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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Deactivation-Tolerance of Heterojunction Anatase and Bronze TiO2 in the Photocatalytic Mineralization of Toluene | Heterojunctioning anatase (A) and rutile (R) TiO2 is considered a benchmark strategy for high photocatalytic activity. In this study, we synthesized heterojunctions of anatase (A) and bronze (B) TiO2 via hydrothermal and annealing processes using low-cost commercial A-TiO2. The as-synthesized AB-TiO2 shows remarkable activity for toluene mineralization and a strong tolerance to deactivation. The activity and durability of AB-TiO2 far exceed those of A-, R-, B-, and AR-TiO2, which are bare and even Pt-deposited (a total of 10 TiO2 samples). AB-TiO2 exhibits highly active {001} facets for the generation of hydroxyl radicals and oxygen vacancies beneficial for O-2 adsorption. Transient absorption and time-resolved photoluminescence spectroscopies reveal the characteristic lifetimes of electrons and holes. Density functional theory calculations demonstrate facile charge separation and identify the catalytically active surface for oxidation as the anatase surface in AB-TiO2. The observed high activity and durability are analyzed in terms of photochemical and catalytic factors. | Kim, Dong Jin; Park, Jiyeon; Ham, Gayoung; Cha, Hyojung; Han, Dong Suk; Kim, Minho; Park, Hyunwoong | Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Energy Convergence & Climate Change, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea; Qatar Univ, Ctr Adv Mat, Doha 2713, Qatar; Kyung Hee Univ, Dept Appl Chem, Yongin 17104, Gyeonggi, South Korea | Han, Dong Suk/Q-8641-2017; Han, Dong SuK/AAX-9333-2021; Park, Hyunwoong/A-1247-2012; Kim, Minho/AAE-8477-2022 | 57201652080; 57218367393; 58506766600; 35885242200; 36139213900; 57020081700; 7601565583 | minho.kim@khu.ac.kr;hwp@knu.ac.kr; | ACS ES&T ENGINEERING | ACS EST ENG | 2690-0645 | 4 | 10 | ESCI | ENGINEERING, ENVIRONMENTAL | 2024 | 6.7 | 24.7 | 0 | 2025-05-07 | 0 | 0 | heterojunction; bronze; toluene; mineralization; oxygen vacancy | MOLECULAR-DYNAMICS; DEGRADATION; SURFACE; OXIDATION; MECHANISM; HYDROGEN; NANOPARTICLES; SPECTROSCOPY; NANOFIBERS; ELECTRONS | bronze; heterojunction; mineralization; oxygen vacancy; toluene | English | 2024 | 2024-07-23 | 10.1021/acsestengg.4c00281 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Protection and Heat Insulation Performance Comparison using Insulation Formwork in Winter | Concrete pouring in winter is critical to both concrete manufacturers and end users owing to the possibility of concrete damage due to cold weather. In this context, various methods have been used to prevent frost damage to concrete in winter, including adjusting the concrete mix using a chemical admixture and heat-curing with tents. Of these methods, the insulated-gang-form approach does not require concrete-mix adjustment via a chemical-admixture addition. Furthermore, its positive effect on the initial quality of concrete during concrete construction in winter has previously been confirmed. In this study, the power consumption of the conventional gang form was compared with that of the insulated gang form to evaluate the efficiency of the two protection methods. A thermal vision camera was used to examine the surface heat loss of the gang forms after concrete pouring. The insulated gang form significantly outperformed the conventional one through its significantly reduced power consumption and reduced surface heat loss. These findings can contribute to the standardization of insulated gang form application to concrete protection in cold-weather conditions. | Lim, Myung-Kwan; Nam, Kyung-Yong; Choi, Hyeonggil | Univ Ulsan, Dept Architecture Engn, Ulsan 44610, South Korea; Taeyoung E&C Co Ltd, Engn & Construct Grp, Architectural Technol Team, Seoul 07241, South Korea; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea | 56430411000; 57191529756; 56430165800 | kynam@taeyoung.com;hgchoi@knu.ac.kr; | INTERNATIONAL JOURNAL OF CONCRETE STRUCTURES AND MATERIALS | INT J CONCR STRUCT M | 1976-0485 | 2234-1315 | 18 | 1 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 3.6 | 24.7 | 0 | 2025-05-07 | 0 | 0 | Insulated gang form; Cold-weather construction; Concrete protection in winter; Insulation performance | BUILDING CONSTRUCTION; CONCRETE; STRENGTH | Cold-weather construction; Concrete protection in winter; Insulated gang form; Insulation performance | Cold weather problems; Concrete mixing; Energy efficiency; Thermal insulation; Chemical admixture; Cold weather; Cold-weather construction; Concrete protection; Concrete protection in winter; Gang forms; Insulated gang form; Insulation performance; Performance comparison; Surface heat loss; Concrete additives | English | 2024 | 2024-09-27 | 10.1186/s40069-024-00691-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synergistic interfacial interaction in polyetherimide/ZIF-7 mixed matrix membranes for enhanced H2/CO2 2 /CO 2 separation☆ ☆ | Mixed matrix membranes (MMMs), consisting of a continuous polymer phase and a discontinuous molecular sieve phase, present a promising alternative to polymeric membranes for gas separations due to their advantages of high processability