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| ○ | ○ | Article | The Halotolerant Rhizobacterium-Pseudomonas koreensisMU2 Enhances Inorganic Silicon and Phosphorus Use Efficiency and Augments Salt Stress Tolerance in Soybean (Glycine maxL.) | Optimizing nutrient usage in plants is vital for a sustainable yield under biotic and abiotic stresses. Since silicon and phosphorus are considered key elements for plant growth, this study assessed the efficient supplementation strategy of silicon and phosphorus in soybean plants under salt stress through inoculation using the rhizospheric strain-Pseudomonas koreensisMU2. The screening analysis of MU2 showed its high salt-tolerant potential, which solubilizes both silicate and phosphate. The isolate, MU2 produced gibberellic acid (GA(1), GA(3)) and organic acids (malic acid, citric acid, acetic acid, and tartaric acid) in pure culture under both normal and salt-stressed conditions. The combined application of MU2, silicon, and phosphorus significantly improved silicon and phosphorus uptake, reduced Na(+)ion influx by 70%, and enhanced K(+)uptake by 46% in the shoots of soybean plants grown under salt-stress conditions. MU2 inoculation upregulated the salt-resistant genesGmST1,GmSALT3, andGmAKT2, which significantly reduced the endogenous hormones abscisic acid and jasmonic acid while, it enhanced the salicylic acid content of soybean. In addition, MU2 inoculation strengthened the host's antioxidant system through the reduction of lipid peroxidation and proline while, it enhanced the reduced glutathione content. Moreover, MU2 inoculation promoted root and shoot length, plant biomass, and the chlorophyll content of soybean plants. These findings suggest that MU2 could be a potential biofertilizer catalyst for the amplification of the use efficiency of silicon and phosphorus fertilizers to mitigate salt stress. | Adhikari, Arjun; Khan, Muhammad Aaqil; Lee, Ko-Eun; Kang, Sang-Mo; Dhungana, Sanjeev Kumar; Bhusal, Narayan; Lee, In-Jung | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Rural Dev Adm, Dept Southern Area Crop Sci, Natl Inst Crop Sci, Miryang 50424, South Korea; Seoul Natl Univ, Dept Forest Sci, Seoul 08826, South Korea | ; Dhungana, Sanjeev/O-4097-2017; Adhikari, Arjun/AAV-6297-2021; Kang, Sang-Mo/MBG-7823-2025; Khan, Muhammad/ABB-9797-2021; Dhungana, Sanjeev Kumar/O-4097-2017; Bhusal, Narayan/AAE-9086-2019; Lee, In-Jung/GLS-0432-2022; Adhikari, Arjun/JCO-3306-2023 | 57195601415; 57188585606; 56191302700; 56189696900; 56269940800; 57199327486; 16425830900 | farmerarjun7@gmail.com;aqil_bacha@yahoo.com;ge8340@daum.net;kmoya@hanmail.net;sanjeev@korea.kr;bhusal.narayan4@gmail.com;ijlee@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 8 | 9 | SCIE | MICROBIOLOGY | 2020 | 4.128 | 37.9 | 2.31 | 2025-06-25 | 51 | 54 | silicon; phosphorus; solubilization; P; koreensisMU2; soybean; salinity | PHOSPHATE SOLUBILIZING BACTERIA; GROWTH PROMOTING RHIZOBACTERIA; HOST-PLANT GROWTH; ABIOTIC STRESS; SALINITY TOLERANCE; BIOTIC STRESSES; GIBBERELLINS; ACID; SOIL; INOCULATION | P. koreensis MU2; Phosphorus; Salinity; Silicon; Solubilization; Soybean | English | 2020 | 2020-09 | 10.3390/microorganisms8091256 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Transcriptional Regulation of the Outer Membrane Protein A in Acinetobacter baumannii | Acinetobacter baumannii is known for its virulence in severely ill, hospitalized patients and for exhibiting multidrug resistance. A. baumannii infection treatment poses a serious problem in clinical environments. The outer membrane protein A (OmpA) of the Acinetobacter genus is involved in bacterial virulence. Regulatory factors of OmpA in the post-transcriptional stage have been previously identified. However, the regulatory factors that act before the transcriptional stage remain unclear. We investigated the A1S₀₃₁₆ gene that encodes a putative transcription factor for OmpA expression in A. baumannii. A1S₀₃₁₆ was purified and examined using size-exclusion chromatography, which revealed that it forms an oligomer. The binding affinity of A1S₀₃₁₆ to the OmpA promoter region was also examined. We compared the binding affinity to the OmpA promotor region between A1S₀₃₁₆ and the AbH-NS protein. A1S₀₃₁₆ showed higher binding affinity to the OmpA promotor region than did H-NS. We examined the regulatory effect of these proteins on OmpA expression in A. baumannii using real-time qPCR and various in vitro tools. Our results indicated that A1S₀₃₁₆ acts as an anti-repressor on the promotor region of the OmpA gene by inhibiting the binding of the AbH-NS protein. This study was the first demonstration of the transcriptional regulation of OmpA expression. | Oh, Kyu-Wan; Kim, Kyeongmin; Islam, Md Maidul; Jung, Hye-Won; Lim, Daejin; Lee, Je Chul; Shin, Minsang | Kyungpook Natl Univ, Sch Med, Dept Microbiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Chonnam Natl Univ, Sch Med, Dept Microbiol, Gwangju 61468, South Korea | ; Islam, Md. Maidul/AAX-1696-2021 | 57216828073; 57216604095; 57216605059; 57216604654; 55634007200; 25930392000; 7401536650 | okwan0609@knu.ac.kr;horizon112@naver.com;maidulbau6923@gmail.com;jhw921011@naver.com;kumdoman7@hanmail.net;jclee@knu.ac.kr;shinms@knu.ac.kr; | MICROORGANISMS | MICROORGANISMS | 2076-2607 | 8 | 5 | SCIE | MICROBIOLOGY | 2020 | 4.128 | 37.9 | 0.52 | 2025-06-25 | 13 | 12 | Acinetobacter baumannii; OmpA; A1S_0316; H-NS; transcription regulator | MESSENGER-RNA STABILITY; DEPENDENT REGULATION; PATHOGENESIS; REPRESSION | A1S_0316; Acinetobacter baumannii; H-NS; OmpA; Transcription regulator | English | 2020 | 2020-05 | 10.3390/microorganisms8050706 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Short survey | Ultrasmall europium, gadolinium, and dysprosium oxide nanoparticles: Polyol synthesis, properties, and biomedical imaging applications | Imaging agents are crucial in diagnosing diseases. Ultrasmall lanthanide oxide (Ln2O3) na-noparticles (NPs) (Ln = Eu, Gd, and Dy) are promising materials as high-performance imaging agents because of their excellent magnetic, optical, and X-ray attenuation properties which can be applied as magnetic resonance imaging (MRI), fluorescence imaging (FI), and X-ray computed tomography (CT) agents, respectively. Ultrasmall Ln2O3 NPs (Ln = Eu, Gd, and Dy) are reviewed here. The reviewed topics include polyol synthesis, characterization, properties, and biomedical imaging applications of ultrasmall Ln2O3 NPs. Recently published papers were used as bibliographic databases. A polyol method is a simple and efficient one-pot synthesis for preparing ultrasmall Ln2O3 NPs. Ligand-coated ultrasmall Ln2O3 NPs have good colloidal stability, biocompatibility, and renal excretion ability suitable for in vivo imaging applications. Ultrasmall Eu2O3 NPs display photoluminescence in the red region suitable for use as FI agents. Ultrasmall Gd2O3 NPs have r1 values higher than those of commer-cial molecular contrast agents and r2/r1 ratios close to 1, which make them eligible for use as T1 MRI contrast agents. Ultrasmall Dy2O3 NPs exhibit high r2 and negligible r1 values, which make them suitable for use as T2 MRI contrast agents. All ultrasmall Ln2O3 NPs have high X-ray attenuation powers which make them suitable for use as CT contrast agents. Unmixed, mixed, or doped ultrasmall Ln2O3 NPs with different Ln are extremely useful for in vivo imaging applications in MRI, CT, FI, MRI-CT, MRI-FI, CT-FI, and MRI-CT-FI. © 2020 Bentham Science Publishers. | Yue, Huan; Park, Ja Young; Chang, Yongmin; Lee, Gang Ho | Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea; Department of Molecular Medicine and Medical & Biological Engineering, DNN, School of Medicine, KNU and Hospital, Taegu, 41566, South Korea; Department of Chemistry, Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu, 41566, South Korea | 57200329016; 8970279400; 7501840633; 7404851841 | ychang@knu.ac.kr;ghlee@mail.knu.ac.kr; | Mini-Reviews in Medicinal Chemistry | MINI-REV MED CHEM | 1389-5575 | 1875-5607 | 20 | 17 | SCIE | CHEMISTRY, MEDICINAL | 2020 | 3.862 | 37.9 | 1.02 | 2025-06-25 | 13 | Biomedical imaging; CT; FI; Ln<sub>2</sub>O<sub>3</sub> nanoparticle ((Ln = Eu, Gd, and Dy); MRI; Smart polyol synthesis | Dysprosium; Europium; Gadolinium; Image Processing, Computer-Assisted; Metal Nanoparticles; Polymers; gadolinium chelate; metal nanoparticle; polyol; ultrasmall dysprosium oxide nanoparticle; ultrasmall europium oxide nanoparticle; ultrasmall gadolinium oxide nanoparticle; unclassified drug; dysprosium; dysprosium oxide; europium; gadolinium; metal nanoparticle; polymer; polyol; biocompatibility; blood toxicity; cell viability; coating (procedure); colloid; computer assisted tomography; contrast enhancement; crystal structure; cytotoxicity; drug excretion; drug synthesis; fluorescence imaging; human; hydrodynamics; hydrophilicity; LD50; liver toxicity; multimodal imaging; nephrogenic systemic fibrosis; nephrotoxicity; neurotoxicity; nonhuman; nuclear magnetic resonance imaging; one pot synthesis; particle size; photoluminescence; radiation attenuation; Short Survey; chemistry; image processing | English | Final | 2020 | 10.2174/1389557520666200604163452 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | Fibrosis-4 index as a predictor for mortality in hospitalised patients with COVID-19: a retrospective multicentre cohort study | Objective The reliable risk factors for mortality of COVID-19 has not evaluated in well-characterised cohort. This study aimed to identify risk factors for in-hospital mortality within 56 days in patients with severe infection of COVID-19. Design Retrospective multicentre cohort study. Setting Five tertiary hospitals of Daegu, South Korea. Participants 1005 participants over 19 years old confirmed COVID-19 using real-time PCR from nasopharyngeal and oropharyngeal swabs. Methods The clinical and laboratory features of patients with COVID-19 receiving respiratory support were analysed to ascertain the risk factors for mortality using the Cox proportional hazards regression model. The relationship between overall survival and risk factors was analysed using the Kaplan-Meier method. Outcome In-hospital mortality for any reason within 56 days. Results Of the 1005 patients, 289 (28.8%) received respiratory support, and of these, 70 patients (24.2%) died. In multivariate analysis, high fibrosis-4 index (FIB-4; HR 2.784), low lymphocyte count (HR 0.480), diabetes (HR 1.917) and systemic inflammatory response syndrome (HR 1.714) were found to be independent risk factors for mortality in patients with COVID-19 receiving respiratory support (all p<0.05). Regardless of respiratory support, survival in the high FIB-4 group was significantly lower than in the low FIB-4 group (28.8 days vs 44.0 days, respectively, p<0.001). A number of risk factors were also significantly related to survival in patients with COVID-19 regardless of respiratory support (0-4 risk factors, 50.2 days; 49.7 days; 44.4 days; 32.0 days; 25.0 days, respectively, p<0.001). Conclusion FIB-4 index is a useful predictive marker for mortality in patients with COVID-19 regardless of its severity. | Park, Jung Gil; Kang, Min Kyu; Lee, Yu Rim; Song, Jeong Eun; Kim, Na Young; Kweon, Young Oh; Tak, Won Young; Jang, Se Young; Lee, Changhyeong; Kim, Byung Seok; Hwang, Jae Seok; Jang, Byoung Kuk; Bae, Jinmok; Lee, Ji Yeon; Suh, Jeong Ill; Park, Soo Young; Chung, Woo Jin | Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Dongguk Univ, Gyeongju Hosp, Coll Med, Dept Internal Med, Gyeongju, South Korea | Kim, Seul Kee/A-6076-2015; Kang, Min/U-8050-2018; Park, Jung/AAK-5167-2020; Kim, Nayoung/J-5387-2012; song, jeong/P-9106-2015; Kim, Jin Hyoung/AAE-8050-2019 | 57216816399; 59142854300; 57194094753; 57189097150; 57201292256; 7004694832; 7004074582; 57202881977; 55784781600; 55974276800; 57205851488; 58849853600; 57219922156; 57216774221; 7201515001; 57191674344; 55741230500 | psyoung0419@gmail.com;chung50@dsmc.or.kr; | BMJ OPEN | BMJ OPEN | 2044-6055 | 10 | 11 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.692 | 38.0 | 1.91 | 2025-06-25 | 29 | 27 | Coronavirus; COVID-19; risk factors; fibrosis; mortality; survival | PNEUMONIA; WUHAN | Coronavirus; COVID-19; fibrosis; mortality; risk factors; survival | Age Factors; Aged; Aged, 80 and over; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Betacoronavirus; Cohort Studies; Coronavirus Infections; Diabetes Mellitus; Female; Hospital Mortality; Humans; Immunologic Factors; Lymphopenia; Male; Middle Aged; Pandemics; Platelet Count; Pneumonia, Viral; Proportional Hazards Models; Republic of Korea; Respiration, Artificial; Retrospective Studies; Risk Assessment; Systemic Inflammatory Response Syndrome; alanine aminotransferase; angiotensin receptor antagonist; aspartate aminotransferase; cobicistat plus darunavir; dipeptidyl carboxypeptidase inhibitor; glucocorticoid; hydroxychloroquine; immunoglobulin; lopinavir plus ritonavir; alanine aminotransferase; antivirus agent; aspartate aminotransferase; immunologic factor; adult; age; aged; alanine aminotransferase blood level; antiviral therapy; Article; aspartate aminotransferase blood level; clinical feature; cohort analysis; continuous renal replacement therapy; coronavirus disease 2019; corticosteroid therapy; diabetes mellitus; extracorporeal oxygenation; female; fibrosis 4 index; high flow nasal cannula therapy; hospital mortality; hospital patient; human; immunotherapy; invasive ventilation; lymphocyte count; major clinical study; male; medical record review; mortality risk; multicenter study; nasopharyngeal swab; oropharyngeal swab; overall survival; platelet count; real time polymerase chain reaction; respiratory tract disease assessment; retrospective study; risk factor; South Korea; systemic inflammatory response syndrome; age; artificial ventilation; Betacoronavirus; blood; clinical trial; Coronavirus infection; diabetes mellitus; immunology; lymphocytopenia; middle aged; mortality; pandemic; platelet count; proportional hazards model; risk assessment; very elderly; virus pneumonia | English | 2020 | 2020 | 10.1136/bmjopen-2020-041989 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Guideline-directed medical therapy in elderly patients with heart failure with reduced ejection fraction: a cohort study | Objectives and design Guideline-directed medical therapy (GDMT) with renin-angiotensin system (RAS) inhibitors and beta-blockers has improved survival in patients with heart failure with reduced ejection fraction (HFrEF). As clinical trials usually do not include very old patients, it is unknown whether the results from clinical trials are applicable to elderly patients with HF. This study was performed to investigate the clinical characteristics and treatment strategies for elderly patients with HFrEF in a large prospective cohort. Setting The Korean Acute Heart Failure (KorAHF) registry consecutively enrolled 5625 patients hospitalised for acute HF from 10 tertiary university hospitals in Korea. Participants In this study, 2045 patients with HFrEF who were aged 65 years or older were included from the KorAHF registry. Primary outcome measurement All-cause mortality data were obtained from medical records, national insurance data or national death records. Results Both betablockers and RAS inhibitors were used in 892 (43.8%) patients (GDMT group), beta-blockers only in 228 (11.1%) patients, RAS inhibitors only in 642 (31.5%) patients and neither beta-blockers nor RAS inhibitors in 283 (13.6%) patients (no GDMT group). With increasing age, the GDMT rate decreased, which was mainly attributed to the decreased prescription of beta-blockers. In multivariate analysis, GDMT was associated with a 53% reduced risk of all-cause mortality (HR 0.47, 95% CI 0.39 to 0.57) compared with no GDMT. Use of beta-blockers only (HR 0.57, 95% CI 0.45 to 0.73) and RAS inhibitors only (HR 0.58, 95% CI 0.48 to 0.71) was also associated with reduced risk. In a subgroup of very elderly patients (aged >= 80 years), the GDMT group had the lowest mortality. Conclusions GDMT was associated with reduced 3-year all-cause mortality in elderly and very elderly HFrEF patients. | Seo, Won-Woo; Park, Jin Joo; Park, Hyun Ah; Cho, Hyun-Jai; Lee, Hae-Young; Kim, Kye Hun; Yoo, Byung-Su; Kang, Seok-Min; Baek, Sang Hong; Jeon, Eun-Seok; Kim, Jae-Joong; Cho, Myeong-Chan; Chae, Shung Chull; Oh, Byung-Hee; Choi, Dong-Ju | Hallym Univ, Coll Med, Div Cardiol, Dept Internal Med,Kangdong Sacred Heart Hosp, Seoul, South Korea; Seoul Natl Univ, Cardiovasc Ctr, Div Cardiol, Bundang Hosp, Seongnam, South Korea; Inje Univ, Dept Family Med, Seoul Paik Hosp, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Cardiol, Gwangju, South Korea; Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea; Yonsei Univ, Severance Cardiovasc Hosp, Div Cardiol, Coll Med, Seoul, South Korea; Catholic Univ Korea, Div Cardiol, Dept Internal Med, Seoul, South Korea; Sungkyunkwan Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Asan Med Ctr, Dept Cardiol, Seoul, South Korea; Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju, South Korea; Kyungpook Natl Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Mediplex Sejong Hosp, Incheon, South Korea | choi, jo/O-5940-2014; Jeong, Gi/AAB-2830-2021; Choi, Dong-Ju/J-5686-2012; Oh, Byung-Hee/G-9875-2011 | 36165967900; 35799900000; 13405439400; 35285421400; 56151235500; 56150430800; 7102851884; 7405685375; 7201371594; 7004279641; 36065764100; 7401727518; 7101962036; 57216293873; 35274349200 | djchoi@snubh.org; | BMJ OPEN | BMJ OPEN | 2044-6055 | 10 | 2 | SCIE | MEDICINE, GENERAL & INTERNAL | 2020 | 2.692 | 38.0 | 2.15 | 2025-06-25 | 37 | 42 | HOSPITALIZED-PATIENTS; BETA-BLOCKERS; IMPACT; MORTALITY; REGISTRY; DIAGNOSIS; SURVIVAL; OUTCOMES | adult cardiology; cardiac epidemiology; heart failure | Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Ambulatory Care; Cardiovascular Agents; Cohort Studies; Female; Guideline Adherence; Heart Failure; Humans; Male; Prospective Studies; Republic of Korea; beta adrenergic receptor blocking agent; renin inhibitor; beta adrenergic receptor blocking agent; cardiovascular agent; aged; all cause mortality; Article; clinical feature; cohort analysis; female; geriatric patient; heart failure with reduced ejection fraction; hospital patient; human; major clinical study; male; medical record review; multicenter study; multivariate analysis; outcome assessment; prescription; prospective study; risk reduction; treatment planning; university hospital; very elderly; ambulatory care; heart failure; protocol compliance; South Korea | English | 2020 | 2020-02 | 10.1136/bmjopen-2019-030514 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Nationwide population-based cohort study of adverse obstetric outcomes in pregnancies with myoma or following myomectomy: retrospective cohort study | BackgroundOur objective was to evaluate risks of adverse obstetric outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy.MethodsWe analyzed the national health insurance database, which covers almost the entire Korean population, between 2004 and 2015. The risks of adverse pregnancy outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy, compared to those in women without a diagnosed myoma, were analyzed in multivariate logistic regression analysis.ResultsDuring the study period, 38,402 women with diagnosed myoma(s), 9890 women with a history of myomectomy, and 740,675 women without a diagnosed myoma gave birth. Women with a history of diagnosed myoma(s) and women with a history of myomectomy had significantly higher risks of cesarean section (aOR 1.13, 95% CI 1.1-1.16 and aOR 7.46, 95% CI 6.97-7.98, respectively) and placenta previa (aOR 1.41, 95% CI 1.29-1.54 and aOR 1.58, 95% CI 1.35-1.83, respectively), compared to women without a diagnosed myoma. And the risk of uterine rupture was significantly higher in women with previous myomectomy (aOR 12.78, 95% CI 6.5-25.13), compared to women without a diagnosed myoma, which was much increased (aOR 41.35, 95% CI 16.18-105.69) in nulliparous women. The incidence of uterine rupture was the highest at delivery within one year after myomectomy and decreased over time after myomectomy.ConclusionsWomen with a history of myomectomy had significantly higher risks of cesarean section and placenta previa compared to women without a diagnosed myoma. | Lee, Se Jin; Ko, Hyun Sun; Na, Sunghun; Young, Jin; Seong, Won Joon; Kim, Jong Woon; Shin, Jaeeun; Cho, Hae Joong; Choi, Gyu Yeon; Kim, Jinsil; Cho, Geum Joon; Park, In Yang | Kangwon Natl Univ, Sch Med, Dept Obstet & Gynecol, Chunchon, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Obstet & Gynecol, 222 Banpo Daero, Seoul 06591, South Korea; Catholic Univ Daegu, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Chonnam Natl Univ, Dept Obstet & Gynecol, Med Sch, Gwangju, South Korea; Catholic Univ Korea, Coll Med, Bucheon St Marys Hosp, Bucheon, South Korea; Wonkwang Univ, Coll Med, Dept Obstet & Gynecol, Iksan, South Korea; Soonchunhyang Univ, Dept Obstet & Gynecol, Seoul Hosp, Seoul, South Korea; Korea Univ, Coll Med, Guro Hosp, Dept Obstet & Gynecol, 148 Gurodong Ro, Seoul 08308, South Korea | ; Na, Sunghun/AAE-3929-2022 | 57206256821; 37026301100; 55489142900; 57201130049; 26656946000; 57221537209; 52464595800; 25222370300; 59435846600; 57221537491; 12545334500; 9246349900 | geumjoon@korea.ac.kr;ooooobbbbb@catholic.ac.kr; | BMC PREGNANCY AND CHILDBIRTH | BMC PREGNANCY CHILDB | 1471-2393 | 20 | 1 | SCIE | OBSTETRICS & GYNECOLOGY | 2020 | 3.007 | 38.0 | 0.84 | 2025-06-25 | 10 | 15 | Myoma; Myomectomy; Pregnancy outcome; Uterine rupture | UTERINE FIBROIDS; MANAGEMENT; TRIAL; LABOR | Myoma; Myomectomy; Pregnancy outcome; Uterine rupture | Adult; Cesarean Section; Female; Humans; Leiomyoma; Logistic Models; Multivariate Analysis; Placenta Previa; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Republic of Korea; Retrospective Studies; Uterine Myomectomy; Uterine Neoplasms; Uterine Rupture; adult; adverse outcome; Article; birth; cesarean section; cohort analysis; controlled study; disease risk assessment; female; health insurance; high risk pregnancy; human; major clinical study; male; medical history; multiple pregnancy; multivariate logistic regression analysis; myoma; myomectomy; newborn; nullipara; placenta previa; population research; postpartum hemorrhage; preeclampsia; pregnancy outcome; prematurity; retrospective study; South Korean; uterus rupture; adverse event; leiomyoma; multivariate analysis; myomectomy; placenta previa; pregnancy; pregnancy complication; pregnancy outcome; South Korea; statistical model; uterus cancer; uterus rupture | English | 2020 | 2020-11-23 | 10.1186/s12884-020-03406-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synthesising polymeric dispersants to apply to carbon black pigmented mill bases for use in ink-jet inks | Dyes are an important component of drop-on-demand ink-jet inks and are commonly used in desktop printers. While they offer bright, vivid colour, these dyes exhibit poor light and water fastness. To combat this, researchers have started using pigmented ink-jet inks instead of dye-based inks to improve light and water fastness, but the pigments are insoluble in ink vehicles. To use pigments, dispersants must be applied; however, this is a delicate process because the properties of the dispersant substantially affect how the pigmented mill base must be prepared. In this study, polymeric dispersants are synthesised based on the properties and ratios of monomers and the molecular weights of polymers. In total, 14 types of polymeric dispersants are synthesised and examined, with special attention paid to the dispersing properties of particle size reduction and the stability of the pigmented mill base used to prepare drop-on-demand ink-jet inks. This study describes the synthesis of the dispersants in terms of their suitability for commercial application. | Yoon, Chun; Choi, Jae-Hong | Sejong Univ, Dept Chem, Seoul, South Korea; Kyungpook Natl Univ, Dept Text Syst Engn, Daegu 41566, South Korea | 36909992200; 56175157400 | jaehong@knu.ac.kr; | COLORATION TECHNOLOGY | COLOR TECHNOL | 1472-3581 | 1478-4408 | 136 | 1 | SCIE | CHEMISTRY, APPLIED;ENGINEERING, CHEMICAL;MATERIALS SCIENCE, TEXTILES | 2020 | 1.614 | 38.0 | 0.54 | 2025-06-25 | 20 | 18 | Carbon Black; Comminution; Drops; Ink; Particle Size; Polymers; Carbon black; Drops; Ink jet printers; Military vehicles; Particle size; Polymers; Commercial applications; Desktop printers; Dispersing property; Drop-on demand; Dye-based inks; Ink-jet inks; Particle size reduction; Polymeric dispersants; Ink | English | 2020 | 2020-02 | 10.1111/cote.12446 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Visualization of woven bone structure through analysis of biopsy specimens using synchrotron radiation and conventional X-ray microcomputed tomography | This study explores the application of synchrotron radiation and conventional microcomputed tomography (SR-mu CT and C-mu CT, respectively) in evaluating bone-biopsy specimens. Bone-biopsy specimens were obtained using a trephine bur during bone-graft removal for implant placement six months after performing a maxillary sinus bone-graft procedure. Image data of specimens were obtained using SR-mu CT and C-mu CT. SR-mu CT was performed using the 6C biomedical imaging beamline at the Pohang Accelerator Laboratory with a monochromatic X-ray beam of 23 keV, and C-mu CT was performed using a table-top CT scanner (Skyscan 1272). Reconstruction images obtained using the two methods were qualitatively compared with 2D images evaluated under 3D visualization. The SR-mu CT images, especially of the new-bone-graft-woven-bone formation, were less noisy and sharper than the C-mu CT images. To evaluate the new-bone-graft-woven-bone formation, only the SR-mu CT images showed areas of new bone (NB) formation with bone substitute (BS; Bio-Oss) and woven bone (WB) contact, and correctly visualized true 3D structures of bone formation. Hence, mu CT techniques are non-destructive and can provide detailed images of bone biopsy. In particular, SR-mu CT can be used to obtain improved image quality with contrast of NB, BS and WB, demonstrating a level of detail comparable with bone formation. SR-mu CT could be an unbiased 3D alternative for imaging WB formation and for high-throughput analysis. | Seo, Seung Jun; Kim, Yong Gun | Kyungpook Natl Univ, Sch Dent, Dept Periodontol, Daegu 41940, South Korea; Kyungpook Natl Univ, ITRD, Daegu 41940, South Korea | 59056013900; 57212609160 | periokyg@knu.ac.kr; | JOURNAL OF SYNCHROTRON RADIATION | J SYNCHROTRON RADIAT | 0909-0495 | 1600-5775 | 27 | SCIE | INSTRUMENTS & INSTRUMENTATION;OPTICS;PHYSICS, APPLIED | 2020 | 2.616 | 38.3 | 0 | 2025-06-25 | 0 | 0 | synchrotron radiation X-ray mu CT; conventional X-ray mu CT; woven bone; bone biopsy | MAXILLARY SINUS AUGMENTATION; PHASE-CONTRAST MICROTOMOGRAPHY; HISTOMORPHOMETRIC ANALYSIS; MINERAL DENSITY; FLOOR ELEVATION; MICRO-CT; GRAFT; MICROSTRUCTURE | bone biopsy Kyungpook National University Hospital 2017; conventional X-ray μCT; synchrotron radiation X-ray μCT; woven bone | Absorption, Radiation; Biopsy; Bone and Bones; Bone Regeneration; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Maxilla; Refractometry; Synchrotrons; X-Ray Microtomography; Biopsy; Grafting (chemical); Image enhancement; Medical imaging; Synchrotron radiation; Synchrotrons; Three dimensional computer graphics; Visualization; X rays; Biomedical imaging; High-throughput analysis; Kyungpook National University; Microcomputed tomography; Monochromatic X ray beams; Reconstruction image; Synchrotron radiation x-rays; X ray micro-computed tomography; biopsy; bone; bone regeneration; human; image processing; maxilla; micro-computed tomography; pathology; procedures; radiation absorption; refractometry; surgery; synchrotron; three-dimensional imaging; ultrastructure; Computerized tomography | English | 2020 | 2020-01-01 | 10.1107/s1600577519015182 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A Digital Technique to Replicate Edentulous Arches with Functional Borders and Accurate Maxillomandibular Relationship for Digital Complete Denture | Correct functional border impression and jaw registration is a challenge when edentulous arches are directly digitized with an intraoral scanner. This article describes a digital workflow to replicate complete edentulous arches with full functional contour, and position them in the centric relation using an intraoral scanner, existing denture, and three-dimensional image reversal technique. Based on the reconstructed images, the base and dental parts of the new denture can be designed efficiently and predictably. | Mai, Hang-Nga; Lee, Du-Hyeong | Kyungpook Natl Univ, Inst Translat Res Dent, Daegu, South Korea; Kyungpook Natl Univ, Dept Prosthodont, Sch Dent, Inst Translat Res Dent, 2175 Dalgubeoldae Ro, Daegu 41940, South Korea | ; Mai, Hang-Nga/Q-9865-2018 | 56964780900; 35770948000 | deweylee@knu.ac.kr; | JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY | J PROSTHODONT | 1059-941X | 1532-849X | 29 | 4 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 2.752 | 38.6 | 1.94 | 2025-06-25 | 18 | 21 | Complete denture; functional impression; digital scanning; image reversal; interarch relationship; image registration | IMPRESSION; DIGITIZATION; SURFACE | Complete denture; digital scanning; functional impression; image registration; image reversal; interarch relationship | Computer-Aided Design; Dental Impression Technique; Denture Design; Denture, Complete; Humans; Mouth, Edentulous; complete denture; computer aided design; dental impression; denture design; human; mouth disease | English | 2020 | 2020-04 | 10.1111/jopr.13154 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Clinical Factors to Predict the Response to Concurrent Chemoradiotherapy and Survival in Esophageal Cancer Patients | Background/Alms: Several clinical factors have been used to predict the response for concurrent chemoradiotherapy (CCRT); however, these factors are insufficient for prognostic predictions. We investigated clinical factors to assess whether they could be used to predict the response to CCRT and the survival of patients with esophageal cancer. Methods: Patients with esophageal cancer underwent CCRT from January 2005 to December 2015. Response to CCRT was classified as progressive disease (PD), stationary disease (SD), partial remission (PR), or complete remission (CR). Factors to predict the response to CCRT and patient survival were subsequently investigated. Results: A total of 535 esophageal cancer patients underwent CCRT. Four hundred ninety-three patients were followed up, and patient outcomes were investigated. In the adjusted analysis, patients with advanced stage disease (relative risk [RR], 0.28 in stage III and 0.12 in stage IV compared to stage I), poor performance status, circumferential involvement (RR, 0.61), and male sex (RR, 0.31) were less likely to achieve CR. Advanced stage disease (hazard ratio [HR], 1.71 in stage III/IV), poor CCRT response (HR, 2.82 in PR, 4.47 in SD, 4.77 in PD compared to CR), and poor performance status (HR, 1.38 in ECOG 2-4) were found to increase mortality. Conclusions: Advanced stage disease, poor performance status, male sex, and circumferential involvement were independent predictive factors for a poor response to CCRT. Advanced stage, poor performance status, and poor CCRT response were independent factors for decreased survival. | Nam, Su Youn; Jeon, Seong Woo; Lee, Sang Jik; Kwon, Yong Hwan; Lee, Hyun Seok; Kim, Sung Kook | Kyungpook Natl Univ Hosp, Dept Internal Med, 807 Hoguk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea | ; Kwak, Sang Gyu/AAG-4341-2021; Lee, Seung Hwan/ITT-0638-2023; Jeon, Seongwoo/AAU-4618-2020 | 55617028500; 9733636500; 57202339229; 55775556800; 36647886100; 34770060400 | swjeon@knu.