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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Immune Response Kinetics Following a Third Heterologous BNT162b2 Booster Dose After Primary 2-Dose ChAdOx1 Vaccination in Relation to Omicron Breakthrough Infection: A Prospective Nationwide Cohort Study in South Korea Background Immune responses to each vaccine must be investigated to establish effective vaccination strategies for the ongoing coronavirus disease (COVID-19) pandemic. We investigated the long-term kinetics of immune responses after heterologous booster vaccination in relation to Omicron breakthrough infection (BI). Methods Our study included 373 healthcare workers who received primary ChAdOx1 vaccine doses and a third BNT162b2 vaccine dose. BIs that occurred after the third vaccine were investigated. Blood specimens were collected before and 3 months after the booster dose from participants without BI and 1, 4, and 6 months after BI from participants who experienced BI. Spike-specific binding and neutralizing antibody levels against the wild-type virus, Omicron BA.1, and Omicron BA.5, as well as cellular responses, were analyzed. Results A total of 346 participants (82 in the no BI group; 192 in the BI group during the BA.1/BA.2 period; 72 in the BI group during the BA.5 period) were included in the analysis. Participants without BI exhibited the highest binding and neutralizing antibody concentrations and greatest cellular response 1 month after the third vaccination, which reached a nadir by the ninth month. Antibody and cellular responses in participants who experienced BI substantially increased postinfection. Neutralizing antibody titers in individuals who experienced BI during the BA.1/BA.2 period showed more robust increase against wild-type virus than against BA.1 and BA.5. Conclusions Our findings provide evidence of antigenic imprinting in participants who received a heterologous booster vaccination, thereby serving as a foundation for further studies on the impact of BIs on immune responses. Ahn, Jin Young; Ko, Jae-Hoon; Peck, Kyong Ran; Bae, Seongman; Kim, Sung-Han; Lee, Kyoung Hwa; Song, Young Goo; Kim, Yong Chan; Park, Yoon Soo; Song, Kyoung-Ho; Kim, Eu Suk; Jeong, Hye Won; Kim, Shin-Woo; Kwon, Ki Tae; Choi, Won Suk; Choi, Jun Yong Yonsei Univ, Severance Hosp, Dept Internal Med, Coll Med,Div Infect Dis, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Div Infect Dis,Dept Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Infect Dis, Seoul, South Korea; Yonsei Univ, Gangnam Severance Hosp, Coll Med, Div Infect Dis,Dept Internal Med, Seoul, South Korea; Yonsei Univ, Yongin Severance Hosp, Coll Med, Div Infect Dis,Dept Internal Med, Yongin, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, Seongnam, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Korea Univ, Ansan Hosp, Coll Med, Div Infect Dis,Dept Internal Med, Ansan, South Korea; Yonsei Univ, Yonsei Univ Hlth Syst, Dept Internal Med, Coll Med,Div Infect Dis, 50-1 Yonsei Ro, Seoul 03722, South Korea; Korea Univ, Ansan Hosp, Dept Internal Med, Coll Med,Div Infect Dis, 123 Jeokgeum Ro, Ansan 15355, South Korea Choi, Jah/AAA-4835-2022; Kim, Hanjin/KYP-2633-2024; KIM, SUNG/ADF-8559-2022; Choi, Won Suk/V-2730-2017; Park, Yoon/C-6472-2015; Peck, Kyong Ran/AGV-5205-2022; Lee, Kyoung-Hwa/AAJ-5213-2021; Choi, Won/V-2730-2017; Jeong, Hye/AET-1982-2022; Kim, Ik-Sang/J-5425-2012 57225850337; 55804188300; 55664295200; 57189690904; 55133790400; 56955948100; 55675198500; 36486497700; 7405373036; 23398486700; 22938086900; 13103042700; 8710731500; 9733850500; 56718971800; 57791298700 cmcws@korea.ac.kr;seran@yuhs.ac; OPEN FORUM INFECTIOUS DISEASES OPEN FORUM INFECT DI 2328-8957 10 7 SCIE IMMUNOLOGY;INFECTIOUS DISEASES;MICROBIOLOGY 2023 3.8 25.4 1.06 2025-06-25 6 6 COVID-19; antigen imprinting; coronavirus disease; heterologous booster vaccination; Omicron breakthrough infection antigen imprinting; coronavirus disease; COVID-19; heterologous booster vaccination; Omicron breakthrough infection gamma interferon; paracetamol; riltozinameran; tozinameran; vaxzevria; adult; antibody blood level; antibody response; antibody titer; arthralgia; Article; asthma; blood sampling; breakthrough infection; chill; cohort analysis; coronavirus disease 2019; diabetes mellitus; diarrhea; dyslipidemia; enzyme linked immunosorbent assay; fatigue; female; headache; health care personnel; human; hypertension; immune response; injection site pain; injection site swelling; kinetics; male; multicenter study; myalgia; pandemic; polymerase chain reaction; prospective study; retrospective study; revaccination; rheumatic disease; SARS-CoV-2 Omicron; seroconversion; serology; skin redness; South Korea; thyroid disease; vaccination; virus nucleocapsid; vomiting English 2023 2023-07-01 10.1093/ofid/ofad363 바로가기 바로가기 바로가기 바로가기
Article Multiple Hepatic Lipoma: A Case Report of Captive Hill Mynah with Iron Storage Disease Simple Summary The lipoma is a benign tumor consisting of mature adipocytes. Although lipomas can arise anywhere on the body, hepatic lipomas are rarely observed; thus, only a few hepatic lipoma cases are documented in veterinary medicine. According to previous research, the majority of hepatic lipomas are generally observed as solitary nodular structures. However, recently, multiple hepatic lipomas were found in a captive hill mynah. In the present case, the liver tissue from the bird exhibited not only multiple hepatic lipomas, but also excessive iron accumulation. To the best knowledge of the authors, this is the first report of multiple hepatic lipomas accompanying ISD, and herein, these unique pathological findings are reported.Abstract The present case describes multiple hepatic lipomas in a common hill mynah (Gracula religiosa). A 21-year-old female captive common hill mynah died without any notable clinical symptoms. An autopsy and histopathological examinations were conducted to determine the exact cause of death. On gross observation, the liver demonstrated a yellowish white surface color and multiple nodules indicating neoplastic lesions. Histopathological assessment found that the nodules purely comprised mature adipocytes. Furthermore, the liver exhibited an excessive accumulation of iron in hepatocytes and Kupffer cells and the infiltration of chronic inflammatory cells, suggesting iron storage disease (ISD). Based on the results, the present case was diagnosed as multiple hepatic lipomas with ISD. To the authors' best knowledge, multiple hepatic lipomas accompanying ISD lesions have not been reported previously. Hence, the present case is the first case report of hepatic multiple lipomas with ISD in veterinary medicine. Lee, Seoungw-Woo; Youn, Soong-Hee; Park, Jin-Kyu Kyungpook Natl Univ, Coll Vet Med, Dept Vet Pathol, Daegu 41566, South Korea; DGIST, Div Biotechnol, Daegu 42988, South Korea; Samsung Everland Zool Garden, Yongin 17023, South Korea 57218827581; 55876632700; 35213723500 pyrk2000@dgist.ac.kr;hapysh3@naver.com;jinkyu820@knu.ac.kr; VETERINARY SCIENCES VET SCI 2306-7381 10 10 SCIE VETERINARY SCIENCES 2023 2 25.4 0 2025-06-25 0 0 captive animal; hill mynah; iron storage disease; lipoma FAT-CONTAINING LESIONS; LIVER; MYELOLIPOMAS; METABOLISM; DIAGNOSIS captive animal; hill mynah; iron storage disease; lipoma adipocyte; angiomyolipoma; animal experiment; animal model; animal tissue; anorexia; Article; blood biochemistry; cell infiltration; controlled study; differential diagnosis; female; hemosiderosis; histopathology; iron blood level; Kupffer cell; lipoma; liver cell; liver fatty degeneration; liver parenchyma; male; Masson staining; nonhuman; prussian blue staining; veterinary medicine English 2023 2023-10 10.3390/vetsci10100626 바로가기 바로가기 바로가기 바로가기
Article 1,5-Anhydro-D-glucitol derivative and galloylated flavonoids isolated from the leaves of Acer ginnala Maxim. as dual inhibitors of PTP1B and α-glucosidase enzymes: In vitro and in silico studies Four undescribed compounds (two 1,5-anhydro-D-glucitol derivatives and two galloyl derivatives) and fourteen known compounds were isolated and structurally identified from leaves of Acer ginnala Maxim. (Amur maple). Structures and absolute configurations of the four undescribed compounds were determined using extensive analysis of NMR spectroscopic, HRESI-MS, modified Mosher ester method, and comparison with spectroscopic data of known compounds. Bioactivity evaluation revealed that the isolated 1,5-anhydro-D-glucitol derivative, galloylated flavonol rhamnosides, and galloylated flavanols had inhibitory effects on both protein tyrosine phosphatase-1B (PTP1B, IC50 values ranging of 3.46-12.65 mu M) and alpha-glucosidase (IC50 values ranging of 0.88-6.06 mu M) in comparison with a positive control for PTP1B (ursolic acid, IC50 = 5.10 mu M) or alpha-glucosidase (acarbose, IC50 = 141.62 mu M). A combination of enzyme kinetic analysis and molecular docking provided additional evidence in favor of their inhibitory activities and mechanism. These data demonstrate that A. ginnala Maxim. together with its constituents are promising sources of potent candidates for developing novel anti-diabetic medications. Le, Thi Thanh; Ha, Manh Tuan; Cao, Thao Quyen; Kim, Jeong Ah; Choi, Jae Sue; Min, Byung Sun Daegu Catholic Univ, Coll Pharm, Drug Res & Dev Ctr, Daegu 38430, Gyeongbuk, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Food & Life Sci, Pusan 48513, South Korea ; Tuan, Ha/AAW-5444-2021; Quyen, Cao/AAP-9678-2020 57350699400; 57189040434; 56937820500; 24722570900; 57698194000; 55663638200 Lethanha1k33@gmail.com;bsmin@cu.ac.kr; PHYTOCHEMISTRY PHYTOCHEMISTRY 0031-9422 1873-3700 213 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;PLANT SCIENCES 2023 3.2 25.5 1.62 2025-06-25 10 10 Acer ginnala; Aceraceae; Amur maple; Glucitol; Galloylated flavonoid; PTP1B; alpha-Glucosidase; Anti-diabetes GLYCOSIDES; QUERCETIN; MAPLE Acer ginnala; Aceraceae; Amur maple; Anti-diabetes; Galloylated flavonoid; Glucitol; PTP1B; α-Glucosidase Acer; alpha-Glucosidases; Enzyme Inhibitors; Flavonoids; Glycoside Hydrolase Inhibitors; Kinetics; Molecular Docking Simulation; Plant Leaves; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Sorbitol; 1,5-anhydroglucitol; alpha glucosidase; enzyme inhibitor; flavonoid; glycosidase inhibitor; protein tyrosine phosphatase 1B; sorbitol; Acer; chemistry; kinetics; metabolism; molecular docking; plant leaf English 2023 2023-09 10.1016/j.phytochem.2023.113769 바로가기 바로가기 바로가기 바로가기
Review Advances and Challenges of Sensing in Water Using CRISPR-Cas Technology The groundbreaking gene-editing mechanism, CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), paired with the protein Cas9, has significantly advanced the realms of biology, medicine, and agriculture. Through its precision in modifying genetic sequences, CRISPR holds the potential to alter the trajectory of genetic disorders and accelerate advancements in agriculture. While its therapeutic potential is profound, the technology also invites ethical debates centered on responsible use and equity in access. Parallelly, in the environmental monitoring sphere and sensing in water, especially biosensors have been instrumental in evaluating natural water sources’ quality. These biosensors, integrating biological components with detection techniques, have the potential to revolutionize healthcare by providing rapid and minimally invasive diagnostic methods. However, the design and application of these sensors bring forth challenges, especially in ensuring sensitivity, selectivity, and ethical data handling. This article delves into the prospective use of CRISPR-Cas technology for sensing in water, exploring its capabilities in detecting diverse biomarkers, hazardous substances, and varied reactions in water and wastewater systems. © 2024 American Chemical Society. Safarkhani, Moein; Farasati Far, Bahareh; Kim, Su-Hyeon; Makvandi, Pooyan; Park, Mi-Kyung; Huh, YunSuk; Rabiee, Navid Department of Biological Sciences and Bioengineering, Nano Bio High-Tech Materials Research Center, Inha University, Incheon, 22212, South Korea; Department of Chemistry, Iran University of Science and Technology, Tehran, 16844, Iran; School of Food Science and Biotechnology, Kyungpook National University, Daegu, 41566, South Korea; The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Zhejiang, Quzhou, 324000, China; School of Food Science and Biotechnology, Kyungpook National University, Daegu, 41566, South Korea; Department of Biological Sciences and Bioengineering, Nano Bio High-Tech Materials Research Center, Inha University, Incheon, 22212, South Korea; Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, 6150, WA, Australia 57205147040; 59341629000; 57217051011; 56732944400; 7404491155; 8425039200; 57201008317 yunsuk.huh@inha.ac.kr;nrabiee94@gmail.com; ACS Biomaterials Science and Engineering ACS BIOMATER SCI ENG 2373-9878 2373-9878 SCIE MATERIALS SCIENCE, BIOMATERIALS 2023 5.5 25.5 0.14 2025-06-25 3 biosensor; CRISPR-Cas; environmental science; point-of-care; sensor English Article in press 2023 10.1021/acsbiomaterials.3c01689 바로가기 바로가기 바로가기
Article Diterpene and biflavone derivatives from Thuja koraiensis and their cytotoxicities against A549 cells During the screening of the cytotoxicity of rare Korean endemic plants, the extract of Thuja koraiensis Nakai displayed potent cytotoxicity against the adenocarcinomic human alveolar basal epithelial A549 cell line. Through a series of separations via column chromatography, three undescribed abietanes, an undescribed lab-dane along with a labdane, and a biflavonoid were purified from methylene chloride (CH2Cl2) fraction possessing a potent cytotoxic effect. Extensive 1D and 2D NMR spectroscopic data analyses, in combination with quantum chemical calculations were conducted to establish the planar and absolute configurations of thujakoraienes A-C. The chemical structure of thujakoraiene D was elucidated by spectroscopic data analysis and competing enan-tioselective acylation. Thujakoraienes A and C along with 7,7 ''-di-O-methylamentoflavone, showed cytotoxic effects on A549 cells, with IC50 values of 64.86, 47.97, and 16.14 mu M, respectively. Finally, thujakoraiene C and 7,7 ''-di-O-methylamentoflavone were identified as potent cytotoxic compounds in A549 cells, followed by an additional cytotoxicity test in the normal human lung fibroblast MRC-5 cell line. This is the first study on the non-volatile chemicals in the extract of T. koraiensis and comparison of chemical profiles of T. orientalis and T. koraiensis. Kim, Geum Jin; Yang, Eun-Ju; Kim, Young Sung; Moon, Jimin; Son, Youn Kyoung; Nam, Joo-Won; Choi, Inho; Choi, Hyukjae; Song, Kyung-Sik Yeungnam Univ, Coll Pharm, 280 Daehak ro, Gyongsan 38541, Gyeongbuk, South Korea; Yeungnam Univ, Res Inst Cell Culture, 280 Daehak ro, Gyongsan 38541, Gyeongbuk, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, 80 Daehak ro, Daegu 41566, South Korea; Natl Inst Biol Resources, Biol & Genet Resources Assessment Div, 42, Hwangyeong ro, Incheon 22689, South Korea; Yeungnam Univ, Dept Med Biotechnol, 280 Daehak ro, Gyongsan 38541, Gyeongbuk, South Korea 54585532800; 57191204368; 58235614800; 57273609200; 8903186200; 8883246800; 56406839400; 7404339587; 13310139000 h5choi@yu.ac.kr;kssong@knu.ac.kr; PHYTOCHEMISTRY PHYTOCHEMISTRY 0031-9422 1873-3700 211 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;PLANT SCIENCES 2023 3.2 25.5 0.16 2025-06-25 2 1 Thuja koraiensis Nakai; Cupressaceae; Diterpene; Biflavonoid; ECD calculation; A549; Cytotoxicity; Lactate dehydrogenase assay ESSENTIAL OIL; ORIENTALIS; CONSTITUENTS; CHEMOTHERAPY; FLAVONOIDS; LEAVES A549; Biflavonoid; Cupressaceae; Cytotoxicity; Diterpene; ECD calculation; Lactate dehydrogenase assay; Thuja koraiensis Nakai A549 Cells; Antineoplastic Agents; Cell Line, Tumor; Diterpenes; Humans; Molecular Structure; Plant Extracts; Thuja; antineoplastic agent; diterpenoid; plant extract; A-549 cell line; chemical structure; chemistry; human; Thuja; tumor cell line English 2023 2023-07 10.1016/j.phytochem.2023.113711 바로가기 바로가기 바로가기 바로가기
Article Encapsulation of bacteria in bilayer Pluronic thin film hydrogels: A safe format for engineered living materials In engineered living materials (ELMs) non-living matrices encapsulate microorganisms to acquire capabilities like sensing or biosynthesis. The confinement of the organisms to the matrix and the prevention of overgrowth and escape during the lifetime of the material is necessary for the application of ELMs into real devices. In this study, a bilayer thin film hydrogel of Pluronic F127 and Pluronic F127 acrylate polymers supported on a solid substrate is introduced. The inner hydrogel layer contains genetically engineered bacteria and supports their growth, while the outer layer acts as an envelope and does not allow leakage of the living organisms outside of the film for at least 15 days. Due to the flat and transparent nature of the construct, the thin layer is suited for microscopy and spectroscopy-based analyses. The composition and properties of the inner and outer layer are adjusted independently to fulfil viability and confinement requirements. We demonstrate that bacterial growth and light-induced protein production are possible in the inner layer and their extent is influenced by the crosslinking degree of the used hydrogel. Bacteria inside the hydrogel are viable long term, they can act as lactate-sensors and remain active after storage in phosphate buffer at room temperature for at least 3 weeks. The versatility of bilayer bacteria thin-films is attractive for fundamental studies and for the development of application-oriented ELMs. Bhusari, Shardul; Kim, Juhyun; Polizzi, Karen; Sankaran, Shrikrishnan; del Campo, Aranzazu INM Leibniz Inst New Mat, Saarbrucken, Germany; Saarland Univ, Chem Dept, D-66123 Saarbrucken, Germany; Imperial Coll London, Dept Chem Engn, London SW7 2AZ, England; Imperial Coll London, Imperial Coll Ctr Synthet Biol, London SW7 2AZ, England; Kyungpook Natl Univ, Sch Life Sci, FOUR KNU Creat Biores Grp BK21, Daegu 41566, South Korea; INM Leibniz Inst New Mat, Campus D2, D-66123 Saarbrucken, Germany Sankaran, Shrikrishnan/U-4335-2019 57204710776; 55829164000; 10039266100; 56200865600; 57210740155 shrikrishnan.sankaran@leibniz-inm.de;aranzazu.delcampo@leibniz-inm.de; BIOMATERIALS ADVANCES BIOMATER ADV 2772-9508 145 SCIE MATERIALS SCIENCE, BIOMATERIALS 2023 5.5 25.5 2.61 2025-06-25 23 23 Engineered living material; Bacterial hydrogel; Biosensor; Bacteria-materials interactions; Living therapeutics; Biocontainment Bacteria-materials interactions; Bacterial hydrogel; Biocontainment; Biosensor; Engineered living material; Living therapeutics Bacteria; Hydrogels; Poloxamer; Polymers; Biochemistry; Buffer storage; Hydrogels; Thin films; hydrogel; poloxamer; polymer; Bacteria-material interaction; Bacterial hydrogel; Bi-layer; Biocontainment; Engineered living material; Living therapeutic; Material interactions; matrix; Pluronics; Thin-films; bacterium; chemistry; Bacteria English 2023 2023-02 10.1016/j.bioadv.2022.213240 바로가기 바로가기 바로가기 바로가기
Article Immune Checkpoint-Blocking Nanocages Cross the Blood-Brain Barrier and Impede Brain Tumor Growth Glioblastoma (GBM) is the deadliest tumor of the central nervous system, with a median survival of less than 15 months. Despite many trials, immune checkpoint-blocking (ICB) therapies using monoclonal antibodies against the PD-1/PD-L1 axis have demonstrated only limited benefits for GBM patients. Currently, the main hurdles in brain tumor therapy include limited drug delivery across the blood-brain barrier (BBB) and the profoundly immune-suppressive microenvironment of GBM. Thus, there is an urgent need for new therapeutics that can cross the BBB and target brain tumors to modulate the immune microenvironment. To this end, we developed an ICB strategy based on the BBB-permeable, 24-subunit human ferritin heavy chain, modifying the ferritin surface with 24 copies of PD-L1-blocking peptides to create ferritin-based ICB nanocages. The PD-L1pep ferritin nanocages first demonstrated their tumor-targeting and antitumor activities in an allograft colon cancer model. Next, we found that these PD-L1pep ferritin nanocages efficiently penetrated the BBB and targeted brain tumors through specific interactions with PD-L1, significantly inhibiting tumor growth in an orthotopic intracranial tumor model. The addition of PD-L1pep ferritin nanocages to triple in vitro cocultures of T cells, GBM cells, and glial cells significantly inhibited PD-1/PD-L1 interactions and restored T-cell activity. Collectively, these findings indicate that ferritin nanocages displaying PD-L1-blocking peptides can overcome the primary hurdle of brain tumor therapy and are, therefore, promising candidates for treating GBM. Kim, Minseong; Yoon, Hee Jung; Lee, Chanju; Lee, Minah; Park, Rang-Woon; Lee, Byungheon; Park, Eun Jung; Kim, Soyoun Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Plus KNU Biomed Convergence Program BK21,Dept Biom, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, CMRI, Daegu 41944, South Korea; Natl Canc Ctr, Grad Sch Canc Sci & Policy, Div Canc Biomed Sci, Immuno Oncol Branch, Goyang 10408, South Korea Park, Eun/W-1340-2019; Lee, Jong/A-3198-2011 ejpark@ncc.re.kr;soyounki@knu.ac.kr; ACS BIOMATERIALS SCIENCE & ENGINEERING ACS BIOMATER SCI ENG 2373-9878 10 1 SCIE MATERIALS SCIENCE, BIOMATERIALS 2023 5.5 25.5 5 glioblastoma; blood brainbarrier; PD-L1 bindingpeptide; immune checkpoint; ferritin; nanocage ANTI-PD-L1 ANTIBODY; FERRITIN; CANCER; GLIOBLASTOMA; DELIVERY; PD-L1; EXPRESSION; PLATFORM; SAFETY; PEMBROLIZUMAB English 2023 2023-12-27 10.1021/acsbiomaterials.3c01200 바로가기 바로가기 바로가기
Article Removal of Ni²⁺ and Zn²⁺ from groundwater by adsorption onto fishbone and hydroxyapatite: Effect of salinity Ni2+- and Zn2+-contaminated groundwater in the coastal regions is a serious threat to water security in industrial areas. Apatite-like material is an excellent sorbent for heavy metals; however the effect of salinity on the Ni2+ and Zn2+ adsorption onto fishbone and synthesized hydroxyapatite (HAP) has not been investigated. This study investigates the effect of salinity on the single and binary adsorption of Ni2+ and Zn2+ onto apatite-like materials. The experiments were conducted in batch reactor for 24 h at 1:40 solid-to-liquid ratios (wt/wt), 25 degrees C, and pH 5. Freundlich, Langmuir, and Dubinin-Radushkevich models fit well with the single-adsorption data. The adsorption isotherms were nonlinear (N-F = 0.350-0.710). The maximum adsorption capacities (q(mL)) of the Ni2+ and Zn2+ onto HAP were higher than those onto the fishbone, attributed to the higher Brunauer-Emmett-Teller surface area (A(BET)) and cation exchange capacity. In the binary adsorption, adsorption capacities of the adsorbents were less than those in the single-solute system due to the competition between Ni2+ and Zn2+. Salinity affected the single and binary adsorption by decreasing the adsorption capacities of the adsorbents. In a binary adsorption system, the selectivity of Zn2+ was less than that of Ni2+ for both fishbone and HAP at 0 parts per thousand and 30 parts per thousand salinity, respectively. Binary adsorption models, such as the Murali-Aylmore (M-A) model, competitive Langmuir model (CLM), P-factor model, and ideal-adsorbed solution theory coupled with the Freundlich (IAST-Freundlich) model were used; of these, the M-A model provided the best prediction for the binary system. Septian, Ardie; Choi, Jiyeon; Shin, Won Sik Natl Res & Innovat Agcy, Res Ctr Environm & Clean Technol, Badan Riset & Inovasi Nasl, BRIN, Serpong, Indonesia; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, 80 Daehakro, Daegu 41566, South Korea Septian, Ardie/HGB-8696-2022 57201503612; 57211707591; 23019870800 wshin@knu.ac.kr; ENERGY & ENVIRONMENT ENERG ENVIRON-UK 0958-305X 2048-4070 34 6 SSCI ENVIRONMENTAL STUDIES 2023 4 25.5 0.19 2025-06-25 3 2 binary adsorption; fishbone; hydroxyapatite; Ni2+; salinity; Zn2+ COMPETITIVE ADSORPTION; APATITE II(TM); SORPTION; METAL; WATER; ACID; CADMIUM; SINGLE; IONS; DYES binary adsorption; fishbone; hydroxyapatite; Ni<sup>2+</sup>; salinity; Zn<sup>2+</sup> Adsorption; Apatite; Batch reactors; Groundwater; Groundwater pollution; Heavy metals; Adsorption capacities; Binary adsorption; Coastal regions; Contaminated groundwater; Fishbone; Ni2+; Salinity; Single and binary adsorptions; Water security; Zn 2+; adsorption; apatite; bone; groundwater pollution; nickel; pollutant removal; salinity; zinc; Hydroxyapatite English 2023 2023-09 10.1177/0958305x221102048 바로가기 바로가기 바로가기 바로가기
Article Numerical investigations of translocation characteristics of non-spherical silica nanoparticles across pulmonary surfactant monolayer under different respiratory states using coarse-grained molecular dynamics method Understanding translocation characteristics of non-spherical silica nanoparticles (SiNPs) across pulmonary surfactant (PS) monolayer is of great significance for their applications in inhaled nanoparticles (NPs) drugs, as their shapes may impact drug delivery efficiency. Therefore, this study has performed coarse-grained molecular dynamics (CGMD) simulation to study the characteristics of SiNPs across the PS monolayer and adsorption of dipalmitoylphosphatidylcholine (DPPC) molecules. It is found that SiNPs smaller than 8 nm are more likely to cross the PS monolayer in expansion state than other states and crossing times required for ellipsoidal SiNPs are the shortest, and when SiNPs are in penetrating and embedding states, the number of DPPC molecules adsorbed by bulged-spherical SiNPs is the highest. In conclusion, ellipsoidal SiNPs have the strongest crossing ability and bulged-spherical SiNPs cause the greatest damage. Therefore, it is suggested to adopt ellipsoidal SiNPs and avoid bulged-spherical SiNPs when improving transportation efficiencies of spherical SiNP drug carriers. Tang, Kailiang; Ge, Haiwen; Choi, Sanghun; Xi, Zhaojun; Cui, Xinguang Huazhong Univ Sci & Technol, Sch Aerosp Engn, Wuhan, Hubei, Peoples R China; Zhejiang Lab, Hangzhou, Zhejiang, Peoples R China; Kyungpook Natl Univ, Daegu, South Korea ; Choi, Sanghun/AGS-7430-2022; Ge, Haiwen/R-1604-2018 58519481400; 14421143900; 55847101000; 57214328092; 50261346800 xinguang_cui@mail.hust.edu.cn; POWDER TECHNOLOGY POWDER TECHNOL 0032-5910 1873-328X 428 SCIE ENGINEERING, CHEMICAL 2023 4.5 25.6 0.46 2025-06-25 4 4 Non-spherical silica nanoparticles; Coarse-grained molecular dynamics simulation; Crossing pulmonary surfactant monolayer; Adsorbing dipalmitoylphosphatidylcholine SHAPE; DESIGN; MODEL Adsorbing dipalmitoylphosphatidylcholine; Coarse-grained molecular dynamics simulation; Crossing pulmonary surfactant monolayer; Non-spherical silica nanoparticles Drug delivery; Efficiency; Molecular dynamics; Molecules; Monolayers; Numerical methods; Phospholipids; Spheres; Surface active agents; dipalmitoylphosphatidylcholine; drug carrier; lung surfactant; silicon nanoparticle; Adsorbing dipalmitoylphosphatidylcholine; Coarse-grained molecular dynamics simulations; Crossing pulmonary surfactant monolayer; Dipalmitoyl phosphatidylcholine; Dipalmitoylphosphatidylcholine; Non-Spherical; Non-spherical silicum nanoparticle; Pulmonary surfactants; Silica nanoparticles; Spherical silica; Surfactant monolayers; adsorption; Article; controlled study; drug delivery system; embedding; molecular dynamics; morphology; particle size; respiratory function; simulation; Silica nanoparticles English 2023 2023-10-01 10.1016/j.powtec.2023.118851 바로가기 바로가기 바로가기 바로가기
Article Relationship between plasma dopamine concentration and temperament in horses Dopamine (DA) is a neurotransmitter associated with animal behaviors. Along with other neurotransmitters such as oxytocin (OXT) and serotonin (5-HT), DA is also involved in determining the temperament of animals. However, the involvement of DA in horse temperament has not been well elucidated. Therefore, in this study, we aimed to determine the correlation between plasma DA concentration and OXT and 5-HT concentrations and behavioral temperament (eg, docility and friendliness, fearfulness, dominance, and trainability) of horses. Blood samples were collected from 31 horses and the concentrations of DA, OXT, and 5-HT were measured using enzyme-linked immunosorbent assay. The temperament of horses was assessed and scored by 3 researchers. The correlation between the plasma concentration of DA and OXT or 5-HT was statistically analyzed using SPSS software and linear regression analysis was performed to determine the association between DA concentration and OXT and 5-HT concentrations. Meanwhile, the DA concentration associated with each type of temperament was analyzed via one-way analysis of variance with LSD post hoc analysis as well as Student's t -test (for trainability). Plasma DA concentration was not found to be correlated with either OXT or 5-HT concentrations. Furthermore, we found no correlation between plasma DA concentration and dominance and trainability. However, our results suggest the possibility of predicting the degree of fearfulness of horses using plasma DA concentrations. We conclude that plasma DA concentration has a potentiality to be used as a biomarker to predict the fearfulness of horses.(c) 2023 Elsevier Inc. All rights reserved. Kim, J.; Jung, H.; Yoon, M. Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea; Kyungpook Natl Univ, Res Ctr Horse Ind, Sangju 37224, South Korea 57218494918; 56374279800; 22137296500 mjyoonemail@gmail.com; DOMESTIC ANIMAL ENDOCRINOLOGY DOMEST ANIM ENDOCRIN 0739-7240 1879-0054 83 SCIE AGRICULTURE, DAIRY & ANIMAL SCIENCE;ENDOCRINOLOGY & METABOLISM 2023 1.9 25.6 1.05 2025-06-25 4 4 Horses; Dopamine; Temperament; Fearfulness; Dominance; Trainability CEREBROSPINAL-FLUID; SEROTONIN; OXYTOCIN; AGGRESSION; MICE Dominance; Dopamine; Fearfulness; Horses; Temperament; Trainability Animals; Behavior, Animal; Dopamine; Horses; Serotonin; Temperament; dopamine; lysergide; oxytocin; serotonin; dopamine; serotonin; animal behavior; animal experiment; animal tissue; Article; blood sampling; clinical assessment; concentration process; controlled study; correlation analysis; docility; dominance behavior; dopamine blood level; enzyme linked immunosorbent assay; fear; friend; horse; linear regression analysis; nonhuman; software; temperament; trainability; animal English 2023 2023-04 10.1016/j.domaniend.2023.106788 바로가기 바로가기 바로가기 바로가기
Article Characterizations of perfect fluid spacetimes obeying f(R)-gravity equipped with different gradient solitons The prime object of this paper is to study the perfect fluid spacetimes obeying f(R)-gravity, when eta-Ricci solitons, gradient eta-Ricci solitons, gradient Einstein solitons and gradient m-quasi Einstein solitons are its metrics. At first, the existence of the eta-Ricci solitons is proved by a non-trivial example. We establish conditions for which the eta-Ricci solitons are expanding, steady or shrinking. Besides, in the perfect fluid spacetimes obeying f(R)-gravity, when the potential vector field of eta-Ricci soliton is of gradient type, we acquire a Poisson equation. Moreover, we investigate gradient eta-Ricci solitons, gradient Einstein solitons and gradient m-quasi Einstein solitons in f(R)-gravity, respectively. As a result, we establish some significant theorems about dark matter era. De, Krishnendu; Suh, Young Jin; De, Uday Chand Univ Burdwan, Dept Math, Kabi Sukanta Mahavidyalaya, PO Angus Hooghly, Bhadreswar 712221, W Bengal, India; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, RIRCM, Daegu 41566, South Korea; Univ Calcutta, Dept Math, Kolkata, W Bengal, India De, Krishnendu/LWJ-4652-2024 55319393800; 57205268556; 7007046738 krishnendu.de@outlook.in;yjsuh@knu.ac.kr;uc_de@yahoo.com; INTERNATIONAL JOURNAL OF GEOMETRIC METHODS IN MODERN PHYSICS INT J GEOM METHODS M 0219-8878 1793-6977 20 10 SCIE PHYSICS, MATHEMATICAL 2023 2.1 25.8 0.74 2025-06-25 5 4 f(R)-gravity; perfect fluids; eta-Ricci solitons; Einstein solitons; m-quasi Einstein solitons RICCI SOLITONS; MANIFOLDS Einstein solitons; f (R) -gravity; m -quasi Einstein solitons; perfect fluids; η -Ricci solitons English 2023 2023-09-15 10.1142/s0219887823501748 바로가기 바로가기 바로가기 바로가기
Article Comparison of the efficacy of the early LI-SWT plus daily tadalafil with daily tadalafil only as penile rehabilitation for postprostatectomy erectile dysfunction This study compares the efficacy of the early low-intensity shock wave therapy (LI-SWT) plus daily tadalafil with daily tadalafil only therapy as penile rehabilitation for postprostatectomy erectile dysfunction in patients with prostate cancer who underwent bilateral interfascial nerve-sparing radical prostatectomy (robotic or open). From April 2019 to March 2021, 165 patients were enrolled, and 80 of them successfully completed this prospective study. Daily tadalafil were administered to all the patients. LI-SWT consisted of a total of six sessions. Each session was performed on days 4, 5, 6, and 7, and on the second and fourth weeks after surgery. Each LI-SWT session consisted of 300 shocks at an energy density of 0.09 mJ/mm(2) and a frequency of 120 shocks per minute that were delivered at each of the five treatment points for 15 min. Thirty-nine patients were treated with tadalafil-only (group A) while 41 were treated with tadalafil and LI-SWT simultaneously (group B). At postoperative 6 months, the proportion of patients with erection hardness scores (EHS) >= 3 (4/39 vs. 12/41) was significantly higher in group B (p = 0.034), and LI-SWT was the only independent factor for predicting EHS >= 3 (OR, 3.621; 95% CI, 1.054-12.437; p = 0.041). There were no serious side effects related to early LI-SWT. Early LI-SWT plus daily tadalafil therapy as penile rehabilitation for postprostatectomy erectile dysfunction is thought to be more efficacious than tadalafil only. Further large-scaled randomized controlled trials will be needed to validate these findings. Jang, Se Won; Lee, Eun Hye; Chun, So Young; Ha, Yun-Sok; Choi, Seock Hwan; Lee, Jun Nyung; Kim, Bum Soo; Kim, Hyun Tae; Kim, See Hyung; Kim, Tae-Hwan; Yoo, Eun Sang; Chung, Jae-Wook; Kwon, Tae Gyun Kyungpook Natl Univ Hosp, Dept Urol, Daegu, South Korea; Kyungpook Natl Univ, Biomed Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea Kim, Tae/B-9921-2013; Kim, Soo-Yeon/ADR-9663-2022; Kim, Young-Bo/AAR-8052-2021; Kim, Sang-Hyun/J-5402-2012 57428381500; 57189661699; 8688166900; 35487226400; 9742645500; 16301364600; 57202817150; 55739531300; 57216511386; 57797823600; 7006609239; 35204798500; 15073765400 jeus119@hanmail.net;tgkwon@knu.ac.kr; INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH INT J IMPOT RES 0955-9930 1476-5489 35 5 SCIE UROLOGY & NEPHROLOGY 2023 2.8 25.8 1.97 2025-06-25 9 8 EXTRACORPOREAL SHOCKWAVE THERAPY; SPARING RADICAL PROSTATECTOMY; CAVERNOUS NERVE INJURY; FUNCTION RECOVERY; WAVE THERAPY; DOUBLE-BLIND; DIAGNOSTIC-TOOL; MEN; TISSUE; RAT Erectile Dysfunction; Humans; Male; Penile Erection; Phosphodiesterase 5 Inhibitors; Prospective Studies; Prostatectomy; Tadalafil; Treatment Outcome; phosphodiesterase V inhibitor; tadalafil; phosphodiesterase V inhibitor; tadalafil; adult; aged; Article; bleeding tendency; body mass; controlled study; erectile dysfunction; follow up; hospitalization; human; International Index of Erectile Function; laparoscopy; major clinical study; male; prostate cancer; prostatectomy; questionnaire; shock wave therapy; erectile dysfunction; penis erection; prospective study; prostatectomy; treatment outcome English 2023 2023-08 10.1038/s41443-022-00560-w 바로가기 바로가기 바로가기 바로가기
Article Conformal vector field and gradient Einstein solitons on ?-Einstein cosymplectic manifolds In this paper, we characterize the ?-Einstein cosymplectic manifolds with the gradient Einstein solitons and the conformal vector fields. It is proven that if an ?-Einstein cosymplectic manifold M2n+1 of dimension 2n + 1 with n > 1 admits a gradient Einstein soliton, then either M2n+1 is Ricci flat or the gradient of Einstein potential function is pointwise collinear with the Reeb vector field of M2n+1. Also, we prove that if M2n+1 admits a conformal vector field W, then either M2n+1 is Ricci flat or W is homothetic. We also establish that a conformal vector field W on M2n+1 is a strict infinitesimal contact transformation, provided the scalar curvature of M2n+1 is constant. Finally, the non-trivial examples of cosymplectic manifolds admitting the gradient Einstein solitons are given. Chaubey, Sudhakar Kumar; De, Uday Chand; Suh, Young Jin Univ Technol & Appl Sci, Dept Informat Technol, Sect Math, POB 77, Shinas 324, Oman; Univ Calcutta, Dept Pure Math, 35 Ballygaunge Circular Rd, Kolkata 700019, West Bengal, India; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, RIRCM, Daegu 41566, South Korea Chaubey, S./ABB-6952-2021 36117508600; 7007046738; 7202260479 sudhakar.chaubey@shct.edu.om;uc_de@yahoo.com;yjsuh@knu.ac.kr; INTERNATIONAL JOURNAL OF GEOMETRIC METHODS IN MODERN PHYSICS INT J GEOM METHODS M 0219-8878 1793-6977 20 08 SCIE PHYSICS, MATHEMATICAL 2023 2.1 25.8 0.37 2025-06-25 0 2 Cosymplectic manifolds; gradient Einstein soliton; conformal vector field; homothetic vector field RICCI SOLITONS; CLASSIFICATION conformal vector field; Cosymplectic manifolds; gradient Einstein soliton; homothetic vector field English 2023 2023-07 10.1142/s0219887823501359 바로가기 바로가기 바로가기 바로가기
Erratum Correction: Comparison of the efficacy of the early LI-SWT plus daily tadalafil with daily tadalafil only as penile rehabilitation for postprostatectomy erectile dysfunction (International Journal of Impotence Research, (2023), 35, 5, (447-453), 10.1038/s41443-022-00560-w) Correction to: International Journal of Impotence Research , published online 28 March 2022 In this article the heading for table 4 should have read “Univariate and multivariate logistic regression models for predicting the erection hardness score ≥ 3 at 6 months post-operation.” The original article has been corrected. © 2022, The Author(s). Jang, Se Won; Lee, Eun Hye; Chun, So Young; Ha, Yun-Sok; Choi, Seock Hwan; Lee, Jun Nyung; Kim, Bum Soo; Kim, Hyun Tae; Kim, See Hyung; Kim, Tae-Hwan; Yoo, Eun Sang; Chung, Jae-Wook; Kwon, Tae Gyun Department of Urology, Kyungpook National University Hospital, Daegu, South Korea; Biomedical Research Institute, Kyungpook National University, Daegu, South Korea; Biomedical Research Institute, Kyungpook National University, Daegu, South Korea; Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea, Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu, South Korea; Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea, Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu, South Korea; Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Radiology, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea, Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu, South Korea; Department of Urology, School of Medicine, Kyungpook National University, Daegu, South Korea, Joint Institute for Regenerative Medicine, Kyungpook National University, Daegu, South Korea 57428381500; 57189661699; 8688166900; 35487226400; 9742645500; 16301364600; 57202817150; 55739531300; 57216511386; 57797823600; 7006609239; 35204798500; 15073765400 jeus119@hanmail.net;tgkwon@knu.ac.kr; International Journal of Impotence Research INT J IMPOT RES 0955-9930 1476-5489 35 5 SCIE UROLOGY & NEPHROLOGY 2023 2.8 25.8 0 2025-06-25 0 erratum English Final 2023 10.1038/s41443-022-00595-z 바로가기 바로가기 바로가기
Article N-formylation of amines with CO2 by using Zr-based metal-organic frameworks: Contribution of defect sites of MOFs to N-formylation N-formylation of amines (NFAs) like N-methylaniline and morpholine with CO2 was done under mild condition (0.1 MPa, 30 & DEG;C) in the presence of PhSiH3 as a reductant by using Zr-based MOFs like MOF-808 s (with various defect concentrations), UiO-66, and UiO-67. Preparing useful N-formamides from amines is one of the attractive ways to utilize CO2. The yield of N-methylformanilide from N-methylaniline linearly increased with increasing the defect concentration of MOF-808. Moreover, the performance of MOF-808(6), with the highest defect sites, decreased with the elimination of defects. Amorphized MOF-808(6), with increased defects, showed an impressive performance in NFAs, although the porosity decreased much upon amorphization. Therefore, defect sites had a dominant role in the NFAs, especially in the adsorption or activation of carbamate-like intermediates and silane. Moreover, defective MOF-808(6), prepared in one step (without any functionalization), might be a competitive/recyclable catalyst for NFAs, especially under mild conditions. Yoo, Dong Kyu; Jhung, Sung Hwa Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea Jhung, Sung/AAO-6683-2021 57201339246; 6701659467 sung@knu.ac.kr; APPLIED CATALYSIS A-GENERAL APPL CATAL A-GEN 0926-860X 1873-3875 659 SCIE CHEMISTRY, PHYSICAL;ENVIRONMENTAL SCIENCES 2023 4.7 25.8 1.52 2025-06-25 18 17 Carbon dioxide; Defect site; Metal -organic framework; N-formylation CARBON-DIOXIDE; CONVERSION; CATALYSIS; UIO-66; HYDROSILANE; CHEMICALS; CAPTURE; ACIDITY; DESIGN Carbon dioxide; Defect site; Metal-organic framework; N-formylation Amides; Amines; Defects; Organic polymers; Organometallics; Silicon; Silicon compounds; Zirconium compounds; Condition; Defect concentrations; Defect sites; Formylation; Formylation of amines; Metalorganic frameworks (MOFs); N-formylation; N-methylaniline; N-morpholine; Performance; Carbon dioxide English 2023 2023-06-05 10.1016/j.apcata.2023.119170 바로가기 바로가기 바로가기 바로가기
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Keywords (WoS) 저자가 논문에서 직접 지정한 키워드입니다. Web of Science에 등록된 저자 키워드 목록입니다.
KeywordsPlus (WoS) Web of Science에서 자동으로 추출한 추가 키워드입니다. 논문의 참고문헌 제목에서 자주 등장하는 단어들로 생성됩니다.
Keywords (SCOPUS) 저자가 논문에서 직접 지정한 키워드입니다. SCOPUS에 등록된 저자 키워드 목록입니다.
KeywordsPlus (SCOPUS) SCOPUS에서 자동으로 추출하거나 추가한 색인 키워드입니다.
Language 논문이 작성된 언어입니다. 대부분 English이며, 그 외 다양한 언어로 작성된 논문이 포함될 수 있습니다.
Publication Year 논문이 출판된 연도입니다.
Publication Date 논문의 정확한 출판 날짜입니다 (년-월-일 형식).
DOI Digital Object Identifier. 디지털 객체 식별자로, 논문을 고유하게 식별하는 영구적인 식별번호입니다. 이를 통해 논문의 온라인 위치를 찾을 수 있습니다.