with outstanding separation efficiency. The suppression of sieve-in-a-cage and filler agglomerations, major challenges in existing MMMs, is systematically validated through a combination of polyimide and zeolitic imidazolate framework-7 (ZIF-7) nanofillers to enhance the H2/CO2 2 /CO 2 separation performance. The polyetherimide (Ultem) exhibits excellent interfacial interaction with ZIF-7 nanofillers within the MMMs, enabling the accommodation of high ZIF-7 concentrations, up to 40 wt%, due to its hydrophobic nature. The Ultem/ZIF-7 (60/40 wt/wt) MMMs represent significant enhancements in both H2 2 permeability and H2/CO2 2 /CO 2 selectivity, showing increases of 35 % and 65 %, respectively, compared to the pristine Ultem membrane. Furthermore, the enhancement in the intrinsic H2/CO2 2 /CO 2 separation performance of ZIF-7, estimated by the Maxwell equation, is likely attributed to the substantial rigidification of polymer chains in the vicinity of ZIF-7. Additionally, the difference in the activation energy of permeation for H2 2 and CO2 2 distinctly increases with ZIF-7 contents, highlighting the importance of the interfacial interaction in the separation performance of MMMs. | Park, Sunghwan; An, Heseong; Seong, Jeongho; Kim, Sangwoo; Choi, Jungkyu; Lee, Jong Suk | Kyungpook Natl Univ KNU, Dept Energy Chem Engn, 2559 Gyeongsang Daero, Sangju 37224, Gyeongsangbug d, South Korea; Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, 2559 Gyeongsang daero, Sangju 37224, Gyeongsangbuk d, South Korea; Sogang Univ, Dept Chem & Biomol Engn, 35 Baekbeom Ro, Seoul 04107, South Korea; Sunchon Natl Univ, Dept Chem Engn, 255 Jungang Ro, Suncheon Si 57922, Jeonnam Do, South Korea; Korea Univ, Dept Chem & Biol Engn, 145 Anam Ro, Seoul 02841, South Korea; Sogang Univ, Inst Energy & Environm Technol, 35 Baekbeom Ro, Seoul 04107, South Korea; Sogang Univ, Inst Emergent Mat, 35 Baekbeom Ro, Seoul 04107, South Korea | Lee, Jong Suk/AAT-2177-2020 | 56402062100; 57201849393; 57874064100; 59237076700; 12803588200; 35192147100 | jungkyu_choi@korea.ac.kr;jongslee@sogang.ac.kr; | MICROPOROUS AND MESOPOROUS MATERIALS | MICROPOR MESOPOR MAT | 1387-1811 | 1873-3093 | 379 | SCIE | CHEMISTRY, APPLIED;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 4.7 | 24.7 | 0.6 | 2025-05-07 | 3 | 3 | H 2 /CO 2 separation; Zeolitic imidazolate framework; Polyetherimide; Mixed matrix membranes; Interfacial interaction | GAS SEPARATION; PERFORMANCE; DESIGN; TECHNOLOGY; DIFFUSION; POLYMERS; RECOVERY; CO2/CH4 | H<sub>2</sub>/CO<sub>2</sub> separation; Interfacial interaction; Mixed matrix membranes; Polyetherimide; Zeolitic imidazolate framework | Activation energy; Gas permeable membranes; Maxwell equations; Sieves; Gas separations; H2/CO2 separation; Interfacial interaction; Mixed-matrix membranes; Nanofiller; Phase present; Polymer phase; Processability; Separation performance; Zeolitic imidazolate frameworks; Molecular sieves | English | 2024 | 2024-11 | 10.1016/j.micromeso.2024.113267 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Analysing the causes of tourists' emotional experience related to tourist attractions from a binary emotions perspective utilising machine learning models | This study constructs a theoretical framework to analyse the causes of tourists' binary emotional experiences. It applies Support Vector Machine (SVM) and Latent Dirichlet allocation (LDA) machine learning models, combined with geospatial analysis methods, to online reviews of five types of tourist attractions in Dali, China. The results indicate that positive sentiments predominated across Dali Prefecture, though some attractions in Dali City received negative ratings. Furthermore, service experience and price were common influences on tourists' sentiments. This study reveals the causes of tourists' varied emotional experiences at tourist attractions from a binary emotional perspective. | Yin, Xiaoyan; Jung, Taeyeol | Dali Univ, Coll Engn, Dept Architecture, Dali, Peoples R China; Kyungpook Natl Univ, Dept Landscape Architecture, Daegu 41566, South Korea | 58314079400; 55490551100 | jungty@knu.ac.kr; | ASIA PACIFIC JOURNAL OF TOURISM RESEARCH | ASIA PAC J TOUR RES | 1094-1665 | 1741-6507 | 29 | 6 | SSCI | HOSPITALITY, LEISURE, SPORT & TOURISM | 2024 | 3.3 | 24.8 | 1.3 | 2025-04-16 | 2 | 3 | Emotional experience; Latent Dirichlet allocation; online reviews; sentiment analysis; Support Vector Machine; topic modelling | SERVICE QUALITY; SATISFACTION; REVIEWS; DESTINATION; HAPPINESS; RATINGS; INTENTION; SENTIMENT; VACATION; AIRBNB | Emotional experience; Latent Dirichlet allocation; online reviews; sentiment analysis; Support Vector Machine; topic modelling | China; Dali; Yunnan; machine learning; numerical model; spatial analysis; support vector machine; theoretical study; tourist attraction; tourist behavior | English | 2024 | 2024-06-02 | 10.1080/10941665.2024.2343077 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Assessing the influence of climate change on multiple climate indices in Nepal using CMIP6 global climate models | Global climate models (GCMs) serve as essential tools for projecting future climate trends, but their coarse resolution limits localized impact assessments in sectors like hydrology, agriculture, and biodiversity. Observation data with a spatial resolution of a few kilometers are crucial for downscaling and bias-correcting GCMs at finer resolutions. However, Nepal's extreme topography and organizational challenges have led to uneven distribution of meteorological stations and inconsistent data quality. Moreover, CMIP6-based climate extremes projections for the entire country are currently unavailable. To tackle these challenges, we developed a comprehensive national database for Nepal, offering high-resolution historical and projected precipitation and temperature data analyzed through 25 climate extreme indices from the Expert Team on Climate Change Detection and Indices (ETCCDI). Initially, observation grid data were prepared at a daily timescale with a spatial resolution of 0.05 degrees degrees x 0.05 degrees degrees for baseline period (1981-2010) using the Asian Precipitation High-Resolved Observational Data Integration Toward Evaluation (APHRODITE), the fifth generation of the European Centre for Medium-Range Weather Forecasts Reanalysis (ERA5), and available good quality observed climate data. This data was then utilized to downscale and bias-correct 18 CMIP6 GCMs for 2015-2100 under four SSPs (1-2.6, 2-4.5, 3-7.0, 5-8.5). Quantile mapping was employed for the bias correction of the CMIP6 GCMs. The performance of the multimodal ensemble (MME) indicated better Nash-Sutcliffe Efficiency (NSE), root mean square error ratio (RSR), and Percent Bias (PBIAS) of climate extreme indices for the historical period. A comparative analysis was conducted across Nepal's major geographic regions to account for spatial variability in regional climate systems. The finer-resolution dataset can be crucial to deepen our understanding of climate impacts, and climate change, and eventually informing the policy-making in Nepal. Moreover, the methodology can be effectively replicated in data-scarce developing nations to promote climate research and adaptation efforts. | Bastola, Shiksha; Cho, Jaepil; Kam, Jonghun; Jung, Younghun | Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, Sangju, South Korea; Integrated Watershed Management Inst, Seoul, South Korea; POSTECH, Div Environm Sci & Engn, Pohang, South Korea | Kam, Jonghun/P-8573-2019 | 57202955572; 7403536191; 55746165100; 55195880200 | y.jung@knu.ac.kr; | ATMOSPHERIC RESEARCH | ATMOS RES | 0169-8095 | 1873-2895 | 311 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 4.4 | 24.8 | 0.5 | 2025-05-07 | 2 | 2 | Climate change; CMIP6; Global climate models (GCMs); Climate Indices; Nepal; Shared Socioeconomic Pathways (SSPs) | CHANGE IMPACTS; PRECIPITATION; SYSTEM; ASIA | Climate change; Climate Indices; CMIP6; Global climate models (GCMs); Nepal; Shared Socioeconomic Pathways (SSPs) | Nepal; Miocene; Climate extreme indices; Climate index; CMIP6; Fine resolution; Global climate model; Global climates; Nepal; Shared socioeconomic pathway; Socio-economics; Spatial resolution; air temperature; climate change; climate modeling; CMIP; database; global climate; precipitation (climatology); regional climate; Abiotic | English | 2024 | 2024-12-01 | 10.1016/j.atmosres.2024.107720 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Diagnostic and prognostic implications of bacteremia in patients with complicated pleural infection | Objectives: The clinical significance of bacteremia in patients with complicated pleural infection is still uncertain. We aimed to examine the incidence and clinical significance of bacteremia in patients with complicated pleural infection. Methods: This retrospective study comprised of consecutive patients who received pleural drainage due to complicated parapneumonic effusion or empyema. The clinical, laboratory, and radiologic data and clinical outcome were compared between patients with and without bacteremia. Additionally, the factors associated with overall mortality were evaluated in these patients. Results: Of 341 patients included in the analysis, 25 (7 %) had a positive blood culture. Blood culture testing added 2 % identification of causative pathogen compared to pleural fluid culture alone. By multivariable analysis, radiologic features of cavitary lesion, a RAPID score >= 5, and a positive microbial culture in pleural fluid were independently associated with bacteremia. Despite these clinical distinctions, there was ultimately no significant difference in in-hospital mortality between patients with and without bacteremia (3 vs. 4 %, p=1.0). The only factor significantly associated with overall mortality among patients with complicated pleural infections was a higher RAPID score [HR=1.96 (95 % CI=1.35-2.84)]. Conclusions: The rate of bacteremia in patients with complicated pleural infection was 7 %. Blood culture testing demonstrated limited diagnostic yield and had minimal impact on clinical outcomes compared to pleural fluid culture. Therefore, it seems that blood culture testing is more advantageous for specific patients with suspected pleural infection who have cavitary lesions or a RAPID score >= 5. | Kim, Chang Ho; Park, Ji Eun; Cha, Jung Guen; Lim, Jae Kwang; Park, Jongmin; Lee, Yong Hoon; Choi, Sun Ha; Seo, Hyewon; Yoo, Seung Soo; Lee, Shin Yup; Cha, Seung Ick; Park, Jae Yong; Lee, Jaehee | Kyungpook Natl