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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Characterization of a Novel Phage φAb1656-2 and Its Endolysin with Higher Antimicrobial Activity against Multidrug-Resistant Acinetobacter baumannii | Acinetobacter baumannii is a nosocomial pathogen, which is a problem worldwide due to the emergence of a difficult-to-treat multidrug-resistant A. baumannii (MDRAB). Endolysins are hydrolytic enzymes produced by a bacteriophage that can be used as a potential therapeutic agent for multidrug-resistant bacterial infection in replacing antibiotics. Here, we isolated a novel bacteriophage through prophage induction using mitomycin C from clinical A. baumannii 1656-2. Morphologically, phi Ab1656-2 was identified as a Siphoviridae family bacteriophage, which can infect MDRAB. The whole genome of phi Ab1656-2 was sequenced, and it showed that it is 50.9 kb with a G + C content of 38.6% and 68 putative open reading frames (ORFs). A novel endolysin named AbEndolysin with an N-acetylmuramidase-containing catalytic domain was identified, expressed, and purified from phi Ab1656-2. Recombinant AbEndolysin showed significant antibacterial activity against MDRAB clinical strains without any outer membrane permeabilizer. These results suggest that AbEndolysin could represent a potential antimicrobial agent for treating MDRAB clinical isolates. | Kim, Kyeongmin; Islam, Md Maidul; Kim, Dooyoung; Yun, Sung Ho; Kim, Jungmin; Lee, Je Chul; Shin, Minsang | Kyungpook Natl Univ, Sch Med, Dept Microbiol, 680 Gukchaebosang Ro, Daegu 680, South Korea; Korea Basic Sci Inst, Biochem Anal Team, 162 Yeongudanji Ro, Ochang Eup 28119, Cheongju Si, South Korea | Islam, Md. Maidul/AAE-6691-2022 | 57216604095; 57216605059; 57270622500; 36828356500; 57211297681; 25930392000; 7401536650 | rudals0691@knu.ac.kr;islammm@knu.ac.kr;dtwin@knu.ac.kr;sungho@kbsi.re.kr;minkim@knu.ac.kr;leejc@knu.ac.kr;shinms@knu.ac.kr; | VIRUSES-BASEL | VIRUSES-BASEL | 1999-4915 | 13 | 9 | SCIE | VIROLOGY | 2021 | 5.818 | 36.5 | 0.63 | 2025-07-30 | 8 | 9 | bacteriophage; genome sequencing; endolysin; antimicrobial activity; Acinetobacter baumannii | BACTERIOPHAGE THERAPY; PATHOGENS; BIOFILM | Acinetobacter baumannii; Antimicrobial activity; Bacteriophage; Endolysin; Genome sequencing | Acinetobacter baumannii; Acinetobacter Infections; Anti-Bacterial Agents; Catalytic Domain; Drug Resistance, Multiple, Bacterial; Endopeptidases; Genome, Viral; Humans; Microbial Interactions; Microbial Sensitivity Tests; Protein Conformation; Recombinant Proteins; Siphoviridae; Viral Proteins; Whole Genome Sequencing; ampicillin; genomic DNA; lysozyme; xylan endo 1,3 beta xylosidase; antiinfective agent; endolysin, Acinetobacter baumannii phage; proteinase; recombinant protein; viral protein; Acinetobacter baumannii; amino acid sequence; antibacterial activity; antibiotic resistance; antimicrobial activity; Article; bacterial cell wall degradation; bacterial growth; bacterial strain; bacterial virulence; bacteriophage; bacterium culture; bacterium identification; bacterium isolation; biofilm; catalytic efficiency; controlled study; DNA damage; DNA extraction; Enterococcus faecium; enzyme active site; enzyme activity; Escherichia coli; gene expression; gene overexpression; human; minimum inhibitory concentration; nonhuman; open reading frame; phylogeny; plant gene; plaque assay; plasmid; protein purification; Pseudomonas aeruginosa; Siphoviridae; Staphylococcus aureus; taxonomy; transmission electron microscopy; whole genome sequencing; Acinetobacter baumannii; Acinetobacter infection; chemistry; drug effect; genetics; isolation and purification; microbial sensitivity test; microbiology; multidrug resistance; organismal interaction; physiology; protein conformation; virology; virus genome | English | 2021 | 2021-09 | 10.3390/v13091848 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Compassionate Use of GC5131 (Hyperimmunoglobulin) Therapy in Critically Ill Patients Diagnosed with COVID-19: A Case Series and Review of Literature | Presently, the use of convalescent plasma and hyperimmunoglobulin obtained from individuals who have recovered from coronavirus disease 2019 (COVID-19) has proved to potentially provide passive antibody-based immunity, thereby leading to several clinical trials to develop an immune-based COVID-19 treatment. However, the therapeutic efficacy of hyperimmunoglobulin in critically ill patients with COVID-19 remains unknown. On 23 October 2020, we first administered GC5131 in a compassionate-use program to critically ill patients at the Kyungpook National University, Chilgok Hospital, Korea. Since then, five more critically ill patients were treated with GC5131 in this compassionate-use program in our hospital up until 17 December 2020. We retrospectively reviewed the clinical responses of six critically ill patients diagnosed with COVID-19 who received the hyperimmunoglobulin concentrate, GC5131, which was produced by the Green Cross Corporation. After the administration of GC5131, five patients died due to an exacerbation of COVID-19 pneumonia. GC5131 was ineffective when administered to critically ill patients with COVID-19. Nevertheless, we propose that to expect a therapeutic effect from GC5131, it should be administered as early as possible to avoid the excessive inflammatory response phase in patients with severe and advanced COVID-19 infection. This step was difficult to achieve in the real world due to the time required for decision making and the process of the compassionate-use program. | Choi, Sunha; Hwang, Soyoon; Kwon, Kitae | Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Div Pulm Dis, Daegu 47404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Div Infect Dis, Daegu 47404, South Korea | Kim, Hanjin/KYP-2633-2024; Hwang, Soyoon/HHM-5762-2022; Choi, Sun Ha/HPD-7234-2023 | 57199723585; 57203160675; 9733850500 | sunha20@gmail.com;sangod86@naver.com;ktkwon@knu.ac.kr; | VIRUSES-BASEL | VIRUSES-BASEL | 1999-4915 | 13 | 9 | SCIE | VIROLOGY | 2021 | 5.818 | 36.5 | 0 | 2025-07-30 | 0 | 0 | COVID-19; immunoglobulin; convalescence; plasma; clinical effectiveness | Clinical effectiveness; Convalescence; COVID-19; Immunoglobulin; Plasma | Aged; Compassionate Use Trials; COVID-19; Critical Illness; Female; Humans; Immunization, Passive; Immunoglobulins; Male; Republic of Korea; SARS-CoV-2; Treatment Outcome; amikacin; azithromycin; ceftriaxone; colistin; cotrimoxazole; dexamethasone; doripenem; fluconazole; gc 5131; gentamicin; hyperimmune globulin; levofloxacin; meropenem; metronidazole; moxifloxacin; piperacillin plus tazobactam; remdesivir; teicoplanin; unclassified drug; vancomycin; immunoglobulin; adult; aged; Article; cause of death; chronic obstructive lung disease; clinical article; cohort analysis; continuous renal replacement therapy; coronavirus disease 2019; critically ill patient; female; human; hypertrophic cardiomyopathy; male; middle aged; prostate hypertrophy; real time reverse transcription polymerase chain reaction; respiratory failure; retrospective study; RNA extraction; single drug dose; virus load; virus replication; case report; compassionate use; critical illness; diagnosis; drug effect; drug therapy; passive immunization; South Korea; therapy; treatment outcome; virology | English | 2021 | 2021-09 | 10.3390/v13091826 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Genetic Characterization of Novel H7Nx Low Pathogenic Avian Influenza Viruses from Wild Birds in South Korea during the Winter of 2020-2021 | Zoonotic infection with avian influenza viruses (AIVs) of subtype H7, such as H7N9 and H7N4, has raised concerns worldwide. During the winter of 2020-2021, five novel H7 low pathogenic AIVs (LPAIVs) containing different neuraminidase (NA) subtypes, including two H7N3, an H7N8, and two H7N9, were detected in wild bird feces in South Korea. Complete genome sequencing and phylogenetic analysis showed that the novel H7Nx AIVs were reassortants containing two gene segments (hemagglutinin (HA) and matrix) that were related to the zoonotic Jiangsu-Cambodian H7 viruses causing zoonotic infection and six gene segments originating from LPAIVs circulating in migratory birds in Eurasia. A genomic constellation analysis demonstrated that all H7 isolates contained a mix of gene segments from different viruses, indicating that multiple reassortment occurred. The well-known mammalian adaptive substitution (E627K and D701N) in PB2 was not detected in any of these isolates. The detection of multiple reassortant H7Nx AIVs in wild birds highlights the need for intensive surveillance in both wild birds and poultry in Eurasia. | Lee, Yu-Na; Lee, Dong-Hun; Kwon, Jung-Hoon; Shin, Jae-In; Hong, Seo Yun; Cha, Ra Mi; Baek, Yoon-Gi; Lee, Eun-Kyoung; Sagong, Mingeun; Heo, Gyeong-Beum; Lee, Kwang-Nyeong; Lee, Youn-Jeong | Anim & Plant Quarantine Agcy, Avian Influenza Res & Diagnost Div, 177 Hyeoksin 8 Ro, Gimcheon Si 39660, Gyeongsangbuk D, South Korea; Univ Connecticut, Dept Pathobiol & Vet Sci, 61 North Eagleville Rd,Unit 3089, Storrs, CT 06269 USA; Kyungpook Natl Univ, Coll Vet Med, 80 Daehak Ro, Daegu 41566, South Korea | Lee, Dong-hun/H-5082-2019 | 59858247700; 55554985200; 55559800200; 57222738224; 57226691914; 57194199657; 57211667015; 25938359000; 57205461615; 57189089623; 35285884300; 55533095600 | ynlee27@korea.kr;dong-hunlee@uconn.edu;junghoon.kwon@knu.ac.kr;sji6951@naver.com;yuuunnn0116@gmail.com;rami.cha01@korea.kr;bygttaggg@gmail.com;ensenble@korea.kr;sagongmg@korea.kr;imheo@korea.kr;leekwn@korea.kr;leeyj700@korea.kr; | VIRUSES-BASEL | VIRUSES-BASEL | 1999-4915 | 13 | 11 | SCIE | VIROLOGY | 2021 | 5.818 | 36.5 | 0.16 | 2025-07-30 | 2 | 2 | avian influenza virus; H7; reassortant; phylogenetic analysis; wild bird | EPIDEMIOLOGY | Avian influenza virus; H7; Phylogenetic analysis; Reassortant; Wild bird | Animals; Animals, Wild; Birds; Hemagglutinin Glycoproteins, Influenza Virus; Influenza A Virus, H7N3 Subtype; Influenza A Virus, H7N9 Subtype; Influenza in Birds; Phylogeny; Republic of Korea; hemagglutinin; virus RNA; Influenza virus hemagglutinin; amino acid sequence; Article; bioinformatics; DNA sequence; gene sequence; gene structure; genetic reassortment; genotype; geographic distribution; Influenza A virus (H7N3); low pathogenic avian influenza virus; migrant bird; molecular epidemiology; nonhuman; phylogenetic tree; polymerase chain reaction; prevalence; sequence alignment; sequence analysis; virus detection; virus isolation; whole genome sequencing; winter; zoonosis; animal; avian influenza; bird; genetics; Influenza A virus (H7N3); Influenza A virus (H7N9); isolation and purification; pathogenicity; phylogeny; South Korea; virology; wild animal | English | 2021 | 2021-11 | 10.3390/v13112274 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Genomic Analysis of Avian Infectious Bronchitis Viruses Recently Isolated in South Korea Reveals Multiple Introductions of GI-19 Lineage (QX