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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | COVID-19 Vaccine Acceptance during Pregnancy and Influencing Factors in South Korea | Pregnant women were excluded from vaccination against Coronavirus 2019 (COVID-19) until September 2021 in South Korea. Although vaccination for pregnant women started in October 2021, vaccine acceptance in pregnant women is yet unknown. This cross-sectional study aimed to investigate COVID-19 vaccine acceptance during pregnancy and influencing factors. An anonymous survey was distributed in obstetrics departments to all pregnant or postpartum women, during the prenatal or postpartum visit. The proportion of self-reported COVID-19 vaccination during pregnancy among 436 women was 26.6%. Pregnancy-related independent factors influencing maternal COVID-19 vaccination were "received vaccine information about from obstetrics and gynecology (OBGYN) doctors" (OR 3.41, 95% CI 2.05-5.65), "cohabitant COVID-19 vaccination" (OR 2.43, 95% CI 1.06-5.59), and "second trimester" (OR 7.35, 95% CI 1.54-35.15). In women who did not want to get vaccinated, the most common reason for COVID-19 vaccination hesitancy was concern that COVID-19 vaccine might affect the fetus (91.7%, 243/266), followed by distrust in COVID-19 vaccine effectiveness (42.6%, 113/266). This study showed that providing information about maternal COVID-19 vaccination, especially by OBGYN doctors, is crucial for increasing vaccination coverage in pregnant women. Providing updated evidence of COVID-19 vaccine efficacy and safety in pregnant women may be also helpful for increasing vaccine acceptance. | Yoon, Heesu; Choi, Bo Yun; Seong, Won Joon; Cho, Geum Joon; Na, Sunghun; Jung, Young Mi; Jo, Ji Hye; Ko, Hyun Sun; Park, Joong Shin | Catholic Univ Korea, Coll Med, Dept Obstet & Gynecol, Seoul St Marys Hosp, Seoul 06591, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41404, South Korea; Korea Univ, Dept Obstet & Gynecol, Coll Med, Seoul 08308, South Korea; Kangwon Natl Univ, Kangwon Natl Univ Hosp, Sch Med, Dept Obstet & Gynecol, Chunchon 24289, South Korea; Seoul Natl Univ, Dept Obstet & Gynecol, Coll Med, Seoul 03080, South Korea; Catholic Univ Korea, Coll Med, Dept Obstet & Gynecol, Yeouido St Marys Hosp, Seoul 07345, South Korea | Park, Joong/D-5741-2012 | 57925890700; 57925890800; 26656946000; 12545334500; 55489142900; 57204270409; 57201213132; 37026301100; 57049864100 | mongkoko@catholic.ac.kr;jsparkmd@snu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 19 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 1.59 | 2025-06-25 | 12 | 10 | COVID-19; pregnancy; vaccination; acceptance | HEALTH-CARE ORGANIZATIONS; UNITED-STATES; WOMEN; PRETERM; BIRTH; AGE | acceptance; COVID-19; pregnancy; vaccination | influenza vaccine; SARS-CoV-2 vaccine; adult; Article; controlled study; coronavirus disease 2019; cross-sectional study; distrust; echography; female; fetus; geographic distribution; gynecology; human; influenza; influenza vaccination; major clinical study; passive immunization; pregnancy; pregnancy complication; pregnant woman; puerperium; second trimester pregnancy; self report; South Korea; vaccination; vaccination coverage; vaccine hesitancy | English | 2022 | 2022-10 | 10.3390/jcm11195733 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Customized Color Settings of Digitally Assisted Vitreoretinal Surgery to Enable Use of Lower Dye Concentrations During Macular Surgery | PurposeThis study evaluated the color contrast ratio (CCR) of the internal limiting membrane (ILM) using different color settings of digitally assisted vitreoretinal surgery (DAVS) with different indocyanine green (ICG) concentrations.s MethodsThis is a prospective comparative observational study. Consecutive patients that underwent 25G vitrectomy and ILM peeling using a standard operating microscope (SOM) (25 eyes), DAVS Ver. 1.1 (12 eyes), or DAVS Ver. 1.3 (13 eyes) were enrolled. The SOM and DAVS Ver. 1.1 groups used 0.075% ICG, and the DAVS Ver. 1.3 group used 0.025% ICG. In DAVS Ver. 1.1, macular CCR was compared between four different presets in the red, green, and blue channels: Default (Red (R) 100%, Green (G) 100%, and Blue (B) 100%); Preset 1 (R 20%, G 100%, B 100%); Preset 2 (R 80%, G 80%, B 100%), and Preset 3 (R 85%, G 100%, B 90%). In DAVS Ver. 1.3, macular CCR was evaluated using two different customized settings that modified the hue and saturation: Customized Setting 1 (R 86, G 100, B 100%, Hue +2 degrees, Saturation 90%, Gamma 1.2) and Customized Setting 2 (R 90, G 100, B 100%, Hue +20 degrees, Saturation 100%, Gamma 0.9). All patients underwent ophthalmologic examinations including BCVA at baseline and at 12 months. ResultsIn DAVS Ver. 1.1, macular CCR was highest in Preset 3 (P 0.05, respectively). ConclusionCustomized DAVS settings enabled surgeons to use a 3-fold lower ICG concentration in ILM peeling. | Park, Su Jin; Do, Jae Rock; Shin, Jae Pil; Park, Dong Ho | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Ophthalmol, Daegu, South Korea; Kyungpook Natl Univ, Biomed Res Inst, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea | 57194422330; 58600232100; 56517350400; 36676632900 | DongHo_Park@knu.ac.kr; | FRONTIERS IN MEDICINE | FRONT MED-LAUSANNE | 2296-858X | 8 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 1.59 | 2025-06-25 | 10 | 10 | vitrectomy; macular surgery; epiretinal membrane (ERM); ILM peeling; 25 gauge pars plana vitrectomy | INTERNAL LIMITING MEMBRANE; BRILLIANT BLUE-G; INDOCYANINE-GREEN; HOLE SURGERY; TRYPAN BLUE; TOXICITY; OUTCOMES; MICROSCOPE; VITRECTOMY; REMOVAL | 25 gauge pars plana vitrectomy; epiretinal membrane (ERM); ILM peeling; macular surgery; vitrectomy | dianogreen; indocyanine green; aged; Article; best corrected visual acuity; clinical article; color; color contrast ratio; comparative study; controlled study; epiretinal membrane; female; human; internal limiting membrane; male; observational study; pars plana vitrectomy; peroperative complication; prospective study; retina macula lutea; vitreoretinal surgery | English | 2022 | 2022-01-24 | 10.3389/fmed.2021.810070 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Deep Learning for the Automatic Segmentation of Extracranial Venous Malformations of the Head and Neck from MR Images Using 3D U-Net | Background: It is difficult to characterize extracranial venous malformations (VMs) of the head and neck region from magnetic resonance imaging (MRI) manually and one at a time. We attempted to perform the automatic segmentation of lesions from MRI of extracranial VMs using a convolutional neural network as a deep learning tool. Methods: T2-weighted MRI from 53 patients with extracranial VMs in the head and neck region was used for annotations. Preprocessing management was performed before training. Three-dimensional U-Net was used as a segmentation model. Dice similarity coefficients were evaluated along with other indicators. Results: Dice similarity coefficients in 3D U-Net were found to be 99.75% in the training set and 60.62% in the test set. The models showed overfitting, which can be resolved with a larger number of objects, i.e., MRI VM images. Conclusions: Our pilot study showed sufficient potential for the automatic segmentation of extracranial VMs through deep learning using MR images from VM patients. The overfitting phenomenon observed will be resolved with a larger number of MRI VM images. | Ryu, Jeong Yeop; Hong, Hyun Ki; Cho, Hyun Geun; Lee, Joon Seok; Yoo, Byeong Cheol; Choi, Min Hyeok; Chung, Ho Yun | Kyungpook Natl Univ, Sch Med, Dept Plast & Reconstruct Surg, Daegu 41944, South Korea; DEEPNOID Co, Seoul 08376, South Korea; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Daegu 41944, South Korea | ; LEE, JIN/Q-3108-2018; Ryu, Jeong Yeop/GLQ-9419-2022 | 56366349400; 57210147816; 57211205767; 56496041000; 58548866500; 57925591300; 7404007181 | hy-chung@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 19 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 1.12 | 2025-06-25 | 6 | 7 | vascular malformations; deep learning; surgery; plastic | SCLEROTHERAPY | deep learning; plastic; surgery; vascular malformations | adolescent; adult; aged; Article; automation; child; clinical evaluation; convolutional neural network; deep learning; female; head and neck disease; human; image analysis; image processing; image segmentation; major clinical study; male; managed care; nuclear magnetic resonance imaging; pilot study; T2 weighted imaging; three-dimensional imaging; vein malformation | English | 2022 | 2022-10 | 10.3390/jcm11195593 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Editorial Material | Editorial: Next Therapeutic Targets in Ocular Diseases | Yanai, Ryoji; Okunuki, Yoko; Park, Dong Ho; Zunaina, Embong | Yamaguchi Univ, Dept Ophthalmol, Grad Sch Med, Yamaguchi, Japan; Janssen Biopharm, South San Francisco, CA USA; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Ophthalmol, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea; Univ Sains Malaysia, Sch Med Sci, Dept Ophthalmol & Visual Sci, Kubang Kerian, Malaysia | Embong, Zunaina/C-7386-2018 | 7005523093; 12446280900; 36676632900; 23491048900 | yanai@yamaguchi-u.ac.jp; | FRONTIERS IN MEDICINE | FRONT MED-LAUSANNE | 2296-858X | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 1.87 | 2025-06-25 | 4 | 4 | diabetic macular edema; glaucoma; uveitis; pediatric cataract; inherited retinal diseases; age-related macular degeneration; digitally assisted vitreoretinal surgery; 27-gauge vitrectomy | 27-gauge vitrectomy; age-related macular degeneration; diabetic macular edema; digitally assisted vitreoretinal surgery; glaucoma; inherited retinal diseases; pediatric cataract; uveitis | acrolein; baricitinib; corticosteroid; erythropoietin; methotrexate; oxymatrine; ranibizumab; salazosulfapyridine; sulforaphane; vasculotropin; best corrected visual acuity; central retinal thickness; diabetic macular edema; diabetic retinopathy; drug efficacy; drug safety; Editorial; eye disease; gene therapy; human; immunosuppressive treatment; neovascular glaucoma; risk factor; visual impairment; vitrectomy | English | 2022 | 2022-06-23 | 10.3389/fmed.2022.953377 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Effective Control of Supraventricular Tachycardia in Neonates May Requires Combination Pharmacologic Therapy | Introduction: Supraventricular tachycardia (SVT) is one of the arrhythmias that can occur in newborns. Most SVT incidents in the neonatal period are spontaneously resolved around the first year of life, but since tachycardia can frequently occur before complete resolution, appropriate medication use is required. However, no clear guidelines or consensus on the treatment of neonatal SVT have been established yet. Methods: From January 2011 to December 2021, demographic data and antiarrhythmic medications used were retrospectively analyzed for 18 newborns diagnosed with SVT at a single center. Results: A total of four medications (propranolol, amiodarone, flecainide, and atenolol) were used as maintenance therapy to prevent tachycardia recurrence, and propranolol was the most used, followed by amiodarone. Thirty-nine percent of the patients were controlled with monotherapy, but the remainder required two or more medications. The median period from medication initiation after diagnosis to the last tachycardia event was 15.5 days, and the median total duration of medication use was 362 days. None of the patients experienced any side effects of antiarrhythmic medications. The total duration of medication use was statistically significant according to the mechanism of SVT, and the usage time of the increased automaticity group was shorter than that of the re-entry group. Conclusion: Since most neonatal SVT resolves within 1 year, it is significant to provide prophylactic medication to prevent tachycardia recurrence at least until 1 year of age, and depending on the patient, the appropriate combination of medications should be identified. | Lim, Young Tae; Kim, Yeo Hyang; Kwon, Jung Eun | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu 41944, South Korea; Kyungpook Natl Univ, Div Pediat Cardiol, Childrens Hosp, Daegu 41404, South Korea | 57197274340; 57032023800; 57194002366 | blueray14@nate.com;kimyhmd@knu.ac.kr;lovecello623@gmail.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 12 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 1.12 | 2025-06-25 | 8 | 8 | newborn; arrhythmia; tachycardia; supraventricular; anti-arrhythmia agents | CHILDREN; AMIODARONE; EFFICACY | anti-arrhythmia agents; arrhythmia; newborn; supraventricular; tachycardia | adenosine; amiodarone; atenolol; esmolol; flecainide; propranolol; Article; cardioversion; clinical article; clinical effectiveness; controlled study; disease control; drug dose increase; drug efficacy; female; heart automaticity; heart failure; human; incidental finding; irritability; maintenance therapy; male; monotherapy; newborn; paroxysmal supraventricular tachycardia; patient compliance; prophylaxis; recurrence risk; reentry tachycardia; retrospective study; shock; supraventricular tachycardia; treatment duration | English | 2022 | 2022-06 | 10.3390/jcm11123279 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Factors Affecting Selection of a Dialysis Modality in Elderly Patients With Chronic Kidney Disease: A Prospective Cohort Study in Korea | BackgroundWe investigated factors associated with the selection of a dialysis modality for elderly patients compared to younger patients. MethodsThis study included 2,514 incident dialysis patients from a Korean multicenter prospective cohort. Multivariate logistic regression analyses were performed with demographic, socioeconomic, and clinical data to analyze factors associated with the chosen dialysis modality. Differences in these factors were compared between the elderly (>= 65 years) and younger (<65 years) patients. ResultsOf the enrolled patients, 1,746 (69.5%) and 768 (30.6%) selected hemodialysis (HD) and peritoneal dialysis (PD), respectively. The percentage of PD was higher in younger patients than in elderly patients (37.1 vs. 16.9%, p < 0.001). Multivariate analysis showed that planned dialysis (p < 0.001), employment status (p < 0.001), and independent economic status (p = 0.048) were independent factors for selecting PD, whereas peripheral vascular disease (p = 0.038) and tumor (p = 0.010) were factors for selecting HD in the younger group. In the elderly group, planned dialysis (p < 0.001) and congestive heart failure (CHF; p = 0.002) were associated with choosing PD; however, tumor (p = 0.006) was associated with choosing HD. A two-way ANOVA showed that planned dialysis and CHF showed a significant interaction effect with age on modality selection. ConclusionsAs the age of patients with chronic kidney disease increased, HD was more frequently selected compared to PD. Dialysis planning and CHF interacted with age in selecting dialysis modalities in elderly patients. Elderly patients were less affected by socioeconomic status than younger patients. | Cho, Jang-Hee; Lim, Jeong-Hoon; Park, Yeongwoo; Jeon, Yena; Kim, Yon Su; Kang, Shin-Wook; Yang, Chul Woo; Kim, Nam-Ho; Jung, Hee-Yeon; Choi, Ji-Young; Park, Sun-Hee; Kim, Chan-Duck; Kim, Yong-Lim | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Clin Res Ctr End Stage Renal Dis, Daegu, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul, South Korea; Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea | Cho, Jang-hee/ABD-3534-2020; Kim, Yong-Lim/AGK-3172-2022; Jung, Hee-Yeon/AFB-8578-2022; Lim, Jeong-Hoon/ABE-6003-2020; Park, Sun-Hee/LMN-0033-2024; Kim, Hyoungnae/JXN-1329-2024; Kim, Jong-Ho/R-1602-2017 | 7403536291; 55360244300; 57202108143; 57209909350; 7410205767; 34768359700; 7407743404; 56605215700; 57196396467; 7501393222; 7501831741; 8558530700; 55633533600 | ylkim@knu.ac.kr; | FRONTIERS IN MEDICINE | FRONT MED-LAUSANNE | 2296-858X | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 0.64 | 2025-06-25 | 3 | 4 | dialysis (ESKD); hemodialysis (HD); peritoneal dialysis (PD); aged; chronic kidney disease | PERITONEAL-DIALYSIS; UNITED-STATES; SURVIVAL; CHOICE; HEMODIALYSIS; OUTCOMES; NEPHROLOGISTS; EPIDEMIOLOGY; PERSPECTIVES; PROGRAMS | aged; chronic kidney disease; dialysis (ESKD); hemodialysis (HD); peritoneal dialysis (PD) | adult; aged; aging; Article; chronic kidney failure; clinical study; cohort analysis; comparative study; congestive heart failure; controlled clinical trial; controlled study; demography; economic status; employment status; end stage renal disease; female; follow up; hemodialysis; hemodialysis patient; human; major clinical study; male; middle aged; multicenter study; multivariate analysis; multivariate logistic regression analysis; peripheral vascular disease; peritoneal dialysis; prospective study; socioeconomics | English | 2022 | 2022-09-27 | 10.3389/fmed.2022.919028 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Correction | Genetic Study in Korean Pediatric Patients with Steroid-Resistant Nephrotic Syndrome or Focal Segmental Glomerulosclerosis (vol 9, 2013, 2020) | Park, Eujin; Lee, Chung; Kim, Nayoung K. D.; Ahn, Yo Han; Park, Young Seo; Lee, Joo Hoon; Kim, Seong Heon; Cho, Min Hyun; Cho, Heeyeon; Yoo, Kee Hwan; Shin, Jae Il; Kang, Hee Gyung; Ha, Il-Soo; Park, Woong-Yang; Cheong, Hae Il | Seoul Natl Univ, Dept Pediat, Coll Med, Seoul 03080, South Korea; Hallym Univ, Kangnam Sacred Heart Hosp, Dept Pediat, Coll Med, Seoul 07441, South Korea; Samsung Med Ctr, Samsung Genome Inst, Seoul 06351, South Korea; GENINUS Inc, Seoul 05836, South Korea; Univ Ulsan, Dept Pediat, Asan Med Ctr, Coll Med,Childrens Hosp, Seoul 05505, South Korea; Pusan Natl Univ, Dept Pediat, Childrens Hosp, Yangsan 50612, South Korea; Kyungpook Natl Univ, Dept Pediat, Sch Med, Daegu 41944, South Korea; Sungkyunkwan Univ, Dept Pediat, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea; Korea Univ, Dept Pediat, Guro Hosp, Seoul 02841, South Korea; Yonsei Univ, Dept Pediat, Coll Med, Seoul 03722, South Korea; Severance Childrens Hosp, Div Pediat Nephrol, Seoul 03722, South Korea; Sungkyunkwan Univ, Dept Mol Cell Biol, Sch Med, Suwon 16419, South Korea | ; Kim, Jeong/AAO-6927-2021; Park, Eujin/AAZ-5931-2020; Lee, Chung/KRP-3824-2024; SHIN, JAE IL/J-6922-2017; Kim, Seong/AAD-8853-2020 | 56194662500; 58482922800; 56532228100; 57219957477; 56701214400; 37112404100; 57213778393; 7401727726; 15724272900; 7202592702; 57964880100; 7404071546; 7005904938; 7402229389; 34567974000 | eujinpark@hallym.or.kr;spinelyc@gmail.com;bionkdk@gmail.com;medicalpooh@hanmail.net;yspark@amc.seoul.kr;pedkid@gmail.com;pedksh@gmail.com;chomh@knu.ac.kr;heeyeon1.cho@samsung.com;guroped@korea.ac.kr;shinji@yuhs.ac;kanghg@snu.ac.kr;ilsooha@snu.ac.kr;woongyang.park@samsung.com;cheonghi@snu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 11 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 0 | 2025-06-25 | 0 | 0 | erratum | English | 2022 | 2022-06 | 10.3390/jcm11113016 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Impact of Cardiac Troponin Elevation on Mortality of Patients with Acute Heart Failure: Insights from the Korea Acute Heart Failure (KorAHF) Registry | We aimed to conduct the largest study evaluating the impact of cardiac troponin (TnI) status on mid- and long-term mortality in patients admitted for acute heart failure (AHF) as compared between patients with ischemic (IHF) vs. non-ischemic heart failure (non-IHF). Among 5625 patients from the Korea Acute Heart Failure (KorAHF) registry, 4396 eligible patients with TnI measurement were analyzed. The patients were included on admission with the diagnosis of AHF, and TnI level was measured on the day of admission. A TnI value of <0.05 ng/mL was considered normal. The patients were divided into four groups according to the etiology of heart failure and the status of TnI: non-IHF with normal TnI (n = 1009) vs. non-IHF with elevated TnI (n = 1665) vs. IHF with normal TnI (n = 258) vs. IHF with elevated TnI (n = 1464). The primary outcome was death from all causes according to the etiology (non-IHF vs. IHF) and TnI elevation during the entire follow-up period of 784 days (IQR 446-1116). Elevation of TnI was observed in 71.2% of all patients with AHF. Patients with IHF had higher all-cause mortality compared to those with non-IHF. Elevated TnI was associated with higher 90-day and post-90-day mortality in the non-IHF group. IHF as compared to non-IHF and elevation of TnI were independent predictors of mortality also in the adjustment analysis. In the IHF group, however, elevated TnI had a higher mortality with only 90-day follow-up (18.6% vs. 25.9%, log-rank p < 0.001), not in the post-90-day follow-up (31.1% vs. 32.5%, log-rank p = 0.799). In conclusion, elevated TnI in patients with heart failure is associated with increased all-cause mortality regardless of the etiology of HF. Elevation of TnI was associated to a higher post-90 day mortality in patients with non-IHF but not in patients with IHF. | Lee, Nuri; Cho, Jae Yeong; Kim, Kye Hun; Kim, Hyung Yoon; Cho, Hyun-Jai; Lee, Hae-Young; Jeon, Eun-Seok; Kim, Jae-Joong; Cho, Myeong-Chan; Chae, Shung Chull; Baek, Sang Hong; Kang, Seok-Min; Choi, Dong-Ju; Yoo, Byung-Su; Oh, Byung-Hee | Chonnam Natl Univ, Dept Cardiovasc Med, Hwasun Hosp, Hwasun 58128, South Korea; Chonnam Natl Univ, Dept Cardiovasc Med, Med Sch, Gwangju 61469, South Korea; Chonnam Natl Univ Hosp, Dept Cardiovasc Med, Gwangju 61469, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul 03080, South Korea; Sungkyunkwan Univ, Dept Internal Med, Coll Med, Seoul 16419, South Korea; Univ Ulsan, Asan Med Ctr, Dept Internal Med, Coll Med, Seoul 05505, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju 28644, South Korea; Kyungpook Natl Univ, Dept Internal Med, Coll Med, Daegu 37224, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul 06591, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul 03722, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam 13620, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju 26426, South Korea | ; Jeong, Gi/AAB-2830-2021; Lee, Hye-Young/JEP-8044-2023; Kim, Kyung-Hee/JBI-8300-2023; choi, jo/O-5940-2014; Oh, Byung-Hee/G-9875-2011; Cho, Jae Yeong/GVT-2986-2022; Choi, Dong-Ju/J-5686-2012; Kim, Hyung-Kwan/ITU-6159-2023 | 55560474400; 23024350000; 56150430800; 56784568500; 35285421400; 56151235500; 7004279641; 36065764100; 7401727518; 7101962036; 7201371594; 7405685375; 35274349200; 7102851884; 57216293873 | nurilee.md@gmail.com;jaeycho@chonnam.edu;cvkimkh@gmail.com;medoc7@gmail.com;hyunjaicho@snu.ac.kr;hylee612@snu.ac.kr;eunseok.jeon@samsung.com;jjkim@amc.seoul.kr;mccho@chungbuk.ac.kr;scchae@knu.ac.kr;whitesh@catholic.ac.kr;smkang@yumc.yonsei.ac.kr;djchoi@snubh.org;yubs@yonsei.ac.kr;ohbhmed@snu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 10 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 0.16 | 2025-06-25 | 2 | 1 | acute heart failure; etiology; cardiac troponin; prognosis | HIGHLY SENSITIVE ASSAY; HOSPITALIZED-PATIENTS; MULTICENTER COHORT; DISEASE; RISK; ASSOCIATION; PREVALENCE; BIOMARKERS; RATIONALE; DESIGN | Acute heart failure; Cardiac troponin; Etiology; Prognosis | aldosterone antagonist; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; creatinine; dipeptidyl carboxypeptidase inhibitor; sodium; troponin I; acute heart failure; adult; age; aged; all cause mortality; Article; chronic kidney failure; chronic obstructive lung disease; controlled study; creatinine blood level; disease registry; female; follow up; gene expression; heart left ventricle ejection fraction; human; Korea; major clinical study; male; mortality; outcome assessment; overall survival; prognosis; sodium blood level; survival rate; systolic blood pressure | English | 2022 | 2022-05 | 10.3390/jcm11102800 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Increased Plasma Lipocalin-2 Levels in Patients with Myelin Oligodendrocyte Glycoprotein-IgG-Positive Optic Neuritis | This study aimed to evaluate the correlation between plasma lipocalin-2 (LCN2) levels and myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) seropositivity in patients with optic neuritis. Peripheral blood samples were collected from 19 patients with optic neuritis and 20 healthy controls. Plasma LCN2 and MOG-IgG levels were measured using enzyme-linked immunosorbent assay and a cell-based assay, respectively. The correlation between plasma LCN2 levels and MOG-IgG titers in patients with optic neuritis was analyzed. Receiver operating characteristic (ROC) curves were constructed to assess and compare the ability of plasma LCN2 and MOG-IgG levels for predicting optic neuritis recurrence. Patients with MOG-IgG-positive optic neuritis had significantly higher mean plasma LCN2 levels than controls and patients with MOG-IgG-negative optic neuritis (p = 0.037). Plasma LCN2 and MOG-IgG levels were significantly correlated in patients with optic neuritis (r = 0.553, p = 0.0141). There were no significant differences in the areas under the ROC curve (AUC) of plasma LCN2 (0.693, 95% confidence interval [CI] 0.443-0.880, p = 0.133) and MOG-IgG (0.641, 95% CI, 0.400-0.840, p = 0.298) levels (95% CI, -0.266-0.448, p = 0.618). Plasma LCN2 levels may aid differentiation of MOG-IgG-positive optic neuritis from MOG-IgG-negative optic neuritis. | Kim, Jong-Heon; Lee, Hyejin; Oh, Junho; Suk, Kyoungho; Chun, Bo Young | Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41944, South Korea | Oh, Junho/AAK-5189-2021 | 57203324811; 56008815900; 57216588714; 7005114595; 25644902100 | jongheonkim.phd@gmail.com;hjllls@naver.com;justdoita@nate.com;ksuk@knu.ac.kr;byjun424@hotmail.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 0.16 | 2025-06-25 | 1 | 1 | lipocalin-2; myelin oligodendrocyte glycoprotein IgG; optic neuritis; recurrence | ACTIVATION | lipocalin-2; myelin oligodendrocyte glycoprotein IgG; optic neuritis; recurrence | green fluorescent protein; immunoglobulin G; myelin oligodendrocyte glycoprotein; neutrophil gelatinase associated lipocalin; steroid; adult; antibody blood level; area under the curve; Article; best corrected visual acuity; blood level; blood sampling; cell surface; clinical article; controlled study; enzyme linked immunosorbent assay; female; follow up; gene expression; HEK293 cell line; human; human tissue; immunoglobulin blood level; informed consent; male; oligodendroglia; optic nerve; optic neuritis; real time polymerase chain reaction; receiver operating characteristic; sensitivity and specificity; steroid therapy; university hospital; visual acuity | English | 2022 | 2022-05 | 10.3390/jcm11092635 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Is Conservative Treatment Better than Surgical Treatment for Basal Ganglia Hemorrhage in a Conventionally Non-Surgical Indication Group with Poor Motor Function? | Background: The treatment options for basal ganglia intracerebral hemorrhage (ICH), either surgical or conservative, remain controversial. A previous study developed "A new modified ICH (MICH) score" that suggests which treatment option will be better for basal ganglia ICH. According to this scoring system, a MICH score of 0 or 1 indicates that conservative treatment is better than surgical treatment. The purpose of this study was to determine whether conservative treatment is still a better option for a basal ganglia hemorrhage in patients with MICH scores of 0 and 1, with initial poor motor grades. Methods: This retrospective study was comprised of 41 patients with a spontaneous basal ganglia hemorrhage. These patient groups had no previous brain lesions, their initial MICH score was 0 or 1, and the manual muscle test (MMT) of their hand was grade 2+ or lower in the initial evaluation. All patients were transferred to the Department of Rehabilitation Medicine and received rehabilitation treatment. Ten patients had an operative intervention, which was burr-hole aspiration or craniotomy with hematoma removal. The control group included 31 patients who underwent conservative treatment. Outcome evaluations used the Berg Balance Scale (BBS), Modified Barthel Index (MBI), and Brunnstrom recovery stage (BRS) which were evaluated at initial and regular follow-ups after 1, 3, and 6 months. We defined an improvement state if the BRS of their hand became 4 or more in 6 months, which means an escape from the synergic pattern. Results: Demographic characteristics showed no significant differences in age, sex, hemiplegic side, initial GCS score, presence of IVH and hydrocephalus, or distribution of MICH scores 0 and 1. There was only a significant difference in the distribution of hematoma volume between groups of less than 20 mL and groups from 21 to 50 mL (p = 0.049). There were no significant differences in MBI values in 1 month or improvement of BRS of their hand in 6 months between the two groups. Conclusions: Even in the group classified as predominantly conservative in basal ganglia hemorrhage patients, if the initial muscle strength is low, it is necessary to reconsider whether conservative treatment is superior to surgical treatment in terms of functional improvement. | Park, Chan-Hee; Lim, Min-Gyu; Jung, Hyunwoo; Jeong, Jae-Gyeong; Park, Seong-Hyun; Kim, Ae-Ryoung; Jung, Tae-Du | Kyungpook Natl Univ Hosp, Dept Rehabil Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Rehabil Med, Daegu 41944, South Korea | 57299095700; 57740068900; 57222991608; 57222016696; 21734563200; 57196257330; 36622364500 | chany9090@gmail.com;ekalsrbsla@naver.com;hwjung_87@naver.com;cloud90524@naver.com;nsdoctor@naver.com;ryoung20@hanmail.net;teeed0522@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 10 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 0 | 2025-06-25 | 0 | 0 | basal ganglia hemorrhage; stroke rehabilitation; intracerebral hemorrhage score | PRIMARY INTRACEREBRAL HEMORRHAGE; BERG BALANCE SCALE; ENDOSCOPIC SURGERY; PUTAMINAL HEMORRHAGE; PREDICTION; STROKE; EVACUATION; TRIAL; VALIDATION; HEMATOMAS | basal ganglia hemorrhage; intracerebral hemorrhage score; stroke rehabilitation | adult; aged; Article; basal ganglion hemorrhage; Berg Balance Scale; Brunnstrom recovery stage; clinical article; computer assisted tomography; conservative treatment; controlled study; craniotomy; daily life activity; demographics; female; follow up; hand function; hemiplegia; human; hydrocephalus; male; Modified Barthel Index; motor dysfunction assessment; motor performance; muscle function; muscle strength; nuclear magnetic resonance imaging; physiotherapist; retrospective study; stroke patient; stroke rehabilitation | English | 2022 | 2022-05 | 10.3390/jcm11102942 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Mycoplasma pneumoniae Pleural Effusion in Adults | Parapneumonic effusions often complicate Mycoplasma pneumoniae (MP) pneumonia, contrary to the notion that they are a rare feature of MP infection. Increased research and evidence on MP parapneumonic effusions (MPPE) can help elucidate its clinical significance as one of the variable manifestations of MP infection. This article aims to summarize the existing literature about the clinical characteristics of MPPE in adults and discuss its diagnostic implications from the perspective of pleural fluid analysis. Approximately 20-25% of adult patients with MP pneumonia develop MPPE, and its frequency in children and adults seems to be similar. Although the pathogenesis of MPPE remains to be elucidated, MP-induced cell-mediated immune mechanisms might be partially associated with the development of MPPE. MPPE usually shows mononuclear leukocyte predominance with elevated adenosine deaminase (ADA) activity, similar to tuberculous pleural effusion (TPE). The degree of increase in pleural fluid ADA levels and serum inflammatory biomarkers may help differentiate between MPPE and TPE. During the acute phase, a single positive IgM and positive polymerase chain reaction results allow for a precise and reliable MP infection diagnosis. The mainstay of treatment is the selection of adequate anti-mycoplasma antibiotics with or without corticosteroid, based on the local epidemiologic data on macrolide resistance. | Kim, Chang Ho; Lee, Jaehee | Kyungpook Natl Univ, Sch Med, Dept Internal Med, 680 Gukchaebosang Ro, Daegu 700842, South Korea | Lee, Jaehee/S-1697-2018; Lee, Jun Young/CAI-2335-2022 | 7409873555; 13805476000 | kimch@knu.ac.kr;jaelee@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 5 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 0.47 | 2025-06-25 | 3 | 6 | Mycoplasma pneumoniae; pleural effusion; diagnosis; adult | SERUM ADENOSINE-DEAMINASE; PARAPNEUMONIC EFFUSION; LABORATORY DIAGNOSIS; CLINICAL-FEATURES; MESOTHELIAL CELLS; FLUID; INFECTION; PATHOGENESIS; DISEASE; RATIO | Adult; Diagnosis; Mycoplasma pneumoniae; Pleural effusion | adenosine deaminase; antibiotic agent; macrolide; tetracycline derivative; adult respiratory distress syndrome; cellular immunity; enzyme immunoassay; human; leukocyte differential count; macrolide resistance; mononuclear cell; Mycoplasma pneumonia; Mycoplasma pneumoniae; nonhuman; nucleic acid amplification techniques; pathogenesis; pleura effusion; pleura fluid; pneumonic effusion; polymerase chain reaction; Review; serology | English | 2022 | 2022-03 | 10.3390/jcm11051281 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Non-Renal Risk Factors for Chronic Kidney Disease in Liver Recipients with Functionally Intact Kidneys at 1 Month | Chronic kidney disease (CKD) is a critical complication of liver transplants, of which non-renal risk factors are not fully understood yet. This study aimed to reveal pre- and post-transplant risk factors for CKD (= 60 mL/min/1.73 m(2), 494 (22.3%) developed CKD during a mean follow-up of 36.6 +/- 14.4 months. Age, female sex, lower body mass index, pre-transplant diabetes mellitus, and lower performance status emerged as baseline risk factors for CKD. Time-dependent Cox analyses revealed that recurrent hepatocellular carcinoma (HR = 1.93, 95% CI 1.06-3.53) and infection (HR = 1.44, 95% CI 1.12-1.60) were significant post-transplant risk factors for CKD. Patients who experienced one of those factors showed a significantly higher risk of subsequent CKD compared with the matched controls who lacked these features (p = 0.013 for recurrent hepatocellular carcinoma, and p = 0.003 for infection, respectively). This study clarifies pre- and post-transplant non-renal risk factors, which lead to renal impairment after LT independently from patients' renal functional reserve. | Kim, Deok-Gie; Hwang, Shin; Kim, Jong Man; Ryu, Je Ho; You, Young Kyoung; Choi, Donglak; Kim, Bong-Wan; Kim, Dong-Sik; Nah, Yang Won; Kim, Tae-Seok; Cho, Jai Young; Hong, Geun; Yang, Jae Do; Han, Jaryung; Suh, Suk-Won; Kim, Kwan Woo; Jung, Yun Kyung; Moon, Ju Ik; Lee, Jun Young; Kim, Sung Hwa; Lee, Jae Geun; Kim, Myoung Soo; Lee, Kwang-Woong; Joo, Dong Jin | Yonsei Univ, Coll Med, Dept Surg, Seoul 03722, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Dept Surg, Seoul 05505, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Surg, Seoul 06351, South Korea; Pusan Natl Univ, Yangsan Hosp, Sch Med, Dept Surg, Busan 49241, South Korea; Catholic Univ Korea, Coll Med, Dept Surg, Seoul 06591, South Korea; Catholic Univ Daegu, Dept Surg, Daegu 42472, South Korea; Ajou Univ, Sch Med, Dept Liver Transplantat & Hepatobiliary Surg, Suwon 16499, South Korea; Korea Univ, Coll Med, Dept Surg, Seoul 02841, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Surg, Ulsan 44033, South Korea; Keimyung Univ, Sch Med, Dongsan Med Ctr, Dept Surg, Daegu 42601, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Surg, Seongnam 13620, South Korea; EWHA Womans Univ, Coll Med, Dept Surg, Seoul 07804, South Korea; Jeonbuk Natl Univ Hosp, Dept Surg, Jeonju 54896, South Korea; Kyungpook Natl Univ Hosp, Dept Surg, Daegu 41944, South Korea; Chung Ang Univ, Coll Med, Dept Surg, Seoul 06974, South Korea; Dong A Univ Hosp, Dept Surg, Busan 49201, South Korea; Hanyang Univ, Dept Surg, Seoul 04764, South Korea; Konyang Univ Hosp, Dept Surg, Daejeon 35365, South Korea; Yonsei Univ, Wonju Coll Med, Dept Nephrol, Wonju 26426, South Korea; Yonsei Univ, Wonju Coll Med, Dept Biostat, Wonju 26426, South Korea; Seoul Natl Univ, Coll Med, Dept Surg, Seoul 03087, South Korea | ; Kim, Jong/AAH-5295-2020; Lee, Jungmin/KHT-2438-2024; Kim, Jin-Seok/AAK-5424-2020; Kim, Byung/L-6884-2019; Kim, Min-Hyuk/ITV-2946-2023; Kim, Seung-Ki/J-2742-2012; Lee, Jun Young/CAI-2335-2022; Kim, Seok-Mo/AAK-5898-2020 | 57198637675; 7404626587; 36065224600; 35178640500; 56497463600; 47961934600; 56125073000; 55742967300; 7004255651; 56319769500; 35335935300; 55558687200; 41562471000; 57214671308; 55613797400; 42761669800; 57210512996; 25824384400; 57196138117; 57226188080; 57188714240; 35268871600; 56239685700; 57216087775 | mppl01@yuhs.ac;shwang@amc.seoul.kr;yjongman21@gmail.com;ryujhhim@hanmail.net;yky602@catholic.ac.kr;dnchoi@cu.ac.kr;drbwkim@ajou.ac.kr;kimds1@korea.ac.kr;nahyw@uuh.ulsan.kr;gskim80094@naver.com;jychogs@gmail.com;ltdrhong@gmail.com;yjd@jbnu.ac.kr;jh40356@gmail.com;bumboy1@hanmail.net;d002045@naver.com;jyk1986@hotmail.com;monjuik@kyuh.ac.kr;junyoung07@yonsei.ac.kr;juniver1057@naver.com;drjg1@yuhs.ac;ysms91@yuhs.ac;kwleegs@gmail.com;djjoo@yuhs.ac; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 14 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 0 | 2025-06-25 | 0 | 0 | liver transplantation; chronic kidney disease; renal dysfunction | HEPATOCELLULAR-CARCINOMA; RENAL-DISEASE; TRANSPLANTATION; TACROLIMUS; EVEROLIMUS; MORTALITY; EFFICACY; OUTCOMES; IMPACT; SAFETY | chronic kidney disease; liver transplantation; renal dysfunction | alanine aminotransferase; antibiotic agent; aspartate aminotransferase; mycophenolate mofetil; steroid; tacrolimus; adult; age; Article; blood group ABO incompatibility; body mass; cancer patient; cancer recurrence; chronic kidney failure; cohort analysis; controlled study; cumulative incidence; deceased donor; diabetes mellitus; estimated glomerular filtration rate; female; follow up; gender; graft recipient; high risk patient; human; infection; kidney function; liver cell carcinoma; liver transplantation; major clinical study; male; middle aged; preoperative period; propensity score; retrospective study; risk factor | English | 2022 | 2022-07 | 10.3390/jcm11144203 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Prediction of radiographic progression pattern in patients with ankylosing spondylitis using group-based trajectory modeling and decision trees | ObjectiveThis study aimed to identify trajectories of radiographic progression of the spine over time and use them, along with associated clinical factors, to develop a prediction model for patients with ankylosing spondylitis (AS). MethodsData from the medical records of patients diagnosed with AS in a single center were extracted between 2001 and 2018. Modified Stoke Ankylosing Spondylitis Spinal Scores (mSASSS) were estimated from cervical and lumbar radiographs. Group-based trajectory modeling classified patients into trajectory subgroups using longitudinal mSASSS data. In multivariate analysis, significant clinical factors associated with trajectories were selected and used to develop a decision tree for prediction of radiographic progression. The most appropriate group for each patient was then predicted using decision tree analysis. ResultsWe identified three trajectory classes: class 1 had a uniformly increasing slope of mSASSS, class 2 showed sustained low mSASSS, and class 3 showed little change in the slope of mSASSS but highest mSASSS from time of diagnosis to after progression. In multivariate analysis for predictive factors, female sex, younger age at diagnosis, lack of eye involvement, presence of peripheral joint involvement, and low baseline erythrocyte sedimentation rate (log) were significantly associated with class 2. Class 3 was significantly associated with male sex, older age at diagnosis, presence of ocular involvement, and lack of peripheral joint involvement when compared with class 1. Six clinical factors from multivariate analysis were used for the decision tree for classifying patients into three trajectories of radiographic progression. ConclusionWe identified three patterns of radiographic progression over time and developed a decision tree based on clinical factors to classify patients according to their trajectories of radiographic progression. Clinically, this model holds promise for predicting prognosis in patients with AS. | Kang, Juyeon; Lee, Tae-Han; Park, Seo Young; Lee, Seunghun; Koo, Bon San; Kim, Tae-Hwan | Inje Univ, Coll Med, Dept Internal Med, Div Rheumatol,Busan Paik Hosp, Pusan, South Korea; Kyungpook Natl Univ, Dept Internal Med, Chilgok Hosp, Daegu, South Korea; Korea Natl Open Univ, Dept Stat & Data Sci, Seoul, South Korea; Hanyang Univ, Seoul Hosp, Dept Radiol, Coll Med, Seoul, South Korea; Inje Univ, Coll Med, Dept Internal Med, Div Rheumatol,Seoul Paik Hosp, Seoul, South Korea; Hanyang Univ, Dept Rheumatol, Hosp Rheumat Dis, Seoul, South Korea | Kim, Tae-Hwan/M-3962-2017; lee, sang/Q-4650-2019 | 57210833095; 57210828879; 57210022574; 57203597253; 37461487200; 57171134400 | koobonsan@gmail.com;thkim@hanyang.ac.kr; | FRONTIERS IN MEDICINE | FRONT MED-LAUSANNE | 2296-858X | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 0.32 | 2025-06-25 | 4 | 2 | ankylosing spondylitis (AS); radiographic progression; trajectory modeling; decision tree; prediction | SPINAL PROGRESSION; DISEASE-ACTIVITY; SPONDYLOARTHRITIS | ankylosing spondylitis (AS); decision tree; prediction; radiographic progression; trajectory modeling | C reactive protein; accuracy; adult; age; ankylosing spondylitis; Article; clinical feature; decision tree; disease activity; disease duration; disease exacerbation; erythrocyte sedimentation rate; female; follow up; human; major clinical study; male; medical history; medical record review; non-smoker; prediction; protein blood level; radiography; sex difference; smoking; spinal cord lesion; spine radiography | English | 2022 | 2022-10-20 | 10.3389/fmed.2022.994308 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Serum Zinc and Long-Term Prognosis after Acute Traumatic Brain Injury with Intracranial Injury: A Multicenter Prospective Study | Serum zinc levels in the acute stages after traumatic brain injury (TBI) may be capable of predicting cinical and functional prognoses. This study aimed to evaluate the association between serum zinc levels and long-term survival and neurological outcomes in TBI patients with intracranial injury. This multicenter prospective cohort study enrolled adult TBI patients with intracranial injury who visited emergency departments between December 2018 and June 2020. Serum zinc levels drawn within 24 h after injury were categorized into four groups: low (120.0 mcg/dL). The study outcomes were 6-month mortality and disability (Glasgow Outcome Scale, 1-3). A multilevel multivariable logistic regression analysis was conducted to estimate associations between serum zinc and study outcomes. From the eligible TBI patients (N = 487), the median (interquartile range) serum zinc level was 112.0 mcg/dL (95.0-142.0). Six-month mortality and disability were 21.1% (103/487) and 29.6% (144/487), respectively. Compared to the high-normal zinc group, there were significant associations with 6-month mortality and disability observed in the low zinc group (aORs (95% CIs): 1.91 (1.60-2.28) and 1.95 (1.62-2.36) for the low group; 1.14 (0.67-1.94) and 1.15 (0.91-1.46) for the low-normal group; and 0.72 (0.44-1.16) and 0.88 (0.61-1.27) for the high group, respectively). Among the 122 TBI patients with diabetes mellitus, the low zinc group showed a higher incidence of 6-month mortality (aOR (95% CI): 9.13 (4.01-20.81)) compared to the high-normal zinc group. Moreover, the low and low-normal groups had higher odds for 6-month disability (aORs (95% CIs): 6.63 (3.61-12.15) for the low group and 2.37 (1.38-4.07) for the low-normal group). Serum zinc deficiency is associated with a higher incidence of 6-month mortality and disability after injury for TBI patients with intracranial injury. | Kim, Ki Hong; Ro, Young Sun; Yoon, Hanna; Lee, Stephen Gyung Won; Jung, Eujene; Moon, Sung Bae; Park, Gwan Jin; Do Shin, Sang | Seoul Natl Univ Hosp, Dept Emergency Med, Seoul 03080, South Korea; Seoul Natl Univ Hosp, Biomed Res Inst, Lab Emergency Med Serv, Seoul 03080, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Emergency Med, Seoul 07061, South Korea; Chonnam Natl Univ Hosp, Dept Emergency Med, Gwangju 61469, South Korea; Kyungpook Natl Univ, Sch Med, Dept Emergency Med, Daegu 41404, South Korea; Kyungpook Natl Univ Hosp, Daegu 41404, South Korea; Chungbuk Natl Univ Hosp, Dept Emergency Med, Cheongju 28644, South Korea | Kim, Ki Hong/GXH-0871-2022; Shin, Sang/J-5523-2012 | 57194436697; 37665990400; 57218530108; 57221045307; 57194543281; 57191584601; 57193389046; 57049712400 | ro.youngsun@gmail.com; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 21 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 0.8 | 2025-06-25 | 5 | 5 | traumatic brain injury; prognosis; zinc | TAU PHOSPHORYLATION; ECONOMIC BURDEN; SUPPLEMENTATION; MAGNESIUM; CHELATION; HEALTH | prognosis; traumatic brain injury; zinc | zinc; acute disease; adult; aged; Article; cohort analysis; confidence interval; diabetes mellitus; diabetic patient; disability; emergency ward; female; Glasgow outcome scale; human; human tissue; incidence; long term survival; major clinical study; male; mortality; multicenter study; odds ratio; prognosis; prospective study; traumatic brain injury; zinc blood level; zinc deficiency | English | 2022 | 2022-11 | 10.3390/jcm11216496 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Survival Impact of Residual Cancer Cells in Intraoperative Peritoneal Washes following Radical Hysterectomy for Cervical Cancer | Objective: Residual cancer cells (RCCs) contribute to cancer recurrence either because of tumor spillage or undetectable pre-existing micrometastatic tumor clones. We hypothesized that the pathologic evaluation of intraoperative peritoneal washes may reveal RCCs. The aim of this study was to evaluate the survival impact of RCCs identified in intraoperative peritoneal washes and their correlation with clinicopathologic parameters following radical hysterectomy for cervical cancer. Methods: A total of 229 patients with cervical cancer who underwent radical hysterectomy with pelvic and/or paraaortic lymphadenectomy were included. The intraoperative peritoneal washes after surgery were filtered through a strainer and the presence of tumor cells in the residual aspirate was determined. Univariate and multivariate analyses of clinicopathological parameters were performed to identify predictors of recurrence. Results: RCCs in intraoperative peritoneal washes were identified in 19 patients (8.3%). Multivariate analysis revealed that deep stromal invasion (hazard ratio [HR], 13.32; 95% confidence interval [CI], 1.81-98.27; p = 0.0111), lymph node metastasis (HR, 2.00; 95% CI, 1.01-3.99; p = 0.0482), and neoadjuvant chemotherapy (HR, 2.34; 95% CI, 1.89-4.61; p = 0.0139) were associated with tumor recurrence. However, the presence of RCCs was not associated with tumor recurrence (HR, 2.60; 95% CI, 0.74-9.11; p = 0.1352). Multiple logistic regression analysis revealed that RCCs were associated with neoadjuvant chemotherapy (odds ratio [OR], 0.22; 95% CI, 0.05-0.99; p = 0.0488) and large tumor size (OR, 4.16; 95% CI, 0.77-22.48; p = 0.0981). Conclusions: Although the presence of RCCs in intraoperative peritoneal washes do not significantly impact survival outcomes, there was a tendency of inferior survival outcomes in patients with RCCs. RCCs were associated with neoadjuvant chemotherapy and large tumor size. | Kim, Jong Mi; Chong, Gun Oh; Park, Nora Jee-Young; Choi, Yeong Eun; Lee, Juhun; Lee, Yoon Hee; Hong, Dae Gy; Park, Ji Young | Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu 41944, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Clin Omics Res Ctr, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 41944, South Korea | 57212764251; 23099068000; 57226185359; 57668095700; 57360628800; 37088851700; 26656670100; 57210160197 | jjong9uu@gmail.com;gochong@knu.ac.kr;pathpjy@knu.ac.kr;obgy.ye@gmail.com;gyjhlee@knu.ac.kr;yhlee1017@knu.ac.kr;dghong@knu.ac.kr;jyparkmd@knu.ac.kr; | JOURNAL OF CLINICAL MEDICINE | J CLIN MED | 2077-0383 | 11 | 9 | SCIE | MEDICINE, GENERAL & INTERNAL | 2022 | 3.9 | 34.0 | 0 | 2025-06-25 | 0 | 0 | cervical cancer; residual cancer cells; peritoneal washes; radical hysterectomy; prognosis | NEOADJUVANT CHEMOTHERAPY; STAGE IB1; SURGERY; LAPAROSCOPY; OUTCOMES | cervical cancer; peritoneal washes; prognosis; radical hysterectomy; residual cancer cells | adult; Article; cancer cell; confidence interval; female; hazard ratio; human; human cell; human tissue; intraoperative peritoneal wash; lymph node metastasis; major clinical study; middle aged; multivariate analysis; multivariate logistic regression analysis; neoadjuvant chemotherapy; peroperative care; radical hysterectomy; residual cancer cell; treatment outcome; tumor invasion; tumor recurrence; tumor volume; univariate analysis; uterine cervix cancer | English | 2022 | 2022-05 | 10.3390/jcm11092659 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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