Univ, Sch Med, Dept Internal Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea | Lee, You/T-6086-2019; Lee, Jun Young/CAI-2335-2022; Park, Jae Yong/ISS-5916-2023; Lee, Jaehee/S-1697-2018 | 7409873555; 57195437358; 57206855971; 55515341400; 57216463879; 57199022948; 57199723585; 55612130200; 56479781600; 49863712700; 35227126400; 58360293800; 13805476000 | jaelee@knu.ac.kr; | PLEURA AND PERITONEUM | PLEURA PERITONEUM | 2364-7671 | 2364-768X | 9 | 2 | ESCI | ONCOLOGY;SURGERY | 2024 | 2.4 | 24.8 | 0 | 2025-05-07 | 0 | 0 | pleural infection; empyema; bacteremia; outcome; microbiology | COMMUNITY-ACQUIRED PNEUMONIA; BLOOD CULTURES; BACTERIOLOGY; MANAGEMENT; MORTALITY; UTILITY | bacteremia; empyema; microbiology; outcome; pleural infection | antibiotic agent; biological marker; serum albumin; adult; aged; alpha hemolytic Streptococcus; Article; bacteremia; blood culture; case fatality rate; clinical outcome; clinical significance; comparative study; computer assisted tomography; controlled study; electronic medical record; evaluation study; female; human; in-hospital mortality; incidence; information processing; informed consent; major clinical study; male; methicillin resistant Staphylococcus aureus; mortality rate; multidrug resistance; Mycobacterium; overall survival; pleura fluid; pleurisy; retrospective study; Staphylococcus; Streptococcus sanguinis; tertiary care center; thorax radiography; urea nitrogen blood level | English | 2024 | 2024-06-26 | 10.1515/pp-2023-0044 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effects of horizontal resolution and updated surface data on simulated low-level winds for the aviation safety over Incheon International Airport | This study aimed to alleviate the overestimation of low-level wind speeds at Incheon International Airport in South Korea by employing large eddy simulation (LES) modeling and high-resolution surface data. Simulation and observation data from two days on which potentially hazardous weather conditions near the airport were observed were selected for analysis: 12 August 2020, when strong winds were recorded, and 13 July 2020, when precipitation occurred. To investigate the impact of the horizontal resolution of the model and updated land surface data on low-level wind simulations, this study compared the simulation results of 1 km experiments with both 30-s United States Geological Survey topography and land use data and high-resolution 3-s surface data, including Shuttle Radar Topography Mission digital elevation model topography data and land use data generated by the Korean Ministry of Environment, and 100 m LES experiments with the high-resolution surface data. The observed 10-m wind speed and sonde data near the airport were used to evaluate the model results. Utilizing the updated high-resolution surface data in the 1 km model grid-spacing simulation led to a lower root mean square error and wind speed bias compared to the use of low-resolution surface data. The 100 m experiment incorporating LES modeling with the updated high-resolution surface data further improved the low-level wind simulation results compared to the 1 km experiment using the same high-resolution surface data. In addition to providing more accurate simulations of mean winds, turbulence variations over the airport and the nearby region are better resolved by using high-resolution LES modeling and combined with updated surface data, which are critical for ensuring aviation safety near the airport. | Lee, Hyeon-Ji; Shin, Hyeyum Hailey; Lim, Kyo-Sun Sunny; Park, Sang-Hun | Kyungpook Natl Univ, Ctr Atmospher Remote Sensing CARE, Dept Atmospher Sci, Weather Extremes Educ & Res Team BK21, Daegu, South Korea; Natl Ctr Atmospher Res, Boulder, CO 80305 USA; Yonsei Univ, Dept Atmospher Sci, Seoul, South Korea | Lim, Kyo-Sun/I-3811-2012 | 57744813600; 54992767300; 57211926026; 55189671700 | hshin@ucar.edu;kyosunlim@knu.ac.kr; | ATMOSPHERIC RESEARCH | ATMOS RES | 0169-8095 | 1873-2895 | 312 | SCIE | METEOROLOGY & ATMOSPHERIC SCIENCES | 2024 | 4.4 | 24.8 | 0 | 2025-05-07 | 0 | 0 | High-resolution surface data; Large eddy simulation; WRF; 10-m wind speed | SCALE OROGRAPHY PARAMETERIZATION; COMPLEX TERRAIN; WRF MODEL; REPRESENTATION; IMPACTS; SYSTEM; FIELDS | 10-m wind speed; High-resolution surface data; Large eddy simulation; WRF | Incheon [South Korea]; South Korea; Geological surveys; Wind effects; 10-m wind speed; High resolution; High-resolution surface data; Horizontal resolution; Large eddy simulation models; Large-eddy simulations; Low-level winds; Surface data; Wind speed; WRF; airport; climate conditions; large eddy simulation; Shuttle Radar Topography Mission; transportation safety; turbulence; wind velocity; Digital elevation model | English | 2024 | 2024-12-15 | 10.1016/j.atmosres.2024.107753 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A Spectrophotometric Method to Determine Minimal Erythema Dose for Ultraviolet Radiation in Human Skin | Background/Objectives: Ultraviolet radiation (UVR) induces oxidative stress in the skin by generating reactive oxygen species (ROS), which can lead to inflammatory conditions including erythema (a sign of sunburn). This clinical study aims to develop an instrumental evaluation method to determine the minimal erythema dose (MED) for UVR. Methods: Fourteen human subjects aged 27 to 57 years (48.93 +/- 8.54) participated in this study. Six subsites were designated on the test skin site of each subject and irradiated with UVR at different doses. The examiner visually assessed erythema, determining the 'visual MED'. Additionally, the a* value (a chrominance parameter presenting greenness to redness) was measured using a spectrophotometer as an indicator of erythema. The a* values of the UVR-irradiated subsites were compared to the non-irradiated control value, and the differences were referred to as Delta a*. The Delta a* value of the subsites irradiated with UVR at the 'visual MED' was referred to as the Delta a*VMED for each subject. The mean of the Delta a*VMED values of all subjects was chosen as a criterion value for the 'instrumental MED'. The 'instrumental MED' was defined as the lowest dose of UVR that causes an Delta a* value equivalent to the criterion value. The 'visual MED' and 'instrumental MED' values of all subjects were subjected to correlation analysis. Results: The mean of the Delta a*VMED values of all subjects was 1.88 +/- 0.8. The means of the 'visual MED' and 'instrumental MED' values (in J m-2 unit) of all subjects were 300.14 +/- 84.16 and 303.29 +/- 77.99, respectively. In Pearson correlation analysis, the 'instrumental MED' and 'visual MED' values had a very strong positive correlation with each other (r = 0.864, p = 0.000). Conclusions: This study suggests that the instrumental evaluation method of MED based on the spectrophotometric measurement of the a* values can complement or replace the visual evaluation method and that this method will be useful in monitoring skin tolerance to oxidative stress affected by prooxidant factors and defensive factors. | Lee, Eun Ju; Lee, Chung Han; Baek, Ji Hwoon; Koh, Jae Sook; Boo, Yong Chool | Dermapro Ltd, Skin Res Ctr, Seoul 06570, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea | 59119256000; 59442425600; 59863276200; 35234232700; 6602899130 | pololi-3@hanmail.net;ohplaza@naver.com;jhun100@nate.com;dermapro@dermapro.co.kr;ycboo@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 12 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 3.9 | 24.9 | 0 | 2025-05-07 | 0 | 0 | minimal erythema dose; MED; ultraviolet radiation; UVR; erythema; redness; a* value; oxidative stress; spectrophotometer; instrumental evaluation | MELANIN | a* value; erythema; instrumental evaluation; MED; minimal erythema dose; oxidative stress; redness; spectrophotometer; ultraviolet radiation; UVR | English | 2024 | 2024-11 | 10.3390/biomedicines12112544 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Bone Marrow Stem Cell Population in Single- and Multiple-Level Aspiration | Background: Bone marrow aspiration concentrate (BMAC) has garnered increasing interest due to its potential for healing musculoskeletal injuries. While the iliac crest remains a common harvest site, the aspiration technique's efficacy in offering the highest yield and prevalence of mesenchymal stem cells (MSCs) is controversial. This study aimed to compare two different techniques of bone marrow aspiration over the anterior iliac crest from a single level versus multiple levels. Methods: Anterior iliac crests were selected in seven adult patients (aged between 31 and 59 years old). Aspiration was achieved using an 11-gauge needle (length: 100 mm; diameter: 2.3 mm) specifically manufactured for bone marrow collection (BD, Becton, Franklin Lakes, NJ, USA) connected to a 10 mL syringe. On one side, 4cc of bone marrow was aspirated at a single level to a depth of 7 cm without changing the needle direction. On the other side, over the same portion of the iliac crest, 1 cc of bone marrow was obtained from multiple levels of different depths during needle retrieval, maintaining a distance of 1 cm and changing the tip direction. The samples were blindly sent to the laboratory without indicating whether they came from an single level or multiple levels. Fluorescence-activated cell sorting (FACS) and osteoblast differentiation were analyzed and compared. Results: In the FACS analysis, the single level resulted in a higher population of MSCs that were positive for CD105, CD73, and CD90 and negative for CD34, compared to the multiple-level method. In the process of osteoblast differentiation, it was observed that MSCs exhibited more advanced features of enhanced osteoblastic abilities in the single-level method rather than the multiple-level method. Conclusions: A single-level aspiration technique at the anterior iliac crest may produce a high-quality bone marrow aspirate. This technique may help obtain specific populations of MSCs with the desired characteristics for use in regenerative therapies for musculoskeletal injuries. | Che, Xiangguo; Kim, Hee-June; Jin, Xian; Kim, Joon-Woo; Park, Kyeong-Hyeon; Lim, Jeong-Ok; Kyung, Hee-Soo; Oh, Chang-Wug; Choi, Je-Yong | Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, Daegu 41944, South Korea; Yonsei Univ, Severance Childrens Hosp, Coll Med, Dept Pediat, Seoul 03722, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu 41940, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu 41940, South Korea | ; Choi, Je-Yong/AAR-7334-2021; Oh, Chang-Wug/AAO-4602-2021; Park, KyeongHyeon/KEH-4919-2024 | 54792660600; 36463735200; 57204810645; 22951329000; 56969984400; 7403454245; 7004292406; 22135834200; 7501391068 | xiangguo0622@naver.com;june0104@daum.net;kimhan911021@naver.com;orthopedics@naver.com;pkh1112@gmail.com;jolim@knu.ac.kr;hskyung@knu.ac.kr;cwoh@knu.ac.kr;jechoi@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 12 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 3.9 | 24.9 | 0 | 2025-05-07 | 0 | 0 | bone marrow aspiration concentrate; mesenchymal stem cells; single level; multiple levels; musculoskeletal injuries | THERAPY | bone marrow aspiration concentrate; mesenchymal stem cells; multiple levels; musculoskeletal injuries; single level | English | 2024 | 2024-12 | 10.3390/biomedicines12122731 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Cell Death in Liver Disease and Liver Surgery | Cell death is crucial for maintaining tissue balance and responding to diseases. However, under pathological conditions, the surge in dying cells results in an overwhelming presence of cell debris and the release of danger signals. In the liver, this gives rise to hepatic inflammation and hepatocellular cell death, which are key factors in various liver diseases caused by viruses, toxins, metabolic issues, or autoimmune factors. Both clinical and in vivo studies strongly affirm that hepatocyte death serves as a catalyst in the progression of liver disease. This advancement is characterized by successive stages of inflammation, fibrosis, and cirrhosis, culminating in a higher risk of tumor development. In this review, we explore pivotal forms of cell death, including apoptosis, pyroptosis, and necroptosis, examining their roles in both acute and chronic liver conditions, including liver cancer. Furthermore, we discuss the significance of cell death in liver surgery and ischemia-reperfusion injury. Our objective is to illuminate the molecular mechanisms governing cell death in liver diseases, as this understanding is crucial for identifying therapeutic opportunities aimed at modulating cell death pathways. | Stoess, Christian; Choi, Yeon-Kyung; Onyuru, Janset; Friess, Helmut; Hoffman, Hal M.; Hartmann, Daniel; Feldstein, Ariel E. | Univ Calif San Diego, Dept Pediat Gastroenterol, 9500 Gilman Dr, La Jolla, CA 92093 USA; Tech Univ Munich, TUM Sch Med, Dept Surg, Klinikum Rechts Der Isar, D-81675 Munich, Germany; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea; Univ Calif San Diego, Dept Pediat Allergy Immunol & Rheumatol, La Jolla, CA 92093 USA; Novo Nord, Global Drug Discovery, Orestads Blvd 108, DK-2300 Copenhagen, Denmark | ; Friess, Helmut/ABO-1348-2022; Stoess, Christian/HJZ-4129-2023 | 56823517700; 35335932600; 57844481500; 36049095700; 7201677513; 57197985481; 7003647955 | christian.stoess@tum.de;daniel.hartmann@tum.de;afeldstein@health.ucsd.edu; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 12 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 3.9 | 24.9 | 1.35 | 2025-05-07 | 6 | 7 | cell death; pyroptosis; apoptosis; ferroptosis; cancer; liver surgery; liver disease | ISCHEMIA-REPERFUSION INJURY; HEPATIC STELLATE CELLS; NLRP3 INFLAMMASOME; APOPTOTIC CELLS; DANGER SIGNALS; NONALCOHOLIC STEATOHEPATITIS; MITOCHONDRIAL DYSFUNCTION; ALCOHOLIC STEATOHEPATITIS; INACTIVATION PROTECTS; KUPFFER CELLS | apoptosis; cancer; cell death; ferroptosis; liver disease; liver surgery; pyroptosis | English | 2024 | 2024-03 | 10.3390/biomedicines12030559 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Comprehensive Transcriptomic Profiling of Diverse Brain Tumor Types Uncovers Complex Structures of the Brain Tumor Microenvironment | Various types of brain tumors occur in both children and adults. These tumors manifest with different characteristics such as malignancy, cellular lineage, location of origin, and genomic profile. Recently, immunotherapy, which manipulates immune cells in the tumor microenvironment (TME) to kill tumor cells, has attracted attention as a treatment strategy for tumors. Here, we analyzed the transcriptomic architecture of the brain tumor microenvironment to provide potential guidelines to overcome the therapeutic vulnerabilities to brain tumors. We decomposed the cellular populations of six brain tumor types (meningioma, pilocytic astrocytoma, ependymoma, medulloblastoma, glioblastoma, and lower-grade glioma) using publicly available microarray data and single-cell RNA sequencing (scRNA-seq) data. Interestingly, transcriptome-based immune cell profiling revealed that infiltrating immune cell types in the brain TME, particularly M2 macrophages, CD8+ T cells, and CD4+ T cells, could be distinguished by tumor type, malignancy, and location. scRNA-seq revealed differences in the proportions of dendritic and mural cells. Unsupervised clustering using immune-related genes divided all samples into two distinct clusters with different characteristics. In addition, immune subpopulations showed disparate reactions after anti-PD-1 therapy for glioblastoma. Our results unveiled the distinct TME across brain tumor types and provided a transcriptomic landscape. Our findings may contribute to realizing future precision medicine, providing a basic rationale for the therapeutics of brain tumors. | Choi, Jiin; Cho, Hee Jin | Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea | 58956420300; 55937716400 | djm04018@knu.ac.kr;heejincho@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 12 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 3.9 | 24.9 | 0.53 | 2025-05-07 | 1 | 1 | brain tumor; tumor microenvironment; transcriptome analysis; single-cell RNA sequencing | CENTRAL-NERVOUS-SYSTEM; IMMUNE LANDSCAPE; DENDRITIC CELLS; GENE; GLIOBLASTOMA; EXPRESSION; CLASSIFICATION; ENRICHMENT; MUTATIONS; SUBGROUPS | brain tumor; single-cell RNA sequencing; transcriptome analysis; tumor microenvironment | English | 2024 | 2024-03 | 10.3390/biomedicines12030506 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | MULTI-OBJECTIVE GREEN DESIGN MODEL BASED ON COSTS, CO2 EMISSIONS AND SERVICEABILITY FOR HIGH-RISE BUILDINGS WITH A MEGA-STRUCTURE SYSTEM | In light of growing environmental concerns, the reduction of CO 2 emissions is increasingly vital. Particularly in the construction industry, a major contributor to global carbon emissions, addressing this issue is critical for environmental sustainability and mitigating the accelerating impacts of climate change. This study proposes the Optimal Green Design Model for Mega Structures (OGDMM) to optimise CO 2 emissions, cost-effectiveness, and serviceability in highrise buildings with mega structures. The OGDMM examines the impact of each material and structural design of main members on these three critical aspects. Analytical results for high-rise buildings (120-200 m, slenderness ratio: 2.0-8.0) demonstrate that OGDMM can reduce CO 2 emissions and costs by an average of 4.67% and 3.97%, respectively, without compromising serviceability. To ensure comprehensive evaluation, this study introduces five new evaluation indicators encompassing environmental, economic, and serviceability performances of high-rise buildings. Based on these criteria, optimised structural designs for high-rise buildings are classified into four categories according to slenderness ratio, leading to the formulation of corresponding design guidelines. The model's applicability is further validated through its application to a 270-m-tall high-rise building in Korea, showing reductions in CO 2 emissions and costs by 8.99% and 18.50%, respectively, while maintaining structural serviceability. | Choi, Jewoo; Lee, Seung Hyeong; Hong, Taehoon; Lee, Dong-Eun; Park, Hyo Seon | Yonsei Univ, Dept Architectural Engn, Seoul, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil & Architectural Engn, Daegu, South Korea | Choi, Jewoo/MGT-4857-2025 | 57205453819; 57222242872; 57969349700; 56605563300; 55669886900 | hspark@yonsei.ac.kr; | JOURNAL OF CIVIL ENGINEERING AND MANAGEMENT | J CIV ENG MANAG | 1392-3730 | 1822-3605 | 30 | 4 | SCIE | ENGINEERING, CIVIL | 2024 | 3.7 | 24.9 | 0 | 2025-05-07 | 0 | 0 | structural optimisation; green design; high-rise building; mega-structure system; serviceability | REINFORCED-CONCRETE STRUCTURES; SUSTAINABLE DESIGN; GENETIC-ALGORITHM; OPTIMIZATION; FRAMES | green design; high-rise building; mega-structure system; serviceability; structural optimisation | Architectural design; Carbon dioxide; Climate change; Construction industry; Cost effectiveness; Cost reduction; Ecodesign; Structural design; Sustainable development; Tall buildings; % reductions; CO 2 emission; Design models; High rise building; Mega-structure; Mega-structure system; Serviceability; Slenderness ratios; Structural optimisations; Structure systems; Structural optimization | English | 2024 | 2024 | 10.3846/jcem.2024.21357 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Nanofiber Graft Therapy to Prevent Shoulder Stiffness and Adhesions after Rotator Cuff Tendon Repair: A Comprehensive Review | Stiffness and adhesions following rotator cuff tears (RCTs) are common complications that negatively affect surgical outcomes and impede healing, thereby increasing the risk of morbidity and failure of surgical interventions. Tissue engineering, particularly through the use of nanofiber scaffolds, has emerged as a promising regenerative medicine strategy to address these complications. This review critically assesses the efficacy and limitations of nanofiber-based methods in promoting rotator cuff (RC) regeneration and managing postrepair stiffness and adhesions. It also discusses the need for a multidisciplinary approach to advance this field and highlights important considerations for future clinical trials. | Yoon, Jong Pil; Kim, Hyunjin; Park, Sung-Jin; Kim, Dong-Hyun; Kim, Jun-Young; Kim, Du Han; Chung, Seok Won | Kyungpook Natl Univ, Sch Med, Dept Orthoped Surg, Daegu 41944, South Korea; Catholic Univ, Sch Med, Dept Orthoped Surg, Daegu 38430, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Dept Orthoped Surg, Daegu 42601, South Korea; Konkuk Univ, Med Ctr, Dept Orthoped Surg, Seoul 05030, South Korea | , Do Hyun Kim/J-4567-2017 | 36098548400; 58843093300; 58527890700; 57198637188; 57201935381; 57192702203; 37065938600 | altjp1@gmail.com;knuhos_sh2@naver.com;miniself@hanmail.net;kdh8110@hanmail.net;dr.junyoung@gmail.com;osmdkdh@gmail.com;smilecsw@gmail.com; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 12 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 3.9 | 24.9 | 0 | 2025-05-07 | 2 | 1 | rotator cuff tears; shoulder stiffness and adhesions; nanofiber scaffolds; tissue engineering; clinical trials | MECHANICAL-PROPERTIES; POLYMERIC NANOFIBERS; MINI-OPEN; BIOMATERIALS; MANAGEMENT; MEMBRANES; SCAFFOLD; OUTCOMES; MODEL; TEARS | clinical trials; nanofiber scaffolds; rotator cuff tears; shoulder stiffness and adhesions; tissue engineering | English | 2024 | 2024-07 | 10.3390/biomedicines12071613 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Sodium Phenylbutyrate Attenuates Cisplatin-Induced Acute Kidney Injury Through Inhibition of Pyruvate Dehydrogenase Kinase 4 | Background/Objectives: Cisplatin nephrotoxicity is a significant clinical issue, and currently, no approved drug exists to prevent cisplatin-induced acute kidney injury (AKI). This study investigated whether sodium phenylbutyrate (4-PBA), a chemical chaperone, can prevent cisplatin-induced AKI. Methods: Six consecutive days of intraperitoneal injections of 4-PBA were administered in a murine model before and after the cisplatin challenge. This study evaluated tubular injury, serum blood urea nitrogen (BUN) and creatinine levels, and inflammatory markers such as tumor necrosis factor-alpha (TNF-alpha) and intercellular adhesion molecule 1 (ICAM-1). Additionally, apoptosis, mitochondrial membrane potential, oxygen consumption ratio, and reactive oxygen species (ROS) were assessed in renal tubular cells. The expression levels of pyruvate dehydrogenase kinase 4 (Pdk4) were also analyzed. Results: 4-PBA prevented tubular injury and normalized serum BUN and creatinine levels. Inflammatory markers TNF-alpha and ICAM-1 were suppressed. In renal tubular cells, 4-PBA reduced apoptosis, restored mitochondrial membrane potential and oxygen consumption ratio, and reduced ROS production. Mechanistically, 4-PBA suppressed the expression of Pdk4, which is known to be induced during cisplatin-induced renal injury. The protective effect of 4-PBA was abolished in Pdk4-overexpressing renal tubular cells, indicating that the efficacy of 4-PBA partially depends on the suppression of Pdk4 expression. In cancer cells, 4-PBA did not interfere with the anti-cancer efficacy of cisplatin. Conclusions: These findings suggest that 4-PBA effectively prevents cisplatin-induced acute kidney injury by suppressing Pdk4. | Oh, Chang Joo; Choi, Wooyoung; Lee, Ha Young; Lee, In-Kyu; Kim, Min-Ji; Jeon, Jae-Han | Kyungpook Natl Univ, Res Inst Aging & Metab, Sch Med, Daegu 41404, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med, Daegu 41404, South Korea | Lee, Ha/ABF-6005-2020; Kim, Minji/AAQ-2339-2020; Lee, In-Kyu/AAR-6374-2021 | 14049080600; 59489139400; 59489353600; 36071537600; 57206189095; 36910340400 | kmj_endo@knuh.kr;jeonjh@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 12 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 3.9 | 24.9 | 0 | 2025-05-07 | 0 | 0 | cisplatin nephrotoxicity; acute kidney injury; sodium phenylbutyrate; pyruvate dehydrogenase kinase 4; inflammation; apoptosis | ER STRESS; CANCER; NEPHROTOXICITY; CELLS | acute kidney injury; apoptosis; cisplatin nephrotoxicity; inflammation; pyruvate dehydrogenase kinase 4; sodium phenylbutyrate | English | 2024 | 2024-12 | 10.3390/biomedicines12122815 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | The Potential of Mesenchymal Stem Cells in Treating Spinocerebellar Ataxia: Advances and Future Directions | Spinocerebellar ataxia (SCA) is a heterogeneous disorder characterized by impaired balance and coordination caused by cerebellar dysfunction. The absence of treatments approved by the U.S. Food and Drug Administration for SCA has driven the investigation of alternative therapeutic strategies, including stem cell therapy. Mesenchymal stem cells (MSCs), known for their multipotent capabilities, have demonstrated significant potential in treating SCA. This review examines how MSCs may promote neuronal growth, enhance synaptic connectivity, and modulate brain inflammation. Recent findings from preclinical and clinical studies are also reviewed, emphasizing the promise of MSC therapy in addressing the unmet needs of SCA patients. Furthermore, ongoing clinical trials and future directions are proposed to address the limitations of the current approaches. | Lee, Gi Beom; Park, Se Min; Jung, Un Ju; Kim, Sang Ryong | Kyungpook Natl Univ, Sch Life Sci & Biotechnol, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Food Sci & Nutr, Busan 48513, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41404, South Korea | 59441620700; 59442160200; 7007119425; 56486163800 | gibuom7@naver.com;qkrtpals89@naver.com;jungunju@pknu.ac.kr;srk75@knu.ac.kr; | BIOMEDICINES | BIOMEDICINES | 2227-9059 | 12 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY | 2024 | 3.9 | 24.9 | 0 | 2025-05-07 | 1 | 1 | spinocerebellar ataxia; mesenchymal stem cells; immunomodulation; homing ability | STROMAL CELLS; ALZHEIMERS-DISEASE; ADIPOSE-TISSUE; TRANSPLANTATION; THERAPY; SAFETY; MECHANISMS; DEGENERATION; NEURONS; MODELS | homing ability; immunomodulation; mesenchymal stem cells; spinocerebellar ataxia | English | 2024 | 2024-11 | 10.3390/biomedicines12112507 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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