연구성과로 돌아가기
2020 연구성과 (136 / 270)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | The Effects of Distribution of Image Matched Fiducial Markers on Accuracy of Computer-Guided Implant Surgery | Purpose Image registration of the optical intraoral scan to computed tomography image is essential for computer-guided implant surgery. The remaining teeth, which are considered to be congruent structures observed in the scan and radiographic images, are used to perform the image registration. The purpose of this study was to evaluate the effects of the distribution of matching fiducial points on the accuracy of the image registration. Materials and Methods A partially edentulous model with three anterior remaining teeth was prepared. Two mini dental implants were inserted in the posterior edentulous areas on both sides, and computed tomography and surface scan data were obtained. Three groups were set according to the distribution of the image matching points used: localized distribution, unilateral distribution, and bilateral distribution. Fifteen graduate students performed the registration process in each group using the same image matching method. The accuracy of image registration was evaluated by measuring the geometric discrepancies between the radiographic and registered scan images in the anterior, middle, and posterior regions. One-way and two-way analysis of variance with the Tukey HSD post hoc test were used for statistical analysis (alpha = 0.05) Results In general, the registration discrepancy was lowest in the bilateral distribution group, followed by the unilateral distribution and localized distribution groups (p< 0.001). In the regional analysis, the registration error tended to increase as the measurement region moved farther from the matching points. The distribution of the matching points and measurement regions had a statistical interaction in the accuracy of image registration. Conclusion The accuracy of image registration of the surface scan to the computed tomography is affected by the matching point distribution that can be improved by placing artificial markers in the edentulous areas. | Choi, Yong-Do; Mai, Hang-Nga; Mai, Hai Yen; Ha, Jung-Hong; Li, Lin-Jie; Lee, Du-Hyeong | Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea; Kyungpook Natl Univ, Inst Translat Res Dent, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Conservat Dent, Daegu, South Korea; Kowa Dent Clin, Shanghai, Peoples R China | Mai, Hang-Nga/Q-9865-2018 | 57217787575; 56964780900; 57217872800; 55549831900; 56340804200; 35770948000 | deweylee@knu.ac.kr; | JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY | J PROSTHODONT | 1059-941X | 1532-849X | 29 | 5 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 2.752 | 38.6 | 0.78 | 2025-06-25 | 10 | 12 | Computer-guided implant surgery; image registration; computed tomography; optical scan; accuracy; fiducial marker; distribution | PLANNING SOFTWARE; SURGICAL GUIDES; DRILLING GUIDE; PLACEMENT; REGISTRATION; FABRICATION | accuracy; computed tomography; Computer-guided implant surgery; distribution; fiducial marker; image registration; optical scan | Dental Implants; Fiducial Markers; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Mouth, Edentulous; Surgery, Computer-Assisted; Tomography, X-Ray Computed; computer assisted surgery; fiducial marker; human; image processing; mouth disease; three-dimensional imaging; tooth implant; x-ray computed tomography | English | 2020 | 2020-06 | 10.1111/jopr.13171 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | The Impact of National Surveillance for Liver Cancer: Results from Real-World Setting in Korea | Background/Aims: The National Liver Cancer Surveillance Program (NLCSP) was established in 2003 to reduce the socioeconomic burden imposed by liver cancer (LC). We aimed to investigate the effectiveness of the NLCSP in South Korea with respect to survival benefits and cost, after adjusting for various confounding factors. Methods: We used the National Health Insurance Service claims data linked with the NLCSP from 2004 to 2015. The Cox proportional hazard model and generalized linear model were used to determine the effects of the NLCSP on the early detection of LC, survival, and medical costs. Results: From 2006 to 2010, 66,632 patients (surveillance group: 10,527 and no surveillance group: 56,105) newly diagnosed with LC were included in the study. The odds of the early detection of LC was 1.82 (95% confidence interval [Cl], 1.73 to 1.93) times higher among patients who participated in the NLCSP once within the 2-year period prior to the diagnosis of LC than among those who did not participate in the surveillance program. The mortality rate of patients who participated in the NLCSP was 22.0% lower (hazard ratio, 0.78; 95% CI, 0.76 to 0.80) than that of those who did not participate. When compared with the group who did not participate in surveillance, the group who participated in the NLCSP had higher total medical costs; however, their cost per day was lower after adjustment during the follow-up period. Conclusions: This study highlights the survival benefit in patients who participated in the NLCSP and the need for continuous improvements of the NLCSP in South Korea. | Kwon, Jin Won; Tchoe, Ha Jin; Lee, Jayoun; Suh, Jae Kyung; Lee, Jeong-Hoon; Shin, Sangjin | Natl Evidence Based Healthcare Collaborating Agcy, Div Healthcare Technol Assessment Res, Seoul, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Seoul Natl Univ, Dept Internal Med & Liver Res, Coll Med, Seoul, South Korea | Tchoe, Hajin/GSE-2969-2022; Lee, Jeong-Hoon/Q-1055-2018 | 16202951700; 57190186684; 57145528100; 57204712156; 55936232200; 57201964364 | jshin@neca.re.