연구성과로 돌아가기
2021 연구성과 (135 / 281)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | ○ | Article | Water Supply Reliability of Agricultural Reservoirs under Varying Climate and Rice Farming Practices | Technological development and climate change dictate farming practices, which can directly affect irrigation water requirement and supply. In this article, the water supply reliability (WSR) of 62 major Korean agricultural reservoirs was comprehensively evaluated for varying climate and farming practices. Field surveys identified the recent divergence from standard rice farming practices and a 45-year daily weather data set (1973-2017) was examined to understand the phenomenon of climate change. Effective rainfall increments mitigated the imminent surges in rice irrigation water requirements driven by warming-led accelerated crop evapotranspiration rates; therefore, climate change marginally influenced the WSR of selected reservoirs. The transplanting period and associated water consumption were the primary deviations from standard rice farming practices. A significantly prolonged transplanting period seriously compromised the WSR of agricultural reservoirs and the maximum number of unsafe reservoirs was detected for a 24-day increase in the transplanting period. A watershed/irrigated area ratio of less than 2.5 was the lower threshold below which all the reservoirs had unsafe WSR regardless of the climate change and/or farming practices. Recent variations in farming practices were the primary cause of reservoir failure in maintaining the WSR. | Cho, Gun-Ho; Ahmad, Mirza Junaid; Choi, Kyung-Sook | Kyungpook Natl Univ, Dept Agr Civil Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Dept Agr Civil Engn, Daegu 41566, South Korea | ; Ahmad, Mirza/AAD-5982-2020 | 57208327000; 57201479907; 54392662900 | wshh1212@naver.com;agri.junaid1205@gmail.com;ks.choi@knu.ac.kr; | WATER | WATER-SUI | 2073-4441 | 13 | 21 | SCIE | ENVIRONMENTAL SCIENCES;WATER RESOURCES | 2021 | 3.53 | 35.5 | 0.63 | 2025-07-30 | 8 | 8 | climate change; rice farming practices; irrigation water requirement; water supply reliability; agricultural reservoirs | IRRIGATION VULNERABILITY ASSESSMENT; FAO PENMAN-MONTEITH; REQUIREMENT; MANAGEMENT; UNCERTAINTY | Agricultural reservoirs; Climate change; Irrigation water requirement; Rice farming practices; Water supply reliability | Korea; Agricultural robots; Climate change; Irrigation; Reliability; Reservoirs (water); Agricultural reservoirs; Farming practices; Field surveys; Irrigation water requirements; Irrigation water supply; Rice farming practice; Supply reliability; Technological development; Water supply reliability; Weather data; climate change; evapotranspiration; farming system; reservoir; rice; water supply; Water supply | English | 2021 | 2021-11 | 10.3390/w13212988 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Impact of the apolipoprotein E? 4 allele on early Parkinson ? s disease progression | Objective: Emerging evidence shows that apolipoprotein E (APOE) ?4 exacerbates alpha-synuclein pathology. We aimed to investigate whether the APOE ?4 allele contributes to early Parkinson?s disease (PD) progression. Methods: This cohort study included 361 early PD patients who were classified as APOE ?4 carriers (n = 90) and noncarriers (n = 271). The patients underwent yearly motor and nonmotor assessments covering neuropsychiatric, sleep-related, and autonomic symptoms over 5 years of follow-up. Dopamine transporter (DAT) imaging was conducted at baseline and the 1-, 2-, and 4-year follow-up visits. Results: The APOE ?4 carriers had steeper declines in the Montreal Cognitive Assessment score (p=0.005) and the semantic fluency test score (p=0.012) than the noncarriers. No significant between-group differences in the longitudinal changes in motor, other nonmotor, and DAT imaging variables were observed. Conclusions: Our exploratory analyses show that only cognitive performance was negatively affected by the APOE ?4 allele in the progression of early PD. More specifically, this allele was associated with poorer performance in semantic verbal fluency among cognitive domains. | Kim, Ryul; Park, Sangmin; Yoo, Dallah; Jun, Jin-Sun; Jeon, Beomseok | Inha Univ Hosp, Dept Neurol, Incheon, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Kyungpook Natl Univ, Dept Neurol,Sch Med, Daegu, South Korea; Kyung Hee Univ, Med Ctr, Dept Neurol, Seoul, South Korea; Hallym Univ, Coll Med, Kangnam Sacred Heart Hosp, Dept Neurol, Seoul, South Korea; Seoul Natl Univ Hosp, Coll Med, Dept Neurol, Seoul, South Korea | Yoo, Dallah/ABB-6365-2021 | 56591470700; 57197524938; 57202011449; 56523978900; 7102161956 | junjs@hallym.or.kr; | PARKINSONISM & RELATED DISORDERS | PARKINSONISM RELAT D | 1353-8020 | 1873-5126 | 83 | SCIE | CLINICAL NEUROLOGY | 2021 | 4.402 | 35.6 | 0.74 | 2025-07-30 | 11 | 10 | Apolipoprotein; Motor; Nonmotor; Dopamine transporter | ALPHA-SYNUCLEIN; AMYLOID-BETA; TAU | Apolipoprotein; Dopamine transporter; Motor; Nonmotor; Parkinson's disease | Aged; Alleles; Apolipoprotein E4; Cognitive Dysfunction; Disease Progression; Dopamine Plasma Membrane Transport Proteins; Female; Follow-Up Studies; Humans; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; apolipoprotein E4; dopamine transporter; levodopa; apolipoprotein E4; dopamine transporter; adult; apolipoprotein epsilon 4 gene; Article; balance impairment; cognition; cohort analysis; controlled study; disease exacerbation; female; follow up; gait disorder; human; language; major clinical study; male; mental deterioration; Montreal cognitive assessment; Parkinson disease; priority journal; semantic verbal fluency; single photon emission computed tomography; tremor; Unified Parkinson Disease Rating Scale; aged; allele; cognitive defect; complication; diagnostic imaging; disease exacerbation; genetics; middle aged; Parkinson disease; pathophysiology; positron emission tomography | English | 2021 | 2021-02 | 10.1016/j.parkreldis.2021.01.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Lighthouse in the open sea of spastic ataxia; what are the features that should not be missed in SPG11? | Park, Sangmin; Kim, Ah Reum; Kim, Nayoung K. D.; Park, Woong-Yang; Kim, Ji Sun; Oh, Eungseok | Kyungpook Natl Univ, Dept Neurol, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Neurosurg Ctr, Daegu, South Korea; Seoul Natl Univ Hosp, Biomed Res Inst, Prote Core Facil, Seoul, South Korea; Samsung Med Ctr, Samsung Genome Inst, Seoul, South Korea; Sungkyunkwan Univ, Dept Mol Cell Biol, Sch Med, Suwon, Gyeonggi Do, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, Seoul, South Korea; Chungnam Natl Univ, Sch Med, Dept Neurol, Chungnam Natl Univ Hosp, Daejeon, South Korea | ; Oh, Eungseok/AAL-8935-2020 | massive@cnuh.co.kr; | PARKINSONISM & RELATED DISORDERS | PARKINSONISM RELAT D | 1353-8020 | 1873-5126 | 91 | SCIE | CLINICAL NEUROLOGY | 2021 | 4.402 | 35.6 | 2 | Spastic paraplegia 11; Metachromatic leukodystrophy; Thin corpus callosum; "Ears of the lynx" sign | METACHROMATIC LEUKODYSTROPHY | English | 2021 | 2021-10 | 10.1016/j.parkreldis.2021.04.021 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Correction | Multi-Modal Integration of EEG-fNIRS for Brain-Computer Interfaces - Current Limitations and Future Directions (vol 11, 503, 2017) | Ahn, Sangtae; Jun, Sung C. | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu, South Korea; Gwangju Inst Sci & Technol, Sch Elect Engn & Comp Sci, Gwangju, South Korea | JUN, SUNG/AAJ-2677-2020; Ahn, Sangtae/AFQ-7342-2022 | 55468016100; 57195404000 | scjun@gist.ac.kr; | FRONTIERS IN HUMAN NEUROSCIENCE | FRONT HUM NEUROSCI | 1662-5161 | 15 | SCIE | NEUROSCIENCES;PSYCHOLOGY | 2021 | 3.473 | 35.6 | 3.5 | 2025-07-30 | 1 | 2 | multi-modal integration; electroencephalography (EEG); functional near-infrared spectroscopy (fNIRS); brain-computer interface (BCI) | brain-computer interface (BCI); electroencephalography (EEG); functional near-infrared spectroscopy (fNIRS); multi-modal integration | erratum | English | 2021 | 2021-02-01 | 10.3389/fnhum.2021.645869 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Nocturnal stridor in multiple system atrophy: Video-polysomnography and clinical features | Introduction: Nocturnal stridor, a life-threatening condition linked to respiratory failure and sudden death during sleep, is a serious issue in patients with multiple system atrophy (MSA). However, little is known about polysomnographic findings and clinical features of MSA patients with nocturnal stridor. Hence, we investigated video-polysomnography (VPSG) findings and clinical features associated with nocturnal stridor in patients with MSA. Methods: We retrospectively analyzed the clinical data of patients with MSA (n = 49) who underwent overnight VPSG for the evaluation of sleep-disordered breathing. The presence of nocturnal stridor was confirmed based on overnight VPSG findings. Clinical data, including VPSG findings and clinical features, were compared between MSA patients with and without nocturnal stridor. Results: Nocturnal stridor was present in 31 (63.3%) patients with MSA. Patients with stridor showed significantly higher apnea-hypopnea, respiratory disturbance, and oxygen desaturation indices than those without stridor (P = 0.024, P = 0.049, and P = 0.006, respectively). Patients with stridor had more severe axial motor features, more impaired activities of daily living, and longer disease duration than those without stridor (P = 0.012, P = 0.036, and P = 0.003, respectively). However, there were no significant between-group differences in sex, age at disease onset, MSA subtype, parkinsonian features, cerebellar ataxia, residual urine volume, or systolic and diastolic blood pressure change. Conclusions: MSA with nocturnal stridor is related to higher apnea indices in conjunction with higher O2 desaturation index, more severe axial motor features, more impaired activities of daily living, and longer disease duration. | Ryu, Ho-Sung; Kim, Hyo Jae; You, Sooyeoun; Kim, Mi-Jung; Kim, Young Jin; Kim, Juyeon; Kim, Kiju; Lee, Sang-Ahm; Chung, Sun Ju | Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Dept Neurol, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurol, Daegu, South Korea; Bobath Mem Hosp, Dept Neurol, Seongnam, South Korea; Best Heals Hosp, Dept Neurol, Ansan, South Korea; Metro Hosp, Dept Neurol, Anyang, South Korea; Good Light Hosp, Dept Neurol, Gwangju, South Korea | ; Lee, Dong/J-2778-2012 | 57014206500; 57193096910; 55355547900; 57985117300; 57207443135; 57203325111; 56505680500; 57190211641; 56882955600 | sjchung@amc.seoul.kr; | PARKINSONISM & RELATED DISORDERS | PARKINSONISM RELAT D | 1353-8020 | 1873-5126 | 89 | SCIE | CLINICAL NEUROLOGY | 2021 | 4.402 | 35.6 | 0.28 | 2025-07-30 | 4 | 4 | Multiple system atrophy; Video-polysomnography; Nocturnal stridor; Axial motor features | VOCAL CORD MOTION; CONSENSUS STATEMENT; LARYNGEAL STRIDOR; SLEEP; DISORDERS; DIAGNOSIS; DEATH | Axial motor features; Multiple system atrophy; Nocturnal stridor; Video-polysomnography | Activities of Daily Living; Aged; Female; Humans; Male; Middle Aged; Multiple System Atrophy; Polysomnography; Respiratory Sounds; Retrospective Studies; Sleep Apnea Syndromes; Time Factors; Video Recording; adult; aged; aging; apnea hypopnea index; Article; axial motor disease; cerebellar ataxia; clinical article; clinical feature; clinical study; comparative study; controlled study; daily life activity; diastolic blood pressure; disease duration; disease severity; female; human; male; motor dysfunction; nocturnal stridor; oxygen desaturation; parkinsonism; polysomnography; respiratory failure; retrospective study; sex ratio; Shy Drager syndrome; sleep disordered breathing; stridor; systolic blood pressure; urine volume; video polysomnography; abnormal respiratory sound; complication; middle aged; pathophysiology; sleep disordered breathing; time factor; videorecording | English | 2021 | 2021-08 | 10.1016/j.parkreldis.2021.03.015 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Real-world experience of afatinib as first-line therapy for advanced EGFR mutation-positive non-small cell lung cancer in Korea | Background: We investigated the clinical characteristics and treatment outcomes of Korean patients receiving first-line afatinib for advanced epidermal growth factor receptor mutation-positive (EGFRm(+)) non-small cell lung cancer (NSCLC) in a real-world setting. Methods: Electronic case reports were retrospectively reviewed from patients across 15 sites in South Korea. Outcome measures included baseline characteristics, overall response rate (ORR), time-to-treatment discontinuation (TTD), and overall survival (OS). Subgroups were: presence/absence of brain metastases at baseline, dose reductions, and baseline EGFR mutation category. Results: Among 422 patients, 39.8% had brain metastases and 59.0%/25.1%/10.0%/5.0% had Del19/L858R/compound/uncommon EGFR mutations at baseline. ORR was 62.6% overall; responses were observed across all EGFR mutation categories, including against compound mutations. Median TTD was 17.8 months; median OS was not reached (NR). Median TTD and OS were longer in patients without versus with brain metastases (TTD: 22.9 vs. 14.8 months, P=0.001; OS: NR vs. 40.3 months, P=0.0009) and patients with versus without dose reductions (TTD: 22.2 vs. 14.2 months, P=0.0004; OS: NR vs. 40.3 months, P=0.0117). Median OS was 30.5/37.7 months in patients receiving chemotherapy/osimertinib as subsequent therapy. The most common treatment-related adverse events (TRAEs; any grade/grade >= 3) were diarrhea (31.3%/8.5%) and rash (23.0%/8.1%). Overall, 34 patients (8.1%) discontinued afatinib due to A Es. Conclusions: Afatinib was well tolerated with no new safety signals, and efficacy was encouraging in Korean patients with EGFRm(+) NSCLC, including those with baseline brain metastases and/or uncommon EGFR mutations. AE management with dose reductions facilitated a long TTD, prolonging the chemotherapy-free period for many patients. | Lee, Sung Yong; Choi, Chang-Min; Chang, Yoon Soo; Lee, Kye Young; Kim, Seung Joon; Yang, Sei Hoon; Ryu, Jeong Seon; Lee, Jeong Eun; Lee, Shin Yup; Park, Ji Young; Kim, Young-Chul; Oh, In-Jae; Jung, Chi Young; Lee, Sang Hoon; Yoon, Seong Hoon; Choi, Juwhan; Jang, Tae Won | Korea Univ, Guro Hosp, Seoul, South Korea; Ulsan Univ, Asan Med Ctr, Seoul, South Korea; Yonsei Univ, Gangnam Severance Hosp, Seoul, South Korea; Konkuk Univ, Med Ctr, Seoul, South Korea; Catholic Univ, Seoul St Marys Hosp, Seoul, South Korea; Wonkwang Univ Hosp, Iksan, South Korea; Inha Univ Hosp, Incheon, South Korea; Chungnam Natl Univ, Daejeon, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Hallym Univ, Sacred Heart Hosp, Anyang, South Korea; Chonnam Natl Univ, Med Sch, Hwasun, South Korea; Chonnam Natl Univ, Hwasun Hosp, Hwasun, South Korea; Daegu Catholic Univ, Med Ctr, Daegu, South Korea; Yonsei Univ, Severance Hosp, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Yangsan, South Korea; Kosin Univ, Gospel Hosp, Busan, South Korea | ; Lee, Sang-Hoon/ABH-6210-2020; Kim, Yong-Joo/AAK-1840-2021; Park, Jin-Young/HDN-0483-2022; Kim, Jung Oh/JDC-5061-2023; Oh, In-Jae/AAG-5919-2020; Lee, Joo Yong/ADE-2110-2022; Lee, Jeong Eun/R-8689-2019 | 56734650000; 14024046800; 58293916800; 8720534800; 57225930594; 7406950928; 7401868634; 57209104622; 49863712700; 57193095178; 35201246200; 58754601500; 57223991305; 56813014800; 55479240500; 57193228530; 55621853300 | jangtw226@hanmail.net;jangtw22@hanmail.net; | TRANSLATIONAL LUNG CANCER RESEARCH | TRANSL LUNG CANCER R | 2218-6751 | 2226-4477 | 10 | 12 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2021 | 4.726 | 35.6 | 0.76 | 2025-07-30 | 14 | 14 | Afatinib; epidermal growth factor receptor (EGFR); first-line; non-small cell lung cancer (NSCLC); real-world | GROWTH-FACTOR RECEPTOR; SURVIVAL-DATA; OPEN-LABEL; ADENOCARCINOMA; GEFITINIB; OSIMERTINIB; ERLOTINIB; NSCLC; CHEMOTHERAPY; EXON-19 | Afatinib; Epidermal growth factor receptor (EGFR); First-line; Non-small cell lung cancer (NSCLC); Real-world | afatinib; alanine aminotransferase; aspartate aminotransferase; epidermal growth factor receptor; gefitinib; osimertinib; acute kidney failure; adult; Article; brain metastasis; cancer chemotherapy; cohort analysis; diarrhea; drug dose reduction; drug substitution; drug withdrawal; female; human; hyperkalemia; Korea; major clinical study; male; middle aged; non small cell lung cancer; outcome assessment; overall response rate; overall survival; pneumonia; rash; respiratory failure; retrospective study; treatment outcome | English | 2021 | 2021-12 | 10.21037/tlcr-21-501 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Singular value decomposition of the attenuated conical Radon transform with a fixed central axis and opening angle | Several types of conical Radon transforms have been studied since the introduction of the Compton camera. Several factors of a cone of integration can be considered as variables, for example, a vertex, a central axis, and an opening angle. In this paper, we study the conical Radon transform with a fixed central axis and opening angle. Furthermore, we consider the attenuation effect in the conical Radon transform because it allows us to obtain a high-quality reconstruction image. We construct a nonseparable Hilbert space and its maximal orthonormal set. This maximal orthonormal set comprises the eigenfunctions of the attenuated conical Radon transform, i.e. singular value decomposition (SVD). Finally, the inversion formula of the attenuated conical Radon transform is deduced from the SVD. | Jeon, Gihyeon; Moon, Sunghwan. | Kyungpook Natl Univ, Sch Math, Daegu, South Korea; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea | 57220752866; 56063426100 | sunghwan.moon@knu.ac.kr; | INTEGRAL TRANSFORMS AND SPECIAL FUNCTIONS | INTEGR TRANSF SPEC F | 1065-2469 | 1476-8291 | 32 | 10 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2021 | 1.167 | 35.6 | 0.45 | 2025-07-30 | 5 | 5 | Conical Radon transform; orthonormal functions; inversion; singular value decomposition | COMPTON CAMERA; INVERSION; FORMULA | Conical Radon transform; inversion; orthonormal functions; singular value decomposition | English | 2021 | 2021-10-03 | 10.1080/10652469.2020.1846035 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Porphyrin-Based Tumor-Targeting Theranostic Agent: Gd-TDAP | The aim of this work was to evaluate a tumor-targeting porphyrin-based gadolinium complex (Gd-TDAP) for use as an MR/optical imaging agent and potential therapeutic agent. Gd-TDAP had higher longitudinal relaxivity (11.8 mM(-1) s(-1)) than a commercial MRI contrast agent (Omniscan; 3.7 mM(-1) s(-1)) in HSA solution (0.67 mM) at 3 T. The tumor-targeting characteristics were confirmed by T1-weighted MR imaging and optical imaging using an orthotopic brain tumor mouse model, which showed 1.3-fold higher uptake in tumor compared to normal brain tissues. The cell fraction data using U87MG glioblastoma cells indicated the potential for gadolinium neutron capture therapy (Gd-NCT), which requires gadolinium to be inside the cell nucleus. In addition, porphyrin derivatives can be used for photodynamic therapy (PDT), and the results demonstrated that Gd-TDAP has great potential not only as a bimodal imaging agent but also for treatment. | Kim, Soyeon; Yang, Ji-ung; Ahn, Jae Hun; Ko, In Ok; Kim, Jung Young; Lee, Yong Jin; Park, Ji-Ae | Korea Inst Radiol & Med Sci KIRAMS, Div Appl RI, Seoul 01812, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu 41566, South Korea; Seoul Natl Univ, Coll Med, Grad Sch Translat Med, Seoul 03080, South Korea | ; Kim, Kyunghoon/AGO-0079-2022 | 57203773250; 57212217968; 57191577991; 55750434300; 7601371677; 56498070500; 16319690600 | jpark@kirams.re.kr; | ACS MEDICINAL CHEMISTRY LETTERS | ACS MED CHEM LETT | 1948-5875 | 12 | 9 | SCIE | CHEMISTRY, MEDICINAL | 2021 | 4.632 | 35.7 | 0.98 | 2025-07-30 | 11 | 12 | Porphyrin; MRI contrast agent; Fluorescence imaging; PDT; Gd-NCT | IN-VITRO; GADOLINIUM; THERAPY; MRI; BINDING; PROBE | Fluorescence imaging; Gd-NCT; MRI contrast agent; PDT; Porphyrin | 5,10,15,20 (tetra n,n dimethyl 4 aminophenyl)porphyrin; gadodiamide; gadolinium; gadoterate meglumine; human serum albumin; nuclear magnetic resonance imaging agent; porphyrin derivative; unclassified drug; animal experiment; animal tissue; Article; association constant; blood brain barrier; brain tissue; brain tumor; cancer diagnosis; cell fractionation; comparative study; contrast enhancement; controlled study; diagnostic accuracy; DNA helix; fluorescence imaging; gadolinium neutron capture therapy; inductively coupled plasma mass spectrometry; lipophilicity; mouse; mouse model; nonhuman; nuclear magnetic resonance imaging; pharmacokinetic parameters; photodynamic therapy; theranostic nanomedicine; urinary excretion | English | 2021 | 2021-09-09 | 10.1021/acsmedchemlett.1c00283 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The FeⁱV-O• oxyl unit as a key intermediate in water oxidation on the Feⁱⁱⁱ-hydroxide: DFT predictions | The O-O coupling process in water oxidation on the gamma FeOOH hydroxide catalyst is simulated by means of density functional theory using model iron cubane cluster Fe4O4(OH)(4). A key reactive intermediate is proposed to be the HO-Fe-IV-O center dot oxyl unit with terminal oxo radical. The "initial" vertex Fe-III(OH) moiety forms this intermediate at the calculated overpotential of 0.93 V by adding one water molecule and withdrawing two proton-electron pairs. The O-O coupling goes via water nucleophilic attack on the oxyl oxygen to form the O-O bond with a remarkably low barrier of 11 kcal/mol. This process is far more effective than alternative scenario based on direct interaction of two ferryl Fe-IV(sic)O sites (with estimated barrier of 36 kcal/mol) and is comparable with the coupling between terminal oxo center and three-coordinated lattice oxo center (12 kcal/mol barrier). The process of hydroxylation of terminal oxygen inhibits the O-O coupling. Nevertheless, being more effective for ferryl oxygen, the hydroxylation in fact enhances selectivity of the O-O coupling initiated by the oxyl oxygen. | Shubin, Aleksandr A.; Kovalskii, Viktor Yu.; Ruzankin, Sergey Ph.; Zilberberg, Igor L.; Parmon, Valentin N.; Tomilin, Felix N.; Avramov, Pavel V. | Boreskov Inst Catalysis, Novosibirsk 630090, Russia; Novosibirsk State Univ, Novosibirsk, Russia; RAS, FRC Krasnoyarsk Sci Ctr, SB, Kirensky Inst Phys, Krasnoyarsk, Russia; Natl Res Tomsk State Univ, Tomsk, Russia; Kyungpook Natl Univ, Dept Chem, Daegu, South Korea | Tomilin, Felix/F-3763-2014; Kovalskii, Viktor/D-1534-2014; Parmon, Valentin/E-8639-2012; Zilberberg, Igor/AHD-2763-2022; Shubin, Aleksandr/E-9275-2012 | 35498305000; 57189325813; 6602120188; 6602456763; 35495839100; 6602246772; 7004322420 | i.l.zilberberg@catalysis.ru;paul.avramov@gmail.com; | INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY | INT J QUANTUM CHEM | 0020-7608 | 1097-461X | 121 | 10 | SCIE | CHEMISTRY, PHYSICAL;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL;QUANTUM SCIENCE & TECHNOLOGY | 2021 | 2.437 | 35.7 | 0.09 | 2025-07-30 | 1 | 1 | negative spin density; oxyl oxygen; the FeOOH hydroxide; the O O coupling; water oxidation | MECHANISM; ELECTROLYSIS | negative spin density; oxyl oxygen; the FeOOH hydroxide; the O-O coupling; water oxidation | Density functional theory; Hydroxylation; Molecules; Oxygen; Reaction intermediates; Coupling process; Cubane clusters; Direct interactions; Nucleophilic attack; Reactive intermediate; Scenario-based; Water molecule; Water oxidation; Iron compounds | English | 2021 | 2021-05-15 | 10.1002/qua.26610 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | 2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells | Primary cilia mediate the interactions between cells and external stresses. Thus, dysregulation of primary cilia is implicated in various ciliopathies, e.g., degeneration of the retina caused by dysregulation of the photoreceptor primary cilium. Particulate matter (PM) can cause epithelium injury and endothelial dysfunction by increasing oxidative stress and inflammatory responses. Previously, we showed that PM disrupts the formation of primary cilia in retinal pigment epithelium (RPE) cells. In the present study, we identified 2-isopropylmalic acid (2-IPMA) as a novel inducer of primary ciliogenesis from a metabolite library screening. Both ciliated cells and primary cilium length were increased in 2-IPMA-treated RPE cells. Notably, 2-IPMA strongly promoted primary ciliogenesis and restored PM2.5-induced dysgenesis of primary cilia in RPE cells. Both excessive reactive oxygen species (ROS) generation and activation of a stress kinase, JNK, by PM2.5 were reduced by 2-IPMA. Moreover, 2-IPMA inhibited proinflammatory cytokine production, i.e., IL-6 and TNF-alpha, induced by PM2.5 in RPE cells. Taken together, our data suggest that 2-IPMA ameliorates PM2.5-induced inflammation by promoting primary ciliogenesis in RPE cells. | Choi, Ji Yeon; Bae, Ji-Eun; Kim, Joon Bum; Jo, Doo Sin; Park, Na Yeon; Kim, Yong Hwan; Lee, Ha Jung; Kim, Seong Hyun; Kim, So Hyun; Jeon, Hong Bae; Na, Hye-Won; Choi, Hyungjung; Ryu, Hong-Yeoul; Ryoo, Zae Young; Lee, Hyun-Shik; Cho, Dong-Hyung | Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu 41566, South Korea; ENCell Co Ltd, Stem Cell Inst, Seoul 06072, South Korea; R&D Ctr AMOREPACIFIC Corp, Yongin 17074, Gyeonggi Do, South Korea | Na, Hyewon/IVV-4674-2023; Kim, Joon/ADP-8066-2022; Choi, Hye Rin/JDV-9065-2023; RYOO, ZAEYOUNG/AAQ-1573-2020 | 57219085234; 57190605352; 57190611030; 56335489800; 57190609826; 57204676401; 57221856423; 57253406700; 57253406800; 59452113500; 57193759173; 57252786900; 55889917800; 16937104900; 16316010200; 35093684400 | muse41191@naver.com;loveg730@naver.com;kss3213@naver.com;doosinjo@gmail.com;yeonie5613@gmail.com;yoo035913@gmail.com;hajeong1998@naver.com;kgj010@naver.com;ks90608@naver.com;jhb@encellinc.com;serina@amorepacific.com;heart@amorepacific.com;rhr4757@knu.ac.kr;jaewoong64@knu.ac.kr;leeh@knu.ac.kr;dhcho@knu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 26 | 17 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 0.74 | 2025-07-30 | 9 | 10 | primary cilia; 2-IPMA; particulate matter (PM2; 5); inflammation; RPE cells | OXIDATIVE STRESS; REGULATES CILIOGENESIS; PRIMARY CILIUM; AIR-POLLUTION; EXPOSURE; IDENTIFICATION; DISEASE; PROTEIN; INJURY; ACID | 2-IPMA; Inflammation; Particulate matter (PM2.5); Primary cilia; RPE cells | Cilia; Cytokines; Enzyme Activation; Gene Knockdown Techniques; Humans; Inflammation; Malates; MAP Kinase Kinase 4; Oxidative Stress; Particulate Matter; Reactive Oxygen Species; Retina; Retinal Pigment Epithelium; 2-isopropylmalic acid; cytokine; malic acid derivative; mitogen activated protein kinase kinase 4; reactive oxygen metabolite; cilium; enzyme activation; gene knockdown; human; inflammation; metabolism; oxidative stress; particulate matter; retina; retinal pigment epithelium; ultrastructure | English | 2021 | 2021-09 | 10.3390/molecules26175409 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | 5G NR mmWave Indoor Coverage with Massive Antenna System | In this paper, we introduce a novel mmWave access architecture, called mmWave over cable (mmWoC), for achieving effective indoor coverage, which is characterized by using an analog modulated relay link to transport the outdoor mmWave signals to the indoors. To enable an effective mapping of radio signals on the cable sub-carriers, we introduce non-configurable air-to-cable (NC-A2C) scheduler that is characterized by its low control complexity and hardware requirement. We will discuss the merits of the proposed mmWoC access architecture and the NC-A2C scheduler, which are further validated via extensive simulations. | Naqvi, Syed Hassan Raza; Ho, Pin Han; Peng, Limei | Univ Waterloo, Dept Elect & Comp Engn, Waterloo, ON, Canada; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | 56810511600; 7402211578; 7201574271 | shrnaqvi@uwaterloo.ca;p4ho@uwaterloo.ca;auroraplm@knu.ac.kr; | JOURNAL OF COMMUNICATIONS AND NETWORKS | J COMMUN NETW-S KOR | 1229-2370 | 1976-5541 | 23 | 1 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;TELECOMMUNICATIONS | 2021 | 3.908 | 36.0 | 1.53 | 2025-07-30 | 16 | 26 | mmWave; mmWave indoor coverage; mmWave small cell (SC); mmWave wireless over cable (mmWoC) | mmWave; MmWave indoor coverage; MmWave small cell (SC); MmWave wireless over cable (mmWoC) | Antennas; Cables; Millimeter waves; Scheduling; Antenna system; Control complexity; Extensive simulations; Indoor coverage; mm-Wave; Radio signals; Relay links; Sub-carriers; 5G mobile communication systems | English | 2021 | 2021-02 | 10.23919/jcn.2020.000031 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | An Efficient Ionic Liquid-Mediated Extraction and Enrichment of Isoimperatorin from Ostericum koreanum (Max.) Kitagawa | Ionic liquids (ILs) have attracted significant interest because of their desirable properties. These characteristics have improved their application to overcome the shortcomings of conventional separation techniques for phytochemicals. In this study, several ILs were investigated for their capacity to extract isoimperatorin, a bioactive furanocoumarin, from the roots of Ostericum koreanum. Herein, 1-Butyl-3-methylimidazolium tetrafluoroborate ([Bmim][BF4]) was selected as a promising IL for separating isoimperatorin. A central composite design was applied to optimize the extraction conditions. Under the optimal conditions, the yield of isoimperatorin reached 97.17 +/- 1.84%. Additionally, the recovery of isoimperatorin from the [Bmim][BF4] solution was successfully achieved (87.73 +/- 2.37%) by crystallization using water as an antisolvent. The purity of the isoimperatorin was greatly enhanced, from 0.26 +/- 0.28% in the raw material to 26.94 +/- 1.26% in the product, in a one-step crystallization process. Namely, an enhancement of approximately 103-folds was reached. The developed approach overcomes the shortcomings of conventional separation methods applied for gaining isoimperatorin by significantly reducing the laboriousness of the process and the consumption of volatile organic solvents. Moreover, the simplicity and effectiveness of the method are assumed to be valuable for producing isoimperatorin-enriched products and for promoting its purification. This work also confirms the efficiency of ILs as a promising material for the separation of phytochemicals. | Kiyonga, Alice Nguvoko; Park, Gyu Hwan; Kim, Hyun Su; Suh, Young-Ger; Kim, Tae Kon; Jung, Kiwon | CHA Univ, Coll Pharm, Inst Pharmaceut Sci, Sungnam 13844, South Korea; Kyungpook Natl Univ, Coll Pharm, Pharmaceut Sci Res Inst, Daegu 41566, South Korea; Jungwon Univ, Coll Sci & Engn, Chungbuk 28024, South Korea | 57140789000; 9939639300; 57930941800; 7202260475; 56196885800; 56949675400 | gabriella@chauniv.ac.kr;park014@knu.ac.kr;hs8812@snu.ac.kr;ygsuh@cha.ac.kr;tkkim@jwu.ac.kr;pharmj@cha.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 26 | 21 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 0.25 | 2025-07-30 | 5 | 5 | ionic liquids; isoimperatorin; extraction; crystallization; enrichment; Ostericum koreanum | IN-VITRO; ASSISTED EXTRACTION; ANGELICA-DAHURICA; FURANOCOUMARINS; DISCRIMINATION; ANTIOXIDANT; COMBINATION; SEPARATION; GLYCOSIDES; PRODUCTS | Crystallization; Enrichment; Extraction; Ionic liquids; Isoimperatorin; Ostericum koreanum | Apiaceae; Furocoumarins; Ionic Liquids; Molecular Structure; Plant Roots; furocoumarin derivative; ionic liquid; isoimperatorin; Apiaceae; chemical structure; chemistry; isolation and purification; plant root | English | 2021 | 2021-11 | 10.3390/molecules26216555 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Cudraxanthone D Ameliorates Psoriasis-like Skin Inflammation in an Imiquimod-Induced Mouse Model via Inhibiting the Inflammatory Signaling Pathways | Psoriasis is a chronic inflammatory skin disease accompanied by excessive keratinocyte proliferation. Corticosteroids, vitamin D3 analogs, and calcineurin inhibitors, which are used to treat psoriasis, have diverse adverse effects, whereas natural products are popular due to their high efficiency and relatively low toxicity. The roots of the Cudrania tricuspidata (C. tricuspidata) are known to have diverse pharmacological effects, among which the anti-inflammatory effect is reported as a potential therapeutic agent in skin cells. Nevertheless, its effectiveness against skin diseases, especially psoriasis, is not fully elucidated. Here, we investigated the effect of cudraxanthone D (CD), extracted from the roots the C. tricuspidata Bureau, on psoriasis using an imiquimod (IMQ)-induced mouse model and the tumor necrosis factor (TNF)-alpha/interferon (IFN)-gamma-activated keratinocytes. IMQ was topically applied to the back skin of C57BL/6 mice for seven consecutive days, and the mice were orally administered with CD. This resulted in reduced psoriatic characteristics, such as the skin thickness and Psoriasis Area Severity Index score, and the infiltration of neutrophils in IMQ-induced skin. CD inhibited the serum levels of TNF-alpha, immunoglobulin G2a, and myeloperoxidase, and the expression of Th1/Th17 cells in splenocytes. In TNF-alpha/IFN-gamma-activated keratinocytes, CD reduced the expressions of CCL17, IL-1 beta, IL-6, and IL-8 by inhibiting the phosphorylation of STAT1 and the nuclear translocation of NF-kB. Taken together, these results suggest that CD could be a potential drug candidate for the treatment of psoriasis. | Kim, Namkyung; Lee, Soyoung; Kang, Jinjoo; Choi, Young-Ae; Jang, Yong Hyun; Jeong, Gil-Saeng; Kim, Sang-Hyun | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Pharmacol, Daegu 41944, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup 28116, South Korea; Kyungpook Natl Univ, Sch Med, Dept Dermatol, Daegu 41944, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea | 57216981866; 8537269200; 57216977823; 7404777420; 57016046400; 57204396456; 57210450420 | nortonnklab@gmail.com;sylee@kribb.re.kr;jinjoo1kang@gmail.com;korryy@hanmail.net;yhjang@knu.ac.kr;gsjeong@cnu.ac.kr;shkim72@knu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 26 | 19 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 0.9 | 2025-07-30 | 12 | 14 | Cudrania tricuspidata Bureau; cudraxanthone D; psoriasis; imiquimod; keratinocytes | NF-KAPPA-B; CUDRANIA-TRICUSPIDATA; CELLS; PATHOGENESIS; CYTOKINES | Cudrania tricuspidata bureau; Cudraxanthone D; Imiquimod; Keratinocytes; Psoriasis | Administration, Oral; Animals; Anti-Inflammatory Agents; Cell Line; Disease Models, Animal; Female; Humans; Imiquimod; Interferon-gamma; Keratinocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Moraceae; NF-kappa B; Plant Extracts; Plant Roots; Psoriasis; Treatment Outcome; Tumor Necrosis Factor-alpha; Xanthones; antiinflammatory agent; gamma interferon; imiquimod; immunoglobulin enhancer binding protein; plant extract; tumor necrosis factor; xanthone derivative; animal; Bagg albino mouse; C57BL mouse; cell line; chemistry; cytology; disease model; drug effect; female; human; immunology; keratinocyte; Moraceae; mouse; oral drug administration; plant root; psoriasis; treatment outcome | English | 2021 | 2021-10 | 10.3390/molecules26196086 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Differential Regulation of Human Serotonin Receptor Type 3A by Chanoclavine and Ergonovine | Irritable bowel syndrome (IBS) is a chronic disease that causes abdominal pain and an imbalance of defecation patterns due to gastrointestinal dysfunction. The cause of IBS remains unclear, but intestinal-brain axis problems and neurotransmitters have been suggested as factors. In this study, chanoclavine, which has a ring structure similar to 5-hydroxytryptamine (5-HT), showed an interaction with the 5-HT3A receptor to regulate IBS. Although its derivatives are known to be involved in neurotransmitter receptors, the molecular physiological mechanism of the interaction between chanoclavine and the 5-HT3A receptor is unknown. Electrophysiological experiments were conducted using a two-electrode voltage-clamp analysis to observe the inhibitory effects of chanoclavine on Xenopus oocytes in which the h5-HT3A receptor was expressed. The co-application of chanoclavine and 5-HT resulted in concentration-dependent, reversible, voltage-independent, and competitive inhibition. The 5-HT3A response induced by 5-HT was blocked by chanoclavine with half-maximal inhibitory response concentration (IC50) values of 107.2 mu M. Docking studies suggested that chanoclavine was positioned close F130 and N138 in the 5-HT3A receptor-binding site. The double mutation of F130A and N138A significantly attenuated the interaction of chanoclavine compared to a single mutation or the wild type. These data suggest that F130 and N138 are important sites for ligand binding and activity. Chanoclavine and ergonovine have different effects. Asparagine, the 130th amino acid sequence of the 5-HT3A receptor, and phenylalanine, the 138th, are important in the role of binding chanoclavine, but ergonovine has no interaction with any amino acid sequence of the 5-HT3A receptor. The results of the electrophysiological studies and of in silico simulation showed that chanoclavine has the potential to inhibit the hypergastric stimulation of the gut by inhibiting the stimulation of signal transduction through 5-HT3A receptor stimulation. These findings suggest chanoclavine as a potential antiemetic agent for excessive gut stimulation and offer insight into the mechanisms of 5-HT3A receptor inhibition. | Eom, Sanung; Jung, Woog; Lee, Jaeeun; Yeom, Hye Duck; Lee, Shinhui; Kim, Chaelin; Park, Heui-Dong; Lee, Junho H. | Chonnam Natl Univ, Dept Biotechnol, Gwangju 61186, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; GoPath Labs, Buffalo Grove, IL 60089 USA | ; Lee, Jun/G-5089-2012; Lee, Junseong/T-4139-2017; Lee, Jungho/AAJ-7137-2020 | 57195804232; 57222381083; 57206733593; 57189520740; 57210647753; 57210646601; 7601568590; 57189521666 | yeomself2355@gmail.com;crazycell79@nate.com;jaeeun3023@gmail.com;hyeduck@gmail.com;dltlstn39@gmail.com;chaelinkim0215@gmail.com;hpark@knu.ac.kr;leejunho@chonnam.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 26 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 0.49 | 2025-07-30 | 8 | 8 | ergot alkaloids; serotonin receptor; chanoclavine; irritable bowel syndrome | Chanoclavine; Ergot alkaloids; Irritable bowel syndrome; Serotonin receptor | Dose-Response Relationship, Drug; Ergolines; Ergonovine; Humans; Molecular Conformation; Molecular Docking Simulation; Receptors, Serotonin, 5-HT3; Serotonin; Signal Transduction; chanoclavine; ergoline derivative; ergometrine; HTR3A protein, human; serotonin; serotonin 3 receptor; chemistry; conformation; dose response; drug effect; human; metabolism; molecular docking; signal transduction | English | 2021 | 2021-03 | 10.3390/molecules26051211 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Dermatophagoides farinae Extract-Induced BALB/c Mice | The extracts of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) have various therapeutic effects, including inflammation and allergy. In this study, gomisin M2 (GM2) was isolated from S. chinensis and its beneficial effects were assessed against atopic dermatitis (AD). We evaluated the therapeutic effects of GM2 on 2,4-dinitrochlorobenzene (DNCB) and Dermatophagoides farinae extract (DFE)-induced AD-like skin lesions with BALB/c mice ears and within the tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma-stimulated keratinocytes. The oral administration of GM2 resulted in reduced epidermal and dermal thickness, infiltration of tissue eosinophils, mast cells, and helper T cells in AD-like lesions. GM2 suppressed the expression of IL-1 beta, IL-4, IL-5, IL-6, IL-12a, and TSLP in ear tissue and the expression of IFN-gamma, IL-4, and IL-17A in auricular lymph nodes. GM2 also inhibited STAT1 and NF-kappa B phosphorylation in DNCB/DFE-induced AD-like lesions. The oral administration of GM2 reduced levels of IgE (DFE-specific and total) and IgG2a in the mice sera, as well as protein levels of IL-4, IL-6, and TSLP in ear tissues. In TNF-alpha/IFN-gamma-stimulated keratinocytes, GM2 significantly inhibited IL-1 beta, IL-6, CXCL8, and CCL22 through the suppression of STAT1 phosphorylation and the nuclear translocation of NF-kappa B. Taken together, these results indicate that GM2 is a biologically active compound that exhibits inhibitory effects on skin inflammation and suggests that GM2 might serve as a remedy in inflammatory skin diseases, specifically on AD. | Kang, Jinjoo; Lee, Soyoung; Kim, Namkyung; Dhakal, Hima; Kwon, Taeg-Kyu; Kim, Eun-Nam; Jeong, Gil-Saeng; Kim, Sang-Hyun | Kyungpook Natl Univ, Sch Med, Dept Pharmacol, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol, Immunoregulatory Mat Res Ctr, Jeongeup 28116, South Korea; Keimyung Univ, Sch Med, Dept Immunol, Daegu 42601, South Korea; Keimyung Univ, Coll Pharm, Daegu 42601, South Korea | 57216977823; 8537269200; 57216981866; 57195999763; 7202206057; 57201655294; 57204396456; 57210450420 | jinjoo1kang@gmail.com;sylee@kribb.re.kr;nortonnklab@gmail.com;dhakalhima@gmail.com;kwonth@dsmc.or.kr;enkimpharm@gmail.com;gsjeong@kmu.ac.kr;shkim72@knu.ac.kr; | MOLECULES | MOLECULES | 1420-3049 | 26 | 15 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MULTIDISCIPLINARY | 2021 | 4.927 | 36.0 | 0.57 | 2025-07-30 | 4 | 7 | atopic dermatitis; gomisin M2; Dermatophagoides farinae extract; keratinocytes; 2; 4-dinitrochlorobenzene | SCHISANDRA-CHINENSIS; CONTACT-DERMATITIS; CORTICOSTEROIDS; KERATINOCYTES; CONSTITUENTS; SCHIZANDRIN; CYTOKINES; LIGNANS | 2; 4-dinitrochlorobenzene; Atopic dermatitis; Dermatophagoides farinae extract; Gomisin M2; Keratinocytes | Animals; Anti-Inflammatory Agents; Cyclooctanes; Cytokines; Dermatitis, Atopic; Dermatophagoides farinae; Dermis; Dinitrochlorobenzene; Epidermis; Mice; Mice, Inbred BALB C; NF-kappa B; STAT1 Transcription Factor; 1 chloro 2,4 dinitrobenzene; antiinflammatory agent; cyclooctane derivative; cytokine; immunoglobulin enhancer binding protein; STAT1 protein; Stat1 protein, mouse; animal; atopic dermatitis; Bagg albino mouse; chemistry; Dermatophagoides farinae; dermis; epidermis; immunology; mouse | English | 2021 | 2021-08 | 10.3390/molecules26154409 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: