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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Drug evaluation based on phosphomimetic PDHA1 reveals the complexity of activity-related cell death in A549 non-small cell lung cancer cells | Cancer cells predominantly generate energy via glycolysis, even in the presence of oxygen, to support abnormal cell proliferation. Suppression of PDHA1 by PDK1 prevents the conversion of cytoplasmic pyruvate into Acetyl-CoA. Several PDK inhibitors have been identified, but their clinical applications have not been successful for unclear reasons. In this study, endo-genous PDHA1 in A549 cells was silenced by the CRISPR/Cas9 system, and PDHA1(WT) and PDHA1(3SD) were transduced. Since PDHA1(3SD) cannot be phosphorylated by PDKs, it was used to evaluate the specific activity of PDK inhibitors. This study highlights that PDHA1(WT) and PDHA1(3SD) A549 cells can be used as a cell-based PDK inhibitor-distinction system to examine the relationship between PDH activity and cell death by established PDK inhibitors. Leelamine, huzhangoside A and otobaphenol induced PDH activity-dependent apoptosis, whereas AZD7545, VER-246608 and DCA effectively enhanced PDHA1 activity but little toxic to cancer cells. Furthermore, the activity of phosphomimetic PDHA1 revealed the complexity of its regulation, which requires further in-depth investigation. | Jin, Ling; Cho, Minkyoung; Kim, Bo-Sung; Han, Jung Ho; Park, Sungmi; Lee, In-Kyu; Ryu, Dongryeol; Kim, Jae Ho; Bae, Sung-Jin; Ha, Ki-Tae | Pusan Natl Univ, Dept Korean Med Sci, Sch Korean Med, Yangsan 50612, South Korea; Pusan Natl Univ, Korean Med Res Ctr Hlth Aging, Yangsan 50612, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41404, South Korea; Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon 16419, South Korea; Pusan Natl Univ, Coll Med, Dept Physiol, Yangsan 50612, South Korea | ; Kim, Jae/C-5549-2012; Kitae, Ha/AFW-2347-2022; Ryu, Dongryeol/C-5903-2008; Lee, In-Kyu/AAR-6374-2021; Kim, Byung Joo/ABG-7715-2021; Bae, Sung-Jin/AAX-9144-2021 | 57210844482; 59355724800; 57195515863; 57203488939; 56252420000; 36071537600; 57201809600; 35268883000; 57199938696; 7102262033 | Dr.NowOrNever@pusan.ac.kr;hagis@pusan.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 54 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 5.041 | 36.2 | 0.56 | 2025-07-30 | 9 | 10 | Apoptosis; Glycolysis; PDHA1; PDK; Warburg effect | PYRUVATE-DEHYDROGENASE KINASE; PHOSPHORYLATION SITES; INHIBITION; METABOLISM; AZD7545 | Apoptosis; Glycolysis; PDHA1; PDK; Warburg effect | A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Enzyme Inhibitors; Humans; Lung Neoplasms; Phosphorylation; Pyruvate Dehydrogenase (Lipoamide); enzyme inhibitor; pyruvate dehydrogenase; pyruvate dehydrogenase E1alpha subunit; A-549 cell line; apoptosis; chemistry; drug screening; enzymology; human; lung tumor; non small cell lung cancer; pathology; phosphorylation; procedures | English | 2021 | 2021-11-30 | 10.5483/bmbrep.2021.54.11.101 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Epac: new emerging cAMP-binding protein | The well-known second messenger cyclic adenosine monophosphate (cAMP) regulates the morphology and physiology of neurons and thus higher cognitive brain functions. The discovery of exchange protein activated by cAMP (Epac) as a guanine nucleotide exchange factor for Rap GTPases has shed light on protein kinase A (PKA)-independent functions of cAMP signaling in neural tissues. Studies of cAMP-Epac-mediated signaling in neurons under normal and disease conditions also revealed its diverse contributions to neurodevelopment, synaptic remodeling, and neurotransmitter release, as well as learning, memory, and emotion. In this mini-review, the various roles of Epac isoforms, including Epac1 and Epac2, highly expressed in neural tissues are summarized, and controversies or issues are highlighted that need to be resolved to uncover the critical functions of Epac in neural tissues and the potential for a new therapeutic target of mental disorders. | Lee, Kyungmin | Kyungpook Natl Univ, Lab Behav Neural Circuitry & Physiol, Dept Anat, Brain Sci & Engn Inst,Sch Med, Daegu 41944, South Korea | 57211016316 | irislkm@knu.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 54 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 5.041 | 36.2 | 1.82 | 2025-07-30 | 29 | 28 | Brain; Cognitive function; Epac; Neuron; Synapse | Brain; Cognitive function; Epac; Neuron; Synapse | Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Guanine Nucleotide Exchange Factors; Humans; cyclic AMP; cyclic AMP dependent protein kinase; guanine nucleotide exchange factor; RAPGEF3 protein, human; RAPGEF4 protein, human; animal; human; metabolism | English | 2021 | 2021-03-31 | 10.5483/bmbrep.2021.54.3.233 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Forebrain glutamatergic neuron-specific Ctcf deletion induces reactive microgliosis and astrogliosis with neuronal loss in adult mouse hippocampus | CCCTC-binding factor (CTCF), a zinc finger protein, is a transcription factor and regulator of chromatin structure. Forebrain excitatory neuron-specific CTCF deficiency contributes to inflammation via enhanced transcription of inflammation-related genes in the cortex and hippocampus. However, little is known about the long-term effect of CTCF deficiency on postnatal neurons, astrocytes, or microglia in the hippocampus of adult mice. To address this, we knocked out the Ctcf gene in forebrain glutamatergic neurons (Ctcf cKO) by crossing Ctcf-floxed mice with Camk2a-Cre mice and examined the hippocampi of 7.5-10-month-old male mice using immunofluorescence microscopy. We found obvious neuronal cell death and reactive gliosis in the hippocampal cornu ammonis (CA)1 in 