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 14 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 4.519 | 38.6 | 1.02 | 2025-06-25 | 19 | 20 | Liver neoplasms; Early detection of cancer; Republic of Korea | HEPATOCELLULAR-CARCINOMA SURVEILLANCE; CLINICAL-PRACTICE GUIDELINES; C VIRUS-INFECTION; UNITED-STATES; SURVIVAL; MANAGEMENT; MORTALITY; IMPROVES | Early detection of cancer; Liver neoplasms; Republic of Korea | Adult; Aged; Cost of Illness; Early Detection of Cancer; Female; Humans; Linear Models; Liver Neoplasms; Male; Mass Screening; Middle Aged; Population Surveillance; Program Evaluation; Proportional Hazards Models; Republic of Korea; Survival Rate; adult; aged; Article; cancer epidemiology; cancer mortality; cancer risk; cancer survival; controlled study; cost benefit analysis; cost of illness; early cancer diagnosis; female; follow up; health care cost; human; liver cancer; major clinical study; male; middle aged; South Korea; very elderly; young adult; epidemiology; health survey; liver tumor; mass screening; mortality; procedures; program evaluation; proportional hazards model; statistical model; survival rate | English | 2020 | 2020-01 | 10.5009/gnl18522 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Treatment Outcomes and Prognostic Factors of Acute variceal Bleeding in Patients with Hepatocellular Carcinoma | Background/Aims: The treatment outcomes and prognostic markers of acute variceal bleeding (AVB) in hepatocellular carcinoma (HCC) patients remain unclear. Therefore, we evaluated the clinical outcomes and prognostic factors of AVB in HCC patients. Methods: Cirrhotic patients with endoscopically confirmed AVB between 2007 and 2013 were enrolled in this prospective study. Prognostic factors were identified by multivariate Cox proportional hazards regression analysis. Results: Among the 329 enrolled patients, 125 patients (38.0%) were diagnosed with HCC. The 6-week mortality rates of all enrolled AVB patients and the HCC subgroup were 14.9% and 26.4%. The 5-day treatment failure, 6-week mortality, cirrhosis-related complications, and duration of hospitalization were greater in HCC patients than in non-HCC patients (all p= 15.5 and BCLC stage C-D died within 6 weeks, and the 6-week mortality risk was 21-fold higher in this group than in the group with a lower MELD score and earlier HCC stage (p<0.001). Conclusions: The 5-day treatment failure and 6-week mortality rates were significantly higher among AVB patients with HCC than those without HCC. The MELD score and the presence and stage of HCC are strong predictors of 6-week mortality in patients with AVB. | Lee, Yu Rim; Park, Soo Young; Tak, Won Young | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea | 57194094753; 57191674344; 7004074582 | psyoung0419@gmail.com;wytak@knu.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 14 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 4.519 | 38.6 | 1.02 | 2025-06-25 | 21 | 24 | Hemorrhage; Esophageal and gastric varices; End stage liver disease; Carcinoma; hepatocellular; Mortality | LIVER-DISEASE MELD; PORTAL-HYPERTENSION; CONSENSUS WORKSHOP; MORTALITY; RISK; MANAGEMENT; HEMORRHAGE; DIAGNOSIS; CIRRHOSIS; THERAPY | Carcinoma, hepatocellular; End stage liver disease; Esophageal and gastric varices; Hemorrhage; Mortality | Aged; Carcinoma, Hepatocellular; End Stage Liver Disease; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Prognosis; Prospective Studies; Retrospective Studies; Severity of Illness Index; Treatment Outcome; beta adrenergic receptor blocking agent; cephalosporin; ciprofloxacin; enbucrilate; somatostatin; terlipressin; acute variceal bleeding; adult; aged; antibiotic therapy; Article; bleeding; cancer staging; Child Pugh score; contrast enhancement; controlled study; endoscopy; esophagus varices bleeding; female; follow up; human; human cell; length of stay; liver cell carcinoma; major clinical study; male; Model For End Stage Liver Disease Score; mortality rate; prognostic assessment; proportional hazards model; prospective study; stomach varices bleeding; treatment failure; treatment outcome; university hospital; x-ray computed tomography; end stage liver disease; esophagus varices; gastrointestinal hemorrhage; liver cirrhosis; liver tumor; middle aged; prognosis; retrospective study; severity of illness index; treatment outcome | English | 2020 | 2020-07 | 10.5009/gnl19155 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Letter | Large Venous Sac Thrombus Formation after Endovascular Embolization of Ruptured Pulmonary Arteriovenous Malformation: Usefulness of Time-Resolved MR Angiography in Decision Making | Hong, Jihoon; Lee, Sang Yub; Cha, Jung Guen; Lim, Jae-Kwang; Cha, Seung-Ick; Do, Young Woo | Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Radiol, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Thorac & Cardiovasc Surg, 130 Dongdeok Ro, Daegu 41944, South Korea | ; Lee, Joo/C-3851-2013 | 57215858314; 56016177400; 57206855971; 55515341400; 35227126400; 57189600352 | lsyrad@gmail.com; | JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY | J VASC INTERV RADIOL | 1051-0443 | 1535-7732 | 31 | 11 | SCIE | PERIPHERAL VASCULAR DISEASE;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2020 | 3.464 | 38.7 | 0 | 2025-06-25 | 0 | 0 | Arteriovenous Malformations; Clinical Decision-Making; Embolization, Therapeutic; Humans; Magnetic Resonance Angiography; Male; Middle Aged; Predictive Value of Tests; Pulmonary Artery; Pulmonary Veins; Rupture, Spontaneous; Thrombosis; Treatment Outcome; adult; arterial embolization; artery diameter; case report; clinical article; computer assisted tomography; digital subtraction angiography; dyspnea; follow up; hematothorax; human; Letter; magnetic resonance angiography; male; middle aged; patient decision making; priority journal; pulmonary arteriovenous fistula; thorax pain; thrombus; adverse event; arteriovenous malformation; artificial embolization; clinical decision making; diagnostic imaging; predictive value; pulmonary artery; pulmonary vein; rupture; thrombosis; treatment outcome | English | 2020 | 2020-11 | 10.1016/j.jvir.2020.02.019 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Decursin negatively regulates LPS-induced upregulation of the TLR4 and JNK signaling stimulated by the expression of PRP4 in vitro | The current investigation was carried out to analyze the correlation of bacterial lipopolysaccharide (LPS) and pre-mRNA processing factor 4B (PRP4) in inducing inflammatory response and cell actin cytoskeleton rearrangement in macrophages (Raw 264.7) and colorectal (HCT116) as well as skin cancer (B16-F10) cells. Cell lines were stimulated with LPS, and the expression of PRP4 as well as pro-inflammatory cytokines and proteins like IL-6, IL-1 beta, TLR4, and NF-kappa B were assayed. The results demonstrated that LPS markedly increased the expression of PRP4, IL-6, IL-1 beta, TLR4, and NF-kappa B in the cells. LPS and PRP4 concomitantly altered the morphology of cells from an aggregated, flattened shape to a round shape. Decursin, a pyranocoumarin from Angelica gigas, inhibited the LPS and PRP4-induced inflammatory response, and reversed the induction of morphological changes. Finally, we established a possible link of LPS with TLR4 and JNK signaling, through which it activated PRP4. Our study provides molecular insights for LPS and PRP4-related pathogenesis and a basis for developing new strategies against metastasis in colorectal cancer and skin melanoma. Our study emphasizes that decursin may be an effective treatment strategy for various cancers in which LPS and PRP4 perform a critical role in inducing inflammatory response and morphological changes leading to cell survival and protection against anti-cancer drugs. | Ahmed, Muhammad Bilal; Ul Islam, Salman; Lee, Young Sup | Kyungpook Natl Univ, Sch Life Sci, Coll Nat Sci, Daegu 41566, South Korea | 58689879600; 56985186700; 36013628200 | yselee@knu.ac.kr; | ANIMAL CELLS AND SYSTEMS | ANIM CELLS SYST | 1976-8354 | 2151-2485 | 24 | 1 | SCIE | CELL BIOLOGY;ZOOLOGY | 2020 | 1.815 | 38.8 | 0.89 | 2025-06-25 | 12 | 11 | LPS; PRP4; inflammation; decursin; TLR4; JNK | PROMOTES IMMUNE ESCAPE; COLON-CANCER CELLS; KAPPA-B; IMMUNOSUPPRESSIVE CYTOKINES; ANGELICA-GIGAS; LIPOPOLYSACCHARIDE; APOPTOSIS; PROTEIN; ACTIVATION; DYNAMICS | decursin; inflammation; JNK; LPS; PRP4; TLR4 | English | 2020 | 2020-01-02 | 10.1080/19768354.2020.1726811 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Trim45 is essential to the development of the diencephalon and eye in zebrafish embryos | Trim45 is one of the RING (really interesting new gene) finger containing E3 ligase, which belongs to TRIM (Tripartite motif) protein family. Its molecular biological functions have been well characterized but not in light of developmental aspects. Here, we are reporting its expression patterns and developmental functions in zebrafish embryos. First, maternal transcripts of trim45 were found at one cell stage while its zygotic messages appeared at 30% epiboly. trim45 transcripts were restricted to the optical tectum, hypothalamus, hindbrain, and pharyngeal endoderm at 24 hpf (hour post-fertilization), and further to the retinal ganglion cell layer and cranial ganglion at 36 hpf. Second, ectopic expression of trim45 by injecting its mRNAs into embryos at one cell stage caused significant expansion of the diencephalon and eye fields at 24 hpf. In contrast, knock-down of trim45 with anti-sense trim45 morpholinos reduced the size of the two tissues at 24 hpf. Finally, the spatial distribution of the transcripts from olig2 and rx1/rx3, markers for the midbrain and eye respectively, were significantly decreased in the thalamus and eye fields respectively at 24 hpf. Based upon these observations, we proposed possible roles of Trim45 in the development of the diencephalon and eye in zebrafish embryos. | Choe, Seoyeon; Huh, Tae-Lin; Rhee, Myungchull | Chungnam Natl Univ, Coll Biosci & Biotechnol, Dept Biol Sci, Brain Korea Plus 21, Daejeon 305764, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Daegu, South Korea | 57216543051; 7007119367; 7102347645 | mrhee@cnu.ac.kr; | ANIMAL CELLS AND SYSTEMS | ANIM CELLS SYST | 1976-8354 | 2151-2485 | 24 | 2 | SCIE | CELL BIOLOGY;ZOOLOGY | 2020 | 1.815 | 38.8 | 0.79 | 2025-06-25 | 9 | 9 | E3 ligases; trim45; diencephalon; eye; zebrafish embryos | PROTEIN; GOVERNS; BRAIN | diencephalon; E3 ligases; eye; trim45; zebrafish embryos | English | 2020 | 2020-03-03 | 10.1080/19768354.2020.1751281 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Characterization of Kinase Expression Related to Increased Migration of PC-3M Cells Using Global Comparative Phosphoproteome Analysis | Background/Aim: Prostate cancer (PCa) is the second-most commonly occurring cancer among men, worldwide. Although the mechanisms associated with the progression of castration-resistant prostate cancer (CRPC) have been widely studied, the mechanism associated with more distant metastases from the bone remains unknown. This study aimed to characterize potential pathogenic kinases associated with highly metastatic PCa, that may regulate phosphorylation in extensively involved and diverse signaling pathways that are associated with the development of various cancers. Materials and Methods: A mass spectrometry (MS)-based comparative phosphoproteome strategy was utilized to identify differentially expressed kinases between the highly aggressive PCa cell-lines PC-3 and PC-3M. Results: Among 2,968 phosphorylation sites in PCa cells, 151 differently expressed phosphoproteins were identified. Seven motifs: -SP-, -SxxE-, -PxS-, -PxSP-, -SxxK-, -SPxK-, and -SxxxxxP- were f ound to be highly expressed in PC-3M cells. Based on these motifs, the kinases p21-activated kinase (PAK)2, Ste20-like kinase (SLK), mammalian Ste20-like kinase (MST)4, mitogen-activated kinase kinase (MAP2K)2, and A-Raf proto-oncogene serine/threonine kinase (ARAF) were up-regulated in PC-3M cells. Conclusion: PAK2, SLK, MST4, MAP2K2, and ARAF are kinases that are potentially associated with the progression of increased migration in PC-3M cells and may represent molecule regulators or drug targets for highly metastatic PCa therapy. | Gao, Yan; Ha, Yun-Sok; Kwon, Tae Gyun; Cho, Young-Chang; Lee, Sangkyu; Lee, Jun Nyung | Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, BK21 Plus KNU Multiom Based Creat Drug Res Team, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, 807 Hoguk Ro, Daegu 41405, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu, South Korea; Chonnam Natl Univ, Coll Pharm, Gwangju, South Korea | choi, sun ryoung/AGZ-1893-2022 | 58736921100; 35487226400; 15073765400; 55472205600; 57209046767; 16301364600 | sangkyu@knu.ac.kr;ljnlover@gmail.com; | CANCER GENOMICS & PROTEOMICS | CANCER GENOM PROTEOM | 1109-6535 | 1790-6245 | 17 | 5 | SCIE | GENETICS & HEREDITY;ONCOLOGY | 2020 | 4.069 | 38.9 | 0.47 | 2025-06-25 | 8 | 8 | Metastatic prostate cancer; proteomics; phosphorylation; kinases | STE20-LIKE KINASE; PROTEIN-PHOSPHORYLATION; ANDROGEN RECEPTOR; CANCER INCIDENCE; TGF-BETA; CYCLE; SLK; ACTIVATION; NETWORKS; PATHWAY | Kinases; Metastatic prostate cancer; Phosphorylation; Proteomics | Cell Line, Tumor; Cell Movement; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Invasiveness; Phosphoproteins; Phosphorylation; Prostate; Prostatic Neoplasms; Protein Kinases; Proteomics; Signal Transduction; Up-Regulation; a raf proto oncogene serine threonine kinase; mammalian ste20 like kinase 4; mitogen activated protein kinase 1; p21 activated kinase 2; phosphoprotein; phosphotransferase; proteome; ste20 like kinase; tumor protein; unclassified drug; phosphoprotein; protein kinase; Article; cell migration; comparative study; human; human cell; male; mass spectrometry; PC-3 [Human prostate carcinoma] cell line; PC-3M cell line; phosphoproteomics; prostate cancer; protein expression; protein motif; protein phosphorylation; signal transduction; upregulation; cell motion; disease exacerbation; gene expression regulation; genetics; metabolism; pathology; phosphorylation; procedures; prostate; prostate tumor; proteomics; tumor cell line; tumor invasion | English | 2020 | 2020 (SEP-OCT) | 10.21873/cgp.20210 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Dietary composition of birds in isolated ecosystems: a case study of Black Wood Pigeon in Republic of Korea | We studied the feeding ecology of the Black Wood Pigeon (Columba janthina), a species endemic to the East Asian Pacific Islands, and determined the species' dietary composition and food preferences on Ulleung Island, South Korea, through field observations. From March 2016 to February 2018, the diversity of food items consumed was low, with the 10 most common plant species (from a total of 33) accounting for over 80%. Food availability varied depending on plant abundance, but this influence was minimized because of factors such as delayed fruit ripening. Drupes were the most favored food items (60-68%) but were replaced by nuts and weed seeds during the spring and