel S.; Yoo, Seung-Schik | Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA; Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu, South Korea; MIT, Dept Mech Engn, Cambridge, MA 02139 USA; Harvard Med Sch, Brigham & Womens Hosp, Dept Neurol, Boston, MA USA | Lee, Wonhye/J-5166-2016; Kim, Leehyung/AAN-6760-2020 | 57194876917; 35755741800; 55943178100; 6505641180; 7401970708 | yoo@bwh.harvard.edu; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 12 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.5 | 2025-06-25 | 6 | 7 | BRAIN-STIMULATION; MAGNETIC-RESONANCE; NEUROMODULATION; CORTEX; MODULATION | Animals; Brain; Brain Mapping; Heart Rate; Humans; Motor Cortex; Sheep; Wakefulness; anesthesia; animal experiment; article; behavioral observation; brain depth stimulation; controlled study; electromyography; focused ultrasound therapy; hindlimb; histology; histopathology; human; nonhuman; primary motor cortex; sheep; thalamus; wakefulness; animal; brain; brain mapping; heart rate; motor cortex; physiology; procedures; sheep | English | 2022 | 2022-12-13 | 10.1371/journal.pone.0278865 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Electrically Small Circularly Polarized UWB Intraocular Antenna System for Retinal Prosthesis | Objective: This paper presents the design of an electrically small circularly polarized (CP) 3 x 3 mm(2) antenna system as an intraocular unit for retinal prosthesis application. Methods: The system is operating in ISM and ultra-wideband (UWB) bands to target high programmability of retina stimulation and recording, respectively. The electrical dimensions, including the ground plane, are lambda(0)/41 x lambda(0)/41 x lambda(0)/191. Physical limitations of the antenna are discussed based on Hansen and Collin's limitations. The proposed wire patch antenna exhibits wideband characteristics by combining multiple modes of the patch antenna in the presence of an interface PCB circuit. Results: By loading polyimide encapsulated patch with stubs, dominant TM010 mode is combined with the higher order modes TM020-TM070 to exhibit wide -10 dB impedance bandwidth of 2-11 GHz. Annular rings and shorting pins in the ground plane provide CP radiation at 2.45, 5.8, and 8 GHz with 3-dB axial-ratio bandwidth of 0.3, 0.16, and 1.2 GHz, and far-field left hand circularly polarized (LHCP) gain of -18.4, -7.6, and -4.7 dBic, respectively, in broadside direction. A biocompatible antenna system is designed using Ansys HFSS in the presence of a detailed multilayer canonical eye model. Additionally, it is examined in an anatomical HFSS head model. Near and far-field electric field distribution is studied along with peak 1-g average specific absorption rate (SAR) calculations. Conclusion: The proposed antenna is fabricated, and the performance, including coupled power from an external antenna, is measured in a custom made eye model including head phantom. A reasonable agreement is obtained between simulated and measured results. Significance: To generate an artificial vision, image perception capability could be improved with implantable UWB communication systems that feature particularly high data-rate and small size. | Kaim, Vikrant; Kanaujia, Binod Kumar; Kumar, Sachin; Choi, Hyun Chul; Kim, Kang Wook; Rambabu, Karumudi | Jawaharlal Nehru Univ, Sch Computat & Integrat Sci, New Delhi, India; Dr BR Ambedkar Natl Inst Technol, Jalandhar, Punjab, India; SRM Inst Sci & Technol, Dept Elect & Commun Engn, Chennai, Tamil Nadu, India; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Univ Alberta, Dept Elect & Comp Engn, Edmonton, AB, Canada | ; Kanaujia, Binod/L-6484-2019; kanaujia, Binod/L-6484-2019; Kumar, Sachin/W-2211-2019 | 57204075245; 56962785800; 56907994000; 57193342681; 57204432422; 24171880600 | kang_kim@ee.knu.ac.kr; | IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | IEEE T BIO-MED ENG | 0018-9294 | 1558-2531 | 69 | 11 | SCIE | ENGINEERING, BIOMEDICAL | 2022 | 4.6 | 34.9 | 1.53 | 2025-06-25 | 13 | 19 | Canonical eye model; circularly polarized; coupled power; electrically small; intraocular antenna; mode analysis; radiating field; retinal prosthesis; ultrawideband | IMPLANTABLE ANTENNA; TELEMETRY LINK; HUMAN EYE; DESIGN; RADIATION; LIMITATIONS; BODY | Canonical eye model; circularly polarized; coupled power; electrically small; intraocular antenna; mode analysis; radiating field; retinal prosthesis; ultra-wideband | Electric Impedance; Equipment Design; Visual Prosthesis; Wireless Technology; Biocompatibility; Circular polarization; Dipole antennas; Electric fields; Electric impedance; Image enhancement; Microstrip antennas; Microwave antennas; Ophthalmology; Slot antennas; Ultra-wideband (UWB); polyimide; Antennas measurement; Canonical eye model; Circularly-polarized; Coupled power; Electrically small; Eye model; Intraocular; Intraocular antenna; Mode analysis; Radiating field; Retina; Retinal prosthesis; Ultra wideband antenna; Ultrawide band; Wideband antenna; Article; bandwidth; calculation; circularly polarized luminescence; dipole; electric field; equipment design; impedance; light harvesting system; simulation; visual prosthesis; wireless communication; Bandwidth | English | 2022 | 2022-11 | 10.1109/tbme.2022.3171842 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Evolution of Mesenchymal Stem Cell Therapy as an Advanced Therapeutic Medicinal Product (ATMP)-An Indian Perspective | Stem cells can be defined as the cells that have the capacity to both self-renew and give rise to differentiated cells. Under the right conditions and signals, depending on their origin and bio-plasticity, stem cells can differentiate into multiple cell lineages and develop into various mature cells. Stem cell therapy is a fast-developing branch of medicine that includes the most innovative regenerative therapies for the restoration of cell and tissue function in individuals with severe diseases. Stem cell research has resulted in the emergence of cell-based therapies for disorders that are resistant to conventional drugs and therapies, and they are considered under the category of an Advanced Therapeutic Medicinal Product (ATMP). The FDA and the European Medicines Agency (EMA) devised a new strategy in 2017 with the aim of unifying the standards for development of ATMPs such that it is easy to exchange information at the international level. In this review, we discuss the evolution of mesenchymal stem cell-based therapy as an ATMP in the global and Indian scenarios, along with the guidelines governing their usage and clinical application of these therapeutics. | Muthu, Sathish; Jeyaraman, Madhan; Kotner, Moinuddin Basha; Jeyaraman, Naveen; Rajendran, Ramya Lakshmi; Sharma, Shilpa; Khanna, Manish; Rajendran, Sree Naga Sowndary; Oh, Ji Min; Gangadaran, Prakash; Ahn, Byeong-Cheol | Govt Med Coll & Hosp, Dept Orthopaed, Dindigul 624001, India; Indian Stem Cell Study Grp, Lucknow 226010, Uttar Pradesh, India; Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, India; Dr MGR Educ & Res Inst Univ, Fac Med, Dept Orthopaed, Sri Lalithambigai Med Coll & Hosp, Chennai 600095, Tamil Nadu, India; Dr Ram Manohar Lohiya Natl Law Univ, Orthopaed Rheumatol, Lucknow 226012, Uttar Pradesh, India; Tamil Nadu Dr MGR Med Univ, Atlas Hosp, Joint Replacement, Tiruchirappalli 620002, India; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; All India Inst Med Sci, Dept Paediat Surg, New Delhi 110029, India; Sri Venkateshwaraa Med Coll Hosp & Res Ctr, Dept Med, Pondicherry 605107, India; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea | Rajendran, Ramya/AAV-6338-2021; Sharma, Shilpa/T-6420-2019; Muthu, Sathish/G-5756-2018; Gangadaran, Prakash/AAV-3102-2021; Jeyaraman, Madhan/ABB-8464-2020 | 57217850874; 57216926503; 57536828800; 57219306833; 57195318729; 55491666000; 57220576074; 57432957800; 57190370462; 54393130400; 7202791511 | drsathishmuthu@gmail.com;madhanjeyaraman@gmail.com;moin1503@gmail.com;naveenjeyaraman@yahoo.com;ramyag@knu.ac.kr;drshilpas@gmail.com;manishvenus@rediffmail.com;sowndaryasreeraj8@gmail.com;ojm0366@knu.ac.kr;prakashg@knu.ac.kr;abc2000@knu.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 9 | 3 | SCIE | ENGINEERING, BIOMEDICAL | 2022 | 4.6 | 34.9 | 0.54 | 2025-06-25 | 16 | 17 | ATMP; India; stem cell; mesenchymal stem cell; regulations | ATMP; India; Mesenchymal stem cell; Regulations; Stem cell | English | 2022 | 2022-03 | 10.3390/bioengineering9030111 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Factors affecting household disaster preparedness in South Korea | This study examines current household disaster preparedness and identifies its predictors in South Korea. A structured online survey was administered to 1,243 participants quota-sampled by age and population from each administrative district. Based on the socio-ecological model, interpersonal factors (general characteristics, prior disaster experience, anxiety, dispositional optimism, perceived disaster risk, and disaster preparedness knowledge), institutional factor (front-line preparedness), community factor (community resilience), public policy factor (governmental preparedness), and household disaster preparedness were measured. The data were analyzed using descriptive statistics, Mann-Whitney U test, Kruskal-Wallis test, Bonferroni test, Pearson's correlation coefficients, and multiple regression. The predictors of household disaster preparedness were occupation, economic status, prior disaster experience, anxiety, disaster preparedness knowledge, front-line preparedness, and community resilience. The most potent predictor of household disaster preparedness was community resilience. Our finding that community resilience, a community factor, has a greater impact on household disaster preparedness than personal factors calls for programs that promote such resilience. Further, continuous public education and campaigns are needed to increase public awareness of household disaster preparedness and to improve the public's competency to prepare for potential disasters. This study raises the need for community programs for residents to increase household disaster preparedness knowledge and improve their competencies related to disaster response. This study is significant in highlighting the importance of community factors in improving household disaster preparedness amid the need to prepare for various types of disasters. | Kim, Yujeong; Kim, Mi Young | Kyungpook Natl Univ, Res Inst Nursing Sci, Coll Nursing, Daegu, South Korea; Hanyang Univ, Coll Nursing, Seoul, South Korea | 57200941945; 57069194800 | miyoung0@hanyang.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 10 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 1.28 | 2025-06-25 | 16 | 19 | EMERGENCY PREPAREDNESS; ANXIETY | Disaster Planning; Disasters; Family Characteristics; Humans; Republic of Korea; Socioeconomic Factors; Surveys and Questionnaires; adult; anxiety; article; awareness; community program; community resilience; controlled study; correlation coefficient; disaster; disaster preparedness; disaster response; economic status; education; female; household; human; human tissue; Kruskal Wallis test; major clinical study; male; multiple regression; occupation; optimism; public policy; rank sum test; resident; South Korea; disaster; disaster planning; family size; questionnaire; socioeconomics; South Korea | English | 2022 | 2022-10-04 | 10.1371/journal.pone.0275540 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Foreign-body aspiration into the lower airways in adults; multicenter study | BackgroundForeign-body aspiration is common in children aged 6 months to 3 years. However, with the aging population and increasing prevalence of disabilities such as hemiparesis and neuromuscular diseases in adults, an increased incidence of aspiration is expected. MethodsThis was a multicenter retrospective, observational study in four major referral hospitals in Daegu, South Korea, between 2000 and 2019. We included patients aged over 18 years who were evaluated for tracheobronchial foreign-body aspiration by flexible bronchoscopy. Comorbidities, type and location of foreign body, and radiologic findings were recorded. ResultsOf 138 patients who underwent flexible bronchoscopy for tracheobronchial foreign body aspiration, 91 (65.9%) were men; the mean age was 66.3 (range: 29-87) years. A history of definite choking was present in 60 (43.5%) patients. The most common site of the foreign body was the right bronchus intermedius (27.5%). The most common type of aspirated foreign body was teeth (37.7%), followed by chicken bone (15.2%), nuts (14.5%) and fish bone (9.4%). Iatrogenic events accounted for 37.0% of the cases of aspiration, and the foreign body was successfully removed by flexible bronchoscopy in 91.3% of cases. ConclusionForeign-body aspiration is not rare, even in adults who do not have predisposing factors. Iatrogenic events accounted for about 40% of all cases of foreign body aspiration. In adults, flexible bronchoscopy is relatively safe and has a high success rate for foreign-body removal. | Jang, Gimun; Song, Jae Woon; Kim, Hyun Jung; Kim, Eun Jin; Jang, Jong Geol; Cha, Seung-Ick | Keimyung Univ, Sch Med, Dept Med, Daegu, South Korea; Keimyung Univ Dongsan Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yeungnam Univ Hosp, Reg Resp Ctr, Dept Internal Med, Div Pulm & Crit Care Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Pulm & Crit Care Med, Daegu, South Korea | Kim, Eun/AAS-6706-2020; Hyun-Jung, Kim/E-8074-2011; Kim, Eun Jin/L-6480-2018 | 57789257000; 57788611600; 57196215317; 55927957400; 56645456400; 35227126400 | khj82827@kmu.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 7 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.92 | 2025-06-25 | 15 | 13 | DENTAL PRACTICE; BODIES; MANAGEMENT; CHILDREN; EXPERIENCE; INGESTION | Adult; Aged; Bronchoscopy; Foreign Bodies; Humans; Iatrogenic Disease; Middle Aged; Prevalence; Retrospective Studies; adult; age distribution; aged; airway obstruction; Article; bone; bronchoscopy; bronchus; bronchus intermedius; chicken; clinical feature; comorbidity; computer assisted tomography; controlled study; female; fish; food; foreign body aspiration; hospital; human; lower respiratory tract; major clinical study; male; medical history; multicenter study; nut; observational study; patient referral; pill; retrospective study; risk factor; South Korea; thorax radiography; tooth; tracheobronchial foreign body aspiration; very elderly; adverse event; bronchoscopy; clinical trial; foreign body; iatrogenic disease; middle aged; prevalence | English | 2022 | 2022 | 10.1371/journal.pone.0269493 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | From crop specific to variety specific in crop modeling for the smart farm: A case study with blueberry | Facility cultivation has been evolved from greenhouses to smart farms using artificial intelligence (AI) that simulates big data to maximize production. However, the big data for AI in smart farm is not studied well; the effect of differences among varieties within a crop remains unclear. Therefore, the response of two varieties of blueberry, 'Suziblue' and 'Star', to light was tested using SAPD meter in order to demonstrate the environmental responses could be different among varieties within the same species. The results showed that those two varieties had significant differences in SPAD values based on the leaf's position and time, whereas 'Star' did not. This indicates that the effect of light depends on the variety, which implies that other traits and other crops may show similar differences. These results are based on a simple experiment. However, it is enough to elucidate that it is extremely important to characterize responses to the environment not only for each crop but also for each variety to collect data for smart farming to increase accuracy for modeling; consequently, to maximize the efficiency of these facilities. | Han, Gyung Deok; Choi, Jeong Min; Choi, Inchan; Kim, Yoonha; Heo, Seong; Chung, Yong Suk | Cheongju Natl Univ Educ, Dept Pract Course Educ, Cheongju, South Korea; Natl Inst Agr Sci, Dept Agr Engn, Jeonju, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Kongju Natl Univ, Dept Hort, Yesan, South Korea | ; Chung, Yong/V-6909-2019 | 57191094095; 57870740900; 57209627559; 57224866763; 35898345700; 36983850100 | heoseong@konju.ac.kr;yschung@jejunu.ac.kr;heoseong@kongju.ac.kr; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 8 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.5 | 2025-06-25 | 6 | 7 | GROWTH | Agriculture; Artificial Intelligence; Blueberry Plants; Crops, Agricultural; Farms; agricultural worker; article; blueberry; crop; human; nonhuman; plant leaf; agricultural land; agriculture; artificial intelligence; crop; procedures | English | 2022 | 2022-08-30 | 10.1371/journal.pone.0273845 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Household decision-making and the mental well-being of marriage-based immigrant women in South Korea | Objective We assessed the association between household decision-making and mental well-being among Asian immigrant women residing in Korea. We also investigated if the impact varies by the regional origin and examined potential factors for joint decision-making. Methods We conducted a cross-sectional study using the Korean National Survey of Multicultural Families 2015 and logistic regression. We analyzed data from 11,188 married immigrant women ages 20 to 59 who were originally from East Asia or Southeast/South Asia and coliving with their spouses. We defined households as joint-decision, wife-decision, or husband- decision based on who decides how living expenses are spent. Mental well-being encompassed a depressive mood for two consecutive weeks, and life and marital satisfaction. Results After controlling for covariates, we showed that immigrant women in husband-decision households were more likely to have depressive mood (odds ratio [OR] 1.26, 95% confidence interval [CI]: 1.14-1.38), poorer life satisfaction (OR 1.49, 95% CI: 1.24-1.78), and poorer marital satisfaction (OR 1.81, 95% CI: 1.47-2.22) than women in joint-decision households. Immigrant women in wife-decision households had a similar but slightly lower odds of poor mental well-being. This association was less prominent for Southeast/South Asian origin than East Asian origin, while the age-adjusted prevalence rates of poor mental well-being among them were higher than their East Asian counterparts. Factors that restricted the odds of husband-decision did not necessarily guarantee wife-decision. Conclusions This study suggests one-sided decision-making can be a risk factor for immigrant women's poor mental well-being, while joint decision-making is protective. Differences across regional origins suggest domestic decision-making might be a less important predictor for mental well-being in immigrants more occupied with adapting to the host society. Factors for joint decision-making should be addressed to improve the mental well-being of immigrant women. © 2022 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Lee, Eunji; Kim, Soo In; Jung-Choi, Kyunghee; Kong, Kyoung Ae | Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea, Kyungpook National University Law School, Daegu, South Korea; Department of Psychiatry, College of Medicine, Ewha Womans University, Seoul, South Korea; Department of Occupational and Environmental Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea; Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea | 57464855600; 54787809400; 23477807800; 8622974400 | kkong@ewha.ac.kr; | PLoS ONE | PLOS ONE | 1932-6203 | 1932-6203 | 17 | 2 February | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.14 | 2025-06-25 | 2 | Adult; Asia, Southeastern; Asians; Cross-Sectional Studies; Decision Making; Emigrants and Immigrants; Family Characteristics; Female; Humans; Mental Health; Middle Aged; Republic of Korea; Risk Factors; Spouses; adult; age distribution; Article; Asia; Asian; cohabitation; controlled study; cross-sectional study; cultural diversity; decision making; depression; East Asia; female; geographic origin; health survey; household decision making; human; husband decision making; immigrant; joint decision making; life satisfaction; major clinical study; male; marriage; prevalence; protection; psychological well-being; risk factor; South Asia; South Korea; Southeast Asia; spouse; wife decision making; ethnology; family size; mental health; middle aged; migrant; psychology | English | Final | 2022 | 10.1371/journal.pone.0263642 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | How Does the Use of an Intraoral Scanner Affect Muscle Fatigue? A Preliminary In Vivo Study | The purpose of this study was to evaluate muscle activation and fatigue in the operator during tooth preparation and intraoral scanning by simulating these tasks in two types of dental unit chair systems (UCS). Six participants were recruited, and the above tasks were simulated. Electrodes were placed on the skin over five types of muscles (arm, neck, and shoulder muscles), and the maximal voluntary contraction (MVC) was measured. Electromyography (EMG) was assessed during the simulation, and EMG values were normalized using MVC. The root mean square (RMS) EMG (%MVC) and muscle fatigue (%) were calculated. Owing to a lack of normal distribution of the data, Mann-Whitney U test and Kruskal-Wallis H test were performed for statistical comparison, and Bonferroni adjustment was performed for multiple comparisons (alpha = 0.05). There was no significant difference in RMS EMG between the two types of dental UCS (intraoral scanning, p = 0.237; tooth preparation, p = 0.543). Moreover, the RMS EMG and muscle fatigue were not significantly different between the two tasks (p > 0.05). There was significant muscle fatigue after the intraoral scanner use was simulated thrice (p < 0.001). It is necessary to refrain from performing continuous intraoral scanning and tooth preparation and to take appropriate rest to reduce the incidence of musculoskeletal disorders in dentists in clinical settings. | Son, KeunBaDa; Lee, Ji-Min; Son, Young-Tak; Kim, Jin-Wook; Jin, Myoung-Uk; Lee, Kyu-Bok | Kyungpook Natl Univ, Adv Dent Device Dev Inst A3DI, Daegu 41940, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Conservat Dent, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Maxillofacial Surg, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu 41940, South Korea | Lee, Ji Min/KCZ-2783-2024; SON, Keunbada/AAG-8089-2019; Son, Keunbada/AAG-8089-2019 | 57202916520; 57193811541; 57219111205; 55862646000; 56492091300; 15925571200 | oceanson@knu.ac.kr;wlals9408@naver.com;dudxkr741@naver.com;vocaleo@naver.com;musljin@knu.ac.kr;kblee@knu.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 9 | 8 | SCIE | ENGINEERING, BIOMEDICAL | 2022 | 4.6 | 34.9 | 0.53 | 2025-06-25 | 8 | 7 | dentistry; dental unit chair systems; muscle fatigue; muscle activation; in vivo study | dental unit chair systems; dentistry; in vivo study; muscle activation; muscle fatigue | English | 2022 | 2022-08 | 10.3390/bioengineering9080358 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Impact of the Process Variables on the Yield of Mesenchymal Stromal Cells from Bone Marrow Aspirate Concentrate | Human bone marrow (BM) has been highlighted as a promising source of mesenchymal stromal cells (MSCs) containing various growth factors and cytokines that can be potentially utilized in regenerative procedures involving cartilage and bone. However, the proportion of MSCs in the nucleated cell population of BM is only around 0.001% to 0.01% thereby making the harvesting and processing technique crucial for obtaining optimal results upon its use in various regenerative processes. Although several studies in the literature have given encouraging results on the utility of BM aspiration concentrate (BMAC) in various regenerative procedures, there is a lack of consensus concerning the harvesting variables such as choice of anesthetic agent to be used, site of harvest, size of the syringe to be used, anticoagulant of choice, and processing variables such as centrifugation time, and speed. In this review article, we aim to discuss the variables in the harvesting and processing technique of BMAC and their impact on the yield of MSCs in the final concentrate obtained from them. | Jeyaraman, Madhan; Bingi, Shiva Kumar; Muthu, Sathish; Jeyaraman, Naveen; Packkyarathinam, Rathinavelpandian Perunchezhian; Ranjan, Rajni; Sharma, Shilpa; Jha, Saurabh Kumar; Khanna, Manish; Rajendran, Sree Naga Sowndary; Rajendran, Ramya Lakshmi; Gangadaran, Prakash | Sri Lalithambigai Med Coll & Hosp, Dr MGR Educ & Res Inst, Fac Med, Dept Orthopaed, Chennai 600095, Tamil Nadu, India; Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida 201310, India; Indian Stem Cell Study Grp ISCSG Assoc, Lucknow 226010, Uttar Pradesh, India; Dr RML Natl Law Univ, Orthopaed Rheumatol, Lucknow 226010, Uttar Pradesh, India; Govt Med Coll & Hosp, Dept Orthopaed, Dindigul 624304, India; Atlas Hosp, Dept Orthopaed, Joint Replacement, Tiruchirappalli 620002, India; Govt Med Coll, Dept Orthopaed, Omandurar Govt Estate, Chennai 600002, Tamil Nadu, India; Sharda Univ, Sch Med Sci & Res, Dept Orthopaed, Greater Noida 201310, India; All India Inst Med Sci, Dept Paediat Surg, New Delhi 110029, India; Prasad Inst Med Sci, Dept Orthopaed, Lucknow 226401, Uttar Pradesh, India; Sri Venkateshwaraa Med Coll Hosp & Res Ctr, Dept Med, Pondicherry 605102, India; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu 41944, South Korea | ; Muthu, Sathish/G-5756-2018; Sharma, Shilpa/T-6420-2019; Jeyaraman, Madhan/ABB-8464-2020; Rajendran, Ramya/AAV-6338-2021; R P, PACKKYA RATHINAM/KSL-7197-2024; Jha, Dr. Saurabh/ACC-9874-2022; Gangadaran, Prakash/AAV-3102-2021 | 57216926503; 57431168200; 57217850874; 57219306833; 57386300900; 56661828600; 55491666000; 56425051500; 57220576074; 57432957800; 57195318729; 54393130400 | madhanjeyaraman@gmail.com;skumarbingi65@gmail.com;drsathishmuthu@gmail.com;naveenjeyaraman@yahoo.com;packkyarathinam@gmail.com;orthoranjan04@gmail.com;drshilpas@gmail.com;saurabh.jha@sharda.ac.in;manishvenus@rediffmail.com;sowndaryasreeraj8@gmail.com;ramyag@knu.ac.kr;prakashg@knu.ac.kr; | BIOENGINEERING-BASEL | BIOENGINEERING-BASEL | 2306-5354 | 9 | 2 | SCIE | ENGINEERING, BIOMEDICAL | 2022 | 4.6 | 34.9 | 0.64 | 2025-06-25 | 16 | 19 | bone marrow; bone marrow aspirate concentrate; mesenchymal stromal cells | Bone marrow; Bone marrow aspirate concentrate; Mesenchymal stromal cells | English | 2022 | 2022-02 | 10.3390/bioengineering9020057 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Incidence of hypothyroidism after treatment for breast cancer: A Korean population-based study | This Korean population-based study aimed to describe the patterns of hypothyroidism after adjuvant radiation therapy (RT) in patients with breast cancer. The Korean Health Insurance Review and Assessment Service database was searched for patients with invasive breast carcinomas. We calculated the cumulative incidence and incidence rates per 1,000 person-years of subsequent hypothyroidism and compared them using the log-rank test and the Cox proportional hazards model. Between 2007 and 2018, 117,135 women diagnosed with breast cancer with a median follow-up time of 4.6 years were identified. The 8-year incidence of hypothyroidism was 9.3% in patients treated with radiation and 8.6% in those treated without radiation (p = 0.002). The incidence rates per 1,000 person-years in the corresponding treatment groups were 6.2 and 5.7 cases, respectively. The hazard ratio (HR) in patients receiving RT was 1.081 (95% confidence interval [CI], 1.013-1.134; p = 0.002). After mastectomy, RT showed a trend toward a higher risk of hypothyroidism (HR = 1.248; 95% CI, 0.977-1.595; p = 0.076). Our study provides one of the largest population-based data analyses regarding the risk of hypothyroidism among Korean patients with breast cancer. The adjusted risk for patients treated with RT exceeded that for patients with breast cancer treated without RT. The effect was evident immediately after treatment and lasted up to approximately 9 years. | Park, Jongmoo; Kim, Choongrak; Ki, Yongkan; Kim, Wontaek; Nam, Jiho; Kim, Donghyun; Park, Dahl; Jeon, Hosang; Kim, Dong Woon; Joo, Ji Hyeon | Kyungpook Natl Univ, Sch Med, Dept Radiat Oncol, Daegu, South Korea; Pusan Natl Univ, Dept Stat, Busan, South Korea; Pusan Natl Univ, Dept Radiat Oncol, Sch Med, Yangsan, South Korea; Pusan Natl Univ, Dept Radiat Oncol, Yangsan Hosp, Yangsan, South Korea; Pusan Natl Univ Hosp, Dept Radiat Oncol, Busan, South Korea | Kim, Donghyun/HDO-8306-2022 | 56180048900; 8385732600; 35088292300; 57212278371; 55647552100; 55574225162; 55248877600; 36705891700; 59543300600; 55888566300 | hi_juji@daum.net; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 6 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.43 | 2025-06-25 | 4 | 6 | RADIATION-INDUCED HYPOTHYROIDISM; RADIOTHERAPY; IRRADIATION; HEAD; DISEASE; HEALTH; COHORT; RISK | Breast Neoplasms; Female; Humans; Hypothyroidism; Incidence; Mastectomy; Proportional Hazards Models; Radiotherapy, Adjuvant; Republic of Korea; adult; aged; Article; breast cancer; cancer patient; cancer radiotherapy; cancer surgery; comparative study; controlled study; cumulative incidence; data analysis; female; human; hypothyroidism; Korean (people); major clinical study; mastectomy; middle aged; risk assessment; adjuvant radiotherapy; adverse event; breast tumor; hypothyroidism; incidence; proportional hazards model; South Korea | English | 2022 | 2022 | 10.1371/journal.pone.0269893 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Non-occlusive mesenteric ischemia in critically ill patients | Background Non-occlusive mesenteric ischemia (NOMI) is a life-threatening acute condition that has an overall in-hospital mortality rate of up to 75%. Critically ill patients are often admitted to intensive care units (ICUs) due to shock, and these patients are frequently at risk of developing NOMI. The objective of this study was to determine the clinical features of critically ill patients with NOMI and evaluate the risk factors for in-hospital mortality among these patients. Methods We reviewed the electronic medical records of 7,346 patients who underwent abdominal contrast-enhanced computed tomography during their ICU stay at Samsung Medical Center (Seoul, Korea) between January 1, 2010 and December 31, 2019. After reviewing each patient's computed tomography (CT) scans, 60 patients were diagnosed with NOMI and included in this analysis. The patients were divided into survivor (n = 23) and non-survivor (n = 37) groups according to the in-hospital mortality. Results The overall sequential organ failure assessment (SOFA) score for the included patients upon admission to the ICU was 8.6 3.1, and medical ICU admissions were most common (66.7%) among the patients. The SOFA score upon admission to the ICU was higher for the non-survivors than for the survivors (9.4 vs. 7.4; p = 0.017). Non-survivors were more often observed in the medical ICU admissions (39.1% vs. 83.8%) than in the surgical ICU admissions (47.8% vs. 10.8%) or the cardiac ICU admissions (13.0% vs. 5.4%). Laboratory test results, abdominal CT findings, and the use of vasopressors and inotropes did not differ between the two groups. In a multivariable analysis, SOFA scores >8 upon admission to the ICU (odds ratio [OR] 4.51; 95% 1.12-18.13; p = 0.034), patients admitted to the ICU with medical problems (OR 7.99; 95% 1.73-36.94; p = 0.008), and abdominal pain (OR 4.26; 95% 1.05-17.35; p = 0.043) were significant prognostic predictors for in-hospital mortality. Conclusions The SOFA score >8 upon admission to the ICU, admission to the ICU for medical problems, and abdominal pain at diagnosis are associated with increased mortality among patients with NOMI. | Yu, Byunghyuk; Ko, Ryoung-Eun; Yoo, Keesang; Gil, Eunmi; Choi, Kyoung-Jin; Park, Chi-Min | Sungkyunkwan Univ, Samsung Med Ctr, Dept Crit Care Med, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Intens Care Unit, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Surg, Sch Med, Seoul, South Korea | ; Yu, Byunghyuk/HGB-0950-2022 | 57208745241; 57200827816; 57211157425; 55389337900; 57192301562; 25522412200 | kjkj.choi@samsung.com;dr99.park@samsung.com; | PLOS ONE | PLOS ONE | 1932-6203 | 17 | 12 | SCIE | MULTIDISCIPLINARY SCIENCES | 2022 | 3.7 | 34.9 | 0.92 | 2025-06-25 | 13 | 13 | VASOPRESSOR; SCORE | Critical Illness; Hospital Mortality; Hospitalization; Humans; Intensive Care Units; Mesenteric Ischemia; Organ Dysfunction Scores; Prognosis; Retrospective Studies; abdominal pain; adult; Article; clinical feature; cohort analysis; computer assisted tomography; contrast enhancement; critically ill patient; female; hospital admission; human; in-hospital mortality; intensive care unit; major clinical study; male; mesenteric ischemia; retrospective study; risk factor; Sequential Organ Failure Assessment Score; critical illness; hospital mortality; hospitalization; organ dysfunction score; prognosis | English | 2022 | 2022-12-19 | 10.1371/journal.pone.0279196 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Overexpression of C-Repeat Binding Factor1 (CBF1) Gene Enhances Heat Stress Tolerance in Arabidopsis | High temperature affects plant growth, development, and seed production. We generated Arabidopsis transgenic plants overexpressing abiotic stress-tolerance associated genes (CBF1, GolS1, NDPK2, YUC6, and PRE1) to investigate the effects of these genes on heat stress (HS) tolerance. We evaluated thermotolerance by assessing the survival rate of T-2 seedlings under acute HS conditions. C-repeat binding factor 1-overexpressing (CBF1-OE) plants exhibited drastically improved HS tolerance, whereas overexpression of the other examined genes yielded marginal effects. Consistent with the ability of CBF1 to regulate transcription, we found that the transcription of several heat-shock inducible genes was remarkably increased in CBF1-OE plants under HS conditions. Furthermore, the expression of several reactive oxygen species (ROS)-responsive genes related to oxidative stress was notably upregulated in CBF1-OE plants. Thus, the thermotolerance of CBF1-OE plants is at least partly associated with the elevated expression of several HS-inducible and ROS-responsive genes. Our study showed that CBF1 plays a role in increasing HS tolerance in Arabidopsis in addition to its previously established roles in cold/drought tolerance. | Yun, Sang Dae; Kim, Myung-Hee; Oh, Sung Aeong; Soh, Moon-Soo; Park, Soon Ki | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Sejong Univ, Coll Life Sci, Div Integrat Biosci & Biotechnol, Seoul 05006, South Korea | 57210883667; 57221718078; 7404104444; 7004615614; 8055974900 | psk@knu.ac.kr; | JOURNAL OF PLANT BIOLOGY | J PLANT BIOL | 1226-9239 | 1867-0725 | 65 | 3 | SCIE | PLANT SCIENCES | 2022 | 2.9 | 34.9 | 0.67 | 2025-06-25 | 7 | 6 | CBF1; Heat tolerance; Heat stress; Heat shock protein; ROS | CYTOSOLIC ASCORBATE PEROXIDASE; TRANSCRIPTION FACTOR DREB2A; LOW-TEMPERATURE; FUNCTIONAL-ANALYSIS; FACTOR HSFA3; SHOCK; EXPRESSION; PLANTS; THERMOTOLERANCE; ACCLIMATION | CBF1; Heat shock protein; Heat stress; Heat tolerance; ROS | English | 2022 | 2022-06 | 10.1007/s12374-022-09350-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Overexpression of TWO-IN-ONE Domains Inhibits Cytokinesis in Arabidopsis | Plant cells undergoing cytokinesis build a cell plate between daughter nuclei and expand it centrifugally toward the parental plasma membrane. This process is enabled by the phragmoplast, a plant-specific and highly dynamic microtubule (MT)-based array. A signaling module required for phragmoplast expansion consisting of TWO-IN-ONE (TIO) and two Kinesin-12 members is described in Arabidopsis thaliana. TIO is a deeply conserved Fused kinase that has a divergent plant-specific role in cytokinesis. TIO has two conserved domains, the N-terminal kinase and the C-terminal ARM/HEAT domains, which are crucial for function and interaction with the phragmoplast MT plus-end associated Kinesin-12A and -12B. Here, we further explored the importance of TIO domains for cytokinesis in an overexpression approach. In addition, the functionality of a putative activation loop in the kinase domain was validated by substituting two invariant threonine and serine residues. Phenotypic analysis reveals that overexpression of the domains severely interferes with cytokinesis in pollen and in somatic cells. Furthermore, measuring the level of rescue for gametophytic cytokinesis in tio-3 null mutant background reveals that the putative kinase activation loop is required for TIO function and likely operates via reversible phosphorylations. Therefore, this study enhances understanding of TIO signaling and domain functions in cytokinesis. | Oh, Sung-Aeong; Lee, Sang Ju; Kim, Jeong Hoe; Twell, David; Park, Soon Ki | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Biol, Daegu 41566, South Korea; Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England | Kim, So-Young/JFS-7698-2023; Twell, David/D-8043-2011 | 7404104444; 57709645100; 7601377826; 7004821730; 8055974900 | psk@knu.ac.kr; | JOURNAL OF PLANT BIOLOGY | J PLANT BIOL | 1226-9239 | 1867-0725 | 65 | 4 | SCIE | PLANT SCIENCES | 2022 | 2.9 | 34.9 | 0 | 2025-06-25 | 0 | 0 | Arabidopsis; Cytokinesis; Domain overexpression; Male meiosis; Pollen mitosis I; TWO-IN-ONE | MICROTUBULE-ASSOCIATED PROTEIN; KINASE KINASE KINASE; MALE MEIOTIC CYTOKINESIS; FUSED KINASE; CELL-PLATE; ANTIPARALLEL MICROTUBULES; GENE ENCODES; KINESIN; PHRAGMOPLAST; PHOSPHORYLATION | Arabidopsis; Cytokinesis; Domain overexpression; Male meiosis; Pollen mitosis I; TWO-IN-ONE | English | 2022 | 2022-08 | 10.1007/s12374-022-09353-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis | BACKGROUNDFexuprazan, a novel potassium-competitive acid blocker, reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal cells. Fexuprazan's suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent manner.AIMTo compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis (EE).METHODSKorean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight weeks. The primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week 8. The secondary endpoints included the healing rate of EE at week 4, symptom response, and quality of life assessment. Safety profiles and serum gastrin levels were compared between the groups.RESULTSOf the 263 randomized, 218 completed the study per protocol (fexuprazan 40 mg, n = 107; esomeprazole 40 mg, n = 111). Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8 [99.1% (106/107) vs 99.1% (110/111)]. There were no between-group differences in the EE healing rate at week 4 [90.3% (93/103) vs 88.5% (92/104)], symptom responses, and quality of life assessments. Additionally, serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the groups.CONCLUSIONFexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week 8. We suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE. | Lee, Kang Nyeong; Lee, Oh Young; Chun, Hoon Jai; Kim, Jin Il; Kim, Sung Kook; Lee, Sang Woo; Park, Kyung Sik; Lee, Kook Lae; Choi, Suck Chei; Jang, Jae-Young; Ha Kim, Gwang; Sung, In-kyung; Park, Moo In; Kwon, Joong Goo; Kim, Nayoung; Kim, Jae Jun; Lee, Soo Teik; Kim, Hyun Soo; Kim, Ki Bae; Lee, Yong Chan; Choi, Myung-Gyu; Lee, Joon Seong; Jung, Hwoon-Yong; Lee, Kwang Jae; Kim, Jie-Hyun; Chung, Hyunsoo | Hanyang Univ, Dept Internal Med, Coll Med, 222 Wangsimni Ro, Seoul 04763, South Korea; Korea Univ, Dept Internal Med, Anam Hosp, Seoul 02841, South Korea; Catholic Univ Korea, Yeouido ST Marys Hosp, Dept Internal Med, Seoul 07260, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu 41944, South Korea; Korea Univ, Ansan Hosp, Dept Internal Med, Ansan 15355, South Korea; Keimyung Univ, Dongsan Hosp, Dept Internal Med, Daegu 42601, South Korea; Seoul Natl Lnivers, Boramae Med Ctr, Seoul Metropolitan Govt, Dept Internal Med, Seoul 07061, South Korea; Wonkwang Univ Hosp, Dept Internal Med, Iksan 54538, South Korea; Kyung Hee Univ, Dept Internal Med, Med Ctr, Seoul 02447, South Korea; Pusan Natl Univ, Sch Med, Dept Internal Med, Busan 47241, South Korea; Pusan Natl Univ Hosp, Biomed Res Inst, Busan 47241, South Korea; KKonkuk Univ, Dept Internal Med, Med Ctr, Seoul 05030, South Korea; Kosin Univ, Dept Internal Med, Gaspel Hosp, Busan 49267, South Korea; Daegu Catholic Univ, Dept Internal Med, Med Ctr, Daegu 42471, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam Si 13620, Gyeonggi Do, South Korea; Samsung Med Ctr, Dept Internal Med, Seoul 06351, South Korea; Chonbuk Natl Univ Hosp, Dept Internal Med, Jeonju Si 54907, South Korea; Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju 61469, South Korea; Chungbuk Natl Univ, Dept Internal Med, Sch Med, Cheongju 28644, South Korea; Severance Hosp, Dept Internal Med, Seoul 03722, South Korea; Catholic Univ Korea, Dept Internal Med, Seoul ST Marys Hosp, Seoul 06591, South Korea; Soonchunhyang Univ, Digest Dis Ctr, Coll Med, Seoul 04401, South Korea; Asan Med Ctr, Dept Internal Med, Seoul 05505, South Korea; Ajou Univ, Dept Gastroenterol, Sch Med, Suwon 16499, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul 06273, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea | Lee, Yong Jae/GLR-4153-2022; Kim, Nayoung/J-5387-2012; Lee, Yoojin/AAB-9799-2022; Kim, Woo/D-2733-2015; Lee, Si/ABH-1408-2020; KIM, SUNG MIN/U-5269-2017; Kwak, Sang Gyu/AAG-4341-2021; Choi, Myung-Gyu/D-6079-2014; Kim, Gwang Ha/ABF-3932-2021; Lee, Ji Ye/ABA-7830-2021; Kim, Ki Bae/KYQ-0127-2024; Lee, Jee-Yon/GER-4141-2022; Kim, Jie-Hyun/Q-9061-2019 | 58001524100; 24477520300; 7202215162; 58252089900; 34770060400; 57218683827; 56903328900; 11239731700; 7408119608; 57215881098; 35214772400; 57226383709; 8666034000; 12779951100; 57201181440; 36067967700; 7601418502; 57210863499; 56106965700; 35264717600; 16635388700; 55888818600; 7403029804; 35345240300; 49461401400; 56403766700 | leeoy@hanyang.ac.kr; | WORLD JOURNAL OF GASTROENTEROLOGY | WORLD J GASTROENTERO | 1007-9327 | 2219-2840 | 28 | 44 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 4.3 | 34.9 | 3.49 | 2025-06-25 | 25 | 31 | Gastroesophageal reflux; Esophagitis; Proton pump inhibitors; Heartburn; Quality of life | COMPETITIVE ACID BLOCKER; QUALITY-OF-LIFE; GASTROESOPHAGEAL-REFLUX DISEASE; PROTON PUMP INHIBITORS; CLINICAL-TRIAL; DOUBLE-BLIND; VS. LANSOPRAZOLE; CHRONIC COUGH; 40 MG; VONOPRAZAN | Esophagitis; Gastroesophageal reflux; Heartburn; Proton pump inhibitors; Quality of life | Adult; Drug-Related Side Effects and Adverse Reactions; Esomeprazole; Esophagitis; Gastrins; H(+)-K(+)-Exchanging ATPase; Humans; Peptic Ulcer; Quality of Life; esomeprazole; fexuprazan; gastrin; esomeprazole; fexuprazan; gastrin; hydrogen potassium adenosine triphosphatase; adult; aged; Article; controlled study; diarrhea; dizziness; double blind procedure; drug efficacy; drug safety; esophagoscopy; female; gastrin blood level; gastroesophageal reflux; healing rate; health care facility; heartburn; human; Korean (people); major clinical study; male; medical decision making; middle aged; multicenter study; parallel design; patient compliance; phase 3 clinical trial; quality of life; randomized controlled trial; reflux esophagitis; South Korea; treatment duration; treatment outcome; treatment response; young adult; adverse drug reaction; esophagitis; peptic ulcer | English | 2022 | 2022-11-28 | 10.3748/wjg.v28.i44.6294 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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