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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Review | The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease | Mucus is present throughout the gastrointestinal tract and is essential for regulating gut microbiota homeostasis and preventing disease by protecting the gastrointestinal barrier from microorganisms, pathogens and toxins or other irritants. Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as the main component of mucus. Defects in the gastrointestinal tract, such as inflammation and ulcers, cause damage to the mucus barrier, which can worsen mucus quality and reduce mucus production. Therefore, we would like to review the characteristics of MUC2 and its role in intestinal disorders and highlight the importance of further studies. We also investigated whether the role of MUC2 differs between children and adults, ulcerative colitis (UC) and Crohn's disease (CD). | Kang, Youra; Park, Hyeonjeong; Choe, Byung-Ho; Kang, Ben | Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea | 康, 奔/JMQ-0812-2023; Choe, Byung-Ho/KSM-6251-2024 | 57464178600; 57697987100; 57574977300; 57194823199 | benkang@knu.ac.kr; | FRONTIERS IN MEDICINE | FRONT MED-LAUSANNE | 2296-858X | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 6.38 | 2025-06-25 | 82 | 82 | mucins; mucus; inflammatory bowel diseases; ulcerative colitis; Crohn's disease | INTESTINAL MUCIN; GENE-EXPRESSION; INCREASED SUSCEPTIBILITY; ULCERATIVE-COLITIS; TREFOIL FACTORS; TNF-ALPHA; MOLECULAR-CLONING; EPITHELIAL-CELLS; CROHNS-DISEASE; COLONIC MUCIN | Crohn's disease; inflammatory bowel diseases; mucins; mucus; ulcerative colitis | mucin 2; classification; Crohn disease; groups by age; human; inflammatory bowel disease; nonhuman; protein glycosylation; protein secretion; protein structure; protein synthesis; regulatory mechanism; Review; small intestine; ulcerative colitis | English | 2022 | 2022-05-06 | 10.3389/fmed.2022.848344 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | The Role of Factor Xa-Independent Pathway and Anticoagulant Therapies in Cancer-Related Stroke | Background: The optimal strategy for stroke prevention in cancer patients is unknown. We compared the underlying mechanisms of coagulopathy and the effects of anticoagulants in patients with active cancer and atrial fibrillation (AF). Methods: We retrospectively enrolled 46 consecutive patients with embolic stroke of unknown source and active cancer (cancer stroke). We consecutively screened patients with cancer patients without stroke (n = 29), AF stroke (n = 52), and healthy subjects (n = 28), which served as controls. Patients with cancer stroke were treated with either enoxaparin (a low-molecular-weight heparin) or a factor Xa inhibitor, and those with AF stroke were treated with factor Xa inhibitors. D-dimer, factor Xa, and circulating cell-free DNA (cfDNA), a marker of neutrophil extracellular traposis, were measured at both before and after anticoagulation. Results: In AF stroke, factor Xa activity and cfDNA and D-dimer levels were decreased by treatment with factor Xa inhibitors. In contrast, in cancer stroke, factor Xa activity was decreased, D-dimer levels were unchanged, and cfDNA levels were increased by treatment with factor Xa inhibitors. In cancer stroke patients treated with enoxaparin, D-dimer levels were decreased (p = 0.011) and cfDNA levels were unchanged. Conclusion: The anticoagulation effects of factor Xa inhibitors differed between cancer stroke and AF stroke. | Kim, Hyung Jun; Chung, Jong-Won; Bang, Oh Young; Cho, Yeon Hee; Lim, Yun Jeong; Hwang, Jaechun; Seo, Woo-Keun; Kim, Gyeong-Moon; Kim, Hee-Jin; Ahn, Myung-Ju | Ewha Womans Univ, Seoul Hosp, Coll Med, Dept Neurol, Seoul 07804, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul 06351, South Korea; Samsung Med Ctr, Translat & Stem Cell Res Lab Stroke, Seoul 06351, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Neurol, Daegu 41404, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Lab Med & Genet, Seoul 06351, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Hematooncol, Seoul 06351, South Korea | ; Kim, Hee/AAU-6368-2021 | 55635231700; 55553751200; 7006620221; 55548153800; 56501161800; 54980345300; 22981667600; 35237139600; 36168944100; 7103352186 | khhhj7@naver.com;neurocjw@gmail.com;hyoung.bang@samsung.com;cyeon2@empas.com;smcyunjeong@naver.com;ghkdwocns@gmail.com;mcastenosis@gmail.com;kimgm@skku.edu;hee_jin.kim@samsung.com;silk.ahn@samsung.com;ohyoung.bang@samsung.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 1 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 1.12 | 2025-06-25 | 7 | 7 | stroke; coagulopathy; thrombosis; cancer; anticoagulation | DIRECT ORAL ANTICOAGULANTS; VENOUS THROMBOEMBOLISM PROPHYLAXIS; ISCHEMIC-STROKE; AMERICAN SOCIETY; THROMBOSIS; SYSTEM | Anticoagulation; Cancer; Coagulopathy; Stroke; Thrombosis | anticoagulant agent; antineoplastic agent; apixaban; blood clotting factor 10a; circulating free DNA; D dimer; edoxaban; enoxaparin; glycoprotein P inhibitor; low molecular weight heparin; rivaroxaban; adult; aged; anticoagulant therapy; Article; atrial fibrillation; bile duct cancer; breast cancer; cancer patient; cancer related stroke; cardioembolic stroke; clinical article; controlled study; diabetes mellitus; disease association; drug dose reduction; female; female genital tract cancer; gastrointestinal cancer; human; hypercoagulability; hyperlipidemia; hypertension; ischemic stroke; liver cancer; lung cancer; male; malignant neoplasm; NETosis; neutrophil; primary tumor; retrospective study; risk factor; smoking; stroke patient | English | 2022 | 2022-01 | 10.3390/jcm11010123 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | 4-phenylpyridine suppresses UVB-induced skin inflammation by targeting c-Src in vitro and in vivo | Acute or repetitive exposure to ultraviolet (UV) cause disruptions to the skin barrier and subsequent inflammatory skin disease. 4-phenylpyridine (4-PP) is a constituent of Brassica campestris L. ssp. Pekinensis and its effect on skin inflammation and molecular target remain unclear. The purpose of this study is to confirm the anti-inflammatory efficacy of 4-PP on UVB-induced skin inflammation in human keratinocytes HaCaT and mouse skin and validation of its molecular target. 4-PP also attenuated UVB-induced phosphorylation of p38/mitogen-activated protein kinase kinase (MKK) 3/6, c-Jun N-terminal kinase 1/2, MKK 4/7, extracellular-signal-regulated kinase 1/2, mitogen-activated protein kinase 1/2. Additionally, 4-PP inhibited UVB-induced phosphorylation of epidermal growth factor receptor (EGFR) Y1068, Y1045 and 854 residues but not the proto-oncogene tyrosine-protein kinase c-Src. Drug affinity responsive target stability assay revealed that 4-PP directly binds to c-Src and inhibits pronase c-proteolysis. Knockdown of c-Src inhibited UVB-induced COX-2 expression and phosphorylation of MAPKs and EGFR in HaCaT cells. Dorsal treatment of 4-PP prevented UVB (0.5 J/cm(2))-induced skin thickness, phosphorylation of EGFR and COX-2 expression in mouse skin. Our findings suggest that 4-PP can be used as anti-inflammatory agent with an effect of skin inflammation by inhibiting the COX-2 expression via suppressing the c-Src/EGFR/MAPKs signalling pathway. | Kim, Ju Gyeong; Kang, Ha Yeong; Kim, Min Jeong; Lim, Seokwon; Lee, Chang Joo; Kim, Kyung-Min; Jung, Sung Keun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Gachon Univ, Dept Food Sci & Biotechnol, Seongnam Si, Gyeonggi Do, South Korea; Wonkwang Univ, Dept Food Sci & Biotechnol, Iksan, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu, South Korea | ; Kim, Kyung-Min Kim/C-7007-2014; Jung, SUNG KEUN/AGR-2623-2022; Lee, Eun-Hye/KDN-5679-2024 | 57216640718; 57733176700; 57215818497; 36183480900; 17338876600; 34868260300; 35310491400 | skjung04@knu.ac.kr; | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | J CELL MOL MED | 1582-1838 | 1582-4934 | 26 | 14 | SCIE | CELL BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 5.3 | 34.2 | 0.84 | 2025-06-25 | 10 | 10 | 4-phenylpyridine; Brassica campestris L; ssp; pekinensis; COX-2; c-Src; phytochemicals; skin inflammation | COX-2 EXPRESSION; PHOSPHORYLATION; RADIATION; EXTRACT; KINASE | 4-phenylpyridine; Brassica campestris L. ssp. pekinensis; c-Src; COX-2; phytochemicals; skin inflammation | Animals; Cyclooxygenase 2; Dermatitis; ErbB Receptors; Humans; Inflammation; Keratinocytes; Mice; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyridines; Skin; Ultraviolet Rays; 4 phenylpyridine; antiinflammatory agent; cyclooxygenase 2; epidermal growth factor receptor; immunoglobulin enhancer binding protein; messenger RNA; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 14; mitogen activated protein kinase 3; mitogen activated protein kinase 9; mitogen activated protein kinase kinase 4; mitogen activated protein kinase kinase 7; mitogen activated protein kinase p38; prostaglandin E2; pyridine derivative; stress activated protein kinase 1; unclassified drug; 4-phenylpyridine; cyclooxygenase 2; epidermal growth factor receptor; protein kinase p60; protein tyrosine kinase; pyridine derivative; animal experiment; apoptosis; Article; bone metabolism; carcinogenesis; chemoluminescence; chromatin immunoprecipitation; controlled study; dermatitis; environmental factor; enzyme immunoassay; enzyme linked immunosorbent assay; gene silencing; genetic transfection; HaCat cell line; human; human cell; immunofluorescence; immunofluorescence assay; in vitro study; in vivo study; male; MAPK signaling; mouse; nonhuman; oilseed turnip; oncogene src; protein degradation; protein expression; protein phosphorylation; proto oncogene; real time polymerase chain reaction; RNA isolation; skinfold thickness; ultraviolet B radiation; validation process; Vibrio cholerae; Western blotting; adverse event; animal; dermatitis; inflammation; keratinocyte; metabolism; phosphorylation; skin; ultraviolet radiation | English | 2022 | 2022-07 | 10.1111/jcmm.17422 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Beam-recoil transferred polarization in K⁺Y electroproduction in the nucleon resonance region with CLAS12 | Beam-recoil transferred polarizations for the exclusive electroproduction of K+ Lambda and K+Sigma(0) final states from an unpolarized proton target have been measured using the CLAS12 spectrometer at Jefferson Laboratory. The measurements at beam energies of 6.535 and 7.546 GeV span the range of four-momentum transfer Q(2) from 0.3 to 4.5 GeV2 and invariant energy W from 1.6 to 2.4 GeV, while covering the full center-of-mass angular range of the K+. These new data extend the existing hyperon polarization data from CLAS in a similar kinematic range but from a significantly larger dataset. They represent an important addition to the world data, allowing for better exploration of the reaction mechanism in strangeness production processes, for further understanding of the spectrum and structure of excited nucleon states, and for improved insight into the strong interaction in the regime of nonperturbative dynamics. | Carman, D. S.; D'Angelo, A.; Lanza, L.; Mokeev, V., I; Adhikari, K. P.; Amaryan, M. J.; Armstrong, W. R.; Atac, H.; Avakian, H.; Gayoso, C. Ayerbe; Baltzell, N. A.; Barion, L.; Bedlinskiy, I; Battaglieri, M.; Benkel, B.; Bianconi, A.; Biselli, A. S.; Bondi, M.; Boiarinov, S.; Bossu, F.; Briscoe, W. J.; Bueltmann, S.; Bulumulla, D.; Burkert, V. D.; Capobianco, R.; Carvajal, J. C.; Celentano, A.; Chatagnon, P.; Chesnokov, V; Chetry, T.; Ciullo, G.; Clark, L.; Cole, P. L.; Contalbrigo, M.; Costantini, G.; Crede, V; Dashyan, N.; De Vita, R.; Defurne, M.; Deur, A.; Diehl, S.; Djalali, C.; Dupre, R.; Ehrhart, M.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Fegan, S.; Filippi, A.; Gavalian, G.; Ghandilyan, Y.; Gilfoyle, G. P.; Girod, F. X.; Glazier, D., I; Golubenko, A. A.; Gothe, R. W.; Gotra, Y.; Griffioen, K. A.; Hafidi, K.; Hakobyan, H.; Hattawy, M.; Hauenstein, F.; Hayward, T. B.; Hobart, A.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Isupov, E. L.; Jo, H. S.; Joo, K.; Keller, D.; Khanal, A.; Kim, A.; Kim, W.; Klimenko, V; Kripko, A.; Kubarovsky, V; Leali, M.; Lee, S.; Lenisa, P.; Livingston, K.; MacGregor, I. J. D.; Marchand, D.; Marsicano, L.; Mascagna, V; Mayer, M.; McKinnon, B.; Migliorati, S.; Mineeva, T.; Mirazita, M.; Montgomery, R. A.; Camacho, C. Munoz; Nadel-Turonski, P.; Neupane, K.; Newton, J.; Niccolai, S.; Osipenko, M.; Pandey, P.; Paolone, M.; Pappalardo, L. L.; Paremuzyan, R.; Pasyuk, E.; Paul, S. J.; Pilleux, N.; Pogorelko, O.; Price, J. W.; Prok, Y.; Raue, B. A.; Reed, T.; Ripani, M.; Ritman, J.; Rizzo, A.; Rossi, P.; Sabatie, F.; Salgado, C.; Schmidt, A.; Sharabian, Y. G.; Shirokov, E., V; Shrestha, U.; Simmerling, P.; Sokhan, D.; Sparveris, N.; Stepanyan, S.; Strakovsky, I. I.; Strauch, S.; Tyler, N.; Tyson, R.; Ungaro, M.; Vallarino, S.; Venturelli, L.; Voskanyan, H.; Voutier, E.; Watts, D. P.; Wei, K.; Wei, X.; Wishart, R.; Wood, M. H.; Yale, B.; Zachariou, N.; Zhang, J.; Ziegler, V | Argonne Natl Lab, Argonne, IL 60439 USA; Univ Brescia, I-25123 Brescia, Italy; Univ Calif Riverside, 900 Univ Ave, Riverside, CA 92521 USA; Calif State Univ Dominguez Hills, Carson, CA 90747 USA; Canisius Coll, Buffalo, NY 14208 USA; Univ Connecticut, Storrs, CT 06269 USA; Fairfield Univ, Fairfield, CT 06824 USA; Univ Ferrara, I-44121 Ferrara, Italy; Florida Int Univ, Miami, FL 33199 USA; Florida State Univ, Tallahassee, FL 32306 USA; Univ Giessen, Phys Inst 2, D-35392 Giessen, Germany; George Washington Univ, Washington, DC 20052 USA; Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland; Hampton Univ, Hampton, VA 23669 USA; Ist Nazl Fis Nucl, Sez Ferrara, I-44100 Ferrara, Italy; Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy; Ist Nazl Fis Nucl, Sez Genova, I-16146 Genoa, Italy; Ist Nazl Fis Nucl, Sez Pavia, I-27100 Pavia, Italy; Ist Nazl Fis Nucl, Sez Roma Tor Vergata, I-00133 Rome, Italy; Ist Nazl Fis Nucl, Sez Torino, I-10125 Turin, Italy; Natl Res Ctr, Inst Theoret & Expt Phys, Kurchatov Inst, Moscow 117218, Russia; Forschungszentrum Julich, Inst Kernphys, D-52425 Julich, Germany; Kyungpook Natl Univ, Daegu 702701, South Korea; Lamar Univ, 4400 MLK Blvd, Beaumont, TX 77710 USA; MIT, Cambridge, MA 02139 USA; Mississippi State Univ, Mississippi State, MS 39762 USA; Univ New Hampshire, Durham, NH 03824 USA; New Mexico State Univ, Las Cruces, NM 88003 USA; Norfolk State Univ, Norfolk, VA 23504 USA; Ohio Univ, Athens, OH 45701 USA; Old Dominion Univ, Norfolk, VA 23529 USA; Univ Paris Saclay, IJCLab, CNRS IN2P3, F-91405 Orsay, France; Univ Richmond, Richmond, VA 23173 USA; Univ Roma Tor Vergata, I-00133 Rome, Italy; Univ Paris Saclay, IRFU, CEA, F-91191 Gif Sur Yvette, France; Lomonosov Moscow State Univ, Skobeltsyn Nucl Phys Inst, Moscow 119899, Russia; Lomonosov Moscow State Univ, Phys Dept, Moscow 119899, Russia; Univ South Carolina, Columbia, SC 29208 USA; Temple Univ, Philadelphia, PA 19122 USA; Univ Tecn Federico Santa Maria, Casilla 110-V, Valparaiso, Chile; Thomas Jefferson Natl Accelerator Facil, Newport News, VA 23606 USA; Univ Virginia, Charlottesville, VA 22901 USA; Coll William & Mary, Williamsburg, VA 23187 USA; Yerevan Phys Inst, Yerevan 375036, Armenia; Univ York, York YO10 5DD, N Yorkshire, England | Pappalardo, Luciano/AAB-2380-2021; Holtrop, Maurik/A-9017-2010; Burkert, Volker/AAF-7395-2020; Zhang, Jixie/A-1461-2016; Zachariou, Nicholas/R-8360-2018; Jo, Hyon-Suk/HGC-7070-2022; Lee, Sangbaek/MVV-9130-2025; Sabatie, Franck/K-9066-2015; Mascagna, Valerio/HLQ-1103-2023; Adikaram, Dasuni/D-1539-2016; Lanza, Lucilla/E-6479-2017; MacGregor, Ian/D-4072-2011; Mineeva, Taisiya/MDT-1592-2025; Celentano, Andrea/JFJ-2728-2023; Higinbotham, Douglas/J-9394-2014; McKinnon, Bryan/J-2928-2018; Battaglieri, Marco/I-6262-2018; Hyde, Charles/W-9190-2018; Alaoui, Ahmed/B-4638-2015; Sparveris, Nikolaos/C-4751-2008; Costantini, Giulio/F-3829-2018; Marsicano, Luca/KPB-4594-2024; D'Angelo, Annalisa/A-2439-2012; Bozzi, Giuseppe/H-7283-2017; Hakobyan, Hayk/JUF-6461-2023; Filippi, Alessandra/I-9530-2012; Khanal, Aaditya/ABI-5610-2020; Osipenko, Mikhail/N-8292-2015; Deur, Alexandre/H-9778-2019; Filippi, Alessandra/AAE-9322-2020; Ireland, David/E-8618-2010; Schumacher, Reinhard/K-6455-2013; Tyson, Richard/LRC-4125-2024; Isupov, Evgeny/J-2976-2012 | 7005853901; 55828029600; 56047689500; 7004546205; 25823658400; 35277104000; 57221249616; 57210826461; 7006613415; 15755099700; 35226938500; 23033257000; 7004520678; 35277104100; 57605743600; 7102358422; 35227021700; 54398256600; 35277071300; 35725064700; 7005532059; 57203690067; 57218357843; 7004440244; 57221140443; 57214364802; 54392656300; 57202987431; 26663235200; 57189889203; 6603765308; 36022213600; 35227101500; 7003468594; 57221147612; 6602900241; 6507987909; 59345445900; 56272524200; 6604025441; 57217562965; 35374416600; 35069234100; 57193421717; 26535686800; 14041647600; 35227171600; 56978985100; 8695796100; 35227304900; 57215024895; 6603686320; 35227280900; 8258896400; 57210932456; 7102183142; 35225777000; 57217000308; 34570410000; 57208726428; 56115055200; 55382488300; 57206656408; 57214681432; 7005060869; 35227424100; 7006927902; 35227460400; 35227429400; 57202638465; 57216594895; 57208691543; 36604596000; 35227558900; 57204052333; 57205462419; 6701392158; 6507646370; 58375580000; 56273696800; 9278396500; 7006040977; 7004889588; 57193833269; 22135531000; 55751744266; 35227669300; 57224626542; 26023453000; 35227656900; 36169508200; 12244632700; 6603294089; 57212715831; 56530113800; 35227746500; 6701825145; 57226647977; 22986163400; 7004207376; 36085149700; 35227791700; 57208699533; 57385323900; 8903140900; 55329126900; 35227871000; 7004527121; 57219768156; 7003515879; 6701495633; 56589489300; 58092074700; 35227896300; 35228024200; 57212416423; 35227996900; 15030349100; 57213706614; 57217309320; 16065283100; 6507906118; 7004491103; 22969481600; 7004321986; 57203722948; 57222078258; 35228099400; 57223798916; 22136651400; 6504161736; 6603350317; 7201539565; 57221067333; 13204321200; 57222271505; 57201559118; 57204955185; 36836386600; 57215210642; 59819934500 | carman@jlab.org; | PHYSICAL REVIEW C | PHYS REV C | 2469-9985 | 2469-9993 | 105 | 6 | SCIE | PHYSICS, NUCLEAR | 2022 | 3.1 | 34.2 | 0.55 | 2025-06-25 | 5 | 6 | GAMMA-P; LAMBDA; PHOTOPRODUCTION; SIGMA(0); ENERGIES | English | 2022 | 2022-06-01 | 10.1103/physrevc.105.065201 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Development of Brain-Tumor-Targeted Benzothiazole-Based Boron Complex for Boron Neutron Capture Therapy | Boron neutron capture therapy (BNCT) is a precision treatment technology that ideally damages only boron-accumulating cells. The effectiveness of BNCT depends on the amount of boron in the tumor cells and the concentration ratio between normal and tumor tissues. Therefore, for successful brain-tumor treatment using BNCT, it is essential to develop a drug with high blood-brain barrier (BBB) permeability and high tumor accumulation. The benzothiazole-based boron complex 4-(benzo[d]thiazol-2-yl)phenylboronic acid (BTPB) is a hydrophobic, low-molecular-weight compound that has shown high BBB permeability and brain accumulation. The highest boron concentration of BTPB is 36.11 ± 2.73 μg/g (at 1 h post-injection) in the brain, and the highest brain/blood ratio is 3.94 ± 0.46 (at 2 h post-injection), which is sufficient for the BNCT drug condition. In addition, BTPB showed good tumor-targeting ability in vivo in a U87MG glioma tumor model. In this study, we conducted a biological evaluation of BTPB compared to boronophenylalanine as a novel drug for BNCT. © 2022 American Chemical Society. | Yang, Ji-Ung; Kim, Soyeon; Lee, Kyo Chul; Lee, Yong Jin; Kim, Jung Young; Park, Ji-Ae | Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, 01812, South Korea, Department of Medical and Biological Engineering, Kyungpook National University, Daegu, 41566, South Korea; Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, 01812, South Korea, Department of Medical and Biological Engineering, Kyungpook National University, Daegu, 41566, South Korea; Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, 01812, South Korea; Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, 01812, South Korea; Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, 01812, South Korea; Division of Applied RI, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul, 01812, South Korea | 57212217968; 57203773250; 42661704100; 56498070500; 7601371677; 16319690600 | jpark@kirams.re.kr; | ACS Medicinal Chemistry Letters | ACS MED CHEM LETT | 1948-5875 | N/A | 13 | 10 | SCIE | CHEMISTRY, MEDICINAL | 2022 | 4.2 | 34.2 | 0.29 | 2025-06-25 | 3 | BBB; Benzothiazole; BNCT; Boron complex; Tumor targeting | 4 (benzo[d]thiazol 2 yl)phenylboronic acid; 4 boronophenylalanine; benzothiazole derivative; boron derivative; metal complex; unclassified drug; animal experiment; animal model; Article; biological activity; blood brain barrier; boron neutron capture therapy; brain tumor; brain-to-plasma ratio; concentration response; controlled study; drug accumulation; drug blood level; drug brain level; drug cytotoxicity; drug penetration; drug solubility; drug stability; drug structure; drug uptake; effective permeability; glioma; glioma cell line; HEK293 cell line; human; hydrophobicity; IC50; in vivo study; molecular weight; mouse; nonhuman; rat; survival rate | English | Final | 2022 | 10.1021/acsmedchemlett.2c00284 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Hyperpolarization-activated cyclic nucleotide-gated channels working as pacemaker channels in colonic interstitial cells of Cajal | Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels function as pacemaker channels in spontaneously active cells. We studied the existence of HCN channels and their functional roles in the interstitial cells of Cajal (ICC) from the mouse colon using electrophysiological, immunohistochemical and molecular techniques. HCN1 and HCN3 channels were detected in anoctamin-1 (Ca2+-activated Cl- channel; ANO1)-positive cells within the muscular and myenteric layers in colonic tissues. The mRNA transcripts of HCN1 and HCN3 channels were expressed in ANO1-positive ICC. In the deletion of HCN1 and HCN3 channels in colonic ICC, the pacemaking potential frequency was reduced. Basal cellular adenylate cyclase activity was decreased by adenylate cyclase inhibitor in colonic ICC, whereas cAMP-specific phosphodiesterase inhibitors increased it. 8-Bromo-cyclic AMP and rolipram increased spontaneous intracellular Ca2+ oscillations. In addition, Ca2+-dependent adenylate cyclase 1 (AC1) mRNA was detected in colonic ICC. Sulprostone, a PGE(2)-EP3 agonist, increased the pacemaking potential frequency, maximum rate of rise of resting membrane in pacemaker potentials and basal cellular adenylate cyclase activity in colonic ICC. These results indicate that HCN channels exist in colonic ICC and participate in generating pacemaking potentials. Thus, HCN channels may be therapeutic targets in disturbed colonic motility disorders. | Choi, Seok; Seo, Hyunhyo; Lee, Kyungmin; Shin, Dong Hoon; Wu, Mei Jin; Wu, Wenhao; Huang, Xingyou; Zhang, Jingwei; Hong, Chansik; Jun, Jae Yeoul | Chosun Univ, Coll Med, Dept Physiol, 309 Pilmun Daero, Gwangju 61452, South Korea; Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Dept Anat, Daegu, South Korea | ; SEO, Hyunhyo/AAR-6343-2021 | 7408119163; 56611228800; 57211016316; 56643649900; 55992666700; 57219654604; 57219654418; 57357037300; 54957308600; 7202753045 | jyjun@chosun.ac.kr; | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | J CELL MOL MED | 1582-1838 | 1582-4934 | 26 | 2 | SCIE | CELL BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2022 | 5.3 | 34.2 | 0.59 | 2025-06-25 | 6 | 7 | hyperpolarization-activated cyclic nucleotide-gated channels; interstitial cells of Cajal; pacemaker potential | HCN CHANNELS; CURRENTS; CONDUCTANCE; RECEPTOR; EXPRESSION; GENERATE; ROLES; ANO1 | Animals; Colon; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Interstitial Cells of Cajal; Mice; 8 bromo cyclic AMP; 9 (tetrahydro 2 furyl)adenine; adenylate cyclase; anoctamin 1; cyclic AMP phosphodiesterase; hyperpolarization activated cyclic nucleotide gated channel; rolipram; small interfering RNA; sulprostone; hyperpolarization activated cyclic nucleotide gated channel; adult; animal cell; animal experiment; animal model; animal tissue; Article; calcium homeostasis; controlled study; electrophysiology; female; fluorescence imaging; gene expression; genetic transfection; immunofluorescence; immunohistochemistry; immunoreactivity; interstitial cell of Cajal; intestinal dysmotility; male; membrane steady potential; mouse; nonhuman; patch clamp technique; protein expression; reverse transcription polymerase chain reaction; signal transduction; animal; colon; genetics; physiology | English | 2022 | 2022-01 | 10.1111/jcmm.17087 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Measurement of charged-pion production in deep-inelastic scattering off nuclei with the CLAS detector | Background: Energetic quarks in nuclear deep-inelastic scattering propagate through the nuclear medium. Processes that are believed to occur inside nuclei include quark energy loss through medium-stimulated gluon bremsstrahlung and intranuclear interactions of forming hadrons. More data are required to gain a more complete understanding of these effects. Purpose: To test the theoretical models of parton transport and hadron formation, we compared their predictions for the nuclear and kinematic dependence of pion production in nuclei. Methods: We have measured charged-pion production in semi-inclusive deep-inelastic scattering off D, C, Fe, and Pb using the CLAS detector and the CEBAF 5.014-GeV electron beam. We report results on the nuclear-to-deuterium multiplicity ratio for pi(+) and pi(-) as a function of energy transfer, four-momentum transfer, and pion energy fraction or transverse momentum-the first three-dimensional study of its kind. Results: The pi(+) multiplicity ratio is found to depend strongly on the pion fractional energy z and reaches minimum values of 0.67 +/- 0.03, 0.43 +/- 0.02, and 0.27 +/- 0.01 for the C, Fe, and Pb targets, respectively. The z dependencies of the multiplicity ratios for pi(+) and pi(-) are equal within uncertainties for C and Fe targets but show differences at the level of 10% for the Pb-target data. The results are qualitatively described by the GIBUU transport model, as well as with a model based on hadron absorption, but are in tension with calculations based on nuclear fragmentation functions. Conclusions: These precise results will strongly constrain the kinematic and flavor dependence of nuclear effects in hadron production, probing an unexplored kinematic region. They will help to reveal how the nucleus reacts to a fast quark, thereby shedding light on its color structure and transport properties and on the mechanisms of the hadronization process. | Moran, S.; Dupre, R.; Hakobyan, H.; Arratia, M.; Brooks, W. K.; Borquez, A.; El Alaoui, A.; El Fassi, L.; Hafidi, K.; Mendez, R.; Mineeva, T.; Paul, S. J.; Amaryan, M. J.; Angelini, Giovanni; Armstrong, Whitney R.; Atac, H.; Baltzell, N. A.; Barion, L.; Bashkanov, M.; Battaglieri, M.; Bedlinskiy, I.; Benmokhtar, Fatiha; Bianconi, A.; Biondo, L.; Biselli, A. S.; Bossu, F.; Boiarinov, S.; Briscoe, W. J.; Bulumulla, D.; Burkert, V. D.; Carman, D. S.; Chatagnon, P.; Chesnokov, V.; Chetry, T.; Ciullo, G.; Cole, P. L.; Contalbrigo, M.; Costantini, G.; D'Angelo, A.; Dashyan, N.; De Vita, R.; Defurne, M.; Deur, A.; Diehl, S.; Djalali, C.; Egiyan, H.; Elouadrhiri, L.; Eugenio, P.; Fersch, R.; Filippi, A.; Gavalian, G.; Ghandilyan, Y.; Gilfoyle, G. P.; Golubenko, A. A.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Hattawy, M.; Hauenstein, F.; Hayward, T. B.; Heddle, D.; Hicks, K.; Hobart, A.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Isupov, E. L.; Jo, H. S.; Keller, D.; Khanal, A.; Khandaker, M.; Kim, W.; Klein, F. J.; Kripko, A.; Kubarovsky, V.; Kuhn, S. E.; Lanza, L.; Leali, M.; Lenisa, P.; Livingston, K.; MacGregor, I. J. D.; Marchand, D.; Marsicano, L.; Mascagna, V.; McKinnon, B.; McLauchlin, C.; Meziani, Z. E.; Migliorati, S.; Mirazita, M.; Mokeev, V.; Camacho, C. Munoz; Nadel-Turonski, P.; Neupane, K.; Niccolai, S.; Niculescu, G.; O'Connell, T. R.; Osipenko, M.; Ostrovidov, A. I.; Ouillon, M.; Pandey, P.; Paolone, M.; Pappalardo, L. L.; Pasyuk, E.; Phelps, W.; Pogorelko, O.; Poudel, J.; Price, J. W.; Prok, Y.; Raue, B. A.; Reed, Trevor; Ripani, M.; Ritman, J.; Rizzo, A.; Rosner, G.; Rowley, J.; Sabatie, F.; Salgado, C.; Schmidt, A.; Schumacher, R. A.; Sharabian, Y. G.; V. Shirokov, E.; Shrestha, U.; Sokhan, D.; Soto, O.; Sparveris, N.; Stepanyan, S.; Strakovsky, I. I.; Strauch, S.; Tyson, R.; Ungaro, M.; Venturelli, L.; Voskanyan, H.; Vossen, A.; Voutier, E.; Watts, D. P.; Wei, Kevin; Wei, X.; Weinstein, L. B.; Wishart, R.; Wood, M. H.; Yale, B.; Zachariou, N.; Zhang, J.; Zhao, Z. W. | Univ Tecn Federico Santa Maria, Casilla 110-V, Valparaiso, Chile; Univ Paris Saclay, IJCLab, CNRS, IN2P3, F-91405 Orsay, France; Univ Calif Riverside, Riverside, CA 92521 USA; Mississippi State Univ, Mississippi State, MS 39762 USA; Argonne Natl Lab, Argonne, IL 60439 USA; Calif State Univ Dominguez Hills, Carson, CA 90747 USA; Canisius Coll, Buffalo, NY 14208 USA; Carnegie Mellon Univ, Pittsburgh, PA 15213 USA; Catholic Univ Amer, Washington, DC 20064 USA; Univ Paris Saclay, IRFU, CEA, F-91191 Gif Sur Yvette, France; Christopher Newport Univ, Newport News, VA 23606 USA; Univ Connecticut, Storrs, CT 06269 USA; Duke Univ, Durham, NC 27708 USA; Duquesne Univ, Pittsburgh, PA 15282 USA; Fairfield Univ, Fairfield, CT 06824 USA; Univ Ferrara, I-44121 Ferrara, Italy; Florida Int Univ, Miami, FL 33199 USA; Florida State Univ, Tallahassee, FL 32306 USA; George Washington Univ, Washington, DC 20052 USA; INFN, Sez Ferrara, I-44100 Ferrara, Italy; INFN, Lab Nazl Frascati, I-00044 Frascati, Italy; INFN, Sez Genova, I-16146 Genoa, Italy; INFN, Sez Roma Tor Vergata, I-00133 Rome, Italy; INFN, Sez Torino, I-10125 Turin, Italy; INFN, Sez Catania, I-95123 Catania, Italy; INFN, Sez Pavia, I-27100 Pavia, Italy; Inst Kernphys Juelich, Julich, Germany; James Madison Univ, Harrisonburg, VA 22807 USA; Kyungpook Natl Univ, Daegu 41566, South Korea; Lamar Univ, POB 10046, Beaumont, TX 77710 USA; Kurchatov Inst ITEP, Natl Res Ctr, Moscow 117259, Russia; Univ New Hampshire, Durham, NH 03824 USA; New Mexico State Univ, POB 30001, Las Cruces, NM 88003 USA; Norfolk State Univ, Norfolk, VA 23504 USA; Ohio Univ, Athens, OH 45701 USA; Old Dominion Univ, Norfolk, VA 23529 USA; Univ Giessen, Phys Inst 2, D-35392 Giessen, Germany; Rensselaer Polytech Inst, Troy, NY 12180 USA; Univ Richmond, Richmond, VA 23173 USA; Univ Roma Tor Vergata, I-00133 Rome, Italy; Lomonosov Moscow State Univ, Skobeltsyn Inst Nucl Phys, Moscow 119234, Russia; Univ South Carolina, Columbia, SC 29208 USA; Temple Univ, Philadelphia, PA 19122 USA; Thomas Jefferson Natl Accelerator Facil, Newport News, VA 23606 USA; Univ Insubria, I-22100 Como, Italy; Univ Brescia, I-25123 Brescia, Italy; Univ Messina, I-98166 Messina, Italy; Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland; Univ York, York YO10 5DD, N Yorkshire, England; Univ Virginia, Charlottesville, VA 22901 USA; Coll William & Mary, Williamsburg, VA 23187 USA; Yerevan Phys Inst, Yerevan 375036, Armenia; Idaho State Univ, Pocatello, ID 83209 USA | ; Zhang, Jixie/A-1461-2016; Hakobyan, Hayk/JUF-6461-2023; Jo, Hyon-Suk/HGC-7070-2022; Bozzi, Giuseppe/H-7283-2017; Isupov, Evgeny/J-2976-2012; Costantini, Giulio/F-3829-2018; Mineeva, Taisiya/MDT-1592-2025; MacGregor, Ian/D-4072-2011; Alaoui, Ahmed/B-4638-2015; Hyde, Charles/W-9190-2018; mendez, roger/IYS-7526-2023; Mascagna, Valerio/HLQ-1103-2023; Battaglieri, Marco/I-6262-2018; Deur, Alexandre/H-9778-2019; Khanal, Aaditya/ABI-5610-2020; Adikaram, Dasuni/D-1539-2016; Ireland, David/E-8618-2010; Osipenko, Mikhail/N-8292-2015; Sabatie, Franck/K-9066-2015; Schumacher, Reinhard/K-6455-2013; Burkert, Volker/AAF-7395-2020; Filippi, Alessandra/AAE-9322-2020; D'Angelo, Annalisa/A-2439-2012; Sparveris, Nikolaos/C-4751-2008; Tyson, Richard/LRC-4125-2024; Lanza, Lucilla/E-6479-2017; Zachariou, Nicholas/R-8360-2018; McKinnon, Bryan/J-2928-2018; Bashkanov, Mikhail/R-1333-2018; Zhao, Zhi-Wen/HZI-5398-2023; Marsicano, Luca/KPB-4594-2024; Holtrop, Maurik/A-9017-2010; Filippi, Alessandra/I-9530-2012; POUDEL, JIWAN/KQU-6557-2024; Brooks, William/C-8636-2013; Pappalardo, Luciano/AAB-2380-2021 | PHYSICAL REVIEW C | PHYS REV C | 2469-9985 | 2469-9993 | 105 | 1 | SCIE | PHYSICS, NUCLEAR | 2022 | 3.1 | 34.2 | 16 | TRANSVERSE-MOMENTUM; COULOMB DISTORTION; HADRON FORMATION; HADRONIZATION; FRAGMENTATION; PROPAGATION | English | 2022 | 2022-01-12 | 10.1103/physrevc.105.015201 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Polarized structure function σLT′ from π⁰p electroproduction data in the resonance region at 0.4 GeV² < Q² < 1.0 GeV² | The first results on the sigma(LT') structure function in exclusive pi(0)p electroproduction at invariant masses of the final state of 1.5 GeV < W < 1.8 GeV and in the range of photon virtualities 0.4 GeV2 < Q(2) < 1.0 GeV2 were obtained from data on beam spin asymmetries and differential cross sections measured with the CLAS detector at Jefferson Lab. The Legendre moments determined from the sigma(LT') structure function have demonstrated sensitivity to the contributions from the nucleon resonances in the second and third resonance regions. These new data on the beam spin asymmetries in pi(0)p electroproduction extend the opportunities for the extraction of the nucleon resonance electro-excitation amplitudes in the mass range above 1.6 GeV. | Isupov, E. L.; Burkert, V. D.; Golubenko, A. A.; Joo, K.; Markov, N. S.; Mokeev, V., I; Smith, L. C.; Armstrong, W. R.; Atac, H.; Avakian, H.; Baltzell, N. A.; Barion, L.; Battaglieri, M.; Bedlinskiy, I; Benmokhtar, F.; Bianconi, A.; Biondo, L.; Biselli, A. S.; Bondi, M.; Bossu, F.; Briscoe, W. J.; Brooks, W. K.; Bulumulla, D.; Capobianco, R. A.; Carman, D. S.; Carvajal, J. C.; Chatagnon, P.; Chesnokov, V; Ciullo, G.; Cole, P. L.; Clary, B. A.; Contalbrigo, M.; Costantini, G.; D'Angelo, A.; Dashyan, N.; De Vita, R.; Defurne, M.; Deur, A.; Diehl, S.; Djalali, C.; Dupre, R.; Egiyan, H.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fegan, S.; Filippi, A.; Gavalian, G.; Gilfoyle, G. P.; Glazier, D., I; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hattawy, M.; Hayward, T. B.; Heddle, D.; Hicks, K.; Hobart, A.; Holtrop, M.; Illari, I.; Ireland, D. G.; Jenkins, D.; Jo, H. S.; Keller, D.; Khanal, A.; Khandaker, M.; Kim, A.; Kim, W.; Klein, F. J.; Klimenko, V; Kripko, A.; Kubarovsky, V; Lagerquist, V; Lanza, L.; Leali, M.; Lenisa, P.; Livingston, K.; MacGregor, I. J. D.; Marchand, D.; Marsicano, L.; Mascagna, V; McKinnon, B.; Meziani, Z. E.; Migliorati, S.; Mineeva, T.; Mirazita, M.; Camacho, C. Munoz; Nadel-Turonski, P.; Neupane, K.; Niccolai, S.; Osipenko, M.; Pandey, P.; Paolone, M.; Pappalardo, L. L.; Paremuzyan, R.; Pasyuk, E.; Paul, S. J.; Phelps, W.; Pilleux, N.; Pogorelko, O.; Poudel, J.; Price, J. W.; Prok, Y.; Raue, B. A.; Reed, T.; Ripani, M.; Ritman, J.; Rowley, J.; Sabatie, F.; Salgado, C.; Schmidt, A.; Schumacher, R. A.; Sharabian, Y. G.; Shirokov, E., V; Shrestha, U.; Simmerling, P.; Sokhan, D.; Sparveris, N.; Stepanyan, S.; Strakovsky, I. I.; Strauch, S.; Tan, J. A.; Tyson, R.; Ungaro, M.; Vallarino, S.; Venturelli, L.; Voskanyan, H.; Voutier, E.; Watts, D.; Wei, K.; Wei, X.; Wood, M. H.; Yale, B.; Zachariou, N.; Zhang, J.; Ziegler, V | Argonne Natl Lab, Argonne, IL 60439 USA; Calif State Univ Dominguez Hills, Carson, CA 90747 USA; Carnegie Mellon Univ, Pittsburgh, PA 15213 USA; Catholic Univ Amer, Washington, DC 20064 USA; Univ Paris Saclay, IRFU, CEA, F-91191 Gif Sur Yvette, France; Christopher Newport Univ, Newport News, VA 23606 USA; Univ Connecticut, Storrs, CT 06269 USA; Duquesne Univ, 600 Forbes Ave, Pittsburgh, PA 15282 USA; Fairfield Univ, Fairfield, CT 06824 USA; Univ Ferrara, I-44121 Ferrara, Italy; Florida Int Univ, Miami, FL 33199 USA; Florida State Univ, Tallahassee, FL 32306 USA; George Washington Univ, Washington, DC 20052 USA; Ist Nazl Fis Nucl, Sez Ferrara, I-44100 Ferrara, Italy; Ist Nazl Fis Nucl, Lab Nazl Frascati, I-00044 Frascati, Italy; Ist Nazl Fis Nucl, Sez Genova, I-16146 Genoa, Italy; Ist Nazl Fis Nucl, Sez Roma Tor Vergata, I-00133 Rome, Italy; Ist Nazl Fis Nucl, Sez Torino, I-10125 Turin, Italy; Ist Nazl Fis Nucl, Sez Catania, I-95123 Catania, Italy; Ist Nazl Fis Nucl, Sez Pavia, I-27100 Pavia, Italy; Univ Paris Saclay, IJCLab, CNRS IN2P3, F-91405 Orsay, France; Inst Kernphys Juelich, Julich, Germany; Kyungpook Natl Univ, Daegu 41566, South Korea; Lamar Univ, 4400 MLK Blvd,POB 10046, Beaumont, TX 77710 USA; Mississippi State Univ, Mississippi State, MS 39762 USA; Natl Res Ctr, Kurchatov Inst ITEP, Moscow 117259, Russia; Univ New Hampshire, Durham, NH 03824 USA; New Mexico State Univ, POB 30001, Las Cruces, NM 88003 USA; Norfolk State Univ, Norfolk, VA 23504 USA; Ohio Univ, Athens, OH 45701 USA; Old Dominion Univ, Norfolk, VA 23529 USA; Univ Giessen, Phys Inst 2, D-35392 Giessen, Germany; Rensselaer Polytech Inst, Troy, NY 12180 USA; Univ Richmond, Richmond, VA 23173 USA; Univ Roma Tor Vergata, I-00133 Rome, Italy; Lomonosov Moscow State Univ, Skobeltsyn Inst Nucl Phys, Moscow 119234, Russia; Univ South Carolina, Columbia, SC 29208 USA; Temple Univ, Philadelphia, PA 19122 USA; Thomas Jefferson Natl Accelerator Facil, Newport News, VA 23606 USA; Univ Tecn Federico Santa Maria, Casilla 110-V, Valparaiso, Chile; Univ Brescia, I-25123 Brescia, Italy; Univ Messina, I-98166 Messina, Italy; Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland; Univ York, York YO10 5DD, N Yorkshire, England; Virginia Tech, Blacksburg, VA 24061 USA; Univ Virginia, Charlottesville, VA 22901 USA; Coll William & Mary, Williamsburg, VA 23187 USA; Yerevan Phys Inst, Yerevan 375036, Armenia; Univ Calif Riverside, Riverside, CA 92521 USA; Canisius Coll, Buffalo, NY 14208 USA; Lawrence Livermore Natl Lab, Livermore, CA 94550 USA; Idaho State Univ, Pocatello, ID 83209 USA | ; Jo, Hyon-Suk/HGC-7070-2022; Mascagna, Valerio/HLQ-1103-2023; Ireland, David/E-8618-2010; Khanal, Aaditya/ABI-5610-2020; Battaglieri, Marco/I-6262-2018; Tyson, Richard/LRC-4125-2024; Bozzi, Giuseppe/H-7283-2017; McKinnon, Bryan/J-2928-2018; Holtrop, Maurik/A-9017-2010; Alaoui, Ahmed/B-4638-2015; Sabatie, Franck/K-9066-2015; Lanza, Lucilla/E-6479-2017; Sparveris, Nikolaos/C-4751-2008; Mineeva, Taisiya/MDT-1592-2025; Adikaram, Dasuni/D-1539-2016; Costantini, Giulio/F-3829-2018; Schumacher, Reinhard/K-6455-2013; Pappalardo, Luciano/AAB-2380-2021; Osipenko, Mikhail/N-8292-2015; MacGregor, Ian/D-4072-2011; Hakobyan, Hayk/JUF-6461-2023; Burkert, Volker/AAF-7395-2020; Marsicano, Luca/KPB-4594-2024; Brooks, William/C-8636-2013; Filippi, Alessandra/I-9530-2012; Zhang, Jixie/A-1461-2016; Deur, Alexandre/H-9778-2019; Filippi, Alessandra/AAE-9322-2020; D'Angelo, Annalisa/A-2439-2012; Rossi, Patrizia/B-5943-2019; Isupov, Evgeny/J-2976-2012; POUDEL, JIWAN/KQU-6557-2024 | 35227460400; 7004440244; 57210932456; 57202638465; 35227617100; 7004546205; 8115440100; 57221249616; 57210826461; 7006613415; 35226938500; 23033257000; 7004520678; 35277104100; 57218527298; 7102358422; 57226649056; 35227021700; 54398256600; 35725064700; 7005532059; 35400106000; 57218357843; 57221140443; 7005853901; 57214364802; 57202987431; 26663235200; 6603765308; 35227101500; 57202060165; 7003468594; 57221147612; 55828029600; 6507987909; 59345445900; 56272524200; 6604025441; 57217562965; 35374416600; 35069234100; 35227171500; 26535686800; 14041647600; 35227171600; 9845148400; 56978985100; 8695796100; 35227304900; 6603686320; 8258896400; 7102183142; 57217000308; 7003432409; 25948329000; 34570410000; 57208726428; 56115055200; 57206656408; 7003821864; 22966851900; 57214681432; 7005060869; 57214820710; 57209456981; 57237808500; 35227429400; 57216594895; 57208691543; 13405022500; 36604596000; 35227558900; 57214026240; 57204052333; 57205462419; 6701392158; 57200223336; 56047689500; 6507646370; 56273696800; 9278396500; 7006040977; 7004889588; 57193833269; 22135531000; 35227669300; 24500876300; 57224626542; 26023453000; 35227656900; 12244632700; 6603294089; 57212715831; 35227746500; 57197510744; 6701825145; 57226647977; 22986163400; 7004207376; 36085149700; 35227791700; 57208699533; 56362788600; 57385323900; 8903140900; 57200602864; 55329126900; 35227871000; 7004527121; 57219768156; 7003515879; 6701495633; 57214597279; 35227896300; 35228024200; 57198983235; 7201653195; 35227996900; 15030349100; 57213706614; 57217309320; 16065283100; 6507906118; 7004491103; 22969481600; 7004321986; 57200599233; 57222078258; 35228099400; 57223798916; 22136651400; 6504161736; 6603350317; 7201539565; 57221067333; 13204321200; 57201559118; 57204955185; 36836386600; 57215210642; 59819934500 | PHYSICAL REVIEW C | PHYS REV C | 2469-9985 | 2469-9993 | 105 | 2 | SCIE | PHYSICS, NUCLEAR | 2022 | 3.1 | 34.2 | 0.18 | 2025-06-25 | 1 | 2 | NUCLEON | English | 2022 | 2022-02-18 | 10.1103/physrevc.105.l022201 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Radiative proton capture on ¹⁵N within effective field theory | The astrophysical S factor for the radiative proton capture process on the 15N nucleus, i.e., 15N(p, gamma ) 16O, at stellar energies are studied within the framework of the cluster effective field theory. The thermonuclear 15N(p, gamma ) 16O reaction links the type-I to type-II cycles of the carbon-nitrogen-oxygen cycle and affects the abundances of elements in the universe. For investigating this reaction in the effective field theory formalism, we first construct an effective Lagrangian that is appropriate for this reaction at low energies. Since the intermediate excited states of the 16O nucleus have a crucial role in this reaction, we include these resonances in the formalism. The corresponding radiative capture amplitudes and cross section are calculated, which lead to the astrophysical S factor. The low-energy constants introduced in the effective Lagrangian are determined by fitting the theoretical results to the observed S factors in the range of 130 keV < Ep < 2500 keV using three different experimental data sets. Considering the recent data sets, we obtain S(0) = 29.8-34.1 keV b, which is in a good agreement with the estimates from R-matrix approaches in the literature. The values of S at the Gamow energy are found to be larger than S(0) values by about 10%. | Son, Sangyeong; Ando, Shung-Ichi; Oh, Yongseok | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Sunmoon Univ, Dept Display & Semicond Engn, Asan 31460, Chungnam, South Korea; Asia Pacific Ctr Theoret Phys, Pohang 37673, Gyeongbuk, South Korea | 57716853100; 24381529100; 7402125873 | thstkd3754@gmail.com;sando@sunmoon.ac.kr;yohphy@knu.ac.kr; | PHYSICAL REVIEW C | PHYS REV C | 2469-9985 | 2469-9993 | 106 | 5 | SCIE | PHYSICS, NUCLEAR | 2022 | 3.1 | 34.2 | 0.37 | 2025-06-25 | 5 | 4 | NUCLEI; SCATTERING | English | 2022 | 2022-11-18 | 10.1103/physrevc.106.055807 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | A Review on the Role of Endophytes and Plant Growth Promoting Rhizobacteria in Mitigating Heat Stress in Plants | Among abiotic stresses, heat stress is described as one of the major limiting factors of crop growth worldwide, as high temperatures elicit a series of physiological, molecular, and biochemical cascade events that ultimately result in reduced crop yield. There is growing interest among researchers in the use of beneficial microorganisms. Intricate and highly complex interactions between plants and microbes result in the alleviation of heat stress. Plant-microbe interactions are mediated by the production of phytohormones, siderophores, gene expression, osmolytes, and volatile compounds in plants. Their interaction improves antioxidant activity and accumulation of compatible osmolytes such as proline, glycine betaine, soluble sugar, and trehalose, and enriches the nutrient status of stressed plants. Therefore, this review aims to discuss the heat response of plants and to understand the mechanisms of microbe-mediated stress alleviation on a physio-molecular basis. This review indicates that microbes have a great potential to enhance the protection of plants from heat stress and enhance plant growth and yield. Owing to the metabolic diversity of microorganisms, they can be useful in mitigating heat stress in crop plants. In this regard, microorganisms do not present new threats to ecological systems. Overall, it is expected that continued research on microbe-mediated heat stress tolerance in plants will enable this technology to be used as an ecofriendly tool for sustainable agronomy. | Shaffique, Shifa; Khan, Muhammad Aaqil; Wani, Shabir Hussain; Pande, Anjali; Imran, Muhammad; Kang, Sang-Mo; Rahim, Waqas; Khan, Sumera Afzal; Bhatta, Dibya; Kwon, Eun-Hae; Lee, In-Jung | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Shere E Kashmir Univ Agr Sci & Technol Srinagar, Mt Res Ctr Field Crops Khudwani, Anantnag 190025, Jammu & Kashmir, India; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Dept Plant Biosci,Lab Plant Mol Pathol & Funct Ge, Daegu 41944, South Korea; Univ Peshawar, Ctr Biotechnol & Microbiol, Peshawar 45000, Pakistan | Lee, In-Jung/GLS-0432-2022; Kang, Sang-Mo/MBG-7823-2025; Wani, Shabir/B-4599-2014; Imran, Muhammad/AFL-6590-2022; Khan, Muhammad/ABB-9797-2021; Pande, Anjali/ABH-2333-2021; shaffique, shifa/KUC-7102-2024; Khan, Shuhab/C-6839-2008 | 57203898867; 57188585606; 26221990800; 57222624154; 58282433800; 56189696900; 57431774700; 9636646900; 57450591300; 57224398710; 16425830900 | shifa.2021@knu.ac.kr;aqil_bacha@yahoo.com;shabirhwani@skuastkashmir.ac.in;anjali.pande23@gmail.com;m.imran02@yahoo.com;kmoya@hanmail.net;waqasrahim999@yahoo.com;drsumera@uop.edu.pk;divine@knu.ac.kr;eunhaekwon@naver.com;ijlee@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 10 | 7 | SCIE | MICROBIOLOGY | 2022 | 4.5 | 34.4 | 2.68 | 2025-06-25 | 47 | 67 | heat stress; bio stimulant; microbes | BIOLOGICAL NITROGEN-FIXATION; MOLECULAR RESPONSES; TOLERANCE; PHOTOSYNTHESIS; MECHANISMS; DROUGHT; PHYTOHORMONES; STRATEGIES; RESISTANCE; TOMATO | bio stimulant; heat stress; microbes | English | 2022 | 2022-07 | 10.3390/microorganisms10071286 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Androstenone induces horses to be more compliant with human-horse interactions | Olfactory signals play an essential role in communication in animals. Pheromones are volatile or nonvolatile chemicals that trigger social responses among animals. Therefore, pheromone treatment could, in theory, be used to modify horse behavior to improve human-horse relationships. Androstenone (5 alpha-zandrost-16-en-3-one) is a steroidal pheromone found in the saliva of boars and elicits responses across species. However, its role in horse behaviors is not elucidated. This study investigated the effect of androstenone on horse behavior. Trainability (lowering head and moving hindfeet) and calmness tests (standing still with or without a stimulator) were performed with or without applying androstenone diluted with jojoba oil. Treatment with 10 mu g/mL of androstenone applied 30 minute before the tests significantly decreased the time for the horses to lower their head compared with the control. The results of the calmness tests had no significant differences compared with the control group. In the pressure mediation test for trainability assessment, a group of horses treated with 10 mu g/mL of androstenone moved their hind feet in a significantly shorter time (P < 0.05) than the control group. As a result, androstenone appears to induce horses to be more accepting of general management and training. (C) 2021 Published by Elsevier Inc. | Choi, Yeonju; Yoon, Minjung | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju, South Korea; Kyungpook Natl Univ, Dept Horse Compan & Wild Anim Sci, Sangju 37224, South Korea | 57208551604; 22137296500 | mjyoonemail@gmail.com; | JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH | J VET BEHAV | 1558-7878 | 1878-7517 | 48 | SCIE | BEHAVIORAL SCIENCES;VETERINARY SCIENCES | 2022 | 1.8 | 34.4 | 0.65 | 2025-06-25 | 2 | 3 | Androstenone; Behavior; Horses; Pheromone | PIG AGONISTIC BEHAVIOR; PHEROMONE; SENSITIVITY; RESPONSES; INJURIES | Androstenone; Behavior; Horses; Pheromone | androstenone; sex pheromone; unclassified drug; vegetable oil; animal behavior; animal experiment; Article; controlled study; female; foot; gelding; head; horse; human-animal interaction; male; mare; mediation analysis; movement (physiology); nonhuman; pressure; Simmondsia chinensis; training | English | 2022 | 2022-02 | 10.1016/j.jveb.2021.10.007 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Clinical features and management of snake bites in 70 dogs in Korea | Background: Snakebites remain a devastating and life-threatening environmental hazard. While the management of snakebites has been well described in humans, few clinical data and guidelines exist for dogs, especially in Korea. Objectives: This retrospective study evaluated the clinical features of 70 dogs with snakebite wounds in Korea. Methods: The medical records of 72 dogs that presented to three animal hospitals from June 2008 to July 2021 were reviewed; among these, 70 dogs that met the inclusion criteria were enrolled. Their signalment, history, clinical signs, physical examination, blood analysis, treatment, and prognosis were also evaluated. Results: Of 70 dog owners, 35 (50%) witnessed the bite, with a mean time between bite and hospital presentation of 9.7 +/- 4.1 h in 58 dogs. Blood smears were evaluated in 45 dogs, of which 28 (62%) showed echinocytosis. Anemia and acute kidney injury were found in 21 (29%) and 2 dogs (3%), respectively. A total of 37 dogs (53%) were hospitalized, 5 (7%) of which died. Conclusions: The most significant finding was the high prevalence of echinocytosis. The data from this retrospective study could inform the management of dogs bitten by snakes in Korea. | Kim, Dongseok; Kim, Seonghoon; Kim, Jin-Kyung; Lim, Jae Hyun; Choi, Geonho; Bae, Seulgi; Kwon, Young-Sam; Jang, Min | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Surg, 80 Daehak Ro, Daegu 41566, South Korea; Haemaru Referral Anim Hosp, Seongnam 13590, South Korea; Daegu Anim Med Ctr, Daegu 42147, South Korea | 57952302900; 57952303000; 57952958300; 57220918056; 57952520700; 55418865900; 7403459426; 55341507600 | jangmin@knu.ac.kr; | JOURNAL OF VETERINARY SCIENCE | J VET SCI | 1229-845X | 1976-555X | 23 | 6 | SCIE | VETERINARY SCIENCES | 2022 | 1.8 | 34.4 | 0.87 | 2025-06-25 | 1 | 4 | Snakebites; mamushi; echinocytosis; dogs; antivenin | VIPERA-PALAESTINAE ENVENOMATION; RATTLESNAKE ENVENOMATION; RETROSPECTIVE EVALUATION; ANTIVENOM; EFFICACY | Antivenin; Dogs; Echinocytosis; Mamushi; Snakebites | alanine aminotransferase; albumin; antibiotic agent; aspartate aminotransferase; butorphanol; C reactive protein; chlorpheniramine; creatinine; fentanyl; glucocorticoid; glucose; Hartmann solution; hemoglobin; hydromorphone; ketamine; lactic acid; lidocaine; tramadol; venom antiserum; acute kidney failure; anemia; arterial pressure; Article; bleeding; blood analysis; blood cell count; breathing rate; clinical feature; continuous bleeding; cyanosis; dog; echinocytosis; edema; erythema; female; heart rate; hematocrit; hospitalization; Korea; leukocyte count; male; mamushi; mortality; nonhuman; physical examination; platelet count; prognosis; retrospective study; skin turgor; snake; snakebite; snakebite wound; urea nitrogen blood level; wound | English | 2022 | 2022-11 | 10.4142/jvs.22105 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Comparison of blood electrolyte and biochemical parameters between single infections of rotavirus and Cryptosporidium parvum in diarrheic Hanwoo calves | Background: Neonatal calf diarrhea is a major problem in the cattle industry worldwide. Rotavirus and Cryptosporidium parvum are the primary causative agents, especially during the first three weeks of the calf's life. Objectives: This study investigated the differences in acid-base, electrolytes, and biochemical parameters of diarrheic calves with infection of either rotavirus or C. parvum. Methods: A total of 61 Korean native calves (<= 20 days old) were divided into two groups based on rotavirus or C. parvum infections: rotavirus infection (n = 44) and C. parvum infection (n = 17). The calves with at a specific blood pH range (pH 6.92-7.25) were chosen for comparison. The acid-base, electrolyte, chemistry, and serum proteins were analyzed, Further, fecal examinations were performed. Results: Compared to C. parvum-infected calves, the rotavirus-infected calves showed lower levels of total carbon dioxide, bicarbonate (HCO3-), anion gap, total protein, and albumin/globulin ratio, and significantly lower levels of potassium, globulin, and alpha 2-globulin (p < 0.05). The C. parvum-infected calves (r = 0.749) had stronger correlations between pH and HCO3- than the rotavirus-infected calves (r = 0.598). Compared to rotavirus-infected calves, strong correlations between globulin and alpha 2-globulin, alpha 2-globulin and haptoglobin were identified in C. parvum-infected calves. Conclusions: This study is the first to investigate acid-base, electrolyte, and biochemical parameters in calves in response to infections of rotavirus and C. parvum. Although rotavirus and C. parvum cause malabsorptive and secretory diarrhea in similar-aged calves, blood parameters were different. This would help establish the diagnostic and treatment strategies. | Ha, Seungmin; Kang, Seogjin; Park, Kwang-Man; Ku, Ji-Yeong; Choi, Kyoung-Seong; Park, Jinho | Rural Dev Adm, Natl Inst Anim Sci, Cheonan 31000, South Korea; Jeonbuk Natl Univ, Coll Vet Med, Dept Vet Internal Med, 79 Gobong Ro, Iksan 54596, South Korea; Kyungpook Natl Univ, Coll Ecol & Environm Sci, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea | ; Ha, Seungmin/JLM-9299-2023 | 57214258903; 7405686508; 57219435315; 57753895700; 7403949556; 8730126700 | jpark@jbnu.ac.kr; | JOURNAL OF VETERINARY SCIENCE | J VET SCI | 1229-845X | 1976-555X | 23 | 6 | SCIE | VETERINARY SCIENCES | 2022 | 1.8 | 34.4 | 0.43 | 2025-06-25 | 2 | 2 | Diarrhea; electrolyte; serum protein; rotavirus; Cryptosporidium parvum | NEONATAL CALF DIARRHEA; PATHOGENESIS; DIAGNOSIS; RESPONSES; ENTERITIS; PROFILES | Cryptosporidium parvum; Diarrhea; Electrolyte; Rotavirus; Serum protein | albumin; alpha 2 globulin; bicarbonate; carbon dioxide; electrolyte; globulin; haptoglobin; potassium; acid base balance; animal experiment; Article; blood pH; calf (bovine); cattle disease; chemical parameters; comparative study; controlled study; cryptosporidiosis; diarrhea; electrolyte blood level; female; male; nonhuman; protein blood level; Rotavirus infection | English | 2022 | 2022-11 | 10.4142/jvs.22196 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma | It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical analyses for critical diagnostic and cancer stem cell (CSC) markers. To generate a tumor xenograft model, we subsequently transplanted the tissue pieces from the PAC into athymic nude mice. Immunohistochemical examination was performed for diagnostic (TTF-1, Napsin A, and SP-A) and CSC markers (CD44 and CD133). The use of CSC markers together with diagnostic markers can improve the detection and diagnosis of canine primary and metastatic adenocarcinomas. | Tangchang, Warisraporn; Kim, YunHyeok; Oh, Ye-In; Lee, Byung-Woo; Kim, Hyunwook; Yoon, Byungil | Kangwon Natl Univ, Coll Vet Med, Chunchon 24341, South Korea; Kangwon Natl Univ, Inst Vet Sci, Chunchon 24341, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Vet Internal Med, Daegu 41566, South Korea; Biotoxtech, Cheongju 28115, South Korea; Haemaru Anim Hosp, Seongnam 13590, South Korea | 58001989800; 58000902300; 36466903200; 55616542700; 57203629746; 7201805714 | byoon@kangwon.ac.kr; | JOURNAL OF VETERINARY SCIENCE | J VET SCI | 1229-845X | 1976-555X | 23 | 6 | SCIE | VETERINARY SCIENCES | 2022 | 1.8 | 34.4 | 0.22 | 2025-06-25 | 1 | 1 | Canine pulmonary adenocarcinoma; diagnostic markers; immunohistochemistry; stem cell markers; tumor xenograft model | SURFACTANT PROTEIN-A; LUNG-CANCER; CARCINOMAS; NAPSIN; MODELS; KI-67 | Canine pulmonary adenocarcinoma; Diagnostic markers; Immunohistochemistry; Stem cell markers; Tumor xenograft model | CD133 antigen; Hermes antigen; Ki 67 antigen; animal cell; animal experiment; animal tissue; Article; cancer stem cell; controlled study; dog disease; female; immunohistochemistry; immunoreactivity; lung adenocarcinoma; nonhuman; phenotype; primary tumor; Shih Tzu; tumor growth; tumor xenograft | English | 2022 | 2022-11 | 10.4142/jvs.22124 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Linear Frequency Modulation of NbO2-Based Nanoscale Oscillator With Li-Based Electrochemical Random Access Memory for Compact Coupled Oscillatory Neural Network | Oscillatory neural network (ONN)-based classification of clustered data relies on frequency synchronization to injected signals representing input data, showing a more efficient structure than a conventional deep neural network. A frequency tunable oscillator is a core component of the network, requiring energy-efficient, and area-scalable characteristics for large-scale hardware implementation. From a hardware viewpoint, insulator-metal transition (IMT) device-based oscillators are attractive owing to their simple structure and low power consumption. Furthermore, by introducing non-volatile analog memory, non-volatile frequency programmability can be obtained. However, the required device characteristics of the oscillator for high performance of coupled oscillator have not been identified. In this article, we investigated the effect of device parameters of IMT oscillator with non-volatile analog memory on coupled oscillators network for classification of clustered data. We confirmed that linear conductance response with identical pulses is crucial to accurate training. In addition, considering dispersed clustered inputs, a wide synchronization window achieved by controlling the hold voltage of the IMT shows resilient classification. As an oscillator that satisfies the requirements, we evaluated the NbO2-based IMT oscillator with non-volatile Li-based electrochemical random access memory (Li-ECRAM). Finally, we demonstrated a coupled oscillator network for classifying spoken vowels, achieving an accuracy of 85%, higher than that of a ring oscillator-based system. Our results show that an NbO2-based oscillator with Li-ECRAM has the potential for an area-scalable and energy-efficient network with high performance. | Lee, Donguk; Kwak, Myonghoon; Lee, Jongwon; Woo, Jiyong; Hwang, Hyunsang | Pohang Univ Sci & Technol, Ctr Single Atom Based Semicond Device, Dept Mat Sci & Engn, Pohang, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Dague, South Korea | 57212667343; 57190487323; 56347974700; 53985749100; 7403258319 | hwanghs@postech.ac.kr; | FRONTIERS IN NEUROSCIENCE | FRONT NEUROSCI-SWITZ | 1662-453X | 16 | SCIE | NEUROSCIENCES | 2022 | 4.3 | 34.4 | 0.22 | 2025-06-25 | 2 | 2 | oscillatory neural network; coupled oscillator; insulator-metal transition; electro-chemical random access memory; spoken vowel; classification of spoken vowel | classification of spoken vowel; coupled oscillator; electro-chemical random access memory; insulator-metal transition; oscillatory neural network; spoken vowel | lithium; niobium; niobium dioxide; unclassified drug; Article; artificial neural network; computer simulation; conductance; controlled study; data accuracy; data classification; data clustering; electric potential; electrochemical analysis; frequency modulation; impedance; nanobiotechnology; oscillatory neural network; oscillatory potential; product parameters; vowel | English | 2022 | 2022-06-30 | 10.3389/fnins.2022.939687 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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