winter months. Dietary composition and food preferences were related to the abundance of food items based on their phenology, but a steady, high preference forAphananthe asperawas observed throughout the study period. The abundance ofPrunus takesimensisin June was correlated with changes in the Black Wood Pigeon population. This study is the first to assess the feeding ecology of Black Wood Pigeons using field observations and suggests that the availability of different food items affects population changes on the East Asian Pacific islands. | Choi, Soon Kyoo; Park, Yung Chul; Park, Sung Wan; Kim, Jae Woong; Kim, Woo Yuel | Kangwon Natl Univ, Div Forest Sci, Chunchon, South Korea; Kyungpook Natl Univ, Dept Biol, Daegu, South Korea; Earth Ecol Environm Res Inst, Daejeon, South Korea; NIE, Div Natl Ecosyst Survey Res, Seocheon 33657, South Korea | 57208335720; 55494376600; 57218679194; 57218680415; 57205973456 | yueleco@gmail.com; | ECOSYSTEM HEALTH AND SUSTAINABILITY | ECOSYST HEALTH SUST | 2096-4129 | 2332-8878 | 6 | 1 | SCIE | ECOLOGY;ENVIRONMENTAL SCIENCES | 2020 | 3.116 | 38.9 | 0.09 | 2025-06-25 | 1 | 1 | Dietary composition; feeding preference; field observations; fruit; phenology; seasonal variation | WOODPIGEON COLUMBA-PALUMBUS; HEMIPHAGA-NOVAESEELANDIAE; ISLAND; FOOD; FOREST; HABITATS; JANTHINA; SUCCESS | Dietary composition; feeding preference; field observations; fruit; phenology; seasonal variation | English | 2020 | 2020-12-16 | 10.1080/20964129.2020.1803767 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Identification of Novel Prognosis and Prediction Markers in Advanced Prostate Cancer Tissues Based on Quantitative Proteomics | Background/Aim: Prostate cancer (PCa) is the most frequent cancer found in males worldwide, and its mortality rate is increasing every year. However, there are no known molecular markers for advanced or aggressive PCa, and there is an urgent clinical need for biomarkers that can be used for prognosis and prediction of PCa. Materials and Methods: Mass spectrometry-based proteomics was used to identify new biomarkers in tissues obtained from patients with PCa who were diagnosed with T2, T3, or metastatic PCa in regional lymph nodes. Results: Among 1,904 proteins identified in the prostate tissues, 344 differentially expressed proteins were defined, of which 124 were up-regulated and 216 were down-regulated. Subsequently, based on the results of partial least squares discriminant analysis and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses, we proposed that spermidine synthase (SRM), nucleolar and coiled-body phosphoprotein 1 (NOLC1), and prostacyclin synthase (PTGIS) represent new protein biomarkers for diagnosis of advanced PCa. These proteomics results were verified by immunoblot assays in metastatic PCa cell lines and by indirect enzyme-linked immunosorbent assay in prostate specimens. Conclusion: SRM was significantly increased depending on the cancer stage, confirming the possibility of using SRM as a biomarker for prognosis and prediction of advanced PCa. | Kwon, Oh Kwang; Ha, Yun-Sok; Na, Ann-Yae; Chun, So Young; Kwon, Tae Gyun; Lee, Jun Nyung; Lee, Sangkyu | Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, BK21 Plus KNU Multiom Based Creat Drug Res Team, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Urol, 807 Hoguk Ro, Daegu 41405, South Korea; Kyungpook Natl Univ, Joint Inst Regenerat Med, Daegu, South Korea | 55579791200; 35487226400; 57201530058; 8688166900; 15073765400; 16301364600; 57209046767 | ljnlover@gmail.com;sangkyu@knu.ac.kr; | CANCER GENOMICS & PROTEOMICS | CANCER GENOM PROTEOM | 1109-6535 | 1790-6245 | 17 | 2 | SCIE | GENETICS & HEREDITY;ONCOLOGY | 2020 | 4.069 | 38.9 | 1.06 | 2025-06-25 | 18 | 20 | Prostate cancer; quantitative proteomics; SRM; diagnostics; markers | EXTRACELLULAR-MATRIX; POLYAMINE METABOLISM; DIAGNOSTIC MARKERS; EXPRESSION; PROTEIN; SYNTHASE; MICROPARTICLES; TUMORIGENESIS; PROGRESSION; HALLMARKS | Diagnostics; Markers; Prostate cancer; Quantitative proteomics; SRM | Biomarkers, Tumor; Humans; Male; Prognosis; Prostatic Neoplasms; Proteomics; molecular marker; prostacyclin synthase; spermidine synthase; tumor marker; advanced cancer; Article; cancer diagnosis; cancer mortality; cancer prognosis; cancer risk; cancer staging; cancer surgery; controlled study; down regulation; enzyme linked immunosorbent assay; gene ontology; human; human tissue; immunoblotting; lymph node metastasis; major clinical study; male; partial least squares regression; prediction; prostate cancer; prostate tissue; protein expression; proteomics; quantitative analysis; upregulation; metabolism; pathology; procedures; prognosis; prostate tumor; proteomics | English | 2020 | 2020 (MAR-APR) | 10.21873/cgp.20180 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Development of diagnostic molecular markers for marker-assisted breeding against bacterial wilt in tomato | Bacterial wilt, caused by the Ralstonia pseudosolanacearum species complex, is an important vascular disease that limits tomato production in tropical and subtropical regions. Two major quantitative trait loci (QTL) of bacterial wilt resistance on chromosome 6 (Bwr-6) and 12 (Bwr-12) were previously identified in Solanum lycopersicum 'Hawaii 7996'; however, marker-assisted breeding for bacterial wilt resistance is not well established. To dissect the QTL, six cleaved amplified polymorphic sites (CAPS) and derived CAPS (dCAPS) markers within the Bwr-6 region and one dCAPS marker near Bwr-12 were developed, and resistance levels in 117 tomato cultivars were evaluated. Two markers, RsR6-5 on chromosome 6 and RsR12-1 on chromosome 12, were selected based on the genotypic and phenotypic analysis. The combination of RsR6-5 and RsR12-1 effectively distinguishes resistant and susceptible cultivars. Furthermore, the efficiency of the two markers was validated in the F-3 generation derived from the F-2 population between E6203 (susceptible) and Hawaii 7998 (resistant). Resistant alleles at both loci led to the resistance to bacterial wilt. These markers will facilitate marker-assisted breeding of tomato resistant to bacterial wilt. | Abebe, Alebel Mekuriaw; Choi, Jinwoo; Kim, Youngjun; Oh, Chang-Sik; Yeam, Inhwa; Nou, Ill-Sup; Lee, Je Min | Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea; Kyung Hee Univ, Coll Life Sci, Dept Hort Biotechnol, Yongin 17104, Gyeonggi Do, South Korea; Andong Natl Univ, Dept Hort & Breeding, Andong 36729, Gyeongbuk, South Korea; Sunchon Natl Univ, Dept Hort, Sunchon 57922, Jeonnam, South Korea | Lee, Je/AAE-7496-2020; Oh, Chang-Sik/KCY-6325-2024; Lee, Je Min/F-9797-2014 | 57192695840; 57218773806; 57218775085; 26040950100; 9733885400; 6603068277; 8885729900 | jemin@knu.ac.kr; | BREEDING SCIENCE | BREEDING SCI | 1344-7610 | 1347-3735 | 70 | 4 | SCIE | AGRONOMY;PLANT SCIENCES | 2020 | 2.086 | 39.0 | 0.98 | 2025-06-25 | 19 | 17 | tomato; bacterial wilt; polygenic resistance; molecular marker; single nucleotide polymorphism; marker-assisted breeding | QUANTITATIVE TRAIT LOCI; RALSTONIA-SOLANACEARUM; RESISTANCE; IDENTIFICATION; PEPPER; DIVERSITY; INFECTION; INSIGHTS; STRAIN; GENES | Bacterial wilt; Marker-assisted breeding; Molecular marker; Polygenic resistance; Single nucleotide polymorphism; Tomato | English | 2020 | 2020 | 10.1270/jsbbs.20027 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | A note on almost co-Kahler manifolds | We characterize almost co-Kahler manifolds with gradient Yamabe, gradient Einstein and quasi-Yamabe solitons. It is proved that if the metric of a (kappa, mu)-almost co-Kahler manifold M2n+1 is a gradient Yamabe soliton, then M2n+1 is either K-almost co-Kahler or N(kappa)-almost co-Kahler or the metric of M2n+1 is a trivial gradient Yamabe soliton. A (kappa, mu)-almost co-Kahler manifold with gradient Einstein soliton is K-almost co-Kahler. Finally, it is shown that an almost co-Kahler manifold admitting a quasi-Yamabe soliton, whose soliton vector is pointwise collinear with the Reeb vector field of the manifold, is K-almost co-Kahler. Consequently, some results of almost co-Kahler manifolds are deduced. | De, Uday Chand; Chaubey, Sudhakar K.; Suh, Young Jin | Univ Calcutta, Dept Pure Math, 35 Ballygaunge Circular Rd, Kolkata 700019, W Bengal, India; Shinas Coll Technol, Dept Math, POB 77, Shinas 324, Oman; Shinas Coll Technol, RIRCM, POB 77, Shinas 324, Oman; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea | ; Chaubey, S./ABB-6952-2021 | 7007046738; 36117508600; 7202260479 | uc_de@yahoo.com;sudhakar.chaubey@shct.edu.om;yjsuh@knu.ac.kr; | INTERNATIONAL JOURNAL OF GEOMETRIC METHODS IN MODERN PHYSICS | INT J GEOM METHODS M | 0219-8878 | 1793-6977 | 17 | 10 | SCIE | PHYSICS, MATHEMATICAL | 2020 | 1.874 | 39.1 | 3.01 | 2025-06-25 | 49 | 46 | Almost co-Kahler manifold; K-almost co-Kahler manifold; Yamabe soliton; quasi-Yamabe soliton; gradient Yamabe soliton; gradient Einstein soliton | SYMMETRY; TOPOLOGY | Almost co-Kähler manifold; gradient Einstein soliton; gradient Yamabe soliton; K -almost co-Kähler manifold; quasi-Yamabe soliton; Yamabe soliton | English | 2020 | 2020-09 | 10.1142/s0219887820501534 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Association of response time interval with neurological outcomes after out-of-hospital cardiac arrest according to bystander CPR | Background: This study intended to find out how association between response time interval (RTI) and good neurological outcome is affected by bystander CPR. We hypothesized that bystander CPR will ensure positive effect in relationship between RTI and clinical outcome. Methods: A retrospective, observational study was made with Pan-Asian Resuscitation Outcome Study data from January 2009 to December 2016. Six cities from four Asian countries were selected. EMS-treated, non-traumatic witnessed out-of-hospital cardiac arrest (OHCA) cases were included. General demographic data, prehospital cardiac arrest details and clinical outcome were collected and analyzed according to whether bystander CPR was performed. Good neurological outcome and survival discharge were primary and secondary outcomes. Results: A total of 13,245 OHCA cases were analyzed. Median EMS response time intervals were 6 min, regardless of bystander CPR. Dividing into RTI time range by 3 min, good neurological outcome and survival discharge were only significant in 3 to 6 minutes group (adjusted odds ratio [AOR] 1.42, 1.17-1.73 95% confidence interval [CI] and AOR 1.31, 1.15-1.51 95% CI) in non-bystander CPR group but in bystander CPR group significant RTI time range was 3 to 9 min (AOR 2.02, 1.82, 1.62-2.52, 1.48-2.25 95% CI for primary, AOR 1.66, 1.43, 1.41-1.96, 1.22-1.67 95% CI for secondary). Conclusions: As response time interval increased, slower deterioration of good neurological outcome and survival discharge was shown in cardiac arrest patients with bystander CPR performed. If bystander CPR is provided, RTI time range showing significant neurological outcome and survival improvement seems to be relatively lengthened. (c) 2020 Elsevier Inc. All rights reserved. | Moon, Sungbae; Ryoo, Hyun Wook; Ahn, Jae Yun; Lee, Dong Eun; Shin, Sang Do; Park, Jeong Ho | Kyungpook Natl Univ, Dept Emergency Med, Sch Med, 680 Gukchaehosang Ro, Daegu, South Korea; Seoul Natl Univ, Sch Med, Dept Emergency Med, 103 Daehak Ro, Seoul, South Korea | ; Do Shin, Sang/D-6020-2012; Ahn, Jae Yun/N-2652-2017; Lee, Dong Eun/HTN-4501-2023 | 57191584601; 55350557500; 56937505400; 57202299238; 57049712400; 57222635486 | ryoo@knu.ac.kr; | AMERICAN JOURNAL OF EMERGENCY MEDICINE | AM J EMERG MED | 0735-6757 | 1532-8171 | 38 | 9 | SCIE | EMERGENCY MEDICINE | 2020 | 2.469 | 39.1 | 1.44 | 2025-06-25 | 16 | 16 | Bystander CPR; Cardiac arrest; Good neurological recovery; Response time interval; Survival discharge | EMERGENCY MEDICAL-SERVICES; CARDIOPULMONARY-RESUSCITATION; SURVIVAL; DEMAND; IMPACT; URBAN | Bystander CPR; Cardiac arrest; Good neurological recovery; Response time interval; Survival discharge | Aged; Aged, 80 and over; Asia; Cardiopulmonary Resuscitation; Emergency Medical Services; Female; Humans; Male; Middle Aged; Nervous System Diseases; Out-of-Hospital Cardiac Arrest; Retrospective Studies; Time-to-Treatment; adult; aged; Article; clinical outcome; controlled study; cross-sectional study; demography; emergency response time; female; hospital discharge; human; major clinical study; male; neurology; observational study; out of hospital cardiac arrest; priority journal; response time interval; resuscitation; retrospective study; survival; Asia; clinical trial; complication; emergency health service; middle aged; multicenter study; neurologic disease; out of hospital cardiac arrest; time to treatment; very elderly | English | 2020 | 2020-09 | 10.1016/j.ajem.2020.05.108 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Transtracheal ultrasonographic confirmation of endotracheal intubation using I-gel and an endotracheal tube introducer | Background: This study aimed to investigate the efficacy of transtracheal ultrasonography in confirming the placement of an endotracheal tube introducer during endotracheal intubation using the I-gel supraglottic airway as a guide. Methods: In this prospective study, endotracheal intubation using an endotracheal tube introducer through the I-gel was performed in patients with return of spontaneous circulation after I-gel insertion for out-of-hospital cardiac arrest. The introducer placement was assessed by the occurrence of hyperechoic artifacts within the trachea or esophagus in transtracheal ultrasonography. Results of ultrasonography were confirmed by waveform capnography in the case of tracheal artifacts and direct visualization by laryngoscopy in the case of esophageal artifacts. Results: One hundred and six patients were enrolled in this study. In transtracheal ultrasonography, artifacts of introducer in the trachea and esophagus were observed in 80 (75.5%) and 26 (24.5%) patients, respectively. Transtracheal ultrasonography in identifying the placement of introducers revealed a sensitivity of 100% (95% CI 95.4 to 100), specificity of 96.3% (95% CI 81.0 to 99.9), a PPV of 98.7% (95% CI 92.0 to 99.8), and a NPV of 100% (95% CI 94.8 to 99.9). Conclusion: Transtracheal ultrasonography is an accurate method for identifying introducer placement during endotracheal intubation using an endotracheal tube introducer through the I-gel. (C) 2020 Elsevier Inc. All rights reserved.Y | Park, Sin-Youl; Kim, Jong Kun | Yeungnam Univ, Dept Emergency Med, Coll Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Emergency Med, 130 Dongdeck Ro, Daegu 41404, South Korea | Kim, Joo/JAZ-0897-2023 | 56184913500; 55915816900 | kim7155@knu.ac.kr; | AMERICAN JOURNAL OF EMERGENCY MEDICINE | AM J EMERG MED | 0735-6757 | 1532-8171 | 38 | 12 | SCIE | EMERGENCY MEDICINE | 2020 | 2.469 | 39.1 | 0 | 2025-06-25 | 2 | 2 | Endotracheal intubation; Supraglottic airway device; Ultrasonography; Esophageal intubation; Airway management | RESUSCITATION COUNCIL GUIDELINES; SUPRAGLOTTIC AIRWAY DEVICE; BLIND INTUBATION; ULTRASOUND; PLACEMENT; ACCURACY | Airway management; Endotracheal intubation; Esophageal intubation; Supraglottic airway device; Ultrasonography | Aged; Artifacts; Capnography; Esophagus; Female; Humans; Intubation, Intratracheal; Laryngeal Masks; Laryngoscopy; Male; Out-of-Hospital Cardiac Arrest; Return of Spontaneous Circulation; Trachea; Ultrasonography; adult; aged; Article; artifact; capnometry; controlled study; demography; echography; endotracheal intubation; female; human; laryngoscopy; major clinical study; male; out of hospital cardiac arrest; outcome assessment; priority journal; respiration control; resuscitation; return of spontaneous circulation; sensitivity and specificity; waveform; diagnostic imaging; endotracheal intubation; esophagus; laryngeal mask; procedures; return of spontaneous circulation; trachea | English | 2020 | 2020-12 | 10.1016/j.ajem.2020.07.080 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Yamabe solitons and gradient Yamabe solitons on three-dimensional N(k)-contact manifolds | If a three-dimensional N(k)-contact metric manifold M admits a Yamabe soliton of type (M, g, V), then the manifold has a constant scalar curvature and the flow vector field V is Killing. Furthermore, either M has a constant curvature k or the flow vector field V is a strict contact infinitesimal transformation. Also, we prove that if the metric of a three-dimensional N(k)-contact metric manifold M admits a gradient Yamabe soliton, then either the manifold is flat or the scalar curvature is constant. Moreover, either the potential function is constant or the manifold is of constant sectional curvature k. Finally, we have given an example to verify our result. | Suh, Young Jin; De, Uday Chand | Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, RIRCM, Daegu 41566, South Korea; Univ Calcutta, Dept Pure Math, 35 Ballygaunge Circular Rd, Kolkata 700019, W Bengal, India | 7202260479; 7007046738 | yjsuh@knu.ac.kr;uc_de@yahoo.com; | INTERNATIONAL JOURNAL OF GEOMETRIC METHODS IN MODERN PHYSICS | INT J GEOM METHODS M | 0219-8878 | 1793-6977 | 17 | 12 | SCIE | PHYSICS, MATHEMATICAL | 2020 | 1.874 | 39.1 | 1.3 | 2025-06-25 | 20 | 22 | N(k)-contact manifold; Yamabe soliton; constant scalar curvature; strict contact infinitesimal transformation | constant scalar curvature; N (k)-contact manifold; strict contact infinitesimal transformation; Yamabe soliton | English | 2020 | 2020-10 | 10.1142/s0219887820501777 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Article | Carbon-coated ultrasmall gadolinium oxide (Gd2O3@C) nanoparticles: Application to magnetic resonance imaging and fluorescence properties | Carbon may be an ideal surface-coating material on nanoparticles (NPs) for biomedical applications because carbon is biocompatible, nearly chemically inert, and photoluminescent in the visible region. In this research, the carbon-coated ultrasmall gadolinium oxide (Gd2O3@C) core-shell NPs (core = Gd2O3; shell = carbon) were synthesized in aqueous solution using a simple method. The ultrasmall Gd2O3@C NPs (davg = 3.1 nm; aavg = 18.9 nm) had excellent colloidal stability, very high r1 value (16.26 s−1 mM−1; r2/r1 = 1.48), and exhibited photoluminescence in the visible region. In vivo positive (i.e., T1) magnetic resonance images of high contrast indicated that the ultrasmall Gd2O3@C NPs should be a potential T1 magnetic resonance imaging (MRI) contrast agent. Additionally, strong fluorescence in the visible region was observed due to carbon coating on the NP surfaces, indicating that the ultrasmall Gd2O3@C NPs are eligible for use as a dual-modal imaging agent. © 2019 Elsevier B.V. | Yue, Huan; Marasini, Shanti; Ahmad, Mohammad Yaseen; Ho, Son Long; Cha, Hyunsil; Liu, Shuwen; Jang, Yeong Ji; Tegafaw, Tirusew; Ghazanfari, Adibehalsadat; Miao, Xu; Chae, Kwon Seok; Chang, Yongmin; Lee, Gang Ho | Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Molecular Medicine and Medical & Biological Engineering, DNN, School of Medicine, KNU and Hospital, Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Biology Education, DNN, Teachers' College, KNU, Taegu, 41566, South Korea; Department of Molecular Medicine and Medical & Biological Engineering, DNN, School of Medicine, KNU and Hospital, Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea | 57200329016; 57200329199; 57203054570; 55659242700; 57189728122; 57208926248; 57208924196; 55983618600; 57200327606; 57195598056; 15743626400; 7501840633; 7404851841 | ychang@knu.ac.kr; | Colloids and Surfaces A: Physicochemical and Engineering Aspects | COLLOID SURFACE A | 0927-7757 | 1873-4359 | 586 | SCIE | CHEMISTRY, PHYSICAL | 2020 | 4.539 | 39.2 | 1.14 | 2025-06-25 | 25 | Carbon coating; Core-Shell; Fluorescence properties; Magnetic resonance imaging; Ultrasmall Gd<sub>2</sub>O<sub>3</sub>@C nanoparticle | Biocompatibility; Coatings; Fluorescence; Magnetic resonance imaging; Medical applications; Nanomagnetics; Nanoparticles; Resonance; Shells (structures); Sols; carbon nanoparticle; contrast medium; glucose; hydroxyl group; nanoparticle; ultrasmall gadolinium oxide nanoparticle; unclassified drug; Biomedical applications; Carbon coating; Colloidal Stability; Core shell; Fluorescence properties; Magnetic resonance imaging contrast agents; Nanoparticle (NPs); Ultra-small; animal experiment; aqueous solution; Article; cell mediated cytotoxicity; crystal structure; fluorescence imaging; hydrodynamics; in vitro study; in vivo study; light absorption; measurement; mouse; nonhuman; nuclear magnetic resonance imaging; photoluminescence; priority journal; synthesis; Gadolinium compounds | English | Final | 2020 | 10.1016/j.colsurfa.2019.124261 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: