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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Incorporation of Ammonium Fluoride and Methanol in Carbon Dioxide Clathrate Hydrates and Their Significance for Hydrate-Based Gas Separation | Methanol is known as one of few small molecules that cannot stabilize a solid clathrate hydrate host lattice as a guest molecule in a simple hydrate phase. Recently, it was discovered that water-NH4F solutions can form clathrates consisting of solid solutions of water and NH4F, which have the same structure as the canonical clathrate hydrates. These doped phases were found to be able to incorporate strongly hydrophilic guests such as methanol. As the next step in testing the utility of these novel hydrates, we prepared NH4F-doped clathrates with simple CO2 and binary CO2 + methanol guest molecules and characterized these by powder X-ray diffraction (PXRD), Raman spectroscopy, and molecular dynamics (MD) simulations. From the PXRD analysis, it was confirmed that CO2 interacts more strongly with the NH4F-doped 5(12) cages than the 5(12) cages without dopants. The MD simulations supported the PXRD results by demonstrating a strong interaction between the O atom of CO2 and the dopant NH4+ in the small cages. The incorporation of methanol into the CO2 + methanol clathrates was confirmed by PXRD analysis. With low concentrations of methanol, this guest shows a preference for the 5(12) cages and may serve as a site blocker for the 5(12) cage that normally would be occupied by small molecules such as CH4 and N-2 in hydrate-based gas separation (HGBS) processes. Phase boundary conditions for hydrate stability in CO2-NH4F-CH3OH- water were obtained, and it was determined that a solution of 5 mol % NH4F and 2.2 mol % CH3OH is a reasonable choice for operating an HBGS process. The present findings provide insight into the potential of the NH4F-doped hydrate lattice, aided by quantities of catalytic methanol, for use in HBGS processes. | Kim, Jeongtak; Lee, Byeonggwan; Shin, Kyuchul; Kang, Seong-Pil; Park, Ki Hun; Cha, Minjun; Alavi, Saman; Ripmeester, John A. | Kyungpook Natl Univ, Dept Appl Chem, Daegu 41566, South Korea; Korea Inst Energy Res, Climate Change Res Div, Daejeon 34129, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea; Kangwon Natl Univ, Dept Energy & Resources Engn, Gangwon Do 24341, South Korea; Natl Res Council Canada, Ottawa, ON K1A 0R6, Canada; Univ Ottawa, Dept Chem & Biomol Sci, Ottawa, ON K1N 6N5, Canada | ; Lee, Byeonggwan/HPD-2363-2023; Alavi, Saman/A-1373-2012; Ripmeester, John/G-1950-2011 | 57204511907; 57201269846; 14030501800; 56647158600; 57208240254; 23666652400; 7005887421; 7102709932 | kyuchul.shin@knu.ac.kr; | INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | IND ENG CHEM RES | 0888-5885 | 60 | 30 | SCIE | ENGINEERING, CHEMICAL | 2021 | 4.326 | 36.0 | 0.48 | 2025-07-30 | 10 | 10 | PHASE-EQUILIBRIA; CO2; HYDROGEN; REPLACEMENT; MIXTURES; DIFFRACTION; CAPTURE; CO2/H-2; SPACE; N-2 | Carbon dioxide; Carbon dioxide process; Fluorine compounds; Hydration; Methanol; Molecular dynamics; Molecules; Ammonium fluoride; Clathrate hydrate; Hydrate stabilities; Low concentrations; Molecular dynamics simulations; Powder X-ray diffraction (pXRD); Small molecules; Strong interaction; Gas hydrates | English | 2021 | 2021-08-04 | 10.1021/acs.iecr.1c01423 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Influence of Material Properties on the Damage-Reporting and Self-Healing Performance of a Mechanically Active Dynamic Network Polymer in Coating Applications | We conducted a detailed investigation of the influence of the material properties of dynamic polymer network coatings on their self-healing and damage-reporting performance. A series of reversible polyacrylate urethane networks containing the damage-reporting diarylbibenzofuranone unit were synthesized, and their material properties (e.g., indentation modulus, hardness modulus, and glass-transition temperature) were measured conducting nanoindentation and differential scanning calorimetry experiments. The damage-reporting and self-healing performances of the dynamic polymer network coatings exhibited opposite tendencies with respect to the material properties of the polymer network coatings. Soft polymer network coatings with low glass-transition temperature (similar to 10 degrees C) and indentation hardness (20 MPa) exhibited better self-healing performance (almost 100%) but two times worse damage-reporting properties than hard polymer network coatings with high glass-transition temperature (35 similar to 50 degrees C) and indentation hardness (150 similar to 200 MPa). These features of the dynamic polymer network coatings are unique; they are not observed in elastomers, films, and hydrogels, whereby the polymer networks are bound to the substrate surface. Evidence indicates that controlling the polymer's physical properties is a key factor in designing high-performance self-healing and damage-reporting polymer coatings based on mechanophores. | Son, Da Hae; Kim, Gi Young; Jeong, Ji-Eun; Lee, Sang-Ho; Park, Young Il; Kong, Hoyoul; Cheong, In Woo; Kim, Jin Chul | Korea Res Inst Chem Technol KRICT, Div Specialty & Biobased Chem Technol, Ctr Adv Specialty Chem, Ulsan 44412, South Korea; Kyungpook Natl Univ, Sch Appl Chem, Daegu 41566, South Korea | ; Kim, Kyoung-Sook/A-7768-2017; Lee, Sang-Ho/T-3699-2019 | 57223202891; 57210997221; 56330436800; 58743026900; 55494480300; 57218561550; 7006733373; 56805502600 | sdf1114@krict.re.kr;giyoung@krict.re.kr;jieunj@krict.re.kr;slee@krict.re.kr;ypark@krict.re.kr;hkong2@krict.re.kr;inwoo@knu.ac.kr;jckim81@krict.re.kr; | MOLECULES | MOLECULES | 1420-3049 | 26 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 0.74 | 2025-07-30 | 10 | 10 | polymer coating; dynamic polymer network; mechanophore; self-healing coating; self-reporting polymer | MECHANOCHEMISTRY; COMPOSITES; FORCE | Dynamic polymer network; Mechanophore; Polymer coating; Self-healing coating; Self-reporting polymer | English | 2021 | 2021-05 | 10.3390/molecules26092468 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Investigation of Potential Antioxidant, Thrombolytic and Neuropharmacological Activities of Homalomena aromatica Leaves Using Experimental and In Silico Approaches | The leaves of Homalomena aromatica are traditionally used in Bangladesh for the treatment of different chronic ailments. The purpose of this study was to explore in vitro antioxidant, thrombolytic activities, and in vivo neuropharmacological effects of methanolic extract of Homalomena aromatica (MEHA) leaves. Antioxidant activity of MEHA was assessed by a DPPH free radical scavenging assay and total phenolics content, total flavonoids content were also measured. The thrombolytic activity was determined by percentage of clot lysis and neuropharmacological activities by hole board, tail suspension, forced swimming and elevated plus maze tests. The results showed that the IC50 value of the extract against DPPH was 199.51 mu g/mL. Quantitative analysis displayed higher contents of phenolics and flavonoids (147.71 mg gallic acid equivalent/g & 66.65 mg quercetin equivalent/g dried extract, respectively). The extract also showed a significant clot lysis (33.31%) activity. In case of anxiolytic activity, the elevate plus maze (EPM) test demonstrated an increase in time spent in open arms, and in case of hole board test, the number of head dipping was also significantly increased (p < 0.05). All the test compared with control (1% Tween in water) and standard (diazepam 1 mg/kg), significant dose (200 & 400 mg/kg) dependent anxiolytic activity was found. In antidepressant activity, there was a significant decrease in period of immobility in both test models (tail suspension and forced swimming) (p < 0.05). Moreover, 13 compounds were identified as bioactive, showed good binding affinities to xanthine oxidoreductase, tissue plasminogen activator receptor, potassium channel receptor, human serotonin receptor targets in molecular docking experiments. Furthermore, ADME/T analysis revealed their drug-likeness, likely pharmacological actions and non-toxic upon consumption. Taken together, our finding support the traditional medicinal use of this plant, which may provide a potential source for future drug discovery. | Ali, Md. Sekendar; Sayem, Syed Al Jawad; Habibullah; Quah, Yixian; Lee, Eon-Bee; Birhanu, Biruk Tesfaye; Suk, Kyoungho; Park, Seung-Chun | Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Med, Dept Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Med, Dept Pharmacol, Daegu 41944, South Korea; Int Islamic Univ Chittagong, Dept Pharm, Kumira 4318, Chittagong, Bangladesh; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea | Birhanu, Biruk/F-1622-2017; Lee, Jung Bok/HHZ-3200-2022; Yixian, Quah/ABE-7629-2021; Park, Seung-Chun/AAV-3388-2021 | 57219661221; 57221340236; 57222393508; 55886933200; 57216526135; 56996190000; 7005114595; 7501832396 | alipharm2000@gmail.com;aljawadsayem@gmail.com;habibmahirbd@gmail.com;im.yixianquah@gmail.com;eonbee@gmail.com;btbtes@gmail.com;ksuk@knu.ac.kr;parksch@knu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 26 | 4 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 0.9 | 2025-07-30 | 11 | 15 | H; aromatica; antioxidant; thrombolytic; anxiolytic; antidepressant; essential oil; molecular docking; ADME profiling | OXIDATIVE STRESS; ESSENTIAL OILS; VEGETABLE INTAKE; DOUBLE-BLIND; ANXIETY; POLYPHENOLS; BEHAVIOR; PHENOLS; HEALTH; FRUIT | ADME profiling; Antidepressant; Antioxidant; Anxiolytic; Essential oil; H. aromatica; Molecular docking; Thrombolytic | Animals; Antidepressive Agents; Antioxidants; Araceae; Biphenyl Compounds; Computer Simulation; Fibrin Clot Lysis Time; Fibrinolytic Agents; Flavonoids; Free Radical Scavengers; Humans; Mice; Molecular Docking Simulation; Neuropharmacology; Phenols; Picrates; Plant Extracts; Plant Leaves; Receptors, Serotonin; Serotonin Antagonists; Swimming; 1,1-diphenyl-2-picrylhydrazyl; antidepressant agent; antioxidant; biphenyl derivative; fibrinolytic agent; flavonoid; phenol derivative; picric acid; plant extract; scavenger; serotonin antagonist; serotonin receptor; animal; Araceae; chemistry; computer simulation; euglobulin lysis test; human; molecular docking; mouse; neuropharmacology; plant leaf; swimming | English | 2021 | 2021-02 | 10.3390/molecules26040975 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Melatonin Ameliorates Thermotolerance in Soybean Seedling through Balancing Redox Homeostasis and Modulating Antioxidant Defense, Phytohormones and Polyamines Biosynthesis | Global warming is impacting the growth and development of economically important but sensitive crops, such as soybean (Glycine max L.). Using pleiotropic signaling molecules, melatonin can relieve the negative effects of high temperature by enhancing plant growth and development as well as modulating the defense system against abiotic stresses. However, less is known about how melatonin regulates the phytohormones and polyamines during heat stress. Our results showed that high temperature significantly increased ROS and decreased photosynthesis efficiency in soybean plants. Conversely, pretreatment with melatonin increased plant growth and photosynthetic pigments (chl a and chl b) and reduced oxidative stress via scavenging hydrogen peroxide and superoxide and reducing the MDA and electrolyte leakage contents. The inherent stress defense responses were further strengthened by the enhanced activities of antioxidants and upregulation of the expression of ascorbate-glutathione cycle genes. Melatonin mitigates heat stress by increasing several biochemicals (phenolics, flavonoids, and proline), as well as the endogenous melatonin and polyamines (spermine, spermidine, and putrescine). Furthermore, the positive effects of melatonin treatment also correlated with a reduced abscisic acid content, down-regulation of the gmNCED3, and up-regulation of catabolic genes (CYP707A1 and CYP707A2) during heat stress. Contrarily, an increase in salicylic acid and up-regulated expression of the defense-related gene PAL2 were revealed. In addition, melatonin induced the expression of heat shock protein 90 (gmHsp90) and heat shock transcription factor (gmHsfA2), suggesting promotion of ROS detoxification via the hydrogen peroxide-mediated signaling pathway. In conclusion, exogenous melatonin improves the thermotolerance of soybean plants and enhances plant growth and development by activating antioxidant defense mechanisms, interacting with plant hormones, and reprogramming the biochemical metabolism. | Imran, Muhammad; Khan, Muhammad Aaqil; Shahzad, Raheem; Bilal, Saqib; Khan, Murtaza; Yun, Byung-Wook; Khan, Abdul Latif; Lee, In-Jung | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Univ Haripur, Dept Hort, Haripur 22620, Pakistan; Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa 616, Oman; Univ Houston, Coll Technol, Dept Engn Technol, Houston, TX 77479 USA | ; Lee, In-Jung/GLS-0432-2022; Khan, Abdul/H-5910-2011; Shahzad, Raheem/AAG-8370-2019; Khan, Muhammad/ABB-9797-2021; Imran, Muhammad/AFL-6590-2022 | 58282433800; 57188585606; 56454250900; 57031617400; 57207990116; 8245123600; 26639372800; 16425830900 | m.imran02@yahoo.com;aqil_bacha@yahoo.com;raheemshehzad@ymail.com;saqib@unizwa.edu.om;murtazakhan.bio@gmail.com;bwyun@knu.ac.kr;alkhan@uh.edu;ijlee@knu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 26 | 17 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 5.83 | 2025-07-30 | 71 | 81 | melatonin; polyamine; antioxidant; abscisic acid; salicylic acid; soybean; heat tolerance | OXIDATIVE STRESS; NITRIC-OXIDE; HEAT-STRESS; METABOLISM; GROWTH; ACID; EXPRESSION; ACCUMULATION; SENESCENCE; SYSTEMS | Abscisic acid; Antioxidant; Heat tolerance; Melatonin; Polyamine; Salicylic acid; Soybean | Abscisic Acid; Antioxidants; Down-Regulation; Gene Expression Regulation, Plant; Glutathione; Heat-Shock Response; Homeostasis; Melatonin; Oxidation-Reduction; Oxidative Stress; Photosynthesis; Plant Growth Regulators; Plant Proteins; Polyamines; Seedlings; Signal Transduction; Soybeans; Stress, Physiological; Thermotolerance; Up-Regulation; abscisic acid; antioxidant; glutathione; melatonin; phytohormone; plant protein; polyamine; down regulation; drug effect; gene expression regulation; heat shock response; heat tolerance; homeostasis; metabolism; oxidation reduction reaction; oxidative stress; photosynthesis; physiological stress; seedling; signal transduction; soybean; upregulation | English | 2021 | 2021-09 | 10.3390/molecules26175116 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Molecular Regulation of Betulinic Acid on α3β4 Nicotinic Acetylcholine Receptors | Betulinic acid (BA) is a major constituent of Zizyphus seeds that have been long used as therapeutic agents for sleep-related issues in Asia. BA is a pentacyclic triterpenoid. It also possesses various anti-cancer and anti-inflammatory effects. Current commercially available sleep aids typically use GABAergic regulation, for which many studies are being actively conducted. However, few studies have focused on acetylcholine receptors that regulate wakefulness. In this study, we utilized BA as an antagonist of alpha 3 beta 4 nicotinic acetylcholine receptors (alpha 3 beta 4 nAChRs) known to regulate rapid-eye-movement (REM) sleep and wakefulness. Effects of BA on alpha 3 beta 4 nAChRs were concentration-dependent, reversible, voltage-independent, and non-competitive. Site-directed mutagenesis and molecular-docking studies confirmed the binding of BA at the molecular level and showed that the alpha 3 subunit L257 and the beta 4 subunit I263 residues affected BA binding. These data demonstrate that BA can bind to a binding site different from the site for the receptor's ligand, acetylcholine (ACh). This suggests that BA may be an effective antagonist that is unaffected by large amounts of ACh released during wakefulness and REM sleep. Based on the above experimental results, BA is likely to be a therapeutically useful sleep aid and sedative. | Lee, Shinhui; Jung, Woog; Eom, Sanung; Yeom, Hye Duck; Park, Heui-Dong; Lee, Junho H. | Chonnam Natl Univ, Dept Biotechnol, Gwangju 61186, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; GoPath Labs, Buffalo Grove, IL 60089 USA | Lee, Junseong/T-4139-2017; Lee, Jun/AAI-1007-2020 | 57210647753; 57222381083; 57195804232; 57189520740; 7601568590; 57189521666 | dltlstn39@gmail.com;crazycell79@nate.com;yeomself2355@gmail.com;hyeduck@gmail.com;hpark@knu.ac.kr;leejunho@chonnam.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 26 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 0.25 | 2025-07-30 | 3 | 3 | α 3β 4 nAChR; betulinic acid; insomnia; sleep regulation; TEVC; Zizyphus seed | BLOOD-BRAIN-BARRIER; ZIZIPHUS-JUJUBA; SLEEP; RELEASE; WAKEFULNESS | 3β4 nAChR; Betulinic acid; Insomnia; Sleep regulation; TEVC; Zizyphus seed | Acetylcholine; Animals; Binding Sites; Cattle; Electrophysiology; gamma-Aminobutyric Acid; Ligands; Molecular Docking Simulation; Mutagenesis; Mutation; Oocytes; Pentacyclic Triterpenes; Protein Binding; Protein Conformation; Protein Subunits; Receptors, Nicotinic; Seeds; Sleep; Sleep Initiation and Maintenance Disorders; Transcription, Genetic; Triterpenes; Xenopus laevis; Ziziphus; 4 aminobutyric acid; acetylcholine; betulic acid; ligand; nicotinic receptor; nicotinic receptor alpha3beta4; pentacyclic triterpene; protein binding; triterpene; animal; binding site; bovine; chemistry; cytology; electrophysiology; genetic transcription; insomnia; metabolism; molecular docking; mutagenesis; mutation; oocyte; plant seed; protein conformation; protein subunit; sleep; Xenopus laevis; Ziziphus | English | 2021 | 2021-05 | 10.3390/molecules26092659 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice | Memory deterioration in Alzheimer's disease (AD) is thought to be underpinned by aberrant amyloid beta (A beta) accumulation, which contributes to synaptic plasticity impairment. Avenanthramide-C (Avn-C), a polyphenol compound found predominantly in oats, has a range of biological properties. Herein, we performed methanolic extraction of the Avns-rich fraction (Fr. 2) from germinated oats using column chromatography, and examined the effects of Avn-C on synaptic correlates of memory in a mouse model of AD. Avn-C was identified in Fr. 2 based on H-1-NMR analysis. Electrophysiological recordings were performed to examine the effects of Avn-C on the hippocampal long-term potentiation (LTP) in a Tg2576 mouse model of AD. Avn-C from germinated oats restored impaired LTP in Tg2576 mouse hippocampal slices. Furthermore, Avn-C-facilitated LTP was associated with changes in the protein levels of phospho-glycogen synthase kinase-3 beta (p-GSK3 beta-S9) and cleaved caspase 3, which are involved in A beta-induced synaptic impairment. Our findings suggest that the Avn-C extract from germinated oats may be beneficial for AD-related synaptic plasticity impairment and memory decline. | Lee, Yu-Young; Wang, Ming; Son, Yurim; Yang, Eun-Ju; Kang, Moon-Seok; Kim, Hyun-Joo; Kim, Hyung-Seok; Jo, Jihoon | Rural Dev Adm, Dept Cent Area, Natl Inst Crop Sci, Suwon 16429, South Korea; Chonnam Natl Univ Med Sch, Dept Biomed Sci, Gwangju 501757, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, 80 Daehak Ro, Daegu 41566, South Korea; Chonnam Natl Univ Med Sch, Dept Forens Med, Gwangju 501757, South Korea; Chonnam Natl Univ, Ctr Creat Biomed Scientists, Med Sch, Gwangju 501757, South Korea | WANG, MING/ABC-2861-2021 | 55042261500; 57209397504; 57201853631; 57191204368; 57222404097; 55931099900; 56739347400; 10439910300 | leeyy260@korea.kr;Ming322@jnu.ac.kr;yurim1023@gmail.com;ejy125@gmail.com;gr27@korea.kr;tlrtod@korea.kr;veritas@chonnam.ac.kr;Jihoon.Jo@jnu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 26 | 20 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 0.33 | 2025-07-30 | 2 | 5 | memory; Alzheimer's disease; avenanthramide-C; polyphenol; oats; hippocampal synaptic plasticity; amyloid beta | ALZHEIMERS-DISEASE; ANTIOXIDANT ACTIVITIES; MOUSE MODEL; A-BETA(1-42); POLYPHENOLS; ACTIVATION; PATHOLOGY; DEFICITS; NEURONS; GROWTH | Alzheimer’s disease; Amyloid β; Avenanthramide-C; Hippocampal synaptic plasticity; Memory; Oats; Polyphenol | Alzheimer Disease; Animals; Avena; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Hippocampus; Long-Term Potentiation; Male; Mice; Mice, Transgenic; Neuronal Plasticity; ortho-Aminobenzoates; Plant Extracts; anthranilic acid derivative; avenanthramide-2C; glycogen synthase kinase 3beta; Gsk3b protein, mouse; plant extract; Alzheimer disease; animal; Avena; chemistry; disease model; drug effect; hippocampus; long term potentiation; male; metabolism; mouse; nerve cell plasticity; pathology; physiology; transgenic mouse | English | 2021 | 2021-10 | 10.3390/molecules26206105 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Status of antimicrobial stewardship programmes in Korean hospitals including small to medium-sized hospitals and the awareness and demands of physicians: a nationwide survey in 2020 | Objectives: This study aimed to identify the status of antimicrobial stewardship programmes (ASPs) in small to medium-sized Korean hospitals as well as the awareness and demands about ASPs of physicians. Methods: A questionnaire was designed based on a questionnaire from a previous nationwide survey in 2018 targeting large hospitals in Korea and modified to reflect the results of in-depth interviews with non-infectious diseases (IDs) physicians at secondary care hospitals. The survey targeted all hospitals with >= 150 beds in South Korea and was performed in May-June 2020. Only one ASP-associated physician per hospital participated in the survey. Results: The survey response rate was 31.9% (217/680). ID specialists comprised the majority of medical personnel participating in ASPs in tertiary care hospitals. Conversely, in secondary and primary care hospitals there was no predominant medical personnel for ASPs and the median full-time equivalent was 0 for all types of medical personnel. Tertiary care hospitals, more than secondary and primary care hospitals, tended to perform ASP activities more actively. 'Workforce for ASPs', 'Establishment of healthcare fees for ASPs' and 'Development of tools for ASPs' were the most important required support for ASP improvement. Conclusion: The level of ASP establishment was more limited in primary care hospitals than in secondary and tertiary care hospitals in Korea. To improve ASPs in Korean hospitals, a supporting workforce and the establishment of a healthcare fee for ASPs appear to be necessary. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) | Lee, Myung Jin; Moon, Song Mi; Kim, Bongyoung; Park, Se Yoon; Park, Ji Young; Koo, Hyunsook; Lee, Hyungmin; Song, Kyoung-Ho; Lee, Hyunju; Park, Jeong Su; Lee, Mi Suk; Choi, Su-Mi; Kim, Chung-Jong; Chang, Hyun-Ha; Kim, Tae Hyong; Park, Sun Hee; Kim, Eu Suk; Kim, Hong Bin | Inje Univ, Dept Internal Med, Sanggye Paik Hosp, Seoul, South Korea; Hallym Univ, Div Infect Dis, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; Hanyang Univ, Dept Internal Med, Coll Med, 222-1 Wangsimni Ro, Seoul 04763, South Korea; Soonchunhyang Univ, Div Infect Dis, Dept Internal Med, Seoul Hosp,Coll Med, Seoul, South Korea; Chung Ang Univ Hosp, Dept Pediat, Seoul, South Korea; Korea Dis Control & Prevent Agcy, Bur Healthcare Safety & Immunizat, Div Healthcare Associated Infect Control, Cheongju, South Korea; Korea Dis Control & Prevent Agcy, Bur Healthcare Safety & Immunizat, Div Antimicrobial Resistance Control, Cheongju, South Korea; Seoul Natl Univ Coll, Div Infect Dis, Dept Internal Med, Bundang Hosp,Coll Med, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, Gyeonggi Do, South Korea; Seoul Natl Univ, Dept Pediat, Bundang Hosp, Coll Med, Seongnam, South Korea; Seoul Natl Univ, Dept Lab Med, Bundang Hosp, Coll Med, Seongnam, South Korea; Kyung Hee Univ, Div Infect Dis, Dept Internal Med, Sch Med, Seoul, South Korea; Catholic Univ Korea, Div Infect Dis, Dept Internal Med, Coll Med, Seoul, South Korea; Ewha Womans Univ, Div Infect Dis, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Div Infect Dis, Dept Internal Med, Daegu, South Korea | ; Kim, Sooyeon/AAA-8521-2022; Park, Jeong/L-7584-2019; Kim, Hee/AAU-6368-2021; Kim, Hong Bin/J-5452-2012; Park, Ji Young/KDO-4256-2024; Kim, Woo/AAG-1822-2019; Kim, Eu/J-5424-2012; Kim, Tae Hyong/L-7336-2015 | 55520467500; 36554757200; 55622077200; 55259986400; 57022396700; 58603330800; 55745172400; 23398486700; 26322997700; 35082469500; 55759244100; 7408120168; 45361165100; 7407521688; 55927274000; 57208684295; 22938086900; 35307429400 | sobakas@hanyang.ac.kr;eskim@snubh.org; | JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | J GLOB ANTIMICROB RE | 2213-7165 | 2213-7173 | 26 | SCIE | INFECTIOUS DISEASES;PHARMACOLOGY & PHARMACY | 2021 | 4.349 | 36.0 | 0.88 | 2025-07-30 | 12 | 13 | Antibiotics; Stewardship; Resistance; Infectious diseases; Korea | INFECTIOUS-DISEASES-SOCIETY; ANTIBIOTIC STEWARDSHIP; EPIDEMIOLOGY | Antibiotics; Infectious diseases; Korea; Resistance; Stewardship | Anti-Bacterial Agents; Antimicrobial Stewardship; Hospitals; Humans; Physicians; Republic of Korea; Surveys and Questionnaires; amikacin; antibiotic agent; gentamicin; vancomycin; antiinfective agent; antimicrobial stewardship; Article; awareness; human; internist; medical care need; physician; questionnaire; secondary care center; South Korea; tertiary care center; hospital | English | 2021 | 2021-09 | 10.1016/j.jgar.2021.06.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synthesis and α-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl]-N-arylacetamides: An In Silico and Biochemical Approach | Diabetes mellitus (DM) is a chronic disorder and has affected a large number of people worldwide. Insufficient insulin production causes an increase in blood glucose level that results in DM. To lower the blood glucose level, various drugs are employed that block the activity of the alpha-glucosidase enzyme, which is considered responsible for the breakdown of polysaccharides into monosaccharides leading to an increase in the intestinal blood glucose level. We have synthesized novel 2-(3-(benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-arylacetamides and have screened them for their in silico and in vitro alpha-glucosidase inhibition activity. The derivatives 11c, 12a, 12d, 12e, and 12g emerged as potent inhibitors of the alpha-glucosidase enzyme. These compounds exhibited good docking scores and excellent binding interactions with the selected residues (Asp203, Asp542, Asp327, His600, Arg526) during in silico screening. Similarly, these compounds also showed good in vitro alpha-glucosidase inhibitions with IC50 values of 30.65, 18.25, 20.76, 35.14, and 24.24 mu M, respectively, which were better than the standard drug, acarbose (IC50 = 58.8 mu M). Furthermore, a good agreement was observed between in silico and in vitro modes of study. | Saddique, Furqan Ahmad; Aslam, Sana; Ahmad, Matloob; Ashfaq, Usman Ali; Muddassar, Muhammad; Sultan, Sadia; Taj, Saman; Hussain, Muzammil; Sung Lee, Dae; Zaki, Magdi E. A. | Govt Coll Univ, Dept Chem, Faisalabad 38000, Pakistan; Govt Coll Women Univ, Dept Chem, Faisalabad 38000, Pakistan; Govt Coll Univ, Dept Bioinformat & Biotechnol, Faisalabad 38000, Pakistan; COMSATS Univ Islamabad, Dept Biosci, Pk Rd, Islamabad 45500, Pakistan; Univ Teknol MARA, Fac Pharm, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; Univ Teknol MARA, Attaur ur Rahman Inst Nat Prod Discovery AuRIns, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Imam Mohammad Ibn Saud Islamic Univ IMSIU, Dept Chem, Fac Sci, Riyadh 11623, Saudi Arabia | Zaki, Magdi/Z-6019-2019; Aslam, Sana/AAG-7250-2019; Ashfaq, Prof.Dr. Usman Ali/D-7792-2013; Ahmad, Matloob/AGT-5024-2022; Ashfaq, Usman/D-7792-2013; Sultan, Sadia/ABA-9397-2021; AHMAD, MATLOOB/AGT-5024-2022 | 57189264877; 36156928200; 56289725300; 36930000500; 57201969978; 8845660300; 57209455210; 58279975000; 55568524907; 7202243779 | furqanas123@gmail.com;Dr.Sana@gcwuf.edu.pk;Matloob.Ahmad@gcuf.edu.pk;ashfaqua@gcuf.edu.pk;mmuddassar@comsats.edu.pk;drsadia@uitm.edu.my;saman20220@yahoo.com;muzammil@knu.ac.kr;daesung@knu.ac.kr;mezaki@imamu.edu.sa; | MOLECULES | MOLECULES | 1420-3049 | 26 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 1.31 | 2025-07-30 | 16 | 17 | 1,2-Benzothiazines; synthesis; molecular docking; alpha-glucosidase inhibition; anti-diabetic | MICROWAVE-ASSISTED SYNTHESIS; MOLECULAR DOCKING; POTENT INHIBITORS; CYCLICSULFONAMIDE DERIVATIVES; POSTPRANDIAL HYPERGLYCEMIA; ANTIMICROBIAL ACTIVITY; RISK-FACTORS; LIFE-STYLE; EXTRACT; DISCOVERY | 1,2-Benzothiazines; Anti-diabetic; Molecular docking; Synthesis; α-glucosidase inhibition | Acetamides; Computer Simulation; Diabetes Mellitus; Drug Evaluation, Preclinical; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Inhibitory Concentration 50; Molecular Docking Simulation; Structure-Activity Relationship; Thiazines; acetamide derivative; antidiabetic agent; glycosidase inhibitor; thiazine derivative; chemistry; computer simulation; diabetes mellitus; human; IC50; molecular docking; preclinical study; structure activity relation; synthesis | English | 2021 | 2021-05 | 10.3390/molecules26103043 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article; Proceedings Paper | A Supply Voltage Noise Immunity Enhancement Design for High-Voltage Gate Driver IC Based on Bootstrap Circuit | One important design aspect of a high-voltage gate driver integrated circuit (HVIC) is safety because the failure operation such as latch-on failure may cause severe damage to the system and may pose physical harm to the user. In the HVIC, a noise on the high-side supply voltage was considered as the main source of failure operation, however, a low-side supply voltage noise also can cause latch-on failure to the high-side circuitry. In this brief, the failure caused by the high-side as well as low-side supply voltage noise is analyzed, and a supply voltage noise immunity enhancement design for HVIC is described. The HVIC has been implemented in a 1.2 mu m 600 V BCDMOS process. The proposed design shows a latch-on free operation from the various slope of the supply voltage drops while the conventional design shows shoot-through failure by latch-on failure. The approach is well suited for the harsh supply voltage environment such as the automotive application. | Jin, Wookang; Cho, Kunhee | ON Semicond, Adv Solut Grp, Phoenix, AZ 85008 USA; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea | 55598216100; 57069360800 | kunhee@knu.ac.kr; | IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS | IEEE T CIRCUITS-II | 1549-7747 | 1558-3791 | 68 | 9 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2021 | 3.691 | 36.1 | 0.49 | 2025-07-30 | 6 | 8 | High voltage gate driver; HVIC; noise immunity; latch-on failure; bootstrap circuit; short-pulse generator; automotive | automotive; bootstrap circuit; High voltage gate driver; HVIC; latch-on failure; noise immunity; short-pulse generator | Flip flop circuits; Integrated circuits; Timing circuits; Automotive applications; Bootstrap circuits; Conventional design; High sides; High voltage gates; Shoot-through; Supply voltages; Integrated circuit design | English | 2021 | 2021-09 | 10.1109/tcsii.2021.3087596 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Outcomes of Remote Patient Monitoring for Automated Peritoneal Dialysis: A Randomized Controlled Trial | Introduction: We hypothesize that remote patient monitoring (RPM) for automated peritoneal dialysis (APD) and feedback could enhance patient self-management and improve outcomes. The aim of this study was to evaluate the efficacy of RPM-APD compared to traditional APD (T-APD) without RPM. Methods: In this multicenter, randomized controlled trial, patients on APD were randomized to T-APD (n = 29) or RPM-APD (n = 28) at 12 weeks and followed until 25 weeks. Health-related quality of life (HRQOL), patient and medical staff satisfaction with RPM-APD, and dialysis-related outcomes were compared between the 2 groups. Results: We found no significant differences in HRQOL scores at the time of enrollment and randomization between RPM-APD and T-APD. At the end of the study, the RPM-APD group showed better HRQOL for the sleep domain (p = 0.049) than the T-APD group and the T-APD group showed better HRQOL for the sexual function domain (p = 0.030) than the RPM-APD group. However, we found no significant interactions between the time and groups in terms of HRQOL. Different HRQOL domains significantly improved over time in patients undergoing RPM-APD (effects of kidney disease, p = 0.025) and T-APD (burden of kidney disease, p = 0.029; physical component summary, p = 0.048). Though medical staff satisfaction with RPM-APD was neutral, most patients were quite satisfied with RPM-APD (median score 82; possible total score 105 on 21 5-item scales) and the rating scores were maintained during the study period. We found no significant differences in dialysis adherence, accuracy, adequacy, overhydration status, blood pressure, or the number of unplanned visits between the 2 groups. Discussion/Conclusion: Although HRQOL and dialysis-related outcomes were comparable between RPM-APD and T-APD, RPM-APD was positive in terms of patient satisfaction. Further long-term and large-scale studies will be required to determine the efficacy of RPM-APD. | Jung, Hee-Yeon; Jeon, Yena; Kim, Yon Su; Kim, Dong Ki; Lee, Jung Pyo; Yang, Chul Woo; Ko, Eun Jeong; Ryu, Dong-Ryeol; Kang, Shin-Wook; Park, Jung Tak; Lim, Jeong-Hoon; Choi, Ji-Young; Cho, Jang-Hee; Kim, Chan-Duck; Kim, Yong-Lim; Park, Sun-Hee | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul, South Korea; Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea | Park, Sun-Hee/LMN-0033-2024; Kim, Dong Ki/J-5389-2012; Lim, Jeong-Hoon/ABE-6003-2020; Cho, Jang-hee/ABD-3534-2020; Lee, Jun-Young/N-5963-2019; Kim, Yong-Lim/AGK-3172-2022; Jung, Hee-Yeon/AFB-8578-2022; Kim, Eun/AAS-6706-2020 | 57196396467; 57209909350; 7410205767; 23479259100; 56028990400; 7407743404; 57194720455; 56669926200; 34768359700; 15036313100; 55360244300; 7501393222; 7403536291; 8558530700; 55633533600; 7501831741 | ylkim@knu.ac.kr;sh-park@knu.ac.kr; | NEPHRON | NEPHRON | 1660-8151 | 2235-3186 | 145 | 6 | SCIE | UROLOGY & NEPHROLOGY | 2021 | 3.457 | 36.1 | 0.94 | 2025-07-30 | 14 | 12 | Remote patient monitoring; Automated peritoneal dialysis; Quality of life; Satisfaction; Randomized controlled trial | QUALITY-OF-LIFE; SURVIVAL | Automated peritoneal dialysis; Quality of life; Randomized controlled trial; Remote patient monitoring; Satisfaction | Adult; Automation; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Monitoring, Physiologic; Patient Satisfaction; Peritoneal Dialysis; Prospective Studies; Quality of Life; Telemedicine; adult; Article; blood pressure; clinical article; cognition; continuous ambulatory peritoneal dialysis; controlled study; disease burden; female; follow up; human; kidney disease; male; medical staff; middle aged; multicenter study; outcome assessment; patient satisfaction; peritoneal dialysis; peritonitis; prospective study; quality of life; randomized controlled trial; satisfaction; sexual function; sleep; social interaction; social support; telemonitoring; automation; chronic kidney failure; clinical trial; pathophysiology; peritoneal dialysis; physiologic monitoring; procedures; telemedicine | English | 2021 | 2021-11 | 10.1159/000518364 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Properties of Yb-added ZnO (Yb:ZnO) films as an energy-conversion layer on polycrystalline silicon solar cells | Yb-added ZnO (Yb:ZnO) films, as an energy-conversion layer, were formed using a spin-coating technique. Asformed Yb:ZnO films mainly showed the wurtzite structural ZnO phase and a cubic structural Yb2O3 phase appeared at the annealing temperature of 750 ?C. The formation route of Yb:ZnO films was proposed as follows: Yb elements did not incorporate into the ZnO host, because of the large difference in ionic radii and the oxidation state of Zn2+ and Yb3+ ions. Thus, diffused Yb elements in the ZnO grains were crystallized independently in the grains during annealing process. The energy-transfer process from the ZnO host to the Yb2O3 nanocomposites occurred efficiently, and the mechanism was followed by a quantum cutting process. The improvement ratio of the power conversion efficiency for the Yb:ZnO-formed glass/pc-Si solar cell (11.7%) compared to that for the bare-glass/pc-Si cell (10.7%) was approximately 9%. Thus, the Yb:ZnO films could be used as an effective energy-conversion layer for Si-solar cells with the benefit of very simple and inexpensive processing. | Kim, Hong Tak; Lee, Sung-Youp; Slaoui, Abdelilah; Dinia, Aziz; Jeon, Hye Jun; Park, Chinho | Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Univ Strasbourg, ICube, CNRS, 23 Rue Loess, F-67037 Strasbourg, France; Univ Strasbourg, IPCMS, CNRS, 23 Rue Loess, F-67037 Strasbourg, France; Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea | aziz, Dinia/I-2952-2016 | 7410138212; 14830491400; 55721975100; 7005615041; 57210160902; 9334962600 | chpark@ynu.ac.kr; | MATERIALS CHEMISTRY AND PHYSICS | MATER CHEM PHYS | 0254-0584 | 1879-3312 | 265 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 4.778 | 36.1 | 0.5 | 2025-07-30 | 7 | 7 | Down-conversion; Solar cell; ZnO | LUMINESCENT LAYERS; UP-CONVERSION; EFFICIENCY; PERFORMANCE | Down-conversion; Solar cell; Yb:ZnO; Yb<sub>2</sub>O<sub>3</sub>; ZnO | Energy transfer; Glass; Metallic films; Silicon; Silicon solar cells; Ytterbium compounds; Zinc oxide; Zinc sulfide; Conversion layers; Downconversion; Energy; Polycrystalline silicon solar cell; Property; Si solar cells; Spin coating techniques; Yb-added ZnO; ZnO; ZnO films; II-VI semiconductors | English | 2021 | 2021-06-01 | 10.1016/j.matchemphys.2021.124513 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synergic effect of ZnO nanostructures and cobalt phosphate co-catalyst on photoelectrochemical properties of GaN | Novel PEC cell design based on GaN/ZnO/CoPi heterojunction cascade was synthesized using united metal organic chemical vapor deposition (MOCVD), hydrothermal, and photo-electrodeposition strategy. Two different type of ZnO architectures viz., honeycomb (HON) and nanorods (NRs) were grown on the GaN layer by executing structure directing agents of multiwall carbon nanotubes, and ZnO buffer layer, enhancing photoelectrocatalytic (PEC) activity toward oxygen evolution reaction (OER). In an expansion of such approach, the PEC activity was further improved by incorporating photo-electrodeposited cobalt phosphate (CoPi) in synthesis system accompanying negative shift of the photocurrent onset potential. A steady-state and highest photocurrent density (J(ph)), of 4.81 +/- 0.02 mA/cm(2) was obtained with GaN/ZnO NRs/CoPi heterojunction cascade electrode at 1.23 V verses reversible hydrogen electrode (V-RHE) under simulated sunlight illumination. PL result shows quenching of photoluminescence with CoPi modification acts as co-catalyst and preferably captures hole from ZnO NRs which likely to facilitate the electron-hole (e(-)/h(+)) pair separation and OER reaction kinetics. However, CoPi modified GaN/ZnO HON and pristine GaN photoelectrodes exhibited relatively lesser photocurrent densities. Experimental evidences by electrochemical impedance (EIS) and incident photon to current conversion efficiency (IPCE) confirmed superior electrical conductivity, light absorption capability and charge transfer across GaN/ZnO NRs/CoPi heterojunction interfaces attributable to type II band alignment together with dominant synergistic effect of ZnO NRs nanostructures and CoPi oxidation co-catalyst which could augment PEC water splitting. This work encourages futuristic insights into integrated synthesis methods toward development of high performance photoelectrodes based on underexplored GaN and other heterostructures. | Patil, Santosh S.; Johar, Muhammad Ali; Hassan, Mostafa Afifi; Waseem, Aadil; Bagal, Indrajit, V; Shinde, Diksha E.; Ryu, Sang-Wan | Chonnam Natl Univ, Dept Phys, Gwangju 61186, South Korea; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, 2559 Gyeongsang Daero, Sangju, Gyeongbuk, South Korea; Modern Coll Arts Sci & Commerce Autonomous Shivaj, Pune 411005, Maharashtra, India | Shinde, Diksha/JAX-9539-2023; Waseem, Aadil/P-4804-2019; Johar, Muhammad/ABE-1852-2020; Hassan, M/GYE-0261-2022 | 57212424760; 57195470144; 57195409104; 57202382470; 57202536301; 57220928153; 7402110991 | sangwan@chonnam.ac.kr; | MATERIALS CHEMISTRY AND PHYSICS | MATER CHEM PHYS | 0254-0584 | 1879-3312 | 260 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 4.778 | 36.1 | 0.64 | 2025-07-30 | 10 | 10 | Gallium nitride; Co-catalyst; CoPi; Zinc oxide; Heterojunction; Water splitting | SINGLE-STEP FABRICATION; TIO2 NANOWIRE ARRAYS; HYDROGEN GENERATION; FACILE SYNTHESIS; WATER OXIDATION; SOLID-SOLUTION; HETEROSTRUCTURE PHOTOANODE; PERFORMANCE; NANOSHEETS; PHOTOCATALYST | Co-catalyst; CoPi; Gallium nitride; Heterojunction; Water splitting; Zinc oxide | Buffer layers; Charge transfer; Cobalt compounds; Cobalt deposits; Electrodeposition; Electrodes; Heterojunctions; II-VI semiconductors; III-V semiconductors; Image enhancement; Light absorption; Metallorganic chemical vapor deposition; Multiwalled carbon nanotubes (MWCN); Nanocatalysts; Nanorods; Organic chemicals; Organometallics; Oxide minerals; Oxygen evolution reaction; Photocurrents; Photoelectrochemical cells; Reaction kinetics; Semiconductor quantum wells; Water absorption; Zinc oxide; A3. metal organic chemical vapor deposition (MOCVD); Heterojunction interfaces; Incident photon-to-current conversion efficiencies; Oxygen evolution reaction (oer); Photoelectrocatalytic activities; Photoelectrochemical properties; Reversible hydrogen electrodes; Structure directing agents; Gallium nitride | English | 2021 | 2021-02-15 | 10.1016/j.matchemphys.2020.124141 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Thermal, structural and optical behaviour of Eu³⁺ ions in Zinc Alumino Boro-Silicate glasses for bright red emissions | In present work we report the thermal, structural and optical behaviour of 20SiO2-(20-x) B2O3-10Al2O3-10ZnO-30NaF-10ZnF2-xEu2O3 glass system where Eu2O3 ions is doped in different molar concentrations (x = 0.1, 0.5, 1.0, 1.5, 2.0 and 2.5 mol %). The Differential thermal analysis measurement was employed to study the thermal stability of the glasses through various thermal parameters such as Dietzel factor (Delta T), Hruby's parameter (KH), Weinberg Parameter (KW) and Lu and Liu Parameter (KLL). FTIR studies exhibit the presence of BO3, BO4, SiO2 vibrational units and the deconvoluted peak areas is used for the calculation of bridging and non-bridging oxygens. From the absorption spectra, the indirect bandgap energy (Eg) and Urbach's energy (EU) of the glasses have been calculated. Judd-Ofelt (JO) intensity parameters (Omega 2 and Omega 6) have been evaluated from the emission spectrum. The radiative parameters such as radiative transition probability (AR), branching ratio (beta R), stimulated emission cross-section (Sigma se) and radiative lifetimes (Tau R) were obtained using the JO parameters for the transitions 5D0 -> 7F1,2,4 of Eu3+ ions. The decay life time of the 5D0 level is found to be single-exponential for all the Eu3+ doped glasses. An increase in lifetime values for the prepared glasses was found with increase in Eu3+ concentration from 0.1 mol% to 2.0 mol%. The colour chromaticity values and CCT values show the bright red emission from the prepared glasses. | Monisha, M.; Murari, M. S.; Sayyed, M., I; Al-Ghamdi, Hanan; Almuqrin, Aljawhara H.; Lakshminarayana, G.; Kamath, Sudha D. | Manipal Acad Higher Educ, Manipal Inst Technol, Dept Phys, Glass Proc Lab, Manipal 576104, Karnataka, India; Mangalore Univ, DST Purse Program, Mangalagangothri 574199, Karnataka, India; Imam Abdulrahman Bin Faisal Univ IAU, Inst Res & Med Consultat IRMC, Dept Nucl Med Res, POB 1982, Dammam 31441, Saudi Arabia; Isra Univ, Fac Sci, Dept Phys, Amman, Jordan; Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Phys, Riyadh, Saudi Arabia; Kyungpook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu 41566, South Korea | M, Monisha/JCE-4924-2023; Sayyed, M.I/AAB-7789-2022 | 57215090803; 55792563200; 57189890554; 56524460700; 57115469100; 57194637883; 16245280000 | sudhakamath6@gmail.com; | MATERIALS CHEMISTRY AND PHYSICS | MATER CHEM PHYS | 0254-0584 | 1879-3312 | 270 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 4.778 | 36.1 | 2.13 | 2025-07-30 | 37 | 39 | Zinc alumino boro-silicate glasses; Differential thermal analysis; Photoluminescence; CIE coordinates; CCT | BISMUTH BORATE GLASSES; LUMINESCENCE PROPERTIES | CCT; CIE coordinates; Differential thermal analysis; Photoluminescence; Zinc alumino boro-silicate glasses | Differential thermal analysis; Emission spectroscopy; Europium compounds; Fourier transform infrared spectroscopy; Ions; Judd-Ofelt theory; Photoluminescence; Silica; Silicates; Thermodynamic stability; Zinc compounds; CCT; CIE coordinates; Differential thermal analyses (DTA); Optical behaviour; Red emissions; Silicate glass; Structural behaviors; Thermal behaviours; Thermal-optical; Zinc alumino boro-silicate glass; Glass | English | 2021 | 2021-09-15 | 10.1016/j.matchemphys.2021.124787 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A sensitive analytical method for the determination of SG-SP1 in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study | SG-SP1, a newly synthesised gallic acid derivative, blocks histamine release by reducing calcium influx in mast cells and inhibits inflammatory cytokine expression. This derivative has promising anti-allergic potential. Our research was designed to establish a quantitative determination method for SG-SP1 in rat plasma using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS), to validate the analytical method including stability and to characterise its pharmacokinetic behaviour in rats. After simple protein precipitation with acetonitrile including an internal standard, SG-SP1 was eluted on a reversed-phase column using a mobile phase of water and acetonitrile (2:8 v/v, including 0.1 % formic acid). The protonated precursor ion [M+H](+) and major fragment ion were confirmed at m/z 588.2 and 180.1, respectively. The substance was stable under bench and storage conditions. The analytical method met the criteria of FDA-validated bioanalytical methods and was successfully applied to a pharmacokinetic study for the first time. SG-SP1 decayed in a biphasic pattern with terminal half-life of 5.1 h and clearance of about 3.2 L/h/kg. Double peaks were observed following oral administration, and the absolute oral bioavailability was similar to 1 %. (C) 2021 Elsevier B.V. All rights reserved. | Kang, Juhyung; Won, Jihyun; Fei, Xiang; Noh, Keumhan; Kim, Sang-Hyun; Seo, Seung-Young; Kang, Wonku | Sungkyunkwan Univ, Sch Pharm, Gyeonggi Do 16419, South Korea; Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea; Gachon Univ, Coll Pharm, Incheon 21936, South Korea; Univ Toronto, Leslie Dan Fac Pharm, Dept Pharmaceut Sci, 144 Coll St, Toronto, ON, Canada; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, CMRI, Daegu, South Korea | ; Fei, Xiang/D-6670-2014; Fei, Xiang/Z-1378-2019 | 57223905716; 57223909197; 56091158600; 35485094000; 57210450420; 7202469894; 7202401591 | syseo@gachon.ac.kr;wkang@cau.ac.kr; | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | J PHARMACEUT BIOMED | 0731-7085 | 1873-264X | 202 | SCIE | CHEMISTRY, ANALYTICAL;PHARMACOLOGY & PHARMACY | 2021 | 3.571 | 36.2 | 0.35 | 2025-07-30 | 4 | 4 | SG-SP1; HPLC-MS/MS; Rats; Pharmacokinetics | MAST-CELLS | HPLC-MS/MS; Pharmacokinetics; Rats; SG-SP1 | Administration, Oral; Animals; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Plasma; Rats; Reproducibility of Results; Tandem Mass Spectrometry; acetonitrile; cgk 012; corn oil; formic acid; gallic acid derivative; sg sp1; unclassified drug; water; drug; analytic method; animal experiment; animal tissue; antiallergic activity; Article; blood sampling; chemical analysis; controlled study; drug bioavailability; drug blood level; drug clearance; drug design; drug determination; drug half life; drug stability; drug storage; drug structure; elimination rate constant; Food and Drug Administration; liquid chromatography-mass spectrometry; nonhuman; nuclear magnetic resonance spectroscopy; pharmacokinetic parameters; phase separation; precipitation; priority journal; quality control; quantitative analysis; rat; animal; high performance liquid chromatography; oral drug administration; plasma; reproducibility; tandem mass spectrometry | English | 2021 | 2021-08-05 | 10.1016/j.jpba.2021.114151 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Deciphering the role of a membrane-targeting domain in assisting endosomal and autophagic membrane localization of a RavZ protein catalytic domain | The bacterial effector protein RavZ from a pathogen can impair autophagy in the host by delipidating the mammalian autophagy-related gene 8 (mATG8)-phosphatidylethanolamine (PE) on autophagic membranes. In RavZ, the membrane-targeting (MT) domain is an essential function. However, the molecular mechanism of this domain in regulating the intracellular localization of RavZ in cells is unclear. In this study, we found that the fusion of the green fluorescent protein (GFP) to the MT domain of RavZ (GFP-MT) resulted in localization primarily to the cytosol and nucleus, whereas the GFP-fused duplicated-MT domain (GFP-2xMT) localized to Rab5- or Rab7-positive endosomes. Similarly, GFP fusion to the catalytic domain (CA) of RavZ (GFP-CA) resulted in localization primarily to the cytosol and nucleus, even in autophagy-induced cells. However, by adding the MT domain to GFP-CA (GFP-CA-MT), the cooperation of MT and CA led to localization on the Rab5-positive endosomal membranes in a wortmannin-sensitive manner under nutrient-rich conditions, and to autophagic membranes in autophagy-induced cells. In autophagic membranes, GFP-CA-MT delipidated overexpressed or endogenous mATG8-PE. Furthermore, GFP-CA(Delta alpha 3)-MT, an alpha 3 helix deletion within the CA domain, failed to localize to the endosomal or autophagic membranes and could not delipidate overexpressed mATG8-PE. Thus, the CA or MT domain alone is insufficient for stable membrane localization in cells, but the cooperation of MT and CA leads to localization to the endosomal and autophagic membranes. In autophagic membranes, the CA domain can delipidate mATG8-PE without requiring substrate recognition mediated by LC3-interacting region (LIR) motifs. | Park, Jui-Hee; Lee, Seung-Hwan; Park, Sang-Won; Jun, Yong-Woo; Kim, Kunhyung; Jeon, Pureum; Kim, Myungjin; Lee, Jin-A; Jang, Deok-Jin | Kyungpook Natl Univ, Coll Ecol & Environm, Dept Ecol Sci, Sangju 37224, South Korea; Korea Brain Res Inst, Lab Neurobiochem, Emot Cognit & Behav Res Grp, Daegu 41062, South Korea; Hannam Univ, Coll Life Sci & Nano Technol, Dept Biol Sci & Biotechnol, Daejeon 34054, South Korea | 57222271460; 57211746078; 57211486702; 56363004900; 57202965696; 57208213892; 59805564900; 35337365000; 22234503100 | leeja@hnu.kr;jangdj@knu.ac.kr; | BMB REPORTS | BMB REP | 1976-6696 | 1976-670X | 54 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2021 | 5.041 | 36.2 | 0.07 | 2025-07-30 | 2 | 1 | Autophagy; Delipidation; mATG8; Membrane-targeting domain; RavZ | COMPLEX; HOST; LIR | Autophagy; Delipidation; mATG8; Membrane-targeting domain; RavZ | Autophagy; Autophagy-Related Proteins; Catalytic Domain; Endosomes; Green Fluorescent Proteins; Humans; Intracellular Membranes; autophagy related protein; green fluorescent protein; autophagy; endosome; enzyme active site; human; intracellular membrane; metabolism | English | 2021 | 2021-02-28 | 10.5483/bmbrep.2021.54.2.190 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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