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 14 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 4.519 | 38.6 | 0.26 | 2025-06-25 | 9 | 7 | Esophageal neoplasms; Chemoradiotherapy; Treatment response; Survival | SQUAMOUS-CELL CARCINOMA; PRETREATMENT BIOPSIES PREDICTS; PATHOLOGICAL RESPONSE; EXPRESSION ANALYSIS; PHASE-II; CHEMORADIATION; 5-FLUOROURACIL; RADIOTHERAPY; RESISTANCE; CISPLATIN | Chemoradiotherapy; Esophageal neoplasms; Survival; Treatment response | Aged; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Esophageal Neoplasms; Female; Humans; Male; Middle Aged; Neoplasm Staging; Prognosis; Proportional Hazards Models; capecitabine; cisplatin; fluorouracil; antineoplastic agent; advanced cancer; aged; Article; cancer growth; cancer mortality; cancer regression; cancer risk; cancer staging; cause of death; chemoradiotherapy; controlled study; demography; dose response; electronic medical record; esophageal squamous cell carcinoma; female; follow up; hazard ratio; human; major clinical study; male; multiple cycle treatment; population research; prediction; radiation dose; treatment outcome; treatment response; esophagus tumor; middle aged; pathology; prognosis; proportional hazards model | English | 2020 | 2020-07 | 10.5009/gnl19165 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Clinical Practice and Guidelines for Managing Antithrombotics before and after Endoscopy: A National Survey Study | Background/Aims: The proper handling of antithrombotics is critical, and this study aimed to assess guideline adherence in the management of antithrombotics before and after endoscopy. Methods: A survey questionnaire was developed. The respondents' demographic information was included, and the questionnaire was divided into the first section for forceps biopsy, the second for polypectomy, and the third for endoscopic submucosal dissection (ESD) in which aspirin, clopidogrel, combination therapy (aspirin and clopidogrel), warfarin, and direct oral anticoagulants (apixaban) were prescribed to imaginary patients. Results: A total of 415 endoscopists completed this survey (response rate of 6.2%, 415/6,673). The percentage of respondents who chose to proceed with biopsy for patients taking aspirin, those taking clopidogrel, those under combination therapy, those taking warfarin, and those taking apixaban was 89.4%, 74.2%, 61.0%, 38.6%, and 50.4%, respectively. Most respondents answered that they would discontinue aspirin, clopidogrel, and a combination of both drugs for 5 days before polypectomy or ESD (69.4%/76.9%, 83.6%/83.9%, and 53.3%/65.8%, respectively). The answers indicated that warfarin should be discontinued with heparin bridge therapy in high thromboembolic risk patients (polypectomy 70.1%, ESD 73.5%). Regarding apixaban use in polypectomy and ESD, 63.9% and 58.1% of respondents, respectively, chose answers consistent with the guidelines. Conclusions: The gap between the guidelines and clinical practice in the management of antithrombotics before and after endoscopy is considerable and should be addressed via educational strategies. | Jeon, Seong Woo; Hong, Su Jin; Lee, Soo Teik; Kim, Hyungkil; Chun, Hoon Jai | Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Soonchunhyang Univ, Dept Internal Med, Coll Med, Bucheon, South Korea; Chonbuk Natl Univ Hosp, Dept Internal Med, Jeonju, South Korea; Inha Univ Hosp, Dept Internal Med, Incheon, South Korea; Korea Univ, Inst Gastrointestinal Med Instrument Res, Dept Internal Med, Coll Med, 73 Inchon Ro, Seoul 02841, South Korea | ; Jeon, Seongwoo/AAU-4618-2020; Lee, Si/ABH-1408-2020 | 9733636500; 35285527200; 7601418502; 57941472200; 7202215162 | drchunhj@gmail.com; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 14 | 3 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 4.519 | 38.6 | 0.38 | 2025-06-25 | 7 | 7 | Endoscopy; Guideline adherence; Antithrombotic agent | BLEEDING RISK; AGENTS; ANTIPLATELET; ASPIRIN; THERAPY; RECOMMENDATIONS; ANTICOAGULANTS; POLYPECTOMY; MANAGEMENT; WARFARIN | Antithrombotic agent; Endoscopy; Guideline adherence | Adult; Endoscopy, Digestive System; Female; Fibrinolytic Agents; Guideline Adherence; Health Care Surveys; Humans; Male; Middle Aged; Postoperative Complications; Practice Guidelines as Topic; Practice Patterns, Physicians'; Surgeons; acetylsalicylic acid; apixaban; clopidogrel; heparin; warfarin; fibrinolytic agent; anticoagulant therapy; Article; clinical practice; demography; drug withdrawal; endoscopic submucosal dissection; endoscopist; gastrointestinal endoscopy; human; pilot study; polypectomy; postoperative care; practice guideline; preoperative period; prescription; questionnaire; risk factor; thromboembolism; adult; adverse event; clinical practice; digestive tract endoscopy; female; health care survey; male; middle aged; postoperative complication; protocol compliance; surgeon | English | 2020 | 2020-05 | 10.5009/gnl19133 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Comparison of the Accuracy of Image Registration Methods for Merging Optical Scan and Radiographic Data in Edentulous Jaws | Purpose The image registration of optical scans to radiographic images is essential for performing computer-guided implant surgery. This study aimed to evaluate the effect of different image matching conditions on the accuracy of image registration for computer-guided implant surgery in completely edentulous jaws. Materials and Methods The optical scan image of a completely edentulous study model was registered to the respective cone-beam computed tomography data using three different image matching conditions: small point (SP), large point (LP), and entire surface (ES). For the SP and LP groups, gutta-percha markers (1.0 and 3.0 mm in diameter) were attached to a base template, and a radiopaque impression material was relined on the intaglio surface of template in the ES group. Image registration was performed by 20 operators in the images obtained from each group at an interval of 2 weeks (n = 20 in each group), and the registration accuracy was assessed by calculating the aligned position of the edentulous arch image. One-way analysis of variance with Tukey post hoc tests was used to compare the results among the groups (alpha = 0.05). Results The mean registration error was significantly larger in the SP group (0.52 +/- 0.19 mm) than in the LP group (0.29 +/- 0.08 mm) and ES group (0.27 +/- 0.06 mm) (F = 24.689,p< 0.001). No difference was found between the LP and ES groups. The image matching discrepancy was more homogeneously distributed on the arch in the ES group than in the other groups. Conclusion The accuracy of image registration is affected by the size of the congruent area shown in the optical scan and radiographic images. The entire surface-based matching method is more accurate as compared to the small point-based matching method in the image registration for implant planning in full edentulous jaws. | Woo, Hyun-Wook; Mai, Hang-Nga; Lee, Du-Hyeong | Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea; Kyungpook Natl Univ, Inst Translat Res Dent, Daegu, South Korea | Mai, Hang-Nga/Q-9865-2018 | 57201726465; 56964780900; 35770948000 | deweylee@knu.ac.kr; | JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY | J PROSTHODONT | 1059-941X | 1532-849X | 29 | 8 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 2.752 | 38.6 | 0.65 | 2025-06-25 | 10 | 10 | Image registration; edentulous jaw; image matching; radiopaque; accuracy | COMPUTED-TOMOGRAPHY DATA; IMPLANT; STENT | accuracy; edentulous jaw; image matching; Image registration; radiopaque | Cone-Beam Computed Tomography; Dental Implants; Humans; Imaging, Three-Dimensional; Jaw, Edentulous; Mouth, Edentulous; Surgery, Computer-Assisted; computer assisted surgery; cone beam computed tomography; diagnostic imaging; edentulousness; human; mouth disease; three-dimensional imaging; tooth implant | English | 2020 | 2020-10 | 10.1111/jopr.13216 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Displacement of Customized Abutments Designed on a Working Cast and in the Oral Cavity: A Comparative In Vivo Study | Purpose To compare abutment displacement between the virtual, customized abutment that was designed on a cast and the customized abutment prepared in the oral cavity. Materials and Methods Eleven patients were selected for a single posterior implant prosthetic treatment. The impression was obtained using the closed tray impression method with a vinyl polysiloxane material using a custom tray. The standard tessellation language files of the customized abutment that was designed using the computer-aided design system and acquired with an intraoral scanner in the oral cavity were superimposed and analyzed for distance and angle displacement using the three-dimensional inspection analysis program (Geomagic Control X). In the statistical analysis, distance and angle displacement values were analyzed with the Kruskal-Wallis H test (alpha = 0.05), and a post hoc comparison was performed using the Mann-Whitney U-test and Bonferroni correction method. Results The mean distance and angle displacement of the 15 customized abutments were 89.52 +/- 66.86 mu m and 0.83 +/- 1.21 degrees, respectively. There were significant differences in distance displacement (p < 0.001), and angle displacement (p < 0.001) among the 15 customized abutments, and there were no significant differences in angle displacement along the 4 directions (p = 0.735). Conclusions The displacement values of the customized abutments evaluated in the oral cavity differed significantly from patient to patient. | Lee, Hyunho; Son, Keunbada; Lee, Wan-Sun; Lee, Kyu-Bok | Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea; Kyungpook Natl Univ, A3DI, Daegu, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Dent Sci, Daegu, South Korea | SON, Keunbada/AAG-8089-2019; Son, Keunbada/AAG-8089-2019 | 57211784207; 57202916520; 56103762800; 15925571200 | kblee@knu.ac.kr; | JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY | J PROSTHODONT | 1059-941X | 1532-849X | 29 | 1 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2020 | 2.752 | 38.6 | 0.78 | 2025-06-25 | 6 | 6 | intraoral scan; three-dimensional analysis; customized abutment; dental CAD; CAM; displacement | ACCURACY | customized abutment; dental CAD/CAM; displacement; intraoral scan; three-dimensional analysis | Computer-Aided Design; Dental Abutments; Humans; Mouth; computer aided design; dental abutment; human; mouth | English | 2020 | 2020-01 | 10.1111/jopr.13120 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Impact of Hospital Volume and the Experience of Endoscopist on Adverse Events Related to Endoscopic Retrograde Cholangiopancreatography: A Prospective Observational Study | Background/Alms: Few studies have addressed the relationship between the occurrence of adverse events (AEs) in endoscopic retrograde cholangiopancreatography (ERCP) and hospital case volume or endoscopist's experience with inconsistent results. The aim of our study was to investigate the impact of hospital case volume and endoscopist's experience on the AEs associated with ERCP and to analyze patient- and procedure-related risk factors for post-ERCP AEs. Methods: From January 2015 to December 2015, we prospectively enrolled patients with naive papilla who underwent ERCP at six centers. Patient- and procedure-related variables were recorded on data collection sheets at the time of and after ERCP. Results: A total of 1,191 patients (median age, 71 years) were consecutively enrolled. The overall success rate of biliary cannulation was 96.6%. Overall, 244 patients (20.5%) experienced post-ERCP AEs, including pancreatitis (9.0%), bleeding (11.8%), perforation (0.4%), cholangitis (1.2%), and others (0.9%). While post-ERCP pancreatitis (PEP) was more common when the procedure was performed by less experienced endoscopists, bleeding was more common in high-volume centers and by less experienced endoscopists. Multivariate analysis showed that a less experience in ERCP was significantly associated with PEP (odds ratio [OR], 1.630: 95% confidence interval [CI], 1.050 to 2.531: p=0.030) and post-ERCP bleeding (OR, 1.439; 95% CI, 1.003 to 2.062; p=0.048). Conclusions: Our study demonstrated that overall AEs following ERCP were associated with the experience of the endoscopist. To minimize post-ERCP AEs, rigorous training with a sufficient case volume is required, and treatment strategies should be modified according to the endoscopist's expertise. | Lee, Hyun Jik; Cho, Chang Min; Heo, Jun; Jung, Min Kyu; Kim, Tae Nyeun; Kim, Kook Hyun; Kim, Hyunsoo; Cho, Kwang Bum; Kim, Ho Gak; Han, Jimin; Lee, Dong Wook; Lee, Yoon Suk | Keimyung Univ, Dongsan Med Ctr, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Ctr Pancreatobiliary Tumor, Chilgok Hosp, 807 Hokuk Ro, Daegu 41404, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Med Ctr, Daegu, South Korea; Daegu Fatima Hosp, Dept Internal Med, Daegu, South Korea; Daegu Catholic Univ, Dept Internal Med, Med Ctr, Daegu, South Korea; Inje Univ, Dept Internal Med, Coll Med, Busan, South Korea | ; Lee, Hye/D-9081-2016; Han, Jimin/AAC-5497-2022; Kim, Min/ACN-6827-2022; Lee, Yoon Suk/D-1827-2019; Kim, Seok-Hwan/G-9981-2015; LEE, Yoon-Suk/D-1827-2019 | 55787413100; 57158287600; 36448170600; 56783168100; 8449938100; 37094434600; 57210863621; 7403956834; 7410139763; 8694531200; 57202974895; 57219432560 | amcho@knu.ac.kr;cmcho@knu.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 14 | 2 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 4.519 | 38.6 | 2.43 | 2025-06-25 | 58 | 53 | Cholangiopancreatography; endoscopic retrograde; Adverse events; Hospital volume; Endoscopic experience | POST-ERCP PANCREATITIS; RISK-FACTORS; QUALITY ASSESSMENT; THERAPEUTIC ERCP; COMPLICATIONS; SPHINCTEROTOMY; MANAGEMENT; OPERATORS; OUTCOMES; STONES | Adverse events; Cholangiopancreatography; Endoscopic experience; Endoscopic retrograde; Hospital volume | Aged; Cholangiopancreatography, Endoscopic Retrograde; Clinical Competence; Female; Hospitals, High-Volume; Hospitals, Low-Volume; Humans; Male; Middle Aged; Odds Ratio; Postoperative Complications; Prospective Studies; Risk Factors; Surgeons; Treatment Outcome; acetylsalicylic acid; antithrombocytic agent; gabexate mesilate; indometacin; nafamstat mesilate; nonsteroid antiinflammatory agent; ulinastatin; warfarin; acute pancreatitis; adult; adverse outcome; age; aged; Article; bleeding; cardiovascular disease; cerebrovascular disease; cholangitis; chronic liver disease; clinical effectiveness; common bile duct stone; comorbidity; diabetes mellitus; disease association; disease predisposition; disease severity; diverticulosis; endoscopic retrograde cholangiopancreatography; endoscopist; female; gastrectomy Billroth II; gender; hospital volume; human; incidence; liver resection; liver transplantation; lung disease; major clinical study; male; medical history; multicenter study; observational study; pancreatitis; perforation; periampullary diverticulum; professional competence; prospective study; risk factor; work experience; clinical competence; endoscopic retrograde cholangiopancreatography; high volume hospital; low volume hospital; middle aged; odds ratio; postoperative complication; surgeon; treatment outcome | English | 2020 | 2020-03 | 10.5009/gnl18537 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Risk Factors for Postoperative Recurrence in Korean Patients with Crohn's Disease | Background/Aims: A considerable number of patients with Crohn's disease still need intestinal resection surgery. Postoperative recurrence is an important issue in Crohn's disease management, including the selection of high-risk patients. Eastern Asian patients showed several differences from Caucasian patients. Therefore, we investigated the postoperative surgical recurrence outcome and identified risk factors in Korean patients. Methods: Clinical data of 372 patients with Crohn's disease who underwent first intestinal resection between January 2004 and August 2014 at 14 hospitals in Korea were retrospectively reviewed. Results: Over the follow-up period, 50 patients (17.1%) showed surgical recurrence. The cumulative surgical recurrence rate was 6.5% at 1 year and 15.4% at 7 years. Age under 16 (p=0.011; hazard ratio [HR], 5.136; 95% confidence interval [CI], 1576 to 16.731), colonic involvement (p=0.023; HR , 2.011; 95% CI, 1.102 to 3.670), and the presence of perianal disease at surgery (p=0.008; HR, 2.239; 95% CI, 1.236 to 4.059) were independent risk factors associated with surgical recurrence. Postoperative thiopurine treatment (p=0.002; HR, 0.393; 95% CI, 0.218 to 0.710) was a protective factor for surgical recurrence. Conclusions: Among the disease characteristics at surgery, younger age, colonic location, and perianal lesions were independent risk factors for surgical recurrence. Postoperative thiopurine treatment significantly reduced the incidence of surgical recurrence. | Kim, Sung; Cheon, Jae Hee; Park, Jae Jun; Kim, Eun Soo; Jeon, Seong Woo; Jung, Sung-Ae; Park, Dong Il; Lee, Chang Kyun; Im, Jong Pil; Kim, You Sun; Kim, Hyun Soo; Lee, Jun; Eun, Chang Soo; Lee, Jeong Mi; Jang, Byung Ik; Seo, Geom Seog | Yonsei Univ, Inst Gastroenterol, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Ewha Womans Univ, Dept Internal Med, Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Dept Internal Med, Kangbuk Samsung Hosp, Sch Med, Seoul, South Korea; Kyung Hee Univ, Ctr Crohns & Colitis, Dept Gastroenterol, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Liver Res Inst, Coll Med, Seoul, South Korea; Inje Univ, Dept Internal Med, Coll Med, Seoul Paik Hosp, Seoul, South Korea; Chonnam Natl Univ, Dept Internal Med, Div Gastroenterol, Med Sch, Gwangju, South Korea; Chosun Univ, Dept Internal Med, Coll Med, Gwangju, South Korea; Hanyang Univ, Dept Internal Med, Guri Hosp, Guri, South Korea; Wonkwang Univ, Dept Publ Hlth, Grad Sch, Iksan, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Wonkwang Univ, Digest Dis Res Inst, Dept Internal Med, Coll Med, 460 Iksan Daero, Iksan 54538, South Korea | Cheon, Jae Hee/B-4523-2015; Jeon, Seongwoo/AAU-4618-2020; Kwak, Sang Gyu/AAG-4341-2021; Cheon, Jae/B-4523-2015; Kim, Sang/J-5398-2012; Park, Jaejun/MVW-1869-2025; Kim, Kwang/J-5385-2012; Kim, You Sun/B-2881-2015; Lee, Chang/AAI-1012-2020; Lee, Jun/AAC-6941-2022 | 57093628600; 35200350500; 14120150500; 57203086704; 9733636500; 7403676915; 56524839700; 26434331200; 8108755200; 56565885500; 57210863499; 57202953059; 7004074626; 56660124300; 22953491400; 7006501197 | jbi@med.yu.ac.kr;medsgs@wonkwang.ac.kr; | GUT AND LIVER | GUT LIVER | 1976-2283 | 2005-1212 | 14 | 3 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 4.519 | 38.6 | 0.58 | 2025-06-25 | 12 | 14 | Crohn disease; Recurrence; Surgery; Risk factors; Thiopurine | INFLAMMATORY-BOWEL-DISEASE; CLINICAL CHARACTERISTICS; ILEOCOLIC RESECTION; SURGICAL RECURRENCE; NATURAL-HISTORY; MANAGEMENT; WESTERN; OUTCOMES; EASTERN | Crohn disease; Recurrence; Risk factors; Surgery; Thiopurine | Adolescent; Adult; Crohn Disease; Endoscopy, Gastrointestinal; Female; Humans; Incidence; Male; Postoperative Complications; Postoperative Period; Recurrence; Republic of Korea; Risk Factors; Treatment Outcome; Young Adult; adalimumab; azathioprine; corticosteroid; infliximab; mercaptopurine; mesalazine; adolescent; adult; age distribution; anus disease; Article; clinical feature; controlled study; Crohn disease; female; follow up; human; intestine resection; Korean (people); major clinical study; male; medical record review; perianal disease; postoperative care; postoperative period; preoperative treatment; recurrence risk; recurrent disease; retrospective study; risk factor; risk reduction; Crohn disease; gastrointestinal endoscopy; incidence; pathology; postoperative complication; postoperative period; recurrent disease; South Korea; treatment outcome; young adult | English | 2020 | 2020-05 | 10.5009/gnl19085 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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