7.5-10-month-old cKO mice. Prominent rod-shaped microglia that participate in immune surveillance were observed in the stratum pyramidale and radiatum layer, indicating a potential increase in inflammatory mediators released by hippocampal neurons. Although neuronal loss was not observed in CA3, and dentate gyrus (DG) CTCF depletion induced a significant increase in the number of microglia in the stratum oriens of CA3 and reactive microgliosis and astrogliosis in the molecular layer and hilus of the DG in 7.5-10-month-old cKO mice. These results suggest that long-term Ctcf deletion from forebrain excitatory neurons may contribute to reactive gliosis induced by neuronal damage and consequent neuronal loss in the hippocampal CA1, DG, and CA3 in sequence over 7 months of age. | Kwak, Ji-Hye; Lee, Kyungmin | Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Dept Anat,Lab Behav Neural Circuitry & Physiol, Daegu 41944, South Korea | Lee, Kyungmin/ABC-5624-2020 | 56689173300; 57211016316 | irislkm@knu.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 54 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 5.041 | 36.2 | 0.21 | 2025-07-30 | 3 | 3 | Astrogliosis; Ctcf; Hippocampus; Microgliosis; Neuronal death | CELL-DEATH; DIFFERENTIATION; MECHANISMS; EXPRESSION; MUTATIONS | Astrogliosis; Ctcf; Hippocampus; Microgliosis; Neuronal death | Animals; Astrocytes; CCCTC-Binding Factor; Cell Death; Gliosis; Glutamic Acid; Hippocampus; Male; Mice; Mice, Knockout; Microglia; Neurons; Prosencephalon; Ctcf protein, mouse; glutamic acid; transcription factor CTCF; animal; astrocyte; cell death; forebrain; gliosis; hippocampus; knockout mouse; male; metabolism; microglia; mouse; nerve cell; pathology; physiology | English | 2021 | 2021-06-30 | 10.5483/bmbrep.2021.54.6.265 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Gluconeogenic signals regulate hepcidin gene expression via a CRBN-KLF15 axis | Hepcidin (HAMP) is synthesized in the liver. It is a key iron-regulatory hormone that controls systemic iron homeostasis. Cereblon (CRBN) and Kruppel-like factor 15 (KLF15) are known to regulate diverse physiological functions. In this study, we investigated the role of CRBN on hepatic hepcidin gene expression and production under gluconeogenic stimuli. Fasted mice as well as forskolin (FSK)- and glucagon (GLU)-treated mice had reduced serum iron levels but increased expression levels of hepatic Crbn and Klf15 and hepcidin secretion. MicroRNA (miRNA) expression analysis of fasted and Ad-Crbn-infected mice revealed significant reduction of microRNA-639 (miR-639). Hepatic overexpression of Crbn elevated hepcidin expression and production along with Klf15 gene expression, whereas knockdown of Crbn and Klf15 markedly decreased FSK- and fasting-mediated induction of hepcidin gene expression and its biosynthesis in mouse livers and primary hepatocytes. Moreover, expression of KLF15 significantly increased the activity of hepcidin reporter gene. It was exclusively dependent on the KLF15-binding site identified within the hepcidin gene promoter. Overall, this study demonstrates that CRBN and KLF15 are novel mediators of gluconeogenic signal-induced hepcidin gene expression and production. Thus, CRBN and KLF15 might be novel potential therapeutic targets to intervene metabolic dysfunction. | Jo, Jeong-Rang; Lee, Sung-Eun; An, Seungwon; Nedumaran, Balachandar; Ghosh, Swati; Park, Keun-Gyu; Kim, Yong Deuk | Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41566, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA; Univ Colorado, Barbara Davis Ctr Diabet, Sch Med, Anschutz Med Campus, Aurora, CO 80045 USA; Univ Colorado, Dept Pediat, Sch Med, Anschutz Med Campus, Aurora, CO 80045 USA | Nedumaran, Balachandar/V-9958-2019 | 57223403375; 55890041600; 57208273554; 23976497500; 57201617635; 57202558343; 55549957700 | ydkim94@knu.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 54 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 5.041 | 36.2 | 0.28 | 2025-07-30 | 5 | 4 | Cereblon; Fasting; Gene expression; Hepcidin; Kruppel-like factor 15 | IRON HOMEOSTASIS; TARGETED DISRUPTION; SERUM IRON; CEREBLON; HEALTH | Cereblon; Fasting; Gene expression; Hepcidin; Kruppel-like factor 15 | Adaptor Proteins, Signal Transducing; Animals; Hepcidins; Kruppel-Like Transcription Factors; Mice; Crbn protein, mouse; hepcidin; Klf15 protein, mouse; kruppel like factor; signal transducing adaptor protein; animal; genetics; metabolism; mouse | English | 2021 | 2021-04-30 | 10.5483/bmbrep.2021.54.4.215 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Internal architecture and earthquake rupture behavior of a long-lived intraplate strike-slip fault: A case study from the Southern Yangsan Fault, Korea | Deciphering the internal composition of large-scale fault zones helps to better understand the various geologic factors that govern their seismic rupture behavior. We used new detailed geologic, structural, and geomorphic map of an excellent natural laboratory in the Southern Yangsan Fault (SYF) in the southeastern part of the Korean Peninsula to elucidate the fault zone architecture and its controls on the rupture processes of neotectonic earthquakes. The Yangsan Fault is a major strike-slip fault, and a subsidiary fault within the fault zone ruptured during the 2016 M-L 5.8 Gyeongju earthquake which is the largest instrumental record in the intraplate Korean Peninsula. The 12-km-long study area in the SYF shows along-strike variations in wall rock lithology and fault zone architecture. At the south of the study area, the fault zone surrounded by crystalline rocks consists of a single major fault core. In contrast, at the north, the fault zone is sandwiched between crystalline rocks and sedimentary rocks and exhibits multiple major fault cores bounding broken-up wall rock blocks. The width of the across-fault damage zone, which was estimated from the cumulative fracture frequency with the distance from the major fault core, widens northward, indicating the distributed deformation of the northern fault zone over a long history of fault evolution. The geometry of paleoearthquake surface ruptures traced by the geomorphic and stratigraphic evidence of deformed young deposits diverge to multiple strands in the northern fault zone but converge to a single strand in the southern fault zone, directly reflecting its internal architecture. We propose that the long-lived rupturing patterns have been primarily controlled by intrinsic discontinuity- and mineralogy-dependent deformation processes in terms of strain-hardening vs. strain-weakening, along with propagation arrest and rupture tip damage due to a fault-bend geometry (geometric barrier) and an abrupt change in wall rock lithology (relaxation barrier). | Kim, Namgwon; Park, Seung-Ik; Choi, Jin-Hyuck | Kyungpook Natl Univ, Sch Earth Syst Sci, Daegu 41566, South Korea; Korea Inst Geosci & Mineral Resources, Geol Div, Daejeon 34132, South Korea | 57218556086; 55832472000; 55511963900 | psi@knu.ac.kr;cjh9521@kigam.re.kr; | TECTONOPHYSICS | TECTONOPHYSICS | 0040-1951 | 1879-3266 | 816 | SCIE | GEOCHEMISTRY & GEOPHYSICS | 2021 | 3.66 | 36.2 | 1.44 | 2025-07-30 | 19 | 17 | Fault zone architecture; Paleoearthquake rupture; Deformation localization and distribution; Strain hardening; Rupture tip damage | FRICTIONAL-PROPERTIES; PUNCHBOWL FAULT; MECHANICAL-PROPERTIES; TECTONIC IMPLICATION; SE KOREA; ZONE; DEFORMATION; GOUGE; EVOLUTION; PERMEABILITY | Deformation localization and distribution; Fault zone architecture; Paleoearthquake rupture; Rupture tip damage; Strain hardening | Korea; Architecture; Crystalline rocks; Deformation; Earthquakes; Geometry; Lithology; Minerals; Process control; Sedimentary rocks; Strain hardening; Stratigraphy; Structural geology; Deformation process; Distributed deformation; Earthquake rupture; Fault zone architecture; Fracture frequency; Internal architecture; Internal composition; Natural laboratories; deformation; earthquake damage; earthquake rupture; fault zone; intraplate process; paleoseismicity; strain analysis; strike-slip fault; Fault slips | English | 2021 | 2021-10-05 | 10.1016/j.tecto.2021.229006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Odorant G protein-coupled receptors as potential therapeutic targets for adult diffuse gliomas: a systematic analysis and review | Odorant receptors (ORs) account for about 60% of all human G protein-coupled receptors (GPCRs). OR expression outside of the nose has functions distinct from odor perception, and may contribute to the pathogenesis of disorders including brain diseases and cancers. Glioma is the most common adult malignant brain tumor and requires novel therapeutic strategies to improve clinical outcomes. Here, we outlined the expression of brain ORs and investigated OR expression levels in glioma. Although most ORs were not ubiquitously expressed in gliomas, a subset of ORs displayed glioma subtype-specific expression. Moreover, through systematic survival analysis on OR genes, OR51E1 (mouse Olfr558) was identified as a potential biomarker of unfavorable overall survival, and OR2C1 (mouse Olfr15) was identified as a potential biomarker of favorable overall survival in isocitrate dehydrogenase (IDH) wild-type glioma. In addition to transcriptomic analysis, mutational profiles revealed that somatic mutations in OR genes were detected in > 60% of glioma samples. OR5D18 (mouse Olfr1155) was the most frequently mutated OR gene, and OR5AR1 (mouse Olfr1019) showed IDH wild-type-specific mutation. Based on this systematic analysis and review of the genomic and transcriptomic profiles of ORs in glioma, we suggest that ORs are potential biomarkers and therapeutic targets for glioma. | Cho, Hee Jin; Koo, JaeHyung | Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea; DGIST, Dept New Biol, Daegu 42988, South Korea; DGIST, New Biol Res Ctr NBRC, Daegu 42988, South Korea; Korea Brain Res Inst KBRI, Daegu 41062, South Korea | Koo, JaeHyung/R-3036-2019 | 55937716400; 8610443800 | heejincho@knu.ac.kr;jkoo001@dgist.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 54 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 5.041 | 36.2 | 0.7 | 2025-07-30 | 11 | 13 | Glioma; GPCR; Odorant receptor; OR51E1; OR51E2 | OLFACTORY RECEPTORS; PHYLOGENETIC ANALYSIS; REVEALS; EXPRESSION; DYSREGULATION; LANDSCAPE | Glioma; Gpcr; Odorant receptor; Or51e1; Or51e2 | Animals; Brain Neoplasms; Glioma; Isocitrate Dehydrogenase; Mice; Mutation; Odorants; Receptors, G-Protein-Coupled; Receptors, Odorant; fragrance; G protein coupled receptor; isocitrate dehydrogenase; Olfr558 protein, mouse; animal; brain tumor; genetics; glioma; metabolism; mouse; mutation; olfactory receptor; pathology | English | 2021 | 2021-12-31 | 10.5483/bmbrep.2021.54.12.165 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Perilipin 5 is a novel target of nuclear receptor LRH-1 to regulate hepatic triglycerides metabolism | Liver receptor homolog-1 (LRH-1) has emerged as a regulator of hepatic glucose, bile acid, and mitochondrial metabolism. However, the functional mechanism underlying the effect of LRH-1 on lipid mobilization has not been addressed. This study investigated the regulatory function of LRH-1 in lipid metabolism in maintaining a normal liver physiological state during fasting. The Lrh-1(f/f) and LRH-1 liver-specific knockout (Lrh-1(LKO)) mice were either fed or fasted for 24 h, and the liver and serum were isolated. The livers were used for qPCR, western blot, and histological analysis. Primary hepatocytes were isolated for immunocytochemistry assessments of lipids. During fasting, the Lrh-1(LKO) mice showed increased accumulation of triglycerides in the liver compared to that in Lrh-1(f/f) mice. Interestingly, in the Lrh-1(LKO) liver, decreases in perilipin 5 (PLIN5) expression and genes involved in beta-oxidation were observed. In addition, the LRH-1 agonist dialauroylphosphati-dylcholine also enhanced PLIN5 expression in human cultured HepG2 cells. To identify new target genes of LRH-1, these findings directed us to analyze the Plin5 promoter sequence, which revealed -1620/-1614 to be a putative binding site for LRH-1. This was confirmed by promoter activity and chromatin immuno-precipitation assays. Additionally, fasted Lrh-1(f/f) primary hepatocytes showed increased co-localization of PLIN5 in lipid droplets (LDs) compared to that in fasted Lrh-1(LKO) primary hepatocytes. Overall, these findings suggest that PLIN5 might be a novel target of LRH-1 to mobilize LDs, protect the liver from lipid overload, and manage the cellular needs during fasting. | Pantha, Rubee; Lee, Jae-Ho; Bae, Jae-Hoon; Koh, Eun Hee; Shin, Minsang; Song, Dae-Kyu; Im, Seung-Soon | Keimyung Univ, Dept Physiol, Sch Med, Daegu 42601, South Korea; Univ Ulsan, Asan Inst Life Sci, Dept Internal Med, Coll Med, Seoul 05505, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, Daegu 41944, South Korea | Lee, Jae-Ho/I-1935-2019 | 57284966500; 55224798300; 7201386763; 56659127600; 7401536650; 7402443802; 57211749547 | ssim73@kmu.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 54 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 5.041 | 36.2 | 0.07 | 2025-07-30 | 3 | 3 | Fasting; Lipid droplet; Liver receptor homolog-1; Perilipin 5; Triglycerides | ACCUMULATION; LIVER | Fasting; Lipid droplet; Liver receptor homolog-1; Perilipin 5; Triglycerides | Animals; Binding Sites; Hep G2 Cells; Hepatocytes; Humans; Lipid Droplets; Liver; Male; Mice; Mice, Knockout; Perilipin-5; Promoter Regions, Genetic; Protein Binding; Receptors, Cytoplasmic and Nuclear; Triglycerides; cell receptor; fat droplet; Nr5a2 protein, mouse; perilipin 5; protein binding; triacylglycerol; animal; binding site; chemistry; cytology; genetics; Hep-G2 cell line; human; knockout mouse; liver; liver cell; male; metabolism; mouse; promoter region | English | 2021 | 2021-09-30 | 10.5483/bmbrep.2021.54.9.051 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | The blood cerebrospinal fluid barrier orchestrates immunosurveillance, immunoprotection, and immunopathology in the central nervous system | Once characterized as an immune privileged area, recent scientific advances have demonstrated that the central nervous system (CNS) is both immunologically active and a specialized site. The anatomical and cellular features of the brain barriers, the glia limitans, and other superficial coverings of the CNS endow the brain with specificity for immune cell entry and other macro- and micro-elements to the brain. Cellular trafficking via barriers comprised of tightly junctioned non-fenestrated endothelium or tightly regulated fenestrated epithelium results in different phenotypic and cellular changes in the brain, that is, inflammatory versus regulatory changes. Based on emerging evidence, we described the unique ability of the blood cerebrospinal fluid barrier (BCSFB) to recruit, skew, and suppress immune cells. Additionally, we sum up the current knowledge on both cellular and molecular mechanisms governed by the choroid plexus and the cerebrospinal fluid at the BCSFB for immunosurveillance, immunoprotection, and immunopathology. | Ayub, Maria; Jin, Hee Kyung; Bae, Jae-sung | Kyungpook Natl Univ, KNU Alzheimers Dis Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, Daegu 41944, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu 41566, South Korea | Kim, Young/T-8521-2019; Bae, Jae-sung/AAM-8663-2021; Ayub, Maria/HBK-8730-2022 | 57223388486; 8088145800; 35209510400 | jsbae@knu.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 54 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 5.041 | 36.2 | 1.19 | 2025-07-30 | 25 | 24 | Brain barriers; Choroid plexus; Immunoregulation; Neuroimmune communication | CC-CHEMOKINE RECEPTOR; CHOROID-PLEXUS; T-CELLS; ADHESION MOLECULES; MULTIPLE-SCLEROSIS; TGF-BETA; CNS; INFLAMMATION; TRAFFICKING; MACROPHAGES | Brain barriers; Choroid plexus; Immunoregulation; Neuroimmune communication | Blood-Brain Barrier; Central Nervous System; Humans; blood brain barrier; central nervous system; human; immunology | English | 2021 | 2021-04-30 | 10.5483/bmbrep.2021.54.4.205 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The estrogen-related receptor. modulator, GSK5182, inhibits osteoclast differentiation and accelerates osteoclast apoptosis | Estrogen-related receptor gamma (ERR gamma), a member of the orphan nuclear receptor family, is a key mediator in cellular metabolic processes and energy homeostasis. Therefore, ERR. has become an attractive target for treating diverse metabolic disorders. We recently reported that ERR. acts as a negative regulator of osteoclastogenesis induced by receptor activator of nuclear factor-kappa B ligand (RANKL). In the present study, we explored the effects of an ERR.