Genotype) | Infectious bronchitis virus (IBV) was first identified in the 1930s and it imposes a major economic burden on the poultry industry. In particular, GI-19 lineage has spread globally and has evolved constantly since it was first detected in China. In this study, we analyzed S1 gene sequences from 60 IBVs isolated in South Korea. Two IBV lineages, GI-15 and GI-19, were identified in South Korea. Phylogenetic analysis suggested that there were six distinct subgroups (KM91-like, K40/09-like, and QX-like I to IV) of the South Korean GI-19 IBVs. Among them, QX-type III and IV subgroups, which are phylogenetically different from those reported in South Korea in the past, accounted for more than half of the total. Moreover, the phylogeographic analysis of the QX-like subgroups indicated at least four distinct introductions of GI-19 IBVs into South Korea during 2001-2020. The efficacy of commercialized vaccines against the recently introduced QX-like subgroups should be verified, and continuous international surveillance efforts and quarantine procedures should be enhanced to prevent the incursion of viruses. | Lee, Hyuk-Chae; Jeong, Sol; Cho, Andrew Y.; Kim, Kyu-Jik; Kim, Jun-Young; Park, Dam-Hee; Kim, Hyun-Jin; Kwon, Jung-Hoon; Song, Chang-Seon | Konkuk Univ, Coll Vet Med, 120 Neungdong Ro, Seoul 05029, South Korea; Kyungpook Natl Univ, Coll Vet Med, 80 Daehak Ro, Daegu 41566, South Korea | ; Song, Chang-Seon/D-7282-2011 | 57223640663; 57077551800; 57211355010; 57194497292; 57218494918; 57221303661; 57224361997; 55559800200; 55555239800 | big4103@gmail.com;soljeong492@gmail.com;7rewcho@gmail.com;zidanov31@gmail.com;okddr11@gmail.com;pdh03079@gmail.com;scv1188@gmail.com;Junghoon.kwon@knu.ac.kr;songcs@konkuk.ac.kr; | VIRUSES-BASEL | VIRUSES-BASEL | 1999-4915 | 13 | 6 | SCIE | VIROLOGY | 2021 | 5.818 | 36.5 | 1.1 | 2025-07-30 | 16 | 16 | IBV; avian coronavirus; surveillance; South Korea; multiple introductions; phylogenetic inference | PHYLOGENETIC ANALYSIS; GENETIC DIVERSITY; CORONAVIRUSES; POULTRY; VACCINE | Avian coronavirus; IBV; Multiple introductions; Phylogenetic inference; South Korea; Surveillance | Animals; Chickens; Coronavirus Infections; Genomics; Genotype; Infectious bronchitis virus; Phylogeny; Poultry Diseases; Republic of Korea; Sequence Analysis, RNA; Sequence Homology; Spike Glycoprotein, Coronavirus; coronavirus spike glycoprotein; amino acid sequence; amnion fluid; Article; avian infectious bronchitis; Avian infectious bronchitis virus; continuous time Markov chain; gene; gene sequence; genotype; GI 15 lineage; GI 19 lineage; K40/09 like; KM91 like; maximum likelihood method; molecular epidemiology; nonhuman; nucleotide sequence; phylogenetic tree; phylogeny; phylogeography; poultry; QX like I; QX like II; QX like III; QX like IV; real time reverse transcription polymerase chain reaction; RNA extraction; S1 gene; Sanger sequencing; sequence analysis; South Korea; virus isolation; virus strain; animal; Avian infectious bronchitis virus; bird disease; chicken; classification; Coronavirus infection; genetics; genomics; genotype; isolation and purification; sequence homology; veterinary medicine; virology | English | 2021 | 2021-06 | 10.3390/v13061045 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Multiple Human Papilloma Virus (HPV) Infections Are Associated with HSIL and Persistent HPV Infection Status in Korean Patients | Infections with multiple human papilloma virus (HPV) types have been reported, but their role in cervical carcinogenesis has not been fully elucidated. In this study, 236 cases with multiple HPV infection were examined and compared to 180 cases with single HPV infection. HPV genotyping was performed with cervico-vaginal swab specimens using multiplex (real-time) polymerase chain reaction (PCR). In multiple HPV infection, the most prevalent HPV genotype was HPV 53, followed by HPV 16, 58, 52, and 68. HPV 33, 35, 39, 51, 52, 53, 58, and 68 were high-risk-HPV (HR-HPV) genotypes that were more frequently detected in multiple HPV infection compared to that in single HPV infection. The association between multiple HPV infection and high-grade SIL (HSIL) was significantly stronger compared to that of single HPV infection and HSIL (p = 0.002). Patients with multiple HPV infection displayed persistent and longer duration of the HPV infection compared to patients with single HPV infection. Multiple HPV infections have distinct clinicopathologic characteristics. Since it is associated with persistent HPV infection, HSIL, and different HR-HPV strains in contrast to single HPV infection, the presence of multiple HPV infection should be reported; close follow up is warranted. | Kim, Moonsik; Park, Nora Jee-Young; Jeong, Ji Yun; Park, Ji Young | Kyungpook Natl Univ, Chilgok Hosp, Dept Pathol, Sch Med, Daegu 41566, South Korea | 57195918515; 57226185359; 57205472984; 57210160197 | teiroa83@knuh.kr;pathpjy@naver.com;jjiyun@gmail.com;jyparkmd@knu.ac.kr; | VIRUSES-BASEL | VIRUSES-BASEL | 1999-4915 | 13 | 7 | SCIE | VIROLOGY | 2021 | 5.818 | 36.5 | 3.93 | 2025-07-30 | 57 | 59 | HPV; multiple infection; HPV genotype; cervical neoplasia | INVASIVE CERVICAL-CANCER; HIGH-GRADE; RISK; LESIONS; PREVALENCE; COINFECTION; SINGLE; IMPACT | Cervical neoplasia; HPV; HPV genotype; Multiple infection | Adolescent; Adult; Aged; Aged, 80 and over; Alphapapillomavirus; Cervical Intraepithelial Neoplasia; Cervix Uteri; Coinfection; DNA, Viral; Female; Genotype; Humans; Middle Aged; Papillomaviridae; Papillomavirus Infections; Republic of Korea; Uterine Cervical Neoplasms; virus DNA; adolescent; adult; aged; Alphapapillomavirus; coinfection; female; genetics; genotype; human; middle aged; Papillomaviridae; papillomavirus infection; pathogenicity; South Korea; uterine cervix; uterine cervix carcinoma in situ; uterine cervix tumor; very elderly; virology | English | 2021 | 2021-07 | 10.3390/v13071342 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Subclinical Infection and Transmission of Clade 2.3.4.4 H5N6 Highly Pathogenic Avian Influenza Virus in Mandarin Duck (Aix galericulata) and Domestic Pigeon (Columbia livia domestica) | Since 2014, H5Nx clade 2.3.4.4 highly pathogenic avian influenza viruses (HPAIV) have caused outbreaks in wild birds and poultry in multiple continents, including Asia, Europe, Africa, and North America. Wild birds were suspected to be the sources of the local and global spreads of HPAIV. This study evaluated the infectivity, pathogenicity, and transmissibility of clade 2.3.4.4 H5N6 HPAIV in mandarin ducks (Aix galericulata) and domestic pigeons (Columbia livia domestica). None of the birds used in this study, 20 mandarin ducks or 8 pigeons, showed clinical signs or mortality due to H5N6 HPAI infection. Two genotypes of H5N6 HPAIV showed replication and transmission by direct and indirect contact between mandarin ducks. H5N6 HPAIV replicated and transmitted by direct contact between pigeons, although the viral shedding titer and duration were relatively lower and shorter than those in mandarin ducks. Influenza virus antigen was detected in various internal organs of infected mandarin ducks and pigeons, indicating systemic infection. Therefore, our results indicate mandarin ducks and pigeons can be subclinically infected with clade 2.3.4.4 H5N6 HPAIV and transfer the virus to adjacent birds. The role of mandarin ducks and pigeons in the spread and prevalence of clade 2.3.4.4 H5N6 viruses should be carefully monitored. | Jeong, Sol; Kwon, Jung-Hoon; Lee, Sun-Hak; Kim, Yu-Jin; Jeong, Jei-Hyun; Park, Jung-Eun; Jheong, Weon-Hwa; Lee, Dong-Hun; Song, Chang-Seon | Konkuk Univ, Coll Vet Med, Avian Dis Lab, Seoul 05029, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Microbiol, Daegu 41566, South Korea; Natl Inst Wildlife Dis Control & Prevent, Wildlife Dis Response Team, Gwangju 62407, South Korea; Univ Connecticut, Dept Pathobiol & Vet Sci, Storrs, CT 06269 USA | ; Lee, Dong-hun/H-5082-2019; Song, Chang-Seon/D-7282-2011 | 57077551800; 55559800200; 57201463694; 56344443200; 57077501100; 57191622467; 24076289900; 55554985200; 55555239800 | soljeong492@gmail.com;junghoon.kwon@knu.ac.kr;cnescis@naver.com;yujinml@hanmail.net;nar21ss@hanmail.net;jepark87.11@gmail.com;purify@korea.kr;dong-hun.lee@uconn.edu;songcs@konkuk.ac.kr; | VIRUSES-BASEL | VIRUSES-BASEL | 1999-4915 | 13 | 6 | SCIE | VIROLOGY | 2021 | 5.818 | 36.5 | 0.63 | 2025-07-30 | 10 | 11 | highly pathogenic avian influenza; clade 2; 3; 4; 4; pathogenicity; wild bird; mandarin duck; pigeon | TIME RT-PCR; WILD BIRDS; SOUTH-KOREA; A VIRUS; A(H5N8) VIRUS; SUSCEPTIBILITY; EVOLUTION; OUTBREAKS; EPIDEMIOLOGY; WATERFOWL | Clade 2.3.4.4; H5N6; Highly pathogenic avian influenza; Mandarin duck; Pathogenicity; Pigeon; Wild bird | Animals; Animals, Wild; Asymptomatic Infections; Columbidae; Disease Outbreaks; Ducks; Genotype; Influenza A virus; Influenza in Birds; Phylogeny; Poultry; Poultry Diseases; Virus Replication; Virus Shedding; phosphate buffered saline; Aix galericulata; animal experiment; Article; asymptomatic infection; avian influenza virus; biosafety; domestic pigeon; duck; enzyme linked immunosorbent assay; genotype; hemagglutination inhibition; immunohistochemistry; Influenza virus; limit of detection; mortality; nonhuman; pathogenicity; prevalence; quantitative analysis; real time polymerase chain reaction; reverse transcription polymerase chain reaction; seroconversion; serology; virus infectivity; virus load; virus neutralization; virus shedding; virus titration; virus transmission; animal; asymptomatic infection; avian influenza; bird disease; blood; classification; Columbidae; epidemic; genetics; Influenza A virus; pathogenicity; phylogeny; poultry; veterinary medicine; virology; virus replication; wild animal | English | 2021 | 2021-06 | 10.3390/v13061069 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effect of stress diffusion on the Oldroyd-B fluid flow past a confined cylinder | For the Oldroyd-B fluid flow past a cylinder, it has been well known that converged solutions for the stress in the wake downstream of the cylinder cannot be obtained when the Weissenberg number exceeds 0.7. This has been an unresolved problem [M.A. Alves, P.J. Oliveira and F.T. Pinho, Annu. Rev. Fluid Mech., 53:509-41, 2021]. This problem has various origins, such as the validity of numerical methods and the constitutive equation. This study examines the relationship between the convergence with respect to mesh refinement and the thermodynamically modified Oldroyd-B fluid, which has a diffusion term. We show that stress diffusion is thermodynamically natural and contributes to the convergence of the numerical solution for the Oldroyd-B fluid flow past a cylinder. Stress diffusion has typically been neglected because of its small value, although it is inherent to real polymers. The diffusion term does not change the flow behavior significantly but facilitates the determination of a mesh converged stress solution for the Weissenberg number up to 0.8. This result cannot be obtained from the original Oldroyd-B model. It is thus revealed that the diffusion term can effectively stabilize the stress in the region of steep stress gradients. | Lee, Junghaeng; Hwang, Wook Ryol; Cho, Kwang Soo | Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu, South Korea; Gyeongsang Natl Univ, Sch Mech Engn, Res Ctr Aircraft Parts Technol ReCAPT, Gajwa Dong 900, Jinju, South Korea | 57198781113; 10641313400; 56316379300 | wrhwang@gnu.ac.kr;polphy@knu.ac.kr; | JOURNAL OF NON-NEWTONIAN FLUID MECHANICS | J NON-NEWTON FLUID | 0377-0257 | 1873-2631 | 297 | SCIE | MECHANICS | 2021 | 3.112 | 36.6 | 0.74 | 2025-07-30 | 12 | 12 | Stress diffusion; Finite element method; Flow a past confined cylinder; Viscoelastic flow simulation | FINITE-ELEMENT METHODS; VISCOELASTIC FLOW; INTERNAL VARIABLES; NONEQUILIBRIUM THERMODYNAMICS; NUMERICAL-SIMULATION; DYNAMICS; COMPUTATIONS; RHEOLOGY; NUMBER | Finite element method; Flow a past confined cylinder; Stress diffusion; Viscoelastic flow simulation | Cylinders (shapes); Diffusion in liquids; Mesh generation; Numerical methods; Confined cylinder; Effect of stress; Mesh refinement; Numerical solution; Oldroyd-b models; Stress diffusion; Stress solutions; Weissenberg number; Flow of fluids | English | 2021 | 2021-11 | 10.1016/j.jnnfm.2021.104650 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Influence of fin orientation on the natural convection of aqueous-based nano-encapsulated PCMs in a heat exchanger equipped with wing-like fins | The heat transfer enhancement in pin-fin heat exchangers is achieved by fluid mixing, disruption of the thermal viscous boundary and the extension of the effective surface area for maximum heat exchange. The orientation and configuration of the fins are among the prime factors influencing the performance of these heat exchangers. Therefore, the present study investigates the combined influences of fin angle (0 <= zeta <= 270), arrangement and position of the wing-like fins on the natural convection of aqueous-based nano-encapsulated phase change material (PCM) in a fin heat exchanger. The analysis is performed for Rayleigh and Stefan numbers of 1e3-1e5 and 0.2 respectively by considering the PCM concentration of 0.05. The flow is assumed to be laminar, incompressible and Newtonian. The results demonstrate that the vertical alignment of the fins contributes to the augmentation of the thermal performance compared to the horizontally arranged fins. At the larger Rayleigh number, the mode of heat transfer is predominantly convective and thermal performance slightly deteriorates due to the blockage caused by adjacent fins. For low Rayleigh number, the conduction is the primary mode of heat transfer between the source and sink fins. This phenomenon is crucial to determine the heat exchanger thermal performance. | Shehzad, S. A.; Alshuraiaan, Bader; Kamel, Mohammed Saad; Izadi, Mohsen; Ambreen, Tehmina | COMSATS Univ Islamabad, Dept Math, Sahiwal 57000, Pakistan; Kuwait Univ, Dept Mech Engn, POB 5969, Kuwait 13060, Kuwait; Southern Tech Univ, Al Nasiriya Tech Inst, Dept Mech Tech, Thi Qar 64001, Iraq; Lorestan Univ, Fac Engn, Dept Mech Engn, Khorramabad, Iran; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | ; Izadi, Mohsen/D-3783-2018; Kamel, Mohammed/M-6636-2017; Shehzad, Sabir/J-3885-2014 | 42262831200; 56008129700; 57203018415; 55948220800; 57195420431 | izadi.m@lu.ac.ir; | CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION | CHEM ENG PROCESS | 0255-2701 | 1873-3204 | 160 | SCIE | ENERGY & FUELS;ENGINEERING, CHEMICAL | 2021 | 4.264 | 36.7 | 4.28 | 2025-07-30 | 71 | 75 | Natural convection; Nano-encapsulated PCM; Wing-like fins; heat source-sink; numerical solutions | THERMAL-ENERGY STORAGE; CHANGE MATERIAL SLURRY; TRANSFER ENHANCEMENT; CIRCULAR TUBE; PERFORMANCE; SINK; WAVY | heat source-sink; Nano-encapsulated PCM; Natural convection; numerical solutions; Wing-like fins | Fins (heat exchange); Natural convection; Phase change materials; Effective surface area; Encapsulated phase change materials; Heat Transfer enhancement; Pin-fin heat exchanger; Source and sink; Thermal Performance; Vertical alignment; Viscous boundary; Heat transfer performance | English | 2021 | 2021-03 | 10.1016/j.cep.2020.108287 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Dynamin-related protein 1 positively regulates osteoclast differentiation and bone loss | Dynamin-related protein 1 (DRP1) is a mitochondrial membrane GTPase and regulates mitochondrial fission. In this study, we found that the cytokine RANKL increased the expression of DRP1 and its receptor proteins, Fis1, Mid49, and Mid 51, during osteoclast formation in mouse bone marrow-derived macrophages. Inactivation of the kinase GSK3 beta appeared to induce DRP1 expression. DRP1 knockdown or the DRP1 inhibitor Mdivi1 suppressed osteoclast differentiation via downregulation of c-Fos and NFATc1, the key transcription factor for osteoclast formation. Finally, the DRP1 inhibitor suppressed lipopolysaccharide-induced osteoclast formation in a calvarial model and ovariectomy-induced bone loss in vivo. Taken together, our data demonstrate that DRP1 positively contributes to RANKL-induced osteoclast differentiation by regulating the c-Fos-NFATc1 axis, suggesting the importance of mitochondrial DRP1 in osteoclastogenesis. | Jeong, Sol; Seong, Ji Hye; Kang, Ju-Hee; Lee, Dong-Seok; Yim, Mijung | Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Daegu, South Korea | Kim, Se-Ho/IUP-3256-2023 | 57220077740; 57220068942; 56434883500; 57210068061; 57203258150 | myim@sookmyung.ac.kr; | FEBS LETTERS | FEBS LETT | 0014-5793 | 1873-3468 | 595 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS;CELL BIOLOGY | 2021 | 3.864 | 36.8 | 1.04 | 2025-07-30 | 24 | 19 | bone loss; DRP1; NFATc1; osteoclastogenesis; RANKL | MITOCHONDRIAL DYNAMICS; C-FOS; LIGAND; RANKL; ACTIVATION | bone loss; DRP1; NFATc1; osteoclastogenesis; RANKL | Animals; Cell Differentiation; Dynamins; Male; Mice; Mice, Inbred ICR; Osteoclasts; Osteogenesis; Osteoporosis; RANK Ligand; dynamin I; glycogen synthase kinase 3beta; lipopolysaccharide; osteoclast differentiation factor; protein c fos; protein Fis1; protein Mid 51; protein Mid49; protein NFATc1; receptor protein; small interfering RNA; transcription factor NFAT; unclassified drug; Dnm1l protein, mouse; dynamin; osteoclast differentiation factor; Tnfsf11 protein, mouse; animal cell; animal experiment; animal model; animal tissue; Article; bone marrow derived macrophage; cell culture; cell differentiation; cell migration; cell proliferation assay; controlled study; down regulation; DRP1 gene; enzyme inactivation; enzyme regulation; gene repression; genetic transduction; genetic transfection; immunoblotting; immunoprecipitation; in vivo study; male; mouse; nonhuman; osteoclast; osteoclastogenesis; osteolysis; ovariectomy; priority journal; protein expression; protein function; staining; animal; bone development; cell differentiation; cytology; Institute for Cancer Research mouse; osteoclast; osteoporosis; pathophysiology; physiology | English | 2021 | 2021-01 | 10.1002/1873-3468.13963 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Effects of M2O3 (M = Bi, Al) on silver vanadate glass for radioactive iodine immobilization | This study investigated the effects of Bi2O3 and Al2O3 on silver vanadate glasses for iodine immobilization. An iodine immobilization matrix was developed and examined with M2O3 (M = Bi, Al) as additives for a AgI-Ag2O-V2O5 glass system. Immobilization was confirmed at 800 degrees C after 1 h of melting without significant loss of the elements that constituted the glass, excluding aluminum. The loading of iodine in the matrix was approximately 30-36% by weight, excluding oxygen. Normalized releases of all elements obtained were below the order of 10(-1) g/m(2), which satisfies the USA regulation (2 g/m(2)). The structural factors that influenced the chemical durability of the glass and suppressed iodine release were discussed. The addition of M2O3 (M = Bi, Al) suppressed iodine release by the formation of a VO4 tetrahedron from the V2O5 glass matrix. The release of silver was not as suppressed as that of iodine. (C) 2021 Elsevier Ltd. All rights reserved. | Kang, Hyun Woo; Choi, Jung-Hoon; Lee, Ki Rak; Park, Hwan-Seo; Lee, Byeonggwan; Eom, Hyeon Jin | Korea Atom Energy Res Inst, Daedoek Daero 989-111, Daejeon 34057, South Korea; Kyungpook Natl Univ, Daehak Ro 80, Daegu 41566, South Korea | Lee, Byeonggwan/HPD-2363-2023 | 55128039500; 56227488100; 14420116600; 56175751900; 57201269846; 57222569272 | hyunwookang@kaeri.re.kr; | ANNALS OF NUCLEAR ENERGY | ANN NUCL ENERGY | 0306-4549 | 1873-2100 | 157 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2021 | 1.81 | 36.8 | 0.41 | 2025-07-30 | 4 | 4 | Iodine immobilization; Radioactive iodine; Silver vanadate glass; Vitrification; Sequestration | VISIBLE-LIGHT IRRADIATION; SPRAY-PYROLYSIS; H-2 EVOLUTION; CONDUCTIVITY | Iodine immobilization; Radioactive iodine; Sequestration; Silver vanadate glass; Vitrification | Additives; Alumina; Aluminum oxide; Bismuth compounds; Iodine; Radioactivity; Silver; Silver halides; Silver oxides; Vanadium pentoxide; Ag$++$; Bi$-2$/O$-3$; Immobilization matrices; Iodine immobilizations; Radioactive iodine; Sequestration; Silver vanadate glass; Silver vanadates; V$-2$/O$-5$; Vanadate glass; Glass | English | 2021 | 2021-07 | 10.1016/j.anucene.2021.108259 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Effects on pool boiling critical heat flux (CHF) with different direction and magnitude of additional accelerations due to rolling | The effects of boiling behaviors and critical heat flux (CHF) under rolling motion were investigated using different directions and magnitude of additional accelerations. The rolling conditions are amplitudes of 10 degrees and 30 degrees and periods of 10 s and 20 s. Vapor behaviors and CHF were opposite between the heated surface placed above and below the rolling axis. When the heated surface was placed above the rolling axis, the centrifugal acceleration acts away from the heated surface, pulling the vapor to detach. However, the centrifugal acceleration acts toward the heated surface when the heated surface was placed below the rolling axis, increasing vapor attachment to the heated surface. By placing the heated surface above the rolling axis, CHF enhanced approximately by 31% and were reduced to approximately 23% compared to when the heated surface was placed below the rolling axis as the platform rolls faster and slower, respectively. (C) 2020 Elsevier Ltd. All rights reserved. | Tanjung, Elvira F.; Kim, Byoung Jae; Jo, Daeseong | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea; Chungnam Natl Univ, Sch Mech Engn, 99 Daehak Ro, Daejeon 34134, South Korea | Kim, Seonghwan/AAZ-1679-2021 | 57202612180; 58163399200; 16424303000 | djo@knu.ac.kr; | ANNALS OF NUCLEAR ENERGY | ANN NUCL ENERGY | 0306-4549 | 1873-2100 | 154 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2021 | 1.81 | 36.8 | 0.81 | 2025-07-30 | 7 | 8 | Additional acceleration; Rolling motion; CHF mechanism; Vapor behaviors; Pool boiling | BUBBLE BEHAVIORS; FLOW; CHANNEL; WATER; REACTOR | Additional acceleration; CHF mechanism; Pool boiling; Rolling motion; Vapor behaviors | Centrifugation; Centrifugal acceleration; Critical heat flux(CHF); Heated surfaces; Pool boiling; Rolling conditions; Rolling motion; Heat flux | English | 2021 | 2021-05 | 10.1016/j.anucene.2020.108095 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Experimental study of critical heat flux mechanism on a vertical heated surface under rolling motion | Experiments were performed to understand the critical heat flux (CHF) mechanism on a vertical heated surface under rolling motion. The maximum rolling amplitude and periods were set to 30 degrees and 10 and 30 s, respectively. Because of the rolling motion, there are two additional accelerations on the working fluid: centrifugal and tangential. When the platform rolled clockwise or counter-clockwise, combination of tangential acceleration and inclined surface has significant effects on boiling. When the platform rolled faster, early CHF occurred at a higher tangential acceleration. Boiling behaviors on the heated surface under the rolling conditions were compared with those under static conditions. Under static conditions, early CHF occurred at -30 degrees inclination angle as the heated surface faced downward. Boiling behavior at -30 degrees inclination angle under static condition was similar to that under rolling motion when the rolling platform rolled counter-clockwise at the angle between -23 degrees and -27 degrees, where CHF occurs. (C) 2020 Elsevier Ltd. All rights reserved. | Albdour, Samah A.; Tanjung, Elvira F.; Jo, Daeseong | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 702701, South Korea | ALBDOUR, SAMAH/AAR-9857-2021 | 57205234242; 57202612180; 16424303000 | djo@knu.ac.kr; | ANNALS OF NUCLEAR ENERGY | ANN NUCL ENERGY | 0306-4549 | 151 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2021 | 1.81 | 36.8 | 0.31 | 2025-07-30 | 2 | 3 | Critical heat flux; Rolling motion; Pool boiling; Vertical heated surface | Critical heat flux; Pool boiling; Rolling motion; Vertical heated surface | Clocks; Counter-clockwise; Critical heat flux(CHF); Heated surfaces; Inclination angles; Inclined surface; Rolling conditions; Rolling motion; Static conditions; Heat flux | English | 2021 | 2021-02 | 10.1016/j.anucene.2020.107967 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | FU-Net: fast biomedical image segmentation model based on bottleneck convolution layers | Recently, the introduction of Convolutional Neural Network (CNNs) has advanced the way of solving image segmentation tasks. Semantic image segmentation has considerably benefited from employing various CNN models. The most widely used network in this field is U-Net and its different variations. However, these models require significant number of trainable parameters, floating-point operations per second, and great computational power to be trained. These factors make real-time semantic segmentation in low powered devices very hard. Therefore, in the present paper, we aim to modify particular aspects of the U-Net model to improve its performance through developing a fast U-Net (FU-Net) relying on bottleneck convolution layers in the contraction and expansion paths of the model. The proposed model can be utilized in semantic segmentation applications even on the devices with limited computational power and memory by ensuring the state-of-the-art performance. The amount of memory required by the proposed model is reduced by 23 times when compared with the original U-Net. Moreover, the modifications allowed achieving better performance. In conducted experiments, we assessed the performance of the proposed model on two biomedical image segmentation datasets, namely 2018 Data Science Bowl and ICIS 2018: Skin Lesion Analysis Towards Melanoma Detection. FU-Net demonstrated the state-of-the-art results in biomedical image segmentation, requiring the number of trainable parameters reduced by eight times compared with the original U-Net model. In addition, using bottleneck layers decreased the number of computations, resulting in nearly 30% speed-up at the training, validation and test stages. Furthermore, despite relying on fewer parameters FU-Net achieved a slight improvement of the performance in terms of pixel accuracy, Jaccard index, and dice coefficient evaluation metrics. | Olimov, Bekhzod; Sanjar, Karshiev; Din, Sadia; Ahmad, Awaise; Paul, Anand; Kim, Jeonghong | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | ; Din, Sadia/ADU-4679-2022; Olimov, Bekhzod/AAA-9362-2021; Paul, Anand/V-6724-2017 | 57220579660; 57210910507; 57188997144; 57224336715; 56650522400; 55138548100 | bekhzod.olimov@gmail.com;sanikarshiev@gmail.com;saadia.deen@gmail.com;awais.ahmad@live.com;paul.editor@gmail.com;jhk@knu.ac.kr; | MULTIMEDIA SYSTEMS | MULTIMEDIA SYST | 0942-4962 | 1432-1882 | 27 | 4 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;COMPUTER SCIENCE, THEORY & METHODS | 2021 | 2.603 | 36.8 | 4.99 | 2025-07-30 | 32 | 31 | Biomedical image segmentation; Bottleneck convolution layers; Batch normalization; U-Net; CNN | RECOGNITION | Batch normalization; Biomedical image segmentation; Bottleneck convolution layers; CNN; U-Net | Convolution; Convolutional neural networks; Data Science; Dermatology; Digital arithmetic; Semantics; Biomedical image segmentation; Computational power; Contraction and expansion; Floating point operations per seconds; Low-powered devices; Semantic image segmentations; Semantic segmentation; State-of-the-art performance; Image segmentation | English | 2021 | 2021-08 | 10.1007/s00530-020-00726-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Human fibroblast-derived extracellular vesicles promote hair growth in cultured human hair follicles | Hair loss is a prevalent medical condition affecting both genders. In this study, we investigate the effects of a specific class of extracellular vesicles (EVs), namely human normal fibroblast-derived EVs (hFB-EVs), on human dermal papilla (DP) and outer root sheath (ORS) cells and examine the molecular mechanisms responsible for hair growth in hair follicles (HFs). We find that Wnt3a, which maintains the hair-generating activity of DP cells, is enriched and more strongly associated with hFB-EVs than with fibroblasts. Furthermore, hFB-EV-associated Wnt3a mediated receptor activation in cultured DP cells, leading to an increase in beta-catenin in the cytoplasm and its translocation into the nucleus, thereby elevating expression of the target genes Axin2 and Lef1. Additionally, hFB-EVs promoted the migration, proliferation, and differentiation of ORS cells and elongation of the hair shaft in human HFs. These findings revealed a novel mechanism by which hFB-EVs influence hair growth. | Rajendran, Ramya Lakshmi; Gangadaran, Prakash; Kwack, Mi Hee; Oh, Ji Min; Hong, Chae Moon; Sung, Young Kwan; Lee, Jaetae; Ahn, Byeong-Cheol | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, BK21 FOUR KNU Convergence Educ Program Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu, South Korea | ; Gangadaran, Prakash/AAV-3102-2021; Rajendran, Ramya/AAV-6338-2021; Lee, Jaetae/AAR-3317-2021 | 57195318729; 54393130400; 6507685557; 57190370462; 37050876700; 55663365300; 7601451907; 7202791511 | abc2000@knu.ac.kr; | FEBS LETTERS | FEBS LETT | 0014-5793 | 1873-3468 | 595 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOPHYSICS;CELL BIOLOGY | 2021 | 3.864 | 36.8 | 0.97 | 2025-07-30 | 17 | 17 | extracellular vesicles; hair follicle; outer root sheath cell; Wnt/beta-catenin signaling | SMOOTH MUSCLE ACTIN; ROOT SHEATH-CELLS; EXOSOMES; RECEPTORS | extracellular vesicles; hair follicle; outer root sheath cell; Wnt/β-catenin signaling | Axin Protein; beta Catenin; Cell Differentiation; Cell Proliferation; Cells, Cultured; Extracellular Vesicles; Fibroblasts; Hair Follicle; Humans; Lymphoid Enhancer-Binding Factor 1; Wnt Proteins; Wnt Signaling Pathway; beta catenin; Wnt3a protein; axin; AXIN2 protein, human; CTNNB1 protein, human; LEF1 protein, human; lymphoid enhancer factor 1; Wnt protein; Article; Axin2 gene; cell culture; cell differentiation; cell migration; cell nucleus; cell proliferation; cellular distribution; controlled study; cytoplasm; exosome; fibroblast; fibroblast cell line; fibroblast culture; gene; gene expression; hair; hair follicle; hair growth; hair root; human; human cell; human normal fibroblast derived extracellular vesicle; Lef1 gene; outer root sheath cell; papillary dermis; cell culture; exosome; fibroblast; genetics; growth, development and aging; hair follicle; metabolism; Wnt signaling | English | 2021 | 2021-04 | 10.1002/1873-3468.14050 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Post-neutron mass yield distribution in the thermal neutron induced fission of ²³⁸Pu | The cumulative and independent yields of various fission products within the mass range of 83-155 have been measured in the thermal neutron induced fission of Pu-238 by using an off-line c-ray spectrometric technique. From the cumulative yields, post-neutron mass chain yields were obtained by using the charge distribution correction. From the mass yields data, the full width at tenth maximum (FWTM) of light and heavy mass wing, the average light mass () and heavy mass () as well as the average number of neutrons () emitted were obtained. The mass yield data in the Pu-238(n(th), f) reaction was compared with the similar data of Pu-241(n(th), f) reaction to examine the nuclear structure effect. (C) 2021 Elsevier Ltd. All rights reserved. | Naik, H.; Dange, S. P.; Singh, R. J.; Jang, W. | Bhabha Atom Res Ctr, Radiochem Div, Mumbai 400085, Maharashtra, India; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea | 7005890232; 6602557752; 24322531600; 59777352500 | naikhbarc@yahoo.com; | ANNALS OF NUCLEAR ENERGY | ANN NUCL ENERGY | 0306-4549 | 1873-2100 | 162 | SCIE | NUCLEAR SCIENCE & TECHNOLOGY | 2021 | 1.81 | 36.8 | 0.71 | 2025-07-30 | 7 | 7 | Pu-238(nf) reaction; E-n=0.025 eV; Measured fission product yields; Mass chain yield distribution; Off-line c-ray spectrometric technique | CHARGE-DISTRIBUTION | <sup>238</sup>Pu(nf) reaction; E<sub>n</sub>= 0.025 eV; Mass chain yield distribution; Measured fission product yields; Off-line γ–ray spectrometric technique | Fission products; Fission reactions; Gamma rays; 238pu(nf) reaction; Average numbers; En= 0.025 ev; Mass chain yield distribution; Measured fission product yield; Neutron-induced fission; Off-line γ–ray spectrometric technique; Similar datum; Spectrometric techniques; Thermal neutrons; Neutrons | English | 2021 | 2021-11 | 10.1016/j.anucene.2021.108493 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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