-specific modulator, GSK5182, on ERR gamma-regulated osteoclast differentiation and survival. Interestingly, GSK5182 increased ERR. protein levels much as does GSK4716, which is an ERR. agonist. GSK5182 inhibited osteoclast generation from bone-marrow-derived macrophages without affecting cytotoxicity. GSK5182 also attenuated RANKL-mediated expression of c-Fos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), pivotal transcription factors for osteoclastogenesis. Arrested osteoclast differentiation was associated with reduced RANK expression, but not with the M-CSF receptor, c-Fms. GSK5182 strongly blocked the phosphorylation of I kappa B alpha, c-Jun N-terminal kinase, and extracellular signal-regulated kinase in response to RANKL. GSK5182 also suppressed NF-kappa B promoter activity in a dose-dependent manner. In addition to osteoclastogenesis, GSK5182 accelerated osteoclast apoptosis by caspase-3 activation. Together, these results suggest that GSK5182, a synthetic ERR. modulator, may have potential in treating disorders related to bone resorption. | Kim, Hyun-Ju; Yoon, Hye-Jin; Lee, Dong-Kyo; Jin, Xian; Che, Xiangguo; Choi, Je-Yong | Kyungpook Natl Univ, Dept Biochem & Cell Biol, Cell & Matrix Res Inst,Sch Med, Korea Mouse Phenotyping Ctr,KNU Convergence Educ, Daegu 41944, South Korea | ; Choi, Je-Yong/AAR-7334-2021 | 57208650339; 57191982008; 57216603928; 57204810645; 54792660600; 7501391068 | biohjk@knu.ac.kr;jechoi@knu.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 54 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 5.041 | 36.2 | 0.49 | 2025-07-30 | 10 | 10 | Apoptosis; ERR.; GSK5182; NFATc1; Osteoclast | GAMMA ERR-GAMMA; INVERSE AGONIST; KEY REGULATOR; KAPPA-B; ORPHAN; BONE; LIGAND; IDENTIFICATION; ACTIVATION | Apoptosis; ERRy; GSK5182; NFATc1; Osteoclast | Animals; Apoptosis; Cell Differentiation; Cell Line; Cell Survival; Male; Mice; Mice, Inbred C57BL; Osteoclasts; Tamoxifen; GSK5182; tamoxifen; animal; apoptosis; C57BL mouse; cell differentiation; cell line; cell survival; drug effect; male; metabolism; mouse; osteoclast | English | 2021 | 2021-05-31 | 10.5483/bmbrep.2021.54.5.243 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | "Reverse miss-a-nail technique" of reconstruction nailing for successful fixation of the ipsilateral femoral neck and shaft fracture | Introduction Although reconstruction nails have an advantage of single-construct fixation in ipsilateral femoral neck and shaft fractures, they have not been used widely due to the technical challenges associated with their placement. Reduction is particularly demanding in patients with displaced neck fractures after nailing of the shaft fracture, and can be resulted in nonunion, malunion, and osteonecrosis. We report a new technique of reconstruction nailing after the provisional reduction and fixation of a neck fracture to achieve successful healing of this injury. Materials and methods Osteosynthesis using a reconstruction nail was performed in ten consecutive patients with displaced femoral neck and shaft fracture. After closed reduction of the displaced neck fracture, the femoral neck was provisionally fixed with pins in an anterolateral-to-medial direction. While maintaining reduction of the neck fracture, a nail was inserted and passed into the medullary canal posterior to the provisionally fixed pins with indirect reduction of the shaft fracture. After two reconstruction locking screws were fixed for proximal interlocking, the provisional pins were removed once distal interlocking was achieved. The radiologic outcomes included quality of reduction, healing rate, and time to the union were appraised, and the functional outcomes were assessed with Friedman and Wyman's criteria. Results This novel technique provided satisfactory reduction of both the femoral neck and shaft fractures with no malunion. All fractures achieved primary union, except for one case of nonunion of femoral shaft. Eight of ten patients experienced good results in functional outcome, whereas the remaining two patients reported moderate limitations in activities of daily living. At the latest follow-up, all patients had excellent range of motion in hip and knee joints. Conclusions Provisional fixation after reduction of a femoral neck fracture may facilitate successful reconstruction nailing in the ipsilateral fractures of the femoral neck and shaft. This "Reverse Miss-a-Nail Technique" may minimize complications and maximize the radiologic and functional outcomes of patients who experience this injury. | Oh, Chang-Wug; Kim, Joon-Woo; Oh, Jong-Keon; Apivatthakakul, Theerachai; Park, Kyeong-Hyeon; Hong, Wonki | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthopaed Surg, 130 Dongduk Ro, Daegu 41944, South Korea; Korea Univ Guro Hosp, Dept Orthopaed Surg, 148 Gurodong Ro, Seoul 08308, South Korea; Chiang Mai Univ, Fac Med, Dept Orthopaed, 10 Suthep Rd,T Suthep, Chiang Mai 50200, Thailand | ; Oh, Chang-Wug/AAO-4602-2021; Park, KyeongHyeon/KEH-4919-2024 | 22135834200; 22951329000; 7402155046; 8632031200; 56969984400; 57218322356 | joonwoo@knu.ac.kr; | ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | ARCH ORTHOP TRAUM SU | 0936-8051 | 1434-3916 | 141 | 6 | SCIE | ORTHOPEDICS;SURGERY | 2021 | 2.928 | 36.4 | 0.74 | 2025-07-30 | 5 | 6 | Ipsilateral femoral neck and shaft fracture; Provisional fixation; Reconstruction nail; Reverse miss-a-nail technique | HIP | Ipsilateral femoral neck and shaft fracture; Provisional fixation; Reconstruction nail; Reverse miss-a-nail technique | Bone Nails; Femoral Fractures; Femur; Fracture Fixation, Intramedullary; Humans; Range of Motion, Articular; Treatment Outcome; adult; aged; Article; clinical article; clinical outcome; closed fracture reduction; controlled study; daily life activity; femoral neck fracture; femur shaft fracture; follow up; fracture fixation; fracture healing; fracture reduction; Friedman and Wyman criteria; functional status assessment; hip; human; intramedullary nailing; joint characteristics and functions; knee; male; middle aged; osteosynthesis; prospective study; reverse miss a nail technique; surgical technique; adverse device effect; adverse event; bone nail; devices; femur; femur fracture; physiology; procedures; treatment outcome | English | 2021 | 2021-06 | 10.1007/s00402-020-03620-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Clinical outcome of staged surgery after primary amputation for mangled extremity | Introduction Amputation for a mangled extremity is an effective and reliable life-saving treatment method, which requires a relatively shorter duration for treatment than limb salvage. However, only a few studies have focused on treatment with amputation. Herein, we report good clinical outcomes achieved through staged surgery performed after amputation. Materials and methods This study included 47 patients (38 men, 9 women; average age, 52.4 years) diagnosed with mangled extremity, who underwent primary amputation between March 2014 and January 2019. The patients were divided into the initial closure (IC) groups (including 26 patients who underwent IC after amputation) and staged surgery (SS) (including 21 patients who underwent SS after amputation) groups. The presence of complications including necrosis and infection, consequent additional surgery, duration of hospitalization and expense for treatment, and functional scores of upper and lower extremities were assessed. Results No specific postoperative complication was found in the SS group. However, additional surgeries were performed in the IC group because of complications including three cases of infection and two cases of necrosis. The differences between the hospitalization period, treatment cost, and functional examination conducted 1 year after surgery of the two groups were not statistically significant. The patients in the IC group who underwent additional surgery were hospitalized for a longer period and presented with lower functional scores due to delayed rehabilitation. Conclusion Staged surgery is a definitive and safe treatment option that can effectively reduce complications including infection and necrosis in patients with mangled extremity. | Yoon, Yong-Cheol; Oh, Chang-Wug; Jang, Myung Jin; Kim, Han Soul; Oh, Jong-Keon | Gachon Univ, Trauma Ctr, Orthoped Trauma Div, Coll Med, Incheon, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthoped Surg, Daegu, South Korea; Gachon Univ, Dept Orthoped Surg, Coll Med, Incheon, South Korea; Korea Univ, Guro Hosp, Dept Orthoped Surg, Coll Med, 148 Gurodong Ro, Seoul 08308, South Korea | Oh, Chang-Wug/AAO-4602-2021; Yong-Cheol, Yoon/HPD-8077-2023 | 37082544400; 22135834200; 57217087382; 57217085843; 7402155046 | jkoh@korea.ac.kr; | ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | ARCH ORTHOP TRAUM SU | 0936-8051 | 1434-3916 | 141 | 3 | SCIE | ORTHOPEDICS;SURGERY | 2021 | 2.928 | 36.4 | 0 | 2025-07-30 | 1 | 1 | Mangled extremity; Amputation; Complication; Staged surgery | MANAGEMENT; INFECTION; FRACTURES; SCORE | Amputation; Complication; Mangled extremity; Staged surgery | Amputation; Female; Humans; Lower Extremity; Male; Middle Aged; Treatment Outcome; Upper Extremity; adult; aged; arm amputation; arm injury; Article; clinical article; clinical decision making; clinical outcome; controlled study; deep vein thrombosis; female; functional status assessment; health care cost; heterotopic ossification; hospitalization; human; initial closure; leg amputation; leg injury; limb amputation; limb salvage; male; mangled extremity; middle aged; necrosis; phantom pain; postoperative complication; postoperative infection; staged surgery; surgical patient; very elderly; wound dehiscence; amputation; injury; lower limb; surgery; treatment outcome; upper limb | English | 2021 | 2021-03 | 10.1007/s00402-020-03497-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | CLUSTERING ON THE TORUS BY CONFORMAL PREDICTION | Motivated by the analysis of torsion (dihedral) angles in the backbone of proteins, we investigate clustering of bivariate angular data on the torus [-pi, pi) x [-pi, pi). We show that naive adaptations of clustering methods, designed for vector-valued data, to the torus are not satisfactory and propose a novel clustering approach based on the conformal prediction framework. We construct several prediction sets for toroidal data with guaranteed finite-sample validity, based on a kernel density estimate and bivariate von Mises mixture models. From a prediction set built from a Gaussian approximation of the bivariate von Mises mixture, we propose a data-driven choice for the number of clusters and present algorithms for an automated cluster identification and cluster membership assignment. The proposed prediction sets and clustering approaches are applied to the torsion angles extracted from three strains of coronavirus spike glycoproteins (including SARS-CoV-2, contagious in humans). The analysis reveals a potential difference in the clusters of the SARS-CoV-2 torsion angles, compared to the clusters found in torsion angles from two different strains of coronavirus, contagious in animals. | Jung, Sungkyu; Park, Kiho; Kim, Byungwon | Seoul Natl Univ, Dept Stat, Seoul, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea | Jung, Sungkyu/AFA-8963-2022 | 35299524400; 57468891500; 57205674498 | sungkyu@snu.ac.kr;pkh503201@snu.ac.kr;byungwonkim@knu.ac.kr; | ANNALS OF APPLIED STATISTICS | ANN APPL STAT | 1932-6157 | 1941-7330 | 15 | 4 | SCIE | STATISTICS & PROBABILITY | 2021 | 1.959 | 36.4 | 0.53 | 2025-07-30 | 5 | 6 | Directional statistics; torsion angles; von Mises distribution; prediction set; density estimation; protein structure | VON-MISES DISTRIBUTION; DENSITY-ESTIMATION; PROTEIN; DISTRIBUTIONS; MIXTURES | Density estimation; Directional statistics; Prediction set; Protein structure; Torsion angles; Von Mises distribution | English | 2021 | 2021-12 | 10.1214/21-aoas1459 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Efficient knowledge distillation for liver CT segmentation using growing assistant network | Segmentation has been widely used in diagnosis, lesion detection, and surgery planning. Although deep learning (DL)-based segmentation methods currently outperform traditional methods, most DL-based segmentation models are computationally expensive and memory inefficient, which are not suitable for the intervention of liver surgery. To address this issue, a simple solution is to make a segmentation model very small for the fast inference time, however, there is a trade-off between the model size and performance. In this paper, we propose a DL-based real-time 3-D liver CT segmentation method, where knowledge distillation (KD) method, known as knowledge transfer from teacher to student models, is incorporated to compress the model while preserving the performance. Because it is well known that the knowledge transfer is inefficient when the disparity of teacher and student model sizes is large, we propose a growing teacher assistant network (GTAN) to gradually learn the knowledge without extra computational cost, which can efficiently transfer knowledge even with the large gap of teacher and student model sizes. In our results, dice similarity coefficient of the student model with KD improved 1.2% (85.9% to 87.1%) compared to the student model without KD, which is a similar performance of the teacher model using only 8% (100k) parameters. Furthermore, with a student model of 2% (30k) parameters, the proposed model using the GTAN improved the dice coefficient about 2% compared to the student model without KD, and the inference time is 13 ms per a 3-D image. Therefore, the proposed method has a great potential for intervention in liver surgery as well as in many real-time applications. | Xu, Pengcheng; Kim, Kyungsang; Koh, Jeongwan; Wu, Dufan; Rim Lee, Yu; Young Park, Soo; Young Tak, Won; Liu, Huafeng; Li, Quanzheng | Zhejiang Univ, Coll Opt Sci & Engn, Hangzhou, Peoples R China; Harvard Med Sch, Dept Radiol, 55 Fruit St, Boston, MA 02114 USA; Massachusetts Gen Hosp, Dept Radiol, 55 Fruit St, Boston, MA 02114 USA; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Wu, Dufan/AFZ-1956-2022; xu, pengcheng/GWD-1328-2022 | 57220762089; 44861409500; 57364303000; 55286668100; 58123403300; 57364686300; 57364303100; 7409750199; 7405862484 | 11830045@zju.edu.cn;kkim24@mgh.harvard.edu;liuhf@zju.edu.cn;li.Quanzheng@mgh.harvard.edu; | PHYSICS IN MEDICINE AND BIOLOGY | PHYS MED BIOL | 0031-9155 | 1361-6560 | 66 | 23 | SCIE | ENGINEERING, BIOMEDICAL;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2021 | 4.174 | 36.4 | 0.75 | 2025-07-30 | 8 | 9 | knowledge distillation; liver segmentation; deep learning | RESECTION | deep learning; knowledge distillation; liver segmentation | Humans; Liver; Radionuclide Imaging; Tomography, X-Ray Computed; Computerized tomography; Deep learning; Diagnosis; Distillation; Economic and social effects; Knowledge management; Students; Surgery; CT segmentation; Deep learning; Knowledge distillation; Learning-based segmentation; Liver CT; Liver segmentation; Model size; Student Modeling; Teacher models; Teachers'; diagnostic imaging; human; liver; scintiscanning; x-ray computed tomography; Image enhancement | English | 2021 | 2021-12-07 | 10.1088/1361-6560/ac3935 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Excellent outcomes after double-locked plating in very low periprosthetic distal femoral fractures | Introduction Very low periprosthetic distal femur fractures (PPDFFs) are rare injuries and often have a relatively high failure rate after single lateral locked plating. The double plating technique yields good outcomes in osteoporotic fractures of the distal femur. To date, there is limited information on double-locked plate fixation of very low PPDFFs. This study aimed to evaluate the outcomes and complications of surgically treated very low PPDFFs using double-locked plate fixation. Materials and methods Between January 2013 and December 2018, sixty-one consecutive patients with PPDFFs have been conducted. Only Su type III PPDFFs with double-locked plate fixation through a lateral minimally invasive approach and a medial subvastus approach to the distal femur were analyzed. Patients were encouraged to perform straight leg raising exercises and active knee motion on the second postoperative day. Assisted weight bearing from the early postoperative days was supported, and full weight-bearing was allowed after healing the fracture site. All patients were evaluated according to the time to union, limb alignment, range of knee motion, Knee Society Score, and presence of complications. Results Twenty one patients (17 females and 4 males, mean age 76 years, range 56-90) were included in the study. There were 10 of 33-A1, 6 of 33-A2 and 5 of 33 A3 fractures, according to the AO classification. Of 21 patients, 20 achieved union at an average of 14 weeks postoperatively. Postoperative limb alignment was satisfactory in all cases, with an average mechanical distal lateral femur angle of 89 degrees and average mechanical posterior distal femur angle of 86 degrees. All patients recovered the knee joint motion similar to that of the contralateral side, and daily life pre-injury. The average knee and function scores were 94 and 89, respectively. There were one case of non-union and three cases of superficial wound infection, which resolved after intravenous antibiotic therapy. Conclusions Double locked plating showed excellent radiographic and functional outcomes with few complications in patients with very low PPDFFs. Based on these promising results, we propose the consideration of double-locked plate fixation in the treatment of very low PPDFFs. | Park, Kyeong-Hyeon; Oh, Chang-Wug; Park, Ki-Chul; Kim, Joon-Woo; Oh, Jong-Keon; Kyung, Hee-Soo; Kim, Hee-June; Yoon, Yong-Cheol | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Orthopaed Surg, 130 Dongdeok Ro, Daegu 41944, South Korea; Hanyang Univ, Sch Med, Guri Hosp, Dept Orthopaed Surg, Guri Si, Gyeonggi Do Pro, South Korea; Korea Univ, Sch Med, Guro Hosp, Dept Orthopaed Surg, Seoul, South Korea; Gachon Univ, Trauma Ctr, Coll Med, Orthoped Trauma Div, 21 Namdong Daero,774 Beon Gil, Incheon 21565, South Korea | ; Park, KyeongHyeon/KEH-4919-2024; Oh, Chang-Wug/AAO-4602-2021; Yong-Cheol, Yoon/HPD-8077-2023 | 56969984400; 22135834200; 56062454500; 22951329000; 7402155046; 7004292406; 36463735200; 37082544400 | cwoh@knu.ac.kr; | ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | ARCH ORTHOP TRAUM SU | 0936-8051 | 1434-3916 | 141 | 2 | SCIE | ORTHOPEDICS;SURGERY | 2021 | 2.928 | 36.4 | 3.56 | 2025-07-30 | 26 | 26 | Distal femur fracture; Periprosthetic fracture; Su classification; Double plate; Locked plate | TOTAL KNEE ARTHROPLASTY; SUPRACONDYLAR FEMUR FRACTURES; FIXATION; STABILIZATION; REVISION; LISS; MANAGEMENT; PLATES; NAIL | Distal femur fracture; Double plate; Locked plate; Periprosthetic fracture; Su classification | Aged; Aged, 80 and over; Bone Plates; Female; Femoral Fractures; Fracture Fixation, Internal; Humans; Knee Joint; Male; Middle Aged; Periprosthetic Fractures; Postoperative Complications; Treatment Outcome; adult; aged; Article; causal attribution; clinical article; convalescence; distal femur fracture; double locked plate fixation; female; fracture fixation; fracture nonunion; human; joint function; knee osteoarthritis; male; periprosthetic fracture; postoperative care; range of motion; retrospective study; total knee arthroplasty; treatment outcome; treatment planning; weight bearing; wound infection; adverse event; bone plate; devices; femur fracture; knee; middle aged; osteosynthesis; periprosthetic fracture; postoperative complication; procedures; very elderly | English | 2021 | 2021-02 | 10.1007/s00402-020-03655-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Astrovirus Infection in Cattle with Nonsuppurative Meningoencephalitis in South Korea | Neurological diseases in cattle can be caused by several infectious agents. Astroviruses are increasingly recognized as the causative agent of encephalitis in various animals, including humans. In this study, a neuroinvasive astrovirus (BoAstV 20B05) was discovered in the brain tissues of an 81-month-old Korean native cattle with neurological symptoms. Lymphocyte infiltration and multifocal perivascular cuffing were observed in the cerebrum and brain stem, and viral antigens were also detected in the meninges. In particular, the concentration of the astroviral genome was high in the brain tissues. Korean BoAstV 20B05 was classified into the CH13/NeuroS1 clade and was closely related to the Neuro-Uy and KagoshimaSR28-462 strains. Our evolutionary analysis showed that Korean BoAstV 20B05 belongs to the sub-lineage NeuroS1 and evolved independently of BoAstV KagoshimaSR28-462. These results suggest that neuroinvasive astroviruses were first introduced in Korea. However, analysis is limited by the lack of reference astrovirus sequences reported in various countries within Asia, and further analysis should be performed using more strains. In this study, we identified a neuroinvasive astrovirus infection with neurological symptoms for the first time in South Korea and confirmed that BoAstV 20B05 may have been introduced in South Korea a long time ago. | Lee, Sook-Young; Kim, Jong-Ho; Kim, Yoon-Ji; Kim, Young-Sik; Roh, Su-Gwon; Lee, Kyung-Hyun; Kim, Heui-Jin; Shin, Jae-Ho; Oem, Jae-Ku | Jeonbuk Natl Univ, Coll Vet Med, Lab Vet Infect Dis, Iksan 54596, South Korea; Anim & Plant Quarantine Agcy, Anim Dis Diagnost Div, 117 Hyeoksin 8 Ro, Kimcheon Si 39660, Gyeongsanbuk Do, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, 80 Daehak Ro, Daegu 41566, South Korea | 54410896200; 57202162365; 57222424425; 57214047069; 57200497426; 35183367100; 57223133138; 57224125922; 6506283913 | sylee163@gmail.com;whdgh2339@korea.kr;kimyoonji102@naver.com;yoksik@naver.com;sujza26@naver.com;mylovehyun@korea.kr;jennykim@korea.kr;jhshin@knu.ac.kr;jku0623@jbnu.ac.kr; | VIRUSES-BASEL | VIRUSES-BASEL | 1999-4915 | 13 | 10 | SCIE | VIROLOGY | 2021 | 5.818 | 36.5 | 0.31 | 2025-07-30 | 5 | 5 | astrovirus; encephalomeningitis; nonsuppurative; neurological disease; bovine | BOVINE ASTROVIRUS; ENCEPHALITIS; DISEASE; BIOLOGY | Astrovirus; Bovine; Encephalomeningitis; Neurological disease; Nonsuppurative | Animals; Astroviridae Infections; Brain; Cattle; Cattle Diseases; Encephalitis, Viral; Meningoencephalitis; Phylogeny; Republic of Korea; coronavirus RNA dependent RNA polymerase; ORF2 protein; protein; unclassified drug; virus antigen; Aino virus; Akabane virus; animal experiment; animal model; Article; Astroviridae; astrovirus infection; ataxia; bovine; Bovine ephemeral fever virus; Bovine herpesvirus 1; Bovine viral diarrhea virus 1; brain; brain tissue; cell infiltration; cerebellum; depression; evolution; forebrain; genetic analysis; genetic evolutionary analysis; histopathology; in situ hybridization; leukocyte aggregation; Listeria monocytogenes; lymph node; lymphocyte; lymphocytic infiltration; macrophage; maximum likelihood method; meningoencephalitis; mesencephalon; mononuclear cell; neurologic disease; nonhuman; paralysis; pathology; perivascular cuffing; phylogeny; plasma cell; real time polymerase chain reaction; RNA extraction; RNA sequencing; virus detection; virus strain; animal; astrovirus infection; bovine; cattle disease; classification; complication; meningoencephalitis; mortality; South Korea; veterinary medicine; virology; virus encephalitis | English | 2021 | 2021-10 | 10.3390/v13101941 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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